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EPHA3 Gene

protein-coding   GIFtS: 69
GCID: GC03P089239

EPH Receptor A3

(Previous name: EphA3)
(Previous symbols: ETK, ETK1, TYRO4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
EPH Receptor A31 2     EphA31
ETK11 2 3 5     HEK42
ETK1 2 3     Ephrin Type-A Receptor 32
TYRO41 2 3     Human Embryo Kinase 12
HEK2 3 5     TYRO4 Protein Tyrosine Kinase2
Eph-Like Tyrosine Kinase 12 3     hEK43
Tyrosine-Protein Kinase Receptor ETK12 3     Human Embryo Kinase3
EK42 3     Tyrosine-Protein Kinase TYRO43
EPH-Like Kinase 42 3     EC 2.7.108
EC 2.7.10.13 8     

External Ids:    HGNC: 33871   Entrez Gene: 20422   Ensembl: ENSG000000445247   OMIM: 1796115   UniProtKB: P293203   

Export aliases for EPHA3 gene to outside databases

Previous GC identifers: GC03P089525 GC03P092010 GC03P089036 GC03P089077


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EPHA3 Gene:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related
receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors
in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich
domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity
of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene
encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for EPHA3 Gene:
EPHA3 (EPH receptor A3) is a protein-coding gene. Diseases associated with EPHA3 include pleomorphic rhabdomyosarcoma, and pseudohypoaldosteronism. GO annotations related to this gene include GPI-linked ephrin receptor activity. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320
Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds
preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell
migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the
atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the
retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons
during neuromuscular circuit development

Gene Wiki entry for EPHA3 (EPH receptor A3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EPHA3 gene promoter:
         AP-1   HTF   ATF-2   IRF-7A   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPHA3 promoter sequence
   Search Chromatin IP Primers for EPHA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p11.2   Ensembl cytogenetic band:  3p11.1   HGNC cytogenetic band: 3p11.2

EPHA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHA3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P089239:  view genomic region     (about GC identifiers)

Start:
89,156,674 bp from pter      End:
89,531,284 bp from pter
Size:
374,611 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320 (See protein sequence)
Recommended Name: Ephrin type-A receptor 3 precursor  
Size: 983 amino acids; 110131 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a
receptor dimer. Oligomerization is probably required to induce biological responses. Forms a ternary
EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the
EFNA5-EPHA3 complex internalization and function. Interacts with NCK1 (via SH2 domain); mediates EFNA5-EPHA3
signaling (By similarity). Interacts (phosphorylated) with PTPN1; dephosphorylates EPHA3 and may regulate its
trafficking and function. Interacts (phosphorylated) with CRK; mediates EFNA5-EPHA3 signaling through RHOA GTPase
activation
Selected PDB 3D structures from and Proteopedia for EPHA3 (see all 21):
2GSF (3D)        2QO2 (3D)        2QO7 (3D)        2QO9 (3D)        2QOB (3D)        2QOC (3D)    
Secondary accessions: Q9H2V3 Q9H2V4
Alternative splicing: 2 isoforms:  P29320-1   P29320-2   

Explore the universe of human proteins at neXtProt for EPHA3: NX_P29320

Explore proteomics data for EPHA3 at MOPED

Post-translational modifications: 

  • Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1.
    Dephosphorylated by PTPN11
  • Glycosylation2 at Asn232, Asn337, Asn391, Asn404, Asn493
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for EPHA3 (P29320) (see all 62)
     MSNQDVI  RDLAARN  QNNWLRT  RWTSPEA 


    See EPHA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005224.2  NP_872585.1  

    ENSEMBL proteins: 
     ENSP00000337451   ENSP00000399926   ENSP00000419190  

    EPHA3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for EPHA3
    OriGene MassSpec for EPHA3
    OriGene Custom Protein Services for EPHA3
    GenScript Custom Purified and Recombinant Proteins Services for EPHA3
    Novus Biologicals EPHA3 Proteins
    Novus Biologicals EPHA3 Lysates
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    Sino Biological Cell Lysate for EPHA3
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    Cloud-Clone Corp. Proteins for EPHA3

    EPHA3 Antibody Products:

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    Novus Biologicals EPHA3 Antibodies
    Abcam antibodies for EPHA3 (P54764, P29320, P54756)
    Cloud-Clone Corp. Antibodies for EPHA3
    ThermoFisher Antibodies for EPHA3
    LSBio Antibodies in human, mouse, rat for EPHA3

    EPHA3 Assay Products:

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    GenScript EPHA3-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EPHA3
    Cloud-Clone Corp. CLIAs for EPHA3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor A3
    Ephrin receptor family
    Ephrin receptor family

    Selected InterPro protein domains (see all 18):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P29320

    ProtoNet protein and cluster: P29320

    Selected Blocks protein domains (see all 6):
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    EPHA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHA3_HUMAN, P29320
    Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds
    preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell
    migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the
    atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the
    retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons
    during neuromuscular circuit development
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for EPHA3:
    EPH-related tyrosine kinase receptor binding ephrins A,expressed in projecting neurons and their target
    fields,involved in short-range contact-mediated axonal guidance,expressed by some pre-B and T cell lines,not
    detectable on normal adult human tissues

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0005003ephrin receptor activity ----
    GO:0005004GPI-linked ephrin receptor activity IDA11870224
    GO:0005515protein binding IPI11870224
         
    EPHA3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for EPHA3:
     Decreased substrate adherent c 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Epha3):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  liver/biliary system  mortality/aging 
     respiratory system 

    EPHA3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Epha3tm1Abn for EPHA3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EPHA3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EPHA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPHA3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPHA3

    miRNA
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    Block miRNA regulation of human, mouse, rat EPHA3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EPHA3 (see all 80):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-548j hsa-miR-3607-3p hsa-miR-3653 hsa-miR-550a* hsa-miR-208b hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidEPHA3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EPHA3
    Predesigned siRNA for gene silencing in human, mouse, rat EPHA3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EPHA3

    Clone
    Products:
         
    OriGene clones in human, mouse for EPHA3 (see all 14)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): EPHA3 (NM_005233)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EPHA3_HUMAN, P29320: Isoform 1: Cell membrane; Single-pass type I membrane protein
    EPHA3_HUMAN, P29320: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    extracellular5
    plasma membrane5
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005769early endosome IDA--
    GO:0005887integral component of plasma membrane IDA11870224

    EPHA3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EPHA3 About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EPHA3 (see all 32)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    P2Y Receptor Signaling

    1 Cell Signaling Technology (CST) Pathway for EPHA3
        Tyrosine Kinases / Adaptors

    3 GeneGo (Thomson Reuters) Pathways for EPHA3
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    2 BioSystems Pathways for EPHA3
        EPHA forward signaling
    EphrinA-EPHA pathway



    1 Kegg Pathway  (Kegg details for EPHA3):
        Axon guidance


    EPHA3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EPHA3
    Interactions:

        GeneGlobe Interaction Network for EPHA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EPHA3 (P293202, 3 ENSP000003374514) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUFY1Q96T512, 3, ENSP000003770944MINT-8032251 MINT-8035980 I2D: score=2 STRING: ENSP00000377094
    CDKN2AP427713, ENSP000003551534I2D: score=1 I2D: score=1 STRING: ENSP00000355153
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    EFNA1P208273, ENSP000003573924I2D: score=2 STRING: ENSP00000357392
    EFNA5P528033, ENSP000003287774I2D: score=2 STRING: ENSP00000328777
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007155cell adhesion IEA--
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----
    GO:0010717regulation of epithelial to mesenchymal transition ISS--
    GO:0010976positive regulation of neuron projection development IMP17910947

    EPHA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EPHA3

    2 HMDB Compounds for EPHA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected Novoseek inferred chemical compound relationships for EPHA3 gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-1 73.8 4 11745395 (1), 17052891 (1), 17932218 (1), 19531477 (1)
    threonine 65.1 24 16641196 (1), 19966577 (1), 20416281 (1), 9405407 (1) (see all 23)
    pd 98,059 59.7 10 18778461 (1), 10925306 (1), 12628005 (1), 14690534 (1) (see all 9)
    tyrosine 57.3 21 1334998 (2), 8188238 (2), 15151996 (1), 18762249 (1) (see all 18)
    serine 55 22 16641196 (1), 19966577 (1), 20416281 (1), 9405407 (1) (see all 22)
    cl 100 52.7 1 15030167 (1)
    sb 203580 50.5 2 18778461 (1), 12589827 (1)
    phosphatidylinositol 48.8 5 14633175 (1), 16322251 (1), 11382770 (1), 12589827 (1) (see all 5)
    phosphoinositide 46.6 8 15468165 (1), 16885398 (1), 16895519 (1), 19920184 (1) (see all 8)
    sp 600125 38.5 3 18778461 (1), 15670787 (1), 12589827 (1)



    EPHA3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EPHA3 gene (2 alternative transcripts): 
    NM_005233.5  NM_182644.2  

    Unigene Cluster for EPHA3:

    EPH receptor A3
    Hs.123642  [show with all ESTs]
    Unigene Representative Sequence: NM_005233
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336596(uc021xbf.1 uc003dqy.3) ENST00000452448(uc003dqx.1)
    ENST00000494014

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    hsa-miR-411* hsa-miR-323-3p hsa-miR-548j hsa-miR-3607-3p hsa-miR-3653 hsa-miR-550a* hsa-miR-208b hsa-miR-508-5p
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    GenScript: all cDNA clones in your preferred vector (see all 2): EPHA3 (NM_005233)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA3
    Primer
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    OriGene qPCR primer pairs and template standards for EPHA3
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      QuantiTect SYBR Green Assays in human, mouse, rat EPHA3
      QuantiFast Probe-based Assays in human, mouse, rat EPHA3

    Additional mRNA sequence: 

    AF213459.1 AF213460.1 AK024352.1 AK291411.1 BC026247.1 BC063282.1 HM437236.1 M83941.1 

    4 DOTS entries:

    DT.97837000  DT.208723  DT.40125530  DT.100662313 

    Selected AceView cDNA sequences (see all 45):

    T28603 BC063282 NM_182644 BC026247 AI918950 AL042479 AF213459 AU137594 
    BE327884 AK024352 NM_005233 AI741389 AU120483 AF213460 BM927323 AU136712 
    BQ003325 BG033947 AI590014 BQ026760 BX441974 AA525961 M85652 AI824661 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EPHA3 expression in normal human tissues (normalized intensities)      EPHA3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EPHA3 Expression
    About this image


    EPHA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     NULL (Uncategorized)
             Neural rosettes
    EPHA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EPHA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.123642

    UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320
    Tissue specificity: Widely expressed. Highest level in placenta

        Custom PCR Arrays for EPHA3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EPHA3
    OriGene qSTAR qPCR primer pairs in human, mouse for EPHA3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EPHA3
    QuantiTect SYBR Green Assays in human, mouse, rat EPHA3
    QuantiFast Probe-based Assays in human, mouse, rat EPHA3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for EPHA3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Epha31 , 5 Eph receptor A31, 5 88.88(n)1
    96.54(a)1
      16 (36.49 cM)5
    138371  NM_010140.31  NP_034270.11 
     635452185 
    chicken
    (Gallus gallus)
    Aves EPHA31 EPH receptor A3 82.23(n)
    92.32(a)
      396402  NM_205430.2  NP_990761.1 
    lizard
    (Anolis carolinensis)
    Reptilia EPHA36
    EPH receptor A3
    88(a)
    1 ↔ 1
    3(166700230-166879358)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia epha31 EPH receptor A3 77.76(n)
    85.15(a)
      100495045  XM_002931773.2  XP_002931819.1 
    zebrafish
    (Danio rerio)
    Actinopterygii epha36
    eph receptor A3
    83(a)
    1 ↔ 1
    9(16828231-16919914) ENSDARG00000039373


    ENSEMBL Gene Tree for EPHA3 (if available)
    TreeFam Gene Tree for EPHA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for EPHA3 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHA12  
    EPHB22  EPHA82  EPHA72  EPHA102  EPHB42  
    Selected SIMAP similar genes for EPHA3 using alignment to 4 protein entries:     EPHA3_HUMAN (see all proteins) (see all similar genes):
    EPHA6    EPHA4    EPHA7    EPHA5    EPHB1    EPHB2 variant protein
    EPHA8    EPHB2    EPHB3    EPHA2    ABL1    FGR
    EPHA10    FES    FYN    EPHB4    SRC    HCK

    EPHA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EPHA3 (see all 7038)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2005678881,2,,4
    CA pancreatic ductal adenocarcinoma sample4 --89212355(+) GTGAAG/TAATCT 4 K N mis10--------
    VAR_0658324
    A lung carcinoma sample4--see VAR_0658322 T M mis40--------
    VAR_0421264
    A lung large cell carcinoma sample4--see VAR_0421262 S Y mis40--------
    VAR_0360894
    A colorectal cancer sample4--see VAR_0360892 D N mis40--------
    VAR_0421324
    A lung adenocarcinoma sample4--see VAR_0421322 G E mis40--------
    VAR_0360874
    A colorectal cancer sample4--see VAR_0360872 N S mis40--------
    VAR_0421284
    A lung squamous cell carcinoma sample4--see VAR_0421282 G L mis40--------
    VAR_0360864
    A colorectal cancer sample4--see VAR_0360862 T K mis40--------
    VAR_0360884
    A colorectal cancer sample4--see VAR_0360882 I L mis40--------
    VAR_0421274
    A lung neuroendocrine carcinoma sample4--see VAR_0421272 S F mis40--------

    HapMap Linkage Disequilibrium report for EPHA3 (89156674 - 89406674 bp, first 250kb of EPHA3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EPHA3 (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2490848CNV Deletion19546169
    esv2667696CNV Deletion23128226
    esv2156570CNV Deletion18987734
    nsv435764CNV Deletion17901297
    esv2421597CNV Deletion20811451
    esv2660172CNV Deletion23128226
    esv2663816CNV Deletion23128226
    esv2725646CNV Deletion23290073
    esv2678650CNV Deletion23128226
    esv273850CNV Insertion20981092

    Human Gene Mutation Database (HGMD): EPHA3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EPHA3
    DNA2.0 Custom Variant and Variant Library Synthesis for EPHA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 179611    OMIM disorders: --

    UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from
    the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with
    progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon
    and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene
    represented in this entry may be involved in disease pathogenesis

  • Selected diseases for EPHA3 (see all 46):    About MalaCards
    pleomorphic rhabdomyosarcoma    pseudohypoaldosteronism    familial colorectal cancer    proliferative vitreoretinopathy
    spinal cord injury    rhabdomyosarcoma    parkinson's disease    neurofibromatosis
    cleft palate    hepatitis c    cleft lip    prostate cancer
    duodenitis    retinoblastoma    melanoma    glioblastoma multiforme
    endometriosis    prostatitis    infertility    colorectal cancer


    EPHA3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for EPHA3 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 51 17 16672981 (1), 17579517 (1), 19703660 (1), 17000703 (1) (see all 16)
    parkinsonism 37.2 10 16226715 (1), 19279012 (1), 17084972 (1), 17620882 (1) (see all 10)
    breast cancer 36.5 15 12151336 (2), 18392133 (2), 16322251 (1), 18650427 (1) (see all 13)
    neurodegeneration 33.3 2 19780893 (1), 20012177 (1)
    neurodegenerative diseases 31.3 1 18334630 (1)
    tumors 30.4 23 10498621 (2), 10987298 (2), 15688034 (1), 16778166 (1) (see all 20)
    cancer 27 8 14760089 (1), 17611497 (1), 12560069 (1), 14530270 (1) (see all 8)
    cardiac hypertrophy 11 1 18054038 (1)
    uveal melanoma 7.57 1 16845324 (1)
    necrosis 6.62 3 15523691 (1), 19298660 (1), 12889600 (1)

    Genetic Association Database (GAD): EPHA3
    Human Genome Epidemiology (HuGE) Navigator: EPHA3 (5 documents)

    Export disorders for EPHA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for EPHA3 gene, integrated from 10 sources (see all 482) (see top 10):
    (articles sorted by number of sources associating them with EPHA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines. (PubMed id 1311845)1, 2, 3 Wicks I.P.... Boyd A.W. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line. (PubMed id 1737782)1, 2, 3 Boyd A.W.... Busmanis I. (J. Biol. Chem. 1992)
    3. Identification of a tumor-specific shared antigen derived from an Eph receptor and presented to CD4 T cells on HLA class II molecules. (PubMed id 10987298)1, 2, 9 Chiari R....Coulie P.G. (Cancer Res. 2000)
    4. Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3). (PubMed id 18547520)1, 2, 9 Davis T.L.... Dhe-Paganon S. (Structure 2008)
    5. Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas. (PubMed id 20838624)1, 2 Corbo V....Scarpa A. (PLoS ONE 2010)
    6. Genetic mutations associated with cigarette smoking in pancreatic cancer. (PubMed id 19351817)1, 4 Blackford A....Hruban R.H. (Cancer Res. 2009)
    7. Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. (PubMed id 16941478)1, 2 Wood L.D.... Velculescu V.E. (Hum. Mutat. 2006)
    8. Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. (PubMed id 16239146)1, 2 Janes P.W.... Nikolov D.B. (Cell 2005)
    9. Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3- expressing 293T and melanoma cells by CrkII and Rho-mediated signalling. (PubMed id 11870224)1, 2 Lawrenson I.D.... Lackmann M. (J. Cell Sci. 2002)
    10. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2 (Cell 1997)
    11. Low frequency mutation of the Ephrin receptor A3 gene in hepatocellular carcinoma. (PubMed id 19469653)1, 9 Bae H.J....Nam S.W. (Neoplasma 2009)
    12. The EphA3 receptor is expressed in a subset of rhabdomyosarcoma cell lines and suppresses cell adhesion and migration. (PubMed id 18814179)1, 9 Clifford N....O'Connor R. (J. Cell. Biochem. 2008)
    13. EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion. (PubMed id 14697337)1, 9 Smith L.M....O'Connor R. (Exp. Cell Res. 2004)
    14. Localization of a human receptor tyrosine kinase (ETK1) to chromosome region 3p11.2. (PubMed id 8188238)1, 9 Wicks I.P....Sutherland G.R. (Genomics 1994)
    15. Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3. (PubMed id 15901737)2, 9 Day B....Lackmann M. (J. Biol. Chem. 2005)
    16. Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases. (PubMed id 19678838)1, 9 Davis T.L....Dhe-Paganon S. (FEBS J. 2009)
    17. Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro. (PubMed id 9751130)1, 9 Ciossek T....Drescher U. (Eur. J. Neurosci. 1998)
    18. Mechanisms involved in development of retinotectal connections: roles of Eph receptor tyrosine kinases, NMDA receptors and nitric oxide. (PubMed id 9932438)1, 9 Ernst A.F....McLoon S.C. (Prog. Brain Res. 1998)
    19. EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme. (PubMed id 23410976)1 Day B.W....Boyd A.W. (Cancer Cell 2013)
    20. A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. (PubMed id 23324396)1 Lahtela J....Verschuren E.W. (Cell Cycle 2013)
    21. Genome-wide association study of chronic periodontitis in a general German population. (PubMed id 24024966)1 Teumer A....Kocher T. (J. Clin. Periodontol. 2013)
    22. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    23. Aberrant expression of EphA3 in gastric carcinoma: correlation with tumor angiogenesis and survival. (PubMed id 22350700)1 Xi H.Q....Chen L. (J. Gastroenterol. 2012)
    24. Effects of cancer-associated EPHA3 mutations on lung cancer. (PubMed id 22829656)1 Zhuang G....Chen J. (J. Natl. Cancer Inst. 2012)
    25. Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms. (PubMed id 22242939)1 Lisabeth E.M....Pasquale E.B. (Biochemistry 2012)
    26. Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. (PubMed id 22863734)1 Ludwig K.U....NAPthen M.M. (Nat. Genet. 2012)
    27. Clinicopathological significance and prognostic value of EphA3 and CD133 expression in colorectal carcinoma. (PubMed id 21415057)1 Xi H.Q. and Zhao P. (J. Clin. Pathol. 2011)
    28. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    29. Copy number variations of EphA3 are associated with multiple types of hematologic malignancies. (PubMed id 21454190)1 Guan M....Zhang W. (amp 2011)
    30. Sperry versus Hebb: topographic mapping in Isl2/EphA3 mutant mice. (PubMed id 21190559)1 Tsigankov D. and Koulakov A.A. (BMC Neurosci 2010)
    31. Exploring the link between germline and somatic genetic alterations in breast carcinogenesis. (PubMed id 21124932)1 Bonifaci N....Pujana M.A. (PLoS ONE 2010)
    32. Multiple tumor-suppressor genes on chromosome 3p contribute to head and neck squamous cell carcinoma tumorigenesis. (PubMed id 20657180)1 Lee D.J....Su G.H. (amp 2010)
    33. PTP1B regulates Eph receptor function and trafficking. (PubMed id 21135139)2 Nievergall E.... Lackmann M. (J. Cell Biol. 2010)
    34. Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells. (PubMed id 18385452)1 Wimmer-Kleikamp S.H....Lackmann M. (Blood 2008)
    35. Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. (PubMed id 18463370)4 Maris J.M....Hakonarson H. (N. Engl. J. Med. 2008)
    36. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    37. Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen. (PubMed id 17910947)1 Yamada S....Miyake J. (Biochem. Biophys. Res. Commun. 2007)
    38. Proteomic analysis of p16ink4a-binding proteins. (PubMed id 17955473)1 Souza-RodrA-gues E....Jaumot M. (Proteomics 2007)
    39. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    40. Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)1 Wissing J....Daub H. (amp 2007)
    41. The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs. (PubMed id 16186805)1 Xie Y.... Qiu Y. (Oncogene 2006)
    42. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    43. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    44. An unappreciated role for RNA surveillance. (PubMed id 14759258)1 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    45. Dissecting the EphA3/Ephrin-A5 interactions using a novel functional mutagenesis screen. (PubMed id 14660665)2 Smith F.M.... Boyd A.W. (J. Biol. Chem. 2004)
    46. Bi-directional regulation between tyrosine kinase Etk/BMX and tumor suppressor p53 in response to DNA damage. (PubMed id 15355990)1 Jiang T....Qiu Y. (J. Biol. Chem. 2004)
    47. Interaction between tyrosine kinase Etk and a RUN-domain and FYVE- domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking. (PubMed id 11877430)1 Yang J.... Qiu Y. (J. Biol. Chem. 2002)
    48. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    49. Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor. (PubMed id 11494128)1 Yu H.H....Pasquale E.B. (Oncogene 2001)
    50. Multiple roles of EPH receptors and ephrins in neural development. (PubMed id 11256076)1 Wilkinson D.G. (Nat. Rev. Neurosci. 2001)
    51. Roles of Eph receptors and ephrins in segmental patterning. (PubMed id 11128993)1 Xu Q....Wilkinson D.G. (Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2000)
    52. Eph receptors and ephrins: regulators of guidance and assembly. (PubMed id 10730216)1 Wilkinson D.G. (Int. Rev. Cytol. 2000)
    53. Eph receptors and ephrins: effectors of morphogenesis. (PubMed id 10207129)1 Holder N. and Klein R. (Development 1999)
    54. Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization. (PubMed id 9685371)1 Lackmann M....Boyd A.W. (J. Biol. Chem. 1998)
    55. Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region. (PubMed id 9632142)1 Zisch A.H....Pasquale E.B. (Oncogene 1998)
    56. The Eph family receptors and ligands. (PubMed id 9576626)1 Zhou R. (amp 1998)
    57. The ephrins and Eph receptors in neural development. (PubMed id 9530499)1 Flanagan J.G. and Vanderhaeghen P. (Annu. Rev. Neurosci. 1998)
    58. LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain. (PubMed id 9245480)1 Kozlosky C.J....Carpenter M.K. (Cytokine 1997)
    59. Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor. (PubMed id 9195962)1 Lackmann M....Boyd A.W. (J. Biol. Chem. 1997)
    60. Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases. (PubMed id 8559144)1 Cerretti D.P.... Fletcher R.A. (Mol. Immunol. 1995)
    61. Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors. (PubMed id 8070404)1 Beckmann M.P.... Lyman S.D. (EMBO J. 1994)
    62. Different clinical roles for p21-activated kinase-1 in primary and recurrent ovarian carcinoma. (PubMed id 18656238)9 Davidson B....Wang T.L. (Hum. Pathol. 2008)
    63. EphA3 null mutants do not demonstrate motor axon guidance defects. (PubMed id 14585969)9 Vaidya A....Brown A. (Mol. Cell. Biol. 2003)
    64. Cloning and characterization of EphA3 (Hek) gene promoter: DNA methylation regulates expression in hematopoietic tumor cells. (PubMed id 10498621)9 Dottori M....Boyd A.W. (Blood 1999)
    65. Concurrent binding of anti-EphA3 antibody and ephrin-A5 amplifies EphA3 signaling and downstream responses: potential as EphA3-specific tumor-targeting reagents. (PubMed id 16061656)9 Vearing C....Lackmann M. (Cancer Res. 2005)
    66. Regulatory interrelations among topographic molecules CBF1, CBF2 and EphA3 in the developing chick retina. (PubMed id 10545030)9 Yamagata M....Noda M. (amp 1999)
    67. Silencing of EphA3 through a cis interaction with ephrinA5. (PubMed id 16491080)9 Carvalho R.F....Drescher U. (Nat. Neurosci. 2006)
    68. Upregulation of EphA3 receptor after spinal cord injury. (PubMed id 16083359)9 Irizarry-RamA-rez M....Miranda J.D. (J. Neurotrauma 2005)
    69. Two homeobox genes define the domain of EphA3 expression in the developing chick retina. (PubMed id 11060230)9 Schulte D. and Cepko C.L. (Development 2000)
    70. Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. (PubMed id 18794135)9 Sherk A.B....McDonnell D.P. (Cancer Res. 2008)
    71. Rho GTPases and p21-activated kinase in the regulation of proliferation and apoptosis by gastrins. (PubMed id 18565785)9 He H. and Baldwin G.S. (amp 2008)
    72. Potential clinical relevance of Eph receptors and ephrin ligands expressed in prostate carcinoma cell lines. (PubMed id 16516143)9 Fox B.P....Kandpal R.P. (Biochem. Biophys. Res. Commun. 2006)
    73. High EphA3 expressing ophthalmic trigeminal sensory axons are sensitive to ephrin-A5-Fc: implications for lobe specific axon guidance. (PubMed id 16054765)9 Jayasena C.S....Koblar S.A. (Neuroscience 2005)
    74. Activation of c-Jun N-terminal kinase in A549 lung carcinoma cells by sodium dichromate: role of dissociation of apoptosis signal regulating kinase-1 from its physiological inhibitor thioredoxin. (PubMed id 15003321)9 Hodges N.J....Chipman J.K. (Toxicology 2004)
    75. Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1. (PubMed id 10748151)9 King C.C....Bokoch G.M. (J. Biol. Chem. 2000)
    76. Eph receptors and ephrins in the developing chick cerebellum: relationship to sagittal patterning and granule cell migration. (PubMed id 10964955)9 Karam S.D....Bothwell M. (J. Neurosci. 2000)
    77. Constitutive association of TGF-beta-activated kinase 1 with the IkappaB kinase complex in the nucleus and cytoplasm of human neutrophils and its impact on downstream processes. (PubMed id 20200282)9 Ear T....McDonald P.P. (J. Immunol. 2010)
    78. Increased expression of serum- and glucocorticoid-regulated kinase-1 in the duodenal mucosa of children with coeliac disease. (PubMed id 19966577)9 Szebeni B....AratA^ A. (J. Pediatr. Gastroenterol. Nutr. 2010)
    79. Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation. (PubMed id 19406912)9 Haudek S.B....Entman M.L. (Cardiovasc. Res. 2009)
    80. [Effect of p21-activated kinase-1 on the invasiveness of colorectal carcinoma cells in vitro]. (PubMed id 19620048)9 Wu J.B....Song Y.G. (Nan Fang Yi Ke Da Xue Xue Bao 2009)
    81. Pressure-induced vascular oxidative stress is mediated through activation of integrin-linked kinase 1/betaPIX/Rac-1 pathway. (PubMed id 19770407)9 Vecchione C....Lembo G. (Hypertension 2009)
    82. Downregulation of p21-activated kinase-1 inhibits the growth of gastric cancer cells involving cyclin B1. (PubMed id 19610058)9 Liu F....Li F. (Int. J. Cancer 2009)
    83. Down-regulation of p21-activated kinase 1 by progestin and its increased expression in the eutopic endometrium of women with endometriosis. (PubMed id 19168872)9 Kim S.H....Kang B.M. (Hum. Reprod. 2009)
    84. The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics. (PubMed id 19703660)9 Thomas K.J. and Cookson M.R. (amp 2009)
    85. p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. (PubMed id 18392133)9 Li Q....Mattingly R.R. (Neoplasia 2008)
    86. Hsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1. (PubMed id 18456663)9 Belova L....Conzen S.D. (J. Biol. Chem. 2008)
    87. p21-activated kinase 1 promotes soluble mutant huntingtin self-interaction and enhances toxicity. (PubMed id 18065495)9 Luo S....Rubinsztein D.C. (Hum. Mol. Genet. 2008)
    88. MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. (PubMed id 18922890)9 Reddy S.D....Kumar R. (Cancer Res. 2008)
    89. Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1). (PubMed id 18221368)9 Mills R.D....Cheng H.C. (J. Neurochem. 2008)
    90. Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)--&gt;signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3. (PubMed id 18413761)9 Ahmad R....Kufe D. (Cancer Res. 2008)
    91. Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1. (PubMed id 18463232)9 Schuetz F....Adams D.J. (Am. J. Physiol., Cell Physiol. 2008)
    92. High glucose promotes the CTGF expression in human mesangial cells via serum and glucocorticoid-induced kinase 1 pathway. (PubMed id 18846327)9 Wang Q....Zhu Z. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2008)
    93. Sliding p21-activated kinase 1 to nucleus impacts tamoxifen sensitivity. (PubMed id 17604944)9 Rayala S.K. and Kumar R. (amp 2007)
    94. The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity. (PubMed id 17001318)9 Thullberg M....StrAPmblad S. (Oncogene 2007)
    95. Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. (PubMed id 17277159)9 Ahn K.S....Aggarwal B.B. (J. Immunol. 2007)
    96. p21-activated kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in human hepatoma cells. (PubMed id 17255101)9 Ishida H....Lemon S.M. (J. Biol. Chem. 2007)
    97. p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility. (PubMed id 17609315)9 Sheehan K.A....Solaro R.J. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007)
    98. Multiple translational isoforms give functional specificity to serum- and glucocorticoid-induced kinase 1. (PubMed id 17377066)9 Arteaga M.F....Canessa C.M. (Mol. Biol. Cell 2007)
    99. Exclusion of serum- and glucocorticoid-induced kinase 1 (SGK1) as a candidate gene for genetically heterogeneous renal pseudohypoaldosteronism type I in eight families. (PubMed id 17317952)9 Riepe F.G. and Holterhus P.M. (Am. J. Nephrol. 2007)
    100. Role and regulation of the serum- and glucocorticoid-regulated kinase 1 in fertile and infertile human endometrium. (PubMed id 17640988)9 Feroze-Zaidi F....Brosens J.J. (Endocrinology 2007)
    101. Crystal structure of the kinase domain of serum and glucocorticoid- regulated kinase 1 in complex with AMP PNP. (PubMed id 17965184)9 Zhao B.... Schnackenberg C.G. (Protein Sci. 2007)
    102. Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma. (PubMed id 17621631)9 O'Sullivan G.C....Barry O.P. (Int. J. Cancer 2007)
    103. Inhibition of endothelial barrier dysfunction by P21-activated kinase-1. (PubMed id 17612635)9 Ke Y....Solaro R.J. (Can. J. Physiol. Pharmacol. 2007)
    104. Phosphorylation-dependent regulation of stability and transforming potential of ETS transcriptional factor ESE-1 by p21-activated kinase 1. (PubMed id 17491012)9 Manavathi B....Kumar R. (J. Biol. Chem. 2007)
    105. Phosphorylation of RhoGDI by p21-activated kinase 1. (PubMed id 16472651)9 DerMardirossian C.M. and Bokoch G.M. (Meth. Enzymol. 2006)
    106. A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. (PubMed id 17085580)9 Xie M....Schneider M.D. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    107. Ubiquitin-proteasome degradation of serum- and glucocorticoid-regulated kinase-1 (SGK-1) is mediated by the chaperone-dependent E3 ligase CHIP. (PubMed id 16895519)9 Belova L....Conzen S.D. (Biochem. J. 2006)
    108. P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation. (PubMed id 16452229)9 Rayala S.K....Kumar R. (Cancer Res. 2006)
    109. P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts. (PubMed id 16449192)9 Rhee S. and Grinnell F. (J. Cell Biol. 2006)
    110. Apoptosis signal regulating kinase-1 connects reactive oxygen species to p38 MAPK-induced mitochondrial apoptosis in UVB-irradiated human keratinocytes. (PubMed id 17023263)9 Van Laethem A....Agostinis P. (amp 2006)
    111. Activation of the mitogen- and stress-activated kinase 1 by arsenic trioxide. (PubMed id 16762916)9 Kannan-Thulasiraman P....Platanias L.C. (J. Biol. Chem. 2006)
    112. Increased limbic phosphorylated extracellular-regulated kinase 1 and 2 expression after chronic stress is reduced by cyclic 17beta-estradiol administration. (PubMed id 16934944)9 Gerrits M....ter Horst G.J. (Neuroscience 2006)
    113. C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1. (PubMed id 17000703)9 Sim C.H....Cheng H.C. (Hum. Mol. Genet. 2006)
    114. Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3. (PubMed id 16099816)9 Bhalla V....Pearce D. (Mol. Endocrinol. 2005)
    115. STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation. (PubMed id 15764709)9 Kojima H.... Nakajima K. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    116. Identification of dynein light chain 2 as an interaction partner of p21-activated kinase 1. (PubMed id 15845372)9 Lu J....Gu J. (Biochem. Biophys. Res. Commun. 2005)
    117. Nuclear localization and chromatin targets of p21-activated kinase 1. (PubMed id 15749698)9 Singh R.R....Kumar R. (J. Biol. Chem. 2005)
    118. p21-Activated kinase-1 is necessary for depolarization-mediated neuronal survival. (PubMed id 15693023)9 Johnson K. and D'Mello S.R. (J. Neurosci. Res. 2005)
    119. Bradykinin stimulates cell proliferation through an extracellular-regulated kinase 1 and 2-dependent mechanism in breast cancer cells in primary culture. (PubMed id 16079255)9 Greco S....Marsigliante S. (J. Endocrinol. 2005)
    120. Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells. (PubMed id 15066181)9 Jung I.D....Lee H.Y. (Eur. J. Biochem. 2004)
    121. p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. (PubMed id 14970201)9 Zenke F.T....Bokoch G.M. (J. Biol. Chem. 2004)
    122. Toll-like receptor 2 and mitogen- and stress-activated kinase 1 are effectors of Mycobacterium avium-induced cyclooxygenase-2 expression in macrophages. (PubMed id 15496409)9 Pathak S.K....Basu J. (J. Biol. Chem. 2004)
    123. Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. (PubMed id 15153093)9 Hetman M. and Gozdz A. (Eur. J. Biochem. 2004)
    124. p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells. (PubMed id 14530270)9 Balasenthil S....Kumar R. (J. Biol. Chem. 2004)
    125. Modulation of myosin light-chain phosphorylation by p21-activated kinase 1 in Escherichia coli invasion of human brain microvascular endothelial cells. (PubMed id 12704153)9 Rudrabhatla R.S....Prasadarao N.V. (Infect. Immun. 2003)
    126. Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3. (PubMed id 12589052)9 Edlund S.... Landstrom M. (Mol. Biol. Cell 2003)
    127. Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway. (PubMed id 12733988)9 Murthy K.S....Makhlouf G.M. (Biochem. J. 2003)
    128. p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling. (PubMed id 12522133)9 Puto L.A....Bokoch G.M. (J. Biol. Chem. 2003)
    129. Inhibition of mitogen-activated kinase kinase kinase 3 activity through phosphorylation by the serum- and glucocorticoid-induced kinase 1. (PubMed id 12761204)9 Chun J.... Kang S.S. (J. Biochem. 2003)
    130. p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. (PubMed id 12151336)9 Li F....Kumar R. (EMBO Rep. 2002)
    131. Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1. (PubMed id 11813163)9 Marinari B....Tuosto L. (Eur. J. Immunol. 2002)
    132. p21-activated kinase 1 activates the nuclear factor kappa B (NF-kappa B)-inducing kinase-Ikappa B kinases NF-kappa B pathway and proinflammatory cytokines in Helicobacter pylori infection. (PubMed id 11016939)9 Foryst-Ludwig A. and Naumann M. (J. Biol. Chem. 2000)
    133. p21-activated kinase 1 plays a critical role in cellular activation by Nef. (PubMed id 10713183)9 Fackler O.T....Peterlin B.M. (Mol. Cell. Biol. 2000)
    134. Expression of Eph receptor tyrosine kinases and their ligands in chick embryonic motor neurons and hindlimb muscles. (PubMed id 10646798)9 Iwamasa H....Tanaka H. (amp 1999)
    135. A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1. (PubMed id 10471813)9 Koyano S....Yoshioka K. (FEBS Lett. 1999)
    136. Molecular evidence for the early specification of presumptive functional domains in the embryonic primate cerebral cortex. (PubMed id 10407035)9 Donoghue M.J. and Rakic P. (J. Neurosci. 1999)
    137. Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1. (PubMed id 9639556)9 Cuenda A. and Dorow D.S. (Biochem. J. 1998)
    138. Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. (PubMed id 9451000)9 Daniels R.H....Bokoch G.M. (EMBO J. 1998)
    139. Endothelin-1 stimulates tyrosine phosphorylation and the activities of two mitogen-activated protein kinases in cultured vascular smooth muscle cells. (PubMed id 1334998)9 Koide M....Yokoyama M. (J. Hypertens. 1992)
    140. Angiotensin II stimulates two myelin basic protein/microtubule-associated protein 2 kinases in cultured vascular smooth muscle cells. (PubMed id 1323434)9 Tsuda T....Yokoyama M. (Circ. Res. 1992)
    141. LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain. (PubMed id 20400510)9 Deguchi A....Taketo M.M. (J. Biol. Chem. 2010)
    142. mTOR complex-2 activates ENaC by phosphorylating SGK1. (PubMed id 20338997)9 Lu M.... Pearce D. (J. Am. Soc. Nephrol. 2010)
    143. Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians. (PubMed id 20185809)9 Bian L....Bogardus C. (Diabetes 2010)
    144. Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells. (PubMed id 20416281)9 Murakami Y....Ono M. (Biochem. Biophys. Res. Commun. 2010)
    145. Estrogen receptor-alpha phosphorylation at serine 305, nuclear p21-activated kinase 1 expression, and response to tamoxifen in postmenopausal breast cancer. (PubMed id 20179234)9 Bostner J....StAYl O. (Clin. Cancer Res. 2010)
    146. Tickled PINK1: mitochondrial homeostasis and autophagy in recessive Parkinsonism. (PubMed id 19595762)9 Chu C.T. (Biochim. Biophys. Acta 2010)
    147. Prognostic significance of integrin-linked kinase1 overexpression in astrocytoma. (PubMed id 19676046)9 Li J....Li M. (Int. J. Cancer 2010)
    148. Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+-induced ERK1/2 and PKB phosphorylation. (PubMed id 19946718)9 Pandey N.R....Srivastava A.K. (J. Biol. Inorg. Chem. 2010)
    149. Hunting for serine 276-phosphorylated p65. (PubMed id 20204068)9 Spooren A....Gerlo S. (amp 2010)
    150. BAK7 displays unequal genetic redundancy with BAK1 in brassinosteroid signaling and early senescence in Arabidopsis. (PubMed id 20108170)9 Jeong Y.J....Nam K.H. (Mol. Cells 2010)
    151. Formation of parkin aggregates and enhanced PINK1 accumulation during the pathogenesis of Parkinson's disease. (PubMed id 20171192)9 Um J.W....Chung K.C. (Biochem. Biophys. Res. Commun. 2010)
    152. Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1. (PubMed id 19410195)9 Brems H....Legius E. (Lancet Oncol. 2009)
    153. Uptake of plasmid-loaded nanoparticles in breast cancer cells and effect on Plk1 expression. (PubMed id 19591537)9 Steinhauser I....SpAonkuch B. (J Drug Target 2009)
    154. Deoxypodophyllotoxin, flavolignan, from Anthriscus sylvestris Hoffm. inhibits migration and MMP-9 via MAPK pathways in TNF-alpha-induced HASMC. (PubMed id 19013539)9 Suh S.J....Kim C.H. (Vascul. Pharmacol. 2009)
    155. Mitochondrial autophagy as a compensatory response to PINK1 deficiency. (PubMed id 19786829)9 Cherra S.J....Chu C.T. (Autophagy 2009)
    156. Neutrophil elastase cleaves VEGF to generate a VEGF fragment with altered activity. (PubMed id 19136576)9 Kurtagic E....Nugent M.A. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009)
    157. Epithelial sodium channel regulated by differential composition of a signaling complex. (PubMed id 19380724)9 Soundararajan R....Pearce D. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    158. Role of p47(phox) in regulating Cdc42GAP, vimentin, and contraction in smooth muscle cells. (PubMed id 19812368)9 Li Q.F. and Tang D.D. (Am. J. Physiol., Cell Physiol. 2009)
    159. miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia. (PubMed id 19258499)9 Pigazzi M....Basso G. (Cancer Res. 2009)
    160. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. (PubMed id 19279012)9 Dagda R.K....Chu C.T. (J. Biol. Chem. 2009)
    161. SGK1 activity in Na+ absorbing airway epithelial cells monitored by assaying NDRG1-Thr346/356/366 phosphorylation. (PubMed id 18787837)9 Inglis S.K.... Wilson S.M. (Pflugers Arch. 2009)
    162. X-linked inhibitor of apoptosis protein and its E3 ligase activity promote transforming growth factor-{beta}-mediated nuclear factor-{kappa}B activation during breast cancer progression. (PubMed id 19531477)9 Neil J.R....Schiemann W.P. (J. Biol. Chem. 2009)
    163. Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells. (PubMed id 19735704)9 Yang W....Son I.H. (Toxicol. Lett. 2009)
    164. Redox activated MAP kinase death signaling cascade initiated by ASK1 is not activated in female mice following MPTP: novel mechanism of neuroprotection. (PubMed id 19526288)9 Saeed U....Ravindranath V. (Neurotox Res 2009)
    165. Hsp90 transcriptionally and post-translationally regulates the expression of NDRG1 and maintains the stability of its modifying kinase GSK3beta. (PubMed id 19682504)9 Banz V.M....Stroka D. (Biochim. Biophys. Acta 2009)
    166. Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens. (PubMed id 19363496)9 Fan A.C....Felsher D.W. (Nat. Med. 2009)
    167. TNF receptors differentially signal and are differentially expressed and regulated in the human heart. (PubMed id 19788501)9 Al-Lamki R.S....Bradley J.R. (Am. J. Transplant. 2009)
    168. The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process. (PubMed id 19056353)9 Park J....Chung J. (Biochem. Biophys. Res. Commun. 2009)
    169. Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. (PubMed id 19690383)9 Rozansky D.J....Ellison D.H. (J. Clin. Invest. 2009)
    170. Microarray analysis of differentially expressed genes in the brains of tubby mice. (PubMed id 19885003)9 Lee J.H....Ahn Y.S. (amp 2009)
    171. Regulation of a third conserved phosphorylation site in SGK1. (PubMed id 19068477)9 Chen W.... Cobb M.H. (J. Biol. Chem. 2009)
    172. Existence of Pink1 antisense RNAs in mouse and their localization. (PubMed id 20068297)9 Chiba M....Yasue H. (Cytogenet. Genome Res. 2009)
    173. Striking the balance between PTEN and PDK1: it all depends on the cell context. (PubMed id 19651981)9 Iwanami A....Mischel P.S. (amp 2009)
    174. Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis. (PubMed id 20012177)9 Dagda R.K. and Chu C.T. (J. Bioenerg. Biomembr. 2009)
    175. Curcumin suppresses proliferation and invasion in human gastric cancer cells by downregulation of PAK1 activity and cyclin D1 expression. (PubMed id 19448398)9 Cai X.Z....Li F. (amp 2009)
    176. Molecular basis of Parkinson's disease. (PubMed id 19151598)9 Yang Y.X....Latchman D.S. (Neuroreport 2009)
    177. Mitochondrial kinases in Parkinson's disease: converging insights from neurotoxin and genetic models. (PubMed id 19563915)9 Dagda R.K....Chu C.T. (Mitochondrion 2009)
    178. TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA. (PubMed id 19479062)9 Konno H....Inoue J. (PLoS ONE 2009)
    179. A mechanism for the suppression of interleukin-1-induced nuclear factor kappaB activation by protein phosphatase 2Ceta-2. (PubMed id 19594441)9 Henmi T....Kobayashi T. (Biochem. J. 2009)
    180. Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes. (PubMed id 18923061)9 Sheehan K.A....Solaro R.J. (Am. J. Physiol., Cell Physiol. 2009)
    181. Regulation of PINK1 by NR2B-containing NMDA receptors in ischemic neuronal injury. (PubMed id 19780893)9 Shan Y....Wan Q. (J. Neurochem. 2009)
    182. CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1. (PubMed id 19805025)9 Yoon K.W.... Choi E.J. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    183. Tumor necrosis factor-alpha induced expression of matrix metalloproteinase-9 through p21-activated kinase-1. (PubMed id 19298660)9 Zhou L....Han Y.P. (BMC Immunol. 2009)
    184. Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target. (PubMed id 19920184)9 Gu M....Agarwal R. (Cancer Res. 2009)
    185. Regulation of potassium (K) handling in the renal collecting duct. (PubMed id 18839206)9 Wang W.H. and Giebisch G. (Pflugers Arch. 2009)
    186. Dissecting activation of the PAK1 kinase at protrusions in living cells. (PubMed id 19574218)9 Parrini M.C....de Gunzburg J. (J. Biol. Chem. 2009)
    187. Inhibitory effects of adiponectin on platelet-derived growth factor-induced mesangial cell migration. (PubMed id 19460854)9 Ishizawa K....Tamaki T. (J. Endocrinol. 2009)
    188. Urokinase mediates endothelial cell survival via induction of the X-linked inhibitor of apoptosis protein. (PubMed id 18948573)9 Prager G.W....Binder B.R. (Blood 2009)
    189. Protective effect of selenite on renal ischemia/reperfusion injury through inhibiting ASK1-MKK3-p38 signal pathway. (PubMed id 20003709)9 Wang Y....Qiu S.L. (Redox Rep. 2009)
    190. Requirement of JNK-mediated phosphorylation for translocation of group IVA phospholipase A2 to phagosomes in human macrophages. (PubMed id 19625654)9 Casas J....Balboa M.A. (J. Immunol. 2009)
    191. Administration of glucocorticoids to ovarian cancer patients is associated with expression of the anti-apoptotic genes SGK1 and MKP1/DUSP1 in ovarian tissues. (PubMed id 19383827)9 Melhem A....Conzen S.D. (Clin. Cancer Res. 2009)
    192. Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling. (PubMed id 18762249)9 Winkel A....Hoffmann A. (Cell. Signal. 2008)
    193. Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy. (PubMed id 17891170)9 Nieto-Miguel T....Mollinedo F. (Oncogene 2008)
    194. The PINK1/Parkin pathway regulates mitochondrial morphology. (PubMed id 18230723)9 Poole A.C....Pallanck L.J. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    195. Mitogen- and stress-activated kinase 1-mediated histone H3 phosphorylation is crucial for cell transformation. (PubMed id 18381464)9 Kim H.G....Dong Z. (Cancer Res. 2008)
    196. Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer. (PubMed id 18823530)9 Lundgren K....Landberg G. (Breast Cancer Res. 2008)
    197. Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells. (PubMed id 18768391)9 McDaniel A.S....Clapp D.W. (Blood 2008)
    198. Analysis of protein phosphorylation by monolithic extraction columns based on poly(divinylbenzene) containing embedded titanium dioxide and zirconium dioxide nano-powders. (PubMed id 18837466)9 Rainer M....Bonn G.K. (Proteomics 2008)
    199. Protein kinase D1: a new component in TLR9 signaling. (PubMed id 18641342)9 Park J.E....Yi A.K. (J. Immunol. 2008)
    200. Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways. (PubMed id 18778461)9 Nilsson D....MalmsjAP M. (BMC Cardiovasc Disord 2008)
    201. Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration. (PubMed id 19076450)9 Knott A.B. and Bossy-Wetzel E. (Ann. N. Y. Acad. Sci. 2008)
    202. Regulation of epithelial Na+ channels by aldosterone: role of Sgk1. (PubMed id 18197893)9 Lee I.H....Dinudom A. (amp 2008)
    203. Involvement of thioredoxin-binding protein 2 in the antitumor activity of CD437. (PubMed id 19018770)9 Matsuoka S....Shiota G. (Cancer Sci. 2008)
    204. The novel isoflavone 7-hydroxy-3',4'-benzoisoflavone induces cell apoptosis in human osteosarcoma cells. (PubMed id 18606492)9 Hou C.H....Tang C.H. (Cancer Lett. 2008)
    205. 3,4,5-trihydroxybenzaldehyde from Geum japonicum has dual inhibitory effect on matrix metalloproteinase 9; inhibition of gelatinoytic activity as well as MMP-9 expression in TNF-alpha induced HASMC. (PubMed id 18773430)9 Suh S.J....Kim C.H. (J. Cell. Biochem. 2008)
    206. A 39 kDa fragment of endogenous ASK1 suggests specific cleavage not degradation by the proteasome. (PubMed id 18380010)9 Stordal B. and Davey R. (IUBMB Life 2008)
    207. mTORC2 is the hydrophobic motif kinase for SGK1. (PubMed id 19025518)9 Yan L....Lamb R.F. (Biochem. J. 2008)
    208. Antidepressants induce acute CREB phosphorylation and CRE-mediated gene expression in glial cells: a possible contribution to GDNF production. (PubMed id 18234163)9 Hisaoka K....Takebayashi M. (Brain Res. 2008)
    209. The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. (PubMed id 18758450)9 Sorrentino A.... Landstrom M. (Nat. Cell Biol. 2008)
    210. Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism. (PubMed id 18492799)9 Maussion G....Simonneau M. (Hum. Mol. Genet. 2008)
    211. TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaB. (PubMed id 18070982)9 Muroi M. and Tanamoto K. (J. Leukoc. Biol. 2008)
    212. Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells. (PubMed id 18283314)9 Akinmade D....Hamburger A.W. (Br. J. Cancer 2008)
    213. Subversion of CtBP1-controlled macropinocytosis by human adenovirus serotype 3. (PubMed id 18323776)9 Amstutz B....Greber U.F. (EMBO J. 2008)
    214. High D-glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium. (PubMed id 18064606)9 Puebla C....Sobrevia L. (J. Cell. Physiol. 2008)
    215. Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions. (PubMed id 18084006)9 Song C.... Kumar R. (J. Biol. Chem. 2008)
    216. Modulation of ER phosphorylation on serine 118 by endocrine therapy: a new surrogate marker for efficacy. (PubMed id 18436523)9 Zoubir M....Andre F. (Ann. Oncol. 2008)
    217. A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons. (PubMed id 18334630)9 Arteaga M.F.... Canessa C.M. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    218. Induction of serum- and glucocorticoid-induced kinase-1 (SGK1) by cAMP regulates increases in alpha-ENaC. (PubMed id 18615584)9 Vasquez M.M....Mustafa S.B. (J. Cell. Physiol. 2008)
    219. Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. (PubMed id 18054038)9 Mao K....Liang Q. (J. Mol. Cell. Cardiol. 2008)
    220. Transforming growth factor-beta-activated protein kinase 1-binding protein (TAB)-1alpha, but not TAB1beta, mediates cytokine-induced p38 mitogen-activated protein kinase phosphorylation and cell death in insulin-producing cells. (PubMed id 17932218)9 Makeeva N....Welsh N. (Endocrinology 2008)
    221. Regulation Fe65 localization to the nucleus by SGK1 phosphorylation of its Ser566 residue. (PubMed id 18304449)9 Lee E.J....Kang S.S. (BMB Rep. 2008)
    222. PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins. (PubMed id 18515095)9 He H....Baldwin G.S. (Biochim. Biophys. Acta 2008)
    223. [Parkin and mitochondria]. (PubMed id 18717196)9 Mitsui T....Kaji R. (Brain Nerve 2008)
    224. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. (PubMed id 18381444)9 Rhodes N....Kumar R. (Cancer Res. 2008)
    225. RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells. (PubMed id 19015318)9 OrdA^A+ez-MorA!n P....MuA+oz A. (J. Cell Biol. 2008)
    226. N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization. (PubMed id 18215121)9 Garg R....Ridley A.J. (Biochem. J. 2008)
    227. Differential p38 mitogen-activated protein kinase-controlled hypophosphorylation of the retinoblastoma protein induced by nitric oxide in neuroblastoma cells. (PubMed id 17976389)9 GonzA!lez-FernA!ndez O....Villalobo A. (amp 2008)
    228. Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model. (PubMed id 18353870)9 Nishimura H....Matsuo S. (Am. J. Physiol. Renal Physiol. 2008)
    229. Coexistence of mutations in PINK1 and mitochondrial DNA in early onset parkinsonism. (PubMed id 18524835)9 Piccoli C....Capitanio N. (J. Med. Genet. 2008)
    230. Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis. (PubMed id 18160398)9 Roepstorff K....Vilhardt F. (J. Biol. Chem. 2008)
    231. L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner. (PubMed id 18359116)9 Moriwaki Y....Takahashi R. (Neurosci. Res. 2008)
    232. PAMP-triggered immunity: Early events in the activation of FLAGELLIN SENSITIVE2. (PubMed id 19704848)9 Ali G.S. and Reddy A. (amp 2008)
    233. Biochemical and structural characterization of the Pak1-LC8 interaction. (PubMed id 18650427)9 Lightcap C.M....Williams J.C. (J. Biol. Chem. 2008)
    234. The mitochondrial superoxide/thioredoxin-2/Ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes. (PubMed id 17975114)9 Lim P.L....Boelsterli U.A. (Toxicol. Sci. 2008)
    235. Protein kinase C zeta. A novel regulator of both phosphorylation and de-phosphorylation of cardiac sarcomeric proteins. (PubMed id 17724026)9 Wu S.C. and Solaro R.J. (J. Biol. Chem. 2007)
    236. Pseudomonas aeruginosa and sPLA2 IB stimulate ABCA1-mediated phospholipid efflux via ERK-activation of PPARalpha-RXR. (PubMed id 17223797)9 Agassandian M....Mallampalli R.K. (Biochem. J. 2007)
    237. IL-20 gene expression is induced by IL-1beta through mitogen-activated protein kinase and NF-kappaB-dependent mechanisms. (PubMed id 17255956)9 Otkjaer K....Iversen L. (J. Invest. Dermatol. 2007)
    238. Coactivator-mediated estrogen response in human squamous cell carcinoma lines. (PubMed id 17400812)9 Ku T.K. and Crowe D.L. (J. Endocrinol. 2007)
    239. Dynamic interplay between nitration and phosphorylation of tubulin cofactor B in the control of microtubule dynamics. (PubMed id 18048340)9 Rayala S.K....Kumar R. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    240. TAB1 modulates IL-1alpha mediated cytokine secretion but is dispensable for TAK1 activation. (PubMed id 17052891)9 Bertelsen M. and Sanfridson A. (Cell. Signal. 2007)
    241. Chemoresistance of endothelial cells induced by basic fibroblast growth factor depends on Raf-1-mediated inhibition of the proapoptotic kinase, ASK1. (PubMed id 17363598)9 Alavi A.S....Cheresh D.A. (Cancer Res. 2007)
    242. Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease. (PubMed id 17499497)9 Dodson M.W. and Guo M. (Curr. Opin. Neurobiol. 2007)
    243. Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide. (PubMed id 17348859)9 Windheim M....Cohen P. (Biochem. J. 2007)
    244. Possible implications of redox-sensitive tumour cell transformation; lessons from cell culture studies. (PubMed id 17882938)9 Orzechowski A. (Pol J Vet Sci 2007)
    245. Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation. (PubMed id 17505005)9 Bhutani M....Aggarwal B.B. (Clin. Cancer Res. 2007)
    246. Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase. (PubMed id 17420447)9 Acconcia F....Kumar R. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    247. TAK1 represses transcription of the human telomerase reverse transcriptase gene. (PubMed id 17325661)9 Fujiki T....Katakura Y. (Oncogene 2007)
    248. Inhibition of Galphaq-dependent PLC-beta1 activity by PKG and PKA is mediated by phosphorylation of RGS4 and GRK2. (PubMed id 16885398)9 Huang J....Murthy K.S. (Am. J. Physiol., Cell Physiol. 2007)
    249. Heregulin-mediated ErbB2-ERK signaling activates hyaluronan synthases leading to CD44-dependent ovarian tumor cell growth and migration. (PubMed id 17493932)9 Bourguignon L.Y....Peyrollier K. (J. Biol. Chem. 2007)
    250. Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer. (PubMed id 17486065)9 Bostner J....StAYl O. (Oncogene 2007)
    251. PINK1 mutation heterozygosity and the risk of Parkinson's disease. (PubMed id 17172567)9 Toft M....Farrer M.J. (J. Neurol. Neurosurg. Psychiatr. 2007)
    252. Effect of exercise and insulin on SREBP-1c expression in human skeletal muscle: potential roles for the ERK1/2 and Akt signalling pathways. (PubMed id 17956338)9 Boonsong T....Tsintzas K. (Biochem. Soc. Trans. 2007)
    253. Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IkappaB kinase in hepatic macrophages. (PubMed id 17172471)9 Chen L....Tsukamoto H. (J. Biol. Chem. 2007)
    254. The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function. (PubMed id 17362513)9 Scheele C....Timmons J.A. (BMC Genomics 2007)
    255. PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c. (PubMed id 17707122)9 Wang H.L....Yu S.T. (Neurobiol. Dis. 2007)
    256. Nitric oxide down-regulates polo-like kinase 1 through a proximal promoter cell cycle gene homology region. (PubMed id 17121839)9 Zhang J....Danner R.L. (J. Biol. Chem. 2007)
    257. 17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines. (PubMed id 17308059)9 Mitchell C....Dent P. (Mol. Cancer Ther. 2007)
    258. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. (PubMed id 17611497)9 Carpten J.D.... Thomas J.E. (Nature 2007)
    259. Spinal cord injury induces endoplasmic reticulum stress with different cell-type dependent response. (PubMed id 17578450)9 Penas C....Casas C. (J. Neurochem. 2007)
    260. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. (PubMed id 17563363)9 Kitada T....Shen J. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    261. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. (PubMed id 17579517)9 Pridgeon J.W....Li L. (PLoS Biol. 2007)
    262. DJ-1: a newcomer in Parkinson's disease pathology. (PubMed id 18045143)9 da Costa C.A. (Curr. Mol. Med. 2007)
    263. Contrasting roles of neuronal Msk1 and Rsk2 in Bad phosphorylation and feedback regulation of Erk signalling. (PubMed id 17663748)9 Clark C.J....Morris B.J. (J. Neurochem. 2007)
    264. A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion. (PubMed id 17997827)9 Mitsios N....Slevin M. (BMC Neurosci 2007)
    265. Lim kinases, regulators of actin dynamics. (PubMed id 17188549)9 Bernard O. (Int. J. Biochem. Cell Biol. 2007)
    266. Impact of recent genetic findings in Parkinson's disease. (PubMed id 17620882)9 Klein C. and Lohmann-Hedrich K. (Curr. Opin. Neurol. 2007)
    267. Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS. (PubMed id 17117922)9 McCoy C.E.... Arthur J.S. (Biochem. J. 2007)
    268. PKC-alpha and TAK-1 are intermediates in the activation of c-Jun NH2-terminal kinase by hypoxia-reoxygenation. (PubMed id 17209006)9 Frazier D.P....Webster K.A. (Am. J. Physiol. Heart Circ. Physiol. 2007)
    269. Salt, sodium channels, and SGK1. (PubMed id 17332888)9 Pearce D. and Kleyman T.R. (J. Clin. Invest. 2007)
    270. A critical review of the therapeutic potential of dibenzyl trisulphide isolated from Petiveria alliacea L (guinea hen weed, anamu). (PubMed id 17621839)9 Williams L.A....Barton E.N. (West Indian Med J 2007)
    271. Phosphorylated Pak1 level in the cytoplasm correlates with shorter survival time in patients with glioblastoma. (PubMed id 18006760)9 Aoki H....Kondo Y. (Clin. Cancer Res. 2007)
    272. Requirement for both JAK-mediated PI3K signaling and ACT1/TRAF6/TAK1-dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells. (PubMed id 17982039)9 Huang F....Wu R. (J. Immunol. 2007)
    273. Candida albicans triggers activation of distinct signaling pathways to establish a proinflammatory gene expression program in primary human endothelial cells. (PubMed id 18056390)9 MA1ller V....Goebeler M. (J. Immunol. 2007)
    274. TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells. (PubMed id 16492740)9 Gerbod-Giannone M.C....Tall A.R. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    275. Association of PINK1 and DJ-1 confers digenic inheritance of early- onset Parkinson's disease. (PubMed id 16632486)9 Tang B.... Zhang Z. (Hum. Mol. Genet. 2006)
    276. Assessment of PINK1 (PARK6) polymorphisms in Finnish PD. (PubMed id 16046032)9 ClarimA^n J....Singleton A.B. (Neurobiol. Aging 2006)
    277. Sphingosine-1-phosphate acts via rho-associated kinase and nitric oxide to regulate human placental vascular tone. (PubMed id 16162874)9 Hemmings D.G....Taggart M.J. (Biol. Reprod. 2006)
    278. PAK1 hyperactivation is sufficient for mammary gland tumor formation. (PubMed id 16331248)9 Wang R.A....Kumar R. (Oncogene 2006)
    279. Melanoma genomics reveals signatures of sensitivity to bio- and targeted therapies. (PubMed id 17433276)9 TA-mA!r J....RA!sA^ E. (Cell. Immunol. 2006)
    280. Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides. (PubMed id 16537514)9 Schirmer A....Santi D.V. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    281. Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors. (PubMed id 16790082)9 Goldstein M....Orr-Urtreger A. (Neoplasia 2006)
    282. Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients. (PubMed id 16705121)9 Holm C....Landberg G. (J. Natl. Cancer Inst. 2006)
    283. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. (PubMed id 16672981)9 Clark I.E....Guo M. (Nature 2006)
    284. The PAK1 autoregulatory domain is required for interaction with NIK in Helicobacter pylori-induced NF-kappaB activation. (PubMed id 16497167)9 Neumann M....Naumann M. (Biol. Chem. 2006)
    285. Hsp90 increases LIM kinase activity by promoting its homo- dimerization. (PubMed id 16641196)9 Li R.... Bernard O. (FASEB J. 2006)
    286. An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway. (PubMed id 17110930)9 Nakajima A....Nakano H. (EMBO J. 2006)
    287. Increased p21-activated kinase-1 expression is associated with invasive potential in uveal melanoma. (PubMed id 16845324)9 Pavey S....Hayward N. (Melanoma Res. 2006)
    288. Prostate-specific membrane antigen regulates angiogenesis by modulating integrin signal transduction. (PubMed id 16809768)9 Conway R.E....Shapiro L.H. (Mol. Cell. Biol. 2006)
    289. PAK1 and aPKCzeta regulate myosin II-B phosphorylation: a novel signaling pathway regulating filament assembly. (PubMed id 16611744)9 Even-Faitelson L. and Ravid S. (Mol. Biol. Cell 2006)
    290. Induction of apoptosis by p110C requires mitochondrial translocation of the proapoptotic BCL-2 family member BAD. (PubMed id 16413544)9 Chen C....Gu J. (FEBS Lett. 2006)
    291. Xenopus death-domain-containing proteins FADD and RIP1 synergistically activate JNK and NF-kappaB. (PubMed id 16597320)9 Ishizawa Y.H....Ito M. (Biol. Cell 2006)
    292. Tumor inhibition by genomically integrated inducible RNAi-cassettes. (PubMed id 16945954)9 Kappel S....Strebhardt K. (Nucleic Acids Res. 2006)
    293. Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis. (PubMed id 16262601)9 Cao H.... Blackshear P.J. (Biochem. J. 2006)
    294. Role of Rac1 in Escherichia coli K1 invasion of human brain microvascular endothelial cells. (PubMed id 16243562)9 Rudrabhatla R.S....Prasadarao N.V. (Microbes Infect. 2006)
    295. [A 62-year-old woman with early-onset Parkinson's disease associated with the PINKi gene deletion]. (PubMed id 16642930)9 Atsumi M....Hattori N. (Rinsho Shinkeigaku 2006)
    296. A common A340T variant in PINK1 gene associated with late-onset Parkinson's disease in Chinese. (PubMed id 17084972)9 Wang F....Chan P. (Neurosci. Lett. 2006)
    297. MyD88 and TNF receptor-associated factor 6 are critical signal transducers in Helicobacter pylori-infected human epithelial cells. (PubMed id 16517750)9 Hirata Y....Omata M. (J. Immunol. 2006)
    298. Comparative integromics on Eph family. (PubMed id 16596241)9 Katoh M. and Katoh M. (Int. J. Oncol. 2006)
    299. Putative dual role of ephrin-Eph receptor interactions in inflammation. (PubMed id 16801213)9 Ivanov A.I. and Romanovsky A.A. (IUBMB Life 2006)
    300. Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on TNF-alpha-induced matrix metalloproteinase-9 production and HASMC migration via down-regulated NF-kappaB and AP-1. (PubMed id 16999937)9 Suh S.J....Kim C.H. (Biochem. Pharmacol. 2006)
    301. Nuclear p21-activated kinase 1 in breast cancer packs off tamoxifen sensitivity. (PubMed id 16778166)9 Rayala S.K....Kumar R. (Cancer Res. 2006)
    302. Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells. (PubMed id 16532036)9 Mochizuki T....Kamata T. (Oncogene 2006)
    303. Integrin alphaVbeta3 contains a receptor site for resveratrol. (PubMed id 16790523)9 Lin H.Y....Davis P.J. (FASEB J. 2006)
    304. Mitogen- and stress-activated protein kinase 1 is critical for interleukin-1-induced, CREB-mediated, c-fos gene expression in keratinocytes. (PubMed id 16532028)9 Schiller M....Mauviel A. (Oncogene 2006)
    305. A Phosphatidylinositol 3-kinase-regulated Akt-independent signaling promotes cigarette smoke-induced FRA-1 expression. (PubMed id 16490785)9 Zhang Q....Reddy S.P. (J. Biol. Chem. 2006)
    306. Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex. (PubMed id 16543409)9 FrobA...Billestrup N. (Mol. Endocrinol. 2006)
    307. SGK1 activates Na+-K+-ATPase in amphibian renal epithelial cells. (PubMed id 16192298)9 Alvarez de la Rosa D....Canessa C.M. (Am. J. Physiol., Cell Physiol. 2006)
    308. Glucocorticoid receptor activation signals through forkhead transcription factor 3a in breast cancer cells. (PubMed id 16690749)9 Wu W....Conzen S.D. (Mol. Endocrinol. 2006)
    309. Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages. (PubMed id 16365431)9 Sekine Y....Matsuda T. (J. Immunol. 2006)
    310. Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via preferential activation of the PI3K/ILK pathway. (PubMed id 16472257)9 Huang J....Murthy K.S. (Biochem. J. 2006)
    311. Vasoactive intestinal peptide induces neuroendocrine differentiation in the LNCaP prostate cancer cell line through PKA, ERK, and PI3K. (PubMed id 15468165)9 GutiAcrrez-CaA+as I....Carmena M.J. (Prostate 2005)
    312. Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells. (PubMed id 16322251)9 Asanuma H....Sato N. (Cancer Res. 2005)
    313. TGF beta signalling and its role in tumour pathogenesis. (PubMed id 15990918)9 Kaminska B....Danilkiewicz M. (Acta Biochim. Pol. 2005)
    314. Subcellular targeting of oxidants during endothelial cell migration. (PubMed id 16330715)9 Wu R.F.... Terada L.S. (J. Cell Biol. 2005)
    315. Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. (PubMed id 15864311)9 Phee H....Weiss A. (Nat. Immunol. 2005)
    316. Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection. (PubMed id 15688034)9 Fan S....Rosen E.M. (Oncogene 2005)
    317. TNFR1- and TNFR2-mediated signaling pathways in human kidney are cell type-specific and differentially contribute to renal injury. (PubMed id 16195372)9 Al-Lamki R.S....Bradley J.R. (FASEB J. 2005)
    318. Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y. (PubMed id 16226715)9 Deng H....Le W. (Biochem. Biophys. Res. Commun. 2005)
    319. Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes. (PubMed id 15713122)9 Hers I. and TavarAc J.M. (Biochem. J. 2005)
    320. Angiotensin II-induced activation of p21-activated kinase 1 requires Ca2+ and protein kinase C{delta} in vascular smooth muscle cells. (PubMed id 16033904)9 Woolfolk E.A....Motley E.D. (Am. J. Physiol., Cell Physiol. 2005)
    321. Sgk1, a cell survival response in neurodegenerative diseases. (PubMed id 16125969)9 Schoenebeck B....Stichel C.C. (Mol. Cell. Neurosci. 2005)
    322. Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine. (PubMed id 15766329)9 Tang D.D....Gunst S.J. (Biochem. J. 2005)
    323. Coordinate expression of the PI3-kinase downstream effectors serum and glucocorticoid-induced kinase (SGK-1) and Akt-1 in human breast cancer. (PubMed id 16246546)9 Sahoo S....Conzen S.D. (Eur. J. Cancer 2005)
    324. Regulation of GDF-8 signaling by the p38 MAPK. (PubMed id 15567067)9 Philip B....Gao Y. (Cell. Signal. 2005)
    325. p38 mitogen-activated protein kinase downregulates endothelial progenitor cells. (PubMed id 15753227)9 Seeger F.H....Dimmeler S. (Circulation 2005)
    326. PAK1 regulates myosin II-B phosphorylation, filament assembly, localization and cell chemotaxis. (PubMed id 15993754)9 Even-Faitelson L....Ravid S. (Cell. Signal. 2005)
    327. Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells. (PubMed id 15217905)9 Su J.L....Kuo M.L. (Carcinogenesis 2005)
    328. The cytokine IL-1beta activates IFN response factor 3 in human fetal astrocytes in culture. (PubMed id 15749911)9 Rivieccio M.A....Brosnan C.F. (J. Immunol. 2005)
    329. Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease. (PubMed id 15635602)9 Webber K.M....Zhu X. (J. Neurosci. Res. 2005)
    330. A single pair of acidic residues in the kinase major groove mediates strong substrate preference for P-2 or P-5 arginine in the AGC, CAMK, and STE kinase families. (PubMed id 16131491)9 Zhu G....Shaw S. (J. Biol. Chem. 2005)
    331. Transforming growth factor (TGF)-beta-activated kinase 1 mimics and mediates TGF-beta-induced stimulation of type II collagen synthesis in chondrocytes independent of Col2a1 transcription and Smad3 signaling. (PubMed id 15743758)9 Qiao B....Benya P.D. (J. Biol. Chem. 2005)
    332. Pak1 phosphorylation of snail, a master regulator of epithelial-to- mesenchyme transition, modulates snail's subcellular localization and functions. (PubMed id 15833848)9 Yang Z.... Kumar R. (Cancer Res. 2005)
    333. Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. (PubMed id 15983381)9 Junn E....Mouradian M.M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    334. Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship. (PubMed id 16221215)9 von Wowern F....Melander O. (Kidney Int. 2005)
    335. Transforming growth factor beta-activated kinase 1 is a key mediator of ovine follicle-stimulating hormone beta-subunit expression. (PubMed id 16081641)9 Safwat N....Miller W.L. (Endocrinology 2005)
    336. Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. (PubMed id 16079129)9 Petit A....Tandon A. (J. Biol. Chem. 2005)
    337. Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. (PubMed id 15713627)9 Parsons M....Ng T. (Mol. Cell. Biol. 2005)
    338. Angiotensin II promotes leptin production in cultured human fat cells by an ERK1/2-dependent pathway. (PubMed id 15976138)9 Skurk T....Hauner H. (Obes. Res. 2005)
    339. Changes in retinal gene expression in proliferative vitreoretinopathy: glial cell expression of HB-EGF. (PubMed id 15988409)9 Hollborn M....Bringmann A. (Mol. Vis. 2005)
    340. TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation. (PubMed id 15814732)9 Liu-Bryan R....Terkeltaub R. (J. Immunol. 2005)
    341. X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1). (PubMed id 16157589)9 Kaur S....Arsura M. (J. Biol. Chem. 2005)
    342. Spatiotemporal regulation of the Pak1 kinase. (PubMed id 16042564)9 Parrini M.C....de Gunzburg J. (Biochem. Soc. Trans. 2005)
    343. TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd. (PubMed id 16251197)9 Morlon A....Smahi A. (Hum. Mol. Genet. 2005)
    344. Modulation of the p38 MAPK (mitogen-activated protein kinase) pathway through Bcr/Abl: implications in the cellular response to Ara-C. (PubMed id 15540985)9 SA!nchez-ArAcvalo Lobo V.J....SA!nchez-Prieto R. (Biochem. J. 2005)
    345. Identification of ASK1, MKK4, JNK, c-Jun, and caspase-3 as a signaling cascade involved in cadmium-induced neuronal cell apoptosis. (PubMed id 15670787)9 Kim S.D....Jo S.A. (Biochem. Biophys. Res. Commun. 2005)
    346. Depressed tumor necrosis factor alpha and interleukin-12p40 production by peripheral blood mononuclear cells of gastric cancer patients: association with IL-1R-associated kinase-1 protein expression and disease stage. (PubMed id 15523691)9 Siedlar M....Zembala M. (Int. J. Cancer 2005)
    347. Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells. (PubMed id 15178330)9 Balasenthil S....Kumar R. (FEBS Lett. 2004)
    348. S-nitrosation of thioredoxin in the nitrogen monoxide/superoxide system activates apoptosis signal-regulating kinase 1. (PubMed id 15246877)9 Yasinska I.M.... Sumbayev V.V. (Arch. Biochem. Biophys. 2004)
    349. Role of E2F and ERK1/2 in STI571-mediated smooth muscle cell growth arrest and cyclin A transcriptional repression. (PubMed id 15094364)9 Sanz-GonzA!lez S.M....AndrAcs V. (Biochem. Biophys. Res. Commun. 2004)
    350. Inactivation of ERK accelerates erythroid differentiation of K562 cells induced by herbimycin A and STI571 while activation of MEK1 interferes with it. (PubMed id 15030167)9 Kawano T....Yamada H. (Mol. Cell. Biochem. 2004)
    351. Membrane type 1 matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-related kinase activation and cell migration. (PubMed id 14871836)9 Takino T....Sato H. (Cancer Res. 2004)
    352. p90 ribosomal S6 kinase 2 is associated with and dephosphorylated by protein phosphatase 2Cdelta. (PubMed id 15206906)9 Doehn U....Jensen C.J. (Biochem. J. 2004)
    353. p21-activated kinase 1: an emerging therapeutic target. (PubMed id 15164874)9 Vadlamudi R.K. and Kumar R. (Cancer Treat. Res. 2004)
    354. Amidine analogue of chlorambucil is a stronger inhibitor of protein and DNA synthesis in breast cancer MCF-7 cells than is the parent drug. (PubMed id 15178351)9 Sienkiewicz P....PaA8ka J. (Eur. J. Pharmacol. 2004)
    355. The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein. (PubMed id 15274926)9 Smith K.J....Reith A. (Structure 2004)
    356. Mechanisms of mineralocorticoid action: determinants of receptor specificity and actions of regulated gene products. (PubMed id 15109612)9 Bhargava A. and Pearce D. (Trends Endocrinol. Metab. 2004)
    357. p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate. (PubMed id 14749719)9 Vadlamudi R.K....Kumar R. (EMBO Rep. 2004)
    358. Co-aggregation of FcgammaRII with FcepsilonRI on human mast cells inhibits antigen-induced secretion and involves SHIP-Grb2-Dok complexes. (PubMed id 15151996)9 Kepley C.L....Saxon A. (J. Biol. Chem. 2004)
    359. Signalling pathways for insulin-like growth factor type 1-mediated expression of uncoupling protein 3. (PubMed id 14690534)9 Gustafsson H....Forsby A. (J. Neurochem. 2004)
    360. Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain. (PubMed id 15139849)9 Cross J.V. and Templeton D.J. (Biochem. J. 2004)
    361. Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. (PubMed id 15193260)9 Vadlamudi R.K.... Kumar R. (Cancer Cell 2004)
    362. Pak-1 expression increases with progression of colorectal carcinomas to metastasis. (PubMed id 15161701)9 Carter J.H....Graff J.R. (Clin. Cancer Res. 2004)
    363. Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) gamma2 gene expression in brown adipocytes: intracellular signalling and effects on PPARgamma2 and PPARgamma1 protein levels. (PubMed id 15193150)9 Lindgren E.M....Nedergaard J. (Biochem. J. 2004)
    364. Identification and cloning of genes displaying elevated expression as a consequence of metastatic progression in human melanoma cells by rapid subtraction hybridization. (PubMed id 15563845)9 Boukerche H....Fisher P.B. (Gene 2004)
    365. Human immunodeficiency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant production. (PubMed id 14694110)9 Wu R.F....Terada L.S. (J. Virol. 2004)
    366. Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. (PubMed id 14764725)9 Asehnoune K....Abraham E. (J. Immunol. 2004)
    367. Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism. (PubMed id 15208259)9 Verdier-Sevrain S....Gilchrest B.A. (FASEB J. 2004)
    368. The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells. (PubMed id 14760089)9 Yang Z....Kumar R. (Clin. Cancer Res. 2004)
    369. TGF-beta1 and angiotensin networking in cardiac remodeling. (PubMed id 15276467)9 Rosenkranz S. (Cardiovasc. Res. 2004)
    370. The biochemical response of the heart to hypertension and exercise. (PubMed id 15501680)9 Wakatsuki T....Elson E.L. (Trends Biochem. Sci. 2004)
    371. Protein kinase Czeta mediated Raf-1/extracellular-regulated kinase activation by daunorubicin. (PubMed id 12406911)9 Mas V.M....Laurent G. (Blood 2003)
    372. Vitamin D growth inhibition of breast cancer cells: gene expression patterns assessed by cDNA microarray. (PubMed id 12889598)9 Swami S....Feldman D. (Breast Cancer Res. Treat. 2003)
    373. Human neutrophils utilize a Rac/Cdc42-dependent MAPK pathway to direct intracellular granule mobilization toward ingested microbial pathogens. (PubMed id 12511425)9 Zhong B....Wei S. (Blood 2003)
    374. Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein. (PubMed id 12874243)9 Jensen L.E. and Whitehead A.S. (J. Immunol. 2003)
    375. TGFbeta1 activates c-Jun and Erk1 via alphaVbeta6 integrin. (PubMed id 14572313)9 Luettich K. and Schmidt C. (Mol. Cancer 2003)
    376. TGF-beta1 suppresses apoptosis via differential regulation of MAP kinases and ceramide production. (PubMed id 12728250)9 Chen H.H....Song J.G. (Cell Death Differ. 2003)
    377. Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. (PubMed id 14580336)9 Kissil J.L....Jacks T. (Mol. Cell 2003)
    378. Ets2 and protein kinase C epsilon are important regulators of parathyroid hormone-related protein expression in MCF-7 breast cancer cells. (PubMed id 12628005)9 Lindemann R.K....Dittmer J. (Biochem. J. 2003)
    379. Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise. (PubMed id 12527721)9 Yu M....Zierath J.R. (J. Physiol. (Lond.) 2003)
    380. Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. (PubMed id 12941695)9 MA1ller J....Morrison D.K. (EMBO J. 2003)
    381. Tumor necrosis factor-alpha induces interleukin-6 production via extracellular-regulated kinase 1 activation in breast cancer cells. (PubMed id 12889600)9 Suarez-Cuervo C....Selander K.S. (Breast Cancer Res. Treat. 2003)
    382. Phorbol ester-induced migration of HepG2 cells is accompanied by intensive stress fibre formation, enhanced integrin expression and transient down-regulation of p21-activated kinase 1. (PubMed id 12531429)9 GujdA!r A....FaragA^ A. (Cell. Signal. 2003)
    383. EGF activates an inducible survival response via the RAS-&gt; Erk-1/2 pathway to counteract interferon-alpha-mediated apoptosis in epidermoid cancer cells. (PubMed id 12700650)9 Caraglia M....Abbruzzese A. (Cell Death Differ. 2003)
    384. Functional inactivation of a transcriptional corepressor by a signaling kinase. (PubMed id 12872159)9 Barnes C.J....Kumar R. (Nat. Struct. Biol. 2003)
    385. Association of a haplotype (196Phe/532Ser) in the interleukin-1-receptor-associated kinase (IRAK1) gene with low radial bone mineral density in two independent populations. (PubMed id 12619925)9 Ishida R....Orimo H. (J. Bone Miner. Res. 2003)
    386. Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition. (PubMed id 12551923)9 Tran N.H. and Frost J.A. (J. Biol. Chem. 2003)
    387. Amphiregulin is a potent mitogen for the vascular smooth muscle cell line, A7r5. (PubMed id 12589827)9 Kato M....Miyamori I. (Biochem. Biophys. Res. Commun. 2003)
    388. CBF1 controls the retinotectal topographical map along the anteroposterior axis through multiple mechanisms. (PubMed id 12954716)9 Takahashi H....Noda M. (Development 2003)
    389. The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization. (PubMed id 12829723)9 Hashimoto Y....Nishimoto I. (J. Pharmacol. Exp. Ther. 2003)
    390. Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells. (PubMed id 12560069)9 Mazumdar A. and Kumar R. (FEBS Lett. 2003)
    391. Hepatitis C virus proteins do not directly trigger fibrogenic events in cultured human liver myofibroblasts. (PubMed id 14633175)9 Tan K....Rosenbaum J. (J. Viral Hepat. 2003)
    392. Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways. (PubMed id 14575865)9 Menard R.E. and Mattingly R.R. (Cell. Signal. 2003)
    393. E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions. (PubMed id 12649084)9 Yoshida M....Kimura A. (Arterioscler. Thromb. Vasc. Biol. 2003)
    394. Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643. (PubMed id 12729718)9 Vanden Heuvel J.P....Taylor M.J. (Toxicol. Appl. Pharmacol. 2003)
    395. Angiotensin II activates extracellular signal regulated kinases via protein kinase C and epidermal growth factor receptor in breast cancer cells. (PubMed id 12811831)9 Greco S....Marsigliante S. (J. Cell. Physiol. 2003)
    396. Concerted roles of SGK1 and the Na+/H+ exchanger regulatory factor 2 (NHERF2) in regulation of NHE3. (PubMed id 12649600)9 Yun C.C. (Cell. Physiol. Biochem. 2003)
    397. Suppression of epidermal growth factor receptor, mitogen-activated protein kinase, and Pak1 pathways and invasiveness of human cutaneous squamous cancer cells by the tyrosine kinase inhibitor ZD1839 (Iressa). (PubMed id 12700278)9 Barnes C.J....Kumar R. (Mol. Cancer Ther. 2003)
    398. Activation of NF-kappa B in virus-infected macrophages is dependent on mitochondrial oxidative stress and intracellular calcium: downstream involvement of the kinases TGF-beta-activated kinase 1, mitogen-activated kinase/extracellular signal-regulated kinase kinase 1, and I kappa B kinase. (PubMed id 12794154)9 Mogensen T.H....Paludan S.R. (J. Immunol. 2003)
    399. Non-specific effects of the MEK inhibitors PD098,059 and U0126 on glutamate release from hippocampal synaptosomes. (PubMed id 11750912)9 Pereira D.B....Duarte C.B. (Neuropharmacology 2002)
    400. Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. (PubMed id 12391239)9 Medvedev A.E....Vogel S.N. (J. Immunol. 2002)
    401. Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling. (PubMed id 12220225)9 Paling N.R. and Welham M.J. (Biochem. J. 2002)
    402. CD40-mediated tumor necrosis factor receptor-associated factor 3 signaling upregulates IL-4-induced germline Cepsilon transcription in a human B cell line. (PubMed id 12220533)9 Basaki Y....Yanagihara Y. (Arch. Biochem. Biophys. 2002)
    403. Inhibition of the potassium current IK(SO), in cerebellar granule cells, by the inhibitors of MEK1 activation, PD 98059 and U 0126. (PubMed id 11804618)9 Boyd D.F. and Mathie A. (Neuropharmacology 2002)
    404. Proteolytic inhibition of Salmonella enterica serovar typhimurium-induced activation of the mitogen-activated protein kinases ERK and JNK in cultured human intestinal cells. (PubMed id 11748167)9 Mynott T.L....Prathalingam S.R. (Infect. Immun. 2002)
    405. Suppression of Rac activity induces apoptosis of human glioma cells but not normal human astrocytes. (PubMed id 11929835)9 Senger D.L....Kaplan D.R. (Cancer Res. 2002)
    406. Molecular interpretation of ERK signal duration by immediate early gene products. (PubMed id 12134156)9 Murphy L.O.... Blenis J. (Nat. Cell Biol. 2002)
    407. Transforming growth factor-beta1 transcriptionally activates CD34 and prevents induced differentiation of TF-1 cells in the absence of any cell-cycle effects. (PubMed id 11840268)9 Marone M....Pierelli L. (Leukemia 2002)
    408. Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells. (PubMed id 11903060)9 Tao L....August A. (Biochem. J. 2002)
    409. Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray. (PubMed id 12219026)9 Weldon C.B....Burow M.E. (Surgery 2002)
    410. P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration. (PubMed id 12356872)9 Zhang H.... Stromblad S. (J. Cell Biol. 2002)
    411. Pak1 is involved in dendrite initiation as a downstream effector of Rac1 in cortical neurons. (PubMed id 12213441)9 Hayashi K....Mikoshiba K. (Mol. Cell. Neurosci. 2002)
    412. RISK-1: a novel MAPK homologue in axoplasm that is activated and retrogradely transported after nerve injury. (PubMed id 11257614)9 Sung Y.J....Ambron R.T. (J. Neurobiol. 2001)
    413. P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase. (PubMed id 11549724)9 Panenka W....MacVicar B.A. (J. Neurosci. 2001)
    414. C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. (PubMed id 11741534)9 MA1ller J....Morrison D.K. (Mol. Cell 2001)
    415. Bradykinin induced mitogenesis of androgen independent prostate cancer cells. (PubMed id 11371939)9 Barki-Harrington L. and Daaka Y. (J. Urol. 2001)
    416. The extracellular signal-regulated protein kinases Erk1/Erk2 stimulate expression and biological activity of the transcriptional regulator Egr-1. (PubMed id 11530939)9 Kaufmann K....Thiel G. (Biol. Chem. 2001)
    417. IRAK and TAK1 are required for IL-18-mediated signaling. (PubMed id 11745395)9 Wald D....Li X. (Eur. J. Immunol. 2001)
    418. Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1. (PubMed id 11397816)9 Sasaki Y. and Sugamura K. (J. Biol. Chem. 2001)
    419. Vitamin E analog modulates UVB-induced signaling pathway activation and enhances cell survival. (PubMed id 11182298)9 Peus D....Pittelkow M.R. (amp 2001)
    420. Phosphorylation of p38 mitogen-activated protein kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cells. (PubMed id 11375350)9 Nakagami H....Ogihara T. (Diabetes 2001)
    421. Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle. (PubMed id 11579175)9 Yu M....Zierath J.R. (J. Physiol. (Lond.) 2001)
    422. An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein. (PubMed id 11053419)9 Huai J. and Drescher U. (J. Biol. Chem. 2001)
    423. Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells. (PubMed id 11382770)9 Bagheri-Yarmand R....Kumar R. (J. Biol. Chem. 2001)
    424. Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1. (PubMed id 11278764)9 Mikosz C.A....Conzen S.D. (J. Biol. Chem. 2001)
    425. Regulation and composition of activator protein 1 (AP-1) transcription factors controlling collagenase and c-Jun promoter activities. (PubMed id 11736649)9 SteinmA1ller L....Thiel G. (Biochem. J. 2001)
    426. The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1. (PubMed id 11416155)9 Zou X....Kiyokawa H. (Mol. Cell. Biol. 2001)
    427. A dominant negative inhibitor of the Egr family of transcription regulatory factors suppresses cerebellar granule cell apoptosis by blocking c-Jun activation. (PubMed id 11487612)9 Levkovitz Y. and Baraban J.M. (J. Neurosci. 2001)
    428. Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin. (PubMed id 11594781)9 Gunaje J.J. and Bhat G.J. (Biochem. Biophys. Res. Commun. 2001)
    429. LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505. (PubMed id 11171090)9 Amano T....Mizuno K. (Biochem. J. 2001)
    430. The coronary endothelium-derived hyperpolarizing factor (EDHF) stimulates multiple signalling pathways and proliferation in vascular cells. (PubMed id 11510882)9 Fleming I....Busse R. (Pflugers Arch. 2001)
    431. Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. (PubMed id 11096076)9 Ko Y.G....Kim S. (J. Biol. Chem. 2001)
    432. IRAK1b, a novel alternative splice variant of interleukin-1 receptor- associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability. (PubMed id 11397809)9 Jensen L.E. and Whitehead A.S. (J. Biol. Chem. 2001)
    433. Mechanical strain and estrogen activate estrogen receptor alpha in bone cells. (PubMed id 11393781)9 Jessop H.L....Lanyon L.E. (J. Bone Miner. Res. 2001)
    434. Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway. (PubMed id 11087735)9 Linseman D.A....Fisher S.K. (J. Biol. Chem. 2001)
    435. p21-activated kinase-1 (PAK1) inhibition of the human scavenger receptor class B, type I promoter in macrophages is independent of PAK1 kinase activity, but requires the GTPase-binding domain. (PubMed id 11585816)9 Hullinger T.G....Karathanasis S.K. (J. Biol. Chem. 2001)
    436. Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene. (PubMed id 11564864)9 Yoshii S....Sugimura H. (Mol. Cell. Biol. 2001)
    437. UVB-induced epidermal growth factor receptor phosphorylation is critical for downstream signaling and keratinocyte survival. (PubMed id 10911738)9 Peus D....Pittelkow M.R. (Photochem. Photobiol. 2000)
    438. Eph receptors and ephrin expression in cranial motor neurons and the branchial arches of the chick embryo. (PubMed id 10673322)9 KA1ry P....Guthrie S. (Mol. Cell. Neurosci. 2000)
    439. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. (PubMed id 11062502)9 Jiang K....Djeu J.Y. (Nat. Immunol. 2000)
    440. Regulation of macropinocytosis by p21-activated kinase-1. (PubMed id 11029040)9 Dharmawardhane S....Bokoch G.M. (Mol. Biol. Cell 2000)
    441. Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. (PubMed id 10945974)9 Vadlamudi R.K....Kumar R. (J. Biol. Chem. 2000)
    442. Requirement of hydrogen peroxide generation in TGF-beta 1 signal transduction in human lung fibroblast cells: involvement of hydrogen peroxide and Ca2+ in TGF-beta 1-induced IL-6 expression. (PubMed id 10925306)9 Junn E....Choi I. (J. Immunol. 2000)
    443. Dual control of muscle cell survival by distinct growth factor-regulated signaling pathways. (PubMed id 10757809)9 Lawlor M.A....Rotwein P. (Mol. Cell. Biol. 2000)
    444. Peroxynitrite modulates the activation of p38 and extracellular regulated kinases in PC12 cells. (PubMed id 10775424)9 Jope R.S....Song L. (Arch. Biochem. Biophys. 2000)
    445. p21-activated kinase (PAK1) is phosphorylated and activated by 3- phosphoinositide-dependent kinase-1 (PDK1). (PubMed id 10995762)9 King C.C.... Bokoch G.M. (J. Biol. Chem. 2000)
    446. Terminal complement complexes concomitantly stimulate proliferation and rescue of Schwann cells from apoptosis. (PubMed id 10719360)9 Dashiell S.M....Koski C.L. (Glia 2000)
    447. Salivary cellular signaling and gene regulation. (PubMed id 11842928)9 Wen X....Ann D.K. (Adv. Dent. Res. 2000)
    448. Protein kinase C regulates integrin-induced activation of the extracellular regulated kinase pathway upstream of Shc. (PubMed id 10187852)9 Miranti C.K....Brugge J.S. (J. Biol. Chem. 1999)
    449. Activation of mitogen-activated protein kinase associated with prostate cancer progression. (PubMed id 9927031)9 Gioeli D....Weber M.J. (Cancer Res. 1999)
    450. Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade. (PubMed id 10224067)9 Zhou G....Tan T.H. (J. Biol. Chem. 1999)
    451. Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils. (PubMed id 10496324)9 Dharmawardhane S....Bokoch G.M. (J. Leukoc. Biol. 1999)
    452. Two distinct signaling pathways downstream of Janus kinase 2 play redundant roles for antiapoptotic activity of granulocyte-macrophage colony-stimulating factor. (PubMed id 10564283)9 Liu R....Watanabe S. (Mol. Biol. Cell 1999)
    453. Inhibition of myosin light chain kinase by p21-activated kinase. (PubMed id 10092231)9 Sanders L.C....de Lanerolle P. (Science 1999)
    454. A cluster of five cell wall-associated receptor kinase genes, Wak1-5, are expressed in specific organs of Arabidopsis. (PubMed id 10380805)9 He Z.H....Kohorn B.D. (Plant Mol. Biol. 1999)
    455. Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation. (PubMed id 9915804)9 Abbott D.W. and Holt J.T. (J. Biol. Chem. 1999)
    456. MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells. (PubMed id 10085121)9 Brown J.D....Topper J.N. (J. Biol. Chem. 1999)
    457. p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. (PubMed id 10330410)9 Sells M.A....Chernoff J. (J. Cell Biol. 1999)
    458. Effects of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on human small airway epithelial cells and the protective effects of myo-inositol. (PubMed id 9934861)9 Jyonouchi H....Hecht S.S. (Carcinogenesis 1999)
    459. alpha-thrombin inhibits interleukin-6-induced Stat3 signaling and gp130 gene expression in primary cultures of human lung fibroblasts. (PubMed id 10080949)9 Bhat G.J....Idell S. (Biochem. Biophys. Res. Commun. 1999)
    460. ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling. (PubMed id 10085140)9 Sano Y....Ishii S. (J. Biol. Chem. 1999)
    461. Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner. (PubMed id 10391889)9 Rolli M....Neininger A. (J. Biol. Chem. 1999)
    462. H2O2 is required for UVB-induced EGF receptor and downstream signaling pathway activation. (PubMed id 10641711)9 Peus D....Pittelkow M.R. (amp 1999)
    463. Distinct mechanisms target stress and extracellular signal-activated kinase 1 and Jun N-terminal kinase during infection of macrophages with Salmonella. (PubMed id 10528195)9 Procyk K.J....Baccarini M. (J. Immunol. 1999)
    464. An early developmental role for eph-ephrin interaction during vertebrate gastrulation. (PubMed id 10381569)9 Oates A.C....Boyd A.W. (Mech. Dev. 1999)
    465. A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation. (PubMed id 9799732)9 Robinson M.J....Cobb M.H. (Curr. Biol. 1998)
    466. TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism. (PubMed id 9480845)9 Sakurai H.... Sugita T. (Biochem. Biophys. Res. Commun. 1998)
    467. Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. (PubMed id 9774445)9 Adam L....Kumar R. (J. Biol. Chem. 1998)
    468. Feedback regulation of Raf-1 and mitogen-activated protein kinase (MAP) kinase kinases 1 and 2 by MAP kinase phosphatase-1 (MKP-1). (PubMed id 9430728)9 Shapiro P.S. and Ahn N.G. (J. Biol. Chem. 1998)
    469. Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production. (PubMed id 9510155)9 Dumont F.J....Camacho R. (J. Immunol. 1998)
    470. Activation of stress-activated protein kinase/c-Jun N-terminal kinase, but not NF-kappaB, by the tumor necrosis factor (TNF) receptor 1 through a TNF receptor-associated factor 2- and germinal center kinase related-dependent pathway. (PubMed id 9405407)9 Shi C.S. and Kehrl J.H. (J. Biol. Chem. 1997)
    471. Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling. (PubMed id 8999807)9 Atfi A....Gespach C. (J. Biol. Chem. 1997)
    472. Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains. (PubMed id 9268338)9 Zhang B....Zheng Y. (J. Biol. Chem. 1997)
    473. Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells. (PubMed id 9298982)9 Dharmawardhane S....Bokoch G.M. (J. Cell Biol. 1997)

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHA3 Predesigned siRNA for gene silencing in human, mouse, rat EPHA3
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA3
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