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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EPB41L2 Gene

protein-coding   GIFtS: 62
GCID: GC06M131202

Erythrocyte Membrane Protein Band 4.1-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Erythrocyte Membrane Protein Band 4.1-Like 21 2
Generally Expressed Protein 4.12 3
4.1G2 3
4.1-G2
Band 4.1-Like Protein 22
Erythrocyte Membrane Protein Band 4.1 Like-Protein 22

External Ids:    HGNC: 33791   Entrez Gene: 20372   Ensembl: ENSG000000798197   OMIM: 6032375   UniProtKB: O434913   

Export aliases for EPB41L2 gene to outside databases

Previous GC identifers: GC06M130820 GC06M131007 GC06M131141 GC06M128741


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for EPB41L2 Gene: 
EPB41L2 (erythrocyte membrane protein band 4.1-like 2) is a protein-coding gene. Diseases associated with EPB41L2 include malignant ependymoma, and ependymoma. GO annotations related to this gene include actin binding and PH domain binding. An important paralog of this gene is EPB41L5.

Gene Wiki entry for EPB41L2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EPB41L2 gene promoter:
         N-Myc   Sox5   POU2F1   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPB41L2 promoter sequence
   Search SABiosciences Chromatin IP Primers for EPB41L2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPB41L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23

EPB41L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPB41L2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M131202:  view genomic region     (about GC identifiers)

Start:
131,160,487 bp from pter      End:
131,384,462 bp from pter
Size:
223,976 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: E41L2_HUMAN, O43491 (See protein sequence)
Recommended Name: Band 4.1-like protein 2  
Size: 1005 amino acids; 112588 Da
Subunit: Interacts with FCGR1A. Interacts with TRPC4. The CTD domain interacts with FKBP2 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Cell membrane
Secondary accessions: B4DHI8 E9PPD9 Q5T4F0 Q68DV2
Alternative splicing: 4 isoforms:  O43491-1   O43491-2   O43491-3   O43491-4   (No experimental confirmation available. Gene prediction based on cDNA data)

Explore the universe of human proteins at neXtProt for EPB41L2: NX_O43491

Explore proteomics data for EPB41L2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43491

  • EPB41L2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EPB41L2 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001129026.1  NP_001129027.1  NP_001186317.1  NP_001186318.1  NP_001239589.1  NP_001422.1  

    ENSEMBL proteins: 
     ENSP00000434596   ENSP00000434308   ENSP00000434576   ENSP00000402041   ENSP00000338481  
     ENSP00000436349   ENSP00000376222   ENSP00000357110   ENSP00000436348   ENSP00000437207  
     ENSP00000432803   ENSP00000431988   ENSP00000431647   ENSP00000436641   ENSP00000432949  
     ENSP00000437295   ENSP00000397580   ENSP00000434998   ENSP00000436871   ENSP00000432013  
     ENSP00000432329   ENSP00000436145   ENSP00000435556  

    Human Recombinant Protein Products for EPB41L2: 
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    Cloud-Clone Corp. Proteins for EPB41L2 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005856cytoskeleton ----
    GO:0005886plasma membrane IDA--

    EPB41L2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/14 InterPro protein domains (see all 14):
     IPR019748 FERM_central
     IPR018980 FERM_PH-like_C
     IPR019750 Band_41_fam
     IPR000798 Ez/rad/moesin_like
     IPR019749 Band_41_domain

    Graphical View of Domain Structure for InterPro Entry O43491

    ProtoNet protein and cluster: O43491

    2 Blocks protein domains:
    IPB000299 Band 4.1 domain
    IPB007477 SAB


    UniProtKB/Swiss-Prot: E41L2_HUMAN, O43491
    Similarity: Contains 1 FERM domain


    EPB41L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for EPB41L2:
    erythrocyte surface protein 4.1-like 2,113kDa,widely expressed,ezrin/moesin/radixin-like (ERM) family
    member,responding and participating in reorganization of membrane-cytoplasmic interaction,binding F-actin to
    spectrin domain

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005198structural molecule activity IEA--
    GO:0008092cytoskeletal protein binding ----
    GO:0030507spectrin binding IEA--
    GO:0042731PH domain binding IEA--
         
    EPB41L2 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Epb4.1l2):
     endocrine/exocrine gland  nervous system  no phenotypic analysis  normal  reproductive system 

    EPB41L2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for EPB41L2: Epb4.1l2Epb4.tm1.1Aliv Epb4.1l2Epb4.tm1Note

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EPB41L2 
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    SwitchGear 3'UTR luciferase reporter plasmidEPB41L2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EPB41L2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Tight junction
    Tight junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for EPB41L2):
        Tight junction


    EPB41L2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EPB41L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/30 Interacting proteins for EPB41L2 (O434912, 3 ENSP000003384814) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619813, ENSP000003063304I2D: score=3 STRING: ENSP00000306330
    ACTA1P681333, ENSP000003556454I2D: score=2 STRING: ENSP00000355645
    ADORA1P305423, ENSP000003085494I2D: score=1 STRING: ENSP00000308549
    COPS5Q929053, ENSP000003505124I2D: score=1 STRING: ENSP00000350512
    YWHABP319463, ENSP000003001614I2D: score=1 STRING: ENSP00000300161
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030866cortical actin cytoskeleton organization IEA--

    EPB41L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EPB41L2 (E41L2)

    Search CenterWatch for drugs/clinical trials and news about EPB41L2 / E41L2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EPB41L2 gene (6 alternative transcripts): 
    NM_001135554.1  NM_001135555.3  NM_001199388.2  NM_001199389.1  NM_001252660.1  NM_001431.3  

    Unigene Cluster for EPB41L2:

    Erythrocyte membrane protein band 4.1-like 2
    Hs.486470  [show with all ESTs]
    Unigene Representative Sequence: NM_001431
    18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000452150(uc003qcd.1) ENST00000531410 ENST00000528282(uc003qcg.1)
    ENST00000530481(uc010kfl.2) ENST00000445890 ENST00000337057(uc003qch.2 uc010kfk.2)
    ENST00000530757(uc003qce.1 uc003qcf.1) ENST00000392427 ENST00000368128(uc003qci.3 uc011eby.2)
    ENST00000527411 ENST00000524581 ENST00000525271 ENST00000526782 ENST00000368126
    ENST00000525193 ENST00000527659 ENST00000529208 ENST00000527017
    miRNA
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    hsa-miR-22 hsa-miR-140-5p hsa-miR-495 hsa-miR-548p hsa-miR-3673 hsa-miR-1284 hsa-miR-374c hsa-miR-499-5p
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB209522.1 AF027299.1 AF054999.1 AJ251209.1 AK021859.1 AK127088.1 AK295124.1 AK295958.1 
    AK307764.1 AL050384.1 AY047584.1 AY512660.1 BC034718.1 CR749262.1 CR936793.1 

    24/33 DOTS entries (see all 33):

    DT.75184350  DT.100825867  DT.95240584  DT.102835778  DT.99929392  DT.95240595  DT.92461672  DT.100825864 
    DT.95177114  DT.92461678  DT.97788105  DT.92461660  DT.309297  DT.95161928  DT.121367603  DT.97765797 
    DT.100825868  DT.121367588  DT.86841562  DT.100825865  DT.121367547  DT.121367549  DT.121367567  DT.121367573 

    24/396 AceView cDNA sequences (see all 396):

    AI289784 BM479764 BP870468 AL119682 AA889026 AY047584 CA426572 AJ251209 
    AI359520 BU162006 BX955447 AA026543 CA439253 CD245727 W58637 BF511685 
    AK127088 BM703801 BC034718 W73695 AA584416 BQ881858 AI347426 AA428071 

    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for EPB41L2 (see all 21)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^
    SP1:                    -     -     -     -     -     -     -     -     -                                                                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                          -     -     -     -     -     -     -     -                                       
    SP5:                                                                                                                                                            

    ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33a · 33b · 33c
    SP1:                          -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                       
    SP2:                                      -           -     -           -     -     -     -     -           -     -                                       
    SP3:                                                                                      -     -           -                                             
    SP4:                                                                                                                                                      
    SP5:                                                                                            -           -                                             


    ECgene alternative splicing isoforms for EPB41L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EPB41L2 expression in normal human tissues (normalized intensities)      EPB41L2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAACTTAC
    EPB41L2 Expression
    About this image


    EPB41L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Rib
             skeleton/cranium/viscerocranium   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             visceral organ/metanephros/calyx   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ/metanephros/calyx   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Olfactory Bulb   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium/viscerocranium   

    See EPB41L2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EPB41L2

    SOURCE GeneReport for Unigene cluster: Hs.486470

    UniProtKB/Swiss-Prot: E41L2_HUMAN, O43491
    Tissue specificity: Widely expressed

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPB41L2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for EPB41L2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Epb4.1l21 , 5 erythrocyte protein band 4.1-like 21, 5 86.17(n)1
    84.28(a)1
      10 (12.26 cM)5
    138221  NM_001199265.11  NP_001186194.11 
     253597985 
    chicken
    (Gallus gallus)
    Aves EPB41L21 erythrocyte membrane protein band 4.1-like 2 73.55(n)
    72.75(a)
      421703  XM_001232112.2  XP_001232113.2 
    lizard
    (Anolis carolinensis)
    Reptilia EPB41L26
    erythrocyte membrane protein band 4.1-like 2
    64(a)
    1 ↔ 1
    GL343315.1(34236-186256)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL879874.12   -- 76.01(n)    AL879874.1 
    zebrafish
    (Danio rerio)
    Actinopterygii epb41l21 erythrocyte membrane protein band 4.1-like 2 63.33(n)
    64.94(a)
      100329282  XM_002665637.3  XP_002665683.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta cora3 cytoskeleton organization and
    biogenesis cytoskeletal more
    58(a)
    (best of 2)
      56C4   --
    worm
    (Caenorhabditis elegans)
    Secernentea frm-16
    Protein FRM-1, isoform e
    5(a)
    1 → many
    I(14875784-14900330)


    ENSEMBL Gene Tree for EPB41L2 (if available)
    TreeFam Gene Tree for EPB41L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EPB41L2 gene
    EPB41L52  EPB412  FRMD32  EPB41L12  PTPN32  EPB41L4B2  FARP12  PTPN42  
    FRMD52  EPB41L32  FRMD72  EPB41L4A2  FARP22  
    16 SIMAP similar genes for EPB41L2 using alignment to 18 protein entries:     E41L2_HUMAN (see all proteins):
    DKFZp564J1082    EPB41L1    PTPN4    EPB41L3    EPB41    FARP1
    EPB41L5    FARP2    FRMD5    EPB41L4A    EPB41L4B    FRMD3
    RDX    PTPN21    MSN    PTPN14

    EPB41L2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4625 SNPs in EPB41L2 are shown (see all 4625)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1443422631,2
    Cuntested1131206367(+) GCCAGA/GAAAAT 12 P S mis10--------
    rs591184851,2
    C--128795140(+) TTTTT-/T/TA  
            
    ATCAT
    6 -- int10--------
    rs105615591,2
    C--128869201(+) CACAC-/AT/TA 
            
    ACACA
    6 -- int10--------
    rs1895481981,2
    --128875157(+) GAAATA/TACTAA 1 -- us2k10--------
    rs572931321,2
    C--128875634(+) AAAAA-/A/AA  
            
    CAGCC
    5 -- int11NA 2
    rs1507886551,2
    C--131160056(+) AGAAA-/GCATCC 6 -- int1 ds50010--------
    rs1905167581,2
    --131160237(+) TCCCTC/TGGAGA 6 -- int1 ds50010--------
    rs1412997821,2
    --131160287(+) GGAATA/CTGGCA 6 -- int1 ds50010--------
    rs1469899561,2
    --131160436(+) GAAAAA/GTATCA 6 -- int1 ds50010--------
    rs170596711,2
    F--131160532(-) ATTTTG/TCTTCC 6 -- ut31 ese31Minor allele frequency- T:0.08MN 184

    HapMap Linkage Disequilibrium report for EPB41L2 (131160487 - 131384462 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for EPB41L2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2666689CNV Deletion23128226
    esv267684CNV Insertion20981092
    nsv5477CNV Insertion18451855
    esv270827CNV Insertion20981092
    esv273885CNV Insertion20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603237    OMIM disorders: --

    4 diseases for EPB41L2:    About MalaCards
    malignant ependymoma    ependymoma    endotheliitis    leukemia

    1 disease from the University of Copenhagen DISEASES database for EPB41L2:
    Malignant ependymoma

    EPB41L2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): EPB41L2
    Human Genome Epidemiology (HuGE) Navigator: EPB41L2 (4 documents)

    Export disorders for EPB41L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EPB41L2 gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with EPB41L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of 4.1G (EPB41L2), a new member of the skeletal protein 4.1 (EPB41) gene family. (PubMed id 9598318)1, 2, 3, 9 Parra M....Conboy J.G. (1998)
    2. Genetic determinants of statin-induced low-density lip oprotein cholesterol reduction: the Justification for the Use of Statins in Prev ention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. (PubMed id 22331829)1, 4 Chasman D.I....Ridker P.M. (2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Protein 4.1G binds to a unique motif within the FcgammaRI cytoplasmic tail. (PubMed id 18023480)1, 2 Beekman J.M.... Leusen J.H.W. (2008)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    6. Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human. (PubMed id 9828140)1, 3 Peters L.L....Conboy J.G. (1998)
    7. Loci associated with N-glycosylation of human immunogl obulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (2013)
    8. Suppression of adenylyl cyclase-mediated cAMP producti on by plasma membrane associated cytoskeletal protein 4.1G. (PubMed id 23201780)1 Goto T....Nakahata N. (2013)
    9. Serine phosphorylation of FcgRI cytoplasmic domain dir ects lipid raft localization and interaction with protein 4.1G. (PubMed id 22003208)1 Gibson A.W....Kimberly R.P. (2012)
    10. Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. (PubMed id 22361696)2 Stadler C.... Lundberg E. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2037 HGNC: 3379 AceView: EPB41L2 Ensembl:ENSG00000079819 euGenes: HUgn2037
    ECgene: EPB41L2 Kegg: 2037 H-InvDB: EPB41L2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EPB41L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EPB41L2 gene:
    Search GeneIP for patents involving EPB41L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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