Aliases for EPB41L3 Gene
Aliases for EPB41L3 Gene
External Ids for EPB41L3 Gene
- HGNC: 3380
- Entrez Gene: 23136
- Ensembl: ENSG00000082397
- OMIM: 605331
- UniProtKB: Q9Y2J2
Previous GeneCards Identifiers for EPB41L3 Gene
- GC18P005437
- GC18M005456
Summaries for EPB41L3 Gene
GeneCards Summary for EPB41L3 Gene
EPB41L3 (Erythrocyte Membrane Protein Band 4.1 Like 3) is a Protein Coding gene. Diseases associated with EPB41L3 include Benign Meningioma and Bejel. Among its related pathways are Transmission across Chemical Synapses and Protein-protein interactions at synapses. Gene Ontology (GO) annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is EPB41L2.
UniProtKB/Swiss-Prot for EPB41L3 Gene
-
Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.
Additional gene information for EPB41L3 Gene
- Monarch Initiative
- Search for EPB41L3 at DataMed
- Search for EPB41L3 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPB41L3 Gene
Genomics for EPB41L3 Gene
GeneHancer (GH) Regulatory Elements for EPB41L3 Gene
Promoters and enhancers for EPB41L3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around EPB41L3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for EPB41L3 Gene
Genomic Locations for EPB41L3 Gene
- chr18:5,392,381-5,630,700
- (GRCh38/hg38)
- Size:
- 238,320 bases
- Orientation:
- Minus strand
- chr18:5,392,383-5,630,699
- (GRCh37/hg19)
Genomic View for EPB41L3 Gene
Genes around EPB41L3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18p11.31 by Ensembl
- 18p11.31 by Entrez Gene
- 18p11.31 by HGNC
EPB41L3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EPB41L3 Gene
Proteins for EPB41L3 Gene
-
Protein details for EPB41L3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y2J2-E41L3_HUMAN
- Recommended name:
- Band 4.1-like protein 3
- Protein Accession:
- Q9Y2J2
- B7Z4I5
- F5GX05
- O95713
- Q9BRP5
Protein attributes for EPB41L3 Gene
- Size:
- 1087 amino acids
- Molecular mass:
- 120678 Da
- Quaternary structure:
-
- Interacts (via FERM domain) with CADM1. Interacts with PRMT3, PRMT5 and PRMT6.
- SequenceCaution:
-
- Sequence=AAC79806.1; Type=Frameshift; Positions=29, 59; Evidence={ECO:0000305}; Sequence=BAA76831.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for EPB41L3 Gene
Post-translational modifications for EPB41L3 Gene
- Ubiquitination at posLast=7575, posLast=162162, Lys336, and posLast=397397
Other Protein References for EPB41L3 Gene
- ENSEMBL proteins:
-
- ENSP00000343158
- ENSP00000382981
- ENSP00000441174
- ENSP00000442091
- ENSP00000461937
- ENSP00000462338
- ENSP00000462692
- ENSP00000462783
- ENSP00000463122
- ENSP00000463289
- ENSP00000463707
- ENSP00000464020
- ENSP00000464148
- ENSP00000464336
- ENSP00000464533
- ENSP00000464570
- ENSP00000487780
- ENSP00000487786
- ENSP00000487915
- ENSP00000488037
- ENSP00000488095
- ENSP00000488626
- ENSP00000488647
- ENSP00000489405
- ENSP00000489681
- ENSP00000341138
- REFSEQ proteins:
-
- NP_001268462.1
- NP_001268463.1
- NP_001268464.1
- NP_001317486.1
- NP_036439.2
- XP_011523925.1
- XP_011523928.1
- XP_011523930.1
- XP_011523934.1
- XP_011523936.1
- XP_011523939.1
- XP_016881107.1
- XP_016881108.1
- XP_016881109.1
- XP_016881110.1
- XP_016881111.1
- XP_016881112.1
- XP_016881113.1
- XP_016881114.1
- XP_016881115.1
- XP_016881116.1
- XP_016881117.1
- XP_016881118.1
- XP_016881119.1
- XP_016881120.1
- XP_016881121.1
- XP_016881122.1
- XP_016881123.1
- XP_016881124.1
- XP_016881125.1
- XP_016881126.1
- XP_016881127.1
- XP_016881128.1
- XP_016881129.1
- XP_016881130.1
- XP_016881131.1
- XP_016881132.1
- XP_016881133.1
- XP_016881134.1
- XP_016881135.1
- XP_016881136.1
- XP_016881137.1
- XP_016881138.1
- XP_016881139.1
- XP_016881140.1
- XP_016881141.1
- XP_016881142.1
- XP_016881143.1
- XP_016881144.1
- XP_016881145.1
- XP_016881146.1
- XP_016881147.1
- XP_016881148.1
- XP_016881149.1
Antibody Products
- Novus Biologicals Antibodies for EPB41L3
-
Abcam antibodies for EPB41L3
- Invitrogen Antibodies for EPB41L3
- GeneTex EPB41L3 antibody for EPB41L3
-
Santa Cruz Biotechnology (SCBT) Antibodies for EPB41L3
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for EPB41L3
- Origene Custom Protein Services for EPB41L3
- Search GeneTex for Proteins for EPB41L3
-
Abcam proteins for EPB41L3
Assay Products
- antibodies-online: Search results for 1 available EPB41L3 Elisa Kits ranked by validation data
- Compare Top EPB41L3 Elisa Kits
-
Recommended
No data available for DME Specific Peptides for EPB41L3 Gene
Domains & Families for EPB41L3 Gene
Gene Families for EPB41L3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for EPB41L3 Gene
Suggested Antigen Peptide Sequences for EPB41L3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for EPB41L3 Gene
Function for EPB41L3 Gene
Molecular function for EPB41L3 Gene
- GENATLAS Biochemistry:
- erythrocyte surface protein 4.1-like 3,expressed in the brain
- UniProtKB/Swiss-Prot Function:
- Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.
Phenotypes From GWAS Catalog for EPB41L3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
| GO:0005198 | structural molecule activity | IEA | -- |
| GO:0005200 | structural constituent of cytoskeleton | TAS | 21966409 |
| GO:0005515 | protein binding | IPI | 12234973 |
| GO:0008092 | cytoskeletal protein binding | IEA | -- |
Phenotypes for EPB41L3 Gene
- MGI mutant phenotypes for EPB41L3:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for EPB41L3:
Animal Models for EPB41L3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EPB41L3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for EPB41L3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EPB41L3 gene
- Search ViGene Biosciences for EPB41L3
CRISPR Products
-
OriGene CRISPR knockouts for EPB41L3
- genomics-online: gRNA clones - Search results for available EPB41L3 gene related products
- Applied Biological Materials CRISPR for EPB41L3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPB41L3
- GenScript: Design CRISPR guide RNA sequences for EPB41L3
miRNA for EPB41L3 Gene
- miRTarBase miRNAs that target EPB41L3
-
- hsa-mir-223-3p (MIRT006374)
- hsa-mir-877-3p (MIRT037171)
- hsa-mir-92a-3p (MIRT049330)
- hsa-let-7b-5p (MIRT051992)
- hsa-mir-1305 (MIRT551184)
- hsa-mir-498 (MIRT551185)
- hsa-mir-4465 (MIRT551186)
- hsa-mir-26b-5p (MIRT551187)
- hsa-mir-26a-5p (MIRT551188)
- hsa-mir-1297 (MIRT551189)
- hsa-mir-627-3p (MIRT551190)
- hsa-mir-4275 (MIRT551191)
- hsa-mir-5697 (MIRT551192)
- hsa-mir-551b-5p (MIRT551193)
- hsa-mir-548c-3p (MIRT551194)
- hsa-mir-4684-5p (MIRT637420)
- hsa-mir-3675-3p (MIRT637421)
- hsa-mir-4524b-3p (MIRT637422)
- hsa-mir-7161-5p (MIRT637423)
- hsa-mir-548u (MIRT637424)
miRNA Products
- Search ViGene Biosciences for EPB41L3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for EPB41L3
- Browse OriGene Inhibitory RNA Products For EPB41L3
- genomics-online: shRNA clones - Search results for available EPB41L3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for EPB41L3 gene
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for EPB41L3 in any vector
- XM_011525624.1
- XM_011525608.1
- NM_001281535.1
- XM_011525611.1
- XM_011525627.1
- XM_011525614.1
- XM_011525630.1
- XM_011525617.1
- XM_011525633.1
- XM_011525620.1
- XM_011525636.1
- XM_011525623.1
- XM_011525607.1
- NM_001281534.1
- XM_011525626.1
- XM_011525610.1
- XM_011525613.1
- XM_011525629.1
- NM_012307.3
- XM_011525616.1
- XM_011525632.1
- XM_011525619.1
- XM_011525635.1
- XM_011525622.1
- XM_011525606.1
- NM_001281533.1
- XM_011525625.1
- XM_011525609.1
- XM_011525612.1
- XM_011525628.1
- XM_011525615.1
- XM_011525631.1
- XM_011525618.1
- XM_011525634.1
- XM_011525621.1
- XM_011525637.1
- Sino Biological Human cDNA Clone for EPB41L3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EPB41L3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPB41L3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available EPB41L3 gene related products
- orf clones - Search results for available EPB41L3 gene related products
- Applied Biological Materials Clones for EPB41L3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for EPB41L3
-
ViGene Biosciences adenoviral particle packaged cDNA for EPB41L3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for EPB41L3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EPB41L3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPB41L3 Gene
Localization for EPB41L3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EPB41L3 Gene
- Cytoplasm, cytoskeleton. Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Detected in the cytoplasm of actively dividing cells.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| cytoskeleton | 4 |
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
- Plasma membrane (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IBA,IEA | -- |
| GO:0005886 | plasma membrane | IDA,NAS | 9892180 |
| GO:0005911 | cell-cell junction | IEA,IDA | 12234973 |
Pathways & Interactions for EPB41L3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Protein-protein interactions at synapses | ||
| 2 | Transmission across Chemical Synapses |
.62
|
|
Pathways by source for EPB41L3 Gene
3 Reactome pathways for EPB41L3 Gene
Interacting Proteins for EPB41L3 Gene
Selected Interacting proteins:
ENSP00000341138
Q9Y2J2-E41L3_HUMAN
for EPB41L3 Gene via
STRING
IID
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001558 | regulation of cell growth | IEA | -- |
| GO:0002175 | protein localization to paranode region of axon | ISS | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007010 | cytoskeleton organization | IEA | -- |
| GO:0007016 | cytoskeletal anchoring at plasma membrane | TAS,IEA | 21966409 |
No data available for SIGNOR curated interactions for EPB41L3 Gene
Transcripts for EPB41L3 Gene
mRNA/cDNA for EPB41L3 Gene
- (54) REFSEQ mRNAs :
- (19) Additional mRNA sequences :
- (188) Selected AceView cDNA sequences:
- (36) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for EPB41L3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for EPB41L3
- genomics-online: gRNA clones - Search results for available EPB41L3 gene related products
- Applied Biological Materials CRISPR for EPB41L3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPB41L3
- GenScript: Design CRISPR guide RNA sequences for EPB41L3
miRNA Products
- Search ViGene Biosciences for EPB41L3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for EPB41L3
- Browse OriGene Inhibitory RNA Products For EPB41L3
- genomics-online: shRNA clones - Search results for available EPB41L3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for EPB41L3 gene
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for EPB41L3 in any vector
- XM_011525624.1
- XM_011525608.1
- NM_001281535.1
- XM_011525611.1
- XM_011525627.1
- XM_011525614.1
- XM_011525630.1
- XM_011525617.1
- XM_011525633.1
- XM_011525620.1
- XM_011525636.1
- XM_011525623.1
- XM_011525607.1
- NM_001281534.1
- XM_011525626.1
- XM_011525610.1
- XM_011525613.1
- XM_011525629.1
- NM_012307.3
- XM_011525616.1
- XM_011525632.1
- XM_011525619.1
- XM_011525635.1
- XM_011525622.1
- XM_011525606.1
- NM_001281533.1
- XM_011525625.1
- XM_011525609.1
- XM_011525612.1
- XM_011525628.1
- XM_011525615.1
- XM_011525631.1
- XM_011525618.1
- XM_011525634.1
- XM_011525621.1
- XM_011525637.1
- Sino Biological Human cDNA Clone for EPB41L3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EPB41L3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPB41L3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available EPB41L3 gene related products
- orf clones - Search results for available EPB41L3 gene related products
- Applied Biological Materials Clones for EPB41L3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c | · | 15d | · | 15e | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP13: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - |
| ExUns: | 19a | · | 19b | · | 19c | ^ | 20a | · | 20b | · | 20c | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | · | 23c | ^ | 24a | · | 24b | ^ | 25a | · | 25b | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | · | 29c | · | 29d | · | 29e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP18: | - |
Expression for EPB41L3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
- Conjunctival Epithelium
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Brain (Nervous System)
- Neural Crest (Gastrulation Derivatives)
- Lateral Plate Mesoderm (Gastrulation Derivatives)
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Epithelial Cells
- Basal Cells Trachea
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Ovary (Reproductive System)
- Paraxial Mesoderm (Gastrulation Derivatives)
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
- Placenta (Extraembryonic Tissues)
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for EPB41L3 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.4).
This gene is overexpressed in Frontal cortex (30.3), Brain (14.6), and Spinal cord (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EPB41L3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of EPB41L3 Gene:
EPB41L3SOURCE GeneReport for Unigene cluster for EPB41L3 Gene:
Hs.213394mRNA Expression by UniProt/SwissProt for EPB41L3 Gene:
Q9Y2J2-E41L3_HUMAN
Tissue specificity:
Expressed at high levels in brain, with lower levels in kidney, intestine, and testis. Detected in lung.
Evidence on tissue expression from TISSUES for EPB41L3 Gene
- Nervous system(5)
- Lung(4.5)
- Liver(4.3)
- Kidney(2.5)
- Heart(2.3)
- Adrenal gland(2.2)
- Blood(2)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for EPB41L3
- genomics-online: primer clones - Search results for available EPB41L3 gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for EPB41L3 Gene
Orthologs for EPB41L3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EPB41L3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | EPB41L3 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | EPB41L3 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | EPB41L3 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Epb41l3 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | EPB41L3 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Epb4.1l3 33 34 |
|
||
| Epb41l3 16 |
|
||||
| chicken (Gallus gallus) |
Aves | EPB41L3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | EPB41L3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | epb41l3 33 |
|
||
| Str.17099 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | epb41l3b 33 34 |
|
||
| CABZ01090303.1 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | cora 35 34 |
|
||
| CG5022 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | frm-3 35 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for EPB41L3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for EPB41L3 Gene
Paralogs for EPB41L3 Gene
(15) SIMAP similar genes for EPB41L3 Gene using alignment to 16 proteins:
Variants for EPB41L3 Gene
| SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000005067 | -- | 5,458,837(-) | G/A | intron_variant | |
| rs1000011232 | -- | 5,506,630(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000015743 | -- | 5,498,567(-) | C/A/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000033492 | -- | 5,534,545(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000040442 | -- | 5,529,002(-) | G/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1543n106 | CNV | deletion | 24896259 |
| dgv184n21 | CNV | gain | 19592680 |
| dgv53n6 | CNV | deletion | 16902084 |
| dgv969e212 | CNV | loss | 25503493 |
| dgv970e212 | CNV | loss | 25503493 |
| esv2666529 | CNV | deletion | 23128226 |
| esv2671954 | CNV | deletion | 23128226 |
| esv2716715 | CNV | deletion | 23290073 |
| esv2716716 | CNV | deletion | 23290073 |
| esv2716717 | CNV | deletion | 23290073 |
| esv2716719 | CNV | deletion | 23290073 |
| esv3140456 | CNV | deletion | 24192839 |
| esv3211634 | CNV | deletion | 24192839 |
| esv3309085 | CNV | mobile element insertion | 20981092 |
| esv3353097 | CNV | insertion | 20981092 |
| esv3363246 | CNV | insertion | 20981092 |
| esv3439 | CNV | loss | 18987735 |
| esv3439162 | CNV | insertion | 20981092 |
| esv3554993 | CNV | deletion | 23714750 |
| esv989108 | CNV | deletion | 20482838 |
| esv998712 | CNV | deletion | 20482838 |
| nsv472411 | CNV | novel sequence insertion | 20440878 |
| nsv521827 | CNV | loss | 19592680 |
| nsv576393 | CNV | gain | 21841781 |
| nsv952407 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.49;
71.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EPB41L3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPB41L3 Gene
Disorders for EPB41L3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| benign meningioma |
|
|
| bejel |
|
|
| yaws |
|
|
| meningioma, familial |
|
|
| spinal cord ependymoma |
|
|
Search EPB41L3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for EPB41L3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for EPB41L3 Gene
Publications for EPB41L3 Gene
- A novel member of the NF2/ERM/4.1 superfamily with growth suppressing properties in lung cancer. (PMID: 9892180) Tran YK … Newsham IF (Cancer research 1999) 2 3 4 22 58
- The tumor suppressor DAL-1/4.1B and protein methylation cooperate in inducing apoptosis in MCF-7 breast cancer cells. (PMID: 16420693) Jiang W … Newsham IF (Molecular cancer 2006) 3 4 22 58
- DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo. (PMID: 15334060) Singh V … Newsham IF (Oncogene 2004) 3 4 22 58
- Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer. (PMID: 12234973) Yageta M … Murakami Y (Cancer research 2002) 3 4 22 58
- Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B). (PMID: 21131357) Busam RD … Hallberg BM (The Journal of biological chemistry 2011) 3 4 58
Products for EPB41L3 Gene
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- Invitrogen Antibodies for EPB41L3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 58 available EPB41L3 Antibodies ranked by validation data
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- GeneTex EPB41L3 antibody for EPB41L3
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- ViGene Biosciences adenoviral particle packaged cDNA for EPB41L3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for EPB41L3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for EPB41L3 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for EPB41L3
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- Santa Cruz Biotechnology (SCBT) CRISPR for EPB41L3
- Horizon Cell Lines for EPB41L3
- genomics-online: cdna clones - Search results for available EPB41L3 gene related products
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Sources for EPB41L3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
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- (109) DGIdb
- (110) ClinicalTrials
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- (114) diseasecard
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew