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Aliases for EPB41L4B Gene

Aliases for EPB41L4B Gene

  • Erythrocyte Membrane Protein Band 4.1 Like 4B 2 3
  • EHM2 3 4 6
  • FERM-Containing Protein CG1 3 4
  • Band 4.1-Like Protein 4B 3
  • Protein EHM2 4
  • CG1 3

External Ids for EPB41L4B Gene

Previous GeneCards Identifiers for EPB41L4B Gene

  • GC09M103666
  • GC09M105391
  • GC09M107314
  • GC09M107286
  • GC09M109013
  • GC09M110974
  • GC09M111934
  • GC09M081534

Summaries for EPB41L4B Gene

GeneCards Summary for EPB41L4B Gene

EPB41L4B (Erythrocyte Membrane Protein Band 4.1 Like 4B) is a Protein Coding gene. GO annotations related to this gene include structural constituent of cytoskeleton and cytoskeletal protein binding. An important paralog of this gene is FRMD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPB41L4B Gene

Genomics for EPB41L4B Gene

Regulatory Elements for EPB41L4B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EPB41L4B Gene

Start:
109,171,974 bp from pter
End:
109,320,964 bp from pter
Size:
148,991 bases
Orientation:
Minus strand

Genomic View for EPB41L4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPB41L4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPB41L4B Gene

Proteins for EPB41L4B Gene

  • Protein details for EPB41L4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H329-E41LB_HUMAN
    Recommended name:
    Band 4.1-like protein 4B
    Protein Accession:
    Q9H329
    Secondary Accessions:
    • Q5T4G5
    • Q5T4G6
    • Q9H328
    • Q9P2V3

    Protein attributes for EPB41L4B Gene

    Size:
    900 amino acids
    Molecular mass:
    99712 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG43366.1; Type=Frameshift; Positions=19, 35, 870; Evidence={ECO:0000305}; Sequence=AAG43368.1; Type=Frameshift; Positions=19, 35; Evidence={ECO:0000305};

    Alternative splice isoforms for EPB41L4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPB41L4B Gene

Proteomics data for EPB41L4B Gene at MOPED

Post-translational modifications for EPB41L4B Gene

  • Ubiquitination at Lys265
  • Modification sites at PhosphoSitePlus

Other Protein References for EPB41L4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EPB41L4B Gene

Domains for EPB41L4B Gene

Suggested Antigen Peptide Sequences for EPB41L4B Gene

Graphical View of Domain Structure for InterPro Entry

Q9H329

UniProtKB/Swiss-Prot:

E41LB_HUMAN :
  • Q9H329
Domain:
  • Contains 1 FERM domain.
genes like me logo Genes that share domains with EPB41L4B: view

No data available for Gene Families for EPB41L4B Gene

Function for EPB41L4B Gene

Gene Ontology (GO) - Molecular Function for EPB41L4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton TAS 10783258
GO:0005515 protein binding --
GO:0008092 cytoskeletal protein binding IEA --
genes like me logo Genes that share ontologies with EPB41L4B: view

Phenotypes for EPB41L4B Gene

GenomeRNAi human phenotypes for EPB41L4B:
genes like me logo Genes that share phenotypes with EPB41L4B: view

Animal Model Products

CRISPR Products

miRNA for EPB41L4B Gene

miRTarBase miRNAs that target EPB41L4B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EPB41L4B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EPB41L4B Gene

Localization for EPB41L4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPB41L4B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPB41L4B Gene COMPARTMENTS Subcellular localization image for EPB41L4B gene
Compartment Confidence
cytoskeleton 4
cytosol 3
mitochondrion 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for EPB41L4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0019898 extrinsic component of membrane IEA --
GO:0045177 apical part of cell IDA 22006950
genes like me logo Genes that share ontologies with EPB41L4B: view

Pathways for EPB41L4B Gene

SuperPathways for EPB41L4B Gene

No Data Available

Interacting Proteins for EPB41L4B Gene

Gene Ontology (GO) - Biological Process for EPB41L4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031032 actomyosin structure organization IDA 22006950
genes like me logo Genes that share ontologies with EPB41L4B: view

No data available for Pathways by source for EPB41L4B Gene

Transcripts for EPB41L4B Gene

Unigene Clusters for EPB41L4B Gene

Erythrocyte membrane protein band 4.1 like 4B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EPB41L4B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for EPB41L4B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPB41L4B Gene

No ASD Table

Relevant External Links for EPB41L4B Gene

GeneLoc Exon Structure for
EPB41L4B
ECgene alternative splicing isoforms for
EPB41L4B

Expression for EPB41L4B Gene

mRNA expression in normal human tissues for EPB41L4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPB41L4B Gene

This gene is overexpressed in Pancreas (11.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EPB41L4B Gene

SOURCE GeneReport for Unigene cluster for EPB41L4B Gene Hs.591901

genes like me logo Genes that share expressions with EPB41L4B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for EPB41L4B Gene

Orthologs for EPB41L4B Gene

This gene was present in the common ancestor of animals.

Orthologs for EPB41L4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPB41L4B 35
  • 99.56 (n)
  • 99.48 (a)
EPB41L4B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EPB41L4B 35
  • 91.19 (n)
  • 92.89 (a)
EPB41L4B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPB41L4B 35
  • 90.64 (n)
  • 92.35 (a)
EPB41L4B 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Epb4.1l4b 35
  • 90.71 (n)
  • 97.66 (a)
Epb4.1l4b 16
Epb4.1l4b 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EPB41L4B 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EPB41L4B 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Epb41l4b 35
  • 90.99 (n)
  • 97.66 (a)
chicken
(Gallus gallus)
Aves EPB41L4B 35
  • 74.66 (n)
  • 75.89 (a)
EPB41L4B 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPB41L4B 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488561 35
  • 72.04 (n)
  • 77.2 (a)
Str.7184 35
zebrafish
(Danio rerio)
Actinopterygii epb41l4b 36
  • 62 (a)
OneToOne
LOC100332627 35
  • 60.61 (n)
  • 59.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta yrt 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea frm-2 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for EPB41L4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EPB41L4B Gene

ENSEMBL:
Gene Tree for EPB41L4B (if available)
TreeFam:
Gene Tree for EPB41L4B (if available)

Paralogs for EPB41L4B Gene

Selected SIMAP similar genes for EPB41L4B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for EPB41L4B Gene

genes like me logo Genes that share paralogs with EPB41L4B: view

Variants for EPB41L4B Gene

Sequence variations from dbSNP and Humsavar for EPB41L4B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs729862 -- 109,258,836(-) TCCCG(A/C)AGTTG intron-variant
rs745388 -- 109,258,388(+) CATTA(C/T)AAAGC intron-variant
rs746417 -- 109,259,708(-) GGCCA(C/T)TCATC intron-variant
rs746418 -- 109,259,464(-) CTGAT(C/G)TGTGC intron-variant
rs750721 -- 109,259,263(+) ACTGA(G/T)GTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPB41L4B Gene

Variant ID Type Subtype PubMed ID
esv268070 CNV Insertion 20981092
esv2738910 CNV Deletion 23290073
nsv831685 CNV Gain 17160897
nsv893706 CNV Gain 21882294
nsv825033 CNV Gain 20364138
esv29273 CNV Loss 19812545

Relevant External Links for EPB41L4B Gene

HapMap Linkage Disequilibrium report
EPB41L4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPB41L4B Gene

Disorders for EPB41L4B Gene

Relevant External Links for EPB41L4B

Genetic Association Database (GAD)
EPB41L4B
Human Genome Epidemiology (HuGE) Navigator
EPB41L4B
genes like me logo Genes that share disorders with EPB41L4B: view

No data available for UniProtKB/Swiss-Prot for EPB41L4B Gene

Publications for EPB41L4B Gene

  1. Molecular cloning of a novel NF2/ERM/4.1 superfamily gene, Ehm2, that is expressed in high-metastatic K1735 murine melanoma cells. (PMID: 10783258) Shimizu K. … Yokota J. (Genomics 2000) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Cloning, mapping, and expression of a novel brain-specific transcript in the familial dysautonomia candidate region on chromosome 9q31. (PMID: 10603000) Chadwick B.P. … Slaugenhaupt S.A. (Mamm. Genome 2000) 3 4
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for EPB41L4B Gene

Sources for EPB41L4B Gene

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