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EPHA3 Gene

protein-coding GIFtS: 63

GC03P089239

EPH receptor A3
(Previous name: EphA3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ETK, ETK1, TYRO4)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.10.1 ^³
ETK ^², ³
ETK1 ^², ³, ⁵
EphA3 ^¹
HEK ^¹, ², ³, ⁵
HEK4 ^¹, ², ³
TYRO4 ^², ³

Descriptions
EPH receptor A3 ^²
TYRO4 protein tyrosine kinase ^²
Tyrosine-protein kinase TYRO4 ^³
Tyrosine-protein kinase receptor ETK1 ^³
eph-like tyrosine kinase 1 ^²
ephrin receptor EphA3 ^²
human embryo kinase 1 ^²

External Ids
HGNC: 3387¹
Entrez Gene: 2042²
UniProtKB: P29320³
Ensembl: ENSG00000044524⁷

Search outside databases for aliases for EPHA3 gene

Previous GC identifers: GC03P089525 GC03P092010 GC03P089036 GC03P089077

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EPHA3:

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and

EPH-related receptors have been implicated in mediating developmental events, particularly in the

nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an

extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin

receptors are divided into 2 groups based on the similarity of their extracellular domain

sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a

protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been

described for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320

Function: Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could

play a role in lymphoid function

Gene Wiki entry for EPHA3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EPHA3 gene

Entrez Gene cytogenetic band: 3p11.2 Ensembl cytogenetic band: 3p11.2 HGNC cytogenetic band: 3p11.2

EPHA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P089239: (about GC identifiers)

Start:	89,239,364 bp from pter
End:	89,613,974 bp from pter
Size:	374,611 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_022459.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320 (See protein sequence)

Recommended Name: Ephrin type-A receptor 3 precursor

Size: 983 amino acids; 110131 Da

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

PDB structures from and Proteopedia :

2GSF (3D)

2QO2 (3D)

2QO7 (3D)

2QO9 (3D)

2QOB (3D)

2QOC (3D)

2QOD (3D)

2QOF (3D)

2QOI (3D)

2QOK (3D)

2QOL (3D)

2QON (3D)

2QOO (3D)

2QOQ (3D)

3DZQ (3D)

3FXX (3D)

3FY2 (3D)

Secondary accessions: Q9H2V3 Q9H2V4

Alternative splicing: 2 isoforms: P29320-1 P29320-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_005224.2 NP_872585.1

ENSEMBL proteins:

ENSP00000337451

Human Recombinant Proteins

	Invitrogen human recombinant proteins for EPHA3
	Millipore Purified and/or Recombinant EPHA3 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Eph receptor A3, Eph receptor A2+A3+A4)
	Human Recombinant Proteins from Abnova (EPHA3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	1737782

About this table

Antibodies for EPHA3:

	Invitrogen Antibodies for EPHA3
	Millipore Mono- and Polyclonal Antibodies for the study of EPHA3
	Sigma-Aldrich Antibodies for EPHA3
	R&D Systems Antibodies for EPHA3
	Cell Signaling Technology (CST) Antibodies for EPHA3
	Antibodies from Abcam (Eph receptor A3, Eph receptor A2+A3+A4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EPHA3)
	Novus Biologicals Antibodies for EPHA3

Assays for EPHA3:

	Invitrogen Assays for EPHA3
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P29320

ProtoNet protein and cluster: P29320

5/6 Blocks protein families (see all 6 ):

IPB001090 Ephrin receptor

IPB001426 Receptor tyrosine kinase

IPB001660 Sterile alpha motif SAM

IPB003962 Fibronectin type III repeat signature

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor

subfamily

Similarity: Contains 2 fibronectin type-III domains

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EPHA3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EPHA3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_182644

Applied Biosystems Silencer® siRNAs for EPHA3

Sigma-Aldrich siRNA and siRNA Panels for EPHA3

Sigma-Aldrich shRNA Panels and shRNA for EPHA3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005233
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005233
untagged cDNA clones in CMV expression vector (see all 3): NM_005233

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005233

UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320

Function: Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could

play a role in lymphoid function

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.1

Genatlas biochemistry entry for EPHA3:

EPH-related tyrosine kinase receptor binding ephrins A,expressed in projecting neurons and their

target fields,involved in short-range contact-mediated axonal guidance,expressed by some pre-B and

T cell lines,not detectable on normal adult human tissues

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Epha3):

behavior/neurological

homeostasis/metabolism

lethality-prenatal/perinatal

respiratory system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0005003	ephrin receptor activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for EPHA3 (Your Favorite Gene powered by Ingenuity)

Ephrin Receptor Signaling
Axonal Guidance Signaling

GeneDecks EPHA3 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for EPHA3

5/35 Interacting proteins for EPHA3 (ENSP00000337451³) via UniProtKB, MINT, and/or STRING (see all 35 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EFNA5	ENSP00000328777³	STRING (score=.999)
EFNA1	ENSP00000357392³	STRING (score=.997)
EFNA2	ENSP00000215368³	STRING (score=.994)
EFNA3	ENSP00000357393³	STRING (score=.986)
CRK	ENSP00000300574³	STRING (score=.983)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0007165	signal transduction	TAS	1737782
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EPHA3
10/30 Novoseek chemical compound relationships for EPHA3 gene (see all 30 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tab-1	71.86	3	11745395 (1), 17052891 (1), 17932218 (1)
threonine	62.43	19	16641196 (1), 9405407 (1), 17000703 (1), 16895519 (1) (see all 18)
pd 98,059	61.70	10	18778461 (1), 10925306 (1), 12628005 (1), 14690534 (1) (see all 9)
tyrosine	56.35	18	1334998 (2), 8188238 (2), 15151996 (1), 18762249 (1) (see all 15)
cl 100	53.95	1	15030167 (1)
phosphatidylinositol	50.89	5	14633175 (1), 16322251 (1), 11382770 (1), 12589827 (1) (see all 5)
phosphoinositide	47.17	7	15468165 (1), 16885398 (1), 16895519 (1), 19025518 (1) (see all 7)
wortmannin	38.35	3	15468165 (1), 9934861 (1), 12589827 (1)
17-(allylamino)-17-demethoxygeldanamycin	37.78	1	17308059 (1)
sp 600125	35.84	3	18778461 (1), 15670787 (1), 12589827 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EPHA3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EPHA3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_182644

Sigma-Aldrich siRNA and siRNA Panels for EPHA3

Sigma-Aldrich shRNA Panels and shRNA for EPHA3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005233 NM_182644

REFSEQ mRNAs for EPHA3 gene (2 alternative transcripts):

NM_005233.5 NM_182644.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005233 NM_182644

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005233
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005233
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_005233

Additional cDNA sequence:

AF213459.1 AF213460.1 AK024352.1 AK291411.1 BC026247.1 BC063282.1 M83941.1

4 DOTS entries:

DT.97837000 DT.208723 DT.40125530 DT.100662313

24/45 AceView cDNA sequences (see all 45 ):

BE327884 NM_182644 BC063282 AF213460 AL042479 AU120483 NM_005233 AK024352

BC026247 T28603 AF213459 AU137594 AI741389 AI918950 BG033947 AI590014

D81814 BM927323 AU136712 BQ003325 BQ026760 AI824661 M85652 AA525961

highest scoring ESTs for EPHA3:

M83941 AA424266 AA452194 AA916335 AI741389 AK024352 AL039343 AU120483 AU137594 AV723897

Unigene Cluster for EPHA3:

EPH receptor A3

Hs.123642 [show with all ESTs]

Unigene Representative Sequence: NM_005233

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000336596

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EPHA3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EPHA3

¹ / ² / ³

8 probe-sets matching EPHA3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1234_at²^{, 3}	U95-A	1	1.00	1.00	0.61	0.53	M83941	1.00	1.00	1.00	1
58771_at²^{, 3}	U95-B	1	1.00	1.00	0.89	1.53	AA916335	0.80	1.00	0.91	1
206071_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005233	0.60	1.00	0.82	1
206070_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF213459	0.60	1.00	0.82	1
211164_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF213460	0.60	1.00	0.82	1
206071_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206070_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211164_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks EPHA3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.123642
Expression variation in blood from EXPOLDB for EPHA3
UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320
Tissue specificity: Widely expressed. Highest level in placenta

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EPHA3 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EPHA3¹	--	EPH receptor A3	88.46(n) 96.27(a)	487930 XM_545052.2 XP_545052.2
chimpanzee (Pan troglodytes)	EPHA3¹	--	EPH receptor A3	99.02(n) 98.78(a)	460531 XM_001136396.1 XP_001136396.1
cow (Bos taurus)	EPHA3¹	--	EPH receptor A3	92.71(n) 97.46(a)	537951 XM_618140.3 XP_618140.3
rat (Rattus norvegicus)	Epha3¹	--	Eph receptor A3	89.56(n) 95.73(a)	29210 NM_031564.1 NP_113752.1
mouse (Mus musculus)	Epha3^{1, 5}	16⁵	Eph receptor A3^{1, 5}	88.84(n)¹ 96.54(a)¹	13837¹ NM_010140.2¹ NP_034270.1¹ AK044936⁵ AK045219⁵ (see all 18)

About this table Species with no ortholog for EPHA3

ENSEMBL Gene Tree for EPHA3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EPHA3 gene

EPHA5² EPHA6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1478 NCBI SNPs in EPHA3 are shown (see all 1478 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 436)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7650466^1,2	A,C,F,H	89613048(+)	`CAAAAC/TTCACA`	1	--	ut3¹ ese³		7	EU EA WA NA	558
	rs13074291^1,2	A,C,F,H	89239209(+)	`TAAAAC/TAGCTA`	2	--	ng5¹ tfbs³		4	EU EA WA	418
	rs7650184^1,2	A,F,H	89612747(+)	`AGCAAC/ACGCCT`	1	--	ut3¹		3	EU EA	272
	rs3762717^1,2	C,F,H	89611638(+)	`GATCAT/CAAACT`	1	--	ut3¹		7	NA EU EA WA	560
	rs17801309^1,2	C,F,H	89604354(+)	`CTTCCG/ACACAA`	1	H/R	mis¹ ese³		15	NA EU EA WA	1400
	rs35124509^1,2	C,F,H	89604383(+)	`GTGTCC/TGGACA`	1	W/R	mis¹		8	EU EA WA	840
	rs2117138^1,2	A,C,F	89614212(+)	`AATAGA/GCAGTT`	1	--	ng3¹		3	NA	140
	rs7432102^1,2	C,H	89238640(+)	`AGGAGC/TTGTGA`	2	--	ng5¹		4	EU EA WA	420
	rs13074375^1,2	A,H	89239382(+)	`AGCGCA/GCGCTG`	2	--	ut5¹ ese³		4	EU EA WA	418
	rs34437982^1,2	C	89563183(+)	`AGAAGC/GTGCTT`	1	A/G	mis¹		4	EU EA WA	420

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HapMap Linkage Disequilibrium images for EPHA3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 179611

UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320

Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500]

10/23 Novoseek disease relationships for EPHA3 gene (see all 23 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
parkinson disease	43.39	13	16672981 (1), 17000703 (1), 17707122 (1), 17362513 (1) (see all 12)
breast cancer	34.92	14	12151336 (2), 18392133 (2), 16322251 (1), 18650427 (1) (see all 12)
parkinsonism	33.82	9	16226715 (1), 19279012 (1), 17084972 (1), 17620882 (1) (see all 9)
neurodegenerative diseases	28.60	1	18334630 (1)
tumors	25.93	20	10498621 (2), 10987298 (2), 15688034 (1), 16778166 (1) (see all 17)
cancer	25.42	7	14760089 (1), 17611497 (1), 12560069 (1), 14530270 (1) (see all 7)
cardiac hypertrophy	14.04	1	18054038 (1)
uveal melanoma	10.22	1	16845324 (1)
necrosis	6.29	3	15523691 (1), 19298660 (1), 12889600 (1)
retinoblastoma	3.96	1	12889598 (1)

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Human Genome Epidemiology Navigator: EPHA3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/414 PubMed articles for EPHA3 gene (see all 414 ):

Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines. (PubMed id 1311845)^{2, 3, 4} Wicks I.P....Boyd A.W. (1992)
Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line. (PubMed id 1737782)^{2, 3, 4} Boyd A.W.... Busmanis I. (1992)
Identification of a tumor-specific shared antigen derived from an Eph receptor and presented to CD4 T cells on HLA class II molecules. (PubMed id 10987298)^{1, 3, 4} Chiari R....Coulie P.G. (2000)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{3, 4} Hillman R.T.... Brenner S.E. (2004)
The EphA3 receptor is expressed in a subset of rhabdomyosarcoma cell lines and suppresses cell adhesion and migration. (PubMed id 18814179)^{1, 3} Clifford N....O'Connor R. (2008)
EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion. (PubMed id 14697337)^{1, 3} Smith L.M....O'Connor R. (2004)
Localization of a human receptor tyrosine kinase (ETK1) to chromosome region 3p11.2. (PubMed id 8188238)^{1, 3} Wicks I.P....Sutherland G.R. (1994)
Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3). (PubMed id 18547520)^{1, 3} Davis T.L....Dhe-Paganon S. (2008)
Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro. (PubMed id 9751130)^{1, 3} Ciossek T....Drescher U. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2042	HGNC: 3387	AceView: EPHA3	Ensembl:ENSG00000044524	euGenes: HUgn2042
ECgene: EPHA3	H-InvDB: EPHA3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for EPHA3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for EPHA3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for EPHA3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EPHA3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EPHA3		Antibodies for EPHA3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for EPHA3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (EPHA3)
	Antibodies (EPHA3)
	Chimera RNAi (EPHA3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for EPHA3

	Recombinant Proteins (Eph receptor A3, Eph receptor A2+A3+A4)
	Antibodies (Eph receptor A3, Eph receptor A2+A3+A4)

Search OriGene for EPHA3

Search Tocris compounds for EPHA3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for EPHA3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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EPHA3 Gene at Home site.
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EPHA3 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for EPHA3

Summaries
for EPHA3

Genomic Location
for EPHA3

Proteins
for EPHA3

Protein Domains/
Families
for EPHA3

Gene Function
for EPHA3

Pathways & Interactions
for EPHA3

Drugs & Compounds
for EPHA3

Transcripts
for EPHA3

Expression
for EPHA3

Orthologs
for EPHA3

Paralogs
for EPHA3

SNPs/Variants
for EPHA3

Disorders & Mutations
for EPHA3

Medical News
for EPHA3

Publications
for EPHA3

Search for EPHA3

Genome Databases showing EPHA3

Other Databases showing EPHA3

Specialized Databases showing EPHA3

Licensable Technologies
for EPHA3

Services
for EPHA3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EPHA3 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor EPHA3

Summariesfor EPHA3

Genomic Locationfor EPHA3

Proteinsfor EPHA3

Protein Domains/Familiesfor EPHA3

Gene Functionfor EPHA3

Pathways & Interactionsfor EPHA3

Drugs & Compoundsfor EPHA3

Transcriptsfor EPHA3

Expression for EPHA3

Orthologsfor EPHA3

Paralogsfor EPHA3

SNPs/Variantsfor EPHA3

Disorders & Mutationsfor EPHA3

Medical Newsfor EPHA3

Publicationsfor EPHA3

Search for EPHA3

Genome Databases showing EPHA3

Other Databases showing EPHA3

Specialized Databases showing EPHA3

Licensable Technologiesfor EPHA3

Servicesfor EPHA3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EPHA3

Summaries
for EPHA3

Genomic Location
for EPHA3

Proteins
for EPHA3

Protein Domains/
Families
for EPHA3

Gene Function
for EPHA3

Pathways & Interactions
for EPHA3

Drugs & Compounds
for EPHA3

Transcripts
for EPHA3

Expression
for EPHA3

Orthologs
for EPHA3

Paralogs
for EPHA3

SNPs/Variants
for EPHA3

Disorders & Mutations
for EPHA3

Medical News
for EPHA3

Publications
for EPHA3

Licensable Technologies
for EPHA3

Services
for EPHA3