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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EP400 Gene

protein-coding   GIFtS: 54
GCID: GC12P132434

E1A binding protein p400

(Previous name: trinucleotide repeat containing 12 )
(Previous symbol: TNRC12)
 Explore 4 diseases affiliated with
EP400 via our new
 Human Malady Compendium 
Biological research products
for EP400
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
E1A Binding Protein P4001 2     CAG Repeat Protein 322 3
TNRC121 2 3 5     HDomino1
CAGH321 2 3     P400 KDa SWI2/SNF2-Related Protein2 3
KIAA14981 3 5     DKFZP434I2251
P4001 2     E1A-Binding Protein P4002
Trinucleotide Repeat Containing 121 2     P400 SWI2/SNF2-Related Protein2
KIAA18181 3     EC 3.6.4.-3
Domino Homolog2 3     EC 3.6.18
Trinucleotide Repeat-Containing Gene 12 Protein2 3     

External Ids:    HGNC: 119581   Entrez Gene: 576342   Ensembl: ENSG000001834957   OMIM: 6062655   UniProtKB: Q96L913   

Export aliases for EP400 gene to outside databases

Previous GC identifers: GC12U990164 GC12P132315 GC12P130928 GC12P131111 GC12P131000 GC12P129320


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: EP400_HUMAN, Q96L91
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of
select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter
nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively
regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular
proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the
association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity

Gene Wiki entry for EP400


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EP400 gene promoter:
         HTF   XBP-1   CUTL1   STAT5A   HNF-4alpha2   Tal-1beta   c-Ets-1   HNF-4alpha1   E47   Pax-3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEP400 promoter sequence
   Search SABiosciences Chromatin IP Primers for EP400

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EP400


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

EP400 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EP400 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P132434:  view genomic region     (about GC identifiers)

Start:
132,434,505 bp from pter      End:
132,565,005 bp from pter
Size:
130,501 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: EP400_HUMAN, Q96L91 (See protein sequence)
Recommended Name: E1A-binding protein p400  
Size: 3159 amino acids; 343489 Da
Subunit: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and
the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A,
MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. May also participate in the formation of NuA4
related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP.
The NuA4 complex interacts with MYC and the adenovirus E1A protein. EP400 interacts with TRRAP, RUVBL1 and RUVBL2.
Interacts with ZNF42. Interacts with PHF5A (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAB91441.1; Type=Frameshift; Positions=2959, 3020; Sequence=AAH37208.1; Type=Miscellaneous
discrepancy; Note=Intron retention; Sequence=AAH64554.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.
Potential poly-A sequence; Sequence=BAA96022.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O15411 Q6P2F5 Q8N8Q7 Q8NE05 Q96JK7 Q9P230
Alternative splicing: 5 isoforms:  Q96L91-1   Q96L91-2   Q96L91-3   Q96L91-4   Q96L91-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EP400: NX_Q96L91

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96L91

  • 2 DME Specific Peptides for EP400 (Q96L91)
     GLGKTVQ  NGILADE 

    EP400 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056224.3  
    ENSEMBL proteins: 
     ENSP00000442702   ENSP00000404699   ENSP00000439509   ENSP00000440558   ENSP00000333602  
     ENSP00000374212   ENSP00000374213   ENSP00000331737   ENSP00000330620  

    Human Recombinant Protein Products: 
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for EP400 
    GenScript Custom Purified and Recombinant Proteins Services for EP400
    Novus Biologicals EP400 Protein
    Novus Biologicals EP400 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EP400

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016607nuclear speck ISS--
    GO:0035267NuA4 histone acetyltransferase complex IDA14966270


    EP400 for ontologies           About GeneDecksing



    EP400 Antibody Products: 
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    Uscn ELISAs and CLIAs for EP400


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    EP400 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR006562 HSA
     IPR013999 HAS_subgr
     IPR014012 Helicase/SANT-assoc_DNA-bd
     IPR017877 Myb-like_dom
     IPR000330 SNF2_N

    Graphical View of Domain Structure for InterPro Entry Q96L91

    ProtoNet protein and cluster: Q96L91

    3 Blocks protein families:
    IPB000330 SNF2 related domain
    IPB002464 ATP-dependent helicase
    IPB006562 HSA


    UniProtKB/Swiss-Prot: EP400_HUMAN, Q96L91
    Similarity: Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 HSA domain
    Similarity: Contains 1 Myb-like domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: EP400_HUMAN, Q96L91
    Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of
    select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter
    nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively
    regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular
    proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the
    association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity

    Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.-1

    miRNA
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    hsa-miR-3673 hsa-miR-520d-5p hsa-miR-4272 hsa-miR-938 hsa-miR-1297 hsa-miR-105 hsa-miR-548l hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidEP400 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EP400

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0004386helicase activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--


    EP400 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for EP400:
     G0/1 arrest  Increased G1 DNA content  Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Ep400tm1Fuku for EP400
         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ep400):
     embryogenesis  hematopoietic system  mortality/aging  nervous system  no phenotypic analysis 

    EP400 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EP400

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for EP400 (Q96L912, 3 ENSP000003742134) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUVBL2Q9Y2302, 3, ENSP000002214134MINT-1897564 I2D: score=2 STRING: ENSP00000221413
    MYCP011063, ENSP000003672074I2D: score=6 STRING: ENSP00000367207
    KAT5Q929933, ENSP000003403304I2D: score=4 STRING: ENSP00000340330
    CTNNB1P352223, ENSP000003444564I2D: score=1 STRING: ENSP00000344456
    RUVBL1Q9Y2653, ENSP000003182974I2D: score=1 STRING: ENSP00000318297
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043967histone H4 acetylation IDA14966270
    GO:0043968histone H2A acetylation IDA14966270


    EP400 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EP400
    Search CenterWatch for drugs/clinical trials and news about EP400 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EP400 gene: 
    NM_015409.4  

    Unigene Cluster for EP400:

    E1A binding protein p400
    Hs.595201  [show with all ESTs]
    Unigene Representative Sequence: NM_015409
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537902 ENST00000423130(uc001ujk.3) ENST00000541296 ENST00000542457
    ENST00000542712 ENST00000333577 ENST00000389561(uc001ujn.3) ENST00000389562(uc021rgq.1)
    ENST00000332482 ENST00000330386(uc001ujj.2 uc001ujm.3 uc001ujp.3 uc010tbo.2)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EP400
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate EP400 (see all 20):
    hsa-miR-3673 hsa-miR-520d-5p hsa-miR-4272 hsa-miR-938 hsa-miR-1297 hsa-miR-105 hsa-miR-548l hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidEP400 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EP400 (see all 6)
    OriGene siRNA: EP400
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EP400
    Clone
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    GenScript: all cDNA clones in your preferred vector: EP400 (NM_015409)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EP400 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EP400
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EP400

    Additional cDNA sequence: 

    AB040931.1 AB058721.1 AK025040.1 AK074395.1 AK096311.1 AK123893.1 AK124012.1 AK127058.1 
    AL832718.1 AY044869.1 BC016068.1 BC037208.1 BC064554.1 BC150291.1 U80743.1 

    17 DOTS entries:

    DT.218215  DT.99977410  DT.95106954  DT.100792333  DT.95106952  DT.101976899  DT.101974309  DT.100792335 
    DT.100029261  DT.100029262  DT.100792332  DT.100792336  DT.91742374  DT.95106957  DT.100028287  DT.91719275 
    DT.95105426 

    24/333 AceView cDNA sequences (see all 333):

    AA973376 CB159600 BU070510 AL832718 CD244421 AI051708 AI631806 BM478108 
    AU131584 BU173408 AI636129 BQ649918 Z41807 AK096311 AI206418 AI089833 
    BE350681 BQ716912 AW294118 BM693458 AI867745 CB851525 BQ941775 AI469849 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for EP400 (see all 16)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39a · 39b ^ 40 ^ 41a · 41b ·
    SP1:        -                                                                                                                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                  -     -   
    SP4:                                                                                                                                                  -         
    SP5:                                                                                                                                                            

    ExUns: 41c ^ 42 ^ 43a · 43b ^ 44a · 44b · 44c ^ 45a · 45b · 45c
    SP1:                                                            
    SP2:                                                            
    SP3:              -           -                                 
    SP4:              -           -                                 
    SP5:                                                            


    ECgene alternative splicing isoforms for EP400

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EP400 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTGGCGTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See EP400 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EP400

    SOURCE GeneReport for Unigene cluster: Hs.595201

    UniProtKB/Swiss-Prot: EP400_HUMAN, Q96L91
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for EP400
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EP400

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EP400 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC1008577931 E1A-binding protein p400-like 69.58(n)
    71.21(a)
      100857793  XM_003642174.1  XP_003642222.1 
    lizard
    (Anolis carolinensis)
    Reptilia EP4006
    --
    67(a)
    1 → many
    GL343364.1(163148-217793)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ625377.12   -- 75.57(n)    BJ625377.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-227i14.26
    si:ch211-227i14.2
    54(a)
    1 → many
    8(46415549-46469367)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G248806
    AT3G248706
    Helicase/SANT-associated, DNA binding protein
    14(a)
    14(a)
    many ↔ many
    many ↔ many
    3(9086242-9095537)
    3(9074665-9085048)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    DNA binding protein, putative, expressed
    12(a)
    12(a)
    1 ↔ many
    possible ortholog
    8(4522654-4531059)
    5(29492138-29497235)


    ENSEMBL Gene Tree for EP400 (if available)
    TreeFam Gene Tree for EP400 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EP400 gene
    EP400NL2  SRCAP2  
    1 SIMAP similar gene for EP400 using alignment to 3 protein entries:     EP400_HUMAN (see all proteins):
    EP400NL

    EP400 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2296 NCBI SNPs in EP400 are shown (see all 2296    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1459558961,2
    C,--132432551(+) TTCAG-/TTTA  
            
    TTTAT
    1 -- us2k10--------
    rs1890902211,2
    --132432713(+) CATCAC/TTTTAC 1 -- us2k10--------
    rs1930470451,2
    --132432719(+) TTTACC/TTCACA 1 -- us2k10--------
    rs49650031,2
    C,F,A,H,--132432722(-) GGCTGC/TGAGGT 1 -- us2k121Minor allele frequency- T:0.37NS EA NA WA 2348
    rs756599951,2
    F,--132432726(+) CACAGC/ACCACA 1 -- us2k11Minor allele frequency- A:0.04EA 120
    rs1846439481,2
    --132432768(+) TTCACA/CTACAT 1 -- us2k10--------
    rs1422307181,2
    C,--132432955(+) TTTAC-/TTTCTT
            
    TTTCT
    1 -- us2k10--------
    rs1421299451,2
    --132433000(+) CTTGCG/TCTGTT 1 -- us2k10--------
    rs1458037571,2
    --132433058(+) AATCA-/CCGGCT 1 -- us2k10--------
    rs1890163701,2
    --132433061(+) ATCACA/GGCTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EP400 (132434505 - 132565005 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for EP400
         1 CNV: 8742
         4 Indels: 60108 101658 86683 76232

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EP400
    DNA2.0 Custom Variant and Variant Library Synthesis for EP400

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    EP400 for disorders           About GeneDecksing

    OMIM gene information: 606265    OMIM disorders: --

    4 diseases for EP400:    About MalaCards
    colorectal cancer    prostate cancer    prostatitis    malaria


    Export disorders for EP400 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EP400 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with EP400)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The p400 complex is an essential E1A transformation target. (PubMed id 11509179)1, 2, 3, 9 Fuchs M.... Livingston D.M. (2001)
    2. cDNAs with long CAG trinucleotide repeats from human brain. (PubMed id 9225980)1, 2, 3 Margolis R.L.... Ross C.A. (1997)
    3. The highly conserved and multifunctional NuA4 HAT complex. (PubMed id 15196461)1, 2 Doyon Y. and Cote J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. (PubMed id 14966270)1, 2 Doyon Y.... Cote J. (2004)
    7. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PubMed id 12963728)1, 2 Cai Y.... Conaway J.W. (2003)
    8. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
    9. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    10. Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression. (PubMed id 16601686)1, 9 Tyteca S....Trouche D. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57634 HGNC: 11958 AceView: EP400 Ensembl:ENSG00000183495 euGenes: HUgn57634
    ECgene: EP400 H-InvDB: EP400

    (According to HUGE)
    About This Section
    HUGE: KIAA1498 KIAA1818

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EP400 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EP400 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EP400 gene:
    Search GeneIP for patents involving EP400

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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