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Aliases for EPHA1 Gene

Aliases for EPHA1 Gene

  • EPH Receptor A1 2 3 5
  • Erythropoietin-Producing Hepatoma Receptor 3 4
  • Tyrosine-Protein Kinase Receptor EPH 3 4
  • EC 2.7.10.1 4 61
  • HEpha1 3 4
  • EPHT1 3 4
  • EPHT 3 4
  • EPH 3 4
  • Erythropoietin-Producing Hepatoma Amplified Sequence 3
  • Ephrin Type-A Receptor 1 3
  • Soluble EPHA1 Variant 1 3
  • Soluble EPHA1 Variant 2 3
  • Eph Tyrosine Kinase 1 3
  • EPH Tyrosine Kinase 1 4
  • EPH Tyrosine Kinase 4
  • Oncogene EPH 3
  • EC 2.7.10 61
  • EphA1 2

External Ids for EPHA1 Gene

Previous HGNC Symbols for EPHA1 Gene

  • EPHT
  • EPHT1

Previous GeneCards Identifiers for EPHA1 Gene

  • GC07M141414
  • GC07M142482
  • GC07M142559
  • GC07M142605
  • GC07M142798
  • GC07M143087
  • GC07M137425

Summaries for EPHA1 Gene

Entrez Gene Summary for EPHA1 Gene

  • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for EPHA1 Gene

EPHA1 (EPH Receptor A1) is a Protein Coding gene. Diseases associated with EPHA1 include Placenta Praevia and Craniofrontonasal Dysplasia. Among its related pathways are Activation of cAMP-Dependent PKA and EPHA forward signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHA2.

UniProtKB/Swiss-Prot for EPHA1 Gene

  • Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Tocris Summary for EPHA1 Gene

  • Eph receptors are the largest family of receptor tyrosine kinases (RTKs) and are divided into two subclasses, EphA and EphB. Originally identified as mediators of axon guidance, Eph receptors are implicated in many processes, particularly cancer development and progression.

Gene Wiki entry for EPHA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHA1 Gene

Genomics for EPHA1 Gene

Regulatory Elements for EPHA1 Gene

Enhancers for EPHA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F143378 1.5 FANTOM5 Ensembl ENCODE 19.4 +22.7 22698 15.9 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A YBX1 ZNF2 YY1 ZYX EPHA1-AS1 EPHA1 CLCN1 HINT1P1 OR2A1 FAM131B LOC100507507 TAS2R60 ARHGEF35
GH07F143371 0.2 ENCODE 15.6 +36.6 36628 1.1 CTCF ZBTB48 MAX ZNF24 RAD21 MYC EPHA1 EPHA1-AS1 ZYX FAM131B LOC101928397
GH07F143330 1 Ensembl ENCODE 11.7 +77.3 77327 1.3 SMARCC1 JUND FOS NFE2L2 EPHA1 EPHA1-AS1 FAM131B LOC100507507 ZYX CLCN1 LOC101928397
GH07F143258 1.4 FANTOM5 Ensembl ENCODE 11.6 +149.6 149624 2.2 YY1 ZNF766 GATA2 CBX5 FOS SP3 JUNB NCOA1 SMARCA4 PBX2 TMEM139 LOC105375545 CASP2 RN7SL535P EPHA1 EPHA1-AS1 FAM131B HINT1P1 CLCN1 ZYX
GH07F143374 1 FANTOM5 ENCODE 11.3 +33.0 32990 3.0 MAX MYC EPHA1 EPHA1-AS1 FAM131B GSTK1 TCAF2 ZYX LOC101928397
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around EPHA1 on UCSC Golden Path with GeneCards custom track

Promoters for EPHA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001897237 292 1201 CTCF ZEB2 REST RAD21 NR2F2 CTBP1 GATA3 POLR2A SMC3 ZBTB33

Genomic Location for EPHA1 Gene

Chromosome:
7
Start:
143,390,289 bp from pter
End:
143,408,892 bp from pter
Size:
18,604 bases
Orientation:
Minus strand

Genomic View for EPHA1 Gene

Genes around EPHA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPHA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPHA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHA1 Gene

Proteins for EPHA1 Gene

  • Protein details for EPHA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21709-EPHA1_HUMAN
    Recommended name:
    Ephrin type-A receptor 1
    Protein Accession:
    P21709
    Secondary Accessions:
    • A1L3V3
    • B5A966
    • B5A967
    • Q15405

    Protein attributes for EPHA1 Gene

    Size:
    976 amino acids
    Molecular mass:
    108127 Da
    Quaternary structure:
    • Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA1. Interacts (kinase activity-dependent) with PTK2/FAK1.
    SequenceCaution:
    • Sequence=AAA36747.1; Type=Frameshift; Positions=582, 595, 601; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EPHA1 Gene

    Alternative splice isoforms for EPHA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHA1 Gene

Selected DME Specific Peptides for EPHA1 Gene

P21709:
  • RDLAARN
  • RWTAPEAI
  • LAQFPDT
  • CKETFNL
  • YVHRDLAARNILVN
  • ALVSVRV
  • LPGHQKRI
  • TEFMENG

Post-translational modifications for EPHA1 Gene

Other Protein References for EPHA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EPHA1 (EphA1)
  • Cloud-Clone Corp. Antibodies for EPHA1

Domains & Families for EPHA1 Gene

Suggested Antigen Peptide Sequences for EPHA1 Gene

Graphical View of Domain Structure for InterPro Entry

P21709

UniProtKB/Swiss-Prot:

EPHA1_HUMAN :
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Domain:
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Contains 2 fibronectin type-III domains.
  • Contains 1 protein kinase domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
genes like me logo Genes that share domains with EPHA1: view

Function for EPHA1 Gene

Molecular function for EPHA1 Gene

GENATLAS Biochemistry:
EPH-related tyrosine kinase receptor 1,binding ephrin A1,expressed in projecting neurons and their target fields,involved in short-range contact-mediated axonal guidance
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Enzyme Numbers (IUBMB) for EPHA1 Gene

Gene Ontology (GO) - Molecular Function for EPHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,IDA 12775584
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA --
GO:0005003 ephrin receptor activity IEA --
GO:0005005 transmembrane-ephrin receptor activity IDA 19118217
genes like me logo Genes that share ontologies with EPHA1: view
genes like me logo Genes that share phenotypes with EPHA1: view

Animal Models for EPHA1 Gene

MGI Knock Outs for EPHA1:

Animal Model Products

  • Taconic Biosciences Mouse Models for EPHA1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EPHA1

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPHA1 Gene

Localization for EPHA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHA1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPHA1 Gene COMPARTMENTS Subcellular localization image for EPHA1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EPHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IEA,IDA 19118217
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EPHA1: view

Pathways & Interactions for EPHA1 Gene

genes like me logo Genes that share pathways with EPHA1: view

SIGNOR curated interactions for EPHA1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EPHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001954 positive regulation of cell-matrix adhesion IDA 19118217
GO:0006468 protein phosphorylation IEA --
GO:0006469 negative regulation of protein kinase activity IDA 19118217
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with EPHA1: view

Drugs & Compounds for EPHA1 Gene

(4) Drugs for EPHA1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(6) Additional Compounds for EPHA1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with EPHA1: view

Transcripts for EPHA1 Gene

Unigene Clusters for EPHA1 Gene

EPH receptor A1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for EPHA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPHA1 Gene

No ASD Table

Relevant External Links for EPHA1 Gene

GeneLoc Exon Structure for
EPHA1
ECgene alternative splicing isoforms for
EPHA1

Expression for EPHA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EPHA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPHA1 Gene

This gene is overexpressed in Esophagus - Mucosa (x14.3), Vagina (x5.9), Skin - Sun Exposed (Lower leg) (x4.5), and Skin - Not Sun Exposed (Suprapubic) (x4.4).

Protein differential expression in normal tissues from HIPED for EPHA1 Gene

This gene is overexpressed in Serum (32.6) and Urine (26.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EPHA1 Gene



Protein tissue co-expression partners for EPHA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of EPHA1 Gene:

EPHA1

SOURCE GeneReport for Unigene cluster for EPHA1 Gene:

Hs.89839

mRNA Expression by UniProt/SwissProt for EPHA1 Gene:

P21709-EPHA1_HUMAN
Tissue specificity: Overexpressed in several carcinomas.
genes like me logo Genes that share expression patterns with EPHA1: view

Primer Products

Orthologs for EPHA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPHA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPHA1 34 35
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia EPHA1 34 35
  • 87.7 (n)
cow
(Bos Taurus)
Mammalia EPHA1 34 35
  • 86.06 (n)
mouse
(Mus musculus)
Mammalia Epha1 34 16 35
  • 85.55 (n)
rat
(Rattus norvegicus)
Mammalia Epha1 34
  • 85.28 (n)
oppossum
(Monodelphis domestica)
Mammalia EPHA1 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves EPHA1 34 35
  • 66.1 (n)
lizard
(Anolis carolinensis)
Reptilia EPHA1 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eph 35
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
ManyToMany
CSA.7809 35
  • 36 (a)
ManyToMany
CSA.1664 35
  • 35 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
Species where no ortholog for EPHA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EPHA1 Gene

ENSEMBL:
Gene Tree for EPHA1 (if available)
TreeFam:
Gene Tree for EPHA1 (if available)

Paralogs for EPHA1 Gene

genes like me logo Genes that share paralogs with EPHA1: view

Variants for EPHA1 Gene

Sequence variations from dbSNP and Humsavar for EPHA1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_042119 A breast pleomorphic lobular carcinoma sample
rs10227035 -- 143,392,202(+) TCCGG(G/T)AGCAG intron-variant
rs10808026 -- 143,402,040(+) AGTCT(A/C)CCAAG intron-variant
rs10952549 -- 143,396,445(+) GTCCA(A/G)GGCTC nc-transcript-variant, reference, synonymous-codon
rs10952550 -- 143,400,947(+) GGTGT(A/G)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPHA1 Gene

Variant ID Type Subtype PubMed ID
nsv517520 CNV loss 19592680
nsv608681 CNV loss 21841781
nsv949967 CNV deletion 24416366

Variation tolerance for EPHA1 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.05; 75.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPHA1 Gene

Human Gene Mutation Database (HGMD)
EPHA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EPHA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHA1 Gene

Disorders for EPHA1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for EPHA1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
placenta praevia
  • placenta previa
craniofrontonasal dysplasia
  • craniofrontonasal syndrome
rh isoimmunization
  • rh incompatibility affecting management of mother
uterine disease
  • uterine diseases
placenta disease
  • placenta disorder
- elite association - COSMIC cancer census association via MalaCards
Search EPHA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EPHA1

Genetic Association Database (GAD)
EPHA1
Human Genome Epidemiology (HuGE) Navigator
EPHA1
Tumor Gene Database (TGDB):
EPHA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EPHA1
genes like me logo Genes that share disorders with EPHA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EPHA1 Gene

Publications for EPHA1 Gene

  1. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PMID: 9267020) (Cell 1997) 2 3 4 22 64
  2. EphA1 receptor silencing by small interfering RNA has antiangiogenic and antitumor efficacy in hepatocellular carcinoma. (PMID: 20043122) Chen G. … Yu F. (Oncol. Rep. 2010) 3 4 22 64
  3. EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. (PMID: 19118217) Yamazaki T. … Maru Y. (J. Cell Sci. 2009) 3 4 22 64
  4. Spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1. (PMID: 18728013) Bocharov E.V. … Arseniev A.S. (J. Biol. Chem. 2008) 3 4 22 64
  5. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. (PMID: 21460841) Naj A.C. … Schellenberg G.D. (Nat. Genet. 2011) 3 46 64

Products for EPHA1 Gene

Sources for EPHA1 Gene

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