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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EPHA1 Gene

protein-coding   GIFtS: 65
GCID: GC07M143087

EPH receptor A1

(Previous name: EphA1 )
(Previous symbols: EPHT, EPHT1)
 Explore 39 diseases affiliated with
EPHA1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for EPHA1    

Aliases
for EPHA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
EPH Receptor A11 2     EphA11
EPHT11 2 3 5     Ephrin Type-A Receptor 12
EPH1 2 3     Erythropoietin-Producing Hepatoma Amplified Sequence2
EPHT1 2 3     Oncogene EPH2
EPH Tyrosine Kinase 12 3     Soluble EPHA1 Variant 12
Erythropoietin-Producing Hepatoma Receptor2 3     Soluble EPHA1 Variant 22
Tyrosine-Protein Kinase Receptor EPH2 3     EPH Tyrosine Kinase3
HEpha11     EC 2.7.108
EC 2.7.10.13 8     

External Ids:    HGNC: 33851   Entrez Gene: 20412   Ensembl: ENSG000001469047   OMIM: 1796105   UniProtKB: P217093   

Export aliases for EPHA1 gene to outside databases

Previous GC identifers: GC07M141414 GC07M142482 GC07M142559 GC07M142605 GC07M142798 GC07M137425


Summaries
for EPHA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EPHA1:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors
have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH
subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2
fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their
extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed
in some human cancer cell lines and has been implicated in carcinogenesis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: EPHA1_HUMAN, P21709
Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway
downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin
ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to
EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment
to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and
RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis

Gene Wiki entry for EPHA1 (EPH receptor A1)


Genomic Views
for EPHA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EPHA1 gene promoter:
         Max1   AP-1   ATF-2   STAT3   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EPHA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for EPHA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q35   HGNC cytogenetic band: 7q32-q36

EPHA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHA1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M143087:  view genomic region     (about GC identifiers)

Start:
 143,087,382 bp from pter      End:
 143,105,985 bp from pter
Size:
 18,604 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 142,490,337-142,508,118     

Proteins
for EPHA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EPHA1_HUMAN, P21709 (See protein sequence)
Recommended Name: Ephrin type-A receptor 1 precursor  
Size: 976 amino acids; 108127 Da
Subunit: Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates
T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of
the kinase activity of EPHA1. Interacts (kinase activity-dependent) with PTK2/FAK1
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAA36747.1; Type=Frameshift; Positions=582, 595, 601;
4 PDB 3D structures from and Proteopedia for EPHA1:
2K1K (3D)        2K1L (3D)        3HIL (3D)        3KKA (3D)    
Secondary accessions: A1L3V3 Q15405

Explore the universe of human proteins at neXtProt for EPHA1: NX_P21709

Post-translational modifications:

  • Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P21709

    • 4/8 DME Specific Peptides for EPHA1 (P21709) (see all 8)
     LAQFPDT  CKETFNL  TEFMENG  RDLAARN 

    EPHA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005223.4  
    ENSEMBL proteins: 
     ENSP00000275815  

    Human Recombinant Protein Products: 
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    Novus Biologicals EPHA1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EPHA1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IDA19118217


    EPHA1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for EPHA1

    Protein Domains /
    Families
    for EPHA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EPHA1 for domains           About GeneDecksing

    5/16 InterPro domains/families (see all 16):
     IPR017441 Protein_kinase_ATP_BS
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR003961 Fibronectin_type3

    Graphical View of Domain Structure for InterPro Entry P21709

    ProtoNet protein and cluster: P21709

    2 Blocks protein families:
    IPB001660 Sterile alpha motif SAM
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHA1_HUMAN, P21709
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Function
    for EPHA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EPHA1_HUMAN, P21709
    Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway
    downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin
    ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to
    EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment
    to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and
    RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for EPHA1:
    EPH-related tyrosine kinase receptor 1,binding ephrin A1,expressed in projecting neurons and their target
    fields,involved in short-range contact-mediated axonal guidance

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPHA1
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate EPHA1 (see all 13):
    hsa-miR-520d-5p hsa-miR-15a hsa-miR-3065-3p hsa-miR-497 hsa-miR-4287 hsa-miR-211 hsa-miR-656 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: EPHA1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPHA1 (see all 7)
    OriGene shRNA RFP: EPHA1
    OriGene siRNA: EPHA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHA1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for EPHA1

    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: EPHA1 (NM_005232)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA1 

    Cell Line
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    Search LifeMap BioReagents cell lines for EPHA1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA12775584
    GO:0005005transmembrane-ephrin receptor activity IDA19118217
    GO:0005524ATP binding IEA--
    GO:0019901protein kinase binding IPI19118217


    EPHA1 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for EPHA1:
     Decreased TP53 protein express  Decreased substrate adherent c  Increased colony dispersion (i  Synthetic lethal with gemcitab 

    Animal Models:
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Epha1):
     growth/size  homeostasis/metabolism  immune system  limbs/digits/tail  reproductive system 
     skeleton 

    EPHA1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for EPHA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex1.00
    		RhoA Pathway0.35
    		Actin Nucleation and Branching0.66
    		CDC42 Pathway0.34
    4Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48
    5G-protein signaling_RhoA regulation pathway
    		G-protein signaling_RhoA regulation pathway1.00
    		EphrinA-EphR Signaling0.26
    		G-protein signaling RhoA regulation pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for EPHA1
        Neurophysiological process Receptor-mediated axon growth repulsion
    Cell adhesion Ephrins signaling
    G-protein signaling RhoA regulation pathway

    5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPHA1 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway

    3 GeneGo (Thomson Reuters) Pathways for EPHA1
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    1 BioSystems Pathway for EPHA1 
        EPHA forward signaling


    1         Kegg Pathway  (Kegg details for EPHA1):
        Axon guidance


    EPHA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EPHA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/24 Interacting proteins for EPHA1 (P217093 ENSP000002758154) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFNA1P208273, ENSP000003573924I2D: score=1 STRING: ENSP00000357392
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ALKQ9UM733, ENSP000003737004I2D: score=1 STRING: ENSP00000373700
    SMURF2Q9HAU43, ENSP000002624354I2D: score=2 STRING: ENSP00000262435
    CBLENSP000002640334STRING: ENSP00000264033
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001954positive regulation of cell-matrix adhesion IDA19118217
    GO:0006469negative regulation of protein kinase activity IDA19118217
    GO:0007166cell surface receptor signaling pathway IDA19118217
    GO:0008284positive regulation of cell proliferation IMP--


    EPHA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for EPHA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EPHA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EPHA1

    2 HMDB Compounds for EPHA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    8 Novoseek chemical compound relationships for EPHA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 83 191 16680165 (2), 8589679 (2), 9053851 (2), 7515363 (2) (see all 99)
    nitric oxide 4.08 1 14499344 (1)
    ly294002 2.27 1 12235151 (1)
    lipid 1.96 2 20197042 (1)
    fibrinogen 0 1 14576067 (1)
    pd 98,059 0 1 12235151 (1)
    retinoic acid 0 2 12671705 (1)
    vegf 0 1 20043122 (1)

    Search CenterWatch for drugs/clinical trials and news about EPHA1 

    Transcripts
    for EPHA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EPHA1 gene: 
    NM_005232.4  

    Unigene Cluster for EPHA1:

    EPH receptor A1
    Hs.89839  [show with all ESTs]
    Unigene Representative Sequence: M18391
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000458129 ENST00000275815(uc003wcz.3) ENST00000488068 ENST00000465208
    ENST00000494989 ENST00000479459 ENST00000497891

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    hsa-miR-520d-5p hsa-miR-15a hsa-miR-3065-3p hsa-miR-497 hsa-miR-4287 hsa-miR-211 hsa-miR-656 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: EPHA1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK290351.1 AK313263.1 BC130291.1 BC144156.1 EU826604.1 EU826605.1 M18391.1 Z27409.1 

    7 DOTS entries:

    DT.91721993  DT.100045554  DT.100664350  DT.121640668  DT.100729784  DT.91721988  DT.91827212 

    24/74 AceView cDNA sequences (see all 74):

    AW630929 BM671614 BM741169 BM756648 AI565251 BM741187 BX090074 BM710193 
    BM756676 W31887 W16661 AA843803 CA433359 T29822 AA323650 BM853008 
    C00200 M18391 AA777651 AU131228 BP355458 BM975549 BM742869 BX496012 

    GeneLoc Exon Structure


    Expression
    for EPHA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EPHA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGGCTGCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    EPHA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyUreteric BudKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See EPHA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EPHA1

    SOURCE GeneReport for Unigene cluster: Hs.89839

    UniProtKB/Swiss-Prot: EPHA1_HUMAN, P21709
    Tissue specificity: Overexpressed in several carcinomas

        SABiosciences Expression via Pathway-Focused PCR Array including EPHA1: 
              Multiple Sclerosis in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHA1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA1

    Orthologs
    for EPHA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for EPHA1 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves EPHA11 EPH receptor A1 65.97(n)
    64.2(a)    		   378782  NM_204360.1  NP_989691.1 
    lizard
    (Anolis carolinensis)    		 Reptilia EPHA16
    		 --
    		 61(a)
    		 1 ↔ 1
    		 GL343391.1(573938-631035)
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01084877.16
    CU570987.26
    		 --
    		 27(a)
    15(a)
    		 possible ortholog
    possible ortholog
    		 Zv9_NA779(312-23840)
    7(19322147-19328556)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Eph6
    		 Eph receptor tyrosine kinase
    		 30(a)
    		 1 → many
    		 4(631310-643096)
    worm
    (Caenorhabditis elegans)    		 Secernentea vab-16
    kin-246
    (see all 6)    		 protein KINase family member (kin-24)
    (see all 6)    		 26(a)
    19(a)
    (see all 6)    		 possible ortholog
    possible ortholog
    (see all 6)    		 II(4571997-4591357)
    IV(9839089-9841052)


    ENSEMBL Gene Tree for EPHA1 (if available)
    TreeFam Gene Tree for EPHA1 (if available) 

    Paralogs
    for EPHA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EPHA1 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHB22  
    EPHA82  EPHA32  EPHA72  EPHB42  EPHA102  
    15 SIMAP similar genes for EPHA1 using alignment to 4 protein entries:     EPHA1_HUMAN (see all proteins):
    EPHA2    EPHA4    EPHA3    EPHA7    EPHA5    EPHB1
    EPHA6    EPHB2 variant protein    EPHB2    EPHB3    EPHA10    EPHA8
    FRK    EPHB4    EPHB6

    EPHA1 for paralogs           About GeneDecksing



    Genomic Variants
    for EPHA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/458 NCBI SNPs in EPHA1 are shown (see all 458)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1824617101,2
    		C,--143087815(+) CCCCAC/TTGTGG 3 -- ut31 ds50010--------
    rs1882781481,2
    		--143087934(+) AACATA/GGTCTA 3 -- ut31 ds50010--------
    rs1401127131,2
    		--143087940(+) GTCTAA/GGGATG 3 -- ut31 ds50010--------
    rs115527441,2
    		C,--143087956(+) TCCCCG/ACCCTG 3 -- ds5001 ut313Minor allele frequency- A:0.20NA EA 242
    rs1113350841,2
    		C,--143088064(+) GCACCT/CGCGCC 3 -- ds5001 ut311Minor allele frequency- C:0.00CSA 1
    rs1441140271,2
    		--143088076(+) TCGGCC/TGGCCC 3 -- ut31 ds50010--------
    rs48591,2
    		C,F,A,--143088085(+) CCCCCA/C/G/T 
                AGCAG     		7 -- ut31 ds500110MN NA WA CSA EA 740
    rs1167261091,2
    		C,F,--143088159(+) TGCCAA/GGTTGT 3 -- ds5001 ut311Minor allele frequency- G:0.04WA 118
    rs1134197451,2
    		C--143088176(+) AGCTAA/C/GAAATA 5 -- ds5001 ut311CSA 1
    rs1854720761,2
    		--143088473(+) GGGGCA/GCAGGG 3 -- ds5001 ut310--------

    HapMap Linkage Disequilibrium report for EPHA1 (143087382 - 143105985 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for EPHA1
         3 CNVs: 52140 52138 52139

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for EPHA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EPHA1 for disorders           About GeneDecksing

    OMIM gene information: 179610    OMIM disorders: --

    20/39 diseases for EPHA1 (see all 39):    About MalaCards
    pre-eclampsia    placental abruption    placental insufficiency    b-cell lymphomas
    craniofrontonasal syndrome    esophageal squamous cell carcinoma    squamous cell carcinoma    pancreatic ductal adenocarcinoma
    eclampsia    carcinoma    embryonal carcinoma    rheumatoid arthritis
    breast carcinoma    colorectal cancer    endometrial carcinoma    skin cancer
    breast cancer    glioblastoma    cervical carcinoma    hematopoiesis

    10/14 Novoseek disease relationships for EPHA1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 40.8 4 17260020 (1), 11146556 (1), 12351647 (1), 17049832 (1)
    cancer 32.4 21 20179713 (4), 19962662 (1), 14767510 (1), 20039322 (1) (see all 18)
    tumors 32.1 26 11146556 (2), 20043122 (2), 16862074 (2), 18366728 (2) (see all 14)
    glioblastoma 26.5 1 10064801 (1)
    metastasis 20.1 6 17260020 (1), 18797510 (1), 15561600 (1), 20179713 (1) (see all 5)
    glioma 12.2 1 15126357 (1)
    colorectal cancer 9.48 2 19277044 (2)
    breast carcinoma 1.38 1 12209731 (1)
    carcinoma squamous cell 0 2 16862074 (2)
    scar 0 1 16774788 (1)

    Human Genome Epidemiology (HuGE) Navigator: EPHA1 (3 documents)
    Tumor Gene Database (TGDB): EPHA1

    Export disorders for EPHA1 gene to outside databases

    Publications
    for EPHA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EPHA1 gene, integrated from 9 sources (see all 240):
    (articles sorted by number of sources associating them with EPHA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2, 3, 9 (1997)
    2. EphA1 receptor silencing by small interfering RNA has antiangiogenic and antitumor efficacy in hepatocellular carcinoma. (PubMed id 20043122)1, 2, 9 Chen G....Yu F. (2010)
    3. EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. (PubMed id 19118217)1, 2, 9 Yamazaki T....Maru Y. (2009)
    4. Spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1. (PubMed id 18728013)1, 2, 9 Bocharov E.V....Arseniev A.S. (2008)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    6. Genomic structure of the EPHA1 receptor tyrosine kinase gene. (PubMed id 10369740)1, 2 Owshalimpur D. and Kelley M.J. (1999)
    7. A novel putative tyrosine kinase receptor encoded by the eph gene. (PubMed id 2825356)1, 2 Hirai H.... Takaku F. (1987)
    8. Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival. (PubMed id 19277044)1, 9 Herath N.I....Boyd A.W. (2009)
    9. Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancer. (PubMed id 16862074)1, 9 Hafner C....Vogt T. (2006)
    10. Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival. (PubMed id 16737551)1, 9 Herath N.I....Boyd A.W. (2006)

    External Searches for EPHA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing EPHA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2041 HGNC: 3385 AceView: EPHA1 Ensembl:ENSG00000146904 euGenes: HUgn2041
    ECgene: EPHA1 Kegg: 2041 H-InvDB: EPHA1

    Other Databases showing EPHA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing EPHA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EPHA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHA1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for EPHA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for EPHA1 gene:
    Search GeneIP for patents involving EPHA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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