Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EPHA1 Gene

Aliases for EPHA1 Gene

  • EPH Receptor A1 2 3 5
  • Erythropoietin-Producing Hepatoma Receptor 3 4
  • Tyrosine-Protein Kinase Receptor EPH 3 4
  • EC 2.7.10.1 4 63
  • HEpha1 3 4
  • EPHT1 3 4
  • EPHT 3 4
  • EPH 3 4
  • Erythropoietin-Producing Hepatoma Amplified Sequence 3
  • Soluble EPHA1 Variant 1 3
  • Soluble EPHA1 Variant 2 3
  • Eph Tyrosine Kinase 1 3
  • EPH Tyrosine Kinase 1 4
  • EPH Tyrosine Kinase 4
  • Oncogene EPH 3
  • EC 2.7.10 63
  • EphA1 2

External Ids for EPHA1 Gene

Previous HGNC Symbols for EPHA1 Gene

  • EPHT
  • EPHT1

Previous GeneCards Identifiers for EPHA1 Gene

  • GC07M141414
  • GC07M142482
  • GC07M142559
  • GC07M142605
  • GC07M142798
  • GC07M143087
  • GC07M137425

Summaries for EPHA1 Gene

Entrez Gene Summary for EPHA1 Gene

  • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for EPHA1 Gene

EPHA1 (EPH Receptor A1) is a Protein Coding gene. Diseases associated with EPHA1 include Craniofrontonasal Dysplasia and Placenta Praevia. Among its related pathways are Axon guidance and ERK Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHA3.

UniProtKB/Swiss-Prot for EPHA1 Gene

  • Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Tocris Summary for EPHA1 Gene

Gene Wiki entry for EPHA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHA1 Gene

Genomics for EPHA1 Gene

Regulatory Elements for EPHA1 Gene

Enhancers for EPHA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EPHA1 on UCSC Golden Path with GeneCards custom track

Promoters for EPHA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EPHA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for EPHA1 Gene

Chromosome:
7
Start:
143,390,289 bp from pter
End:
143,408,892 bp from pter
Size:
18,604 bases
Orientation:
Minus strand

Genomic View for EPHA1 Gene

Genes around EPHA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPHA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPHA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHA1 Gene

Proteins for EPHA1 Gene

  • Protein details for EPHA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21709-EPHA1_HUMAN
    Recommended name:
    Ephrin type-A receptor 1
    Protein Accession:
    P21709
    Secondary Accessions:
    • A1L3V3
    • B5A966
    • B5A967
    • Q15405

    Protein attributes for EPHA1 Gene

    Size:
    976 amino acids
    Molecular mass:
    108127 Da
    Quaternary structure:
    • Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA1. Interacts (kinase activity-dependent) with PTK2/FAK1.
    SequenceCaution:
    • Sequence=AAA36747.1; Type=Frameshift; Positions=582, 595, 601; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EPHA1 Gene

    Alternative splice isoforms for EPHA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHA1 Gene

Proteomics data for EPHA1 Gene at MOPED

Selected DME Specific Peptides for EPHA1 Gene

Post-translational modifications for EPHA1 Gene

Other Protein References for EPHA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for EPHA1 Gene

Suggested Antigen Peptide Sequences for EPHA1 Gene

Graphical View of Domain Structure for InterPro Entry

P21709

UniProtKB/Swiss-Prot:

EPHA1_HUMAN :
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Domain:
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Contains 2 fibronectin type-III domains.
  • Contains 1 protein kinase domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
genes like me logo Genes that share domains with EPHA1: view

Function for EPHA1 Gene

Molecular function for EPHA1 Gene

GENATLAS Biochemistry:
EPH-related tyrosine kinase receptor 1,binding ephrin A1,expressed in projecting neurons and their target fields,involved in short-range contact-mediated axonal guidance
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Enzyme Numbers (IUBMB) for EPHA1 Gene

Gene Ontology (GO) - Molecular Function for EPHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA --
GO:0019901 protein kinase binding IPI 19118217
genes like me logo Genes that share ontologies with EPHA1: view
genes like me logo Genes that share phenotypes with EPHA1: view

Animal Models for EPHA1 Gene

MGI Knock Outs for EPHA1:

Animal Model Products

  • Taconic Biosciences Mouse Models for EPHA1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPHA1 Gene

Localization for EPHA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHA1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPHA1 Gene COMPARTMENTS Subcellular localization image for EPHA1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for EPHA1 Gene

Pathways & Interactions for EPHA1 Gene

genes like me logo Genes that share pathways with EPHA1: view

SIGNOR curated interactions for EPHA1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EPHA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007411 axon guidance TAS --
GO:0018108 peptidyl-tyrosine phosphorylation IDA 12775584
GO:0030335 positive regulation of cell migration IMP 20043122
GO:0030336 negative regulation of cell migration IDA 19118217
genes like me logo Genes that share ontologies with EPHA1: view

Drugs & Compounds for EPHA1 Gene

(4) Drugs for EPHA1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(6) Additional Compounds for EPHA1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with EPHA1: view

Transcripts for EPHA1 Gene

Unigene Clusters for EPHA1 Gene

EPH receptor A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPHA1 Gene

No ASD Table

Relevant External Links for EPHA1 Gene

GeneLoc Exon Structure for
EPHA1
ECgene alternative splicing isoforms for
EPHA1

Expression for EPHA1 Gene

mRNA expression in normal human tissues for EPHA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPHA1 Gene

This gene is overexpressed in Esophagus - Mucosa (x14.3), Vagina (x5.9), Skin - Sun Exposed (Lower leg) (x4.5), and Skin - Not Sun Exposed (Suprapubic) (x4.4).

Protein differential expression in normal tissues from HIPED for EPHA1 Gene

This gene is overexpressed in Serum (32.6) and Urine (26.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EPHA1 Gene



SOURCE GeneReport for Unigene cluster for EPHA1 Gene Hs.89839

mRNA Expression by UniProt/SwissProt for EPHA1 Gene

P21709-EPHA1_HUMAN
Tissue specificity: Overexpressed in several carcinomas.
genes like me logo Genes that share expression patterns with EPHA1: view

Protein tissue co-expression partners for EPHA1 Gene

Primer Products

Orthologs for EPHA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPHA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EPHA1 35
  • 86.06 (n)
  • 87.95 (a)
EPHA1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPHA1 35
  • 87.7 (n)
  • 90.27 (a)
EPHA1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Epha1 35
  • 85.55 (n)
  • 88.01 (a)
Epha1 16
Epha1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EPHA1 35
  • 99.28 (n)
  • 99.28 (a)
EPHA1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Epha1 35
  • 85.28 (n)
  • 88.01 (a)
oppossum
(Monodelphis domestica)
Mammalia EPHA1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves EPHA1 35
  • 66.1 (n)
  • 64.19 (a)
EPHA1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPHA1 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eph 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
CSA.1664 36
  • 35 (a)
ManyToMany
CSA.7809 36
  • 36 (a)
ManyToMany
Species with no ortholog for EPHA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EPHA1 Gene

ENSEMBL:
Gene Tree for EPHA1 (if available)
TreeFam:
Gene Tree for EPHA1 (if available)

Paralogs for EPHA1 Gene

Paralogs for EPHA1 Gene

genes like me logo Genes that share paralogs with EPHA1: view

Variants for EPHA1 Gene

Sequence variations from dbSNP and Humsavar for EPHA1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs4725617 - 143,400,007(+) CAGAC(A/G)CAAGG nc-transcript-variant, reference, missense
rs11768549 - 143,398,060(+) GGTAC(C/T)GTTCT nc-transcript-variant, reference, missense
rs6967117 - 143,391,774(+) AGTCA(C/T)CCTGT nc-transcript-variant, reference, missense
rs56006153 - 143,398,886(+) CCAAC(A/G)CAGGG intron-variant, nc-transcript-variant, reference, missense
rs35719334 - 143,397,351(+) TCTGC(C/T)GCTGG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for EPHA1 Gene

Variant ID Type Subtype PubMed ID
nsv517520 CNV Loss 19592680

Variation tolerance for EPHA1 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.05; 75.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPHA1 Gene

Human Gene Mutation Database (HGMD)
EPHA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHA1 Gene

Disorders for EPHA1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for EPHA1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
craniofrontonasal dysplasia
  • craniofrontonasal syndrome
placenta praevia
  • placenta previa
asphyxia neonatorum
  • asphyxia - birth
rh isoimmunization
  • rh incompatibility affecting management of mother
uterine disease
  • uterine diseases
- elite association - COSMIC cancer census association via MalaCards
Search EPHA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EPHA1

Genetic Association Database (GAD)
EPHA1
Human Genome Epidemiology (HuGE) Navigator
EPHA1
Tumor Gene Database (TGDB):
EPHA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EPHA1
genes like me logo Genes that share disorders with EPHA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EPHA1 Gene

Publications for EPHA1 Gene

  1. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PMID: 9267020) (Cell 1997) 2 3 4 23 67
  2. EphA1 receptor silencing by small interfering RNA has antiangiogenic and antitumor efficacy in hepatocellular carcinoma. (PMID: 20043122) Chen G. … Yu F. (Oncol. Rep. 2010) 3 23
  3. EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. (PMID: 19118217) Yamazaki T. … Maru Y. (J. Cell Sci. 2009) 3 23
  4. Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival. (PMID: 19277044) Herath N.I. … Boyd A.W. (Br. J. Cancer 2009) 3 23
  5. Transmembrane domain of EphA1 receptor forms dimers in membrane-like environment. (PMID: 18590698) Artemenko E.O. … Feofanov A.V. (Biochim. Biophys. Acta 2008) 3 23

Products for EPHA1 Gene

Sources for EPHA1 Gene

Content