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Aliases for EPHA10 Gene

Aliases for EPHA10 Gene

  • EPH Receptor A10 2 3
  • EC 2.7.10.1 4 63

External Ids for EPHA10 Gene

Summaries for EPHA10 Gene

Entrez Gene Summary for EPHA10 Gene

  • Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]

GeneCards Summary for EPHA10 Gene

EPHA10 (EPH Receptor A10) is a Protein Coding gene. GO annotations related to this gene include transmembrane-ephrin receptor activity and ephrin receptor activity. An important paralog of this gene is EPHB3.

UniProtKB/Swiss-Prot for EPHA10 Gene

  • Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHA10 Gene

Genomics for EPHA10 Gene

Genomic Location for EPHA10 Gene

Start:
37,713,880 bp from pter
End:
37,765,152 bp from pter
Size:
51,273 bases
Orientation:
Minus strand

Genomic View for EPHA10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPHA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHA10 Gene

Regulatory Elements for EPHA10 Gene

Proteins for EPHA10 Gene

  • Protein details for EPHA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JZY3-EPHAA_HUMAN
    Recommended name:
    Ephrin type-A receptor 10
    Protein Accession:
    Q5JZY3
    Secondary Accessions:
    • A4FU89
    • J3KPB5
    • Q6NW42

    Protein attributes for EPHA10 Gene

    Size:
    1008 amino acids
    Molecular mass:
    109716 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI12934.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for EPHA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHA10 Gene

Proteomics data for EPHA10 Gene at MOPED

Post-translational modifications for EPHA10 Gene

  • Glycosylation at Asn311 and Asn486

Domains for EPHA10 Gene

Gene Families for EPHA10 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing
  • FN3 :Fibronectin type III domain containing
  • EPH :EPH receptors
IUPHAR :

Suggested Antigen Peptide Sequences for EPHA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JZY3

UniProtKB/Swiss-Prot:

EPHAA_HUMAN
Domain:
  • The protein kinase domain is predicted to be catalytically inactive:
    • Q5JZY3
  • Contains 1 Eph LBD (Eph ligand-binding) domain.:
    • Q5JZY3
  • Contains 2 fibronectin type-III domains.:
    • Q5JZY3
  • Contains 1 protein kinase domain.:
    • Q5JZY3
  • Contains 1 SAM (sterile alpha motif) domain.:
    • Q5JZY3
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.:
    • Q5JZY3
genes like me logo Genes that share domains with EPHA10: view

Function for EPHA10 Gene

Molecular function for EPHA10 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
UniProtKB/Swiss-Prot Function: Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.

Enzyme Numbers (IUBMB) for EPHA10 Gene

Gene Ontology (GO) - Molecular Function for EPHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0005003 ephrin receptor activity IEA --
GO:0005005 transmembrane-ephrin receptor activity IDA 15777695
GO:0005515 protein binding IPI 15777695
genes like me logo Genes that share ontologies with EPHA10: view

Phenotypes for EPHA10 Gene

GenomeRNAi human phenotypes for EPHA10:
genes like me logo Genes that share phenotypes with EPHA10: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for EPHA10 Gene

Localization for EPHA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHA10 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPHA10 Gene COMPARTMENTS Subcellular localization image for EPHA10 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EPHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016021 integral component of membrane NAS 15777695
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with EPHA10: view

Pathways for EPHA10 Gene

SuperPathways for EPHA10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EPHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway --
GO:0007411 axon guidance TAS --
GO:0008150 biological_process ND --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with EPHA10: view

No data available for Pathways by source for EPHA10 Gene

Compounds for EPHA10 Gene

(2) HMDB Compounds for EPHA10 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with EPHA10: view

Transcripts for EPHA10 Gene

mRNA/cDNA for EPHA10 Gene

(4) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EPHA10 Gene

EPH receptor A10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPHA10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - -
SP2: - -
SP3:

Relevant External Links for EPHA10 Gene

GeneLoc Exon Structure for
EPHA10
ECgene alternative splicing isoforms for
EPHA10

Expression for EPHA10 Gene

mRNA expression in normal human tissues for EPHA10 Gene

mRNA differential expression in normal tissues according to GTEx for EPHA10 Gene

This gene is overexpressed in Colon - Transverse (9.7) and Testis (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EPHA10 Gene

SOURCE GeneReport for Unigene cluster for EPHA10 Gene Hs.129435

mRNA Expression by UniProt/SwissProt for EPHA10 Gene

Q5JZY3-EPHAA_HUMAN
Tissue specificity: Mainly expressed in testis.
genes like me logo Genes that share expressions with EPHA10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for EPHA10 Gene

Orthologs for EPHA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EPHA10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EPHA10 35
  • 91.07 (n)
  • 93.85 (a)
EPHA10 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Epha10 35
  • 87.85 (n)
  • 92.75 (a)
Epha10 16
rat
(Rattus norvegicus)
Mammalia Epha10 35
  • 84.81 (n)
  • 88.58 (a)
chicken
(Gallus gallus)
Aves EPHA10 35
  • 68.84 (n)
  • 63.29 (a)
EPHA10 36
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii epha4b 36
  • 45 (a)
ManyToMany
Species with no ortholog for EPHA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EPHA10 Gene

ENSEMBL:
Gene Tree for EPHA10 (if available)
TreeFam:
Gene Tree for EPHA10 (if available)

Paralogs for EPHA10 Gene

Paralogs for EPHA10 Gene

genes like me logo Genes that share paralogs with EPHA10: view

Variants for EPHA10 Gene

Sequence variations from dbSNP and Humsavar for EPHA10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs477505 -- 37,756,007(+) CTGTC(C/T)GGAAG intron-variant
rs478492 -- 37,741,643(+) AGATC(A/C)AAAAG intron-variant
rs482176 -- 37,756,521(+) CCCTC(C/T)CTTCA intron-variant
rs483201 -- 37,742,153(+) GCACC(G/T)GCTCT intron-variant
rs484927 -- 37,742,328(+) tctgg(C/T)tgttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPHA10 Gene

Variant ID Type Subtype PubMed ID
esv2660836 CNV Deletion 23128226
nsv519553 CNV Loss 19592680
nsv525226 CNV Loss 19592680
nsv871810 CNV Loss 21882294
esv2276987 CNV Deletion 18987734
esv2747230 CNV Deletion 23290073
esv2747241 CNV Deletion 23290073
esv2671162 CNV Deletion 23128226
esv1005346 CNV Deletion 20482838
esv2747253 CNV Deletion 23290073
esv2747264 CNV Deletion 23290073

Relevant External Links for EPHA10 Gene

HapMap Linkage Disequilibrium report
EPHA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHA10 Gene

Disorders for EPHA10 Gene

(1) University of Copenhagen DISEASES for EPHA10 Gene

Relevant External Links for EPHA10

Genetic Association Database (GAD)
EPHA10
genes like me logo Genes that share disorders with EPHA10: view

No data available for UniProtKB/Swiss-Prot for EPHA10 Gene

Publications for EPHA10 Gene

  1. Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis. (PMID: 15777695) Aasheim H.-C. … Finne E.F. (Biochim. Biophys. Acta 2005) 3 4 23
  2. Expression profile of Eph receptors and ephrin ligands in healthy human B lymphocytes and chronic lymphocytic leukemia B-cells. (PMID: 18819711) Alonso-C L.M. … Zapata A.G. (Leuk. Res. 2009) 3 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3 48

Products for EPHA10 Gene

Sources for EPHA10 Gene

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