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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EPHA2 Gene

protein-coding   GIFtS: 71
GCID: GC01M016450

EPH receptor A2

(Previous name: EphA2 )
(Previous symbol: ECK)
 Explore 53 diseases affiliated with
EPHA2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for EPHA2    

Aliases
for EPHA2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
EPH Receptor A21 2     CTPP12
ECK1 2 3 5     Ephrin Type-A Receptor 22
Tyrosine-Protein Kinase Receptor ECK2 3     Epithelial Cell Receptor Protein Tyrosine Kinase2
EC 2.7.10.13 8     Soluble EPHA2 Variant 12
ARCC22 5     Epithelial Cell Kinase3
EphA21     EC 2.7.108
CTPA2     

External Ids:    HGNC: 33861   Entrez Gene: 19692   Ensembl: ENSG000001426277   OMIM: 1769465   UniProtKB: P293173   

Export aliases for EPHA2 gene to outside databases

Previous GC identifers: GC01M015783 GC01M015564 GC01M015679 GC01M015831 GC01M016196 GC01M016323 GC01M014968


Summaries
for EPHA2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EPHA2:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors
have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH
subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2
fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their
extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a
protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract
disorders.(provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: EPHA2_HUMAN, P29317
Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway
downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin
ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration,
integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation
through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also
participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell
migration. During development, may function in distinctive aspects of pattern formation and subsequently in
development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and
epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand
ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency
development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of
osteoclastogenesis and osteoblastogenesis

Gene Wiki entry for EPHA2 (EPH receptor A2)


Genomic Views
for EPHA2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EPHA2 gene promoter:
         Elk-1   MAZR   RelA   CUTL1   STAT5A   E47   CREB   Ik-2   deltaCREB   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for EPHA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36

EPHA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHA2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M016450:  view genomic region     (about GC identifiers)

Start:
 16,450,832 bp from pter      End:
 16,482,582 bp from pter
Size:
 31,751 bases      Orientation:
 minus strand

Proteins
for EPHA2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EPHA2_HUMAN, P29317 (See protein sequence)
Recommended Name: Ephrin type-A receptor 2 precursor  
Size: 976 amino acids; 108266 Da
Subunit: Homodimer. Interacts with SLA. Interacts (phosphorylated form) with VAV2, VAV3 and PI3-kinase p85 subunit
(PIK3R1, PIK3R2 or PIK3R3); critical for the EFNA1-induced activation of RAC1 which stimulates cell migration.
Interacts with ANKS1A (By similarity). Interacts with INPPL1; regulates activated EPHA2 endocytosis and degradation.
Interacts (inactivated form) with PTK2/FAK1 and interacts (EFNA1 ligand-activated form) with PTPN11; regulates
integrin-mediated adhesion. Interacts with ARHGEF16, DOCK4 and ELMO2; mediates ligand-independent activation of RAC1
which stimulates cell migration. Interacts with CLDN4; phosphorylates CLDN4 and may regulate tight junctions.
Interacts with ACP1
Subcellular location: Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass
type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell junction,
focal adhesion. Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells
6/15 PDB 3D structures from and Proteopedia for EPHA2 (see all 15):
1MQB (3D)        2E8N (3D)        2K9Y (3D)        2KSO (3D)        2X10 (3D)        2X11 (3D)    
Secondary accessions: Q8N3Z2

Explore the universe of human proteins at neXtProt for EPHA2: NX_P29317

Post-translational modifications:

  • Autophosphorylates. Phosphorylated on tyrosine upon binding and activation by EFNA1. Phosphorylated residues Tyr-588
    • and Tyr-594 are required for binding VAV2 and VAV3 while phosphorylated residues Tyr-735 and Tyr-930 are required for
    binding PI3-kinase p85 subunit (PIK3R1, PIK3R2 or PIK3R3). These phosphorylated residues are critical for recruitment
    of VAV2 and VAV3 and PI3-kinase p85 subunit which transduce downstream signaling to activate RAC1 GTPase and cell
    migration (By similarity). Phosphorylated at Ser-897 by PKB; serum-induced phosphorylation which targets EPHA2 to the
    cell leading edge and stimulates cell migration. Phosphorylation by PKB is inhibited by EFNA1-activated EPHA2 which
    regulates PKB activity via a reciprocal regulatory loop. Dephosphorylated by ACP11
  • Ubiquitinated by CHIP/STUB1. Ubiquitination is regulated by the HSP90 chaperone and regulates the receptor stability
    • and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P29317

    • 4/20 DME Specific Peptides for EPHA2 (P29317) (see all 20)
     RDLAARN  NWLRTNW  CKETFNL  QLVGMLRG 

    EPHA2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004422.2  
    ENSEMBL proteins: 
     ENSP00000351209  

    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant EPHA2 Protein
    R&D Systems Recombinant & Natural Proteins for EPHA2
    Enzo Life Sciences proteins for EPHA2
    OriGene Purified Protein: EPHA2
    OriGene Protein Over-expression Lysate: EPHA2
    OriGene Custom Protein Services for EPHA2 
    GenScript Custom Purified and Recombinant Proteins Services for EPHA2
    Novus Biologicals EPHA2 Proteins
    Novus Biologicals EPHA2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EPHA2

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0005887integral to plasma membrane IDA10655584
    GO:0005925focal adhesion IDA10655584
    GO:0031256leading edge membrane IDA19573808
    GO:0031258lamellipodium membrane IEA--


    EPHA2 for ontologies           About GeneDecksing



    EPHA2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of EPHA2
    R&D Systems Antibodies for EPHA2
    Cell Signaling Technology (CST) Antibodies for EPHA2 
    OriGene Antibodies (see all 2): EPHA2
    OriGene Custom Antibody Services for EPHA2 
    GenScript Custom Superior Antibodies Services for EPHA2
    Novus Biologicals EPHA2 Antibodies
    Abcam antibodies for EPHA2 
    Uscn Antibodies for EPHA2
    ThermoFisher Antibodies for EPHA2

    Assay Products for EPHA2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for EPHA2         (see all)
    GenScript EPHA2-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for EPHA2

    Protein Domains /
    Families
    for EPHA2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EPHA2 for domains           About GeneDecksing

    5/16 InterPro domains/families (see all 16):
     IPR017441 Protein_kinase_ATP_BS
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR003961 Fibronectin_type3

    Graphical View of Domain Structure for InterPro Entry P29317

    ProtoNet protein and cluster: P29317

    4 Blocks protein families:
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHA2_HUMAN, P29317
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Function
    for EPHA2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EPHA2_HUMAN, P29317
    Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway
    downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin
    ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration,
    integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation
    through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also
    participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell
    migration. During development, may function in distinctive aspects of pattern formation and subsequently in
    development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and
    epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand
    ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency
    development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of
    osteoclastogenesis and osteoblastogenesis
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Induction: Up-regulated by UV irradiation via a TP53-independent, MAPK-dependent mechanism

         Genatlas biochemistry entry for EPHA2:
    EPH related tyrosine kinase receptor,binding ephrins A,expressed in projecting neurons and their target fields,involved
    in short-range contact-mediated axonal guidance,highly expressed in metastatic melanoma cells

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
    Products:            		miRTarBase miRNAs that target EPHA2:
    hsa-mir-26b (MIRT005508)

    OriGene 3'-UTR Clone: EPHA2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPHA2
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate EPHA2 (see all 35):
    hsa-miR-520e hsa-miR-302d hsa-miR-548k hsa-miR-200a hsa-miR-519a hsa-miR-141 hsa-miR-124 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmid: EPHA2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPHA2 (see all 7)
    OriGene shRNA RFP: EPHA2
    OriGene siRNA: EPHA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHA2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for EPHA2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPHA2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPHA2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: EPHA2 (NM_004431)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA2 

    Cell Line
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    Search LifeMap BioReagents cell lines for EPHA2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004714transmembrane receptor protein tyrosine kinase activity IDA10655584
    GO:0005003ephrin receptor activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    EPHA2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for EPHA2:
     Increased cell death in HCC-19  Increased mitotic index 

    Animal Models:
         Mouse knock-out Epha2tm1Jrui for EPHA2
         9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Epha2):
     cardiovascular system  embryogenesis  homeostasis/metabolism  limbs/digits/tail  nervous system 
     normal  skeleton  tumorigenesis  vision/eye 

    EPHA2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for EPHA2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex1.00
    		CDC42 Pathway0.34
    		Actin Nucleation and Branching0.66
    5G-protein signaling_RhoA regulation pathway
    		G-protein signaling_RhoA regulation pathway1.00
    		EphrinA-EphR Signaling0.26
    		G-protein signaling RhoA regulation pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for EPHA2
        Neurophysiological process Receptor-mediated axon growth repulsion
    Cell adhesion Ephrins signaling
    G-protein signaling RhoA regulation pathway

    5/32 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPHA2 (see all 32)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    P2Y Receptor Signaling

    2 Cell Signaling Technology (CST) Pathways for EPHA2
        Angiogenesis
    Tyrosine Kinases / Adaptors

    3 GeneGo (Thomson Reuters) Pathways for EPHA2
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    5/6 BioSystems Pathways for EPHA2 (see all 6) 
        EPHA2 forward signaling
    Direct p53 effectors
    Stabilization and expansion of the E-cadherin adherens junction
    EPHA forward signaling
    Arf6 signaling events


    1         Kegg Pathway  (Kegg details for EPHA2):
        Axon guidance


    EPHA2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EPHA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/67 Interacting proteins for EPHA2 (P293171, 2, 3 ENSP000003512094) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFNA1P208271, 2, 3, ENSP000003573924EBI-702104,EBI-715194 MINT-7218724 MINT-7218694 I2D: score=4 STRING: ENSP00000357392
    PTK2Q053971, 3, ENSP000003411894EBI-702104,EBI-702142 I2D: score=2 STRING: ENSP00000341189
    EFNA3P527973, ENSP000003573934I2D: score=3 STRING: ENSP00000357393
    PTPN11Q061243, ENSP000003409444I2D: score=3 STRING: ENSP00000340944
    SHC1P293533, ENSP000004013034I2D: score=3 STRING: ENSP00000401303
    About this table

    Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IEA--
    GO:0001525angiogenesis IEA--
    GO:0001568blood vessel development ----
    GO:0001570vasculogenesis IEA--
    GO:0001649osteoblast differentiation ISS--


    EPHA2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for EPHA2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EPHA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EPHA2

    2 HMDB Compounds for EPHA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 DrugBank Compounds for EPHA2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dasatinib-- 302962-49-8targetantagonist17139284 20072833 17016423
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--17139284 17016423

    6 Novoseek chemical compound relationships for EPHA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 76.6 81 18387945 (4), 11309274 (4), 16426859 (3), 10511313 (2) (see all 54)
    vegf 16.7 15 18485799 (8), 17767065 (4), 17680030 (2), 15579670 (1)
    phosphoinositide 14.2 3 17135240 (1), 20028874 (1)
    phosphotyrosine 12.6 2 10511313 (1)
    agar 0 4 12019162 (2), 15359289 (1)
    estrogen 0 8 12810680 (4), 11968011 (2), 19396818 (1)

    Search CenterWatch for drugs/clinical trials and news about EPHA2 

    Transcripts
    for EPHA2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EPHA2 gene: 
    NM_004431.3  

    Unigene Cluster for EPHA2:

    EPH receptor A2
    Hs.171596  [show with all ESTs]
    Unigene Representative Sequence: NM_004431
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358432(uc001aya.2 uc010oca.2) ENST00000462805 ENST00000480202
    ENST00000461614

    miRNA
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    hsa-miR-520e hsa-miR-302d hsa-miR-548k hsa-miR-200a hsa-miR-519a hsa-miR-141 hsa-miR-124 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmid: EPHA2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPHA2 (see all 7)
    OriGene shRNA RFP: EPHA2
    OriGene siRNA: EPHA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHA2
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: EPHA2 (NM_004431)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EPHA2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPHA2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHA2

    Additional cDNA sequence: 

    AK296788.1 BC008655.1 BC037166.2 EU826606.1 M59371.1 

    7 DOTS entries:

    DT.447452  DT.99979334  DT.100044652  DT.100776917  DT.91853271  DT.95223102  DT.95312785 

    24/215 AceView cDNA sequences (see all 215):

    AW271604 AW271226 BU685241 BQ684233 BU173612 BM783663 AI392840 BQ680319 
    BF000238 BM743787 CB991812 BF062514 BF588542 NM_004431 BQ100980 BQ883580 
    AI056826 BQ691197 CB991802 AA513018 BU527500 CD110234 AL138105 BU684699 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for EPHA2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18
    SP1:                                                                                                                                                
    SP2:                                                                                                                                                
    SP3:                                                                                                                                                
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for EPHA2

    Expression
    for EPHA2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EPHA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCCAGTCGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    EPHA2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeMesencephalic Floor PlateEarly Floor Plate CellsNeural Ectoderm
    Neural TubeMesencephalic Floor PlateLate Floor Plate CellsNeural Ectoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    HSF-1 (UC01) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Definitive endoderm-like cells (A scalable, suspensi...)

    See EPHA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EPHA2

    SOURCE GeneReport for Unigene cluster: Hs.171596

    UniProtKB/Swiss-Prot: EPHA2_HUMAN, P29317
    Tissue specificity: Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most
    highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung, and ovary

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    Orthologs
    for EPHA2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for EPHA2 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves EPHA21 EPH receptor A2 75.74(n)
    75.42(a)    		   771550  XM_001234813.2  XP_001234814.2 
    lizard
    (Anolis carolinensis)    		 Reptilia EPHA26
    EPHA76
    		 --
    		 72(a)
    38(a)
    		 1 ↔ 1
    possible ortholog
    		 GL344107.1(15974-45452)
    1(178449919-178646965)
    African clawed frog
    (Xenopus laevis)    		 Amphibia epha2-A2 ephrin receptor EphA2 (tyrosine kinase family) 77.39(n)    BC060745.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii epha21 eph receptor A2 60.89(n)
    57.32(a)    		   30689  NM_131415.1  NP_571490.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta hop3 JAK-STAT cascade protein tyrosine kinase 41(a)
    (best of 2)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea kin-243 tyrosine-protein kinase 32(a)   IV(9839286-9841152)   --


    ENSEMBL Gene Tree for EPHA2 (if available)
    TreeFam Gene Tree for EPHA2 (if available) 

    Paralogs
    for EPHA2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EPHA2 gene
    EPHB12  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHB22  EPHA12  
    EPHA82  EPHA32  EPHA72  EPHB42  EPHA102  
    18/110 SIMAP similar genes for EPHA2 using alignment to 4 protein entries:     EPHA2_HUMAN (see all proteins) (see all similar genes):
    EPHA6    EPHB2 variant protein    EPHA4    EPHA7    EPHA3    EPHB3
    EPHB1    BTK kinase deficient isoform 2    HCK    EPHA5    FYN    FES
    FER    MET    TXK    EPHB2    LYN    NTRK2

    EPHA2 for paralogs           About GeneDecksing



    Genomic Variants
    for EPHA2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/619 NCBI SNPs in EPHA2 are shown (see all 619)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1165066141,2
    		C,F,pathogenic15772129(+) TGCCCC/TGCAGC 2 Q R mis12Minor allele frequency- T:0.00NA EU 5875
    rs1440755621,2
    		Cother15768610(+) GGCCCA/C/TCCAGC 3 E G V mis11NA 4340
    rs1115121841,2
    		--14968885(+) TAGAAA/TCTTAT 1 -- ut312Minor allele frequency- T:0.10CSA WA 120
    rs785698981,2
    		--14968913(+) GGGGCC/TGACTG 1 -- ut312Minor allele frequency- T:0.08CSA WA 120
    rs1138105311,2
    		C,--14969184(+) GTCTCA/GCCCAG 1 -- ut312Minor allele frequency- G:0.10CSA WA 120
    rs1126000021,2
    		C--14969414(+) TGTGTG/ACGTCT 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs115439351,2
    		C,--14969461(+) ATCTCC/TTCAGT 1 -- ut31 ese32Minor allele frequency- T:0.06CSA WA 120
    rs728879161,2
    		C,--14969974(+) AAAACG/AACAGA 1 -- int12Minor allele frequency- A:0.05WA 120
    rs588121991,2
    		F,--14970459(+) CCTCCC/TGTGTA 1 -- int11Minor allele frequency- T:0.08WA 118
    rs610499731,2
    		--14970527(+) GGAAGG/TCAGCA 1 -- int12Minor allele frequency- T:0.09CSA WA 120

    HapMap Linkage Disequilibrium report for EPHA2 (16450832 - 16482582 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for EPHA2: --
    Human Gene Mutation Database (HGMD): EPHA2

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for EPHA2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EPHA2 for disorders           About GeneDecksing

    OMIM gene information: 176946   
    OMIM disorders: 613020  
    UniProtKB/Swiss-Prot: EPHA2_HUMAN, P29317
  • Genetic variations in EPHA2 are the cause of susceptibility to cataract cortical age-related type 2 (ARCC2)
    • [MIM:613020]. A developmental punctate opacity common in the cortex and present in most lenses. The cataract is white
    or cerulean, increases in number with age, but rarely affects vision
  • Defects in EPHA2 are the cause of cataract posterior polar type 1 (CTPP1) [MIM:116600]. A subcapsular opacity,
    • usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity
  • Note=Overexpressed in several cancer types and promotes malignancy

    • 20/53 diseases for EPHA2 (see all 53):    About MalaCards
    cataract, posterior polar, 1    cataract    brain stem glioma    squamous cell carcinoma
    squamous cell carcinoma of the head and neck    esophageal squamous cell carcinoma    pancreatic ductal adenocarcinoma    lung squamous cell carcinoma
    hearing loss    congenital fibrosarcoma    malignant mesothelioma    congenital cataracts
    carcinoma    brain glioma    malignant glioma    renal cell carcinoma
    colon carcinoma    ovarian carcinoma    rheumatoid arthritis    colon cancer

    1 disease from the University of Copenhagen DISEASES database for EPHA2:
    Cancer

    10/34 Novoseek disease relationships for EPHA2 gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mimicry 60.2 6 12941789 (1), 11309274 (1), 16481735 (1), 19223760 (1) (see all 6)
    tumors 54.1 208 11146556 (6), 16533422 (6), 16849550 (6), 19484140 (5) (see all 62)
    cancer 49.9 78 19948216 (5), 17374733 (3), 19690146 (3), 14767510 (3) (see all 35)
    metastatic melanoma 48 4 14679012 (1), 11309274 (1)
    ovarian cancer 45.3 19 16300469 (3), 18443431 (3), 17154180 (3), 16969087 (2) (see all 10)
    metastasis 42.8 48 19264906 (4), 14767510 (3), 19788698 (3), 19934338 (3) (see all 19)
    melanoma 42.4 24 19223760 (6), 7780963 (5), 16481735 (2), 12941789 (1) (see all 8)
    glioma 42.4 16 18614215 (4), 16207473 (3), 17332925 (3), 18324354 (1) (see all 7)
    ovarian carcinoma 39.9 12 15297418 (4), 16061279 (3), 19395869 (2), 16969087 (1) (see all 5)
    glioblastoma multiforme 34.2 5 16254188 (2), 16207473 (1), 18097589 (1), 18172271 (1)

    Human Genome Epidemiology (HuGE) Navigator: EPHA2 (2 documents)

    Export disorders for EPHA2 gene to outside databases

    Publications
    for EPHA2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EPHA2 gene, integrated from 9 sources (see all 262):
    (articles sorted by number of sources associating them with EPHA2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. EphA2 is an essential mediator of UV radiation-induced apoptosis. (PubMed id 18339848)1, 2, 9 Zhang G.... Tsao H. (2008)
    2. EphA2 mediates ligand-dependent inhibition and ligand -independent promotion of cell migration and invasion via a reciprocal regulato ry loop with Akt. (PubMed id 19573808)1, 2, 9 Miao H....Wang B. (2009)
    3. EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability. (PubMed id 16236711)1, 2, 9 Tanaka M....Sakai R. (2005)
    4. Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK. (PubMed id 17332925)1, 2, 9 Liu D.P....Xie D. (2007)
    5. Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography. (PubMed id 12467573)1, 2, 9 Nowakowski J....Thompson D.A. (2002)
    6. cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. (PubMed id 2174105)1, 2, 9 Lindberg R.A. and Hunter T. (1990)
    7. Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation. (PubMed id 12167657)1, 2, 9 Kikawa K.D....Kinch M.S. (2002)
    8. Human cataract mutations in EPHA2 SAM domain alter receptor stability and function. (PubMed id 22570727)1, 2 Park J.E.... Zhou R. (2012)
    9. Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1. (PubMed id 20861311)1, 2 Lin S.... Getsios S. (2010)
    10. Ephexin4 and EphA2 mediate cell migration through a R hoG-dependent mechanism. (PubMed id 20679435)1, 2 Hiramoto-Yamaki N....Katoh H. (2010)

    External Searches for EPHA2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing EPHA2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1969 HGNC: 3386 AceView: EPHA2 Ensembl:ENSG00000142627 euGenes: HUgn1969
    ECgene: EPHA2 Kegg: 1969 H-InvDB: EPHA2

    Other Databases showing EPHA2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing EPHA2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EPHA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHA2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for EPHA2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for EPHA2 gene:
    Search GeneIP for patents involving EPHA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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