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EPHA3 Gene

protein-coding   GIFtS: 69
GCID: GC03P089239

EPH Receptor A3

(Previous name: EphA3)
(Previous symbols: ETK, ETK1, TYRO4)
  See EPHA3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
EPH Receptor A31 2     EphA31
ETK11 2 3 5     HEK42
ETK1 2 3     Ephrin Type-A Receptor 32
TYRO41 2 3     Human Embryo Kinase 12
HEK2 3 5     TYRO4 Protein Tyrosine Kinase2
Eph-Like Tyrosine Kinase 12 3     hEK43
Tyrosine-Protein Kinase Receptor ETK12 3     Human Embryo Kinase3
EK42 3     Tyrosine-Protein Kinase TYRO43
EPH-Like Kinase 42 3     EC 2.7.108
EC 2.7.10.13 8     

External Ids:    HGNC: 33871   Entrez Gene: 20422   Ensembl: ENSG000000445247   OMIM: 1796115   UniProtKB: P293203   

Export aliases for EPHA3 gene to outside databases

Previous GC identifers: GC03P089525 GC03P092010 GC03P089036 GC03P089077


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EPHA3 Gene:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related
receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors
in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich
domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity
of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene
encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for EPHA3 Gene:
EPHA3 (EPH receptor A3) is a protein-coding gene. Diseases associated with EPHA3 include pleomorphic rhabdomyosarcoma, and colorectal cancer. GO annotations related to this gene include GPI-linked ephrin receptor activity. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320
Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds
preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell
migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the
atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the
retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons
during neuromuscular circuit development

Gene Wiki entry for EPHA3 (EPH receptor A3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EPHA3 gene promoter:
         AP-1   HTF   ATF-2   IRF-7A   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPHA3 promoter sequence
   Search Chromatin IP Primers for EPHA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p11.2   Ensembl cytogenetic band:  3p11.1   HGNC cytogenetic band: 3p11.2

EPHA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHA3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P089239:  view genomic region     (about GC identifiers)

Start:
89,156,674 bp from pter      End:
89,531,284 bp from pter
Size:
374,611 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320 (See protein sequence)
Recommended Name: Ephrin type-A receptor 3 precursor  
Size: 983 amino acids; 110131 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a
receptor dimer. Oligomerization is probably required to induce biological responses. Forms a ternary
EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the
EFNA5-EPHA3 complex internalization and function. Interacts with NCK1 (via SH2 domain); mediates EFNA5-EPHA3
signaling (By similarity). Interacts (phosphorylated) with PTPN1; dephosphorylates EPHA3 and may regulate its
trafficking and function. Interacts (phosphorylated) with CRK; mediates EFNA5-EPHA3 signaling through RHOA GTPase
activation
Selected PDB 3D structures from and Proteopedia for EPHA3 (see all 21):
2GSF (3D)        2QO2 (3D)        2QO7 (3D)        2QO9 (3D)        2QOB (3D)        2QOC (3D)    
Secondary accessions: Q9H2V3 Q9H2V4
Alternative splicing: 2 isoforms:  P29320-1   P29320-2   

Explore the universe of human proteins at neXtProt for EPHA3: NX_P29320

Explore proteomics data for EPHA3 at MOPED

Post-translational modifications: 

  • Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1.
    Dephosphorylated by PTPN11
  • Glycosylation2 at Asn232, Asn337, Asn391, Asn404, Asn493
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for EPHA3 (P29320) (see all 62)
     MSNQDVI  RDLAARN  QNNWLRT  RWTSPEA 


    See EPHA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005224.2  NP_872585.1  

    ENSEMBL proteins: 
     ENSP00000337451   ENSP00000399926   ENSP00000419190  

    EPHA3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for EPHA3
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    GenScript Custom Purified and Recombinant Proteins Services for EPHA3
    Novus Biologicals EPHA3 Proteins
    Novus Biologicals EPHA3 Lysates
    Browse Sino Biological Recombinant Proteins
    Sino Biological Cell Lysate for EPHA3
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EPHA3

     
    Search eBioscience for Proteins for EPHA3 

     
    antibodies-online proteins for EPHA3 (7 products) 

     
    antibodies-online peptides for EPHA3

    EPHA3 Antibody Products:

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    Abcam antibodies for EPHA3 (P54764, P29320, P54756)
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    antibodies-online antibodies for EPHA3 (81 products) 

    EPHA3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EPHA3
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    Search eBioscience for ELISAs for EPHA3 
    antibodies-online kits for EPHA3 (13 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor A3
    Ephrin receptor family
    Ephrin receptor family

    Selected InterPro protein domains (see all 18):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P29320

    ProtoNet protein and cluster: P29320

    Selected Blocks protein domains (see all 6):
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with EPHA3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHA3_HUMAN, P29320
    Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds
    preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell
    migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the
    atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the
    retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons
    during neuromuscular circuit development
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for EPHA3:
    EPH-related tyrosine kinase receptor binding ephrins A,expressed in projecting neurons and their target
    fields,involved in short-range contact-mediated axonal guidance,expressed by some pre-B and T cell lines,not
    detectable on normal adult human tissues

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0005003ephrin receptor activity ----
    GO:0005004GPI-linked ephrin receptor activity IDA11870224
    GO:0005515protein binding IPI11870224
         
    Find genes that share ontologies with EPHA3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for EPHA3:
     Decreased substrate adherent c 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Epha3):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  liver/biliary system  mortality/aging 
     respiratory system 

    Find genes that share phenotypes with EPHA3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Epha3tm1Abn for EPHA3

       genOway: Develop your customized and physiologically relevant rodent model for EPHA3

    miRNA
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    Block miRNA regulation of human, mouse, rat EPHA3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EPHA3 (see all 80):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-548j hsa-miR-3607-3p hsa-miR-3653 hsa-miR-550a* hsa-miR-208b hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidEPHA3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EPHA3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): EPHA3 (NM_005233)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA3
    Addgene plasmids for EPHA3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EPHA3_HUMAN, P29320: Isoform 1: Cell membrane; Single-pass type I membrane protein
    EPHA3_HUMAN, P29320: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    extracellular5
    plasma membrane5
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005769early endosome IDA--
    GO:0005887integral component of plasma membrane IDA11870224

    Find genes that share ontologies with EPHA3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EPHA3 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71


    Find genes that share SuperPaths with EPHA3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    32 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EPHA3 (see first 5)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    P2Y Receptor Signaling
    GSK3 Signaling
    Rho Family GTPases
    Actin Nucleation and Branching
    Activation of PKA through GPCR
    JAK-STAT Pathway
    Estrogen Pathway
    ILK Signaling
    Nanog in Mammalian ESC Pluripotency
    Activation of cAMP-Dependent PKA
    14-3-3 Induced Intracellular Signaling
    MAPK Signaling
    Endothelin-1 Signaling Pathway
    Guidance Cues and Growth Cone Motility
    Ephrin-Eph Signaling
    mTOR Pathway
    EphrinA-EphR Signaling
    eNOS Signaling
    Akt Signaling
    Pancreatic Adenocarcinoma
    CDC42 Pathway
    Actin Nucleation by ARP-WASP Complex
    Breast Cancer Regulation by Stathmin1
    ERK Signaling
    GPCR Pathway
    p38 Signaling
    NFAT in Immune Response
    Ras Pathway

    1 Cell Signaling Technology (CST) Pathway for EPHA3
        Tyrosine Kinases / Adaptors

    3 GeneGo (Thomson Reuters) Pathways for EPHA3
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    2 BioSystems Pathways for EPHA3
        EPHA forward signaling
    EphrinA-EPHA pathway



    1 Kegg Pathway  (Kegg details for EPHA3):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EPHA3
    Interactions:

        GeneGlobe Interaction Network for EPHA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EPHA3 (P293202, 3 ENSP000003374514) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUFY1Q96T512, 3, ENSP000003770944MINT-8032251 MINT-8035980 I2D: score=2 STRING: ENSP00000377094
    CDKN2AP427713, ENSP000003551534I2D: score=1 I2D: score=1 STRING: ENSP00000355153
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    EFNA1P208273, ENSP000003573924I2D: score=2 STRING: ENSP00000357392
    EFNA5P528033, ENSP000003287774I2D: score=2 STRING: ENSP00000328777
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007155cell adhesion IEA--
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----
    GO:0010717regulation of epithelial to mesenchymal transition ISS--
    GO:0010976positive regulation of neuron projection development IMP17910947

    Find genes that share ontologies with EPHA3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EPHA3

    2 HMDB Compounds for EPHA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected Novoseek inferred chemical compound relationships for EPHA3 gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-1 73.8 4 11745395 (1), 17052891 (1), 17932218 (1), 19531477 (1)
    threonine 65.1 24 16641196 (1), 19966577 (1), 20416281 (1), 9405407 (1) (see all 23)
    pd 98,059 59.7 10 18778461 (1), 10925306 (1), 12628005 (1), 14690534 (1) (see all 9)
    tyrosine 57.3 21 1334998 (2), 8188238 (2), 15151996 (1), 18762249 (1) (see all 18)
    serine 55 22 16641196 (1), 19966577 (1), 20416281 (1), 9405407 (1) (see all 22)
    cl 100 52.7 1 15030167 (1)
    sb 203580 50.5 2 18778461 (1), 12589827 (1)
    phosphatidylinositol 48.8 5 14633175 (1), 16322251 (1), 11382770 (1), 12589827 (1) (see all 5)
    phosphoinositide 46.6 8 15468165 (1), 16885398 (1), 16895519 (1), 19920184 (1) (see all 8)
    sp 600125 38.5 3 18778461 (1), 15670787 (1), 12589827 (1)



    Find genes that share compounds with EPHA3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EPHA3 gene (2 alternative transcripts): 
    NM_005233.5  NM_182644.2  

    Unigene Cluster for EPHA3:

    EPH receptor A3
    Hs.123642  [show with all ESTs]
    Unigene Representative Sequence: NM_005233
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336596(uc021xbf.1 uc003dqy.3) ENST00000452448(uc003dqx.1)
    ENST00000494014
    miRNA
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    hsa-miR-411* hsa-miR-323-3p hsa-miR-548j hsa-miR-3607-3p hsa-miR-3653 hsa-miR-550a* hsa-miR-208b hsa-miR-508-5p
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      QuantiFast Probe-based Assays in human, mouse, rat EPHA3

    Additional mRNA sequence: 

    AF213459.1 AF213460.1 AK024352.1 AK291411.1 BC026247.1 BC063282.1 HM437236.1 M83941.1 

    4 DOTS entries:

    DT.97837000  DT.208723  DT.40125530  DT.100662313 

    Selected AceView cDNA sequences (see all 45):

    T28603 BC063282 NM_182644 BC026247 AI918950 AL042479 AF213459 AU137594 
    BE327884 AK024352 NM_005233 AI741389 AU120483 AF213460 BM927323 AU136712 
    BQ003325 BG033947 AI590014 BQ026760 BX441974 AA525961 M85652 AI824661 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EPHA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EPHA3 Expression
    About this image


    EPHA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     NULL (Uncategorized)
             Neural rosettes
    EPHA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EPHA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.123642

    UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320
    Tissue specificity: Widely expressed. Highest level in placenta

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for EPHA3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Epha31 , 5 Eph receptor A31, 5 88.88(n)1
    96.54(a)1
      16 (36.49 cM)5
    138371  NM_010140.31  NP_034270.11 
     635452185 
    chicken
    (Gallus gallus)
    Aves EPHA31 EPH receptor A3 82.23(n)
    92.32(a)
      396402  NM_205430.2  NP_990761.1 
    lizard
    (Anolis carolinensis)
    Reptilia EPHA36
    EPH receptor A3
    88(a)
    1 ↔ 1
    3(166700230-166879358)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia epha31 EPH receptor A3 77.76(n)
    85.15(a)
      100495045  XM_002931773.2  XP_002931819.1 
    zebrafish
    (Danio rerio)
    Actinopterygii epha36
    eph receptor A3
    83(a)
    1 ↔ 1
    9(16828231-16919914) ENSDARG00000039373


    ENSEMBL Gene Tree for EPHA3 (if available)
    TreeFam Gene Tree for EPHA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EPHA3 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHA12  
    EPHB22  EPHA82  EPHA72  EPHA102  EPHB42  
    Selected SIMAP similar genes for EPHA3 using alignment to 4 protein entries:     EPHA3_HUMAN (see all proteins) (see all similar genes):
    EPHA6    EPHA4    EPHA7    EPHA5    EPHB1    EPHB2 variant protein
    EPHA8    EPHB2    EPHB3    EPHA2    ABL1    FGR
    EPHA10    FES    FYN    EPHB4    SRC    HCK

    Find genes that share paralogs with EPHA3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EPHA3 (see all 7038)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2005678881,2,,4
    CA pancreatic ductal adenocarcinoma sample4 --89212355(+) GTGAAG/TAATCT 4 K N mis10--------
    VAR_0658324
    A lung carcinoma sample4--see VAR_0658322 T M mis40--------
    VAR_0421264
    A lung large cell carcinoma sample4--see VAR_0421262 S Y mis40--------
    VAR_0360894
    A colorectal cancer sample4--see VAR_0360892 D N mis40--------
    VAR_0421324
    A lung adenocarcinoma sample4--see VAR_0421322 G E mis40--------
    VAR_0360874
    A colorectal cancer sample4--see VAR_0360872 N S mis40--------
    VAR_0421284
    A lung squamous cell carcinoma sample4--see VAR_0421282 G L mis40--------
    VAR_0360864
    A colorectal cancer sample4--see VAR_0360862 T K mis40--------
    VAR_0360884
    A colorectal cancer sample4--see VAR_0360882 I L mis40--------
    VAR_0421274
    A lung neuroendocrine carcinoma sample4--see VAR_0421272 S F mis40--------

    HapMap Linkage Disequilibrium report for EPHA3 (89156674 - 89406674 bp, first 250kb of EPHA3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EPHA3 (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2490848CNV Deletion19546169
    esv2667696CNV Deletion23128226
    esv2156570CNV Deletion18987734
    nsv435764CNV Deletion17901297
    esv2421597CNV Deletion20811451
    esv2660172CNV Deletion23128226
    esv2663816CNV Deletion23128226
    esv2725646CNV Deletion23290073
    esv2678650CNV Deletion23128226
    esv273850CNV Insertion20981092

    Human Gene Mutation Database (HGMD): EPHA3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EPHA3
    DNA2.0 Custom Variant and Variant Library Synthesis for EPHA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 179611    OMIM disorders: --

    UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from
    the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with
    progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon
    and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene
    represented in this entry may be involved in disease pathogenesis

  • 2 diseases for EPHA3:    
    About MalaCards
    pleomorphic rhabdomyosarcoma    colorectal cancer


    Find genes that share disorders with EPHA3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for EPHA3 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 51 17 16672981 (1), 17579517 (1), 19703660 (1), 17000703 (1) (see all 16)
    parkinsonism 37.2 10 16226715 (1), 19279012 (1), 17084972 (1), 17620882 (1) (see all 10)
    breast cancer 36.5 15 12151336 (2), 18392133 (2), 16322251 (1), 18650427 (1) (see all 13)
    neurodegeneration 33.3 2 19780893 (1), 20012177 (1)
    neurodegenerative diseases 31.3 1 18334630 (1)
    tumors 30.4 23 10498621 (2), 10987298 (2), 15688034 (1), 16778166 (1) (see all 20)
    cancer 27 8 14760089 (1), 17611497 (1), 12560069 (1), 14530270 (1) (see all 8)
    cardiac hypertrophy 11 1 18054038 (1)
    uveal melanoma 7.57 1 16845324 (1)
    necrosis 6.62 3 15523691 (1), 19298660 (1), 12889600 (1)

    Genetic Association Database (GAD): EPHA3
    Human Genome Epidemiology (HuGE) Navigator: EPHA3 (5 documents)

    Export disorders for EPHA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EPHA3 gene, integrated from 10 sources (see all 482):
    (articles sorted by number of sources associating them with EPHA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines. (PubMed id 1311845)1, 2, 3 Wicks I.P.... Boyd A.W. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line. (PubMed id 1737782)1, 2, 3 Boyd A.W.... Busmanis I. (J. Biol. Chem. 1992)
    3. Identification of a tumor-specific shared antigen derived from an Eph receptor and presented to CD4 T cells on HLA class II molecules. (PubMed id 10987298)1, 2, 9 Chiari R....Coulie P.G. (Cancer Res. 2000)
    4. Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3). (PubMed id 18547520)1, 2, 9 Davis T.L.... Dhe-Paganon S. (Structure 2008)
    5. Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas. (PubMed id 20838624)1, 2 Corbo V....Scarpa A. (PLoS ONE 2010)
    6. Genetic mutations associated with cigarette smoking in pancreatic cancer. (PubMed id 19351817)1, 4 Blackford A....Hruban R.H. (Cancer Res. 2009)
    7. Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. (PubMed id 16941478)1, 2 Wood L.D.... Velculescu V.E. (Hum. Mutat. 2006)
    8. Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. (PubMed id 16239146)1, 2 Janes P.W.... Nikolov D.B. (Cell 2005)
    9. Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3- expressing 293T and melanoma cells by CrkII and Rho-mediated signalling. (PubMed id 11870224)1, 2 Lawrenson I.D.... Lackmann M. (J. Cell Sci. 2002)
    10. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2 (Cell 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2042 HGNC: 3387 AceView: EPHA3 Ensembl:ENSG00000044524 euGenes: HUgn2042
    ECgene: EPHA3 Kegg: 2042 H-InvDB: EPHA3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EPHA3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHA3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EPHA3 gene:
    Search GeneIP for patents involving EPHA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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