Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EPB41L5 Gene

Aliases for EPB41L5 Gene

  • Erythrocyte Membrane Protein Band 4.1 Like 5 2 3
  • KIAA1548 4 6
  • Band 4.1-Like Protein 5 3
  • BE37 3
  • YMO1 3

External Ids for EPB41L5 Gene

Previous GeneCards Identifiers for EPB41L5 Gene

  • GC02P118691
  • GC02P120677
  • GC02P120865
  • GC02P120486
  • GC02P113095
  • GC02P120770

Summaries for EPB41L5 Gene

GeneCards Summary for EPB41L5 Gene

EPB41L5 (Erythrocyte Membrane Protein Band 4.1 Like 5) is a Protein Coding gene. Diseases associated with EPB41L5 include intussusception. GO annotations related to this gene include protein domain specific binding and cytoskeletal protein binding. An important paralog of this gene is FRMD3.

UniProtKB/Swiss-Prot for EPB41L5 Gene

  • May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPB41L5 Gene

Genomics for EPB41L5 Gene

Regulatory Elements for EPB41L5 Gene

Genomic Location for EPB41L5 Gene

Start:
120,013,005 bp from pter
End:
120,179,121 bp from pter
Size:
166,117 bases
Orientation:
Plus strand

Genomic View for EPB41L5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPB41L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPB41L5 Gene

Proteins for EPB41L5 Gene

  • Protein details for EPB41L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCM4-E41L5_HUMAN
    Recommended name:
    Band 4.1-like protein 5
    Protein Accession:
    Q9HCM4
    Secondary Accessions:
    • Q7Z5S1
    • Q8IZ12
    • Q9H975

    Protein attributes for EPB41L5 Gene

    Size:
    733 amino acids
    Molecular mass:
    81856 Da
    Quaternary structure:
    • Interacts with MPP5, CRB2 and CRB3.

    Alternative splice isoforms for EPB41L5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPB41L5 Gene

Proteomics data for EPB41L5 Gene at MOPED

Post-translational modifications for EPB41L5 Gene

  • Ubiquitination at Lys40, Lys350, Lys508, and Lys510
  • Modification sites at PhosphoSitePlus

Other Protein References for EPB41L5 Gene

Antibody Products

No data available for DME Specific Peptides for EPB41L5 Gene

Domains for EPB41L5 Gene

Suggested Antigen Peptide Sequences for EPB41L5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCM4

UniProtKB/Swiss-Prot:

E41L5_HUMAN :
  • Q9HCM4
Domain:
  • The FERM domain binds to CRB1
  • Contains 1 FERM domain.
genes like me logo Genes that share domains with EPB41L5: view

No data available for Gene Families for EPB41L5 Gene

Function for EPB41L5 Gene

Molecular function for EPB41L5 Gene

UniProtKB/Swiss-Prot Function:
May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells.

Gene Ontology (GO) - Molecular Function for EPB41L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008092 cytoskeletal protein binding IEA --
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with EPB41L5: view
genes like me logo Genes that share phenotypes with EPB41L5: view

Animal Models for EPB41L5 Gene

MGI Knock Outs for EPB41L5:

Animal Model Products

CRISPR Products

miRNA for EPB41L5 Gene

miRTarBase miRNAs that target EPB41L5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EPB41L5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for EPB41L5 Gene

Localization for EPB41L5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPB41L5 Gene

Cytoplasm. Cell junction, adherens junction. Note=Associated with the plasma membrane. Colocalizes with CTNNB1, an adherens junction marker (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPB41L5 Gene COMPARTMENTS Subcellular localization image for EPB41L5 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 3
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EPB41L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA --
GO:0005925 focal adhesion IEA --
genes like me logo Genes that share ontologies with EPB41L5: view

Pathways for EPB41L5 Gene

SuperPathways for EPB41L5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EPB41L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000904 cell morphogenesis involved in differentiation --
GO:0001701 in utero embryonic development IEA --
GO:0001756 somitogenesis --
GO:0001837 epithelial to mesenchymal transition IEA --
GO:0001839 neural plate morphogenesis IEA --
genes like me logo Genes that share ontologies with EPB41L5: view

No data available for Pathways by source for EPB41L5 Gene

Transcripts for EPB41L5 Gene

Unigene Clusters for EPB41L5 Gene

Erythrocyte membrane protein band 4.1 like 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EPB41L5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPB41L5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^
SP1: - - -
SP2: - - -
SP3: - -
SP4:
SP5: -

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1:
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for EPB41L5 Gene

GeneLoc Exon Structure for
EPB41L5
ECgene alternative splicing isoforms for
EPB41L5

Expression for EPB41L5 Gene

mRNA expression in normal human tissues for EPB41L5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for EPB41L5 Gene

This gene is overexpressed in Lung (19.0), Testis (18.0), and Retina (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EPB41L5 Gene

SOURCE GeneReport for Unigene cluster for EPB41L5 Gene Hs.369232

genes like me logo Genes that share expressions with EPB41L5: view

Expression partners for EPB41L5 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EPB41L5 Gene

Orthologs for EPB41L5 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPB41L5 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Epb4.1l5 35
  • 84.72 (n)
  • 84.13 (a)
Epb4.1l5 16
Epb4.1l5 36
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EPB41L5 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPB41L5 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EPB41L5 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EPB41L5 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EPB41L5 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves EPB41L5 35
  • 69.95 (n)
  • 74.34 (a)
EPB41L5 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPB41L5 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia epb4.1l5-prov 35
zebrafish
(Danio rerio)
Actinopterygii epb41l5 35
  • 63.95 (n)
  • 65.54 (a)
epb41l5 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta yrt 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea frm-2 36
  • 39 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1768 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToMany
Species with no ortholog for EPB41L5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for EPB41L5 Gene

ENSEMBL:
Gene Tree for EPB41L5 (if available)
TreeFam:
Gene Tree for EPB41L5 (if available)

Paralogs for EPB41L5 Gene

Selected SIMAP similar genes for EPB41L5 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for EPB41L5 Gene

genes like me logo Genes that share paralogs with EPB41L5: view

Variants for EPB41L5 Gene

Sequence variations from dbSNP and Humsavar for EPB41L5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs12603 -- 120,104,877(+) GAATG(G/T)TTAGT intron-variant, utr-variant-3-prime
rs938832 -- 120,062,675(-) AATTA(C/T)TGAAT intron-variant
rs938833 -- 120,131,131(+) GTACC(A/G)ATATA intron-variant
rs938834 -- 120,163,256(+) tcccT(C/T)TGCCC intron-variant
rs938835 -- 120,163,272(+) CCCCC(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPB41L5 Gene

Variant ID Type Subtype PubMed ID
nsv874963 CNV Gain 21882294
nsv834345 CNV Gain 17160897
nsv834346 CNV Gain 17160897
nsv524770 CNV Loss 19592680

Relevant External Links for EPB41L5 Gene

HapMap Linkage Disequilibrium report
EPB41L5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPB41L5 Gene

Disorders for EPB41L5 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for EPB41L5 Gene in MalaCards »

(1) Diseases for EPB41L5 Gene including...

(1) University of Copenhagen DISEASES for EPB41L5 Gene

genes like me logo Genes that share disorders with EPB41L5: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for EPB41L5 Gene

Publications for EPB41L5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5 polarity complex. (PMID: 17920587) Gosens I. … Roepman R. (Exp. Cell Res. 2007) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1. (PMID: 18729074) Brown K.A. … Moses H.L. (J. Cell. Biochem. 2008) 3

Products for EPB41L5 Gene

Sources for EPB41L5 Gene

Back to Top

Content