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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

EPHA3 Gene

protein-coding   GIFtS: 69
GCID: GC03P089239

EPH Receptor A3

(Previous name: EphA3)
(Previous symbols: ETK, ETK1, TYRO4)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

EPH Receptor A31 2     EphA31
ETK11 2 3 5     HEK42
ETK1 2 3     Ephrin Type-A Receptor 32
TYRO41 2 3     Human Embryo Kinase 12
HEK2 3 5     TYRO4 Protein Tyrosine Kinase2
Eph-Like Tyrosine Kinase 12 3     hEK43
Tyrosine-Protein Kinase Receptor ETK12 3     Human Embryo Kinase3
EK42 3     Tyrosine-Protein Kinase TYRO43
EPH-Like Kinase 42 3     EC 2.7.108
EC 8     

External Ids:    HGNC: 33871   Entrez Gene: 20422   Ensembl: ENSG000000445247   OMIM: 1796115   UniProtKB: P293203   

Export aliases for EPHA3 gene to outside databases

Previous GC identifers: GC03P089525 GC03P092010 GC03P089036 GC03P089077

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EPHA3 Gene:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related
receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors
in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich
domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity
of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene
encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for EPHA3 Gene: 
EPHA3 (EPH receptor A3) is a protein-coding gene. Diseases associated with EPHA3 include pleomorphic rhabdomyosarcoma, and ampulla of vater carcinoma, and among its related super-pathways are Ras Pathway and MAPK Signaling. GO annotations related to this gene include GPI-linked ephrin receptor activity and ATP binding. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320
Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds
preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell
migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the
atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the
retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons
during neuromuscular circuit development

Gene Wiki entry for EPHA3 (EPH receptor A3) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022459.15  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EPHA3 gene promoter:
         AP-1   HTF   ATF-2   IRF-7A   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPHA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for EPHA3

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHA3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p11.2   Ensembl cytogenetic band:  3p11.1   HGNC cytogenetic band: 3p11.2

EPHA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHA3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P089239:  view genomic region     (about GC identifiers)

89,156,674 bp from pter      End:
89,531,284 bp from pter
374,611 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320 (See protein sequence)
Recommended Name: Ephrin type-A receptor 3 precursor  
Size: 983 amino acids; 110131 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a
receptor dimer. Oligomerization is probably required to induce biological responses. Forms a ternary
EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the
EFNA5-EPHA3 complex internalization and function. Interacts with NCK1 (via SH2 domain); mediates EFNA5-EPHA3
signaling (By similarity). Interacts (phosphorylated) with PTPN1; dephosphorylates EPHA3 and may regulate its
trafficking and function. Interacts (phosphorylated) with CRK; mediates EFNA5-EPHA3 signaling through RHOA GTPase
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
6/21 PDB 3D structures from and Proteopedia for EPHA3 (see all 21):
2GSF (3D)        2QO2 (3D)        2QO7 (3D)        2QO9 (3D)        2QOB (3D)        2QOC (3D)    
Secondary accessions: Q9H2V3 Q9H2V4
Alternative splicing: 2 isoforms:  P29320-1   P29320-2   

Explore the universe of human proteins at neXtProt for EPHA3: NX_P29320

Explore proteomics data for EPHA3 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1.
    Dephosphorylated by PTPN1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P29320

  • 4/62 DME Specific Peptides for EPHA3 (P29320) (see all 62)

    EPHA3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EPHA3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_005224.2  NP_872585.1  

    ENSEMBL proteins: 
     ENSP00000337451   ENSP00000399926   ENSP00000419190  

    Human Recombinant Protein Products for EPHA3: 
    EMD Millipore Purified and/or Recombinant EPHA3 Protein
    R&D Systems Recombinant & Natural Proteins for EPHA3
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for EPHA3
    OriGene Protein Over-expression Lysate for EPHA3
    OriGene MassSpec for EPHA3 
    OriGene Custom Protein Services for EPHA3
    GenScript Purified and Recombinant Proteins for EPHA3
    Novus Biologicals EPHA3 Proteins
    Novus Biologicals EPHA3 Lysates
    Sino Biological Recombinant Protein for EPHA3
    Sino Biological Cell Lysate for EPHA3 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EPHA3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005769early endosome IDA--
    GO:0005887integral to plasma membrane IDA11870224

    EPHA3 for ontologies           About GeneDecksing

    EPHA3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for EPHA3
    Cell Signaling Technology (CST) Antibodies for EPHA3 
    OriGene Antibodies for EPHA3
    OriGene Custom Antibody Services for EPHA3
    GenScript Custom Superior Antibodies Services for EPHA3
    Novus Biologicals EPHA3 Antibodies
    Abcam antibodies for EPHA3
    Cloud-Clone Corp. Antibodies for EPHA3 
    ThermoFisher Antibodies for EPHA3
    LSBio Antibodies in human, mouse, rat for EPHA3 

    Assay Products for EPHA3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EPHA3
    R&D Systems Proteome Profiler Antibody Arrays for EPHA3
    GenScript EPHA3-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EPHA3 
    Cloud-Clone Corp. CLIAs for EPHA3

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor A3 
    Ephrin receptor family
    Ephrin receptor family

    5/16 InterPro protein domains (see all 16):
     IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
     IPR017441 Protein_kinase_ATP_BS
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR011510 SAM_2

    Graphical View of Domain Structure for InterPro Entry P29320

    ProtoNet protein and cluster: P29320

    5/6 Blocks protein domains (see all 6):
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase

    UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain

    EPHA3 for domains           About GeneDecksing

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHA3_HUMAN, P29320
    Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds
    preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell
    migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the
    atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the
    retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons
    during neuromuscular circuit development
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for EPHA3:
    EPH-related tyrosine kinase receptor binding ephrins A,expressed in projecting neurons and their target
    fields,involved in short-range contact-mediated axonal guidance,expressed by some pre-B and T cell lines,not
    detectable on normal adult human tissues

         Enzyme Numbers (IUBMB): EC 2 EC 2.7.102

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0005003ephrin receptor activity ----
    GO:0005004GPI-linked ephrin receptor activity IDA11870224
    GO:0005515protein binding IPI11870224
    EPHA3 for ontologies           About GeneDecksing

         1 GenomeRNAi human phenotype for EPHA3:
     Decreased substrate adherent c 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Epha3):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  liver/biliary system  mortality/aging 
     respiratory system 

    EPHA3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Epha3tm1Abn for EPHA3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EPHA3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EPHA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPHA3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPHA3 

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPHA3
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate EPHA3 (see all 80):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-548j hsa-miR-3607-3p hsa-miR-3653 hsa-miR-550a* hsa-miR-208b hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidEPHA3 3' UTR sequence
    Inhib. RNA
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EPHA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHA3

    Gene Editing
    DNA2.0 Custom Protein Engineering Service for EPHA3
    Sirion Biotech Customized adenovirus for overexpression of EPHA3

    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for EPHA3 (see all 14)
    OriGene ORF clones in mouse, rat for EPHA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): EPHA3 (NM_005233)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA3
    Sirion Biotech Customized lentivirus for stable overexpression of EPHA3 
                         Customized lentivirus expression plasmids for stable overexpression of EPHA3 

    Cell Line
    GenScript Custom overexpressing Cell Line Services for EPHA3
    Search LifeMap BioReagents cell lines for EPHA3
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA3

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EPHA3 About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    CDC42 Pathway0.41
    Actin Nucleation and Branching0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for EPHA3
        Neurophysiological process Receptor-mediated axon growth repulsion
    Cell adhesion Ephrins signaling
    G-protein signaling RhoA regulation pathway

    5/32 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPHA3 (see all 32)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    P2Y Receptor Signaling

    1 Cell Signaling Technology (CST) Pathway for EPHA3
        Tyrosine Kinases / Adaptors

    3 GeneGo (Thomson Reuters) Pathways for EPHA3
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    2 BioSystems Pathways for EPHA3
        EPHA forward signaling
    EphrinA-EPHA pathway

    1         Kegg Pathway  (Kegg details for EPHA3):
        Axon guidance

    EPHA3 for pathways           About GeneDecksing


        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EPHA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for EPHA3 (P293202, 3 ENSP000003374514) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUFY1Q96T512, 3, ENSP000003770944MINT-8032251 MINT-8035980 I2D: score=2 STRING: ENSP00000377094
    CDKN2AP427713, ENSP000003551534I2D: score=1 I2D: score=1 STRING: ENSP00000355153
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    EFNA1P208273, ENSP000003573924I2D: score=2 STRING: ENSP00000357392
    EFNA5P528033, ENSP000003287774I2D: score=2 STRING: ENSP00000328777
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006915apoptotic process ----
    GO:0007155cell adhesion IEA--
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----
    GO:0010717regulation of epithelial to mesenchymal transition ISS--

    EPHA3 for ontologies           About GeneDecksing

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EPHA3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EPHA3

    2 HMDB Compounds for EPHA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    10/48 Novoseek inferred chemical compound relationships for EPHA3 gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-1 73.8 4 11745395 (1), 17052891 (1), 17932218 (1), 19531477 (1)
    threonine 65.1 24 16641196 (1), 19966577 (1), 20416281 (1), 9405407 (1) (see all 23)
    pd 98,059 59.7 10 18778461 (1), 10925306 (1), 12628005 (1), 14690534 (1) (see all 9)
    tyrosine 57.3 21 1334998 (2), 8188238 (2), 15151996 (1), 18762249 (1) (see all 18)
    serine 55 22 16641196 (1), 19966577 (1), 20416281 (1), 9405407 (1) (see all 22)
    cl 100 52.7 1 15030167 (1)
    sb 203580 50.5 2 18778461 (1), 12589827 (1)
    phosphatidylinositol 48.8 5 14633175 (1), 16322251 (1), 11382770 (1), 12589827 (1) (see all 5)
    phosphoinositide 46.6 8 15468165 (1), 16885398 (1), 16895519 (1), 19920184 (1) (see all 8)
    sp 600125 38.5 3 18778461 (1), 15670787 (1), 12589827 (1)

    Search CenterWatch for drugs/clinical trials and news about EPHA3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EPHA3 gene (2 alternative transcripts): 
    NM_005233.5  NM_182644.2  

    Unigene Cluster for EPHA3:

    EPH receptor A3
    Hs.123642  [show with all ESTs]
    Unigene Representative Sequence: NM_005233
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336596(uc021xbf.1 uc003dqy.3) ENST00000452448(uc003dqx.1)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPHA3
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate EPHA3 (see all 80):
    hsa-miR-411* hsa-miR-323-3p hsa-miR-548j hsa-miR-3607-3p hsa-miR-3653 hsa-miR-550a* hsa-miR-208b hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidEPHA3 3' UTR sequence
    Inhib. RNA
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EPHA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHA3
    OriGene clones in human, mouse for EPHA3 (see all 14)
    OriGene ORF clones in mouse, rat for EPHA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): EPHA3 (NM_005233)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA3
    Sirion Biotech Customized lentivirus for stable overexpression of EPHA3 
                         Customized lentivirus expression plasmids for stable overexpression of EPHA3 
    OriGene qPCR primer pairs and template standards for EPHA3
    OriGene qSTAR qPCR primer pairs in human, mouse for EPHA3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EPHA3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPHA3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHA3

    Additional mRNA sequence: 

    AF213459.1 AF213460.1 AK024352.1 AK291411.1 BC026247.1 BC063282.1 HM437236.1 M83941.1 

    4 DOTS entries:

    DT.97837000  DT.208723  DT.40125530  DT.100662313 

    24/45 AceView cDNA sequences (see all 45):

    NM_182644 BC026247 AF213459 AF213460 AI741389 AI918950 AU137594 AU120483 
    BC063282 AK024352 NM_005233 AL042479 T28603 BE327884 M85652 AU136712 
    BM927323 AI824661 BQ003325 BG033947 M83941 BF194844 AI590014 D81814 

    GeneLoc Exon Structure

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EPHA3 expression in normal human tissues (normalized intensities)      EPHA3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EPHA3 Expression
    About this image

    EPHA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/19 selected tissues (see all 19) fully expand
     Brain (Nervous System)    fully expand to see all 9 entries
             superior temporal gyrus   
     Neural Tube (Nervous System)    fully expand to see all 3 entries
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Zeugopod Epiphyseal End
             Human Calvarial Osteoblasts (HCO)   
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
     Tooth (Integumentary System)    fully expand to see all 2 entries
             visceral organ/oral region/upper jaw   

    See EPHA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EPHA3

    SOURCE GeneReport for Unigene cluster: Hs.123642

    UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320
    Tissue specificity: Widely expressed. Highest level in placenta

        SABiosciences Custom PCR Arrays for EPHA3
    OriGene qPCR primer pairs and template standards for EPHA3
    OriGene qSTAR qPCR primer pairs in human, mouse for EPHA3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EPHA3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPHA3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHA3
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for EPHA3 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Epha31 , 5 Eph receptor A31, 5 88.88(n)1
      16 (36.49 cM)5
    138371  NM_010140.31  NP_034270.11 
    (Gallus gallus)
    Aves EPHA31 EPH receptor A3 81.98(n)
      396402  NM_205430.1  NP_990761.1 
    (Anolis carolinensis)
    Reptilia EPHA36
    Uncharacterized protein
    1 ↔ 1
    (Danio rerio)
    Actinopterygii epha3l6
    eph receptor A3, like
    1 ↔ 1

    ENSEMBL Gene Tree for EPHA3 (if available)
    TreeFam Gene Tree for EPHA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68)
    About This Section
    Paralogs for EPHA3 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHA12  
    EPHB22  EPHA82  EPHA72  EPHA102  EPHB42  
    18/46 SIMAP similar genes for EPHA3 using alignment to 4 protein entries:     EPHA3_HUMAN (see all proteins) (see all similar genes):
    EPHA6    EPHA4    EPHA7    EPHA5    EPHB1    EPHB2 variant protein
    EPHA8    EPHB2    EPHB3    EPHA2    ABL1    FGR
    EPHA10    FES    FYN    EPHB4    SRC    HCK

    EPHA3 for paralogs           About GeneDecksing

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7038 SNPs in EPHA3 are shown (see all 7038)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 3 posSequence#AA
    A lung carcinoma sample4--see VAR_0658322 T M mis40--------
    A lung large cell carcinoma sample4--see VAR_0421262 S Y mis40--------
    A colorectal cancer sample4--see VAR_0360892 D N mis40--------
    A lung adenocarcinoma sample4--see VAR_0421322 G E mis40--------
    A colorectal cancer sample4--see VAR_0360872 N S mis40--------
    A lung squamous cell carcinoma sample4--see VAR_0421282 G L mis40--------
    A colorectal cancer sample4--see VAR_0360862 T K mis40--------
    A colorectal cancer sample4--see VAR_0360882 I L mis40--------
    A lung neuroendocrine carcinoma sample4--see VAR_0421272 S F mis40--------
    A lung carcinoma sample4--see VAR_0658312 T K mis40--------

    HapMap Linkage Disequilibrium report for EPHA3 (89156674 - 89406674 bp, first 250kb of EPHA3)

    Structural Variations
         Database of Genomic Variants (DGV) 10/27 variations for EPHA3 (see all 27):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2490848CNV Deletion19546169
    esv2667696CNV Deletion23128226
    esv2156570CNV Deletion18987734
    nsv435764CNV Deletion17901297
    esv2421597CNV Deletion20811451
    esv2660172CNV Deletion23128226
    esv2663816CNV Deletion23128226
    esv2725646CNV Deletion23290073
    esv2678650CNV Deletion23128226
    esv273850CNV Insertion20981092

    Human Gene Mutation Database (HGMD): EPHA3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing EPHA3
    DNA2.0 Custom Variant and Variant Library Synthesis for EPHA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 179611    OMIM disorders: --

    UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from
    the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with
    progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon
    and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The gene
    represented in this entry may be involved in disease pathogenesis

  • 20/45 diseases for EPHA3 (see all 45):    About MalaCards
    pleomorphic rhabdomyosarcoma    ampulla of vater carcinoma    pseudohypoaldosteronism    familial colorectal cancer
    proliferative vitreoretinopathy    spinal cord injury    rhabdomyosarcoma    parkinson's disease
    neurofibromatosis    prostate cancer, progression of    hepatitis c    cleft palate
    prostate cancer    retinoblastoma    cleft lip    duodenitis
    melanoma    endometriosis    prostatitis    infertility

    EPHA3 for disorders           About GeneDecksing

    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/25 Novoseek inferred disease relationships for EPHA3 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 51 17 16672981 (1), 17579517 (1), 19703660 (1), 17000703 (1) (see all 16)
    parkinsonism 37.2 10 16226715 (1), 19279012 (1), 17084972 (1), 17620882 (1) (see all 10)
    breast cancer 36.5 15 12151336 (2), 18392133 (2), 16322251 (1), 18650427 (1) (see all 13)
    neurodegeneration 33.3 2 19780893 (1), 20012177 (1)
    neurodegenerative diseases 31.3 1 18334630 (1)
    tumors 30.4 23 10498621 (2), 10987298 (2), 15688034 (1), 16778166 (1) (see all 20)
    cancer 27 8 14760089 (1), 17611497 (1), 12560069 (1), 14530270 (1) (see all 8)
    cardiac hypertrophy 11 1 18054038 (1)
    uveal melanoma 7.57 1 16845324 (1)
    necrosis 6.62 3 15523691 (1), 19298660 (1), 12889600 (1)

    Genetic Association Database (GAD): EPHA3
    Human Genome Epidemiology (HuGE) Navigator: EPHA3 (5 documents)

    Export disorders for EPHA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EPHA3 gene, integrated from 9 sources (see all 480) (see top 10):
    (articles sorted by number of sources associating them with EPHA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines. (PubMed id 1311845)1, 2, 3 Wicks I.P....Boyd A.W. (1992)
    2. Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line. (PubMed id 1737782)1, 2, 3 Boyd A.W.... Busmanis I. (1992)
    3. Identification of a tumor-specific shared antigen derived from an Eph receptor and presented to CD4 T cells on HLA class II molecules. (PubMed id 10987298)1, 2, 9 Chiari R....Coulie P.G. (2000)
    4. Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3). (PubMed id 18547520)1, 2, 9 Davis T.L....Dhe-Paganon S. (2008)
    5. Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas. (PubMed id 20838624)1, 2 Corbo V....Scarpa A. (2010)
    6. Genetic mutations associated with cigarette smoking in pancreatic cancer. (PubMed id 19351817)1, 4 Blackford A....Hruban R.H. (2009)
    7. Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. (PubMed id 16941478)1, 2 Wood L.D....Velculescu V.E. (2006)
    8. Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. (PubMed id 16239146)1, 2 Janes P.W....Nikolov D.B. (2005)
    9. Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling. (PubMed id 11870224)1, 2 Lawrenson I.D....Lackmann M. (2002)
    10. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2 (1997)
    11. Low frequency mutation of the Ephrin receptor A3 gene in hepatocellular carcinoma. (PubMed id 19469653)1, 9 Bae H.J....Nam S.W. (2009)
    12. The EphA3 receptor is expressed in a subset of rhabdomyosarcoma cell lines and suppresses cell adhesion and migration. (PubMed id 18814179)1, 9 Clifford N....O'Connor R. (2008)
    13. EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion. (PubMed id 14697337)1, 9 Smith L.M....O'Connor R. (2004)
    14. Localization of a human receptor tyrosine kinase (ETK1) to chromosome region 3p11.2. (PubMed id 8188238)1, 9 Wicks I.P....Sutherland G.R. (1994)
    15. Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3. (PubMed id 15901737)2, 9 Day B....Lackmann M. (2005)
    16. Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases. (PubMed id 19678838)1, 9 Davis T.L....Dhe-Paganon S. (2009)
    17. Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro. (PubMed id 9751130)1, 9 Ciossek T....Drescher U. (1998)
    18. Mechanisms involved in development of retinotectal connections: roles of Eph receptor tyrosine kinases, NMDA receptors and nitric oxide. (PubMed id 9932438)1, 9 Ernst A.F....McLoon S.C. (1998)
    19. EphA3 maintains tumorigenicity and is a therapeutic ta rget in glioblastoma multiforme. (PubMed id 23410976)1 Day B.W....Boyd A.W. (2013)
    20. A high-content cellular senescence screen identifies c andidate tumor suppressors, including EPHA3. (PubMed id 23324396)1 Lahtela J....Verschuren E.W. (2013)
    21. Aberrant expression of EphA3 in gastric carcinoma: cor relation with tumor angiogenesis and survival. (PubMed id 22350700)1 Xi H.Q....Chen L. (2012)
    22. Effects of cancer-associated EPHA3 mutations on lung c ancer. (PubMed id 22829656)1 Zhuang G....Chen J. (2012)
    23. Cancer somatic mutations disrupt functions of the EphA 3 receptor tyrosine kinase through multiple mechanisms. (PubMed id 22242939)1 Lisabeth E.M....Pasquale E.B. (2012)
    24. Genome-wide meta-analyses of nonsyndromic cleft lip wi th or without cleft palate identify six new risk loci. (PubMed id 22863734)1 Ludwig K.U....Nothen M.M. (2012)
    25. Clinicopathological significance and prognostic value of EphA3 and CD133 expression in colorectal carcinoma. (PubMed id 21415057)1 Xi H.Q. and Zhao P. (2011)
    26. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    27. Copy number variations of EphA3 are associated with m ultiple types of hematologic malignancies. (PubMed id 21454190)1 Guan M....Zhang W. (2011)
    28. Sperry versus Hebb: topographic mapping in Isl2/EphA3 mutant mice. (PubMed id 21190559)1 Tsigankov D. and Koulakov A.A. (2010)
    29. Exploring the link between germline and somatic genet ic alterations in breast carcinogenesis. (PubMed id 21124932)1 Bonifaci N....Pujana M.A. (2010)
    30. Multiple tumor-suppressor genes on chromosome 3p cont ribute to head and neck squamous cell carcinoma tumorigenesis. (PubMed id 20657180)1 Lee D.J....Su G.H. (2010)
    31. PTP1B regulates Eph receptor function and trafficking. (PubMed id 21135139)2 Nievergall E.... Lackmann M. (2010)
    32. Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells. (PubMed id 18385452)1 Wimmer-Kleikamp S.H....Lackmann M. (2008)
    33. Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. (PubMed id 18463370)4 Maris J.M....Hakonarson H. (2008)
    34. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    35. Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen. (PubMed id 17910947)1 Yamada S....Miyake J. (2007)
    36. Proteomic analysis of p16ink4a-binding proteins. (PubMed id 17955473)1 Souza-Rodrigues E....Jaumot M. (2007)
    37. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    38. Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)1 Wissing J.... Daub H. (2007)
    39. The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs. (PubMed id 16186805)1 Xie Y.... Qiu Y. (2006)
    40. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    41. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    42. An unappreciated role for RNA surveillance. (PubMed id 14759258)1 Hillman R.T.... Brenner S.E. (2004)
    43. Bi-directional regulation between tyrosine kinase Etk/BMX and tumor suppressor p53 in response to DNA damage. (PubMed id 15355990)1 Jiang T....Qiu Y. (2004)
    44. Interaction between tyrosine kinase Etk and a RUN-domain and FYVE- domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking. (PubMed id 11877430)1 Yang J.... Qiu Y. (2002)
    45. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    46. Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor. (PubMed id 11494128)1 Yu H.H....Pasquale E.B. (2001)
    47. Multiple roles of EPH receptors and ephrins in neural development. (PubMed id 11256076)1 Wilkinson D.G. (2001)
    48. Roles of Eph receptors and ephrins in segmental patterning. (PubMed id 11128993)1 Xu Q....Wilkinson D.G. (2000)
    49. Eph receptors and ephrins: regulators of guidance and assembly. (PubMed id 10730216)1 Wilkinson D.G. (2000)
    50. Eph receptors and ephrins: effectors of morphogenesis. (PubMed id 10207129)1 Holder N. and Klein R. (1999)
    51. Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization. (PubMed id 9685371)1 Lackmann M....Boyd A.W. (1998)
    52. Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region. (PubMed id 9632142)1 Zisch A.H....Pasquale E.B. (1998)
    53. The Eph family receptors and ligands. (PubMed id 9576626)1 Zhou R. (1998)
    54. The ephrins and Eph receptors in neural development. (PubMed id 9530499)1 Flanagan J.G. and Vanderhaeghen P. (1998)
    55. LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain. (PubMed id 9245480)1 Kozlosky C.J....Carpenter M.K. (1997)
    56. Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor. (PubMed id 9195962)1 Lackmann M....Boyd A.W. (1997)
    57. Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases. (PubMed id 8559144)1 Cerretti D.P.... Fletcher R.A. (1995)
    58. Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors. (PubMed id 8070404)1 Beckmann M.P.... Lyman S.D. (1994)
    59. (PubMed id 14660665)2 
    60. Different clinical roles for p21-activated kinase-1 i n primary and recurrent ovarian carcinoma. (PubMed id 18656238)9 Davidson B....Wang T.L. (2008)
    61. EphA3 null mutants do not demonstrate motor axon guidance defects. (PubMed id 14585969)9 Vaidya A....Brown A. (2003)
    62. Cloning and characterization of EphA3 (Hek) gene promoter: DNA methylation regulates expression in hematopoietic tumor cells. (PubMed id 10498621)9 Dottori M....Boyd A.W. (1999)
    63. Concurrent binding of anti-EphA3 antibody and ephrin-A5 amplifies EphA3 signaling and downstream responses: potential as EphA3-specific tumor-targeting reagents. (PubMed id 16061656)9 Vearing C....Lackmann M. (2005)
    64. Regulatory interrelations among topographic molecules CBF1, CBF2 and EphA3 in the developing chick retina. (PubMed id 10545030)9 Yamagata M....Noda M. (1999)
    65. Silencing of EphA3 through a cis interaction with ephrinA5. (PubMed id 16491080)9 Carvalho R.F....Drescher U. (2006)
    66. Upregulation of EphA3 receptor after spinal cord injury. (PubMed id 16083359)9 Irizarry-Ramirez M....Miranda J.D. (2005)
    67. Two homeobox genes define the domain of EphA3 expression in the developing chick retina. (PubMed id 11060230)9 Schulte D. and Cepko C.L. (2000)
    68. Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. (PubMed id 18794135)9 Sherk A.B....McDonnell D.P. (2008)
    69. Rho GTPases and p21-activated kinase in the regulation of proliferation and apoptosis by gastrins. (PubMed id 18565785)9 He H. and Baldwin G.S. (2008)
    70. Potential clinical relevance of Eph receptors and ephrin ligands expressed in prostate carcinoma cell lines. (PubMed id 16516143)9 Fox B.P....Kandpal R.P. (2006)
    71. High EphA3 expressing ophthalmic trigeminal sensory axons are sensitive to ephrin-A5-Fc: implications for lobe specific axon guidance. (PubMed id 16054765)9 Jayasena C.S....Koblar S.A. (2005)
    72. Activation of c-Jun N-terminal kinase in A549 lung carcinoma cells by sodium dichromate: role of dissociation of apoptosis signal regulating kinase-1 from its physiological inhibitor thioredoxin. (PubMed id 15003321)9 Hodges N.J....Chipman J.K. (2004)
    73. Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1. (PubMed id 10748151)9 King C.C....Bokoch G.M. (2000)
    74. Eph receptors and ephrins in the developing chick cerebellum: relationship to sagittal patterning and granule cell migration. (PubMed id 10964955)9 Karam S.D....Bothwell M. (2000)
    75. Constitutive association of TGF-beta-activated kinase 1 with the IkappaB kinase complex in the nucleus and cytoplasm of human neutro phils and its impact on downstream processes. (PubMed id 20200282)9 Ear T....McDonald P.P. (2010)
    76. Increased expression of serum- and glucocorticoid-reg ulated kinase-1 in the duodenal mucosa of children with coeliac disease. (PubMed id 19966577)9 Szebeni B....AratA^ A. (2010)
    77. Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation. (PubMed id 19406912)9 Haudek S.B....Entman M.L. (2009)
    78. [Effect of p21-activated kinase-1 on the invasiveness of colorectal carcinoma cells in vitro] (PubMed id 19620048)9 Wu J.B....Song Y.G. (2009)
    79. Pressure-induced vascular oxidative stress is mediate d through activation of integrin-linked kinase 1/betaPIX/Rac-1 pathway. (PubMed id 19770407)9 Vecchione C....Lembo G. (2009)
    80. Downregulation of p21-activated kinase-1 inhibits the growth of gastric cancer cells involving cyclin B1. (PubMed id 19610058)9 Liu F....Li F. (2009)
    81. Down-regulation of p21-activated kinase 1 by progestin and its increased expression in the eutopic endometrium of women with endometriosis. (PubMed id 19168872)9 Kim S.H....Kang B.M. (2009)
    82. The role of PTEN-induced kinase 1 in mitochondrial dy sfunction and dynamics. (PubMed id 19703660)9 Thomas K.J. and Cookson M.R. (2009)
    83. p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. (PubMed id 18392133)9 Li Q....Mattingly R.R. (2008)
    84. Hsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1. (PubMed id 18456663)9 Belova L....Conzen S.D. (2008)
    85. p21-activated kinase 1 promotes soluble mutant huntingtin self-interaction and enhances toxicity. (PubMed id 18065495)9 Luo S....Rubinsztein D.C. (2008)
    86. MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. (PubMed id 18922890)9 Reddy S.D....Kumar R. (2008)
    87. Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1). (PubMed id 18221368)9 Mills R.D....Cheng H.C. (2008)
    88. Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3. (PubMed id 18413761)9 Ahmad R....Kufe D. (2008)
    89. Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1. (PubMed id 18463232)9 Schuetz F....Adams D.J. (2008)
    90. High glucose promotes the CTGF expression in human mesangial cells via serum and glucocorticoid-induced kinase 1 pathway. (PubMed id 18846327)9 Wang Q....Zhu Z. (2008)
    91. Sliding p21-activated kinase 1 to nucleus impacts tamoxifen sensitivity. (PubMed id 17604944)9 Rayala S.K. and Kumar R. (2007)
    92. The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity. (PubMed id 17001318)9 Thullberg M....Stromblad S. (2007)
    93. Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. (PubMed id 17277159)9 Ahn K.S....Aggarwal B.B. (2007)
    94. p21-activated kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in human hepatoma cells. (PubMed id 17255101)9 Ishida H....Lemon S.M. (2007)
    95. p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility. (PubMed id 17609315)9 Sheehan K.A....Solaro R.J. (2007)
    96. Multiple translational isoforms give functional speci ficity to serum- and glucocorticoid-induced kinase 1. (PubMed id 17377066)9 Arteaga M.F....Canessa C.M. (2007)
    97. Exclusion of serum- and glucocorticoid-induced kinase 1 (SGK1) as a candidate gene for genetically heterogeneous renal pseudohypoaldosteronism type I in eight families. (PubMed id 17317952)9 Riepe F.G. and Holterhus P.M. (2007)
    98. Role and regulation of the serum- and glucocorticoid-regulated kinase 1 in fertile and infertile human endometrium. (PubMed id 17640988)9 Feroze-Zaidi F....Brosens J.J. (2007)
    99. Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP PNP. (PubMed id 17965184)9 Zhao B....Schnackenberg C.G. (2007)
    100. Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma. (PubMed id 17621631)9 O'Sullivan G.C....Barry O.P. (2007)
    101. Inhibition of endothelial barrier dysfunction by P21-activated kinase-1. (PubMed id 17612635)9 Ke Y....Solaro R.J. (2007)
    102. Phosphorylation-dependent regulation of stability and transforming potential of ETS transcriptional factor ESE-1 by p21-activated kinase 1. (PubMed id 17491012)9 Manavathi B....Kumar R. (2007)
    103. Phosphorylation of RhoGDI by p21-activated kinase 1. (PubMed id 16472651)9 DerMardirossian C.M. and Bokoch G.M. (2006)
    104. A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. (PubMed id 17085580)9 Xie M....Schneider M.D. (2006)
    105. Ubiquitin-proteasome degradation of serum- and glucocorticoid-regulated kinase-1 (SGK-1) is mediated by the chaperone-dependent E3 ligase CHIP. (PubMed id 16895519)9 Belova L....Conzen S.D. (2006)
    106. P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation. (PubMed id 16452229)9 Rayala S.K....Kumar R. (2006)
    107. P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts. (PubMed id 16449192)9 Rhee S. and Grinnell F. (2006)
    108. Apoptosis signal regulating kinase-1 connects reactive oxygen species to p38 MAPK-induced mitochondrial apoptosis in UVB-irradiated human keratinocytes. (PubMed id 17023263)9 Van Laethem A....Agostinis P. (2006)
    109. Activation of the mitogen- and stress-activated kinase 1 by arsenic trioxide. (PubMed id 16762916)9 Kannan-Thulasiraman P....Platanias L.C. (2006)
    110. Increased limbic phosphorylated extracellular-regulated kinase 1 and 2 expression after chronic stress is reduced by cyclic 17beta-estradiol administration. (PubMed id 16934944)9 Gerrits M....ter Horst G.J. (2006)
    111. C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1. (PubMed id 17000703)9 Sim C.H....Cheng H.C. (2006)
    112. Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3. (PubMed id 16099816)9 Bhalla V....Pearce D. (2005)
    113. STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation. (PubMed id 15764709)9 Kojima H....Nakajima K. (2005)
    114. Identification of dynein light chain 2 as an interaction partner of p21-activated kinase 1. (PubMed id 15845372)9 Lu J....Gu J. (2005)
    115. Nuclear localization and chromatin targets of p21-activated kinase 1. (PubMed id 15749698)9 Singh R.R....Kumar R. (2005)
    116. p21-Activated kinase-1 is necessary for depolarization-mediated neuronal survival. (PubMed id 15693023)9 Johnson K. and D'Mello S.R. (2005)
    117. Bradykinin stimulates cell proliferation through an extracellular-regulated kinase 1 and 2-dependent mechanism in breast cancer cells in primary culture. (PubMed id 16079255)9 Greco S....Marsigliante S. (2005)
    118. Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells. (PubMed id 15066181)9 Jung I.D....Lee H.Y. (2004)
    119. p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. (PubMed id 14970201)9 Zenke F.T....Bokoch G.M. (2004)
    120. Toll-like receptor 2 and mitogen- and stress-activated kinase 1 are effectors of Mycobacterium avium-induced cyclooxygenase-2 expression in macrophages. (PubMed id 15496409)9 Pathak S.K....Basu J. (2004)
    121. Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. (PubMed id 15153093)9 Hetman M. and Gozdz A. (2004)
    122. p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells. (PubMed id 14530270)9 Balasenthil S....Kumar R. (2004)
    123. Modulation of myosin light-chain phosphorylation by p21-activated kinase 1 in Escherichia coli invasion of human brain microvascular endothelial cells. (PubMed id 12704153)9 Rudrabhatla R.S....Prasadarao N.V. (2003)
    124. Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3. (PubMed id 12589052)9 Edlund S.... Landstrom M. (2003)
    125. Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway. (PubMed id 12733988)9 Murthy K.S....Makhlouf G.M. (2003)
    126. p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling. (PubMed id 12522133)9 Puto L.A....Bokoch G.M. (2003)
    127. Inhibition of mitogen-activated kinase kinase kinase 3 activity through phosphorylation by the serum- and glucocorticoid-induced kinase 1. (PubMed id 12761204)9 Chun J....Kang S.S. (2003)
    128. p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. (PubMed id 12151336)9 Li F....Kumar R. (2002)
    129. Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1. (PubMed id 11813163)9 Marinari B....Tuosto L. (2002)
    130. p21-activated kinase 1 activates the nuclear factor kappa B (NF-kappa B)-inducing kinase-Ikappa B kinases NF-kappa B pathway and proinflammatory cytokines in Helicobacter pylori infection. (PubMed id 11016939)9 Foryst-Ludwig A. and Naumann M. (2000)
    131. p21-activated kinase 1 plays a critical role in cellular activation by Nef. (PubMed id 10713183)9 Fackler O.T....Peterlin B.M. (2000)
    132. Expression of Eph receptor tyrosine kinases and their ligands in chick embryonic motor neurons and hindlimb muscles. (PubMed id 10646798)9 Iwamasa H....Tanaka H. (1999)
    133. A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1. (PubMed id 10471813)9 Koyano S....Yoshioka K. (1999)
    134. Molecular evidence for the early specification of presumptive functional domains in the embryonic primate cerebral cortex. (PubMed id 10407035)9 Donoghue M.J. and Rakic P. (1999)
    135. Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1. (PubMed id 9639556)9 Cuenda A. and Dorow D.S. (1998)
    136. Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. (PubMed id 9451000)9 Daniels R.H....Bokoch G.M. (1998)
    137. Endothelin-1 stimulates tyrosine phosphorylation and the activities of two mitogen-activated protein kinases in cultured vascular smooth muscle cells. (PubMed id 1334998)9 Koide M....Yokoyama M. (1992)
    138. Angiotensin II stimulates two myelin basic protein/microtubule-associated protein 2 kinases in cultured vascular smooth muscle cells. (PubMed id 1323434)9 Tsuda T....Yokoyama M. (1992)
    139. LKB1 suppresses p21-activated kinase-1 (PAK1) by phos phorylation of Thr109 in the p21-binding domain. (PubMed id 20400510)9 Deguchi A....Taketo M.M. (2010)
    140. mTOR complex-2 activates ENaC by phosphorylating SGK1 . (PubMed id 20338997)9 Lu M....Pearce D. (2010)
    141. Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indian s. (PubMed id 20185809)9 Bian L....Bogardus C. (2010)
    142. Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Ca p43-dependent suppression of angiogenic CXC chemokine expression in human pancr eatic cancer cells. (PubMed id 20416281)9 Murakami Y....Ono M. (2010)
    143. Estrogen receptor-alpha phosphorylation at serine 305 , nuclear p21-activated kinase 1 expression, and response to tamoxifen in postm enopausal breast cancer. (PubMed id 20179234)9 Bostner J....StAYl O. (2010)
    144. Tickled PINK1: mitochondrial homeostasis and autophag y in recessive Parkinsonism. (PubMed id 19595762)9 Chu C.T. (2010)
    145. Prognostic significance of integrin-linked kinase1 ov erexpression in astrocytoma. (PubMed id 19676046)9 Li J....Li M. (2010)
    146. Cell-type-specific roles of IGF-1R and EGFR in mediat ing Zn2+-induced ERK1/2 and PKB phosphorylation. (PubMed id 19946718)9 Pandey N.R....Srivastava A.K. (2010)
    147. Hunting for serine 276-phosphorylated p65. (PubMed id 20204068)9 Spooren A....Gerlo S. (2010)
    148. BAK7 displays unequal genetic redundancy with BAK1 in brassinosteroid signaling and early senescence in Arabidopsis. (PubMed id 20108170)9 Jeong Y.J....Nam K.H. (2010)
    149. Formation of parkin aggregates and enhanced PINK1 acc umulation during the pathogenesis of Parkinson's disease. (PubMed id 20171192)9 Um J.W....Chung K.C. (2010)
    150. Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1. (PubMed id 19410195)9 Brems H....Legius E. (2009)
    151. Uptake of plasmid-loaded nanoparticles in breast canc er cells and effect on Plk1 expression. (PubMed id 19591537)9 Steinhauser I....SpAonkuch B. (2009)
    152. Deoxypodophyllotoxin, flavolignan, from Anthriscus sylvestris Hoffm. inhibits migration and MMP-9 via MAPK pathways in TNF-alpha-induced HASMC. (PubMed id 19013539)9 Suh S.J....Kim C.H. (2009)
    153. Mitochondrial autophagy as a compensatory response to PINK1 deficiency. (PubMed id 19786829)9 Cherra S.J....Chu C.T. (2009)
    154. Neutrophil elastase cleaves VEGF to generate a VEGF fragment with altered activity. (PubMed id 19136576)9 Kurtagic E....Nugent M.A. (2009)
    155. Epithelial sodium channel regulated by differential composition of a signaling complex. (PubMed id 19380724)9 Soundararajan R....Pearce D. (2009)
    156. Role of p47(phox) in regulating Cdc42GAP, vimentin, a nd contraction in smooth muscle cells. (PubMed id 19812368)9 Li Q.F. and Tang D.D. (2009)
    157. miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia. (PubMed id 19258499)9 Pigazzi M....Basso G. (2009)
    158. Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission. (PubMed id 19279012)9 Dagda R.K....Chu C.T. (2009)
    159. SGK1 activity in Na+ absorbing airway epithelial cells monitored by assaying NDRG1-Thr346/356/366 phosphorylation. (PubMed id 18787837)9 Inglis S.K....Wilson S.M. (2009)
    160. X-linked inhibitor of apoptosis protein and its E3 li gase activity promote transforming growth factor-{beta}-mediated nuclear factor -{kappa}B activation during breast cancer progression. (PubMed id 19531477)9 Neil J.R....Schiemann W.P. (2009)
    161. Paraquat activates the IRE1/ASK1/JNK cascade associat ed with apoptosis in human neuroblastoma SH-SY5Y cells. (PubMed id 19735704)9 Yang W....Son I.H. (2009)
    162. Redox activated MAP kinase death signaling cascade in itiated by ASK1 is not activated in female mice following MPTP: novel mechanism of neuroprotection. (PubMed id 19526288)9 Saeed U....Ravindranath V. (2009)
    163. Hsp90 transcriptionally and post-translationally regu lates the expression of NDRG1 and maintains the stability of its modifying kina se GSK3beta. (PubMed id 19682504)9 Banz V.M....Stroka D. (2009)
    164. Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens. (PubMed id 19363496)9 Fan A.C....Felsher D.W. (2009)
    165. TNF receptors differentially signal and are different ially expressed and regulated in the human heart. (PubMed id 19788501)9 Al-Lamki R.S....Bradley J.R. (2009)
    166. The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process. (PubMed id 19056353)9 Park J....Chung J. (2009)
    167. Aldosterone mediates activation of the thiazide-sensi tive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. (PubMed id 19690383)9 Rozansky D.J....Ellison D.H. (2009)
    168. Microarray analysis of differentially expressed genes in the brains of tubby mice. (PubMed id 19885003)9 Lee J.H....Ahn Y.S. (2009)
    169. Regulation of a third conserved phosphorylation site in SGK1. (PubMed id 19068477)9 Chen W....Cobb M.H. (2009)
    170. Existence of Pink1 antisense RNAs in mouse and their localization. (PubMed id 20068297)9 Chiba M....Yasue H. (2009)
    171. Striking the balance between PTEN and PDK1: it all de pends on the cell context. (PubMed id 19651981)9 Iwanami A....Mischel P.S. (2009)
    172. Mitochondrial quality control: insights on how Parkin son's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain m itochondrial homeostasis. (PubMed id 20012177)9 Dagda R.K. and Chu C.T. (2009)
    173. Curcumin suppresses proliferation and invasion in hum an gastric cancer cells by downregulation of PAK1 activity and cyclin D1 expres sion. (PubMed id 19448398)9 Cai X.Z....Li F. (2009)
    174. Molecular basis of Parkinson's disease. (PubMed id 19151598)9 Yang Y.X....Latchman D.S. (2009)
    175. Mitochondrial kinases in Parkinson's disease: converg ing insights from neurotoxin and genetic models. (PubMed id 19563915)9 Dagda R.K....Chu C.T. (2009)
    176. TRAF6 establishes innate immune responses by activati ng NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA. (PubMed id 19479062)9 Konno H....Inoue J. (2009)
    177. A mechanism for the suppression of interleukin-1-indu ced nuclear factor kappaB activation by protein phosphatase 2Ceta-2. (PubMed id 19594441)9 Henmi T....Kobayashi T. (2009)
    178. Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes. (PubMed id 18923061)9 Sheehan K.A....Solaro R.J. (2009)
    179. Regulation of PINK1 by NR2B-containing NMDA receptors in ischemic neuronal injury. (PubMed id 19780893)9 Shan Y....Wan Q. (2009)
    180. CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1. (PubMed id 19805025)9 Yoon K.W.... Choi E.J. (2009)
    181. Tumor necrosis factor-alpha induced expression of matrix metalloproteinase-9 through p21-activated kinase-1. (PubMed id 19298660)9 Zhou L....Han Y.P. (2009)
    182. Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K -Akt pathway as potential target. (PubMed id 19920184)9 Gu M....Agarwal R. (2009)
    183. Regulation of potassium (K) handling in the renal collecting duct. (PubMed id 18839206)9 Wang W.H. and Giebisch G. (2009)
    184. Dissecting activation of the PAK1 kinase at protrusio ns in living cells. (PubMed id 19574218)9 Parrini Gunzburg J. (2009)
    185. Inhibitory effects of adiponectin on platelet-derived growth factor-induced mesangial cell migration. (PubMed id 19460854)9 Ishizawa K....Tamaki T. (2009)
    186. Urokinase mediates endothelial cell survival via induction of the X-linked inhibitor of apoptosis protein. (PubMed id 18948573)9 Prager G.W....Binder B.R. (2009)
    187. Protective effect of selenite on renal ischemia/reper fusion injury through inhibiting ASK1-MKK3-p38 signal pathway. (PubMed id 20003709)9 Wang Y....Qiu S.L. (2009)
    188. Requirement of JNK-mediated phosphorylation for trans location of group IVA phospholipase A2 to phagosomes in human macrophages. (PubMed id 19625654)9 Casas J....Balboa M.A. (2009)
    189. Administration of glucocorticoids to ovarian cancer patients is associated with expression of the anti-apoptotic genes SGK1 and MKP1/DUSP1 in ovarian tissues. (PubMed id 19383827)9 Melhem A....Conzen S.D. (2009)
    190. Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling. (PubMed id 18762249)9 Winkel A....Hoffmann A. (2008)
    191. Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy. (PubMed id 17891170)9 Nieto-Miguel T....Mollinedo F. (2008)
    192. The PINK1/Parkin pathway regulates mitochondrial morphology. (PubMed id 18230723)9 Poole A.C....Pallanck L.J. (2008)
    193. Mitogen- and stress-activated kinase 1-mediated histone H3 phosphorylation is crucial for cell transformation. (PubMed id 18381464)9 Kim H.G....Dong Z. (2008)
    194. Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer. (PubMed id 18823530)9 Lundgren K....Landberg G. (2008)
    195. Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells. (PubMed id 18768391)9 McDaniel A.S....Clapp D.W. (2008)
    196. Analysis of protein phosphorylation by monolithic extraction columns based on poly(divinylbenzene) containing embedded titanium dioxide and zirconium dioxide nano-powders. (PubMed id 18837466)9 Rainer M....Bonn G.K. (2008)
    197. Protein kinase D1: a new component in TLR9 signaling. (PubMed id 18641342)9 Park J.E....Yi A.K. (2008)
    198. Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways. (PubMed id 18778461)9 Nilsson D....Malmsjo M. (2008)
    199. Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration. (PubMed id 19076450)9 Knott A.B. and Bossy-Wetzel E. (2008)
    200. Regulation of epithelial Na+ channels by aldosterone: role of Sgk1. (PubMed id 18197893)9 Lee I.H....Dinudom A. (2008)
    201. Involvement of thioredoxin-binding protein 2 in the antitumor activity of CD437. (PubMed id 19018770)9 Matsuoka S....Shiota G. (2008)
    202. The novel isoflavone 7-hydroxy-3',4'-benzoisoflavone induces cell apoptosis in human osteosarcoma cells. (PubMed id 18606492)9 Hou C.H....Tang C.H. (2008)
    203. 3,4,5-trihydroxybenzaldehyde from Geum japonicum has dual inhibitory effect on matrix metalloproteinase 9; inhibition of gelatinoytic activity as well as MMP-9 expression in TNF-alpha induced HASMC. (PubMed id 18773430)9 Suh S.J....Kim C.H. (2008)
    204. A 39 kDa fragment of endogenous ASK1 suggests specific cleavage not degradation by the proteasome. (PubMed id 18380010)9 Stordal B. and Davey R. (2008)
    205. mTORC2 is the hydrophobic motif kinase for SGK1. (PubMed id 19025518)9 Yan L....Lamb R.F. (2008)
    206. Antidepressants induce acute CREB phosphorylation and CRE-mediated gene expression in glial cells: a possible contribution to GDNF production. (PubMed id 18234163)9 Hisaoka K....Takebayashi M. (2008)
    207. The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. (PubMed id 18758450)9 Sorrentino A.... Landstrom M. (2008)
    208. Science signaling podcast: 02 december 2008. (PubMed id 19050302)9 Lee S.W....Vanhook A.M. (2008)
    209. Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism. (PubMed id 18492799)9 Maussion G....Simonneau M. (2008)
    210. TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaB. (PubMed id 18070982)9 Muroi M. and Tanamoto K. (2008)
    211. Phosphorylation of the ErbB3 binding protein Ebp1 by p21-activated kinase 1 in breast cancer cells. (PubMed id 18283314)9 Akinmade D....Hamburger A.W. (2008)
    212. Subversion of CtBP1-controlled macropinocytosis by human adenovirus serotype 3. (PubMed id 18323776)9 Amstutz B....Greber U.F. (2008)
    213. High D-glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium. (PubMed id 18064606)9 Puebla C....Sobrevia L. (2008)
    214. Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions. (PubMed id 18084006)9 Song C....Kumar R. (2008)
    215. Modulation of ER phosphorylation on serine 118 by endocrine therapy: a new surrogate marker for efficacy. (PubMed id 18436523)9 Zoubir M....Andre F. (2008)
    216. A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons. (PubMed id 18334630)9 Arteaga M.F.... Canessa C.M. (2008)
    217. Induction of serum- and glucocorticoid-induced kinase-1 (SGK1) by cAMP regulates increases in alpha-ENaC. (PubMed id 18615584)9 Vasquez M.M....Mustafa S.B. (2008)
    218. Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. (PubMed id 18054038)9 Mao K....Liang Q. (2008)
    219. Transforming growth factor-beta-activated protein kinase 1-binding protein (TAB)-1alpha, but not TAB1beta, mediates cytokine-induced p38 mitogen-activated protein kinase phosphorylation and cell death in insulin-producing cells. (PubMed id 17932218)9 Makeeva N....Welsh N. (2008)
    220. Regulation Fe65 localization to the nucleus by SGK1 phosphorylation of its Ser566 residue. (PubMed id 18304449)9 Lee E.J....Kang S.S. (2008)
    221. PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins. (PubMed id 18515095)9 He H....Baldwin G.S. (2008)
    222. [Parkin and mitochondria] (PubMed id 18717196)9 Mitsui T....Kaji R. (2008)
    223. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. (PubMed id 18381444)9 Rhodes N....Kumar R. (2008)
    224. RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells. (PubMed id 19015318)9 Ordonez-Moran P....Munoz A. (2008)
    225. N-terminus-mediated dimerization of ROCK-I is required for RhoE binding and actin reorganization. (PubMed id 18215121)9 Garg R....Ridley A.J. (2008)
    226. Differential p38 mitogen-activated protein kinase-controlled hypophosphorylation of the retinoblastoma protein induced by nitric oxide in neuroblastoma cells. (PubMed id 17976389)9 GonzA!lez-FernA!ndez O....Villalobo A. (2008)
    227. Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model. (PubMed id 18353870)9 Nishimura H....Matsuo S. (2008)
    228. Coexistence of mutations in PINK1 and mitochondrial DNA in early onset parkinsonism. (PubMed id 18524835)9 Piccoli C....Capitanio N. (2008)
    229. Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis. (PubMed id 18160398)9 Roepstorff K....Vilhardt F. (2008)
    230. L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner. (PubMed id 18359116)9 Moriwaki Y....Takahashi R. (2008)
    231. PAMP-triggered immunity: Early events in the activati on of FLAGELLIN SENSITIVE2. (PubMed id 19704848)9 Ali G.S. and Reddy A. (2008)
    232. Biochemical and structural characterization of the Pak1-LC8 interaction. (PubMed id 18650427)9 Lightcap C.M....Williams J.C. (2008)
    233. The mitochondrial superoxide/thioredoxin-2/Ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes. (PubMed id 17975114)9 Lim P.L....Boelsterli U.A. (2008)
    234. Protein kinase C zeta. A novel regulator of both phosphorylation and de-phosphorylation of cardiac sarcomeric proteins. (PubMed id 17724026)9 Wu S.C. and Solaro R.J. (2007)
    235. Pseudomonas aeruginosa and sPLA2 IB stimulate ABCA1-mediated phospholipid efflux via ERK-activation of PPARalpha-RXR. (PubMed id 17223797)9 Agassandian M....Mallampalli R.K. (2007)
    236. IL-20 gene expression is induced by IL-1beta through mitogen-activated protein kinase and NF-kappaB-dependent mechanisms. (PubMed id 17255956)9 Otkjaer K....Iversen L. (2007)
    237. Coactivator-mediated estrogen response in human squamous cell carcinoma lines. (PubMed id 17400812)9 Ku T.K. and Crowe D.L. (2007)
    238. Dynamic interplay between nitration and phosphorylation of tubulin cofactor B in the control of microtubule dynamics. (PubMed id 18048340)9 Rayala S.K....Kumar R. (2007)
    239. TAB1 modulates IL-1alpha mediated cytokine secretion but is dispensable for TAK1 activation. (PubMed id 17052891)9 Bertelsen M. and Sanfridson A. (2007)
    240. Chemoresistance of endothelial cells induced by basic fibroblast growth factor depends on Raf-1-mediated inhibition of the proapoptotic kinase, ASK1. (PubMed id 17363598)9 Alavi A.S....Cheresh D.A. (2007)
    241. Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease. (PubMed id 17499497)9 Dodson M.W. and Guo M. (2007)
    242. Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide. (PubMed id 17348859)9 Windheim M....Cohen P. (2007)
    243. Possible implications of redox-sensitive tumour cell transformation; lessons from cell culture studies. (PubMed id 17882938)9 Orzechowski A. (2007)
    244. Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation. (PubMed id 17505005)9 Bhutani M....Aggarwal B.B. (2007)
    245. Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase. (PubMed id 17420447)9 Acconcia F....Kumar R. (2007)
    246. TAK1 represses transcription of the human telomerase reverse transcriptase gene. (PubMed id 17325661)9 Fujiki T....Katakura Y. (2007)
    247. Inhibition of Galphaq-dependent PLC-beta1 activity by PKG and PKA is mediated by phosphorylation of RGS4 and GRK2. (PubMed id 16885398)9 Huang J....Murthy K.S. (2007)
    248. Heregulin-mediated ErbB2-ERK signaling activates hyaluronan synthases leading to CD44-dependent ovarian tumor cell growth and migration. (PubMed id 17493932)9 Bourguignon L.Y....Peyrollier K. (2007)
    249. Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer. (PubMed id 17486065)9 Bostner J....Stal O. (2007)
    250. PINK1 mutation heterozygosity and the risk of Parkinson's disease. (PubMed id 17172567)9 Toft M....Farrer M.J. (2007)
    251. Effect of exercise and insulin on SREBP-1c expression in human skeletal muscle: potential roles for the ERK1/2 and Akt signalling pathways. (PubMed id 17956338)9 Boonsong T....Tsintzas K. (2007)
    252. Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IkappaB kinase in hepatic macrophages. (PubMed id 17172471)9 Chen L....Tsukamoto H. (2007)
    253. The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function. (PubMed id 17362513)9 Scheele C....Timmons J.A. (2007)
    254. PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c. (PubMed id 17707122)9 Wang H.L....Yu S.T. (2007)
    255. Nitric oxide down-regulates polo-like kinase 1 through a proximal promoter cell cycle gene homology region. (PubMed id 17121839)9 Zhang J....Danner R.L. (2007)
    256. 17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines. (PubMed id 17308059)9 Mitchell C....Dent P. (2007)
    257. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. (PubMed id 17611497)9 Carpten J.D.... Thomas J.E. (2007)
    258. Spinal cord injury induces endoplasmic reticulum stress with different cell-type dependent response. (PubMed id 17578450)9 Penas C....Casas C. (2007)
    259. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. (PubMed id 17563363)9 Kitada T....Shen J. (2007)
    260. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. (PubMed id 17579517)9 Pridgeon J.W....Li L. (2007)
    261. DJ-1: a newcomer in Parkinson's disease pathology. (PubMed id 18045143)9 da Costa C.A. (2007)
    262. Contrasting roles of neuronal Msk1 and Rsk2 in Bad phosphorylation and feedback regulation of Erk signalling. (PubMed id 17663748)9 Clark C.J....Morris B.J. (2007)
    263. A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion. (PubMed id 17997827)9 Mitsios N....Slevin M. (2007)
    264. Lim kinases, regulators of actin dynamics. (PubMed id 17188549)9 Bernard O. (2007)
    265. Impact of recent genetic findings in Parkinson's disease. (PubMed id 17620882)9 Klein C. and Lohmann-Hedrich K. (2007)
    266. Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS. (PubMed id 17117922)9 McCoy C.E....Arthur J.S. (2007)
    267. PKC-alpha and TAK-1 are intermediates in the activation of c-Jun NH2-terminal kinase by hypoxia-reoxygenation. (PubMed id 17209006)9 Frazier D.P....Webster K.A. (2007)
    268. Salt, sodium channels, and SGK1. (PubMed id 17332888)9 Pearce D. and Kleyman T.R. (2007)
    269. A critical review of the therapeutic potential of dib enzyl trisulphide isolated from Petiveria alliacea L (guinea hen weed, anamu). (PubMed id 17621839)9 Williams L.A....Barton E.N. (2007)
    270. Phosphorylated Pak1 level in the cytoplasm correlates with shorter survival time in patients with glioblastoma. (PubMed id 18006760)9 Aoki H....Kondo Y. (2007)
    271. Requirement for both JAK-mediated PI3K signaling and ACT1/TRAF6/TAK1-dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells. (PubMed id 17982039)9 Huang F....Wu R. (2007)
    272. Candida albicans triggers activation of distinct signaling pathways to establish a proinflammatory gene expression program in primary human endothelial cells. (PubMed id 18056390)9 MA1ller V....Goebeler M. (2007)
    273. TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells. (PubMed id 16492740)9 Gerbod-Giannone M.C....Tall A.R. (2006)
    274. Association of PINK1 and DJ-1 confers digenic inheritance of early- onset Parkinson's disease. (PubMed id 16632486)9 Tang B.... Zhang Z. (2006)
    275. Assessment of PINK1 (PARK6) polymorphisms in Finnish PD. (PubMed id 16046032)9 Clarimon J....Singleton A.B. (2006)
    276. Sphingosine-1-phosphate acts via rho-associated kinas e and nitric oxide to regulate human placental vascular tone. (PubMed id 16162874)9 Hemmings D.G....Taggart M.J. (2006)
    277. PAK1 hyperactivation is sufficient for mammary gland tumor formation. (PubMed id 16331248)9 Wang R.A....Kumar R. (2006)
    278. Melanoma genomics reveals signatures of sensitivity to bio- and targeted therapies. (PubMed id 17433276)9 TA-mA!r J....RA!sA^ E. (2006)
    279. Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides. (PubMed id 16537514)9 Schirmer A....Santi D.V. (2006)
    280. Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors. (PubMed id 16790082)9 Goldstein M....Orr-Urtreger A. (2006)
    281. Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients. (PubMed id 16705121)9 Holm C....Landberg G. (2006)
    282. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. (PubMed id 16672981)9 Clark I.E....Guo M. (2006)
    283. The PAK1 autoregulatory domain is required for interaction with NIK in Helicobacter pylori-induced NF-kappaB activation. (PubMed id 16497167)9 Neumann M....Naumann M. (2006)
    284. Hsp90 increases LIM kinase activity by promoting its homo-dimerization. (PubMed id 16641196)9 Li R....Bernard O. (2006)
    285. An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway. (PubMed id 17110930)9 Nakajima A....Nakano H. (2006)
    286. Increased p21-activated kinase-1 expression is associated with invasive potential in uveal melanoma. (PubMed id 16845324)9 Pavey S....Hayward N. (2006)
    287. Prostate-specific membrane antigen regulates angiogenesis by modulating integrin signal transduction. (PubMed id 16809768)9 Conway R.E....Shapiro L.H. (2006)
    288. PAK1 and aPKCzeta regulate myosin II-B phosphorylation: a novel signaling pathway regulating filament assembly. (PubMed id 16611744)9 Even-Faitelson L. and Ravid S. (2006)
    289. Induction of apoptosis by p110C requires mitochondrial translocation of the proapoptotic BCL-2 family member BAD. (PubMed id 16413544)9 Chen C....Gu J. (2006)
    290. Xenopus death-domain-containing proteins FADD and RIP1 synergistically activate JNK and NF-kappaB. (PubMed id 16597320)9 Ishizawa Y.H....Ito M. (2006)
    291. Tumor inhibition by genomically integrated inducible RNAi-cassettes. (PubMed id 16945954)9 Kappel S....Strebhardt K. (2006)
    292. Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis. (PubMed id 16262601)9 Cao H....Blackshear P.J. (2006)
    293. Role of Rac1 in Escherichia coli K1 invasion of human brain microvascular endothelial cells. (PubMed id 16243562)9 Rudrabhatla R.S....Prasadarao N.V. (2006)
    294. [A 62-year-old woman with early-onset Parkinson's dis ease associated with the PINKi gene deletion] (PubMed id 16642930)9 Atsumi M....Hattori N. (2006)
    295. A common A340T variant in PINK1 gene associated with late-onset Parkinson's disease in Chinese. (PubMed id 17084972)9 Wang F....Chan P. (2006)
    296. MyD88 and TNF receptor-associated factor 6 are critical signal transducers in Helicobacter pylori-infected human epithelial cells. (PubMed id 16517750)9 Hirata Y....Omata M. (2006)
    297. Comparative integromics on Eph family. (PubMed id 16596241)9 Katoh M. and Katoh M. (2006)
    298. Putative dual role of ephrin-Eph receptor interactions in inflammation. (PubMed id 16801213)9 Ivanov A.I. and Romanovsky A.A. (2006)
    299. Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on TNF-alpha-induced matrix metalloproteinase-9 production and HASMC migration via down-regulated NF-kappaB and AP-1. (PubMed id 16999937)9 Suh S.J....Kim C.H. (2006)
    300. Nuclear p21-activated kinase 1 in breast cancer packs off tamoxifen sensitivity. (PubMed id 16778166)9 Rayala S.K....Kumar R. (2006)
    301. Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells. (PubMed id 16532036)9 Mochizuki T....Kamata T. (2006)
    302. Integrin alphaVbeta3 contains a receptor site for resveratrol. (PubMed id 16790523)9 Lin H.Y....Davis P.J. (2006)
    303. Mitogen- and stress-activated protein kinase 1 is critical for interleukin-1-induced, CREB-mediated, c-fos gene expression in keratinocytes. (PubMed id 16532028)9 Schiller M....Mauviel A. (2006)
    304. A Phosphatidylinositol 3-kinase-regulated Akt-independent signaling promotes cigarette smoke-induced FRA-1 expression. (PubMed id 16490785)9 Zhang Q....Reddy S.P. (2006)
    305. Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex. (PubMed id 16543409)9 Frobose H....Billestrup N. (2006)
    306. SGK1 activates Na+-K+-ATPase in amphibian renal epithelial cells. (PubMed id 16192298)9 Alvarez de la Rosa D....Canessa C.M. (2006)
    307. Glucocorticoid receptor activation signals through forkhead transcription factor 3a in breast cancer cells. (PubMed id 16690749)9 Wu W....Conzen S.D. (2006)
    308. Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages. (PubMed id 16365431)9 Sekine Y....Matsuda T. (2006)
    309. Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via preferential activation of the PI3K/ILK pathway. (PubMed id 16472257)9 Huang J....Murthy K.S. (2006)
    310. Vasoactive intestinal peptide induces neuroendocrine differentiation in the LNCaP prostate cancer cell line through PKA, ERK, and PI3K. (PubMed id 15468165)9 GutiAcrrez-CaA+as I....Carmena M.J. (2005)
    311. Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells. (PubMed id 16322251)9 Asanuma H....Sato N. (2005)
    312. TGF beta signalling and its role in tumour pathogenesis. (PubMed id 15990918)9 Kaminska B....Danilkiewicz M. (2005)
    313. Subcellular targeting of oxidants during endothelial cell migration. (PubMed id 16330715)9 Wu R.F.... Terada L.S. (2005)
    314. Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. (PubMed id 15864311)9 Phee H....Weiss A. (2005)
    315. Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection. (PubMed id 15688034)9 Fan S....Rosen E.M. (2005)
    316. TNFR1- and TNFR2-mediated signaling pathways in human kidney are cell type-specific and differentially contribute to renal injury. (PubMed id 16195372)9 Al-Lamki R.S....Bradley J.R. (2005)
    317. Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y. (PubMed id 16226715)9 Deng H....Le W. (2005)
    318. Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes. (PubMed id 15713122)9 Hers I. and Tavare J.M. (2005)
    319. Angiotensin II-induced activation of p21-activated kinase 1 requires Ca2+ and protein kinase C{delta} in vascular smooth muscle cells. (PubMed id 16033904)9 Woolfolk E.A....Motley E.D. (2005)
    320. Sgk1, a cell survival response in neurodegenerative diseases. (PubMed id 16125969)9 Schoenebeck B....Stichel C.C. (2005)
    321. Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine. (PubMed id 15766329)9 Tang D.D....Gunst S.J. (2005)
    322. Coordinate expression of the PI3-kinase downstream effectors serum and glucocorticoid-induced kinase (SGK-1) and Akt-1 in human breast cancer. (PubMed id 16246546)9 Sahoo S....Conzen S.D. (2005)
    323. Regulation of GDF-8 signaling by the p38 MAPK. (PubMed id 15567067)9 Philip B....Gao Y. (2005)
    324. p38 mitogen-activated protein kinase downregulates endothelial progenitor cells. (PubMed id 15753227)9 Seeger F.H....Dimmeler S. (2005)
    325. PAK1 regulates myosin II-B phosphorylation, filament assembly, localization and cell chemotaxis. (PubMed id 15993754)9 Even-Faitelson L....Ravid S. (2005)
    326. Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells. (PubMed id 15217905)9 Su J.L....Kuo M.L. (2005)
    327. The cytokine IL-1beta activates IFN response factor 3 in human fetal astrocytes in culture. (PubMed id 15749911)9 Rivieccio M.A....Brosnan C.F. (2005)
    328. Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease. (PubMed id 15635602)9 Webber K.M....Zhu X. (2005)
    329. A single pair of acidic residues in the kinase major groove mediates strong substrate preference for P-2 or P-5 arginine in the AGC, CAMK, and STE kinase families. (PubMed id 16131491)9 Zhu G....Shaw S. (2005)
    330. Transforming growth factor (TGF)-beta-activated kinase 1 mimics and mediates TGF-beta-induced stimulation of type II collagen synthesis in chondrocytes independent of Col2a1 transcription and Smad3 signaling. (PubMed id 15743758)9 Qiao B....Benya P.D. (2005)
    331. Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions. (PubMed id 15833848)9 Yang Z....Kumar R. (2005)
    332. Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. (PubMed id 15983381)9 Junn E....Mouradian M.M. (2005)
    333. Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship. (PubMed id 16221215)9 von Wowern F....Melander O. (2005)
    334. Transforming growth factor beta-activated kinase 1 is a key mediator of ovine follicle-stimulating hormone beta-subunit expression. (PubMed id 16081641)9 Safwat N....Miller W.L. (2005)
    335. Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. (PubMed id 16079129)9 Petit A....Tandon A. (2005)
    336. Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. (PubMed id 15713627)9 Parsons M....Ng T. (2005)
    337. Angiotensin II promotes leptin production in cultured human fat cells by an ERK1/2-dependent pathway. (PubMed id 15976138)9 Skurk T....Hauner H. (2005)
    338. Changes in retinal gene expression in proliferative vitreoretinopathy: glial cell expression of HB-EGF. (PubMed id 15988409)9 Hollborn M....Bringmann A. (2005)
    339. TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation. (PubMed id 15814732)9 Liu-Bryan R....Terkeltaub R. (2005)
    340. X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1). (PubMed id 16157589)9 Kaur S....Arsura M. (2005)
    341. Spatiotemporal regulation of the Pak1 kinase. (PubMed id 16042564)9 Parrini Gunzburg J. (2005)
    342. TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd. (PubMed id 16251197)9 Morlon A....Smahi A. (2005)
    343. Modulation of the p38 MAPK (mitogen-activated protein kinase) pathway through Bcr/Abl: implications in the cellular response to Ara-C. (PubMed id 15540985)9 Sanchez-Arevalo Lobo V.J....Sanchez-Prieto R. (2005)
    344. Identification of ASK1, MKK4, JNK, c-Jun, and caspase-3 as a signaling cascade involved in cadmium-induced neuronal cell apoptosis. (PubMed id 15670787)9 Kim S.D....Jo S.A. (2005)
    345. Depressed tumor necrosis factor alpha and interleukin-12p40 production by peripheral blood mononuclear cells of gastric cancer patients: association with IL-1R-associated kinase-1 protein expression and disease stage. (PubMed id 15523691)9 Siedlar M....Zembala M. (2005)
    346. Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells. (PubMed id 15178330)9 Balasenthil S....Kumar R. (2004)
    347. S-nitrosation of thioredoxin in the nitrogen monoxide/superoxide system activates apoptosis signal-regulating kinase 1. (PubMed id 15246877)9 Yasinska I.M.... Sumbayev V.V. (2004)
    348. Role of E2F and ERK1/2 in STI571-mediated smooth muscle cell growth arrest and cyclin A transcriptional repression. (PubMed id 15094364)9 Sanz-GonzA!lez S.M....AndrAcs V. (2004)
    349. Inactivation of ERK accelerates erythroid differentiation of K562 cells induced by herbimycin A and STI571 while activation of MEK1 interferes with it. (PubMed id 15030167)9 Kawano T....Yamada H. (2004)
    350. Membrane type 1 matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-related kinase activation and cell migration. (PubMed id 14871836)9 Takino T....Sato H. (2004)
    351. p90 ribosomal S6 kinase 2 is associated with and dephosphorylated by protein phosphatase 2Cdelta. (PubMed id 15206906)9 Doehn U....Jensen C.J. (2004)
    352. p21-activated kinase 1: an emerging therapeutic targe t. (PubMed id 15164874)9 Vadlamudi R.K. and Kumar R. (2004)
    353. Amidine analogue of chlorambucil is a stronger inhibitor of protein and DNA synthesis in breast cancer MCF-7 cells than is the parent drug. (PubMed id 15178351)9 Sienkiewicz P....PaA8ka J. (2004)
    354. The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein. (PubMed id 15274926)9 Smith K.J....Reith A. (2004)
    355. Mechanisms of mineralocorticoid action: determinants of receptor specificity and actions of regulated gene products. (PubMed id 15109612)9 Bhargava A. and Pearce D. (2004)
    356. p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate. (PubMed id 14749719)9 Vadlamudi R.K....Kumar R. (2004)
    357. Co-aggregation of FcgammaRII with FcepsilonRI on human mast cells inhibits antigen-induced secretion and involves SHIP-Grb2-Dok complexes. (PubMed id 15151996)9 Kepley C.L....Saxon A. (2004)
    358. Signalling pathways for insulin-like growth factor type 1-mediated expression of uncoupling protein 3. (PubMed id 14690534)9 Gustafsson H....Forsby A. (2004)
    359. Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain. (PubMed id 15139849)9 Cross J.V. and Templeton D.J. (2004)
    360. Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. (PubMed id 15193260)9 Vadlamudi R.K....Kumar R. (2004)
    361. Pak-1 expression increases with progression of colorectal carcinomas to metastasis. (PubMed id 15161701)9 Carter J.H....Graff J.R. (2004)
    362. Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) gamma2 gene expression in brown adipocytes: intracellular signalling and effects on PPARgamma2 and PPARgamma1 protein levels. (PubMed id 15193150)9 Lindgren E.M....Nedergaard J. (2004)
    363. Identification and cloning of genes displaying elevated expression as a consequence of metastatic progression in human melanoma cells by rapid subtraction hybridization. (PubMed id 15563845)9 Boukerche H....Fisher P.B. (2004)
    364. Human immunodeficiency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant production. (PubMed id 14694110)9 Wu R.F....Terada L.S. (2004)
    365. Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. (PubMed id 14764725)9 Asehnoune K....Abraham E. (2004)
    366. Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism. (PubMed id 15208259)9 Verdier-Sevrain S....Gilchrest B.A. (2004)
    367. The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells. (PubMed id 14760089)9 Yang Z....Kumar R. (2004)
    368. TGF-beta1 and angiotensin networking in cardiac remodeling. (PubMed id 15276467)9 Rosenkranz S. (2004)
    369. The biochemical response of the heart to hypertension and exercise. (PubMed id 15501680)9 Wakatsuki T....Elson E.L. (2004)
    370. Protein kinase Czeta mediated Raf-1/extracellular-regulated kinase activation by daunorubicin. (PubMed id 12406911)9 Mas V.M....Laurent G. (2003)
    371. Vitamin D growth inhibition of breast cancer cells: gene expression patterns assessed by cDNA microarray. (PubMed id 12889598)9 Swami S....Feldman D. (2003)
    372. Human neutrophils utilize a Rac/Cdc42-dependent MAPK pathway to direct intracellular granule mobilization toward ingested microbial pathogens. (PubMed id 12511425)9 Zhong B....Wei S. (2003)
    373. Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein. (PubMed id 12874243)9 Jensen L.E. and Whitehead A.S. (2003)
    374. TGFbeta1 activates c-Jun and Erk1 via alphaVbeta6 integrin. (PubMed id 14572313)9 Luettich K. and Schmidt C. (2003)
    375. TGF-beta1 suppresses apoptosis via differential regulation of MAP kinases and ceramide production. (PubMed id 12728250)9 Chen H.H....Song J.G. (2003)
    376. Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. (PubMed id 14580336)9 Kissil J.L....Jacks T. (2003)
    377. Ets2 and protein kinase C epsilon are important regulators of parathyroid hormone-related protein expression in MCF-7 breast cancer cells. (PubMed id 12628005)9 Lindemann R.K....Dittmer J. (2003)
    378. Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise. (PubMed id 12527721)9 Yu M....Zierath J.R. (2003)
    379. Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. (PubMed id 12941695)9 Muller J....Morrison D.K. (2003)
    380. Tumor necrosis factor-alpha induces interleukin-6 production via extracellular-regulated kinase 1 activation in breast cancer cells. (PubMed id 12889600)9 Suarez-Cuervo C....Selander K.S. (2003)
    381. Phorbol ester-induced migration of HepG2 cells is accompanied by intensive stress fibre formation, enhanced integrin expression and transient down-regulation of p21-activated kinase 1. (PubMed id 12531429)9 Gujdar A....Farago A. (2003)
    382. EGF activates an inducible survival response via the RAS-> Erk-1/2 pathway to counteract interferon-alpha-mediated apoptosis in e pidermoid cancer cells. (PubMed id 12700650)9 Caraglia M....Abbruzzese A. (2003)
    383. Functional inactivation of a transcriptional corepressor by a signaling kinase. (PubMed id 12872159)9 Barnes C.J....Kumar R. (2003)
    384. Association of a haplotype (196Phe/532Ser) in the interleukin-1-receptor-associated kinase (IRAK1) gene with low radial bone mineral density in two independent populations. (PubMed id 12619925)9 Ishida R....Orimo H. (2003)
    385. Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition. (PubMed id 12551923)9 Tran N.H. and Frost J.A. (2003)
    386. Amphiregulin is a potent mitogen for the vascular smooth muscle cell line, A7r5. (PubMed id 12589827)9 Kato M....Miyamori I. (2003)
    387. CBF1 controls the retinotectal topographical map along the anteroposterior axis through multiple mechanisms. (PubMed id 12954716)9 Takahashi H....Noda M. (2003)
    388. The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization. (PubMed id 12829723)9 Hashimoto Y....Nishimoto I. (2003)
    389. Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells. (PubMed id 12560069)9 Mazumdar A. and Kumar R. (2003)
    390. Hepatitis C virus proteins do not directly trigger fibrogenic events in cultured human liver myofibroblasts. (PubMed id 14633175)9 Tan K....Rosenbaum J. (2003)
    391. Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways. (PubMed id 14575865)9 Menard R.E. and Mattingly R.R. (2003)
    392. E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions. (PubMed id 12649084)9 Yoshida M....Kimura A. (2003)
    393. Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643. (PubMed id 12729718)9 Vanden Heuvel J.P....Taylor M.J. (2003)
    394. Angiotensin II activates extracellular signal regulated kinases via protein kinase C and epidermal growth factor receptor in breast cancer cells. (PubMed id 12811831)9 Greco S....Marsigliante S. (2003)
    395. Concerted roles of SGK1 and the Na+/H+ exchanger regulatory factor 2 (NHERF2) in regulation of NHE3. (PubMed id 12649600)9 Yun C.C. (2003)
    396. Suppression of epidermal growth factor receptor, mitogen-activated protein kinase, and Pak1 pathways and invasiveness of human cutaneous squamous cancer cells by the tyrosine kinase inhibitor ZD1839 (Iressa). (PubMed id 12700278)9 Barnes C.J....Kumar R. (2003)
    397. Activation of NF-kappa B in virus-infected macrophages is dependent on mitochondrial oxidative stress and intracellular calcium: downstream involvement of the kinases TGF-beta-activated kinase 1, mitogen-activated kinase/extracellular signal-regulated kinase kinase 1, and I kappa B kinase. (PubMed id 12794154)9 Mogensen T.H....Paludan S.R. (2003)
    398. Non-specific effects of the MEK inhibitors PD098,059 and U0126 on glutamate release from hippocampal synaptosomes. (PubMed id 11750912)9 Pereira D.B....Duarte C.B. (2002)
    399. Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. (PubMed id 12391239)9 Medvedev A.E....Vogel S.N. (2002)
    400. Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling. (PubMed id 12220225)9 Paling N.R. and Welham M.J. (2002)
    401. CD40-mediated tumor necrosis factor receptor-associated factor 3 signaling upregulates IL-4-induced germline Cepsilon transcription in a human B cell line. (PubMed id 12220533)9 Basaki Y....Yanagihara Y. (2002)
    402. Inhibition of the potassium current IK(SO), in cerebellar granule cells, by the inhibitors of MEK1 activation, PD 98059 and U 0126. (PubMed id 11804618)9 Boyd D.F. and Mathie A. (2002)
    403. Proteolytic inhibition of Salmonella enterica serovar typhimurium-induced activation of the mitogen-activated protein kinases ERK and JNK in cultured human intestinal cells. (PubMed id 11748167)9 Mynott T.L....Prathalingam S.R. (2002)
    404. Suppression of Rac activity induces apoptosis of human glioma cells but not normal human astrocytes. (PubMed id 11929835)9 Senger D.L....Kaplan D.R. (2002)
    405. Molecular interpretation of ERK signal duration by immediate early gene products. (PubMed id 12134156)9 Murphy L.O....Blenis J. (2002)
    406. Transforming growth factor-beta1 transcriptionally activates CD34 and prevents induced differentiation of TF-1 cells in the absence of any cell-cycle effects. (PubMed id 11840268)9 Marone M....Pierelli L. (2002)
    407. Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells. (PubMed id 11903060)9 Tao L....August A. (2002)
    408. Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray. (PubMed id 12219026)9 Weldon C.B....Burow M.E. (2002)
    409. P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration. (PubMed id 12356872)9 Zhang H....Stromblad S. (2002)
    410. Pak1 is involved in dendrite initiation as a downstream effector of Rac1 in cortical neurons. (PubMed id 12213441)9 Hayashi K....Mikoshiba K. (2002)
    411. RISK-1: a novel MAPK homologue in axoplasm that is ac tivated and retrogradely transported after nerve injury. (PubMed id 11257614)9 Sung Y.J....Ambron R.T. (2001)
    412. P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase. (PubMed id 11549724)9 Panenka W....MacVicar B.A. (2001)
    413. C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. (PubMed id 11741534)9 Muller J....Morrison D.K. (2001)
    414. Bradykinin induced mitogenesis of androgen independent prostate cancer cells. (PubMed id 11371939)9 Barki-Harrington L. and Daaka Y. (2001)
    415. The extracellular signal-regulated protein kinases Er k1/Erk2 stimulate expression and biological activity of the transcriptional reg ulator Egr-1. (PubMed id 11530939)9 Kaufmann K....Thiel G. (2001)
    416. IRAK and TAK1 are required for IL-18-mediated signaling. (PubMed id 11745395)9 Wald D....Li X. (2001)
    417. Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1. (PubMed id 11397816)9 Sasaki Y. and Sugamura K. (2001)
    418. Vitamin E analog modulates UVB-induced signaling pathway activation and enhances cell survival. (PubMed id 11182298)9 Peus D....Pittelkow M.R. (2001)
    419. Phosphorylation of p38 mitogen-activated protein kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cells. (PubMed id 11375350)9 Nakagami H....Ogihara T. (2001)
    420. Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle. (PubMed id 11579175)9 Yu M....Zierath J.R. (2001)
    421. An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein. (PubMed id 11053419)9 Huai J. and Drescher U. (2001)
    422. Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells. (PubMed id 11382770)9 Bagheri-Yarmand R....Kumar R. (2001)
    423. Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1. (PubMed id 11278764)9 Mikosz C.A....Conzen S.D. (2001)
    424. Regulation and composition of activator protein 1 (AP-1) transcription factors controlling collagenase and c-Jun promoter activities. (PubMed id 11736649)9 SteinmA1ller L....Thiel G. (2001)
    425. The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1. (PubMed id 11416155)9 Zou X....Kiyokawa H. (2001)
    426. A dominant negative inhibitor of the Egr family of transcription regulatory factors suppresses cerebellar granule cell apoptosis by blocking c-Jun activation. (PubMed id 11487612)9 Levkovitz Y. and Baraban J.M. (2001)
    427. Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin. (PubMed id 11594781)9 Gunaje J.J. and Bhat G.J. (2001)
    428. LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505. (PubMed id 11171090)9 Amano T....Mizuno K. (2001)
    429. The coronary endothelium-derived hyperpolarizing factor (EDHF) stimulates multiple signalling pathways and proliferation in vascular cells. (PubMed id 11510882)9 Fleming I....Busse R. (2001)
    430. Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. (PubMed id 11096076)9 Ko Y.G....Kim S. (2001)
    431. IRAK1b, a novel alternative splice variant of interleukin-1 receptor- associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability. (PubMed id 11397809)9 Jensen L.E. and Whitehead A.S. (2001)
    432. Mechanical strain and estrogen activate estrogen receptor alpha in bone cells. (PubMed id 11393781)9 Jessop H.L....Lanyon L.E. (2001)
    433. Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway. (PubMed id 11087735)9 Linseman D.A....Fisher S.K. (2001)
    434. p21-activated kinase-1 (PAK1) inhibition of the human scavenger receptor class B, type I promoter in macrophages is independent of PAK1 kinase activity, but requires the GTPase-binding domain. (PubMed id 11585816)9 Hullinger T.G....Karathanasis S.K. (2001)
    435. Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene. (PubMed id 11564864)9 Yoshii S....Sugimura H. (2001)
    436. UVB-induced epidermal growth factor receptor phosphorylation is critical for downstream signaling and keratinocyte survival. (PubMed id 10911738)9 Peus D....Pittelkow M.R. (2000)
    437. Eph receptors and ephrin expression in cranial motor neurons and the branchial arches of the chick embryo. (PubMed id 10673322)9 Kury P....Guthrie S. (2000)
    438. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. (PubMed id 11062502)9 Jiang K....Djeu J.Y. (2000)
    439. Regulation of macropinocytosis by p21-activated kinase-1. (PubMed id 11029040)9 Dharmawardhane S....Bokoch G.M. (2000)
    440. Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. (PubMed id 10945974)9 Vadlamudi R.K....Kumar R. (2000)
    441. Requirement of hydrogen peroxide generation in TGF-beta 1 signal transduction in human lung fibroblast cells: involvement of hydrogen peroxide and Ca2+ in TGF-beta 1-induced IL-6 expression. (PubMed id 10925306)9 Junn E....Choi I. (2000)
    442. Dual control of muscle cell survival by distinct growth factor-regulated signaling pathways. (PubMed id 10757809)9 Lawlor M.A....Rotwein P. (2000)
    443. Peroxynitrite modulates the activation of p38 and extracellular regulated kinases in PC12 cells. (PubMed id 10775424)9 Jope R.S....Song L. (2000)
    444. p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). (PubMed id 10995762)9 King C.C....Bokoch G.M. (2000)
    445. Terminal complement complexes concomitantly stimulate proliferation and rescue of Schwann cells from apoptosis. (PubMed id 10719360)9 Dashiell S.M....Koski C.L. (2000)
    446. Salivary cellular signaling and gene regulation. (PubMed id 11842928)9 Wen X....Ann D.K. (2000)
    447. Protein kinase C regulates integrin-induced activation of the extracellular regulated kinase pathway upstream of Shc. (PubMed id 10187852)9 Miranti C.K....Brugge J.S. (1999)
    448. Activation of mitogen-activated protein kinase associated with prostate cancer progression. (PubMed id 9927031)9 Gioeli D....Weber M.J. (1999)
    449. Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade. (PubMed id 10224067)9 Zhou G....Tan T.H. (1999)
    450. Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils. (PubMed id 10496324)9 Dharmawardhane S....Bokoch G.M. (1999)
    451. Two distinct signaling pathways downstream of Janus kinase 2 play redundant roles for antiapoptotic activity of granulocyte-macrophage colony-stimulating factor. (PubMed id 10564283)9 Liu R....Watanabe S. (1999)
    452. Inhibition of myosin light chain kinase by p21-activated kinase. (PubMed id 10092231)9 Sanders Lanerolle P. (1999)
    453. A cluster of five cell wall-associated receptor kinase genes, Wak1-5, are expressed in specific organs of Arabidopsis. (PubMed id 10380805)9 He Z.H....Kohorn B.D. (1999)
    454. Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation. (PubMed id 9915804)9 Abbott D.W. and Holt J.T. (1999)
    455. MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells. (PubMed id 10085121)9 Brown J.D....Topper J.N. (1999)
    456. p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. (PubMed id 10330410)9 Sells M.A....Chernoff J. (1999)
    457. Effects of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on human small airway epithelial cells and the protective effects of myo-inositol. (PubMed id 9934861)9 Jyonouchi H....Hecht S.S. (1999)
    458. alpha-thrombin inhibits interleukin-6-induced Stat3 signaling and gp130 gene expression in primary cultures of human lung fibroblasts. (PubMed id 10080949)9 Bhat G.J....Idell S. (1999)
    459. ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling. (PubMed id 10085140)9 Sano Y....Ishii S. (1999)
    460. Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner. (PubMed id 10391889)9 Rolli M....Neininger A. (1999)
    461. H2O2 is required for UVB-induced EGF receptor and downstream signaling pathway activation. (PubMed id 10641711)9 Peus D....Pittelkow M.R. (1999)
    462. Distinct mechanisms target stress and extracellular signal-activated kinase 1 and Jun N-terminal kinase during infection of macrophages with Salmonella. (PubMed id 10528195)9 Procyk K.J....Baccarini M. (1999)
    463. An early developmental role for eph-ephrin interaction during vertebrate gastrulation. (PubMed id 10381569)9 Oates A.C....Boyd A.W. (1999)
    464. A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation. (PubMed id 9799732)9 Robinson M.J....Cobb M.H. (1998)
    465. TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism. (PubMed id 9480845)9 Sakurai H.... Sugita T. (1998)
    466. Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. (PubMed id 9774445)9 Adam L....Kumar R. (1998)
    467. Feedback regulation of Raf-1 and mitogen-activated protein kinase (MAP) kinase kinases 1 and 2 by MAP kinase phosphatase-1 (MKP-1). (PubMed id 9430728)9 Shapiro P.S. and Ahn N.G. (1998)
    468. Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production. (PubMed id 9510155)9 Dumont F.J....Camacho R. (1998)
    469. Activation of stress-activated protein kinase/c-Jun N-terminal kinase, but not NF-kappaB, by the tumor necrosis factor (TNF) receptor 1 through a TNF receptor-associated factor 2- and germinal center kinase related-dependent pathway. (PubMed id 9405407)9 Shi C.S. and Kehrl J.H. (1997)
    470. Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling. (PubMed id 8999807)9 Atfi A....Gespach C. (1997)
    471. Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains. (PubMed id 9268338)9 Zhang B....Zheng Y. (1997)
    472. Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells. (PubMed id 9298982)9 Dharmawardhane S....Bokoch G.M. (1997)
    473. Galanin, neurotensin, and phorbol esters rapidly stimulate activation of mitogen-activated protein kinase in small cell lung cancer cells. (PubMed id 8971188)9 Seufferlein T. and Rozengurt E. (1996)

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    Entrez Gene: 2042 HGNC: 3387 AceView: EPHA3 Ensembl:ENSG00000044524 euGenes: HUgn2042
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