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EP400 Gene

protein-coding   GIFtS: 59
GCID: GC12P132434

E1A Binding Protein P400

(Previous name: trinucleotide repeat containing 12)
(Previous symbol: TNRC12)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
E1A Binding Protein P4001 2     P400 KDa SWI2/SNF2-Related Protein2 3
TNRC121 2 3 5     KIAA14983 5
Trinucleotide Repeat Containing 121 2     P4002
Domino Homolog2 3     E1A-Binding Protein P4002
Trinucleotide Repeat-Containing Gene 12 Protein2 3     P400 SWI2/SNF2-Related Protein2
CAGH322 3     EC 3.6.4.-3
CAG Repeat Protein 322 3     KIAA18183
hDomino2 3     EC 3.6.18

External Ids:    HGNC: 119581   Entrez Gene: 576342   Ensembl: ENSG000001834957   OMIM: 6062655   UniProtKB: Q96L913   

Export aliases for EP400 gene to outside databases

Previous GC identifers: GC12U990164 GC12P132315 GC12P130928 GC12P131111 GC12P131000 GC12P129320


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EP400 Gene:
EP400 (E1A binding protein p400) is a protein-coding gene. Diseases associated with EP400 include ossifying fibromyxoid tumor, and brain cancer. GO annotations related to this gene include chromatin binding and helicase activity. An important paralog of this gene is EP400NL.

UniProtKB/Swiss-Prot: EP400_HUMAN, Q96L91
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation
of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter
nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which
positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes
during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part,
contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity.
Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the
nucleosome

Gene Wiki entry for EP400 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the EP400 gene promoter:
         HTF   XBP-1   CUTL1   STAT5A   HNF-4alpha2   Tal-1beta   c-Ets-1   HNF-4alpha1   E47   Pax-3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEP400 promoter sequence
   Search Chromatin IP Primers for EP400

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EP400


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

EP400 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EP400 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P132434:  view genomic region     (about GC identifiers)

Start:
132,434,465 bp from pter      End:
132,565,011 bp from pter
Size:
130,547 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EP400_HUMAN, Q96L91 (See protein sequence)
Recommended Name: E1A-binding protein p400  
Size: 3159 amino acids; 343489 Da
Subunit: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60
and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin,
ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. May also participate in the
formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF
related protein SRCAP. The NuA4 complex interacts with MYC and the adenovirus E1A protein. EP400 interacts with
TRRAP, RUVBL1 and RUVBL2. Component of a SWR1-like complex. Interacts with ZNF42. Interacts with PHF5A (By
similarity)
Sequence caution: Sequence=AAB91441.1; Type=Frameshift; Positions=2959, 3020; Sequence=AAH37208.1;
Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAH64554.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA96022.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened;
Secondary accessions: O15411 Q6P2F5 Q8N8Q7 Q8NE05 Q96JK7 Q9P230
Alternative splicing: 5 isoforms:  Q96L91-1   Q96L91-2   Q96L91-3   Q96L91-4   Q96L91-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EP400: NX_Q96L91

Explore proteomics data for EP400 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1096, Lys1291, Lys1634, Lys2202
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for EP400 (Q96L91)
     GLGKTVQ  NGILADE 


    See EP400 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056224.3  
    ENSEMBL proteins: 
     ENSP00000333602   ENSP00000374212   ENSP00000374213   ENSP00000331737   ENSP00000330620  
    Reactome Protein details: Q96L91

    EP400 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for EP400
    GenScript Custom Purified and Recombinant Proteins Services for EP400
    Novus Biologicals EP400 Protein
    Novus Biologicals EP400 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EP400

    EP400 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for EP400
    Novus Biologicals EP400 Antibodies
    Abcam antibodies for EP400
    Cloud-Clone Corp. Antibodies for EP400
    ThermoFisher Antibodies for EP400
    LSBio Antibodies in human, mouse, rat for EP400

    EP400 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EP400
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EP400
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EP400
    Cloud-Clone Corp. CLIAs for EP400


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR027417 P-loop_NTPase
     IPR013999 HAS_subgr
     IPR014012 Helicase/SANT-assoc_DNA-bd
     IPR017877 Myb-like_dom
     IPR000330 SNF2_N

    Graphical View of Domain Structure for InterPro Entry Q96L91

    ProtoNet protein and cluster: Q96L91

    3 Blocks protein domains:
    IPB000330 SNF2 related domain
    IPB002464 ATP-dependent helicase
    IPB006562 HSA


    UniProtKB/Swiss-Prot: EP400_HUMAN, Q96L91
    Similarity: Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 HSA domain
    Similarity: Contains 1 Myb-like domain


    EP400 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EP400_HUMAN, Q96L91
    Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation
    of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter
    nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which
    positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes
    during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part,
    contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity.
    Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the
    nucleosome

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0004386helicase activity IEA--
    GO:0005515protein binding ----
         
    EP400 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for EP400:
     G0/1 arrest  Increased G1 DNA content  Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ep400):
     embryogenesis  hematopoietic system  mortality/aging  nervous system  no phenotypic analysis 

    EP400 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ep400tm1Fuku for EP400

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EP400
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EP400

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EP400
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EP400

    miRNA
    Products:
        
    miRTarBase miRNAs that target EP400:
    hsa-mir-320a (MIRT044668), hsa-mir-122-5p (MIRT023367), hsa-mir-615-3p (MIRT040435), hsa-let-7i-5p (MIRT046550), hsa-mir-340-3p (MIRT043858)

    Block miRNA regulation of human, mouse, rat EP400 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EP400 (see all 20):
    hsa-miR-3673 hsa-miR-520d-5p hsa-miR-4272 hsa-miR-938 hsa-miR-1297 hsa-miR-105 hsa-miR-548l hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidEP400 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EP400
    Predesigned siRNA for gene silencing in human, mouse, rat EP400

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EP400

    Clone
    Products:
         
    OriGene clones in human, mouse for EP400 (see all 6)
    OriGene ORF clones in mouse, rat for EP400
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EP400 (NM_015409)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EP400
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EP400

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EP400
    Browse ESI BIO Cell Lines and PureStem Progenitors for EP400 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EP400


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EP400_HUMAN, Q96L91: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000812Swr1 complex IDA--
    GO:0005654nucleoplasm TAS--
    GO:0016607nuclear speck ISS--
    GO:0035267NuA4 histone acetyltransferase complex IDA14966270

    EP400 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EP400 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34
    2Cellular Senescence
    Cellular Senescence0.81
    Cellular responses to stress0.81
    3Packaging Of Telomere Ends
    DNA Damage/Telomere Stress Induced Senescence0.65
    Formation of Senescence-Associated Heterochromatin Foci (SAHF)0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for EP400
        HATs acetylate histones
    Formation of Senescence-Associated Heterochromatin Foci (SAHF)
    DNA Damage/Telomere Stress Induced Senescence



    EP400 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EP400
    Interactions:

        GeneGlobe Interaction Network for EP400

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EP400 (Q96L912, 3 ENSP000003742134) via UniProtKB, MINT, STRING, and/or I2D (see all 330)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUVBL2Q9Y2302, 3, ENSP000002214134MINT-1897564 I2D: score=2 STRING: ENSP00000221413
    MYCP011063, ENSP000003672074I2D: score=6 STRING: ENSP00000367207
    DMAP1Q9NPF53, ENSP000003126974I2D: score=4 STRING: ENSP00000312697
    CTNNB1P352223, ENSP000003444564I2D: score=1 STRING: ENSP00000344456
    SMARCA4P515323, ENSP000003507204I2D: score=1 STRING: ENSP00000350720
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0043967histone H4 acetylation IDA14966270
    GO:0043968histone H2A acetylation IDA14966270

    EP400 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EP400



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EP400 gene: 
    NM_015409.4  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333577 ENST00000389561(uc001ujn.3) ENST00000389562(uc021rgq.1)
    ENST00000332482 ENST00000330386(uc001ujj.2 uc001ujm.3 uc001ujp.3 uc010tbo.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EP400 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EP400 (see all 20):
    hsa-miR-3673 hsa-miR-520d-5p hsa-miR-4272 hsa-miR-938 hsa-miR-1297 hsa-miR-105 hsa-miR-548l hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidEP400 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EP400
    Predesigned siRNA for gene silencing in human, mouse, rat EP400
    Clone
    Products:
         
    OriGene clones in human, mouse for EP400 (see all 6)
    OriGene ORF clones in mouse, rat for EP400
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EP400 (NM_015409)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EP400
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EP400
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for EP400
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EP400
      QuantiTect SYBR Green Assays in human, mouse, rat EP400
      QuantiFast Probe-based Assays in human, mouse, rat EP400

    Selected AceView cDNA sequences (see all 333):

    AU131573 BF514982 BM457218 AI421889 BE466434 AA872634 BM669883 AI824477 
    AI640529 BM796726 BM833403 BE350681 AK127058 AI206418 BE464450 AA678219 
    CA867059 BM832158 H56061 BU070510 AW451732 BM712534 CB851525 AI089833 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EP400 (see all 16)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39a · 39b ^ 40 ^ 41a · 41b ·
    SP1:        -                                                                                                                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                  -     -   
    SP4:                                                                                                                                                  -         
    SP5:                                                                                                                                                            

    ExUns: 41c ^ 42 ^ 43a · 43b ^ 44a · 44b · 44c ^ 45a · 45b · 45c
    SP1:                                                            
    SP2:                                                            
    SP3:              -           -                                 
    SP4:              -           -                                 
    SP5:                                                            


    ECgene alternative splicing isoforms for EP400

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    EP400 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGCGTGA
    EP400 Expression
    About this image


    EP400 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    EP400 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EP400 Protein Expression

    UniProtKB/Swiss-Prot: EP400_HUMAN, Q96L91
    Tissue specificity: Ubiquitously expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for EP400 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ep4001 , 5 E1A binding protein p4001, 5 82.21(n)1
    86.49(a)1
      5 (53.69 cM)5
    755601  NM_029337.21  NP_083613.21 
     1106643735 
    chicken
    (Gallus gallus)
    Aves LOC1008577931 E1A-binding protein p400-like 69.88(n)
    71.37(a)
      100857793  XM_003642174.2  XP_003642222.2 
    lizard
    (Anolis carolinensis)
    Reptilia EP4006
    E1A binding protein p400
    66(a)
    1 ↔ 1
    GL343364.1(163123-220000)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ625377.12   -- 75.57(n)    BJ625377.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-227i14.21 si:ch211-227i14.2 60.71(n)
    58.21(a)
      562355  XM_005167262.1  XP_005167319.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dom6
    domino
    23(a)
    1 → many
    2R(17210949-17229352)
    worm
    (Caenorhabditis elegans)
    Secernentea ssl-16
    Protein SSL-1, isoform d
    21(a)
    1 → many
    III(12714566-12743929) WBGene00007027
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWR16
    Swi2/Snf2-related ATPase that is the structural co...
    23(a)
    1 → many
    IV(1135932-1140476) YDR334W


    ENSEMBL Gene Tree for EP400 (if available)
    TreeFam Gene Tree for EP400 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EP400 gene
    EP400NL2  SRCAP2  
    1 SIMAP similar gene for EP400 using alignment to 2 protein entries:     EP400_HUMAN (see all proteins):
    EP400NL

    EP400 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EP400 (see all 2831)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1133990881,2
    C--132333591(+) CAGGTCT/-GTCTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1459558961,2
    C--132432551(+) TTCAG-/TTTA  
            
    TTTAT
    1 -- us2k10--------
    rs1890902211,2
    --132432713(+) CATCAC/TTTTAC 1 -- us2k10--------
    rs1930470451,2
    --132432719(+) TTTACC/TTCACA 1 -- us2k10--------
    rs49650031,2
    C,F,A,H--132432722(-) GGCTGC/TGAGGT 1 -- us2k121Minor allele frequency- T:0.37NS EA NA WA 2348
    rs756599951,2
    C,F--132432726(+) CACAGC/ACCACA 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs1846439481,2
    --132432768(+) TTCACA/CTACAT 1 -- us2k10--------
    rs1422307181,2
    C--132432955(+) TTTAC-/TTTCTT
            
    TTTCT
    1 -- us2k10--------
    rs1421299451,2
    --132433000(+) CTTGCG/TCTGTT 1 -- us2k10--------
    rs1458037571,2
    --132433059(+) AATCA-/CCGGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EP400 (132434465 - 132565011 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EP400 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746910CNV Deletion23290073
    esv2746909CNV Deletion23290073
    esv1602214CNV Insertion17803354
    esv2512701CNV Insertion19546169
    nsv899720CNV Loss21882294
    dgv1520n71CNV Loss21882294
    dgv1522n71CNV Loss21882294
    dgv1521n71CNV Loss21882294
    dgv1519n71CNV Loss21882294
    dgv1516n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606265    OMIM disorders: --

    11 diseases for EP400:    
    About MalaCards
    ossifying fibromyxoid tumor    brain cancer    tonsillitis    colorectal cancer
    prostate cancer    prostatitis    hiv-1    thyroiditis
    breast cancer    cerebritis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for EP400:
    Ossifying fibromyxoid tumor

    EP400 for disorders           About GeneDecksing


    Export disorders for EP400 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EP400 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with EP400)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The p400 complex is an essential E1A transformation target. (PubMed id 11509179)1, 2, 3, 9 Fuchs M.... Livingston D.M. (Cell 2001)
    2. cDNAs with long CAG trinucleotide repeats from human brain. (PubMed id 9225980)1, 2, 3 Margolis R.L.... Ross C.A. (Hum. Genet. 1997)
    3. The highly conserved and multifunctional NuA4 HAT complex. (PubMed id 15196461)1, 2 Doyon Y. and Cote J. (Curr. Opin. Genet. Dev. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. (PubMed id 14966270)1, 2 Doyon Y.... Cote J. (Mol. Cell. Biol. 2004)
    7. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PubMed id 12963728)1, 2 Cai Y.... Conaway J.W. (J. Biol. Chem. 2003)
    8. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    9. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    10. Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression. (PubMed id 16601686)1, 9 Tyteca S....Trouche D. (EMBO J. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57634 HGNC: 11958 AceView: EP400 Ensembl:ENSG00000183495 euGenes: HUgn57634
    ECgene: EP400 H-InvDB: EP400

    (According to HUGE)
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    HUGE: KIAA1498 KIAA1818

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EP400 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EP400 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EP400 gene:
    Search GeneIP for patents involving EP400

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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