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EPB49 Gene

protein-coding GIFtS: 59

GC08P021967

erythrocyte membrane protein band 4.9 (dematin)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DMT ^¹, ², ³, ⁵
FLJ78462 ^²
FLJ98848 ^²
dematin ^²

Descriptions
Erythrocyte membrane protein band 4.9 ^², ³
erythrocyte membrane protein band 4.9 (dematin) ^²

External Ids
HGNC: 3382¹
Entrez Gene: 2039²
UniProtKB: Q08495³
Ensembl: ENSG00000158856⁷

Search outside databases for aliases for EPB49 gene

Previous GC identifers: GC08P021672 GC08P022265 GC08P021727 GC08P021937 GC08P021938

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EPB49:

Dematin, or EPB49, is an actin-bundling protein originally identified in the erythroid membrane

skeleton. Its actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein

kinase and is restored after dephosphorylation (Rana et al., 1993 [PubMed 8341682]).[supplied by

OMIM]

UniProtKB/Swiss-Prot: DEMA_HUMAN, Q08495

Function: Actin-bundling protein. May function in mitogen-activated protein kinase pathway

Gene Wiki entry for EPB49

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EPB49 gene

Entrez Gene cytogenetic band: 8p21.1 Ensembl cytogenetic band: 8p21.3 HGNC cytogenetic band: 8p21.1

EPB49 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P021967: (about GC identifiers)

Start:	21,971,322 bp from pter
End:	21,995,982 bp from pter
Size:	24,661 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_023666.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: DEMA_HUMAN, Q08495 (See protein sequence)

Recommended Name: Dematin

Size: 405 amino acids; 45514 Da

Subunit: Exists in solution as a trimer of two short isoforms and one long isoform linked by

disulfide bonds (Probable). Interacts with RASGRF2

Subcellular location: Cytoplasm

PDB structure from and Proteopedia :

1QZP (3D)

1ZV6 (3D)

Secondary accessions: A8K0T5 B3KP70 Q13215 Q9BRE3

Alternative splicing: 2 isoforms: Q08495-1 Q08495-2

Post-translational modifications:

Actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase¹

The N-terminus is blocked¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (6 alternative transcripts):

NP_001107607.1 NP_001107608.1 NP_001107609.1 NP_001107610.1 NP_001107611.1 NP_001969.2

ENSEMBL proteins:

ENSP00000265800 ENSP00000370864 ENSP00000370879 ENSP00000350977

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Dematin)
	Human Recombinant Proteins from Abnova (EPB49)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0015629	actin cytoskeleton	TAS	8341682

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Antibodies for EPB49:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for EPB49
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Dematin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EPB49)
	Novus Biologicals Antibodies for EPB49

Assays for EPB49:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q08495

ProtoNet protein and cluster: Q08495

1 Blocks protein family: IPB003128 Villin headpiece

UniProtKB/Swiss-Prot: DEMA_HUMAN, Q08495

Domain: Contains at least two actin-binding sites, one in the headpiece domain and one in the

amino-terminal portion

Domain: Consists of a large core fragment, the amino-terminal portion, and a small headpiece, the

C-terminal portion. The headpiece can bind but cannot bundle actin filaments

Similarity: Belongs to the villin/gelsolin family

Similarity: Contains 1 HP (headpiece) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EPB49)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 8): NM_001978

Applied Biosystems Silencer® siRNAs for EPB49

Sigma-Aldrich siRNA for EPB49

Sigma-Aldrich shRNA for EPB49

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EPB49
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_001114135
Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_001114135
untagged cDNA clones in CMV expression vector (see all 8): BC017445

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001114136

UniProtKB/Swiss-Prot: DEMA_HUMAN, Q08495

Function: Actin-bundling protein. May function in mitogen-activated protein kinase pathway

Genatlas biochemistry entry for EPB49:

erythrocyte surface protein 4.9,dematin,52kDa,actin binding protein,with homology with EPB42,villin

family,including two isoforms in the brain

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Epb4.9):

hematopoietic system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/18 Interacting proteins for EPB49 (ENSP00000370864³ Q08495²) via UniProtKB, MINT, and/or STRING (see all 18 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PROCR	Q9UNN8²	MINT-64074
SNRPD2	P62316²	MINT-64072
SPTB	ENSP00000334218³	STRING (score=.853)
TAT	ENSP00000348234³	STRING (score=.84)
PCNA	ENSP00000368438³	STRING (score=.8)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007010	cytoskeleton organization	TAS	7615546
GO:0051016	barbed-end actin filament capping	IEA	--
GO:0051017	actin filament bundle formation	TAS	7615546

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EPB49

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EPB49)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 8): NM_001978

Sigma-Aldrich siRNA for EPB49

Sigma-Aldrich shRNA for EPB49

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001114135 NM_001114136 NM_001114137 NM_001114138 NM_001114139 NM_001978

REFSEQ mRNAs for EPB49 gene (6 alternative transcripts):

NM_001114135.2 NM_001114136.1 NM_001114137.1 NM_001114138.1 NM_001114139.1 NM_001978.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001114135 NM_001114136 NM_001114137 NM_001114138 NM_001114139 NM_001978

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_001114135
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_001114135
                                 untagged cDNA clones in CMV expression vector (see all 8): BC017445

Additional cDNA sequence:

AB209718.1 AK055842.1 AK091581.1 AK289650.1 AK295452.1 BC006318.2 BC017445.1 BC052805.1

BT007396.1 L19713.1 U28389.1

24 DOTS entries:

DT.100817765 DT.92422954 DT.95187740 DT.452935 DT.95187741 DT.95187747 DT.100817758 DT.121488742

DT.95187737 DT.121488731 DT.95187746 DT.100817767 DT.100682649 DT.100817764 DT.100817766 DT.100836076

DT.121488754 DT.95226353 DT.91952423 DT.100817756 DT.100817763 DT.121488707 DT.121488717 DT.121488725

24/168 AceView cDNA sequences (see all 168 ):

CB155183 F03346 CD674915 AW339606 F30467 BG055677 BI823974 AW473094

CK820030 AL138164 BX644547 BM141877 H26969 T34776 H65304 BX406256

R40779 AW473097 BF510971 F08518 AA383081 F04623 BX406966 T36075

highest scoring ESTs for EPB49:

U28389 AA017251 AA338567 AA383081 AA666415 AI022986 AI866233 AK055842 AK091581 AW148980

Unigene Cluster for EPB49:

Erythrocyte membrane protein band 4.9 (dematin)

Hs.106124 [show with all ESTs]

Unigene Representative Sequence: NM_001978

GeneLoc Exon Structure

5/20 Alternative Splicing Database (ASD) splice patterns (SP) for EPB49 (see all 20 )

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	·	6d	^	7	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	·	10c	^	11	^
SP1:																					-		-				-		-		-																-		-
SP2:					-		-		-		-		-		-		-		-		-		-		-		-		-		-																-		-
SP3:											-		-		-		-		-		-		-		-		-		-		-						-										-		-
SP4:																	-		-		-		-		-		-		-		-						-										-		-
SP5:

ExUns:	12a	·	12b	^	13a	·	13b	·	13c	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b
SP1:
SP2:
SP3:
SP4:
SP5:																					-

About this scheme

ECgene alternative splicing isoforms for EPB49

4 Ensembl transcripts including schematic representations:

ENST00000265800 ENST00000381455 ENST00000381470 ENST00000358242

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EPB49 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EPB49

¹ / ² / ³

4 probe-sets matching EPB49 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37192_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.91	U28389	1.00	1.00	1.00	1
75162_r_at²^{, 3}	U95-D	2	0.44	0.88	0.93	1.10	AI673236	0.40	1.00	0.76	1
204505_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001978	0.60	1.00	0.82	1
204505_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.106124
Expression variation in blood from EXPOLDB for EPB49
UniProtKB/Swiss-Prot: DEMA_HUMAN, Q08495
Tissue specificity: Heart, brain, lung, skeletal muscle, and kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EPB49 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EPB49¹	--	erythrocyte membrane protein band 4.9 (dematin)	90.89(n) 96.49(a)	486132 XM_543258.2 XP_543258.2
chimpanzee (Pan troglodytes)	EPB49¹	--	erythrocyte membrane protein band 4.9 (dematin)	99.51(n) 99.51(a)	741796 XM_001152704.1 XP_001152704.1
rat (Rattus norvegicus)	Epb4.9¹	--	erythrocyte protein band 4.9	88.2(n) 94.32(a)	361069 XM_341352.3 XP_341353.3
mouse (Mus musculus)	Epb4.9^{1, 5}	14 (38.00 cM)⁵	erythrocyte protein band 4.9^{1, 5}	89.12(n)¹ 95.56(a)¹	13829¹ NM_013514.3¹ NP_038542.1¹ AF079846⁵ AF155547⁵ (see all 19)
zebrafish (Danio rerio)	wufj78f01²	--	Transcribed sequence with weak similarity to protein more	75.57(n)	CD598541.1

About this table Species with no ortholog for EPB49

ENSEMBL Gene Tree for EPB49

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EPB49 gene

ABLIM3² ABLIM2² ABLIM1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/212 NCBI SNPs in EPB49 are shown (see all 212 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 49)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6557782^1,2	A,C,F,H	21995381(+)	`GCAGCT/CTCCTG`	6	--	ut3¹ ese³		4		EU EA WA	412
	rs12541126^1,2	C,F,H	21967177(+)	`AGGAAT/CCCTGG`	1	--	ut5¹ ese³		8		EU EA WA	838
	rs1063443^1,2	C,F,H	21995876(+)	`CAGGTC/TTGGGT`	6	--	ut3¹		5		MN EU EA WA	602
--	rs9657287^1,2	A,C	21980243(+)	`CGCAGC/TGCCCA`	4	--	ut5¹ ese³		0	--	--	--	--
	rs11994442^1,2	F,H	21972678(+)	`aagcaG/Aaaaga`	2	--	ut5¹		4		EU EA WA	420
	rs7836493^1,2	A,C	21996377(+)	`GGTGCC/TCATGG`	1	--	ng3¹		0	--	--	--	--
--	rs7846066^1,2	C,F	21996398(+)	`AGGCCA/GAACAC`	1	--	ng3¹		3		NA EA	272
	rs1872224^1,2	A,C	21996067(+)	`AGGGTG/TCCAAT`	1	--	ng3¹		0	--	--	--	--
	rs3739433^1,2	H	21972582(+)	`ACTGCG/AGGGGT`	1	--	ng5¹		4		EU EA WA	418
	rs3808651^1,2	H	21971609(-)	`CAGGAC/TGCATG`	1	--	ng5¹		5		EA EU WA	1914

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HapMap Linkage Disequilibrium images for EPB49 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 125305

3 Novoseek disease relationships for EPB49 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
spherocytosis hereditary	73.71	1	7615546 (1)
anemia hemolytic	43.79	1	7615546 (1)
prostate cancer	7.70	2	10565303 (2)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/29 PubMed articles for EPB49 gene (see all 29 ):

Cloning of human erythroid dematin reveals another member of the villin family. (PubMed id 8341682)^{1, 2, 3, 4} Rana A.P.... Chishti A.H. (1993)
Isoform cloning, actin binding, and chromosomal localization of human erythroid dematin, a member of the villin superfamily. (PubMed id 7615546)^{1, 3, 4} Azim A.C.... Chishti A.H. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Headpiece domain of dematin is required for the stability of the erythrocyte membrane. (PubMed id 12011427)^{2, 3} Khanna R....Chishti A.H. (2002)
Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways. (PubMed id 11856323)^{1, 4} Lutchman M.... Chishti A.H. (2002)
The NMR structure of dematin headpiece reveals a dynamic loop that is conformationally altered upon phosphorylation at a distal site. (PubMed id 14660664)^{1, 3} Frank B.S....McKnight C.J. (2004)
Human erythrocyte dematin and protein 4.2 (pallidin) are ATP binding proteins. (PubMed id 8608138)^{1, 3} Azim A.C....Chishti A.H. (1996)
Phosphorylation-induced changes in backbone dynamics of the dematin headpiece C-terminal domain. (PubMed id 19030997)^{1, 3} Vugmeyster L. and McKnight C.J. (2009)
Identification of the PXW sequence as a structural gatekeeper of the headpiece C-terminal subdomain fold. (PubMed id 16697408)^{1, 3} Vermeulen W....Ampe C. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2039	HGNC: 3382	AceView: EPB49	Ensembl:ENSG00000158856	euGenes: HUgn2039
ECgene: EPB49	H-InvDB: EPB49

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for EPB49	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for EPB49
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for EPB49:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EPB49-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EPB49		Antibodies for EPB49
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for EPB49		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (EPB49)
	Antibodies (EPB49)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Dematin)
	Antibodies (Dematin)

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Search Tocris compounds for EPB49

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for EPB49

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EPB49 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for EPB49

Summaries
for EPB49

Genomic Location
for EPB49

Proteins
for EPB49

Protein Domains/
Families
for EPB49

Gene Function
for EPB49

Pathways & Interactions
for EPB49

Drugs & Compounds
for EPB49

Transcripts
for EPB49

Expression
for EPB49

Orthologs
for EPB49

Paralogs
for EPB49

SNPs/Variants
for EPB49

Disorders & Mutations
for EPB49

Medical News
for EPB49

Publications
for EPB49

Search for EPB49

Genome Databases showing EPB49

Other Databases showing EPB49

Specialized Databases showing EPB49

Licensable Technologies
for EPB49

Services
for EPB49

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EPB49 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor EPB49

Summariesfor EPB49

Genomic Locationfor EPB49

Proteinsfor EPB49

Protein Domains/Familiesfor EPB49

Gene Functionfor EPB49

Pathways & Interactionsfor EPB49

Drugs & Compoundsfor EPB49

Transcriptsfor EPB49

Expression for EPB49

Orthologsfor EPB49

Paralogsfor EPB49

SNPs/Variantsfor EPB49

Disorders & Mutationsfor EPB49

Medical Newsfor EPB49

Publicationsfor EPB49

Search for EPB49

Genome Databases showing EPB49

Other Databases showing EPB49

Specialized Databases showing EPB49

Licensable Technologiesfor EPB49

Servicesfor EPB49

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EPB49

Summaries
for EPB49

Genomic Location
for EPB49

Proteins
for EPB49

Protein Domains/
Families
for EPB49

Gene Function
for EPB49

Pathways & Interactions
for EPB49

Drugs & Compounds
for EPB49

Transcripts
for EPB49

Expression
for EPB49

Orthologs
for EPB49

Paralogs
for EPB49

SNPs/Variants
for EPB49

Disorders & Mutations
for EPB49

Medical News
for EPB49

Publications
for EPB49

Licensable Technologies
for EPB49

Services
for EPB49