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Aliases for EP400NL Gene

Aliases for EP400NL Gene

  • EP400 N-Terminal Like 2 3 5

External Ids for EP400NL Gene

Previous GeneCards Identifiers for EP400NL Gene

  • GC12P131141
  • GC12P132568
  • GC12P129454

Summaries for EP400NL Gene

GeneCards Summary for EP400NL Gene

EP400NL (EP400 N-Terminal Like) is a Pseudogene. An important paralog of this gene is EP400.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EP400NL Gene

Genomics for EP400NL Gene

Regulatory Elements for EP400NL Gene

Enhancers for EP400NL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F132487 1.8 FANTOM5 Ensembl ENCODE 40.9 +415.1 415067 23.9 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF26 EP400NL ZNF891 FBRSL1 EP400 ZNF10 GOLGA3 NOC4L ENSG00000256875 ZNF84
GH12F132083 1.1 ENCODE 58.4 +0.4 394 2.2 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 FOS SP3 SP5 EP400NL DDX51 ENSG00000279640
GH12F132095 0.6 ENCODE 34.4 +11.6 11648 0.2 ELF3 CBX3 RARA ARID1B E2F1 GATA3 FOS ZBTB33 TRIM24 EP400NL SNORA49 ENSG00000279640
GH12F132426 1.6 FANTOM5 Ensembl ENCODE 11.7 +346.1 346063 8.1 MLX ZFP64 ARID4B ZNF48 SLC30A9 GLIS2 CBX5 ZNF143 KLF13 SP5 ZNF140 SFSWAP EP400NL EP400 GOLGA3 ZNF10 FBRSL1 LRCOL1 ZNF84 PIR54346
GH12F131782 1.2 Ensembl ENCODE 15.4 -299.7 -299650 4.0 TBP HDAC1 ATF1 CBX3 PKNOX1 TBL1XR1 CREB3L1 INSM2 SIN3A ZBTB40 MMP17 SFSWAP EP400 EP400NL RNU6-1017P ADGRD1 DDX51 NOC4L GC12M131802 RNA5SP378
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EP400NL on UCSC Golden Path with GeneCards custom track

Promoters for EP400NL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001468525 417 1801 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 SP3 SP5 NFYC

Genomic Location for EP400NL Gene

Chromosome:
12
Start:
132,084,283 bp from pter
End:
132,131,639 bp from pter
Size:
47,357 bases
Orientation:
Plus strand

Genomic View for EP400NL Gene

Genes around EP400NL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EP400NL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EP400NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EP400NL Gene

Proteins for EP400NL Gene

  • Protein details for EP400NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZTU2-E400N_HUMAN
    Recommended name:
    EP400 N-terminal-like protein
    Protein Accession:
    Q6ZTU2
    Secondary Accessions:
    • A6NLB7
    • A8K0Z5
    • B3KQY2
    • Q6NXP1
    • Q8N253
    • Q8N7S7
    • Q9UFJ3

    Protein attributes for EP400NL Gene

    Size:
    488 amino acids
    Molecular mass:
    51753 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB56026.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for EP400NL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EP400NL Gene

Post-translational modifications for EP400NL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EP400NL Gene

Domains & Families for EP400NL Gene

Protein Domains for EP400NL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EP400NL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EP400NL: view

No data available for Gene Families and UniProtKB/Swiss-Prot for EP400NL Gene

Function for EP400NL Gene

Phenotypes for EP400NL Gene

genes like me logo Genes that share phenotypes with EP400NL: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EP400NL Gene

Localization for EP400NL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EP400NL gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for EP400NL Gene

Pathways & Interactions for EP400NL Gene

SuperPathways for EP400NL Gene

No Data Available

Interacting Proteins for EP400NL Gene

Selected Interacting proteins: Q6ZTU2-E400N_HUMAN for EP400NL Gene via IID

Gene Ontology (GO) - Biological Process for EP400NL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EP400NL Gene

Transcripts for EP400NL Gene

Unigene Clusters for EP400NL Gene

EP400 N-terminal like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EP400NL Gene

No ASD Table

Relevant External Links for EP400NL Gene

GeneLoc Exon Structure for
EP400NL
ECgene alternative splicing isoforms for
EP400NL

Expression for EP400NL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EP400NL Gene

mRNA differential expression in normal tissues according to GTEx for EP400NL Gene

This gene is overexpressed in Testis (x4.3).

Protein differential expression in normal tissues from HIPED for EP400NL Gene

This gene is overexpressed in Testis (62.2) and CD4 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EP400NL Gene



Protein tissue co-expression partners for EP400NL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EP400NL Gene:

EP400NL

SOURCE GeneReport for Unigene cluster for EP400NL Gene:

Hs.122115
genes like me logo Genes that share expression patterns with EP400NL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for EP400NL Gene

Orthologs for EP400NL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EP400NL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EP400NL 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 7 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta dom 35
  • 1 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ssl-1 35
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWR1 35
  • 1 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 1 (a)
OneToMany
Species where no ortholog for EP400NL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for EP400NL Gene

ENSEMBL:
Gene Tree for EP400NL (if available)
TreeFam:
Gene Tree for EP400NL (if available)

Paralogs for EP400NL Gene

Paralogs for EP400NL Gene

(1) SIMAP similar genes for EP400NL Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with EP400NL: view

Variants for EP400NL Gene

Sequence variations from dbSNP and Humsavar for EP400NL Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10574229 -- 132,086,034(+) TAAAA(-/ATT)ATTAT intron-variant
rs10794453 -- 132,103,084(+) CCTCC(C/T)GCACT intron-variant
rs10902492 -- 132,102,787(+) TGAAG(C/G)GACAT intron-variant
rs10902493 -- 132,103,111(+) AGTTC(G/T)TAGTA intron-variant
rs10902494 -- 132,103,125(+) AGCAG(A/T)AGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EP400NL Gene

Variant ID Type Subtype PubMed ID
nsv826563 CNV gain 20364138
nsv509493 CNV insertion 20534489
nsv473425 CNV novel sequence insertion 20440878
nsv470333 CNV loss 18288195
nsv428285 CNV gain 18775914
nsv1121492 CNV deletion 24896259
nsv1070570 CNV deletion 25765185
nsv1041402 CNV gain 25217958
esv2746912 CNV deletion 23290073
esv2746911 CNV deletion 23290073
esv2288713 CNV deletion 18987734
dgv103n21 CNV loss 19592680

Variation tolerance for EP400NL Gene

Gene Damage Index Score: 4.62; 65.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EP400NL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EP400NL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EP400NL Gene

Disorders for EP400NL Gene

Relevant External Links for EP400NL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EP400NL

No disorders were found for EP400NL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EP400NL Gene

Publications for EP400NL Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A genome-wide association meta-analysis of plasma AI^ peptides concentrations in the elderly. (PMID: 24535457) Chouraki V. … Lambert J.C. (Mol. Psychiatry 2014) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for EP400NL Gene

Sources for EP400NL Gene

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