Aliases for EPB41L3 Gene
Aliases for EPB41L3 Gene
External Ids for EPB41L3 Gene
- HGNC: 3380
- Entrez Gene: 23136
- Ensembl: ENSG00000082397
- OMIM: 605331
- UniProtKB: Q9Y2J2
Previous GeneCards Identifiers for EPB41L3 Gene
- GC18P005437
- GC18M005456
Summaries for EPB41L3 Gene
GeneCards Summary for EPB41L3 Gene
EPB41L3 (Erythrocyte Membrane Protein Band 4.1 Like 3) is a Protein Coding gene. Diseases associated with EPB41L3 include Bejel and Spinal Cord Ependymoma. Among its related pathways are Protein-protein interactions at synapses and Transmission across Chemical Synapses. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is EPB41L2.
UniProtKB/Swiss-Prot for EPB41L3 Gene
-
Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPB41L3 Gene
Genomics for EPB41L3 Gene
Regulatory Elements for EPB41L3 Gene
Enhancers for EPB41L3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH18G005463 | 1.5 | FANTOM5 Ensembl ENCODE dbSUPER | 34.9 | +166.7 | 166729 | 1.9 | ZNF398 HIC1 PRDM6 ZNF366 GATA2 ZSCAN5C ZNF629 PRDM10 FOS | EPB41L3 ENSG00000265316 GC18P005502 |
| GH18G005460 | 1.4 | FANTOM5 Ensembl ENCODE dbSUPER | 30.7 | +168.9 | 168923 | 2.2 | PRDM6 SMARCA4 HLF FEZF1 PRDM4 ZNF843 SPI1 | EPB41L3 GC18P005456 ENSG00000265316 |
| GH18G005455 | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 22.2 | +174.0 | 174026 | 2.8 | CTCF ZNF654 JUN ZNF394 ZIC2 RAD21 ZNF335 GLIS2 GLIS1 SMC3 | EPB41L3 GC18P005456 GC18P005449 |
| GH18G005582 | 1.2 | FANTOM5 Ensembl ENCODE | 17.8 | +47.5 | 47531 | 2.3 | ZNF394 ZNF398 ZIC2 OSR2 SMARCA4 PATZ1 ZNF629 GLIS1 ZNF600 PRDM1 | EPB41L3 ENSG00000264000 |
| GH18G005542 | 1.2 | FANTOM5 ENCODE | 17 | +87.3 | 87300 | 2.5 | ZNF76 ZNF335 GLIS2 EGR2 SP3 ZNF398 PRDM6 SMARCA4 GLIS1 ZNF341 | EPB41L3 GC18P005557 GC18M005377 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around EPB41L3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for EPB41L3 Gene
- Chromosome:
- 18
- Start:
- 5,392,381 bp from pter
- End:
- 5,630,700 bp from pter
- Size:
- 238,320 bases
- Orientation:
- Minus strand
Genomic View for EPB41L3 Gene
Genes around EPB41L3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18p11.31 by Ensembl
- 18p11.31 by Entrez Gene
- 18p11.31 by HGNC
EPB41L3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EPB41L3 Gene
Proteins for EPB41L3 Gene
-
Protein details for EPB41L3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y2J2-E41L3_HUMAN
- Recommended name:
- Band 4.1-like protein 3
- Protein Accession:
- Q9Y2J2
- B7Z4I5
- F5GX05
- O95713
- Q9BRP5
Protein attributes for EPB41L3 Gene
- Size:
- 1087 amino acids
- Molecular mass:
- 120678 Da
- Quaternary structure:
-
- Interacts (via FERM domain) with CADM1. Interacts with PRMT3, PRMT5 and PRMT6.
- SequenceCaution:
-
- Sequence=AAC79806.1; Type=Frameshift; Positions=29, 59; Evidence={ECO:0000305}; Sequence=BAA76831.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for EPB41L3 Gene
Post-translational modifications for EPB41L3 Gene
Other Protein References for EPB41L3 Gene
- ENSEMBL proteins:
-
- ENSP00000343158
- ENSP00000382981
- ENSP00000441174
- ENSP00000442091
- ENSP00000461937
- ENSP00000462338
- ENSP00000462692
- ENSP00000462783
- ENSP00000463122
- ENSP00000463289
- ENSP00000463707
- ENSP00000464020
- ENSP00000464148
- ENSP00000464336
- ENSP00000464533
- ENSP00000464570
- ENSP00000487780
- ENSP00000487786
- ENSP00000487915
- ENSP00000488037
- ENSP00000488095
- ENSP00000488626
- ENSP00000488647
- ENSP00000489405
- ENSP00000489681
- ENSP00000341138
- REFSEQ proteins:
-
- NP_001268462.1
- NP_001268463.1
- NP_001268464.1
- NP_001317486.1
- NP_036439.2
- XP_011523925.1
- XP_011523928.1
- XP_011523930.1
- XP_011523934.1
- XP_011523936.1
- XP_011523939.1
- XP_016881107.1
- XP_016881108.1
- XP_016881109.1
- XP_016881110.1
- XP_016881111.1
- XP_016881112.1
- XP_016881113.1
- XP_016881114.1
- XP_016881115.1
- XP_016881116.1
- XP_016881117.1
- XP_016881118.1
- XP_016881119.1
- XP_016881120.1
- XP_016881121.1
- XP_016881122.1
- XP_016881123.1
- XP_016881124.1
- XP_016881125.1
- XP_016881126.1
- XP_016881127.1
- XP_016881128.1
- XP_016881129.1
- XP_016881130.1
- XP_016881131.1
- XP_016881132.1
- XP_016881133.1
- XP_016881134.1
- XP_016881135.1
- XP_016881136.1
- XP_016881137.1
- XP_016881138.1
- XP_016881139.1
- XP_016881140.1
- XP_016881141.1
- XP_016881142.1
- XP_016881143.1
- XP_016881144.1
- XP_016881145.1
- XP_016881146.1
- XP_016881147.1
- XP_016881148.1
- XP_016881149.1
Antibody Products
- Novus Biologicals Antibodies for EPB41L3
- Invitrogen Antibodies for EPB41L3
- antibodies-online Antibodies for EPB41L3: See all 40
- GeneTex EPB41L3 antibody for EPB41L3
-
Santa Cruz Biotechnology (SCBT) Antibodies for EPB41L3
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for EPB41L3
- Origene Custom Protein Services for EPB41L3
- antibodies-online Proteins for EPB41L3: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for EPB41L3
Assay Products
- antibodies-online Kits for EPB41L3: See all 5
No data available for DME Specific Peptides for EPB41L3 Gene
Domains & Families for EPB41L3 Gene
Gene Families for EPB41L3 Gene
Protein Domains for EPB41L3 Gene
Suggested Antigen Peptide Sequences for EPB41L3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for EPB41L3 Gene
Function for EPB41L3 Gene
Molecular function for EPB41L3 Gene
- GENATLAS Biochemistry:
- erythrocyte surface protein 4.1-like 3,expressed in the brain
- UniProtKB/Swiss-Prot Function:
- Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
| GO:0005198 | structural molecule activity | IEA | -- |
| GO:0005200 | structural constituent of cytoskeleton | TAS | 21966409 |
| GO:0005515 | protein binding | IPI | 12234973 |
| GO:0008092 | cytoskeletal protein binding | IEA | -- |
Phenotypes for EPB41L3 Gene
- MGI mutant phenotypes for EPB41L3:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for EPB41L3:
Animal Models for EPB41L3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EPB41L3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for EPB41L3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EPB41L3 gene
- Search ViGene Biosciences for EPB41L3
CRISPR Products
-
OriGene CRISPR knockouts for EPB41L3
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPB41L3
- GenScript: Design CRISPR guide RNA sequences for EPB41L3
miRNA for EPB41L3 Gene
- miRTarBase miRNAs that target EPB41L3
-
- hsa-mir-223-3p (MIRT006374)
- hsa-mir-877-3p (MIRT037171)
- hsa-mir-92a-3p (MIRT049330)
- hsa-let-7b-5p (MIRT051992)
- hsa-mir-1305 (MIRT551184)
- hsa-mir-498 (MIRT551185)
- hsa-mir-4465 (MIRT551186)
- hsa-mir-26b-5p (MIRT551187)
- hsa-mir-26a-5p (MIRT551188)
- hsa-mir-1297 (MIRT551189)
- hsa-mir-627-3p (MIRT551190)
- hsa-mir-4275 (MIRT551191)
- hsa-mir-5697 (MIRT551192)
- hsa-mir-551b-5p (MIRT551193)
- hsa-mir-548c-3p (MIRT551194)
- hsa-mir-4684-5p (MIRT637420)
- hsa-mir-3675-3p (MIRT637421)
- hsa-mir-4524b-3p (MIRT637422)
- hsa-mir-7161-5p (MIRT637423)
- hsa-mir-548u (MIRT637424)
miRNA Products
- Search ViGene Biosciences for EPB41L3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for EPB41L3
- Browse OriGene Inhibitory RNA Products For EPB41L3
-
ViGene Biosciences ready-to-package AAV shRNAs for EPB41L3 gene
Clone Products
-
GenScript: Next-day shipping cDNA ORF clone for EPB41L3 in any vector
- XM_011525606
- XM_011525607
- XM_011525608
- XM_011525609
- XM_011525610
- XM_011525611
- XM_011525612
- XM_011525613
- XM_011525614
- XM_011525615
- XM_011525616
- XM_011525617
- XM_011525618
- XM_011525619
- XM_011525620
- XM_011525621
- XM_011525622
- XM_011525623
- XM_011525624
- XM_011525625
- XM_011525626
- XM_011525627
- XM_011525628
- XM_011525629
- XM_011525630
- XM_011525631
- XM_011525632
- XM_011525633
- XM_011525634
- XM_011525635
- XM_011525636
- XM_011525637
- NM_012307
- NM_001281533
- NM_001281534
- NM_001281535
- Sino Biological Human cDNA Clone for EPB41L3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EPB41L3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPB41L3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for EPB41L3
-
ViGene Biosciences adenoviral particle packaged cDNA for EPB41L3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for EPB41L3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EPB41L3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPB41L3 Gene
Localization for EPB41L3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EPB41L3 Gene
- Cytoplasm, cytoskeleton. Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Detected in the cytoplasm of actively dividing cells.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| cytoskeleton | 4 |
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IBA,IEA | -- |
| GO:0005886 | plasma membrane | NAS,IEA | 9892180 |
| GO:0005911 | cell-cell junction | IDA,IEA | 12234973 |
Pathways & Interactions for EPB41L3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Protein-protein interactions at synapses | ||
| 2 | Transmission across Chemical Synapses |
.62
|
|
Pathways by source for EPB41L3 Gene
3 Reactome pathways for EPB41L3 Gene
Interacting Proteins for EPB41L3 Gene
Selected Interacting proteins:
Q9Y2J2-E41L3_HUMAN
ENSP00000341138
for EPB41L3 Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001558 | regulation of cell growth | IEA | -- |
| GO:0002175 | protein localization to paranode region of axon | ISS | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007010 | cytoskeleton organization | IEA | -- |
| GO:0007016 | cytoskeletal anchoring at plasma membrane | TAS,IEA | 21966409 |
No data available for SIGNOR curated interactions for EPB41L3 Gene
Transcripts for EPB41L3 Gene
mRNA/cDNA for EPB41L3 Gene
- (54) REFSEQ mRNAs :
- (19) Additional mRNA sequences :
- (188) Selected AceView cDNA sequences:
- (36) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for EPB41L3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for EPB41L3
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPB41L3
- GenScript: Design CRISPR guide RNA sequences for EPB41L3
miRNA Products
- Search ViGene Biosciences for EPB41L3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for EPB41L3
- Browse OriGene Inhibitory RNA Products For EPB41L3
-
ViGene Biosciences ready-to-package AAV shRNAs for EPB41L3 gene
Clone Products
-
GenScript: Next-day shipping cDNA ORF clone for EPB41L3 in any vector
- XM_011525606
- XM_011525607
- XM_011525608
- XM_011525609
- XM_011525610
- XM_011525611
- XM_011525612
- XM_011525613
- XM_011525614
- XM_011525615
- XM_011525616
- XM_011525617
- XM_011525618
- XM_011525619
- XM_011525620
- XM_011525621
- XM_011525622
- XM_011525623
- XM_011525624
- XM_011525625
- XM_011525626
- XM_011525627
- XM_011525628
- XM_011525629
- XM_011525630
- XM_011525631
- XM_011525632
- XM_011525633
- XM_011525634
- XM_011525635
- XM_011525636
- XM_011525637
- NM_012307
- NM_001281533
- NM_001281534
- NM_001281535
- Sino Biological Human cDNA Clone for EPB41L3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EPB41L3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPB41L3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c | · | 15d | · | 15e | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - |
| ExUns: | 19a | · | 19b | · | 19c | ^ | 20a | · | 20b | · | 20c | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | · | 23c | ^ | 24a | · | 24b | ^ | 25a | · | 25b | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | · | 29c | · | 29d | · | 29e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP18: | - |
Expression for EPB41L3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
- Conjunctival Epithelium
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Brain (Nervous System)
- Neural Crest (Gastrulation Derivatives)
- Lateral Plate Mesoderm (Gastrulation Derivatives)
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Epithelial Cells
- Basal Cells Trachea
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Ovary (Reproductive System)
- Paraxial Mesoderm (Gastrulation Derivatives)
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
- Placenta (Extraembryonic Tissues)
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for EPB41L3 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.4).
This gene is overexpressed in Frontal cortex (30.3), Brain (14.6), and Spinal cord (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EPB41L3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of EPB41L3 Gene:
EPB41L3SOURCE GeneReport for Unigene cluster for EPB41L3 Gene:
Hs.213394mRNA Expression by UniProt/SwissProt for EPB41L3 Gene:
Q9Y2J2-E41L3_HUMAN
Tissue specificity:
Expressed at high levels in brain, with lower levels in kidney, intestine, and testis. Detected in lung.
Evidence on tissue expression from TISSUES for EPB41L3 Gene
- Nervous system(5)
- Lung(4.5)
- Liver(4.3)
- Kidney(2.5)
- Heart(2.3)
- Adrenal gland(2.2)
- Blood(2)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for EPB41L3
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for EPB41L3 Gene
Orthologs for EPB41L3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EPB41L3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | EPB41L3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | EPB41L3 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | EPB41L3 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Epb41l3 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | EPB41L3 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Epb4.1l3 34 35 |
|
||
| Epb41l3 16 |
|
||||
| chicken (Gallus gallus) |
Aves | EPB41L3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | EPB41L3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | epb41l3 34 |
|
||
| Str.17099 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | epb41l3b 34 35 |
|
||
| CABZ01090303.1 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | cora 36 35 |
|
||
| CG5022 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | frm-3 36 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for EPB41L3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for EPB41L3 Gene
Paralogs for EPB41L3 Gene
(15) SIMAP similar genes for EPB41L3 Gene using alignment to 16 proteins:
Variants for EPB41L3 Gene
| SNP ID | Clin | Chr 18 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000005067 | -- | 5,458,837(+) | TTGAG(A/G)TTATC | intron-variant | |
| rs1000011232 | -- | 5,506,630(+) | CAGAG(A/G)CTCTA | intron-variant | |
| rs1000015743 | -- | 5,498,567(+) | CCTGC(A/C/T)TGGGT | intron-variant | |
| rs1000033492 | -- | 5,534,545(+) | TTTGC(A/G)AACCT | intron-variant | |
| rs1000040442 | -- | 5,529,002(+) | ATCAA(C/G)AATAT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1543n106 | CNV | deletion | 24896259 |
| dgv184n21 | CNV | gain | 19592680 |
| dgv53n6 | CNV | deletion | 16902084 |
| dgv969e212 | CNV | loss | 25503493 |
| dgv970e212 | CNV | loss | 25503493 |
| esv2666529 | CNV | deletion | 23128226 |
| esv2671954 | CNV | deletion | 23128226 |
| esv2716715 | CNV | deletion | 23290073 |
| esv2716716 | CNV | deletion | 23290073 |
| esv2716717 | CNV | deletion | 23290073 |
| esv2716719 | CNV | deletion | 23290073 |
| esv3140456 | CNV | deletion | 24192839 |
| esv3211634 | CNV | deletion | 24192839 |
| esv3309085 | CNV | mobile element insertion | 20981092 |
| esv3353097 | CNV | insertion | 20981092 |
| esv3363246 | CNV | insertion | 20981092 |
| esv3439 | CNV | loss | 18987735 |
| esv3439162 | CNV | insertion | 20981092 |
| esv3554993 | CNV | deletion | 23714750 |
| esv989108 | CNV | deletion | 20482838 |
| esv998712 | CNV | deletion | 20482838 |
| nsv472411 | CNV | novel sequence insertion | 20440878 |
| nsv521827 | CNV | loss | 19592680 |
| nsv576393 | CNV | gain | 21841781 |
| nsv952407 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.49;
71.78% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for EPB41L3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPB41L3 Gene
Disorders for EPB41L3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bejel |
|
|
| spinal cord ependymoma |
|
|
| meningioma, familial |
|
|
| neurofibromatosis, type 2 |
|
|
| clear cell ependymoma |
|
|
Search EPB41L3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for EPB41L3
No data available for UniProtKB/Swiss-Prot and Genatlas for EPB41L3 Gene
Publications for EPB41L3 Gene
- A novel member of the NF2/ERM/4.1 superfamily with growth suppressing properties in lung cancer. (PMID: 9892180) Tran Y.K. … Newsham I.F. (Cancer Res. 1999) 2 3 4 22 64
- The tumor suppressor DAL-1/4.1B and protein methylation cooperate in inducing apoptosis in MCF-7 breast cancer cells. (PMID: 16420693) Jiang W. … Newsham I.F. (Mol. Cancer 2006) 3 4 22 64
- DAL-1/4.1B tumor suppressor interacts with protein arginine N- methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo. (PMID: 15334060) Singh V. … Newsham I.F. (Oncogene 2004) 3 4 22 64
- Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer. (PMID: 12234973) Yageta M. … Murakami Y. (Cancer Res. 2002) 3 4 22 64
- Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL- 1/4.1B). (PMID: 21131357) Busam R.D. … Hallberg B.M. (J. Biol. Chem. 2011) 3 4 64
Products for EPB41L3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for EPB41L3
- Origene Custom Protein Services for EPB41L3
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for EPB41L3
- Browse OriGene Inhibitory RNA Products For EPB41L3
- OriGene qPCR primer pairs for EPB41L3
- OriGene CRISPR knockouts for EPB41L3
- OriGene ORF clones in human for EPB41L3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For EPB41L3
- GenScript: Next-day shipping cDNA ORF clone for EPB41L3 in any vector
- XM_011525606
- XM_011525607
- XM_011525608
- XM_011525609
- XM_011525610
- XM_011525611
- XM_011525612
- XM_011525613
- XM_011525614
- XM_011525615
- XM_011525616
- XM_011525617
- XM_011525618
- XM_011525619
- XM_011525620
- XM_011525621
- XM_011525622
- XM_011525623
- XM_011525624
- XM_011525625
- XM_011525626
- XM_011525627
- XM_011525628
- XM_011525629
- XM_011525630
- XM_011525631
- XM_011525632
- XM_011525633
- XM_011525634
- XM_011525635
- XM_011525636
- XM_011525637
- NM_012307
- NM_001281533
- NM_001281534
- NM_001281535
- GenScript Custom Purified and Recombinant Proteins Services for EPB41L3
- GenScript Custom Assay Services for EPB41L3
- GenScript Custom overexpressing Cell Line Services for EPB41L3
- GenScript: Design CRISPR guide RNA sequences for EPB41L3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for EPB41L3
- Sino Biological Human cDNA Clone for EPB41L3
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for EPB41L3
- Novus Biologicals proteins and lysates for EPB41L3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for EPB41L3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for EPB41L3: See all 40
- antibodies-online Kits for EPB41L3: See all 5
- antibodies-online Proteins for EPB41L3: See all 3
- Search antibodies-online for peptides
- GeneTex EPB41L3 antibody for EPB41L3
- Search GeneTex for Proteins for EPB41L3
- ViGene Biosciences adenoviral particle packaged cDNA for EPB41L3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for EPB41L3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for EPB41L3 gene
- Search ViGene Biosciences for EPB41L3
- Santa Cruz Biotechnology (SCBT) Antibodies for EPB41L3
- Search Santa Cruz Biotechnology (SCBT) for EPB41L3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EPB41L3
- Horizon Cell Lines for EPB41L3
- Cyagen custom Knockout/knockin (KOKI) mouse models for EPB41L3
- VectorBuilder custom plasmid, inducible vectors for EPB41L3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPB41L3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for EPB41L3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer