EP300 Gene
protein-coding GIFtS: 70
GCID: GC22P041487
|
|
E1A binding protein p300
| |
Aliases
for EP300 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| E1A Binding Protein P3001 2 | | RSTS22 5 | | KAT3B1 2 | | E1A-Binding Protein, 300kD2 | | P3003 | | Histone Acetyltransferase P3002 | | E1A-Associated Protein P3002 3 | | P3003 | | P300 HAT2 3 | | EC 2.3.18 | | EC 2.3.1.483 8 | | |
Export aliases for EP300 gene to outside databasesPrevious GC identifers: GC22P038102 GC22P039730 GC22P039812 GC22P024453 |
Summaries
for EP300 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for EP300:
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions ashistone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes ofcell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylatedCREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), andthus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause ofRubinstein-Taybi syndrome and may also play a role in epithelial cancer. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: EP300_HUMAN, Q09472Function: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates allfour core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation.Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions asacetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence ofCREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 throughacetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation andmodulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a roleas a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminaldifferentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediatetranscriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein.In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and mayhelp inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity
Gene Wiki entry for EP300
|
Genomic Views
for EP300 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EP300 gene promoter:
MEF-2A PPAR-alpha AP-1 ATF-2 c-Jun aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for EP300
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EP300 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.2 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2EP300 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P041487: view genomic region
(about GC identifiers)
Start:
|
41,487,790 bp from pter |
End:
|
41,576,081 bp from pter |
Size:
|
88,292 bases |
Orientation:
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plus strand |
|
Proteins
for EP300 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EP300_HUMAN, Q09472 (See
protein sequence)Recommended Name: Histone acetyltransferase p300 Size: 2414 amino acids; 264161 Da
Subunit: Interacts with phosphorylated CREB1 (By similarity). Interacts with HIF1A; the interaction is stimulated inresponse to hypoxia and inhibited by CITED2. Interacts (via N-terminus) with TFAP2A (via N-terminus); the interactionrequires CITED2. Interacts (via CH1 domain) with CITED2 (via C-terminus). Interacts with CITED1 (unphosphorylated formpreferentially and via C-terminus). Interacts with ESR1; the interaction is estrogen-dependent and enhanced by CITED1.Interacts with DTX1, EID1, ELF3, FEN1, LEF1, NCOA1, NCOA6, NR3C1, PCAF, PELP1, PRDM6, SP1, SP3, SPIB, SRY, TCF7L2,TP53, DDX5, DDX17, SATB1, SRCAP, TTC5, JMY and TRERF1. The TAZ-type 1 domain interacts with HIF1A. Probably part of acomplex with HIF1A and CREBBP. Part of a complex containing CARM1 and NCOA2/GRIP1. Interacts with ING4 and thisinteraction may be indirect. Interacts with ING5. Interacts with the C-terminal region of CITED4. Interacts withHTLV-1 Tax and p30II. Interacts with and acetylates HIV-1 Tat. Non-sumoylated EP300 preferentially interacts withSENP3. Interacts with SS18L1/CREST. Interacts with ALX1 (via homeobox domain). Interacts with NEUROD1; the interactionis inhibited by NR0B2. Interacts with TCF3. Interacts (via CREB-binding domain) with MYOCD (via C-terminus) (Bysimilarity). Binds to HIPK2 (By similarity). Interacts with ROCK2 and PPARG. Forms a complex made of CDK9,CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. Interacts with IRF1 and thisinteraction enhances acetylation of p53/TP53 and stimulation of its activity. Interacts with FOXO1; the interactionacetylates FOXO1 and enhances its transcriptional activity. Interacts with DDIT3/CHOP
Subcellular location: Cytoplasm. Nucleus. Note=In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.Co-localizes with ROCK2 in the nucleus
6/8 PDB 3D structures from  and Proteopedia  for EP300 (see all 8):1L3E (3D)
1P4Q (3D)
2K8F (3D)
3BIY (3D)
3I3J (3D)
3IO2 (3D)
Secondary accessions: B1AKC2Explore the universe of human proteins at neXtProt for EP300: NX_Q09472
Post-translational modifications:
Acetylated on Lys at up to 17 positions by intermolecular autocatalysis. Deacetylated in the transcriptional repressiondomain (CRD1) by SIRT1, preferentially at Lys-10201
Citrullinated at Arg-2142 by PADI4, which impairs methylation by CARM1 and promotes interaction with NCOA2/GRIP11
Methylated at Arg-580 and Arg-604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREBsignaling and activates apoptotic response. Also methylated at Arg-2142 by CARM1, which impairs interaction withNCOA2/GRIP11
Sumoylated; sumoylation in the transcriptional repression domain (CRD1) mediates transcriptional repression.Desumoylated by SENP3 through the removal of SUMO2 and SUMO31
Probable target of ubiquitination by FBXO3, leading to rapid proteasome-dependent degradation1
Phosphorylated by HIPK2 in a RUNX1-dependent manner. This phosphorylation that activates EP300 happens when RUNX1 isassociated with DNA and CBFB. Phosphorylated by ROCK2 and this enhances its activity. Phosphorylation at Ser-89 byAMPK reduces interaction with nuclear receptors, such as PPARG1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q09472
4 DME Specific Peptides for EP300 (Q09472)
EP300 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001420.2
ENSEMBL proteins: ENSP00000263253 Reactome Protein details: Q09472
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
EP300 for ontologies About GeneDecksing
EP300 Antibody Products:
Assay Products for EP300: |
Protein
Domains /
Families
for EP300 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EP300 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q09472ProtoNet protein and cluster: Q09472 5 Blocks protein families: IPB000197 TAZ finger IPB000433 Zn-finger IPB001487 Bromodomain signature IPB003101 Coactivator CBP IPB009255 Transcriptional coactivation
UniProtKB/Swiss-Prot: EP300_HUMAN, Q09472Domain: The CRD1 domain (cell cycle regulatory domain 1) mediates transcriptional repression of a subset of p300responsive genes; it can be de-repressed by CDKN1A/p21WAF1 at least at some promoters. It conatins sumoylation andacetylation sites and the same lysine residues may be targeted for the respective modifications. It is proposed thatdeacetylation by SIRT1 allows sumoylation leading to suppressed activitySimilarity: Contains 1 bromo domainSimilarity: Contains 1 KIX domainSimilarity: Contains 2 TAZ-type zinc fingersSimilarity: Contains 1 ZZ-type zinc finger |
Function
for EP300 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: EP300_HUMAN, Q09472Function: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates allfour core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation.Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions asacetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence ofCREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 throughacetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation andmodulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a roleas a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminaldifferentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediatetranscriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein.In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and mayhelp inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activityCatalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone] Genatlas biochemistry entry for EP300:cellular protein p300,component with CREBBP of a coactivator complex connecting the basal transcriptional machinery tovarious DNA binding factors,i.e. binding the promoter of FTH1 and contributing to its tissue specificexpression,target of adenoviral E1A oncoprotein,structurally and putatively preventing the G0/G1 transition in cellcycle,also acting as an histone acetyltransferase for the four core histones in nucleosome,involved in acute myeloidleukemia with translocation t(11;22)(q23;q13)
Enzyme Numbers (IUBMB): EC 2.3.1.481 2 EC 2.3.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EP300 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EP300
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EP300 (NM_001429) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EP300 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EP300 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EP300 |
Gene Ontology (GO): 5/29 molecular function terms (GO ID links to tree view) (see all 29): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding |
-- | -- | | GO:0001047 | core promoter binding |
IDA | 17641689 | | GO:0001085 | RNA polymerase II transcription factor binding |
-- | -- | | GO:0001102 | RNA polymerase II activating transcription factor binding |
IPI | -- | | GO:0002039 | p53 binding |
IEA | -- |
EP300 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for EP300:
Animal Models:
Mouse knock-out Ep300tm1Dli for EP300
15/16 MGI mutant phenotypes (inferred from 7 alleles ) (MGI details for Ep300) (see all 16):
EP300 for phenotypes About GeneDecksing
|
Pathways & Interactions
for EP300 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/102 super-pathways (see all 102) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant | | | 2 | Development_Ligand-dependent activation of the ESR1/AP-1 pathway | | | 3 | Immune response_IFN gamma signaling pathway | | | 4 | CREB Pathway | | | 5 | Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/18 EMD Millipore Pathways for EP300 (see all 18)
5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EP300 (see all 33)
2 
Cell Signaling Technology (CST) Pathways for EP300
5/18  GeneGo (Thomson Reuters) Pathways for EP300 (see all 18)
5/40  BioSystems Pathways for EP300 (see all 40)
5/26 
Reactome Pathways for EP300 (see all 26)
5/14 
Kegg Pathways (Kegg details for EP300) (see all 14):
EP300 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EP300
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/648 Interacting proteins for EP300 (Q094721, 2, 3 ENSP000002632534) via UniProtKB, MINT, STRING, and/or I2D (see all 648)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| HIF1A | Q166651, 2, 3, ENSP000003380184 | EBI-3908041,EBI-447269 MINT-6802121 MINT-7943730 MINT-7943746 MINT-4791660 MINT-4791678 MINT-6802156 MINT-4652938 MINT-4791632 I2D:
score=7 STRING: ENSP00000338018 | | TP53 | P046371, 2, 3, ENSP000002693054 | EBI-3908041,EBI-366083 MINT-69507 MINT-8152513 MINT-8152530 MINT-8392126 MINT-2830826 MINT-7263630 MINT-8152544 MINT-6628507 I2D:
score=7 STRING: ENSP00000269305 | | HIST1H4A | P628053, ENSP000003529804 | I2D:
score=2 STRING: ENSP00000352980 | | HIST4H4 | P628053, ENSP000003507674 | I2D:
score=2 STRING: ENSP00000350767 | | HIST1H4B | P628053 | I2D:
score=2 |
About this table
Gene Ontology (GO): 5/62 biological process terms (GO ID links to tree view) (see all 62): About this table
EP300 for ontologies About GeneDecksing
|
Drugs & Compounds
for EP300 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
EP300 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for EP300 |
 Browse Tocris compounds for EP300
3 HMDB Compounds for EP300 About this table
10/59 Novoseek chemical compound relationships for EP300 gene (see all 59) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| helenalin |
62.3 |
1 |
19717552 (1) |
| lysine |
57.4 |
39 |
18753126 (3), 18655826 (3), 11279135 (2), 19949111 (2) (see all 27) |
| polypropylene glycol |
50.9 |
6 |
17486071 (2), 8290250 (1), 15220443 (1), 16862175 (1) |
| retinoic acid |
48.5 |
50 |
16581781 (5), 7628451 (5), 10780452 (3), 10475063 (3) (see all 21) |
| curcumin |
45.8 |
17 |
16638200 (4), 16787365 (3), 17927689 (2), 18227124 (1) (see all 9) |
| retinoid |
43.8 |
8 |
12205093 (1), 15731352 (1), 12646247 (1), 11641790 (1) (see all 6) |
| steroid |
43.5 |
35 |
12456802 (3), 12697832 (2), 12586842 (2), 12656669 (1) (see all 24) |
| estrogen |
43.2 |
24 |
11010967 (2), 10567538 (2), 19188451 (2), 9450928 (1) (see all 18) |
| ly294002 |
36.8 |
4 |
15224190 (1), 20333651 (1), 12808085 (1), 17299794 (1) |
| butyrate |
35.7 |
8 |
10899165 (3), 12456802 (2), 12840224 (1), 10207071 (1) (see all 5) |
Search CenterWatch for drugs/clinical trials and news about EP300
|
Transcripts
for EP300 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EP300 gene: NM_001429.3 Unigene Cluster for EP300: E1A binding protein p300 Hs.517517 [show with all ESTs]Unigene Representative Sequence: U018771 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000263253(uc003azl.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EP300 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EP300
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: EP300 (NM_001429) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EP300 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EP300 |
Additional cDNA sequence: AK125679.1 BC053889.1 U01877.1 14 DOTS entries: DT.317177 DT.120670575 DT.75185151 DT.305170 DT.40110251 DT.92047060 DT.92436790 DT.95250753 DT.317172 DT.40306607 DT.92412601 DT.95206497 DT.120670582 DT.75165804 24/283 AceView cDNA sequences (see all 283): AI290302 BQ218230 BM836491 N58429 H55463 AW172862 AI079333 BE351044 BX098158 CA434775 T06350 CB155618 AA371383 BU677921 BG011506 AI424548 BI051150 BF895883 CB128649 BQ434736 AA236852 BC053889 BQ334732 BQ881188
GeneLoc Exon Structure
|
Expression
for EP300 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EP300 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See EP300 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EP300
SOURCE GeneReport for Unigene cluster: Hs.517517
SABiosciences Expression via Pathway-Focused PCR Arrays including EP300 (see all 15): | Neurogenesis in human mouse rat | | HIV Host Response in human mouse rat | | Epigenetic Chromatin Modification Enzymes in human mouse rat | | Stem Cell Transcription Factors in human mouse rat | | WNT Signaling Pathway in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EP300
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EP300 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EP300 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EP300 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EP300 |
Orthologs
for EP300 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for EP300 gene from 8/26 species (see all 26) About this table
ENSEMBL Gene Tree for EP300 (if available)
TreeFam Gene Tree for EP300 (if available) |
Paralogs
for EP300 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EP300 gene
- BRDT2 BRD42 CREBBP2 BRD22 BRD32
6 SIMAP similar genes for EP300 using alignment to 2 protein entries: EP300_HUMAN (see all proteins):CREBBP CBP CREB-binding protein MORF/CBP MOZ/CBP BRDT
EP300 for paralogs About GeneDecksing
|
Genomic Variants
for EP300 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EP300 (41487790 - 41576081 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for EP300: --
Human Gene Mutation Database (HGMD): EP300
Locus Specific Mutation Databases (LSDB): EP300
| 2 SABiosciences Cancer Mutation PCR Assays for EP300: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EP300 |
|
Disorders
/ Diseases
for EP300 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EP300 for disorders About GeneDecksing
OMIM gene information: 602700
OMIM disorders: 114500 613684
UniProtKB/Swiss-Prot: EP300_HUMAN, Q09472
Note=Defects in EP300 may play a role in epithelial cancer Note=Chromosomal aberrations involving EP300 may be a cause of acute myeloid leukemias. Translocationt(8;22)(p11;q13) with KAT6A Defects in EP300 are the cause of Rubinstein-Taybi syndrome type 2 (RSTS2) [MIM:613684]. A disordercharacterized by craniofacial abnormalities, postnatal growth deficiency, broad thumbs, broad big toes, mentalretardation and a propensity for development of malignancies. Some individuals with RSTS2 have less severe mentalimpairment, more severe microcephaly, and a greater degree of changes in facial bone structure than RSTS1 patients
20/95  diseases for EP300 (see all 95): About MalaCardsrubinstein-taybi syndrome rubinstein-taybi syndrome 2 rothmund-thomson syndrome hypoxia
human t-cell leukemia virus type 1 patent ductus arteriosus monocytic leukemia short stature
acute monocytic leukemia type 2 diabetes mellitus spina bifida squamous cell carcinoma
weaver syndrome b-cell lymphomas oral squamous cell carcinoma prosopagnosia
lymphoblastic leukemia esophageal squamous cell carcinoma intellectual disability leukemia
1 disease from the University of Copenhagen DISEASES database for EP300:Rubinstein-Taybi syndrome 10/57 Novoseek disease relationships for EP300 gene (see all 57) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rubinstein-taybi syndrome |
81.3 |
13 |
17299436 (2), 19353645 (2), 11962765 (1), 15706485 (1) (see all 10) |
| leukemia t-cell |
60.5 |
6 |
11264182 (1), 18815299 (1), 10744749 (1), 9528808 (1) (see all 5) |
| retinoblastoma |
53.4 |
21 |
8331729 (2), 2143024 (1), 7523245 (1), 15741165 (1) (see all 17) |
| leukemogenesis |
51.4 |
8 |
18695000 (2), 18809579 (1), 10824998 (1), 15312679 (1) (see all 7) |
| promyelocytic leukemia |
44 |
2 |
10893273 (1), 15964811 (1) |
| tumors |
43.8 |
76 |
18459105 (4), 20097195 (3), 17725108 (3), 19047049 (3) (see all 52) |
| cancer |
30.7 |
42 |
12696060 (6), 10700188 (4), 14732695 (3), 17965222 (2) (see all 20) |
| prostate cancer |
29.1 |
31 |
17409453 (5), 15705864 (4), 15994976 (4), 10344722 (3) (see all 15) |
| mental retardation |
25.3 |
1 |
17299436 (1) |
| breast cancer |
22.2 |
12 |
16867872 (5), 20097195 (2), 19183483 (1), 16928824 (1) (see all 6) |
GeneTests: EP300
Rubinstein-Taybi Syndrome
Human Genome Epidemiology (HuGE) Navigator: EP300 (15 documents)
Export disorders for EP300 gene to outside databases
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Publications
for EP300 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EP300 gene, integrated from 9 sources (see all 1220):
(articles sorted by number of sources associating them with EP300) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and functional analysis of the adenovirus E1A- associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. (PubMed id 7523245)1, 2, 3, 9 Eckner R.... Livingston D.M. (1994)
- Acetylation of Sirt2 by p300 attenuates its deacetylase activity. (PubMed id 18722353)1, 2, 9 Han Y....Lee K.Y. (2008)
- A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation. (PubMed id 10733570)1, 2, 9 Snowden A.W....Perkins N.D. (2000)
- HIV-1 tat transcriptional activity is regulated by acetylation. (PubMed id 10545121)1, 2, 9 Kiernan R.E....Van Lint C. (1999)
- Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300. (PubMed id 9528808)1, 2, 9 Bex F.... Gaynor R.B. (1998)
- Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation. (PubMed id 19217391)1, 2, 9 Feng H.... Bai Y. (2009)
- Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86. (PubMed id 15075319)1, 2, 9 Wang H.... Oettgen P. (2004)
- Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53. (PubMed id 15509808)1, 2, 9 Dornan D....Ball K.L. (2004)
- Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. (PubMed id 15186775)1, 2, 9 An W.... Roeder R.G. (2004)
- p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. (PubMed id 12750254)1, 2, 9 Shiseki M....Harris C.C. (2003)
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External Searches for EP300 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing EP300 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EP300 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EP300 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for EP300 | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for EP300 | Genetics and Cytogenetics in Oncology and Haematology | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/EP300 | | Wikipedia | http://en.wikipedia.org/wiki/P300/CBP |
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About This Section
| Patent Information for EP300 gene:
Search GeneIP for patents involving EP300
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for EP300 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for EP300 | | OriGene shRNA RFP for EP300 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EP300 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EP300 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EP300 | | OriGene 3'-UTR Clone for EP300 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EP300 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EP300 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for EP300 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EP300 | | OriGene Custom Protein Services for EP300 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EP300 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EP300 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EP300 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EP300 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EP300 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EP300 |
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| | | | Search Tocris compounds for EP300 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EP300 |
|  |  |  | | | | ThermoFisher Antibody for EP300 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EP300 |
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