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Aliases for EPHA10 Gene

Aliases for EPHA10 Gene

  • EPH Receptor A10 2 3 5
  • EC 2.7.10.1 4 61

External Ids for EPHA10 Gene

Previous GeneCards Identifiers for EPHA10 Gene

  • GC01M037895
  • GC01M037952
  • GC01M038181
  • GC01M036298

Summaries for EPHA10 Gene

Entrez Gene Summary for EPHA10 Gene

  • Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]

GeneCards Summary for EPHA10 Gene

EPHA10 (EPH Receptor A10) is a Protein Coding gene. Among its related pathways are EPH-Ephrin signaling and Developmental Biology. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHA7.

UniProtKB/Swiss-Prot for EPHA10 Gene

  • Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.

Tocris Summary for EPHA10 Gene

  • Eph receptors are the largest family of receptor tyrosine kinases (RTKs) and are divided into two subclasses, EphA and EphB. Originally identified as mediators of axon guidance, Eph receptors are implicated in many processes, particularly cancer development and progression.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHA10 Gene

Genomics for EPHA10 Gene

Regulatory Elements for EPHA10 Gene

Enhancers for EPHA10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F037696 0.2 ENCODE 50 +67.7 67660 1.5 ZBTB40 EPHA10 INPP5B C1orf109 CDCA8 GC01P037710 PIR57553
GH01F037688 0.4 ENCODE 37.9 +74.0 74030 4.9 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 EPHA10 GNL2 SF3A3 C1orf109 SNIP1 DNALI1 GC01P037645
GH01F037682 0.2 ENCODE 36.4 +82.5 82477 0.8 CTCF ZNF654 JUN TRIM22 REST RAD21 POLR2H JUND TCF7 ZNF143 EPHA10 GNL2 ENSG00000233728 C1orf109 GC01P037645
GH01F037318 0.3 FANTOM5 19.5 +446.4 446389 0.3 ZFHX2 EGR2 EPHA10 GRIK3 GC01P037318 ENSG00000223944
GH01F037737 0.3 FANTOM5 11.3 +27.2 27203 0.0 EPHA10 ENSG00000233728 ENSG00000200421 GC01M037738 PIR41573
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around EPHA10 on UCSC Golden Path with GeneCards custom track

Genomic Location for EPHA10 Gene

Chromosome:
1
Start:
37,713,880 bp from pter
End:
37,765,152 bp from pter
Size:
51,273 bases
Orientation:
Minus strand

Genomic View for EPHA10 Gene

Genes around EPHA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPHA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPHA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHA10 Gene

Proteins for EPHA10 Gene

  • Protein details for EPHA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JZY3-EPHAA_HUMAN
    Recommended name:
    Ephrin type-A receptor 10
    Protein Accession:
    Q5JZY3
    Secondary Accessions:
    • A4FU89
    • J3KPB5
    • Q6NW42

    Protein attributes for EPHA10 Gene

    Size:
    1008 amino acids
    Molecular mass:
    109716 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI12934.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for EPHA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHA10 Gene

Selected DME Specific Peptides for EPHA10 Gene

Q5JZY3:
  • MKLNTEVR
  • EELYFHFK
  • DTIAADE
  • ALVSVRV
  • FAKELDA
  • TYQVCNV
  • CTRPPSAP
  • GERPYWD
  • LAFQDVGAC
  • YVFQIRA
  • GWEEISG
  • LMLDCWQK

Post-translational modifications for EPHA10 Gene

  • Glycosylation at Asn 311 and Asn 486
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for EPHA10
  • Cloud-Clone Corp. Antibodies for EPHA10

Domains & Families for EPHA10 Gene

Suggested Antigen Peptide Sequences for EPHA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JZY3

UniProtKB/Swiss-Prot:

EPHAA_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Contains 2 fibronectin type-III domains.
  • Contains 1 protein kinase domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
genes like me logo Genes that share domains with EPHA10: view

Function for EPHA10 Gene

Molecular function for EPHA10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.

Enzyme Numbers (IUBMB) for EPHA10 Gene

Gene Ontology (GO) - Molecular Function for EPHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA --
GO:0005003 ephrin receptor activity IEA --
GO:0005515 protein binding IPI 15777695
genes like me logo Genes that share ontologies with EPHA10: view
genes like me logo Genes that share phenotypes with EPHA10: view

Animal Models for EPHA10 Gene

MGI Knock Outs for EPHA10:

Animal Model Products

  • Taconic Biosciences Mouse Models for EPHA10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for EPHA10 Gene

Localization for EPHA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHA10 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPHA10 Gene COMPARTMENTS Subcellular localization image for EPHA10 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EPHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EPHA10: view

Pathways & Interactions for EPHA10 Gene

genes like me logo Genes that share pathways with EPHA10: view

Gene Ontology (GO) - Biological Process for EPHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0008150 biological_process ND --
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with EPHA10: view

No data available for SIGNOR curated interactions for EPHA10 Gene

Drugs & Compounds for EPHA10 Gene

(1) Drugs for EPHA10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for EPHA10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with EPHA10: view

Transcripts for EPHA10 Gene

mRNA/cDNA for EPHA10 Gene

(5) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EPHA10 Gene

EPH receptor A10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPHA10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - -
SP2: - -
SP3:

Relevant External Links for EPHA10 Gene

GeneLoc Exon Structure for
EPHA10
ECgene alternative splicing isoforms for
EPHA10

Expression for EPHA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EPHA10 Gene

mRNA differential expression in normal tissues according to GTEx for EPHA10 Gene

This gene is overexpressed in Colon - Transverse (x9.7) and Testis (x7.0).

Protein differential expression in normal tissues from HIPED for EPHA10 Gene

This gene is overexpressed in Spleen (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EPHA10 Gene



Protein tissue co-expression partners for EPHA10 Gene

NURSA nuclear receptor signaling pathways regulating expression of EPHA10 Gene:

EPHA10

SOURCE GeneReport for Unigene cluster for EPHA10 Gene:

Hs.129435

mRNA Expression by UniProt/SwissProt for EPHA10 Gene:

Q5JZY3-EPHAA_HUMAN
Tissue specificity: Mainly expressed in testis.
genes like me logo Genes that share expression patterns with EPHA10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for EPHA10 Gene

Orthologs for EPHA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EPHA10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EPHA10 34 35
  • 91.07 (n)
mouse
(Mus musculus)
Mammalia Epha10 34 16
  • 87.85 (n)
rat
(Rattus norvegicus)
Mammalia Epha10 34
  • 84.81 (n)
chicken
(Gallus gallus)
Aves EPHA10 34 35
  • 68.84 (n)
zebrafish
(Danio rerio)
Actinopterygii epha4b 35
  • 45 (a)
ManyToMany
Species where no ortholog for EPHA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EPHA10 Gene

ENSEMBL:
Gene Tree for EPHA10 (if available)
TreeFam:
Gene Tree for EPHA10 (if available)

Paralogs for EPHA10 Gene

Paralogs for EPHA10 Gene

genes like me logo Genes that share paralogs with EPHA10: view

Variants for EPHA10 Gene

Sequence variations from dbSNP and Humsavar for EPHA10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs771803475 A gastric adenocarcinoma sample 37,761,806(+) TTTTG(C/T)GGGGC reference, missense
VAR_042163 A breast infiltrating ductal carcinoma sample
rs1008879 -- 37,720,622(+) CAGGG(C/T)GGTCA intron-variant
rs1010805 -- 37,723,470(-) GGCCT(G/T)GTCTT intron-variant
rs10157024 -- 37,765,397(+) TGGCC(C/T)AGAGC downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EPHA10 Gene

Variant ID Type Subtype PubMed ID
esv1005346 CNV deletion 20482838
esv2276987 CNV deletion 18987734
esv2660836 CNV deletion 23128226
esv2671162 CNV deletion 23128226
esv2747230 CNV deletion 23290073
esv2747241 CNV deletion 23290073
esv2747253 CNV deletion 23290073
esv2747264 CNV deletion 23290073
esv3560926 CNV deletion 23714750
esv3585759 CNV loss 21293372
nsv1078328 CNV deletion 25765185
nsv1122330 CNV deletion 24896259
nsv1122331 CNV deletion 24896259
nsv1136076 CNV deletion 24896259
nsv519553 CNV loss 19592680
nsv525226 CNV loss 19592680
nsv956619 CNV deletion 24416366

Variation tolerance for EPHA10 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.93; 95.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPHA10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EPHA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHA10 Gene

Disorders for EPHA10 Gene

Relevant External Links for EPHA10

Genetic Association Database (GAD)
EPHA10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EPHA10

No disorders were found for EPHA10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EPHA10 Gene

Publications for EPHA10 Gene

  1. Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis. (PMID: 15777695) Aasheim H.-C. … Finne E.F. (Biochim. Biophys. Acta 2005) 3 4 22 64
  2. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3 46 64
  3. Expression profile of Eph receptors and ephrin ligands in healthy human B lymphocytes and chronic lymphocytic leukemia B-cells. (PMID: 18819711) Alonso-C L.M. … Zapata A.G. (Leuk. Res. 2009) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for EPHA10 Gene

Sources for EPHA10 Gene

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