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Aliases for EPB41L3 Gene

Aliases for EPB41L3 Gene

  • Erythrocyte Membrane Protein Band 4.1-Like 3 2 3
  • DAL1 3 4 6
  • Differentially Expressed In Adenocarcinoma Of The Lung Protein 1 3 4
  • DAL-1 3 4
  • 4.1B 3 4
  • Band 4.1-Like Protein 3 3
  • KIAA0987 4

External Ids for EPB41L3 Gene

Summaries for EPB41L3 Gene

GeneCards Summary for EPB41L3 Gene

EPB41L3 (Erythrocyte Membrane Protein Band 4.1-Like 3) is a Protein Coding gene. Diseases associated with EPB41L3 include adenocarcinoma and benign meningioma. Among its related pathways are Tight junction. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is FRMD3.

UniProtKB/Swiss-Prot for EPB41L3 Gene

  • Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.

Gene Wiki entry for EPB41L3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPB41L3 Gene

Genomics for EPB41L3 Gene

Genomic Location for EPB41L3 Gene

Start:
5,392,381 bp from pter
End:
5,630,700 bp from pter
Size:
238,320 bases
Orientation:
Minus strand

Genomic View for EPB41L3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPB41L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPB41L3 Gene

Regulatory Elements for EPB41L3 Gene

Proteins for EPB41L3 Gene

  • Protein details for EPB41L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2J2-E41L3_HUMAN
    Recommended name:
    Band 4.1-like protein 3
    Protein Accession:
    Q9Y2J2
    Secondary Accessions:
    • B7Z4I5
    • F5GX05
    • O95713
    • Q9BRP5

    Protein attributes for EPB41L3 Gene

    Size:
    1087 amino acids
    Molecular mass:
    120678 Da
    Quaternary structure:
    • Interacts (via FERM domain) with CADM1. Interacts with PRMT3, PRMT5 and PRMT6.
    SequenceCaution:
    • Sequence=AAC79806.1; Type=Frameshift; Positions=29, 59; Evidence={ECO:0000305}; Sequence=BAA76831.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EPB41L3 Gene

    Alternative splice isoforms for EPB41L3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPB41L3 Gene

Proteomics data for EPB41L3 Gene at MOPED

Post-translational modifications for EPB41L3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys75, Lys138, Lys162, Lys336, Lys397, Lys398, and Lys405

No data available for DME Specific Peptides for EPB41L3 Gene

Domains for EPB41L3 Gene

UniProtKB/Swiss-Prot:

E41L3_HUMAN
Domain:
  • Contains 1 FERM domain.:
    • Q9Y2J2
genes like me logo Genes that share domains with EPB41L3: view

No data available for Gene Families for EPB41L3 Gene

Function for EPB41L3 Gene

Molecular function for EPB41L3 Gene

GENATLAS Biochemistry: erythrocyte surface protein 4.1-like 3,expressed in the brain
UniProtKB/Swiss-Prot Function: Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.

Gene Ontology (GO) - Molecular Function for EPB41L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005198 structural molecule activity --
GO:0005200 structural constituent of cytoskeleton TAS 21966409
GO:0005515 protein binding IPI 12234973
GO:0008092 cytoskeletal protein binding --
genes like me logo Genes that share ontologies with EPB41L3: view
genes like me logo Genes that share phenotypes with EPB41L3: view

Animal Models for EPB41L3 Gene

MGI Knock Outs for EPB41L3:

miRNA for EPB41L3 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for EPB41L3 Gene

Localization for EPB41L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPB41L3 Gene

Cytoplasm, cytoskeleton. Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Detected in the cytoplasm of actively dividing cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPB41L3 Gene COMPARTMENTS Subcellular localization image for EPB41L3 gene
Compartment Confidence
plasma membrane 5
cytosol 3
cytoskeleton 2
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for EPB41L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane NAS 9892180
GO:0005911 cell-cell junction IDA 12234973
GO:0019898 extrinsic component of membrane IEA --
genes like me logo Genes that share ontologies with EPB41L3: view

Pathways for EPB41L3 Gene

SuperPathways for EPB41L3 Gene

Superpath Contained pathways
1 Tight junction
genes like me logo Genes that share pathways with EPB41L3: view

Pathways by source for EPB41L3 Gene

1 KEGG pathway for EPB41L3 Gene

Gene Ontology (GO) - Biological Process for EPB41L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002175 protein localization to paranode region of axon ISS --
GO:0006915 apoptotic process IEA --
GO:0007016 cytoskeletal anchoring at plasma membrane TAS 21966409
GO:0008150 biological_process ND --
GO:0008360 regulation of cell shape ISS --
genes like me logo Genes that share ontologies with EPB41L3: view

Compounds for EPB41L3 Gene

(3) Novoseek inferred chemical compound relationships for EPB41L3 Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 67.2 4
progesterone 15.4 2
thymidine 8.69 2
genes like me logo Genes that share compounds with EPB41L3: view

Transcripts for EPB41L3 Gene

Unigene Clusters for EPB41L3 Gene

Erythrocyte membrane protein band 4.1-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPB41L3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - - - -
SP2: - - -
SP3: - - - - - - - - - - - - - - - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - - -
SP8: - - -
SP9: -
SP10:
SP11:
SP12:
SP13: - - -
SP14: -
SP15:
SP16: - -
SP17: - - - -
SP18: -

ExUns: 19a · 19b · 19c ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c · 29d · 29e
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - - - - - - -
SP4: - - - - -
SP5:
SP6: - - - - -
SP7: - - - - - -
SP8: - - -
SP9: -
SP10:
SP11: - -
SP12:
SP13: - - - - - - - - - - -
SP14: - - - - - - -
SP15: -
SP16:
SP17: - - - - - - -
SP18: -

Relevant External Links for EPB41L3 Gene

GeneLoc Exon Structure for
EPB41L3
ECgene alternative splicing isoforms for
EPB41L3

Expression for EPB41L3 Gene

mRNA expression in normal human tissues for EPB41L3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPB41L3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EPB41L3 Gene

SOURCE GeneReport for Unigene cluster for EPB41L3 Gene Hs.213394

mRNA Expression by UniProt/SwissProt for EPB41L3 Gene

Q9Y2J2-E41L3_HUMAN
Tissue specificity: Expressed at high levels in brain, with lower levels in kidney, intestine, and testis. Detected in lung.
genes like me logo Genes that share expressions with EPB41L3: view

Orthologs for EPB41L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPB41L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPB41L3 36
  • 99.23 (n)
  • 98.9 (a)
EPB41L3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EPB41L3 36
  • 86.67 (n)
  • 90.05 (a)
EPB41L3 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPB41L3 36
  • 89.11 (n)
  • 91.79 (a)
EPB41L3 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Epb4.1l3 36
  • 83.35 (n)
  • 88.12 (a)
Epb4.1l3 16
Epb4.1l3 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EPB41L3 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EPB41L3 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Epb41l3 36
  • 84.58 (n)
  • 88.23 (a)
chicken
(Gallus gallus)
Aves EPB41L3 36
  • 78.95 (n)
  • 83 (a)
EPB41L3 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPB41L3 37
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia epb41l3 36
  • 73.88 (n)
  • 76.64 (a)
Str.17099 36
zebrafish
(Danio rerio)
Actinopterygii CABZ01090303.1 37
  • 45 (a)
OneToMany
epb41l3b 36
  • 63.38 (n)
  • 66.58 (a)
epb41l3b 37
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta cora 37
  • 21 (a)
OneToMany
CG5022 38
  • 36 (a)
cora 38
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea frm-3 38
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 60 (a)
OneToMany
Species with no ortholog for EPB41L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EPB41L3 Gene

ENSEMBL:
Gene Tree for EPB41L3 (if available)
TreeFam:
Gene Tree for EPB41L3 (if available)

Paralogs for EPB41L3 Gene

genes like me logo Genes that share paralogs with EPB41L3: view

Variants for EPB41L3 Gene

Sequence variations from dbSNP and Humsavar for EPB41L3 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs3638 -- 5,544,831(-) AAATC(C/T)ATCCT upstream-variant-2KB, intron-variant
rs721565 -- 5,621,018(+) GCCAG(C/G)TGGAC intron-variant
rs879315 -- 5,446,890(+) CATTT(A/G)TTTAT intron-variant
rs940130 -- 5,601,737(+) TTTAC(A/G)TCTGT intron-variant
rs940131 -- 5,575,355(-) CATTC(A/G)TGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPB41L3 Gene

Variant ID Type Subtype PubMed ID
dgv184n21 CNV Gain 19592680
esv273358 CNV Insertion 20981092
esv2716715 CNV Deletion 23290073
esv3439 CNV Deletion 18987735
esv2671954 CNV Deletion 23128226
dgv53n6 CNV Loss 16902084
esv989108 CNV Deletion 20482838
esv2716716 CNV Deletion 23290073
esv2716717 CNV Deletion 23290073
esv2716719 CNV Deletion 23290073
esv2666529 CNV Deletion 23128226
nsv521827 CNV Loss 19592680

Relevant External Links for EPB41L3 Gene

HapMap Linkage Disequilibrium report
EPB41L3

Disorders for EPB41L3 Gene

(13) Novoseek inferred disease relationships for EPB41L3 Gene

Disease -log(P) Hits PubMed IDs
neurofibromatosis type 2 76.2 4
meningioma 75.7 31
benign meningioma 67.1 1
carcinoma non-small cell lung 55.3 4
adenocarcinoma 53.5 14

Relevant External Links for EPB41L3

Genetic Association Database (GAD)
EPB41L3
Human Genome Epidemiology (HuGE) Navigator
EPB41L3
genes like me logo Genes that share disorders with EPB41L3: view

No data available for UniProtKB/Swiss-Prot for EPB41L3 Gene

Publications for EPB41L3 Gene

  1. A novel member of the NF2/ERM/4.1 superfamily with growth suppressing properties in lung cancer. (PMID: 9892180) Tran Y.K. … Newsham I.F. (Cancer Res. 1999) 2 3 4 23
  2. Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer. (PMID: 12234973) Yageta M. … Murakami Y. (Cancer Res. 2002) 3 4 23
  3. DAL-1/4.1B tumor suppressor interacts with protein arginine N- methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo. (PMID: 15334060) Singh V. … Newsham I.F. (Oncogene 2004) 3 4 23
  4. The tumor suppressor DAL-1/4.1B and protein methylation cooperate in inducing apoptosis in MCF-7 breast cancer cells. (PMID: 16420693) Jiang W. … Newsham I.F. (Mol. Cancer 2006) 3 4 23
  5. Membrane localization of the U2 domain of Protein 4.1B is necessary and sufficient for meningioma growth suppression. (PMID: 15688033) Robb V.A. … Gutmann D.H. (Oncogene 2005) 3 23

Products for EPB41L3 Gene

Sources for EPB41L3 Gene

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