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Aliases for EPGN Gene

Aliases for EPGN Gene

  • Epithelial Mitogen 2 3 4
  • EPG 3 4
  • Epithelial Mitogen Homolog (Mouse) 2
  • Epithelial Mitogen Homolog 3
  • ALGV3072 3
  • PRO9904 3

External Ids for EPGN Gene

Previous GeneCards Identifiers for EPGN Gene

  • GC04P075540
  • GC04P075394
  • GC04P075174
  • GC04P070985

Summaries for EPGN Gene

Entrez Gene Summary for EPGN Gene

  • The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for EPGN Gene

EPGN (Epithelial Mitogen) is a Protein Coding gene. Diseases associated with EPGN include dicrocoeliasis and trichostrongylosis. GO annotations related to this gene include growth factor activity and epidermal growth factor receptor binding.

UniProtKB/Swiss-Prot for EPGN Gene

  • Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPGN Gene

Genomics for EPGN Gene

Regulatory Elements for EPGN Gene

Genomic Location for EPGN Gene

Chromosome:
4
Start:
74,308,270 bp from pter
End:
74,317,298 bp from pter
Size:
9,029 bases
Orientation:
Plus strand

Genomic View for EPGN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for EPGN Gene

Proteins for EPGN Gene

  • Protein details for EPGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW88-EPGN_HUMAN
    Recommended name:
    Epigen
    Protein Accession:
    Q6UW88
    Secondary Accessions:
    • A1BMM3
    • A1BMM4
    • A1BMM5
    • A1BMM6
    • A1BMM7
    • A1BMM8
    • A8K090

    Protein attributes for EPGN Gene

    Size:
    154 amino acids
    Molecular mass:
    17091 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EPGN Gene

neXtProt entry for EPGN Gene

Proteomics data for EPGN Gene at MOPED

Post-translational modifications for EPGN Gene

  • Glycosylation at Asn 37 and Asn 41
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for EPGN Gene

Domains & Families for EPGN Gene

Protein Domains for EPGN Gene

Suggested Antigen Peptide Sequences for EPGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UW88

UniProtKB/Swiss-Prot:

EPGN_HUMAN :
  • Contains 1 EGF-like domain.
Domain:
  • Contains 1 EGF-like domain.
genes like me logo Genes that share domains with EPGN: view

No data available for Gene Families for EPGN Gene

Function for EPGN Gene

Molecular function for EPGN Gene

UniProtKB/Swiss-Prot Function:
Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.

Gene Ontology (GO) - Molecular Function for EPGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005154 epidermal growth factor receptor binding IDA 15611079
GO:0005515 protein binding --
GO:0008083 growth factor activity IDA 15611079
genes like me logo Genes that share ontologies with EPGN: view

Phenotypes for EPGN Gene

genes like me logo Genes that share phenotypes with EPGN: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EPGN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EPGN Gene

Localization for EPGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPGN Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 2: Membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.
Isoform 4: Secreted.
Isoform 5: Secreted.
Isoform 6: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPGN Gene COMPARTMENTS Subcellular localization image for EPGN gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EPGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005622 intracellular IEA --
GO:0005887 integral component of plasma membrane IDA 15611079
genes like me logo Genes that share ontologies with EPGN: view

Pathways & Interactions for EPGN Gene

SuperPathways for EPGN Gene

No Data Available

Interacting Proteins for EPGN Gene

SIGNOR curated interactions for EPGN Gene

Activates:

Gene Ontology (GO) - Biological Process for EPGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000187 activation of MAPK activity ISS --
GO:0001525 angiogenesis IDA 15611079
GO:0007173 epidermal growth factor receptor signaling pathway IBA --
GO:0008284 positive regulation of cell proliferation IDA 15611079
genes like me logo Genes that share ontologies with EPGN: view

No data available for Pathways by source for EPGN Gene

Drugs & Compounds for EPGN Gene

No Compound Related Data Available

Transcripts for EPGN Gene

Unigene Clusters for EPGN Gene

Epithelial mitogen:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EPGN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPGN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: -
SP3: - -

Relevant External Links for EPGN Gene

GeneLoc Exon Structure for
EPGN
ECgene alternative splicing isoforms for
EPGN

Expression for EPGN Gene

mRNA expression in normal human tissues for EPGN Gene

mRNA differential expression in normal tissues according to GTEx for EPGN Gene

This gene is overexpressed in Esophagus - Mucosa (x27.7), Vagina (x5.5), and Minor Salivary Gland (x5.1).

SOURCE GeneReport for Unigene cluster for EPGN Gene Hs.401237

genes like me logo Genes that share expression patterns with EPGN: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for EPGN Gene

Orthologs for EPGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for EPGN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EPGN 35
  • 90.73 (n)
  • 88.08 (a)
EPGN 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPGN 35
  • 89.62 (n)
  • 87.42 (a)
EPGN 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Epgn 35
  • 81.63 (n)
  • 81.63 (a)
Epgn 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EPGN 35
  • 99.57 (n)
  • 100 (a)
EPGN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Epgn 35
  • 78.15 (n)
  • 76.82 (a)
oppossum
(Monodelphis domestica)
Mammalia EPGN 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EPGN 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves EPGN 35
  • 66.44 (n)
  • 62.16 (a)
EPGN 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPGN 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia epgn 35
  • 56.57 (n)
  • 46.21 (a)
Species with no ortholog for EPGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EPGN Gene

ENSEMBL:
Gene Tree for EPGN (if available)
TreeFam:
Gene Tree for EPGN (if available)

Paralogs for EPGN Gene

(3) SIMAP similar genes for EPGN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EPGN: view

No data available for Paralogs for EPGN Gene

Variants for EPGN Gene

Structural Variations from Database of Genomic Variants (DGV) for EPGN Gene

Variant ID Type Subtype PubMed ID
nsv525980 CNV Gain 19592680

Variation tolerance for EPGN Gene

Residual Variation Intolerance Score: 44.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPGN Gene

HapMap Linkage Disequilibrium report
EPGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for EPGN Gene

Disorders for EPGN Gene

MalaCards: The human disease database

(8) MalaCards diseases for EPGN Gene - From: DISEASES

Disorder Aliases PubMed IDs
dicrocoeliasis
  • disease due to dicrocoeliidae
trichostrongylosis
  • trichostrongyliasis
capillariasis
  • capillaria infection
trichostrongyloidiasis
necatoriasis
- elite association
Search EPGN in MalaCards View complete list of genes associated with diseases

Relevant External Links for EPGN

Genetic Association Database (GAD)
EPGN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EPGN
genes like me logo Genes that share disorders with EPGN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EPGN Gene

Publications for EPGN Gene

  1. Gene expression profiling of ERBB receptors and ligands in human transitional cell carcinoma of the bladder. (PMID: 16469638) Amsellem-Ouazana D. … Lidereau R. (J. Urol. 2006) 23 67
  2. Canonical WNT signaling pathway and human AREG. (PMID: 16685431) Katoh Y. … Katoh M. (Int. J. Mol. Med. 2006) 23 67
  3. Genetic variants associated with breast size also influence breast cancer risk. (PMID: 22747683) Eriksson N. … Tung J.Y. (BMC Med. Genet. 2012) 67
  4. EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling. (PMID: 22260327) Wilson K.J. … Riese D.J. (Growth Factors 2012) 67
  5. Autocrine epidermal growth factor receptor ligand production and cetuximab response in head and neck squamous cell carcinoma cell lines. (PMID: 22193422) Oshima G. … Ekblad L. (J. Cancer Res. Clin. Oncol. 2012) 67

Products for EPGN Gene

Sources for EPGN Gene

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