Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



EPHA1 Gene

protein-coding   GIFtS: 70
GCID: GC07M143087

EPH Receptor A1

(Previous name: EphA1)
(Previous symbols: EPHT, EPHT1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
EPH Receptor A11 2     EphA11
EPHT11 2 3 5     Ephrin Type-A Receptor 12
EPHT1 2 3     Erythropoietin-Producing Hepatoma Amplified Sequence2
EPH Tyrosine Kinase 12 3     Oncogene EPH2
Erythropoietin-Producing Hepatoma Receptor2 3     Soluble EPHA1 Variant 12
Tyrosine-Protein Kinase Receptor EPH2 3     Soluble EPHA1 Variant 22
EPH2 3     EPH Tyrosine Kinase3
hEpha12 3     EC 2.7.108
EC 2.7.10.13 8     

External Ids:    HGNC: 33851   Entrez Gene: 20412   Ensembl: ENSG000001469047   OMIM: 1796105   UniProtKB: P217093   

Export aliases for EPHA1 gene to outside databases

Previous GC identifers: GC07M141414 GC07M142482 GC07M142559 GC07M142605 GC07M142798 GC07M137425


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for EPHA1 Gene:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related
receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors
in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich
domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity
of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene
is expressed in some human cancer cell lines and has been implicated in carcinogenesis. (provided by RefSeq, Jul
2008)

GeneCards Summary for EPHA1 Gene:
EPHA1 (EPH receptor A1) is a protein-coding gene. GO annotations related to this gene include transmembrane-ephrin receptor activity and protein kinase binding. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHA1_HUMAN, P21709
Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high
affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces
cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and
downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in
apoptosis

Gene Wiki entry for EPHA1 (EPH receptor A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EPHA1 gene promoter:
         Max1   AP-1   ATF-2   STAT3   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPHA1 promoter sequence
   Search Chromatin IP Primers for EPHA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q35   HGNC cytogenetic band: 7q32-q36

EPHA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHA1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M143087:  view genomic region     (about GC identifiers)

Start:
143,087,382 bp from pter      End:
143,105,985 bp from pter
Size:
18,604 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 142,490,337-142,508,118     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: EPHA1_HUMAN, P21709 (See protein sequence)
Recommended Name: Ephrin type-A receptor 1 precursor  
Size: 976 amino acids; 108127 Da
Subunit: Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1;
regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but
independent of the kinase activity of EPHA1. Interacts (kinase activity-dependent) with PTK2/FAK1
Sequence caution: Sequence=AAA36747.1; Type=Frameshift; Positions=582, 595, 601;
4 PDB 3D structures from and Proteopedia for EPHA1:
2K1K (3D)        2K1L (3D)        3HIL (3D)        3KKA (3D)    
Secondary accessions: A1L3V3 Q15405

Explore the universe of human proteins at neXtProt for EPHA1: NX_P21709

Explore proteomics data for EPHA1 at MOPED

Post-translational modifications: 

  • Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA11
  • Ubiquitinated1
  • Glycosylation2 at Asn414
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for EPHA1 (P21709) (see all 8)
     LAQFPDT  CKETFNL  TEFMENG  RDLAARN 


    See EPHA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005223.4  
    ENSEMBL proteins: 
     ENSP00000275815  
    Reactome Protein details: P21709

    EPHA1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant EPHA1 Protein
    R&D Systems Recombinant & Natural Proteins for EPHA1
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for EPHA1
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for EPHA1
    OriGene Custom Protein Services for EPHA1
    GenScript Custom Purified and Recombinant Proteins Services for EPHA1
    Novus Biologicals EPHA1 Protein
    Sino Biological Recombinant Protein for EPHA1
    Sino Biological Cell Lysate for EPHA1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EPHA1

     
    Search eBioscience for Proteins for EPHA1 

    EPHA1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for EPHA1
    OriGene Antibodies for EPHA1
    OriGene Custom Antibody Services for EPHA1
    Novus Biologicals EPHA1 Antibodies
    Abcam antibodies for EPHA1
    Cloud-Clone Corp. Antibodies for EPHA1
    ThermoFisher Antibodies for EPHA1
    LSBio Antibodies in human, mouse, rat for EPHA1

    EPHA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EPHA1
    R&D Systems ELISAs for EPHA1         (see all)
    GenScript EPHA1-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EPHA1
    Cloud-Clone Corp. CLIAs for EPHA1
    Search eBioscience for ELISAs for EPHA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor A1
    Ephrin receptor family
    Ephrin receptor family

    Selected InterPro protein domains (see all 17):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR021129 SAM_type1
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P21709

    ProtoNet protein and cluster: P21709

    2 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHA1_HUMAN, P21709
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with EPHA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHA1_HUMAN, P21709
    Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high
    affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces
    cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and
    downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in
    apoptosis
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for EPHA1:
    EPH-related tyrosine kinase receptor 1,binding ephrin A1,expressed in projecting neurons and their target
    fields,involved in short-range contact-mediated axonal guidance

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA12775584
    GO:0004713protein tyrosine kinase activity ----
    GO:0005003ephrin receptor activity ----
    GO:0005005transmembrane-ephrin receptor activity IDA19118217
    GO:0005515protein binding ----
         
    Find genes that share ontologies with EPHA1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for EPHA1:
     Decreased TP53 protein express  Decreased substrate adherent c  Increased colony dispersion (i  Synthetic lethal with gemcitab 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Epha1):
     growth/size/body  homeostasis/metabolism  immune system  limbs/digits/tail  reproductive system 
     skeleton 

    Find genes that share phenotypes with EPHA1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EPHA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EPHA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPHA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPHA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target EPHA1:
    hsa-mir-335-5p (MIRT017674)

    Block miRNA regulation of human, mouse, rat EPHA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EPHA1 (see all 13):
    hsa-miR-520d-5p hsa-miR-15a hsa-miR-3065-3p hsa-miR-497 hsa-miR-4287 hsa-miR-211 hsa-miR-656 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidEPHA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EPHA1
    Predesigned siRNA for gene silencing in human, mouse, rat EPHA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EPHA1

    Clone
    Products:
         
    OriGene clones in human, mouse for EPHA1 (see all 9)
    OriGene ORF clones in mouse, rat for EPHA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EPHA1 (NM_005232)
    Sino Biological Human cDNA Clone for EPHA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA1
    Addgene plasmids for EPHA1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EPHA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for EPHA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    EPHA1_HUMAN, P21709: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    cytosol1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IDA19118217

    Find genes that share ontologies with EPHA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for EPHA1 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71


    Find genes that share SuperPaths with EPHA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EPHA1 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway

    3 GeneGo (Thomson Reuters) Pathways for EPHA1
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    1 BioSystems Pathway for EPHA1
        EPHA forward signaling


    1 Reactome Pathway for EPHA1
        POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation


    1 Kegg Pathway  (Kegg details for EPHA1):
        Axon guidance

        Pathway & Disease-focused RT2 Profiler PCR Array including EPHA1: 
              Multiple Sclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EPHA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EPHA1 (P217093 ENSP000002758154) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFNA1P208273, ENSP000003573924I2D: score=1 STRING: ENSP00000357392
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ALKQ9UM733, ENSP000003737004I2D: score=1 STRING: ENSP00000373700
    SMURF2Q9HAU43, ENSP000002624354I2D: score=2 STRING: ENSP00000262435
    CBLENSP000002640334STRING: ENSP00000264033
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001954positive regulation of cell-matrix adhesion IDA19118217
    GO:0006468protein phosphorylation ----
    GO:0006469negative regulation of protein kinase activity IDA19118217
    GO:0007166cell surface receptor signaling pathway IDA19118217

    Find genes that share ontologies with EPHA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EPHA1

    2 HMDB Compounds for EPHA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    8 Novoseek inferred chemical compound relationships for EPHA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 83 191 16680165 (2), 8589679 (2), 9053851 (2), 7515363 (2) (see all 99)
    nitric oxide 4.08 1 14499344 (1)
    ly294002 2.27 1 12235151 (1)
    lipid 1.96 2 20197042 (1)
    fibrinogen 0 1 14576067 (1)
    pd 98,059 0 1 12235151 (1)
    retinoic acid 0 2 12671705 (1)
    vegf 0 1 20043122 (1)



    Find genes that share compounds with EPHA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for EPHA1 gene: 
    NM_005232.4  

    Unigene Cluster for EPHA1:

    EPH receptor A1
    Hs.89839  [show with all ESTs]
    Unigene Representative Sequence: M18391
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000458129 ENST00000275815(uc003wcz.3) ENST00000488068 ENST00000465208
    ENST00000494989 ENST00000479459 ENST00000497891
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EPHA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EPHA1 (see all 13):
    hsa-miR-520d-5p hsa-miR-15a hsa-miR-3065-3p hsa-miR-497 hsa-miR-4287 hsa-miR-211 hsa-miR-656 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidEPHA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EPHA1
    Predesigned siRNA for gene silencing in human, mouse, rat EPHA1
    Clone
    Products:
         
    OriGene clones in human, mouse for EPHA1 (see all 9)
    OriGene ORF clones in mouse, rat for EPHA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EPHA1 (NM_005232)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA1
    Addgene plasmids for EPHA1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for EPHA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EPHA1
      QuantiTect SYBR Green Assays in human, mouse, rat EPHA1
      QuantiFast Probe-based Assays in human, mouse, rat EPHA1

    Additional mRNA sequence: 

    AK290351.1 AK313263.1 BC130291.1 BC144156.1 EU826604.1 EU826605.1 M18391.1 Z27409.1 

    7 DOTS entries:

    DT.91721993  DT.100045554  DT.100664350  DT.121640668  DT.100729784  DT.91721988  DT.91827212 

    Selected AceView cDNA sequences (see all 74):

    BM756648 AW630929 BX090074 BM756676 W31887 AI565251 BM741187 BM741169 
    BM671614 BM710193 C00200 NM_005232 W16661 AA843803 BM853008 AI057542 
    T29822 BM742869 AA682887 BX496012 AI003571 BM975549 AU131228 CA433359 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    EPHA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGCTGCAG
    EPHA1 Expression
    About this image


    EPHA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Eye (Sensory Organs)
             Retina
     
     Esophagus (Gastrointestinal Tract)
    EPHA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EPHA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.89839

    UniProtKB/Swiss-Prot: EPHA1_HUMAN, P21709
    Tissue specificity: Overexpressed in several carcinomas

        Pathway & Disease-focused RT2 Profiler PCR Array including EPHA1: 
              Multiple Sclerosis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for EPHA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EPHA1
    QuantiTect SYBR Green Assays in human, mouse, rat EPHA1
    QuantiFast Probe-based Assays in human, mouse, rat EPHA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for EPHA1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Epha11 , 5 Eph receptor A11, 5 85.55(n)1
    88.01(a)1
      6 (20.65 cM)5
    138351  NM_023580.41  NP_076069.21 
     423584875 
    chicken
    (Gallus gallus)
    Aves EPHA11 EPH receptor A1 66.1(n)
    64.19(a)
      378782  NM_204360.2  NP_989691.1 
    lizard
    (Anolis carolinensis)
    Reptilia EPHA16
    EPH receptor A1
    59(a)
    1 ↔ 1
    GL343391.1(490954-631035)
    fruit fly
    (Drosophila melanogaster)
    Insecta Eph6
    Eph receptor tyrosine kinase
    33(a)
    1 → many
    4(631310-643096)


    ENSEMBL Gene Tree for EPHA1 (if available)
    TreeFam Gene Tree for EPHA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for EPHA1 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHB22  
    EPHA82  EPHA32  EPHA72  EPHA102  EPHB42  
    15 SIMAP similar genes for EPHA1 using alignment to 4 protein entries:     EPHA1_HUMAN (see all proteins):
    EPHA2    EPHA4    EPHA3    EPHA7    EPHA5    EPHB1
    EPHA6    EPHB2 variant protein    EPHB2    EPHB3    EPHA10    EPHA8
    FRK    EPHB4    EPHB6

    Find genes that share paralogs with EPHA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for EPHA1 (see all 471)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0421194
    A breast pleomorphic lobular carcinoma sample4--see VAR_0421192 E K mis40--------
    rs1849695901,2
    C--143088757(+) CCAGCC/TGAGTG 2 S syn10--------
    rs2013657341,2
    C--143088779(+) TGTAGC/TGTTTC 2 H R mis11Minor allele frequency- T:0.00EU 1299
    rs2015176491,2
    --143088788(+) TCATGC/TGTATG 2 H R mis10--------
    rs18045271,2
    C,F,A,H--143088823(-) ATCCCG/ATATCG 2 /P syn1 ese330Minor allele frequency- A:0.07NS EA NA WA CSA EU 8272
    rs2002650621,2
    C--143088857(+) GCAGGC/TGAAGA 2 H R mis10--------
    rs69671171,2,,4
    C,F,A,H--143088867(+) AGTCAC/TCCTGT 2 M V mis130Minor allele frequency- T:0.07NS EA NA WA CSA EU 8344
    rs1998389161,2
    --143088879(+) GGACAC/TGGGCA 1 -- int10--------
    rs1121253811,2
    C,F--143088884(+) TGGGCA/GTGTCA 1 -- int14Minor allele frequency- G:0.00CSA WA NA EU 1527
    rs624727241,2
    C,F--143088897(+) CACAGC/TGGGTA 1 -- int16Minor allele frequency- T:0.14NA WA EA EU 1615

    HapMap Linkage Disequilibrium report for EPHA1 (143087382 - 143105985 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for EPHA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv517520CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EPHA1
    DNA2.0 Custom Variant and Variant Library Synthesis for EPHA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 179610    OMIM disorders: --


    Find genes that share disorders with EPHA1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for EPHA1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 40.8 4 17260020 (1), 11146556 (1), 12351647 (1), 17049832 (1)
    cancer 32.4 21 20179713 (4), 19962662 (1), 14767510 (1), 20039322 (1) (see all 18)
    tumors 32.1 26 11146556 (2), 20043122 (2), 16862074 (2), 18366728 (2) (see all 14)
    glioblastoma 26.5 1 10064801 (1)
    metastasis 20.1 6 17260020 (1), 18797510 (1), 15561600 (1), 20179713 (1) (see all 5)
    glioma 12.2 1 15126357 (1)
    colorectal cancer 9.48 2 19277044 (2)
    breast carcinoma 1.38 1 12209731 (1)
    carcinoma squamous cell 0 2 16862074 (2)
    scar 0 1 16774788 (1)

    Genetic Association Database (GAD): EPHA1
    Human Genome Epidemiology (HuGE) Navigator: EPHA1 (3 documents)
    Tumor Gene Database (TGDB): EPHA1

    Export disorders for EPHA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for EPHA1 gene, integrated from 10 sources (see all 243):
    (articles sorted by number of sources associating them with EPHA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2, 3, 9 (Cell 1997)
    2. EphA1 receptor silencing by small interfering RNA has antiangiogenic and antitumor efficacy in hepatocellular carcinoma. (PubMed id 20043122)1, 2, 9 Chen G.... Yu F. (Oncol. Rep. 2010)
    3. EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. (PubMed id 19118217)1, 2, 9 Yamazaki T.... Maru Y. (J. Cell Sci. 2009)
    4. Spatial structure and pH-dependent conformational diversity of dimeric transmembrane domain of the receptor tyrosine kinase EphA1. (PubMed id 18728013)1, 2, 9 Bocharov E.V....Arseniev A.S. (J. Biol. Chem. 2008)
    5. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. (PubMed id 21460841)1, 4 Naj A.C....Schellenberg G.D. (Nat. Genet. 2011)
    6. Development and validation of a method for profiling post-translational modification activities using protein microarrays. (PubMed id 20596523)1, 2 Del RincA^n S.V....Spruck C. (PLoS ONE 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    9. Genomic structure of the EPHA1 receptor tyrosine kinase gene. (PubMed id 10369740)1, 2 Owshalimpur D. and Kelley M.J. (Mol. Cell. Probes 1999)
    10. A novel putative tyrosine kinase receptor encoded by the eph gene. (PubMed id 2825356)1, 2 Hirai H.... Takaku F. (Science 1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2041 HGNC: 3385 AceView: EPHA1 Ensembl:ENSG00000146904 euGenes: HUgn2041
    ECgene: EPHA1 Kegg: 2041 H-InvDB: EPHA1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for EPHA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for EPHA1 gene:
    Search GeneIP for patents involving EPHA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     EMD Millipore Purified and/or Recombinant EPHA1 Protein
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for EPHA1 (EphA1)   Browse Cell Culture Products  
     ELISAs for EPHA1 (EphA1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for EPHA1 (EphA1)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for EPHA1 (EphA1)  
     OriGene Antibodies for EPHA1   OriGene RNAi products in human, mouse, rat for EPHA1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for EPHA1   OriGene clones in human, mouse for EPHA1  
     OriGene qSTAR qPCR primer pairs in human, mouse for EPHA1   OriGene Purified Protein for EPHA1  
     OriGene ORF clones in mouse, rat for EPHA1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EPHA1   OriGene Custom Protein Services for EPHA1  

     
     
     Block miRNA regulation of human, mouse, rat EPHA1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing EPHA1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHA1 Predesigned siRNA for gene silencing in human, mouse, rat EPHA1
     QuantiFast Probe-based Assays in human, mouse, rat EPHA1 QuantiTect SYBR Green Assays in human, mouse, rat EPHA1
     PCR Arrays including human, mouse, rat EPHA1 Search Chromatin IP Primers for EPHA1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EPHA1  GeneGlobe Interaction Network for EPHA1
     Regulatory tfbs in EPHA1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for EPHA1 GenScript cDNA clones with any tag delivered in your preferred vector for EPHA1
     GenScript EPHA1-Activity-based Kinase Assay for Compound Screening GenScript Custom overexpressing Cell Line Services for EPHA1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for EPHA1
     Proteins for EPHA1
     Cell Lysates for EPHA1
     cDNA Clones for EPHA1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     EPHA1 antibodies
     EPHA1 proteins
     Antibodies for EPHA1
     See all of Abcam's Antibodies, Kits and Proteins for EPHA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for EPHA1
     Antibodies for EPHA1
     ELISAs for EPHA1
     CLIAs for EPHA1



     Browse ESI BIO Cell Lines and PureStem Progenitors for EPHA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA1
     SwitchGear 3'UTR luciferase reporter plasmids for EPHA1
     SwitchGear Promoter luciferase reporter plasmids for EPHA1
     ThermoFisher Antibodies for EPHA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EPHA1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EPHA1
     LSBio Antibodies in human, mouse, rat for EPHA1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for EPHA1
      Search eBioscience for proteins for EPHA1
      Search eBioscience for elisas for EPHA1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EPHA1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4