Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EPC2 Gene

Aliases for EPC2 Gene

  • Enhancer Of Polycomb Homolog 2 2 3 5
  • EPC-LIKE 3 4
  • Enhancer Of Polycomb Homolog 2 (Drosophila) 2

External Ids for EPC2 Gene

Previous GeneCards Identifiers for EPC2 Gene

  • GC02P149614
  • GC02P149236
  • GC02P149118
  • GC02P149402
  • GC02P141400

Summaries for EPC2 Gene

GeneCards Summary for EPC2 Gene

EPC2 (Enhancer Of Polycomb Homolog 2) is a Protein Coding gene. Diseases associated with EPC2 include Lymph Node Tuberculosis and Esophagitis, Eosinophilic, 1. An important paralog of this gene is EPC1.

UniProtKB/Swiss-Prot for EPC2 Gene

  • May play a role in transcription or DNA repair.

Additional gene information for EPC2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPC2 Gene

Genomics for EPC2 Gene

Regulatory Elements for EPC2 Gene

Enhancers for EPC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H148613 1.5 FANTOM5 Ensembl ENCODE 25.9 -29.6 -29558 2.7 PKNOX1 ATF1 FEZF1 FOS ATF7 JUNB MEF2D MAFF SMARCA4 GLIS1 EPC2 LOC101928553 GC02P148613 GC02M148622
GH02H148645 1.1 ENCODE 15.9 +0.9 896 3.1 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B EPC2 GC02M148646
GH02H149068 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10 +425.1 425149 2.1 MXI1 NFIB MAX SIN3A CEBPG BMI1 CTBP1 GATA3 FOS RCOR1 LYPD6B EPC2 KIF5C TXNP5 GC02M149098
GH02H148976 0.7 Ensembl 19.3 +331.7 331661 0.2 ZNF202 ZNF680 ZFP64 ZC3H11A ZNF140 ZNF266 REST ZBTB8A ZNF623 ZNF781 EPC2 MBD5 LOC101928553 LYPD6B
GH02H148552 1 Ensembl ENCODE dbSUPER 11.4 -91.2 -91240 1.2 IRF2 ID3 MNT ZNF83 EPC2 GC02M148556 GC02M148522
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EPC2 on UCSC Golden Path with GeneCards custom track

Promoters for EPC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for EPC2 Gene

Genomic Locations for EPC2 Gene
144,052 bases
Plus strand

Genomic View for EPC2 Gene

Genes around EPC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPC2 Gene

Proteins for EPC2 Gene

  • Protein details for EPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Enhancer of polycomb homolog 2
    Protein Accession:
    Secondary Accessions:
    • B3KWT7
    • D3DP89
    • Q7L9J1
    • Q96RR7
    • Q9NUT8
    • Q9NVR1
    • Q9UFM9

    Protein attributes for EPC2 Gene

    807 amino acids
    Molecular mass:
    91095 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH93818.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH93820.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK60500.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91688.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92032.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for EPC2 Gene

Post-translational modifications for EPC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EPC2 Gene

No data available for DME Specific Peptides for EPC2 Gene

Domains & Families for EPC2 Gene

Gene Families for EPC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EPC2 Gene

Suggested Antigen Peptide Sequences for EPC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the enhancer of polycomb family.
  • Belongs to the enhancer of polycomb family.
genes like me logo Genes that share domains with EPC2: view

Function for EPC2 Gene

Molecular function for EPC2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in transcription or DNA repair.

Phenotypes From GWAS Catalog for EPC2 Gene

Gene Ontology (GO) - Molecular Function for EPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004402 contributes_to histone acetyltransferase activity IBA --
genes like me logo Genes that share ontologies with EPC2: view
genes like me logo Genes that share phenotypes with EPC2: view

Animal Models for EPC2 Gene

MGI Knock Outs for EPC2:
  • Epc2 tm1b(EUCOMM)Wtsi
  • Epc2 tm1a(EUCOMM)Wtsi

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPC2 Gene

Localization for EPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EPC2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0032777 Piccolo NuA4 histone acetyltransferase complex IBA,IEA --
GO:0035267 NuA4 histone acetyltransferase complex IEA --
genes like me logo Genes that share ontologies with EPC2: view

Pathways & Interactions for EPC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA,IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with EPC2: view

No data available for Pathways by source and SIGNOR curated interactions for EPC2 Gene

Drugs & Compounds for EPC2 Gene

No Compound Related Data Available

Transcripts for EPC2 Gene

Unigene Clusters for EPC2 Gene

Enhancer of polycomb homolog 2 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPC2 Gene

No ASD Table

Relevant External Links for EPC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EPC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EPC2 Gene

Protein differential expression in normal tissues from HIPED for EPC2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (47.1), CD8 Tcells (9.7), and Retina (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EPC2 Gene

Protein tissue co-expression partners for EPC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of EPC2 Gene:


SOURCE GeneReport for Unigene cluster for EPC2 Gene:


Evidence on tissue expression from TISSUES for EPC2 Gene

  • Nervous system(4.4)
  • Kidney(4.2)
  • Liver(4.2)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with EPC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EPC2 Gene

Orthologs for EPC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EPC2 33 34
  • 99.8 (n)
(Canis familiaris)
Mammalia EPC2 33 34
  • 97.42 (n)
(Monodelphis domestica)
Mammalia EPC2 34
  • 97 (a)
(Bos Taurus)
Mammalia EPC2 33 34
  • 96.7 (n)
(Mus musculus)
Mammalia Epc2 33 16 34
  • 94.47 (n)
(Rattus norvegicus)
Mammalia Epc2 33
  • 94.38 (n)
(Ornithorhynchus anatinus)
Mammalia EPC2 34
  • 91 (a)
(Gallus gallus)
Aves EPC2 33 34
  • 88.06 (n)
(Anolis carolinensis)
Reptilia EPC2 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia epc2 33
  • 81.03 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19469 33
(Danio rerio)
Actinopterygii epc2 33 34
  • 64.21 (n)
zgc55784 33
fruit fly
(Drosophila melanogaster)
Insecta E(Pc) 34
  • 12 (a)
(Caenorhabditis elegans)
Secernentea epc-1 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
Species where no ortholog for EPC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EPC2 Gene

Gene Tree for EPC2 (if available)
Gene Tree for EPC2 (if available)

Paralogs for EPC2 Gene

Paralogs for EPC2 Gene

(3) SIMAP similar genes for EPC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EPC2: view

Variants for EPC2 Gene

Sequence variations from dbSNP and Humsavar for EPC2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000010253 -- 148,750,373(+) GATGT(A/G)GGCAT intron-variant
rs1000022907 -- 148,710,093(+) AATCT(A/C)CTCAT intron-variant
rs1000056117 -- 148,662,009(+) AAGGA(C/T)ATGAA intron-variant
rs1000080929 -- 148,700,934(+) TTTTT(A/T)ATTTC intron-variant
rs1000100366 -- 148,671,473(+) GTCAG(G/T)CATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPC2 Gene

Variant ID Type Subtype PubMed ID
nsv955262 CNV duplication 24416366
nsv508873 CNV insertion 20534489
esv3383687 CNV insertion 20981092
esv3378945 CNV insertion 20981092
esv2751831 CNV gain 17911159
esv2619674 CNV deletion 19546169
esv2496316 CNV deletion 19546169
esv1388120 CNV insertion 17803354

Variation tolerance for EPC2 Gene

Residual Variation Intolerance Score: 12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPC2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPC2 Gene

Disorders for EPC2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for EPC2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
lymph node tuberculosis
  • king's evil
esophagitis, eosinophilic, 1
  • eosinophilic esophagitis
mowat-wilson syndrome
  • hirschsprung disease mental retardation syndrome
peptic esophagitis
  • peptic reflux disease
esophageal disease
  • esophageal ulcer
- elite association - COSMIC cancer census association via MalaCards
Search EPC2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EPC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with EPC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EPC2 Gene

Publications for EPC2 Gene

  1. Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort. (PMID: 21123754) Kim S … Alzheimer's Disease Neuroimaging Initiative (Neurology 2011) 3 45 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D … Ferrucci L (PLoS genetics 2008) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for EPC2 Gene

Sources for EPC2 Gene

Loading form....