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EPHA2 Gene

protein-coding   GIFtS: 75
GCID: GC01M016450

EPH Receptor A2

(Previous name: EphA2)
(Previous symbol: ECK)
  See EPHA2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
EPH Receptor A21 2     CTRCT62 5
ECK1 2 3 5     EphA21
Tyrosine-Protein Kinase Receptor ECK2 3     Ephrin Type-A Receptor 22
EC 2.7.10.13 8     Epithelial Cell Receptor Protein Tyrosine Kinase2
ARCC22 5     Soluble EPHA2 Variant 12
CTPA2 5     Epithelial Cell Kinase3
CTPP12 5     EC 2.7.108

External Ids:    HGNC: 33861   Entrez Gene: 19692   Ensembl: ENSG000001426277   OMIM: 1769465   UniProtKB: P293173   

Export aliases for EPHA2 gene to outside databases

Previous GC identifers: GC01M015783 GC01M015564 GC01M015679 GC01M015831 GC01M016196 GC01M016323 GC01M014968


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EPHA2 Gene:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related
receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors
in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich
domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity
of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene
encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain
genetically-related cataract disorders.(provided by RefSeq, May 2010)

GeneCards Summary for EPHA2 Gene:
EPHA2 (EPH receptor A2) is a protein-coding gene. Diseases associated with EPHA2 include cataract 6, multiple types, and cataract, age-related cortical, 2. GO annotations related to this gene include ephrin receptor activity and transmembrane receptor protein tyrosine kinase activity. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHA2_HUMAN, P29317
Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates
migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and
differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling
pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect
on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and
subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain
development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by
the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens
transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through
regulation of osteoclastogenesis and osteoblastogenesis

Gene Wiki entry for EPHA2 (EPH receptor A2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EPHA2 gene promoter:
         Elk-1   MAZR   RelA   CUTL1   STAT5A   E47   CREB   Ik-2   deltaCREB   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for EPHA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36

EPHA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHA2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M016450:  view genomic region     (about GC identifiers)

Start:
16,450,832 bp from pter      End:
16,482,582 bp from pter
Size:
31,751 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EPHA2_HUMAN, P29317 (See protein sequence)
Recommended Name: Ephrin type-A receptor 2 precursor  
Size: 976 amino acids; 108266 Da
Subunit: Homodimer. Interacts with SLA. Interacts (phosphorylated form) with VAV2, VAV3 and PI3-kinase p85 subunit
(PIK3R1, PIK3R2 or PIK3R3); critical for the EFNA1-induced activation of RAC1 which stimulates cell migration (By
similarity). Interacts with INPPL1; regulates activated EPHA2 endocytosis and degradation. Interacts (inactivated
form) with PTK2/FAK1 and interacts (EFNA1 ligand-activated form) with PTPN11; regulates integrin-mediated
adhesion. Interacts with ARHGEF16, DOCK4 and ELMO2; mediates ligand-independent activation of RAC1 which
stimulates cell migration. Interacts with CLDN4; phosphorylates CLDN4 and may regulate tight junctions. Interacts
with ACP1. Interacts (via SAM domain) with ANKS1A (via SAM domain). Interacts with human herpes virus 8/HHV-8
glycoprotein L/gL and glycoprotein H/gH heterodimer; this interaction triggers EPHA2 phosphorylation and
endocytosis, allowing virus entry
Selected PDB 3D structures from and Proteopedia for EPHA2 (see all 15):
1MQB (3D)        2E8N (3D)        2K9Y (3D)        2KSO (3D)        2X10 (3D)        2X11 (3D)    
Secondary accessions: Q8N3Z2

Explore the universe of human proteins at neXtProt for EPHA2: NX_P29317

Explore proteomics data for EPHA2 at MOPED

Post-translational modifications: 

  • Autophosphorylates. Phosphorylated on tyrosine upon binding and activation by EFNA1. Phosphorylated residues
    Tyr-588 and Tyr-594 are required for binding VAV2 and VAV3 while phosphorylated residues Tyr-735 and Tyr-930 are
    required for binding PI3-kinase p85 subunit (PIK3R1, PIK3R2 or PIK3R3). These phosphorylated residues are
    critical for recruitment of VAV2 and VAV3 and PI3-kinase p85 subunit which transduce downstream signaling to
    activate RAC1 GTPase and cell migration (By similarity). Phosphorylated at Ser-897 by PKB; serum-induced
    phosphorylation which targets EPHA2 to the cell leading edge and stimulates cell migration. Phosphorylation by
    PKB is inhibited by EFNA1-activated EPHA2 which regulates PKB activity via a reciprocal regulatory loop.
    Dephosphorylated by ACP11
  • Ubiquitinated by CHIP/STUB1. Ubiquitination is regulated by the HSP90 chaperone and regulates the receptor
    stability and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation (By
    similarity)1
  • Ubiquitination2 at Lys578
  • Glycosylation2 at Asn407, Asn435
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for EPHA2 (P29317) (see all 20)
     RDLAARN  NWLRTNW  CKETFNL  QLVGMLRG 


    See EPHA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004422.2  
    ENSEMBL proteins: 
     ENSP00000351209  

    EPHA2 Human Recombinant Protein Products:

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    Novus Biologicals EPHA2 Proteins
    Novus Biologicals EPHA2 Lysates
    Browse Sino Biological Recombinant Proteins
    Sino Biological Cell Lysate for EPHA2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EPHA2

     
    Search eBioscience for Proteins for EPHA2 

    EPHA2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of EPHA2
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    Abcam antibodies for EPHA2 (P54764, P29317)
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    ThermoFisher Antibodies for EPHA2
    LSBio Antibodies in human, mouse, rat for EPHA2

    EPHA2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for EPHA2         (see all)
    GenScript EPHA2-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EPHA2
    Cloud-Clone Corp. CLIAs for EPHA2
    Search eBioscience for ELISAs for EPHA2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor A2
    Ephrin receptor family
    Ephrin receptor family

    Selected InterPro protein domains (see all 17):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR021129 SAM_type1
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P29317

    ProtoNet protein and cluster: P29317

    4 Blocks protein domains:
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHA2_HUMAN, P29317
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with EPHA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHA2_HUMAN, P29317
    Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates
    migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and
    differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling
    pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect
    on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and
    subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain
    development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by
    the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens
    transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through
    regulation of osteoclastogenesis and osteoblastogenesis
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Induction: Up-regulated by UV irradiation via a TP53-independent, MAPK-dependent mechanism

         Genatlas biochemistry entry for EPHA2:
    EPH related tyrosine kinase receptor,binding ephrins A,expressed in projecting neurons and their target
    fields,involved in short-range contact-mediated axonal guidance,highly expressed in metastatic melanoma cells

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity IDA10655584
    GO:0005003ephrin receptor activity IEA--
    GO:0005515protein binding IPI10655584
         
    Find genes that share ontologies with EPHA2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for EPHA2:
     Increased cell death in HCC-19  Increased mitotic index 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Epha2):
     cardiovascular system  embryogenesis  homeostasis/metabolism  limbs/digits/tail  nervous system 
     normal  skeleton  tumorigenesis  vision/eye 

    Find genes that share phenotypes with EPHA2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Epha2tm1Jrui for EPHA2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EPHA2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EPHA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPHA2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPHA2

    miRNA
    Products:
        
    miRTarBase miRNAs that target EPHA2:
    hsa-mir-34a-5p (MIRT025420), hsa-mir-26b-5p (MIRT005508), hsa-mir-193b-3p (MIRT016375), hsa-mir-940 (MIRT036589), hsa-mir-16-5p (MIRT031603)

    Block miRNA regulation of human, mouse, rat EPHA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EPHA2 (see all 35):
    hsa-miR-520e hsa-miR-302d hsa-miR-548k hsa-miR-200a hsa-miR-519a hsa-miR-141 hsa-miR-124 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidEPHA2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for EPHA2
    Predesigned siRNA for gene silencing in human, mouse, rat EPHA2

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for EPHA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EPHA2 (NM_004431)
    Sino Biological Human cDNA Clone for EPHA2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA2
    Addgene plasmids for EPHA2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EPHA2_HUMAN, P29317: Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane;
    Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane
    protein. Cell junction, focal adhesion. Note=Present at regions of cell-cell contacts but also at the leading
    edge of migrating cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    cytosol2
    extracellular2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA18794797
    GO:0005887integral component of plasma membrane IDA10655584
    GO:0005925focal adhesion IDA10655584
    GO:0031256leading edge membrane IDA19573808
    GO:0031258lamellipodium membrane IEA--

    Find genes that share ontologies with EPHA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EPHA2 About   (see all 26)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71


    Find genes that share SuperPaths with EPHA2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EPHA2 (see all 32)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    P2Y Receptor Signaling

    2 Cell Signaling Technology (CST) Pathways for EPHA2
        Angiogenesis
    Tyrosine Kinases / Adaptors

    3 GeneGo (Thomson Reuters) Pathways for EPHA2
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    Selected BioSystems Pathways for EPHA2 (see all 6)
        Direct p53 effectors
    EPHA2 forward signaling
    Arf6 signaling events
    EPHA forward signaling
    Stabilization and expansion of the E-cadherin adherens junction



    4 Kegg Pathways  (Kegg details for EPHA2):
        Ras signaling pathway
    Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EPHA2
    Interactions:

        GeneGlobe Interaction Network for EPHA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EPHA2 (P293171, 2, 3 ENSP000003512094) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFNA1P208271, 2, 3, ENSP000003573924EBI-702104,EBI-715194 MINT-7218724 MINT-7218694 I2D: score=4 STRING: ENSP00000357392
    PTK2Q053971, 3, ENSP000003411894EBI-702104,EBI-702142 I2D: score=2 STRING: ENSP00000341189
    EFNA3P527973, ENSP000003573934I2D: score=3 STRING: ENSP00000357393
    PTPN11Q061243, ENSP000003409444I2D: score=3 STRING: ENSP00000340944
    SHC1P293533, ENSP000004013034I2D: score=3 STRING: ENSP00000401303
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IEA--
    GO:0001525angiogenesis IEA--
    GO:0001568blood vessel development ----
    GO:0001570vasculogenesis IEA--
    GO:0001649osteoblast differentiation ISS--

    Find genes that share ontologies with EPHA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EPHA2

    2 HMDB Compounds for EPHA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    3 DrugBank Compounds for EPHA2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dasatinib-- 302962-49-8targetantagonist17139284 20072833 17016423
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--17139284 17016423
    Regorafenib-- 755037-03-7targetinhibitor--

    6 Novoseek inferred chemical compound relationships for EPHA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 76.6 81 18387945 (4), 11309274 (4), 16426859 (3), 10511313 (2) (see all 54)
    vegf 16.7 15 18485799 (8), 17767065 (4), 17680030 (2), 15579670 (1)
    phosphoinositide 14.2 3 17135240 (1), 20028874 (1)
    phosphotyrosine 12.6 2 10511313 (1)
    agar 0 4 12019162 (2), 15359289 (1)
    estrogen 0 8 12810680 (4), 11968011 (2), 19396818 (1)



    Find genes that share compounds with EPHA2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EPHA2 gene: 
    NM_004431.3  

    Unigene Cluster for EPHA2:

    EPH receptor A2
    Hs.171596  [show with all ESTs]
    Unigene Representative Sequence: NM_004431
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358432(uc001aya.2 uc010oca.2) ENST00000462805 ENST00000480202
    ENST00000461614
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate EPHA2 (see all 35):
    hsa-miR-520e hsa-miR-302d hsa-miR-548k hsa-miR-200a hsa-miR-519a hsa-miR-141 hsa-miR-124 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidEPHA2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK296788.1 BC008655.1 BC037166.2 EU826606.1 M59371.1 

    7 DOTS entries:

    DT.447452  DT.99979334  DT.100044652  DT.100776917  DT.91853271  DT.95223102  DT.95312785 

    Selected AceView cDNA sequences (see all 215):

    BQ680319 AA513018 BQ883580 BM127056 BQ890666 BU685241 AA513011 BU684699 
    AI688108 BQ100980 BU173612 BQ688608 AL138105 CD674959 BF062514 BM783663 
    CK823047 AI139852 NM_004431 CD110234 BF000238 AA534802 BC037166 BQ101148 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EPHA2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18
    SP1:                                                                                                                                                
    SP2:                                                                                                                                                
    SP3:                                                                                                                                                
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for EPHA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EPHA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCAGTCGG
    EPHA2 Expression
    About this image


    EPHA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Early Floor Plate Cells Mesencephalic Floor Plate
             Thalamus
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 5 entries
             Line H9 (Naive)
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Late Floor Plate Cells Mesencephalic Floor Plate
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
    EPHA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EPHA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.171596

    UniProtKB/Swiss-Prot: EPHA2_HUMAN, P29317
    Tissue specificity: Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most
    highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung, and ovary

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for EPHA2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Epha21 , 5 Eph receptor A21, 5 86.63(n)1
    93.03(a)1
      4 (73.67 cM)5
    138361  NM_010139.31  NP_034269.21 
     1413012405 
    chicken
    (Gallus gallus)
    Aves EPHA21 EPH receptor A2 75.94(n)
    75.56(a)
      771550  XM_001234813.3  XP_001234814.2 
    lizard
    (Anolis carolinensis)
    Reptilia EPHA26
    EPH receptor A2
    72(a)
    1 ↔ 1
    GL344107.1(14116-45452)
    African clawed frog
    (Xenopus laevis)
    Amphibia epha2-A2 ephrin receptor EphA2 (tyrosine kinase family) 77.39(n)    BC060745.1 
    zebrafish
    (Danio rerio)
    Actinopterygii EPHA2 (2 of 2)6
    epha2a6
    eph receptor A2 a
    59(a)
    55(a)
    1 ↔ many
    1 ↔ many
    23(24634982-24682058) ENSDARG00000022727
    6(45811779-45842930) ENSDARG00000017354
    fruit fly
    (Drosophila melanogaster)
    Insecta hop3 JAK-STAT cascade protein tyrosine
    kinase
    41(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for EPHA2 (if available)
    TreeFam Gene Tree for EPHA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EPHA2 gene
    EPHB12  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHA12  EPHB22  
    EPHA82  EPHA32  EPHA72  EPHA102  EPHB42  
    Selected SIMAP similar genes for EPHA2 using alignment to 4 protein entries:     EPHA2_HUMAN (see all proteins) (see all similar genes):
    EPHA6    EPHB2 variant protein    EPHA4    EPHA7    EPHA3    EPHB3
    EPHB1    BTK kinase deficient isoform 2    HCK    EPHA5    FES    FYN
    FER    MET    TXK    EPHB2    LYN    NTRK2

    Find genes that share paralogs with EPHA2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EPHA2 (see all 849)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1165066141,2,,4
    C,FCataract 6, multiple types (CTRCT6)4 pathogenic116356419(+) TGCCCC/TGCAGC 2 Q R mis12Minor allele frequency- T:0.00NA EU 5875
    VAR_0589084
    Cataract 6, multiple types (CTRCT6)4--see VAR_0589082 G W mis40--------
    VAR_0421244
    A gastric adenocarcinoma sample4--see VAR_0421242 G S mis40--------
    VAR_0589074
    Cataract 6, multiple types (CTRCT6)4--see VAR_0589072 T I mis40--------
    rs1440755621,2
    Cuntested116359938(+) GGCCCA/C/TCCAGC 2 E G mis11NA 4340
    rs339578541,2
    C--14978660(+) TTAAT-/AACAACAA 2 -- int1 cds10--------
    rs1476591281,2
    C--14978661(+) TTAAT-/AACAACAA 1 -- int10--------
    rs341987141,2
    C--14978663(+) AACAA-/CAAGAGCA 1 -- int13Minor allele frequency- CAA:0.00NA CSA 8
    rs747710211,2
    C--14978663(+) AATAAC/TAACAA 1 -- int10--------
    rs357378691,2
    C--14997197(+) GGGGG-/AAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for EPHA2 (16450832 - 16482582 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EPHA2 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508936CNV Insertion20534489
    nsv470699CNV Loss18288195
    dgv174n71CNV Loss21882294
    nsv871485CNV Loss21882294
    nsv871825CNV Loss21882294
    nsv833869CNV Loss17160897
    nsv524045CNV Loss19592680
    dgv177n71CNV Loss21882294
    nsv870978CNV Loss21882294
    nsv520148CNV Loss19592680

    Human Gene Mutation Database (HGMD): EPHA2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EPHA2
    DNA2.0 Custom Variant and Variant Library Synthesis for EPHA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176946   
    OMIM disorders: 116600  
    UniProtKB/Swiss-Prot: EPHA2_HUMAN, P29317
  • Cataract 6, multiple types (CTRCT6) [MIM:116600]: An opacification of the crystalline lens of the eye
    that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a
    portion of the lens, and may be static or progressive. CTRCT6 includes posterior polar and age-related cortical
    cataracts, among others. Posterior polar cataract is a subcapsular opacity, usually disk-shaped, located at the
    back of the lens. Age-related cortical cataract is a developmental punctate opacity restricted to the cortex. The
    cataract is white or cerulean, increases in number with age, but rarely affects vision. Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • Note=Overexpressed in several cancer types and promotes malignancy

  • 5 diseases for EPHA2:    
    About MalaCards
    cataract 6, multiple types    cataract, age-related cortical, 2    brain stem glioma    cataract 20, multiple types
    cataract

    1 disease from the University of Copenhagen DISEASES database for EPHA2:
    Leukemia

    Find genes that share disorders with EPHA2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for EPHA2 gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mimicry 60.2 6 12941789 (1), 11309274 (1), 16481735 (1), 19223760 (1) (see all 6)
    tumors 54.1 208 11146556 (6), 16533422 (6), 16849550 (6), 19484140 (5) (see all 62)
    cancer 49.9 78 19948216 (5), 17374733 (3), 19690146 (3), 14767510 (3) (see all 35)
    metastatic melanoma 48 4 14679012 (1), 11309274 (1)
    ovarian cancer 45.3 19 16300469 (3), 18443431 (3), 17154180 (3), 16969087 (2) (see all 10)
    metastasis 42.8 48 19264906 (4), 14767510 (3), 19788698 (3), 19934338 (3) (see all 19)
    melanoma 42.4 24 19223760 (6), 7780963 (5), 16481735 (2), 12941789 (1) (see all 8)
    glioma 42.4 16 18614215 (4), 16207473 (3), 17332925 (3), 18324354 (1) (see all 7)
    ovarian carcinoma 39.9 12 15297418 (4), 16061279 (3), 19395869 (2), 16969087 (1) (see all 5)
    glioblastoma multiforme 34.2 5 16254188 (2), 16207473 (1), 18097589 (1), 18172271 (1)

    Genetic Association Database (GAD): EPHA2
    Human Genome Epidemiology (HuGE) Navigator: EPHA2 (2 documents)

    Export disorders for EPHA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EPHA2 gene, integrated from 10 sources (see all 281):
    (articles sorted by number of sources associating them with EPHA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The EPHA2 gene is associated with cataracts linked to chromosome 1p. (PubMed id 19005574)1, 2, 4 Shiels A....Hejtmancik J.F. (Mol. Vis. 2008)
    2. EphA2 is an essential mediator of UV radiation-induced apoptosis. (PubMed id 18339848)1, 2, 9 Zhang G.... Tsao H. (Cancer Res. 2008)
    3. EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. (PubMed id 19573808)1, 2, 9 Miao H....Wang B. (Cancer Cell 2009)
    4. EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability. (PubMed id 16236711)1, 2, 9 Tanaka M.... Sakai R. (J. Biol. Chem. 2005)
    5. Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK. (PubMed id 17332925)1, 2, 9 Liu D.-P.... Xie D. (Int. J. Oncol. 2007)
    6. Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography. (PubMed id 12467573)1, 2, 9 Nowakowski J....Thompson D.A. (Structure 2002)
    7. cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. (PubMed id 2174105)1, 2, 9 Lindberg R.A. and Hunter T. (Mol. Cell. Biol. 1990)
    8. Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation. (PubMed id 12167657)1, 2, 9 Kikawa K.D.... Kinch M.S. (J. Biol. Chem. 2002)
    9. Human cataract mutations in EPHA2 SAM domain alter receptor stability and function. (PubMed id 22570727)1, 2 Park J.E.... Zhou R. (PLoS ONE 2012)
    10. Solution structure of the first Sam domain of Odin and binding studies with the EphA2 receptor. (PubMed id 22332920)1, 2 Mercurio F.A....Leone M. (Biochemistry 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1969 HGNC: 3386 AceView: EPHA2 Ensembl:ENSG00000142627 euGenes: HUgn1969
    ECgene: EPHA2 Kegg: 1969 H-InvDB: EPHA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EPHA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHA2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EPHA2 gene:
    Search GeneIP for patents involving EPHA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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