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EPB41 Gene

protein-coding GIFtS: 63

GC01P029034

erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: EL1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
4.1R ^¹, ², ³
E41P ^³
EL1 ^², ⁵
EPB4.1 ^³
HE ^²
OTTHUMP00000003772 ^²
OTTHUMP00000003773 ^²
OTTHUMP00000003774 ^²
P4.1 ^³

Descriptions
Band 4.1 ^³
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) ^²
erythrocyte surface protein band 4.1 ^²

External Ids
HGNC: 3377¹
Entrez Gene: 2035²
UniProtKB: P11171³
Ensembl: ENSG00000159023⁷

Search outside databases for aliases for EPB41 gene

Previous GC identifers: GC01P029320 GC01P028379 GC01P028718 GC01P029002 GC01P029003

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EPB41:

Elliptocytosis is a hematologic disorder characterized by elliptically shaped erythrocytes and a

variable degree of hemolytic anemia. Inherited as an autosomal dominant, elliptocytosis results

from mutation in any one of several genes encoding proteins of the red cell membrane skeleton. The

form discussed here is the one found in the 1950s to be linked to Rh blood group and more recently

shown to be caused by a defect in protein 4.1. 'Rh-unlinked' forms of elliptocytosis are

caused by mutation in the alpha-spectrin gene (MIM 182860), the beta-spectrin gene (MIM 182870),

or the band 3 gene (MIM 109270).[supplied by OMIM]

UniProtKB/Swiss-Prot: 41_HUMAN, P11171

Function: Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays

a key role in regulating membrane physical properties of mechanical stability and deformability by

stabilizing spectrin-actin interaction. Recruits DLG1 to membranes

Gene Wiki entry for EPB41 (Band_4.1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EPB41 gene

Entrez Gene cytogenetic band: 1p33-p32 Ensembl cytogenetic band: 1p35.3 HGNC cytogenetic band: 1p33-p32

EPB41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P029034: (about GC identifiers)

Start:	29,086,215 bp from pter
End:	29,319,545 bp from pter
Size:	233,331 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004610.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: 41_HUMAN, P11171 (See protein sequence)

Recommended Name: Protein 4.1

Size: 864 amino acids; 97017 Da

Subunit: Binds with a high affinity to glycophorin and with lower affinity to band III protein.

Associates with the nuclear mitotic apparatus. Binds calmodulin, CENPJ and DLG1. Also found to

associate with contractile apparatus and tight junctions

Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Nucleus

PDB structure from and Proteopedia :

1GG3 (3D)

2RQ1 (3D)

Secondary accessions: B1ALH8 P11176 Q14245 Q5TB35 Q5VXN8 Q8IXV9 Q9Y578 Q9Y579

Alternative splicing: 7 isoforms: P11171-1 P11171-2 P11171-3 P11171-4 P11171-5 P11171-6 P11171-7

Post-translational modifications:

Phosphorylated at multiple sites by different protein kinases and each phosphorylation event

selectively modulates the protein's functions¹

Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the

spectrin/actin/4.1 ternary complex¹

O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_004428.1 NP_976217.1 NP_976218.1

ENSEMBL proteins:

ENSP00000351880 ENSP00000345259 ENSP00000362904 ENSP00000362903 ENSP00000362906 ENSP00000381828

ENSP00000317597 ENSP00000381841 ENSP00000348397 ENSP00000290100 ENSP00000381839 ENSP00000381837

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (EPB41)
	Human Recombinant Proteins from Abnova (EPB41)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/8 Gene Ontology (GO) cellular component terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	TAS	9598318
GO:0008091	spectrin	TAS	6894932
GO:0014731	spectrin-associated cytoskeleton	TAS	3693401

About this table

Antibodies for EPB41:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for EPB41
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (EPB41), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EPB41)
	Novus Biologicals Antibodies for EPB41

Assays for EPB41:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P11171

ProtoNet protein and cluster: P11171

2 Blocks protein families:

IPB000299 Band 4.1 domain

IPB007477 SAB

UniProtKB/Swiss-Prot: 41_HUMAN, P11171

Similarity: Contains 1 FERM domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EPB41)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EPB41)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): BC039079

Applied Biosystems Silencer® siRNAs for EPB41

Sigma-Aldrich siRNA and siRNA Panels for EPB41

Sigma-Aldrich shRNA Panels and shRNA for EPB41

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EPB41
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_004437
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_004437
untagged cDNA clones in CMV expression vector (see all 6): BC039079

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_203343

UniProtKB/Swiss-Prot: 41_HUMAN, P11171

Function: Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays

a key role in regulating membrane physical properties of mechanical stability and deformability by

stabilizing spectrin-actin interaction. Recruits DLG1 to membranes

Genatlas biochemistry entry for EPB41:

erythrocyte surface protein,band 4.1,80kDa,with a complex tissue-specific and developmentally

regulated erythroid and non erythroid expression pattern resulting from extensive alternative pre

m-RNA splicing,two possible initiation sites and post translational modification,located in

cytoplasm and/or nucleus in non erythroid cells,binding F-actin to spectrin dimers and crucial for

the maintenance of integral membrane red blood cell shape,ezrin/moesin/radixin-like (ERM) family

member, responding and participating in reorganization of membrane-cytoplasmic interactions

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Epb4.1):

hematopoietic system

homeostasis/metabolism

immune system

liver/biliary system

renal/urinary system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005200	structural constituent of cytoskeleton	TAS	6894932
GO:0005545	phosphatidylinositol binding	IDA	16669616
GO:0030507	spectrin binding	TAS	3693401

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for EPB41 (Your Favorite Gene powered by Ingenuity)

Tight Junction Signaling

GeneDecks EPB41 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for EPB41

5/65 Interacting proteins for EPB41 (ENSP00000345259³ P11171^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 65 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CASK	O14936¹^,²	STRING (score=.999) EBI-1050906, EBI-1215506 MINT-17057 EBI-1050906, EBI-1215506 MINT-17057
CACYBP	Q9HB71¹	EBI-1050906, EBI-1047302
CALR	P27797¹	EBI-1050906, EBI-1049597
CDK2	P24941¹	EBI-1050906, EBI-375096
ECHS1	P30084¹	EBI-1050906, EBI-719602

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008015	blood circulation	TAS	6894932
GO:0030866	cortical actin cytoskeleton organization	IEA	--
GO:0032092	positive regulation of protein binding	IDA	3693401

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EPB41
1 Novoseek chemical compound relationship for EPB41 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	0.00	5	11224681 (1), 11017195 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EPB41)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EPB41)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): BC039079

Sigma-Aldrich siRNA and siRNA Panels for EPB41

Sigma-Aldrich shRNA Panels and shRNA for EPB41

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004437 NM_203342 NM_203343

REFSEQ mRNAs for EPB41 gene (3 alternative transcripts):

NM_004437.2 NM_203342.1 NM_203343.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004437 NM_203342 NM_203343

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_004437
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_004437
                                 untagged cDNA clones in CMV expression vector (see all 6): BC039079

Additional cDNA sequence:

AB209649.1 AF156225.1 AK172796.1 AK299093.1 AK299736.1 AK307816.1 AK310655.1 BC009063.1

BC039079.1 BC081539.1 BC096104.1 BC096105.1 BC113841.1 BC114450.1 CR601097.1 CR622465.1

J03796.1 M14993.1 M61733.1

17 DOTS entries:

DT.100827927 DT.444098 DT.99939612 DT.91996271 DT.100718032 DT.100827925 DT.100827922 DT.100827924

DT.100827930 DT.121442050 DT.101983016 DT.121441960 DT.92420651 DT.121441976 DT.92420646 DT.95069023

DT.92420649

24/370 AceView cDNA sequences (see all 370 ):

BM454463 BU159552 BC009063 BU164992 BU663983 BG943340 BC039079 BM704269

AI241891 BF476313 CR622465 BM465039 J03796 AL520065 AI638770 BX952914

BP364691 AI400417 CR601097 CF136825 BQ424914 AI656046 CB158940 AA342636

highest scoring ESTs for EPB41:

J03796 M61733 AA459496 AL520065 AW968474 BE257308 BF901970 BG249428 BG764441 BM452936

Unigene Cluster for EPB41:

Erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)

Hs.175437 [show with all ESTs]

Unigene Representative Sequence: NM_203342

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for EPB41 (see all 12 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	·	4d	·	4e	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19a	·	19b	·
SP1:																			-
SP2:																																													-
SP3:																			-																								-		-
SP4:																																											-		-
SP5:					-		-												-						-																		-		-		-

ExUns:	19c	^	20	^	21a	·	21b	^	22	^	23a	·	23b	^	24	^	25	^	26	^	27a	·	27b
SP1:	-		-		-		-		-
SP2:	-		-		-		-		-
SP3:	-		-		-		-		-
SP4:	-		-		-		-		-						-
SP5:	-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for EPB41

12 Ensembl transcripts including schematic representations:

ENST00000358989 ENST00000343067 ENST00000373798 ENST00000373797 ENST00000373800 ENST00000398850

ENST00000349460 ENST00000398865 ENST00000356093 ENST00000347529 ENST00000398863 ENST00000398861

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EPB41 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EPB41

¹ / ² / ³

11 probe-sets matching EPB41 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
55437_at²^{, 3}	U95-C	1	1.00	1.00	0.77	1.16	AI819579	0.80	0.70	0.75	1
34581_s_at²^{, 3}	U95-A	1	1.00	1.00	0.87	0.12	M61733	1.00	0.80	0.91	1
32343_at²^{, 3}	U95-A	2	1.00	0.97	0.75	0.46	J03796	1.00	0.80	0.91	1
49307_s_at²^{, 3}	U95-C	2	1.00	0.97	0.92	1.39	AA522435	0.80	0.70	0.75	1
207793_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004437	0.60	0.83	0.73	1
225051_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA522435	0.80	0.70	0.75	1
214530_x_at²^{, 3}	U133-A	3	0.73	0.88	--	--	AF156225	0.60	0.83	0.73	1
207793_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225051_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554481_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214530_x_at²	U133Plus2	3	0.73	0.88	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGGCTTGGAG

SOURCE GeneReport for Unigene cluster: Hs.175437
Expression variation in blood from EXPOLDB for EPB41

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EPB41 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EPB41¹	--	erythrocyte membrane protein band 4.1 (elliptocytosis more	91.6(n) 93.67(a)	442955 NM_001003362.1 NP_001003362.1
chimpanzee (Pan troglodytes)	EPB41¹	--	erythrocyte membrane protein band 4.1 (elliptocytosis more	98.44(n) 97.97(a)	456689 XM_513260.2 XP_513260.2
cow (Bos taurus)	EPB41¹	--	erythrocyte membrane protein band 4.1 (elliptocytosis more	91.86(n) 95.01(a)	281753 NM_174311.1 NP_776736.1
rat (Rattus norvegicus)	Epb4.1¹	--	erythrocyte membrane protein band 4.1	86.58(n) 90.42(a)	313052 XM_232771.4 XP_232771.4
mouse (Mus musculus)	Epb4.1^{1, 5}	4 (65.70 cM)⁵	erythrocyte protein band 4.1^{1, 5}	86.35(n)¹ 89.57(a)¹	269587¹ NM_183428.2¹ NP_906273.2¹ AB370255⁵ AB370256⁵ (see all 40)

About this table Species with no ortholog for EPB41

ENSEMBL Gene Tree for EPB41

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EPB41 gene

EPB41L3² EPB41L2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1002 NCBI SNPs in EPB41 are shown (see all 1002 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 233)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs502393^1,2	A,C,F,H,O	29316262(+)	`GTCCAT/CGGAAT`	3	--	ut3¹ ese³		6		MN EA EU WA	2078
	rs2249138^1,2	A,C,F,H,O	29316310(-)	`TTGGCC/TTCCAA`	3	--	ut3¹		13		EA EU WA NA	2700
	rs12120422^1,2	C,F,H	29317814(+)	`CCAGGT/CGGGAC`	3	--	ut3¹ ese³		8		EU EA WA	824
	rs157223^1,2	A,C,F	29084935(-)	`CCATAG/ATCTAG`	3	--	ng5¹		2		NA	182
	rs569716^1,2	A,C,F	29317131(+)	`TTGGGG/ACTTAG`	3	--	ut3¹		1		MN	93
	rs149934^1,2	A,C,H	29084753(-)	`ACACAC/TGTGCG`	3	--	ng5¹ tfbs³		4		EU EA WA	418
	rs157224^1,2	C,F,H	29085921(-)	`GACACG/TTGGTA`	3	--	ng5¹ tfbs³		4		EU EA WA	418
	rs554820^1,2	F	29317990(-)	`AGGCAG/CTGGGC`	3	--	ut3¹ ese³		1		MN	184
	rs157222^1,2	A	29084866(-)	`GGGCTC/TCAAGG`	3	--	ng5¹		0	--	--	--	--
--	rs157221^1,2	C	29084518(-)	`AAATGA/GGAGTA`	3	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for EPB41 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 130500 disorders: 611804

UniProtKB/Swiss-Prot: 41_HUMAN, P11171

Defects in EPB41 are the cause of elliptocytosis type 1 (EL1) [MIM:611804]. EL1 is a

Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant,

hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red

cell shape

Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:266140]. HPP is

an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis,

poikilocytosis, and an unusual thermal sensitivity of red cells

2 Novoseek disease relationships for EPB41 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
elliptocytosis hereditary	85.20	2	12432217 (1), 15071791 (1)
tumors	5.57	2	16157202 (2)

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Human Gene Mutation Database: EPB41

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/105 PubMed articles for EPB41 gene (see all 105 ):

An alternative domain containing a leucine-rich sequence regulates nuclear cytoplasmic localization of protein 4.1R. (PubMed id 12427749)^{1, 3, 4} Luque C.M.... Correas I. (2003)
Protein 4.1R core domain structure and insights into regulation of cytoskeletal organization. (PubMed id 11017195)^{1, 3, 4} Han B.-G.... Jap B.K. (2000)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Mitotic regulation of protein 4.1R involves phosphorylation by cdc2 kinase. (PubMed id 15525677)^{3, 4} Huang S.-C.... Benz E.J. Jr. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Properties of the C-terminal domain of 4.1 proteins. (PubMed id 11432737)^{3, 4} Scott C.... Baines A.J. (2001)
Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex. (PubMed id 11003675)^{3, 4} Hung L.-Y.... Tang T.K. (2000)
Ca(2+)-dependent and Ca(2+)-independent calmodulin binding sites in erythrocyte protein 4.1. Implications for regulation of protein 4.1 interactions with transmembrane proteins. (PubMed id 10692436)^{3, 4} Nunomura W.... Mohandas N. (2000)
Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. (PubMed id 7937897)^{3, 4} Lue R.A.... Chishti A.H. (1994)
Phosphorylation of protein 4.1 on tyrosine-418 modulates its function in vitro. (PubMed id 1647028)^{3, 4} Subrahmanyan G.... Anderson R.A. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2035	HGNC: 3377	AceView: EPB41	Ensembl:ENSG00000159023	euGenes: HUgn2035
ECgene: EPB41	H-InvDB: EPB41

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for EPB41
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for EPB41:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EPB41-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EPB41		Antibodies for EPB41
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for EPB41		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (EPB41)
	Antibodies (EPB41)
	Chimera RNAi (EPB41)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (EPB41)
	Antibodies (EPB41)

Search OriGene for EPB41

Search Tocris compounds for EPB41

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for EPB41

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
EPB41 Gene at Home site.
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EPB41 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for EPB41

Summaries
for EPB41

Genomic Location
for EPB41

Proteins
for EPB41

Protein Domains/
Families
for EPB41

Gene Function
for EPB41

Pathways & Interactions
for EPB41

Drugs & Compounds
for EPB41

Transcripts
for EPB41

Expression
for EPB41

Orthologs
for EPB41

Paralogs
for EPB41

SNPs/Variants
for EPB41

Disorders & Mutations
for EPB41

Medical News
for EPB41

Publications
for EPB41

Search for EPB41

Genome Databases showing EPB41

Other Databases showing EPB41

Specialized Databases showing EPB41

Licensable Technologies
for EPB41

Services
for EPB41

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EPB41 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor EPB41

Summariesfor EPB41

Genomic Locationfor EPB41

Proteinsfor EPB41

Protein Domains/Familiesfor EPB41

Gene Functionfor EPB41

Pathways & Interactionsfor EPB41

Drugs & Compoundsfor EPB41

Transcriptsfor EPB41

Expression for EPB41

Orthologsfor EPB41

Paralogsfor EPB41

SNPs/Variantsfor EPB41

Disorders & Mutationsfor EPB41

Medical Newsfor EPB41

Publicationsfor EPB41

Search for EPB41

Genome Databases showing EPB41

Other Databases showing EPB41

Specialized Databases showing EPB41

Licensable Technologiesfor EPB41

Servicesfor EPB41

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EPB41

Summaries
for EPB41

Genomic Location
for EPB41

Proteins
for EPB41

Protein Domains/
Families
for EPB41

Gene Function
for EPB41

Pathways & Interactions
for EPB41

Drugs & Compounds
for EPB41

Transcripts
for EPB41

Expression
for EPB41

Orthologs
for EPB41

Paralogs
for EPB41

SNPs/Variants
for EPB41

Disorders & Mutations
for EPB41

Medical News
for EPB41

Publications
for EPB41

Licensable Technologies
for EPB41

Services
for EPB41