Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EPB41L3 Gene

Aliases for EPB41L3 Gene

  • Erythrocyte Membrane Protein Band 4.1 Like 3 2 3 5
  • Differentially Expressed In Adenocarcinoma Of The Lung Protein 1 3 4
  • DAL-1 3 4
  • 4.1B 3 4
  • DAL1 3 4
  • Band 4.1-Like Protein 3 3
  • KIAA0987 4

External Ids for EPB41L3 Gene

Previous GeneCards Identifiers for EPB41L3 Gene

  • GC18P005437
  • GC18M005456

Summaries for EPB41L3 Gene

GeneCards Summary for EPB41L3 Gene

EPB41L3 (Erythrocyte Membrane Protein Band 4.1 Like 3) is a Protein Coding gene. Diseases associated with EPB41L3 include Bejel and Lung Cancer. Among its related pathways are Protein-protein interactions at synapses and Tight junction. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is EPB41L2.

UniProtKB/Swiss-Prot for EPB41L3 Gene

  • Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.

Gene Wiki entry for EPB41L3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPB41L3 Gene

Genomics for EPB41L3 Gene

Regulatory Elements for EPB41L3 Gene

Enhancers for EPB41L3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F005460 1.3 FANTOM5 Ensembl ENCODE 38.3 +166.8 166813 6.4 HLF FEZF1 ZNF843 HIC1 ZNF366 SMARCA4 ZNF302 PRDM10 SPI1 EPB41L3 ENSG00000265316 GC18P005502
GH18F005455 1.3 FANTOM5 Ensembl ENCODE 22.2 +174.0 174026 2.8 CTCF ZNF654 JUN ZIC2 RAD21 ZNF335 GLIS2 GLIS1 PRDM10 EPB41L3 GC18P005456 GC18P005449
GH18F005582 1.2 FANTOM5 Ensembl ENCODE 17.8 +47.5 47531 2.3 OSR2 SMARCA4 GLIS1 PATZ1 ZNF600 ZIC2 PRDM1 EPB41L3 ENSG00000264000
GH18F005542 1.2 FANTOM5 ENCODE 17 +87.3 87300 2.5 KLF1 ZNF76 ZNF223 ZNF335 HIC1 ZFHX2 GLIS2 ZBTB48 POLR2A PATZ1 EPB41L3 GC18P005557 GC18M005377
GH18F005513 1.2 FANTOM5 Ensembl ENCODE 12.4 +115.4 115441 3.1 ZNF263 HIC1 ZNF366 SMARCA4 POLR2A SCRT2 ZBTB20 ZXDB SP7 EPB41L3 GC18M005377 GC18P005502
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EPB41L3 on UCSC Golden Path with GeneCards custom track

Promoters for EPB41L3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000521657 1100 2800 PKNOX1 GLI4 ZNF2 ZNF121 GLIS2 KLF7 ZNF263 SP3 REST SMARCA4

Genomic Location for EPB41L3 Gene

Chromosome:
18
Start:
5,392,381 bp from pter
End:
5,630,700 bp from pter
Size:
238,320 bases
Orientation:
Minus strand

Genomic View for EPB41L3 Gene

Genes around EPB41L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPB41L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPB41L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPB41L3 Gene

Proteins for EPB41L3 Gene

  • Protein details for EPB41L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2J2-E41L3_HUMAN
    Recommended name:
    Band 4.1-like protein 3
    Protein Accession:
    Q9Y2J2
    Secondary Accessions:
    • B7Z4I5
    • F5GX05
    • O95713
    • Q9BRP5

    Protein attributes for EPB41L3 Gene

    Size:
    1087 amino acids
    Molecular mass:
    120678 Da
    Quaternary structure:
    • Interacts (via FERM domain) with CADM1. Interacts with PRMT3, PRMT5 and PRMT6.
    SequenceCaution:
    • Sequence=AAC79806.1; Type=Frameshift; Positions=29, 59; Evidence={ECO:0000305}; Sequence=BAA76831.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EPB41L3 Gene

    Alternative splice isoforms for EPB41L3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPB41L3 Gene

Post-translational modifications for EPB41L3 Gene

  • Ubiquitination at Lys 75, Lys 162, Lys 336, and Lys 397
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for EPB41L3 Gene

Domains & Families for EPB41L3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2J2

UniProtKB/Swiss-Prot:

E41L3_HUMAN :
  • Contains 1 FERM domain.
Domain:
  • Contains 1 FERM domain.
genes like me logo Genes that share domains with EPB41L3: view

Function for EPB41L3 Gene

Molecular function for EPB41L3 Gene

GENATLAS Biochemistry:
erythrocyte surface protein 4.1-like 3,expressed in the brain
UniProtKB/Swiss-Prot Function:
Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5.

Gene Ontology (GO) - Molecular Function for EPB41L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005198 structural molecule activity IEA --
GO:0005200 structural constituent of cytoskeleton TAS 21966409
GO:0005515 protein binding IPI 12234973
GO:0008092 cytoskeletal protein binding IEA --
genes like me logo Genes that share ontologies with EPB41L3: view
genes like me logo Genes that share phenotypes with EPB41L3: view

Animal Models for EPB41L3 Gene

MGI Knock Outs for EPB41L3:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPB41L3 Gene

Localization for EPB41L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPB41L3 Gene

Cytoplasm, cytoskeleton. Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Detected in the cytoplasm of actively dividing cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EPB41L3 gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 4
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for EPB41L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA,IBA --
GO:0005886 plasma membrane IEA,NAS 9892180
GO:0005911 cell-cell junction IEA,IDA 12234973
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with EPB41L3: view

Pathways & Interactions for EPB41L3 Gene

genes like me logo Genes that share pathways with EPB41L3: view

Pathways by source for EPB41L3 Gene

Gene Ontology (GO) - Biological Process for EPB41L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0002175 protein localization to paranode region of axon ISS --
GO:0006915 apoptotic process IEA --
GO:0007010 cytoskeleton organization IEA --
GO:0007016 cytoskeletal anchoring at plasma membrane IEA,TAS 21966409
genes like me logo Genes that share ontologies with EPB41L3: view

No data available for SIGNOR curated interactions for EPB41L3 Gene

Drugs & Compounds for EPB41L3 Gene

(2) Drugs for EPB41L3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for EPB41L3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EPB41L3: view

Transcripts for EPB41L3 Gene

Unigene Clusters for EPB41L3 Gene

Erythrocyte membrane protein band 4.1-like 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPB41L3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - - - -
SP2: - - -
SP3: - - - - - - - - - - - - - - - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - - -
SP8: - - -
SP9: -
SP10:
SP11:
SP12:
SP13: - - -
SP14: -
SP15:
SP16: - -
SP17: - - - -
SP18: -

ExUns: 19a · 19b · 19c ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c · 29d · 29e
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - - - - - - - -
SP4: - - - - -
SP5:
SP6: - - - - -
SP7: - - - - - -
SP8: - - -
SP9: -
SP10:
SP11: - -
SP12:
SP13: - - - - - - - - - - -
SP14: - - - - - - -
SP15: -
SP16:
SP17: - - - - - - -
SP18: -

Relevant External Links for EPB41L3 Gene

GeneLoc Exon Structure for
EPB41L3
ECgene alternative splicing isoforms for
EPB41L3

Expression for EPB41L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EPB41L3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPB41L3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.4).

Protein differential expression in normal tissues from HIPED for EPB41L3 Gene

This gene is overexpressed in Frontal cortex (30.3), Brain (14.6), and Spinal cord (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EPB41L3 Gene



Protein tissue co-expression partners for EPB41L3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EPB41L3 Gene:

EPB41L3

SOURCE GeneReport for Unigene cluster for EPB41L3 Gene:

Hs.213394

mRNA Expression by UniProt/SwissProt for EPB41L3 Gene:

Q9Y2J2-E41L3_HUMAN
Tissue specificity: Expressed at high levels in brain, with lower levels in kidney, intestine, and testis. Detected in lung.
genes like me logo Genes that share expression patterns with EPB41L3: view

Primer Products

Orthologs for EPB41L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPB41L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPB41L3 34 35
  • 99.23 (n)
dog
(Canis familiaris)
Mammalia EPB41L3 34 35
  • 89.11 (n)
cow
(Bos Taurus)
Mammalia EPB41L3 34 35
  • 86.67 (n)
oppossum
(Monodelphis domestica)
Mammalia EPB41L3 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Epb41l3 34
  • 84.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EPB41L3 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Epb4.1l3 34 35
  • 83.35 (n)
Epb41l3 16
chicken
(Gallus gallus)
Aves EPB41L3 34 35
  • 78.95 (n)
lizard
(Anolis carolinensis)
Reptilia EPB41L3 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia epb41l3 34
  • 73.88 (n)
Str.17099 34
zebrafish
(Danio rerio)
Actinopterygii epb41l3b 34 35
  • 63.38 (n)
CABZ01090303.1 35
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta cora 36 35
  • 60 (a)
CG5022 36
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea frm-3 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 60 (a)
OneToMany
Species where no ortholog for EPB41L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EPB41L3 Gene

ENSEMBL:
Gene Tree for EPB41L3 (if available)
TreeFam:
Gene Tree for EPB41L3 (if available)

Paralogs for EPB41L3 Gene

Variants for EPB41L3 Gene

Sequence variations from dbSNP and Humsavar for EPB41L3 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs10163848 -- 5,593,930(+) ctgaa(C/T)attgc intron-variant
rs10163849 -- 5,593,941(+) tgtta(C/T)cctgt intron-variant
rs10164100 -- 5,593,883(+) cgccc(A/G)gctca intron-variant
rs10164101 -- 5,593,920(+) ctctt(A/G)ttccc intron-variant
rs10164205 -- 5,594,268(+) cagcc(A/G)gtccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPB41L3 Gene

Variant ID Type Subtype PubMed ID
nsv952407 CNV deletion 24416366
nsv576393 CNV gain 21841781
nsv521827 CNV loss 19592680
nsv472411 CNV novel sequence insertion 20440878
esv998712 CNV deletion 20482838
esv989108 CNV deletion 20482838
esv3554993 CNV deletion 23714750
esv3439162 CNV insertion 20981092
esv3439 CNV loss 18987735
esv3363246 CNV insertion 20981092
esv3353097 CNV insertion 20981092
esv3309085 CNV mobile element insertion 20981092
esv3211634 CNV deletion 24192839
esv3140456 CNV deletion 24192839
esv2716719 CNV deletion 23290073
esv2716717 CNV deletion 23290073
esv2716716 CNV deletion 23290073
esv2716715 CNV deletion 23290073
esv2671954 CNV deletion 23128226
esv2666529 CNV deletion 23128226
dgv970e212 CNV loss 25503493
dgv969e212 CNV loss 25503493
dgv53n6 CNV deletion 16902084
dgv184n21 CNV gain 19592680
dgv1543n106 CNV deletion 24896259

Variation tolerance for EPB41L3 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.49; 71.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPB41L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EPB41L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPB41L3 Gene

Disorders for EPB41L3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for EPB41L3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bejel
  • njovera
lung cancer
  • lung cancer, protection against
meningioma, familial
  • meningioma
neurofibromatosis, type 2
  • neurofibromatosis, type ii
clear cell ependymoma
  • cellular ependymoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for EPB41L3

Genetic Association Database (GAD)
EPB41L3
Human Genome Epidemiology (HuGE) Navigator
EPB41L3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EPB41L3
genes like me logo Genes that share disorders with EPB41L3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EPB41L3 Gene

Publications for EPB41L3 Gene

  1. A novel member of the NF2/ERM/4.1 superfamily with growth suppressing properties in lung cancer. (PMID: 9892180) Tran Y.K. … Newsham I.F. (Cancer Res. 1999) 2 3 4 22 64
  2. The tumor suppressor DAL-1/4.1B and protein methylation cooperate in inducing apoptosis in MCF-7 breast cancer cells. (PMID: 16420693) Jiang W. … Newsham I.F. (Mol. Cancer 2006) 3 4 22 64
  3. DAL-1/4.1B tumor suppressor interacts with protein arginine N- methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo. (PMID: 15334060) Singh V. … Newsham I.F. (Oncogene 2004) 3 4 22 64
  4. Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer. (PMID: 12234973) Yageta M. … Murakami Y. (Cancer Res. 2002) 3 4 22 64
  5. Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL- 1/4.1B). (PMID: 21131357) Busam R.D. … Hallberg B.M. (J. Biol. Chem. 2011) 3 4 64

Products for EPB41L3 Gene

Sources for EPB41L3 Gene

Content
Loading form....