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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EP400 Gene

protein-coding   GIFtS: 58
GCID: GC12P132434

E1A Binding Protein P400

(Previous name: trinucleotide repeat containing 12)
(Previous symbol: TNRC12)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
E1A Binding Protein P4001 2     P400 KDa SWI2/SNF2-Related Protein2 3
TNRC121 2 3 5     KIAA14983 5
Trinucleotide Repeat Containing 121 2     P4002
Domino Homolog2 3     E1A-Binding Protein P4002
Trinucleotide Repeat-Containing Gene 12 Protein2 3     P400 SWI2/SNF2-Related Protein2
CAGH322 3     EC 3.6.4.-3
CAG Repeat Protein 322 3     KIAA18183
hDomino2 3     EC 3.6.18

External Ids:    HGNC: 119581   Entrez Gene: 576342   Ensembl: ENSG000001834957   OMIM: 6062655   UniProtKB: Q96L913   

Export aliases for EP400 gene to outside databases

Previous GC identifers: GC12U990164 GC12P132315 GC12P130928 GC12P131111 GC12P131000 GC12P129320


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for EP400 Gene: 
EP400 (E1A binding protein p400) is a protein-coding gene. Diseases associated with EP400 include colorectal cancer, and prostate cancer. GO annotations related to this gene include chromatin binding and helicase activity. An important paralog of this gene is EP400NL.

UniProtKB/Swiss-Prot: EP400_HUMAN, Q96L91
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation
of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter
nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which
positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes
during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part,
contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity

Gene Wiki entry for EP400 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009755.19  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EP400 gene promoter:
         HTF   XBP-1   CUTL1   STAT5A   HNF-4alpha2   Tal-1beta   c-Ets-1   HNF-4alpha1   E47   Pax-3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEP400 promoter sequence
   Search SABiosciences Chromatin IP Primers for EP400

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EP400


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

EP400 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EP400 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P132434:  view genomic region     (about GC identifiers)

Start:
132,434,465 bp from pter      End:
132,565,011 bp from pter
Size:
130,547 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EP400_HUMAN, Q96L91 (See protein sequence)
Recommended Name: E1A-binding protein p400  
Size: 3159 amino acids; 343489 Da
Subunit: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60
and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin,
ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. May also participate in the
formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF
related protein SRCAP. The NuA4 complex interacts with MYC and the adenovirus E1A protein. EP400 interacts with
TRRAP, RUVBL1 and RUVBL2. Interacts with ZNF42. Interacts with PHF5A (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAB91441.1; Type=Frameshift; Positions=2959, 3020; Sequence=AAH37208.1;
Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAH64554.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA96022.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened;
Secondary accessions: O15411 Q6P2F5 Q8N8Q7 Q8NE05 Q96JK7 Q9P230
Alternative splicing: 5 isoforms:  Q96L91-1   Q96L91-2   Q96L91-3   Q96L91-4   Q96L91-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EP400: NX_Q96L91

Explore proteomics data for EP400 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96L91

  • 2 DME Specific Peptides for EP400 (Q96L91)
     GLGKTVQ  NGILADE 

    EP400 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EP400 Protein Expression
    REFSEQ proteins: NP_056224.3  
    ENSEMBL proteins: 
     ENSP00000333602   ENSP00000374212   ENSP00000374213   ENSP00000331737   ENSP00000330620  

    Human Recombinant Protein Products for EP400: 
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for EP400
    GenScript Custom Purified and Recombinant Proteins Services for EP400
    Novus Biologicals EP400 Protein
    Novus Biologicals EP400 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EP400 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016607nuclear speck ISS--
    GO:0035267NuA4 histone acetyltransferase complex IDA14966270

    EP400 for ontologies           About GeneDecksing



    EP400 Antibody Products: 
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    Novus Biologicals EP400 Antibodies
    Abcam antibodies for EP400
    Cloud-Clone Corp. Antibodies for EP400 
    ThermoFisher Antibodies for EP400
    LSBio Antibodies in human, mouse, rat for EP400 

    Assay Products for EP400: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EP400 
    Cloud-Clone Corp. CLIAs for EP400


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/10 InterPro protein domains (see all 10):
     IPR006562 HSA
     IPR027417 P-loop_NTPase
     IPR013999 HAS_subgr
     IPR014012 Helicase/SANT-assoc_DNA-bd
     IPR017877 Myb-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96L91

    ProtoNet protein and cluster: Q96L91

    3 Blocks protein domains:
    IPB000330 SNF2 related domain
    IPB002464 ATP-dependent helicase
    IPB006562 HSA


    UniProtKB/Swiss-Prot: EP400_HUMAN, Q96L91
    Similarity: Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 HSA domain
    Similarity: Contains 1 Myb-like domain


    EP400 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EP400_HUMAN, Q96L91
    Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation
    of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter
    nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which
    positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes
    during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part,
    contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0004386helicase activity IEA--
    GO:0005515protein binding ----
         
    EP400 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for EP400:
     G0/1 arrest  Increased G1 DNA content  Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ep400):
     embryogenesis  hematopoietic system  mortality/aging  nervous system  no phenotypic analysis 

    EP400 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ep400tm1Fuku for EP400

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EP400 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EP400

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EP400 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EP400 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EP400
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate EP400 (see all 20):
    hsa-miR-3673 hsa-miR-520d-5p hsa-miR-4272 hsa-miR-938 hsa-miR-1297 hsa-miR-105 hsa-miR-548l hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidEP400 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EP400
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EP400

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EP400


    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for EP400 (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EP400 (NM_015409)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EP400
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EP400

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    GenScript Custom overexpressing Cell Line Services for EP400
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EP400


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EP400

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for EP400 (Q96L912, 3 ENSP000003742134) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUVBL2Q9Y2302, 3, ENSP000002214134MINT-1897564 I2D: score=2 STRING: ENSP00000221413
    MYCP011063, ENSP000003672074I2D: score=6 STRING: ENSP00000367207
    KAT5Q929933, ENSP000003403304I2D: score=4 STRING: ENSP00000340330
    CTNNB1P352223, ENSP000003444564I2D: score=1 STRING: ENSP00000344456
    RUVBL1Q9Y2653, ENSP000003182974I2D: score=1 STRING: ENSP00000318297
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043967histone H4 acetylation IDA14966270
    GO:0043968histone H2A acetylation IDA14966270

    EP400 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EP400

    Search CenterWatch for drugs/clinical trials and news about EP400

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EP400 gene: 
    NM_015409.4  

    Unigene Cluster for EP400:

    E1A binding protein p400
    Hs.723478  [show with all ESTs]
    Unigene Representative Sequence: NM_015409
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333577 ENST00000389561(uc001ujn.3) ENST00000389562(uc021rgq.1)
    ENST00000332482 ENST00000330386(uc001ujj.2 uc001ujm.3 uc001ujp.3 uc010tbo.2)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EP400
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate EP400 (see all 20):
    hsa-miR-3673 hsa-miR-520d-5p hsa-miR-4272 hsa-miR-938 hsa-miR-1297 hsa-miR-105 hsa-miR-548l hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidEP400 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EP400
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EP400
    Clone
    Products:
         
    OriGene clones in human, mouse for EP400 (see all 6)
    OriGene ORF clones in mouse, rat for EP400
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EP400 (NM_015409)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EP400
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EP400
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for EP400
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EP400
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EP400
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EP400

    Additional mRNA sequence: 

    AB040931.1 AB058721.1 AK025040.1 AK074395.1 AK096311.1 AK123893.1 AK124012.1 AK127058.1 
    AL832718.1 AY044869.1 BC016068.1 BC037208.1 BC064554.1 BC150291.1 U80743.1 

    19 DOTS entries:

    DT.218215  DT.99977410  DT.95106954  DT.100792333  DT.95106952  DT.101976899  DT.101974309  DT.100792335 
    DT.100029261  DT.100029262  DT.100792332  DT.100792336  DT.91742374  DT.95106957  DT.99951945  DT.100028287 
    DT.100779428  DT.91719275  DT.95105426 

    24/333 AceView cDNA sequences (see all 333):

    AB058721 AW024488 CA867059 AI640529 BQ716912 BM702025 BE550418 CB152099 
    BM796726 BC016068 BM673816 AI421889 CB851525 AI469849 BQ933300 BM724985 
    BM549443 AI089833 BM669883 CD244421 BM831540 BU070510 AA845350 AI867745 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for EP400 (see all 16)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39a · 39b ^ 40 ^ 41a · 41b ·
    SP1:        -                                                                                                                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                  -     -   
    SP4:                                                                                                                                                  -         
    SP5:                                                                                                                                                            

    ExUns: 41c ^ 42 ^ 43a · 43b ^ 44a · 44b · 44c ^ 45a · 45b · 45c
    SP1:                                                            
    SP2:                                                            
    SP3:              -           -                                 
    SP4:              -           -                                 
    SP5:                                                            


    ECgene alternative splicing isoforms for EP400

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EP400 expression in normal human tissues (normalized intensities)      EP400 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGCGTGA
    EP400 Expression
    About this image


    EP400 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
             breast epithelium   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Breast
             breast ; myoepithelial cells   
             breast epithelium   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             ovary ; follicle cells   
             oocyte   

    See EP400 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EP400

    SOURCE GeneReport for Unigene cluster: Hs.723478

    UniProtKB/Swiss-Prot: EP400_HUMAN, Q96L91
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for EP400
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for EP400 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ep4001 , 5 E1A binding protein p4001, 5 80.95(n)1
    84.78(a)1
      5 (53.69 cM)5
    755601  NM_029337.21  NP_083613.21 
     1106643735 
    chicken
    (Gallus gallus)
    Aves LOC1008577931 E1A-binding protein p400-like 69.58(n)
    71.21(a)
      100857793  XM_003642174.1  XP_003642222.1 
    lizard
    (Anolis carolinensis)
    Reptilia EP4006
    E1A binding protein p400
    66(a)
    1 ↔ 1
    GL343364.1(163123-220000)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ625377.12   -- 75.57(n)    BJ625377.1 
    zebrafish
    (Danio rerio)
    Actinopterygii EP400NL6
    EP400 N-terminal like
    52(a)
    1 → many
    8(46415549-46469367)
    fruit fly
    (Drosophila melanogaster)
    Insecta dom6
    domino
    13(a)
    1 → many
    2R(17210949-17229352)
    worm
    (Caenorhabditis elegans)
    Secernentea ssl-16
    Helicase ssl-1
    14(a)
    possible ortholog
    III(12714566-12743929)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWR16
    Swi2/Snf2-related ATPase that is the structural co...
    14(a)
    1 → many
    IV(1135932-1140476)


    ENSEMBL Gene Tree for EP400 (if available)
    TreeFam Gene Tree for EP400 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EP400 gene
    EP400NL2  SRCAP2  
    1 SIMAP similar gene for EP400 using alignment to 3 protein entries:     EP400_HUMAN (see all proteins):
    EP400NL

    EP400 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2831 SNPs in EP400 are shown (see all 2831)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1133990881,2
    C--132333591(+) CAGGTCT/-GTCTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1459558961,2
    C--132432551(+) TTCAG-/TTTA  
            
    TTTAT
    1 -- us2k10--------
    rs1890902211,2
    --132432713(+) CATCAC/TTTTAC 1 -- us2k10--------
    rs1930470451,2
    --132432719(+) TTTACC/TTCACA 1 -- us2k10--------
    rs49650031,2
    C,F,A,H--132432722(-) GGCTGC/TGAGGT 1 -- us2k121Minor allele frequency- T:0.37NS EA NA WA 2348
    rs756599951,2
    C,F--132432726(+) CACAGC/ACCACA 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs1846439481,2
    --132432768(+) TTCACA/CTACAT 1 -- us2k10--------
    rs1422307181,2
    C--132432955(+) TTTAC-/TTTCTT
            
    TTTCT
    1 -- us2k10--------
    rs1421299451,2
    --132433000(+) CTTGCG/TCTGTT 1 -- us2k10--------
    rs1458037571,2
    --132433059(+) AATCA-/CCGGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EP400 (132434465 - 132565011 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for EP400 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746910CNV Deletion23290073
    esv2746909CNV Deletion23290073
    esv1602214CNV Insertion17803354
    esv2512701CNV Insertion19546169
    nsv899720CNV Loss21882294
    dgv1520n71CNV Loss21882294
    dgv1522n71CNV Loss21882294
    dgv1521n71CNV Loss21882294
    dgv1519n71CNV Loss21882294
    dgv1516n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606265    OMIM disorders: --

    4 diseases for EP400:    About MalaCards
    colorectal cancer    prostate cancer    prostatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for EP400:
    Ossifying fibromyxoid tumor

    EP400 for disorders           About GeneDecksing


    Export disorders for EP400 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EP400 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with EP400)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The p400 complex is an essential E1A transformation target. (PubMed id 11509179)1, 2, 3, 9 Fuchs M.... Livingston D.M. (2001)
    2. cDNAs with long CAG trinucleotide repeats from human brain. (PubMed id 9225980)1, 2, 3 Margolis R.L.... Ross C.A. (1997)
    3. The highly conserved and multifunctional NuA4 HAT complex. (PubMed id 15196461)1, 2 Doyon Y. and Cote J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. (PubMed id 14966270)1, 2 Doyon Y.... Cote J. (2004)
    7. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PubMed id 12963728)1, 2 Cai Y.... Conaway J.W. (2003)
    8. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
    9. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    10. Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression. (PubMed id 16601686)1, 9 Tyteca S....Trouche D. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57634 HGNC: 11958 AceView: EP400 Ensembl:ENSG00000183495 euGenes: HUgn57634
    ECgene: EP400 H-InvDB: EP400

    (According to HUGE)
    About This Section
    HUGE: KIAA1498 KIAA1818

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EP400 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EP400 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EP400 gene:
    Search GeneIP for patents involving EP400

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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