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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EP400NL Gene

protein-coding   GIFtS: 33
GCID: GC12P132568

EP400 N-Terminal Like

  Search for EP400NL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
EP400 N-Terminal Like1 2

External Ids:    HGNC: 266021   Entrez Gene: 3479182   Ensembl: ENSG000001856847   UniProtKB: Q6ZTU23   
ORGUL members:         
NONCODE14:n344541 n381970 n346008 n405993      

Export aliases for EP400NL gene to outside databases

Previous GC identifers: GC12P131141 GC12P129454


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for EP400NL Gene: 
EP400NL (EP400 N-terminal like) is a protein-coding gene, and is affiliated with the lncRNA class. An important paralog of this gene is EP400.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EP400NL gene promoter:
         USF1   AML1a   AP-2gamma   RORalpha2   USF-1   AP-2beta   FOXO1a   AP-2alpha   AP-2alphaA   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for EP400NL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EP400NL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

EP400NL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EP400NL gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P132568:  view genomic region     (about GC identifiers)

Start:
132,568,828 bp from pter      End:
132,613,029 bp from pter
Size:
44,202 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for EP400NL

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: E400N_HUMAN, Q6ZTU2 (See protein sequence)
Recommended Name: EP400 N-terminal-like protein  
Size: 488 amino acids; 51753 Da
Sequence caution: Sequence=CAB56026.2; Type=Erroneous initiation;
Secondary accessions: A6NLB7 A8K0Z5 B3KQY2 Q6NXP1 Q8N253 Q8N7S7 Q9UFJ3
Alternative splicing: 5 isoforms:  Q6ZTU2-1   Q6ZTU2-2   Q6ZTU2-4   Q6ZTU2-5   Q6ZTU2-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EP400NL: NX_Q6ZTU2

Explore proteomics data for EP400NL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZTU2

  • EP400NL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EP400NL Protein Expression

    ENSEMBL proteins: 
     ENSP00000396499   ENSP00000402806   ENSP00000374211   ENSP00000404338   ENSP00000376163  
     ENSP00000385626   ENSP00000441814   ENSP00000328997   ENSP00000365812   ENSP00000354409  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6ZTU2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EP400NL

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EP400NL (E400N)

    Search CenterWatch for drugs/clinical trials and news about EP400NL / E400N

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for EP400NL gene: 
    NM_182613.1  

    Unigene Cluster for EP400NL:

    EP400 N-terminal like
    Hs.122115  [show with all ESTs]
    Unigene Representative Sequence: AK128208
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446190(uc001ujr.2) ENST00000537558 ENST00000539351 ENST00000454179
    ENST00000488030 ENST00000389560(uc001ujs.4 uc001ujv.3) ENST00000443539(uc009zyq.3)
    ENST00000392352(uc001ujt.3) ENST00000407361 ENST00000539205 ENST00000332441(uc001ujw.1)
    ENST00000475841(uc001ujx.1) ENST00000376625 ENST00000361109
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EP400NL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EP400NL

    Additional mRNA sequence: 

    AK090610.1 AK091234.1 AK097720.1 AK126212.1 AK128208.1 AK289710.1 AL117637.1 BC015414.1 
    BC066974.1 NR_003290.2 

    17 DOTS entries:

    DT.100008893  DT.312029  DT.435152  DT.99951945  DT.40130280  DT.99934371  DT.92417658  DT.40125004 
    DT.100779428  DT.121186844  DT.100683125  DT.121186833  DT.92416994  DT.95149621  DT.91647796  DT.91723466 
    DT.95317409 

    24/121 AceView cDNA sequences (see all 121):

    AW449785 BX112045 BI826960 BU754256 BQ448701 BQ014472 BQ614231 AK097720 
    AI281315 BU736308 BF223389 BM824005 AL117637 BC015414 BC066974 CB128813 
    CN482598 AX746533 BM709962 BM710701 AI281259 BG149289 AK090610 AI370824 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EP400NL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGCTGTTA
    EP400NL Expression
    About this image


    See EP400NL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EP400NL

    SOURCE GeneReport for Unigene cluster: Hs.122115
        SABiosciences Custom PCR Arrays for EP400NL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EP400NL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for EP400NL gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves EP400NL6
    Uncharacterized protein
    7(a)
    possible ortholog
    15(2568608-2612666)
    lizard
    (Anolis carolinensis)
    Reptilia EP4006
    E1A binding protein p400
    6(a)
    possible ortholog
    GL343364.1(163123-220000)
    zebrafish
    (Danio rerio)
    Actinopterygii EP400NL6
    EP400 N-terminal like
    5(a)
    1 → many
    8(46415549-46469367)
    fruit fly
    (Drosophila melanogaster)
    Insecta dom6
    domino

    1 → many
    2R(17210949-17229352)
    worm
    (Caenorhabditis elegans)
    Secernentea ssl-16
    Helicase ssl-1

    possible ortholog
    III(12714566-12743929)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWR16
    Swi2/Snf2-related ATPase that is the structural co...

    1 → many
    IV(1135932-1140476)
            Species with no ortholog for EP400NL

    ENSEMBL Gene Tree for EP400NL (if available)
    TreeFam Gene Tree for EP400NL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EP400NL gene
    EP4002  SRCAP2  
    1 SIMAP similar gene for EP400NL using alignment to 6 protein entries:     E400N_HUMAN (see all proteins):
    EP400

    EP400NL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/849 SNPs in EP400NL are shown (see all 849)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1408412801,2
    C--132566867(+) GGGACG/TATTGT 1 -- us2k10--------
    rs1501578851,2
    --132566889(+) GCACTA/GCCTCT 1 -- us2k10--------
    rs1119484231,2
    C,F--132566951(+) ATGCGC/TGTCCT 1 -- us2k12Minor allele frequency- T:0.05CSA WA 120
    rs128189961,2
    C,H--132567030(+) CAGTCT/CCActc 1 -- us2k15Minor allele frequency- C:0.00NS EA NA 420
    rs1456319001,2
    --132567032(+) GTCTCA/TCTCAC 1 -- us2k10--------
    rs1891606401,2
    C--132567114(+) ATTCTC/TCTGCC 1 -- us2k10--------
    rs1410720311,2
    C--132567247(+) TGATCC/TGCCCG 1 -- us2k10--------
    rs1469427491,2
    --132567254(+) CCCGCC/GTCGGC 1 -- us2k10--------
    rs1126727481,2
    C,F--132567298(+) CCGCAG/CCCGGC 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs744115471,2
    C,F--132567327(+) ATAAGG/ACCCTA 1 -- us2k11Minor allele frequency- A:0.05EA 120

    HapMap Linkage Disequilibrium report for EP400NL (132568828 - 132613029 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for EP400NL (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746912CNV Deletion23290073
    esv2288713CNV Deletion18987734
    esv2746911CNV Deletion23290073
    nsv509493CNV Insertion20534489
    nsv899720CNV Loss21882294
    dgv1520n71CNV Loss21882294
    dgv1524n71CNV Loss21882294
    dgv1522n71CNV Loss21882294
    dgv1523n71CNV Loss21882294
    dgv1519n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EP400NL gene integrated from 9 sources:
    (articles sorted by number of sources associating them with EP400NL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    5. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 347918 HGNC: 26602 AceView: FLJ33915 Ensembl:ENSG00000185684 euGenes: HUgn347918
    ECgene: EP400NL H-InvDB: EP400NL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EP400NL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EP400NL gene:
    Search GeneIP for patents involving EP400NL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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