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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EPHA1 Gene

protein-coding   GIFtS: 67
GCID: GC07M143087

EPH Receptor A1

(Previous name: EphA1)
(Previous symbols: EPHT, EPHT1)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
EPH Receptor A11 2     EphA11
EPHT11 2 3 5     Ephrin Type-A Receptor 12
EPHT1 2 3     Erythropoietin-Producing Hepatoma Amplified Sequence2
EPH Tyrosine Kinase 12 3     Oncogene EPH2
Erythropoietin-Producing Hepatoma Receptor2 3     Soluble EPHA1 Variant 12
Tyrosine-Protein Kinase Receptor EPH2 3     Soluble EPHA1 Variant 22
EPH2 3     EPH Tyrosine Kinase3
hEpha12 3     EC 2.7.108
EC 2.7.10.13 8     

External Ids:    HGNC: 33851   Entrez Gene: 20412   Ensembl: ENSG000001469047   OMIM: 1796105   UniProtKB: P217093   

Export aliases for EPHA1 gene to outside databases

Previous GC identifers: GC07M141414 GC07M142482 GC07M142559 GC07M142605 GC07M142798 GC07M137425


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EPHA1 Gene:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related
receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors
in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich
domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity
of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene
is expressed in some human cancer cell lines and has been implicated in carcinogenesis. (provided by RefSeq, Jul
2008)

GeneCards Summary for EPHA1 Gene: 
EPHA1 (EPH receptor A1) is a protein-coding gene. Diseases associated with EPHA1 include craniofrontonasal syndrome, and placental insufficiency, and among its related super-pathways are Ras Pathway and MAPK Signaling. GO annotations related to this gene include transmembrane-ephrin receptor activity and protein kinase binding. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHA1_HUMAN, P21709
Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high
affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces
cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and
downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in
apoptosis

Gene Wiki entry for EPHA1 (EPH receptor A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EPHA1 gene promoter:
         Max1   AP-1   ATF-2   STAT3   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPHA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for EPHA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q35   HGNC cytogenetic band: 7q32-q36

EPHA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHA1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M143087:  view genomic region     (about GC identifiers)

Start:
143,087,382 bp from pter      End:
143,105,985 bp from pter
Size:
18,604 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 142,490,337-142,508,118     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EPHA1_HUMAN, P21709 (See protein sequence)
Recommended Name: Ephrin type-A receptor 1 precursor  
Size: 976 amino acids; 108127 Da
Subunit: Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1;
regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but
independent of the kinase activity of EPHA1. Interacts (kinase activity-dependent) with PTK2/FAK1
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAA36747.1; Type=Frameshift; Positions=582, 595, 601;
4 PDB 3D structures from and Proteopedia for EPHA1:
2K1K (3D)        2K1L (3D)        3HIL (3D)        3KKA (3D)    
Secondary accessions: A1L3V3 Q15405

Explore the universe of human proteins at neXtProt for EPHA1: NX_P21709

Explore proteomics data for EPHA1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P21709

  • 4/8 DME Specific Peptides for EPHA1 (P21709) (see all 8)
     LAQFPDT  CKETFNL  TEFMENG  RDLAARN 

    EPHA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EPHA1 Protein Expression
    REFSEQ proteins: NP_005223.4  
    ENSEMBL proteins: 
     ENSP00000275815  

    Human Recombinant Protein Products for EPHA1: 
    EMD Millipore Purified and/or Recombinant EPHA1 Protein
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    Novus Biologicals EPHA1 Protein
    Sino Biological Recombinant Protein for EPHA1
    Sino Biological Cell Lysate for EPHA1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EPHA1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IDA19118217

    EPHA1 for ontologies           About GeneDecksing



    EPHA1 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for EPHA1 
    Cloud-Clone Corp. CLIAs for EPHA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor A1 
    Ephrin receptor family
    Ephrin receptor family

    5/16 InterPro protein domains (see all 16):
     IPR017441 Protein_kinase_ATP_BS
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR003961 Fibronectin_type3

    Graphical View of Domain Structure for InterPro Entry P21709

    ProtoNet protein and cluster: P21709

    2 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHA1_HUMAN, P21709
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    EPHA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHA1_HUMAN, P21709
    Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high
    affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces
    cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and
    downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in
    apoptosis
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for EPHA1:
    EPH-related tyrosine kinase receptor 1,binding ephrin A1,expressed in projecting neurons and their target
    fields,involved in short-range contact-mediated axonal guidance

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA12775584
    GO:0004713protein tyrosine kinase activity ----
    GO:0005003ephrin receptor activity ----
    GO:0005005transmembrane-ephrin receptor activity IDA19118217
    GO:0005515protein binding ----
         
    EPHA1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for EPHA1:
     Decreased TP53 protein express  Decreased substrate adherent c  Increased colony dispersion (i  Synthetic lethal with gemcitab 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Epha1):
     growth/size  homeostasis/metabolism  immune system  limbs/digits/tail  reproductive system 
     skeleton 

    EPHA1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for EPHA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EPHA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPHA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPHA1 

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate EPHA1 (see all 13):
    hsa-miR-520d-5p hsa-miR-15a hsa-miR-3065-3p hsa-miR-497 hsa-miR-4287 hsa-miR-211 hsa-miR-656 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidEPHA1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for EPHA1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA1
    Sirion Biotech Customized lentivirus for stable overexpression of EPHA1 
                         Customized lentivirus expression plasmids for stable overexpression of EPHA1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EPHA1 About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    CDC42 Pathway0.41
    Actin Nucleation and Branching0.66
    RhoA Pathway0.35
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for EPHA1
        Neurophysiological process Receptor-mediated axon growth repulsion
    Cell adhesion Ephrins signaling
    G-protein signaling RhoA regulation pathway

    5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPHA1 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway

    3 GeneGo (Thomson Reuters) Pathways for EPHA1
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    1 BioSystems Pathway for EPHA1
        EPHA forward signaling



    1         Kegg Pathway  (Kegg details for EPHA1):
        Axon guidance


    EPHA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EPHA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/24 Interacting proteins for EPHA1 (P217093 ENSP000002758154) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFNA1P208273, ENSP000003573924I2D: score=1 STRING: ENSP00000357392
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ALKQ9UM733, ENSP000003737004I2D: score=1 STRING: ENSP00000373700
    SMURF2Q9HAU43, ENSP000002624354I2D: score=2 STRING: ENSP00000262435
    CBLENSP000002640334STRING: ENSP00000264033
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001954positive regulation of cell-matrix adhesion IDA19118217
    GO:0006468protein phosphorylation ----
    GO:0006469negative regulation of protein kinase activity IDA19118217
    GO:0007166cell surface receptor signaling pathway IDA19118217

    EPHA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EPHA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EPHA1

    2 HMDB Compounds for EPHA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    8 Novoseek inferred chemical compound relationships for EPHA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 83 191 16680165 (2), 8589679 (2), 9053851 (2), 7515363 (2) (see all 99)
    nitric oxide 4.08 1 14499344 (1)
    ly294002 2.27 1 12235151 (1)
    lipid 1.96 2 20197042 (1)
    fibrinogen 0 1 14576067 (1)
    pd 98,059 0 1 12235151 (1)
    retinoic acid 0 2 12671705 (1)
    vegf 0 1 20043122 (1)

    Search CenterWatch for drugs/clinical trials and news about EPHA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EPHA1 gene: 
    NM_005232.4  

    Unigene Cluster for EPHA1:

    EPH receptor A1
    Hs.89839  [show with all ESTs]
    Unigene Representative Sequence: M18391
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000458129 ENST00000275815(uc003wcz.3) ENST00000488068 ENST00000465208
    ENST00000494989 ENST00000479459 ENST00000497891

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHA1

    Additional mRNA sequence: 

    AK290351.1 AK313263.1 BC130291.1 BC144156.1 EU826604.1 EU826605.1 M18391.1 Z27409.1 

    7 DOTS entries:

    DT.91721993  DT.100045554  DT.100664350  DT.121640668  DT.100729784  DT.91721988  DT.91827212 

    24/74 AceView cDNA sequences (see all 74):

    BM756648 BM741187 AW630929 BM741169 BM710193 AI565251 BX090074 W31887 
    BM756676 BM671614 AA777651 T29822 AI057542 AU131228 C00200 AA323650 
    W16661 AA682887 BX496012 NM_005232 BM742869 AI003571 CA433359 BF741156 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EPHA1 expression in normal human tissues (normalized intensities)      EPHA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGCTGCAG
    EPHA1 Expression
    About this image


    EPHA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 6 entries
             ESI-049   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             retinal progenitor cell e12.5   
     
     Esophagus (Gastrointestinal Tract)
             esophageal epithelium   
     
     Thyroid (Endocrine System)
             parathyroid gland   
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5

    See EPHA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EPHA1

    SOURCE GeneReport for Unigene cluster: Hs.89839

    UniProtKB/Swiss-Prot: EPHA1_HUMAN, P21709
    Tissue specificity: Overexpressed in several carcinomas

        SABiosciences Expression via Pathway-Focused PCR Array including EPHA1: 
              Multiple Sclerosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for EPHA1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Epha11 , 5 Eph receptor A11, 5 85.62(n)1
    88.22(a)1
      6 (20.65 cM)5
    138351  NM_023580.41  NP_076069.21 
     423584875 
    chicken
    (Gallus gallus)
    Aves EPHA11 EPH receptor A1 65.97(n)
    64.2(a)
      378782  NM_204360.1  NP_989691.1 
    lizard
    (Anolis carolinensis)
    Reptilia EPHA16
    Uncharacterized protein
    60(a)
    1 ↔ 1
    GL343391.1(490954-631035)
    fruit fly
    (Drosophila melanogaster)
    Insecta Eph6
    Eph receptor tyrosine kinase
    31(a)
    1 → many
    4(631310-643096)


    ENSEMBL Gene Tree for EPHA1 (if available)
    TreeFam Gene Tree for EPHA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EPHA1 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHB22  
    EPHA82  EPHA32  EPHA72  EPHA102  EPHB42  
    15 SIMAP similar genes for EPHA1 using alignment to 4 protein entries:     EPHA1_HUMAN (see all proteins):
    EPHA2    EPHA4    EPHA3    EPHA7    EPHA5    EPHB1
    EPHA6    EPHB2 variant protein    EPHB2    EPHB3    EPHA10    EPHA8
    FRK    EPHB4    EPHB6

    EPHA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/471 SNPs in EPHA1 are shown (see all 471)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0421194
    A breast pleomorphic lobular carcinoma sample4--see VAR_0421192 E K mis40--------
    rs1849695901,2
    C--143088757(+) CCAGCC/TGAGTG 2 S syn10--------
    rs2013657341,2
    C--143088779(+) TGTAGC/TGTTTC 2 H R mis11Minor allele frequency- T:0.00EU 1299
    rs2015176491,2
    --143088788(+) TCATGC/TGTATG 2 H R mis10--------
    rs18045271,2
    C,F,A,H--143088823(-) ATCCCG/ATATCG 2 /P syn1 ese330Minor allele frequency- A:0.07NS EA NA WA CSA EU 8272
    rs2002650621,2
    C--143088857(+) GCAGGC/TGAAGA 2 H R mis10--------
    rs69671171,2,4
    C,F,A,H--143088867(+) AGTCAC/TCCTGT 2 M V mis130Minor allele frequency- T:0.07NS EA NA WA CSA EU 8344
    rs1998389161,2
    --143088879(+) GGACAC/TGGGCA 1 -- int10--------
    rs1121253811,2
    C,F--143088884(+) TGGGCA/GTGTCA 1 -- int14Minor allele frequency- G:0.00CSA WA NA EU 1527
    rs624727241,2
    C,F--143088897(+) CACAGC/TGGGTA 1 -- int16Minor allele frequency- T:0.14NA WA EA EU 1615

    HapMap Linkage Disequilibrium report for EPHA1 (143087382 - 143105985 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for EPHA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv517520CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 179610    OMIM disorders: --

    20/35 diseases for EPHA1 (see all 35):    About MalaCards
    craniofrontonasal syndrome    placental insufficiency    placental abruption    pancreatic ductal adenocarcinoma
    skin cancer    eclampsia    glioblastoma    esophageal squamous cell carcinoma
    pre-eclampsia    endometrial carcinoma    colorectal cancer    osteosarcoma
    b-cell lymphomas    adenocarcinoma    esophagitis    melanoma
    retinitis    neuroblastoma    squamous cell carcinoma    cervicitis


    EPHA1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/14 Novoseek inferred disease relationships for EPHA1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 40.8 4 17260020 (1), 11146556 (1), 12351647 (1), 17049832 (1)
    cancer 32.4 21 20179713 (4), 19962662 (1), 14767510 (1), 20039322 (1) (see all 18)
    tumors 32.1 26 11146556 (2), 20043122 (2), 16862074 (2), 18366728 (2) (see all 14)
    glioblastoma 26.5 1 10064801 (1)
    metastasis 20.1 6 17260020 (1), 18797510 (1), 15561600 (1), 20179713 (1) (see all 5)
    glioma 12.2 1 15126357 (1)
    colorectal cancer 9.48 2 19277044 (2)
    breast carcinoma 1.38 1 12209731 (1)
    carcinoma squamous cell 0 2 16862074 (2)
    scar 0 1 16774788 (1)

    Genetic Association Database (GAD): EPHA1
    Human Genome Epidemiology (HuGE) Navigator: EPHA1 (3 documents)
    Tumor Gene Database (TGDB): EPHA1

    Export disorders for EPHA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EPHA1 gene, integrated from 9 sources (see all 243):
    (articles sorted by number of sources associating them with EPHA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2, 3, 9 (1997)
    2. EphA1 receptor silencing by small interfering RNA has antiangiogenic and antitumor efficacy in hepatocellular carcinoma. (PubMed id 20043122)1, 2, 9 Chen G....Yu F. (2010)
    3. EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. (PubMed id 19118217)1, 2, 9 Yamazaki T....Maru Y. (2009)
    4. Spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1. (PubMed id 18728013)1, 2, 9 Bocharov E.V....Arseniev A.S. (2008)
    5. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA 1 are associated with late-onset Alzheimer's disease. (PubMed id 21460841)1, 4 Naj A.C....Schellenberg G.D. (2011)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    8. Genomic structure of the EPHA1 receptor tyrosine kinase gene. (PubMed id 10369740)1, 2 Owshalimpur D. and Kelley M.J. (1999)
    9. A novel putative tyrosine kinase receptor encoded by the eph gene. (PubMed id 2825356)1, 2 Hirai H.... Takaku F. (1987)
    10. Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival. (PubMed id 19277044)1, 9 Herath N.I....Boyd A.W. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2041 HGNC: 3385 AceView: EPHA1 Ensembl:ENSG00000146904 euGenes: HUgn2041
    ECgene: EPHA1 Kegg: 2041 H-InvDB: EPHA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EPHA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EPHA1 gene:
    Search GeneIP for patents involving EPHA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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