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Aliases for EPGN Gene

Aliases for EPGN Gene

  • Epithelial Mitogen 2 3 4 5
  • EPG 3 4
  • Epithelial Mitogen Homolog (Mouse) 2
  • Epithelial Mitogen Homolog 3
  • ALGV3072 3
  • PRO9904 3
  • Epigen 3

External Ids for EPGN Gene

Previous GeneCards Identifiers for EPGN Gene

  • GC04P075540
  • GC04P075394
  • GC04P075174
  • GC04P070985

Summaries for EPGN Gene

Entrez Gene Summary for EPGN Gene

  • The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for EPGN Gene

EPGN (Epithelial Mitogen) is a Protein Coding gene. Diseases associated with EPGN include Metagonimiasis and Trichostrongylosis. GO annotations related to this gene include growth factor activity and epidermal growth factor receptor binding.

UniProtKB/Swiss-Prot for EPGN Gene

  • Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPGN Gene

Genomics for EPGN Gene

Regulatory Elements for EPGN Gene

Enhancers for EPGN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F074205 1.5 FANTOM5 Ensembl ENCODE 11 -101.3 -101257 3.8 TBP HDAC1 ATF1 TBL1XR1 ZBTB40 CREM EGR2 MEF2D KLF16 SMARCA4 EREG CXCL8 CXCL2 CXCL3 EPGN MTHFD2L GC04P074159
GH04F074202 1 ENCODE 11 -106.0 -106032 0.2 PKNOX1 MLX ARID4B FEZF1 DMAP1 SP5 MXD4 MIER2 ZNF488 PPARG EPGN GC04P074159
GH04F074373 1.1 Ensembl ENCODE 9.9 +67.7 67719 4.3 SIN3A RAD21 CHAMP1 RCOR1 FOS ELK4 ZNF362 ZNF654 SMAD5 CEBPB EPGN AREG EREG ENSG00000250532
GH04F074283 0.9 Ensembl ENCODE 11.6 -24.3 -24329 1.9 SCRT1 ZNF146 SIN3A BRCA1 JUND GATA3 SCRT2 HMBOX1 FOS RCOR1 EPGN EREG CXCL2 GC04P074159
GH04F074229 0.9 FANTOM5 Ensembl 10.9 -78.8 -78790 1.0 CTCF ZNF654 TRIM22 REST RAD21 CHAMP1 KLF16 HMBOX1 SMC3 ZNF143 EPGN CXCL8 EREG CXCL2 CXCL3 MTHFD2L GC04P074159
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EPGN on UCSC Golden Path with GeneCards custom track

Promoters for EPGN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001242941 430 200 GTF2F1 TAF1 TCF7L2

Genomic Location for EPGN Gene

Chromosome:
4
Start:
74,308,270 bp from pter
End:
74,317,298 bp from pter
Size:
9,029 bases
Orientation:
Plus strand

Genomic View for EPGN Gene

Genes around EPGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPGN Gene

Proteins for EPGN Gene

  • Protein details for EPGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW88-EPGN_HUMAN
    Recommended name:
    Epigen
    Protein Accession:
    Q6UW88
    Secondary Accessions:
    • A1BMM3
    • A1BMM4
    • A1BMM5
    • A1BMM6
    • A1BMM7
    • A1BMM8
    • A8K090

    Protein attributes for EPGN Gene

    Size:
    154 amino acids
    Molecular mass:
    17091 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EPGN Gene

neXtProt entry for EPGN Gene

Post-translational modifications for EPGN Gene

  • Glycosylation at Asn 37 and Asn 41
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EPGN Gene

Domains & Families for EPGN Gene

Protein Domains for EPGN Gene

Suggested Antigen Peptide Sequences for EPGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UW88

UniProtKB/Swiss-Prot:

EPGN_HUMAN :
  • Contains 1 EGF-like domain.
Domain:
  • Contains 1 EGF-like domain.
genes like me logo Genes that share domains with EPGN: view

No data available for Gene Families for EPGN Gene

Function for EPGN Gene

Molecular function for EPGN Gene

UniProtKB/Swiss-Prot Function:
Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.

Gene Ontology (GO) - Molecular Function for EPGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005154 epidermal growth factor receptor binding IDA 15611079
GO:0008083 growth factor activity IDA 15611079
genes like me logo Genes that share ontologies with EPGN: view
genes like me logo Genes that share phenotypes with EPGN: view

Animal Models for EPGN Gene

MGI Knock Outs for EPGN:

Animal Model Products

  • Taconic Biosciences Mouse Models for EPGN

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPGN Gene

Localization for EPGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPGN Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 2: Membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.
Isoform 4: Secreted.
Isoform 5: Secreted.
Isoform 6: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EPGN gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for EPGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005622 intracellular IEA --
GO:0005887 integral component of plasma membrane IDA 15611079
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with EPGN: view

Pathways & Interactions for EPGN Gene

No Data Available

Interacting Proteins for EPGN Gene

Selected Interacting proteins: Q6UW88-EPGN_HUMAN for EPGN Gene via IID

Symbol External ID(s) Details
EGFR
TGFA

SIGNOR curated interactions for EPGN Gene

Activates:

Gene Ontology (GO) - Biological Process for EPGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000187 activation of MAPK activity ISS --
GO:0001525 angiogenesis IDA 15611079
GO:0008284 positive regulation of cell proliferation IDA 15611079
GO:0043406 positive regulation of MAP kinase activity IDA 15611079
genes like me logo Genes that share ontologies with EPGN: view

No data available for Pathways by source for EPGN Gene

Transcripts for EPGN Gene

mRNA/cDNA for EPGN Gene

Unigene Clusters for EPGN Gene

Epithelial mitogen:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPGN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: -
SP3: - -

Relevant External Links for EPGN Gene

GeneLoc Exon Structure for
EPGN
ECgene alternative splicing isoforms for
EPGN

Expression for EPGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EPGN Gene

mRNA differential expression in normal tissues according to GTEx for EPGN Gene

This gene is overexpressed in Esophagus - Mucosa (x27.7), Vagina (x5.5), and Minor Salivary Gland (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of EPGN Gene:

EPGN

SOURCE GeneReport for Unigene cluster for EPGN Gene:

Hs.401237
genes like me logo Genes that share expression patterns with EPGN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for EPGN Gene

Orthologs for EPGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for EPGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPGN 34 35
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia EPGN 34 35
  • 90.73 (n)
dog
(Canis familiaris)
Mammalia EPGN 34 35
  • 89.62 (n)
mouse
(Mus musculus)
Mammalia Epgn 34 16 35
  • 81.63 (n)
rat
(Rattus norvegicus)
Mammalia Epgn 34
  • 78.15 (n)
oppossum
(Monodelphis domestica)
Mammalia EPGN 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EPGN 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves EPGN 34 35
  • 66.44 (n)
lizard
(Anolis carolinensis)
Reptilia EPGN 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia epgn 34
  • 56.57 (n)
Species where no ortholog for EPGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EPGN Gene

ENSEMBL:
Gene Tree for EPGN (if available)
TreeFam:
Gene Tree for EPGN (if available)

Paralogs for EPGN Gene

(3) SIMAP similar genes for EPGN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EPGN: view

No data available for Paralogs for EPGN Gene

Variants for EPGN Gene

Sequence variations from dbSNP and Humsavar for EPGN Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10586282 -- 74,310,484(+) AAAAA(-/AA)GAAGA intron-variant
rs111248354 -- 74,312,503(+) AAAAA(C/T)ATGGT intron-variant
rs111663270 -- 74,305,761(+) TTCCT(A/C/G)TAAAG intron-variant, upstream-variant-2KB
rs111667469 -- 74,309,194(+) TCTTC(C/T)CATTT intron-variant
rs111868078 -- 74,316,061(+) ATCTT(C/T)TACAA intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EPGN Gene

Variant ID Type Subtype PubMed ID
nsv1009099 CNV gain 25217958
nsv525980 CNV gain 19592680

Variation tolerance for EPGN Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EPGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPGN Gene

Disorders for EPGN Gene

MalaCards: The human disease database

(9) MalaCards diseases for EPGN Gene - From: DISEASES

Disorder Aliases PubMed IDs
metagonimiasis
  • infection by metagonimus yokogawai
trichostrongylosis
  • infection by trichostrongylus
dicrocoeliasis
  • disease due to dicrocoeliidae
trichostrongyloidiasis
capillariasis
  • capillaria infection
- elite association - COSMIC cancer census association via MalaCards
Search EPGN in MalaCards View complete list of genes associated with diseases

Relevant External Links for EPGN

Genetic Association Database (GAD)
EPGN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EPGN
genes like me logo Genes that share disorders with EPGN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EPGN Gene

Publications for EPGN Gene

  1. Gene expression profiling of ERBB receptors and ligands in human transitional cell carcinoma of the bladder. (PMID: 16469638) Amsellem-Ouazana D. … Lidereau R. (J. Urol. 2006) 3 22 64
  2. Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity. (PMID: 15611079) Kochupurakkal B.S. … Yarden Y. (J. Biol. Chem. 2005) 3 4 64
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Autocrine epidermal growth factor receptor ligand production and cetuximab response in head and neck squamous cell carcinoma cell lines. (PMID: 22193422) Oshima G. … Ekblad L. (J. Cancer Res. Clin. Oncol. 2012) 3 64

Products for EPGN Gene

Sources for EPGN Gene

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