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Aliases for EPHA10 Gene

Aliases for EPHA10 Gene

  • EPH Receptor A10 2 3 5
  • EC 2.7.10.1 4 63

External Ids for EPHA10 Gene

Previous GeneCards Identifiers for EPHA10 Gene

  • GC01M037895
  • GC01M037952
  • GC01M038181
  • GC01M036298

Summaries for EPHA10 Gene

Entrez Gene Summary for EPHA10 Gene

  • Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]

GeneCards Summary for EPHA10 Gene

EPHA10 (EPH Receptor A10) is a Protein Coding gene. Among its related pathways are Developmental Biology and EPH-Ephrin signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

UniProtKB/Swiss-Prot for EPHA10 Gene

  • Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.

Tocris Summary for EPHA10 Gene

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHA10 Gene

Genomics for EPHA10 Gene

Regulatory Elements for EPHA10 Gene

Genomic Location for EPHA10 Gene

Chromosome:
1
Start:
37,713,880 bp from pter
End:
37,765,152 bp from pter
Size:
51,273 bases
Orientation:
Minus strand

Genomic View for EPHA10 Gene

Genes around EPHA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPHA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPHA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHA10 Gene

Proteins for EPHA10 Gene

  • Protein details for EPHA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JZY3-EPHAA_HUMAN
    Recommended name:
    Ephrin type-A receptor 10
    Protein Accession:
    Q5JZY3
    Secondary Accessions:
    • A4FU89
    • J3KPB5
    • Q6NW42

    Protein attributes for EPHA10 Gene

    Size:
    1008 amino acids
    Molecular mass:
    109716 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI12934.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for EPHA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHA10 Gene

Proteomics data for EPHA10 Gene at MOPED

Post-translational modifications for EPHA10 Gene

  • Glycosylation at Asn 311 and Asn 486
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for EPHA10 Gene

Suggested Antigen Peptide Sequences for EPHA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JZY3

UniProtKB/Swiss-Prot:

EPHAA_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Contains 2 fibronectin type-III domains.
  • Contains 1 protein kinase domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
genes like me logo Genes that share domains with EPHA10: view

Function for EPHA10 Gene

Molecular function for EPHA10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.

Enzyme Numbers (IUBMB) for EPHA10 Gene

genes like me logo Genes that share phenotypes with EPHA10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EPHA10

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EPHA10 Gene

Localization for EPHA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHA10 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPHA10 Gene COMPARTMENTS Subcellular localization image for EPHA10 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EPHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,NAS 15777695
genes like me logo Genes that share ontologies with EPHA10: view

Pathways & Interactions for EPHA10 Gene

genes like me logo Genes that share pathways with EPHA10: view

Gene Ontology (GO) - Biological Process for EPHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance TAS --
GO:0048013 ephrin receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with EPHA10: view

No data available for SIGNOR curated interactions for EPHA10 Gene

Drugs & Compounds for EPHA10 Gene

(1) Drugs for EPHA10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for EPHA10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with EPHA10: view

Transcripts for EPHA10 Gene

mRNA/cDNA for EPHA10 Gene

(4) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EPHA10 Gene

EPH receptor A10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPHA10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - -
SP2: - -
SP3:

Relevant External Links for EPHA10 Gene

GeneLoc Exon Structure for
EPHA10
ECgene alternative splicing isoforms for
EPHA10

Expression for EPHA10 Gene

mRNA expression in normal human tissues for EPHA10 Gene

mRNA differential expression in normal tissues according to GTEx for EPHA10 Gene

This gene is overexpressed in Colon - Transverse (x9.7) and Testis (x7.0).

Protein differential expression in normal tissues from HIPED for EPHA10 Gene

This gene is overexpressed in Spleen (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EPHA10 Gene



SOURCE GeneReport for Unigene cluster for EPHA10 Gene Hs.129435

mRNA Expression by UniProt/SwissProt for EPHA10 Gene

Q5JZY3-EPHAA_HUMAN
Tissue specificity: Mainly expressed in testis.
genes like me logo Genes that share expression patterns with EPHA10: view

Protein tissue co-expression partners for EPHA10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for EPHA10 Gene

Orthologs for EPHA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EPHA10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EPHA10 35
  • 91.07 (n)
  • 93.85 (a)
EPHA10 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Epha10 35
  • 87.85 (n)
  • 92.75 (a)
Epha10 16
rat
(Rattus norvegicus)
Mammalia Epha10 35
  • 84.81 (n)
  • 88.58 (a)
chicken
(Gallus gallus)
Aves EPHA10 35
  • 68.84 (n)
  • 63.29 (a)
EPHA10 36
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii epha4b 36
  • 45 (a)
ManyToMany
Species with no ortholog for EPHA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EPHA10 Gene

ENSEMBL:
Gene Tree for EPHA10 (if available)
TreeFam:
Gene Tree for EPHA10 (if available)

Paralogs for EPHA10 Gene

genes like me logo Genes that share paralogs with EPHA10: view

No data available for Paralogs for EPHA10 Gene

Variants for EPHA10 Gene

Sequence variations from dbSNP and Humsavar for EPHA10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_042159 A gastric adenocarcinoma sample
rs56276182 - 37,761,596(+) GGAAC(G/T)TGGCC reference, missense
rs4653328 - 37,761,414(+) GCAGA(A/T)GTCAC reference, missense
VAR_042162 -
VAR_042163 A breast infiltrating ductal carcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for EPHA10 Gene

Variant ID Type Subtype PubMed ID
esv2660836 CNV Deletion 23128226
nsv519553 CNV Loss 19592680
nsv525226 CNV Loss 19592680
nsv871810 CNV Loss 21882294
esv2276987 CNV Deletion 18987734
esv2747230 CNV Deletion 23290073
esv2747241 CNV Deletion 23290073
esv2671162 CNV Deletion 23128226
esv1005346 CNV Deletion 20482838
esv2747253 CNV Deletion 23290073
esv2747264 CNV Deletion 23290073

Variation tolerance for EPHA10 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.93; 95.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPHA10 Gene

HapMap Linkage Disequilibrium report
EPHA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHA10 Gene

Disorders for EPHA10 Gene

Relevant External Links for EPHA10

Genetic Association Database (GAD)
EPHA10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EPHA10

No disorders were found for EPHA10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EPHA10 Gene

Publications for EPHA10 Gene

  1. Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis. (PMID: 15777695) Aasheim H.-C. … Finne E.F. (Biochim. Biophys. Acta 2005) 3 4 23 67
  2. Expression profile of Eph receptors and ephrin ligands in healthy human B lymphocytes and chronic lymphocytic leukemia B-cells. (PMID: 18819711) Alonso-C L.M. … Zapata A.G. (Leuk. Res. 2009) 3 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Eph receptor A10 has a potential as a target for a prostate cancer therapy. (PMID: 24924629) Nagano K. … Tsunoda S. (Biochem. Biophys. Res. Commun. 2014) 3
  5. Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers. (PMID: 24946238) Nagano K. … Tsunoda S. (J Control Release 2014) 3

Products for EPHA10 Gene

Sources for EPHA10 Gene

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