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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EP300 Gene

protein-coding   GIFtS: 73
GCID: GC22P041487

E1A Binding Protein P300

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
E1A Binding Protein P3001 2     KAT3B2
Histone Acetyltransferase P3001 2     E1A-Binding Protein, 300kD2
E1A-Associated Protein P3002 3     p3002
P300 HAT2 3     P3003
EC 2.3.1.483 8     EC 2.3.18
RSTS22 5     

External Ids:    HGNC: 33731   Entrez Gene: 20332   Ensembl: ENSG000001003937   OMIM: 6027005   UniProtKB: Q094723   

Export aliases for EP300 gene to outside databases

Previous GC identifers: GC22P038102 GC22P039730 GC22P039812 GC22P024453


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EP300 Gene:
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions
as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the
processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to
phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible
factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this
gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. (provided by RefSeq,
Jul 2008)

GeneCards Summary for EP300 Gene: 
EP300 (E1A binding protein p300) is a protein-coding gene. Diseases associated with EP300 include mn1, and ep300-related rubinstein-taybi syndrome, and among its related super-pathways are Cell cycle and IFN-gamma pathway. GO annotations related to this gene include transcription coactivator activity and chromatin binding. An important paralog of this gene is BRDT.

UniProtKB/Swiss-Prot: EP300_HUMAN, Q09472
Function: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates
all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional
activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions
as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the
presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53
through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its
inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence
of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and
controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement.
Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the
adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's
transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and
enhances its transcriptional activity

Gene Wiki entry for EP300 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EP300 gene promoter:
         MEF-2A   PPAR-alpha   AP-1   ATF-2   c-Jun   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): EP300 promoter sequence
   Search SABiosciences Chromatin IP Primers for EP300

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EP300


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

EP300 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EP300 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P041487:  view genomic region     (about GC identifiers)

Start:
41,487,790 bp from pter      End:
41,576,081 bp from pter
Size:
88,292 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EP300_HUMAN, Q09472 (See protein sequence)
Recommended Name: Histone acetyltransferase p300  
Size: 2414 amino acids; 264161 Da
Subunit: Interacts with phosphorylated CREB1 (By similarity). Interacts with HIF1A; the interaction is stimulated
in response to hypoxia and inhibited by CITED2. Interacts (via N-terminus) with TFAP2A (via N-terminus); the
interaction requires CITED2. Interacts (via CH1 domain) with CITED2 (via C-terminus). Interacts with CITED1
(unphosphorylated form preferentially and via C-terminus). Interacts with ESR1; the interaction is
estrogen-dependent and enhanced by CITED1. Interacts with DTX1, EID1, ELF3, FEN1, LEF1, NCOA1, NCOA6, NR3C1,
PCAF, PELP1, PRDM6, SP1, SP3, SPIB, SRY, TCF7L2, TP53, DDX5, DDX17, SATB1, SRCAP, TTC5, JMY and TRERF1. The
TAZ-type 1 domain interacts with HIF1A. Probably part of a complex with HIF1A and CREBBP. Part of a complex
containing CARM1 and NCOA2/GRIP1. Interacts with ING4 and this interaction may be indirect. Interacts with ING5.
Interacts with the C-terminal region of CITED4. Interacts with HTLV-1 Tax and p30II. Interacts with and
acetylates HIV-1 Tat. Non-sumoylated EP300 preferentially interacts with SENP3. Interacts with SS18L1/CREST.
Interacts with ALX1 (via homeobox domain). Interacts with NEUROD1; the interaction is inhibited by NR0B2.
Interacts with TCF3. Interacts (via CREB-binding domain) with MYOCD (via C-terminus) (By similarity). Binds to
HIPK2 (By similarity). Interacts with ROCK2 and PPARG. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and
GATA4 that stimulates hypertrophy in cardiomyocytes. Interacts with IRF1 and this interaction enhances
acetylation of p53/TP53 and stimulation of its activity. Interacts with FOXO1; the interaction acetylates FOXO1
and enhances its transcriptional activity. Interacts with DDIT3/CHOP
Subcellular location: Cytoplasm. Nucleus. Note=In the presence of ALX1 relocalizes from the cytoplasm to the
nucleus. Co-localizes with ROCK2 in the nucleus
6/8 PDB 3D structures from and Proteopedia for EP300 (see all 8):
1L3E (3D)        1P4Q (3D)        2K8F (3D)        3BIY (3D)        3I3J (3D)        3IO2 (3D)    
Secondary accessions: B1AKC2

Explore the universe of human proteins at neXtProt for EP300: NX_Q09472

Explore proteomics data for EP300 at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylated on Lys at up to 17 positions by intermolecular autocatalysis. Deacetylated in the transcriptional
    repression domain (CRD1) by SIRT1, preferentially at Lys-1020
  • UniProtKB: Citrullinated at Arg-2142 by PADI4, which impairs methylation by CARM1 and promotes interaction with NCOA2/GRIP1
  • UniProtKB: Methylated at Arg-580 and Arg-604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB
    signaling and activates apoptotic response. Also methylated at Arg-2142 by CARM1, which impairs interaction with
    NCOA2/GRIP1
  • UniProtKB: Sumoylated; sumoylation in the transcriptional repression domain (CRD1) mediates transcriptional repression.
    Desumoylated by SENP3 through the removal of SUMO2 and SUMO3
  • UniProtKB: Probable target of ubiquitination by FBXO3, leading to rapid proteasome-dependent degradation
  • UniProtKB: Phosphorylated by HIPK2 in a RUNX1-dependent manner. This phosphorylation that activates EP300 happens when RUNX1
    is associated with DNA and CBFB. Phosphorylated by ROCK2 and this enhances its activity. Phosphorylation at
    Ser-89 by AMPK reduces interaction with nuclear receptors, such as PPARG
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q09472

  • 4 DME Specific Peptides for EP300 (Q09472)
     PTPHHTP  LIGYLEY  PNQRRVY  VYHEILIGYL 

    EP300 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EP300 Protein Expression
    REFSEQ proteins: NP_001420.2  
    ENSEMBL proteins: 
     ENSP00000263253  
    Reactome Protein details: Q09472
    Human Recombinant Protein Products for EP300: 
    EMD Millipore Purified and/or Recombinant EP300 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for EP300
    OriGene Purified Protein for EP300
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for EP300 
    OriGene Custom Protein Services for EP300
    GenScript Custom Purified and Recombinant Proteins Services for EP300
    Novus Biologicals EP300 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EP300 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000123histone acetyltransferase complex IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--

    EP300 for ontologies           About GeneDecksing



    EP300 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of EP300
    R&D Systems Antibodies for EP300 (p300)
    Cell Signaling Technology (CST) Antibodies for EP300  (p300)
    OriGene Antibodies for EP300
    OriGene Custom Antibody Services for EP300
    GenScript Custom Superior Antibodies Services for EP300
    Novus Biologicals EP300 Antibodies
    Abcam antibodies for EP300
    Cloud-Clone Corp. Antibodies for EP300 
    ThermoFisher Antibody for EP300
    LSBio Antibodies in human, mouse, rat for EP300 

    Assay Products for EP300: 
    EMD Millipore Kits and Assays for the Analysis of EP300
    OriGene Custom Assay Services for EP300
    R&D Systems Transcription Factor Binding & Immunoprecipitation Assays for EP300 (p300)
    GenScript Custom Assay Services for EP300
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EP300 
    Cloud-Clone Corp. CLIAs for EP300


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    KAT: Chromatin-modifying enzymes / K-acetyltransferases

    5/9 InterPro protein domains (see all 9):
     IPR010303 DUF902_CREBbp
     IPR009110 Nuc_rcpt_coact
     IPR018359 Bromodomain_CS
     IPR001487 Bromodomain
     IPR003101 KIX_dom

    Graphical View of Domain Structure for InterPro Entry Q09472

    ProtoNet protein and cluster: Q09472

    5 Blocks protein domains:
    IPB000197 TAZ finger
    IPB000433 Zn-finger
    IPB001487 Bromodomain signature
    IPB003101 Coactivator CBP
    IPB009255 Transcriptional coactivation


    UniProtKB/Swiss-Prot: EP300_HUMAN, Q09472
    Domain: The CRD1 domain (cell cycle regulatory domain 1) mediates transcriptional repression of a subset of p300
    responsive genes; it can be de-repressed by CDKN1A/p21WAF1 at least at some promoters. It conatins sumoylation
    and acetylation sites and the same lysine residues may be targeted for the respective modifications. It is
    proposed that deacetylation by SIRT1 allows sumoylation leading to suppressed activity
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 KIX domain
    Similarity: Contains 2 TAZ-type zinc fingers
    Similarity: Contains 1 ZZ-type zinc finger


    EP300 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EP300_HUMAN, Q09472
    Function: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates
    all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional
    activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions
    as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the
    presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53
    through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its
    inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence
    of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and
    controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement.
    Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the
    adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's
    transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and
    enhances its transcriptional activity
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

         Genatlas biochemistry entry for EP300:
    cellular protein p300,component with CREBBP of a coactivator complex connecting the basal transcriptional
    machinery to various DNA binding factors,i.e. binding the promoter of FTH1 and contributing to its tissue
    specific expression,target of adenoviral E1A oncoprotein,structurally and putatively preventing the G0/G1
    transition in cell cycle,also acting as an histone acetyltransferase for the four core histones in
    nucleosome,involved in acute myeloid leukemia with translocation t(11;22)(q23;q13)

         Enzyme Numbers (IUBMB): EC 2.3.1.481 2 EC 2.3.12

         Gene Ontology (GO): 5/19 molecular function terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001047core promoter binding IDA17641689
    GO:0001085RNA polymerase II transcription factor binding ----
    GO:0001102RNA polymerase II activating transcription factor binding IPI--
    GO:0002039p53 binding IEA--
    GO:0003677DNA binding IDA9194565
         
    EP300 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for EP300:
     Decreased G3BP1 protein expres  Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 
     Increased G1 DNA content 

         15/16 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Ep300) (see all 16):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     muscle  nervous system  renal/urinary system  respiratory system  tumorigenesis 

    EP300 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ep300tm1Dli for EP300

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EP300 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EP300

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EP300 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EP300 

    10/539 SABiosciences Target genes for EP300 (see all 539):
    ABCG4 ABHD1 ABHD13 ACSL5 ACSS1 ACTR6 ACTRT2 ACVR2B ADAM33 AGBL5

    miRNA
    Products:
        
    miRTarBase miRNAs that target EP300:
    hsa-mir-429 (MIRT003600), hsa-mir-194 (MIRT003603), hsa-mir-200b (MIRT003599), hsa-mir-200c (MIRT003598), hsa-mir-374a (MIRT004566), hsa-mir-182 (MIRT003601), hsa-mir-26b (MIRT003604)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EP300
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate EP300 (see all 55):
    hsa-miR-548j hsa-miR-429 hsa-miR-1245 hsa-miR-574-3p hsa-miR-624 hsa-miR-342-3p hsa-miR-29b-1* hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidEP300 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EP300
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EP300

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EP300


    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for EP300 (see all 5)
    OriGene ORF clones in mouse, rat for EP300
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EP300 (NM_001429)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EP300
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EP300

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EP300
    Search LifeMap BioReagents cell lines for EP300
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EP300


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EP300 About   (see all 110)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Immune response IFN gamma signaling pathway
    Immune response IFN gamma signaling pathway0.43
    IFN-gamma pathway0.43
    3Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    4Glioma
    Prostate cancer0.39
    Signaling Pathways in Glioblastoma0.36
    5Notch signaling pathway
    Notch signaling pathway0.84
    Delta-Notch Signaling Pathway0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/18 EMD Millipore Pathways for EP300 (see all 18)
        Transcription Androgen Receptor nuclear signaling
    Immune response MIF in innate immunity response
    Development TGF-beta receptor signaling
    Development Ligand-independent activation of ESR1 and ESR2
    Immune response Function of MEF2 in T lymphocytes

    2 R&D Systems Pathways for EP300
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways
    Notch Signaling Pathways

    5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EP300 (see all 33)
        Nuclear Receptor Activation by Vitamin-A
    Calcium Mediated T-Cell Apoptosis
    LT-BetaR Pathway
    Nur77 Signaling in T-Cell
    Androgen Signaling

    2 Cell Signaling Technology (CST) Pathways for EP300
        Chromatin Regulation / Acetylation
    Angiogenesis

    5/18 GeneGo (Thomson Reuters) Pathways for EP300 (see all 18)
        Immune response MIF in innate immunity response
    Transcription P53 signaling pathway
    Development TGF-beta receptor signaling
    Transcription Sin3 and NuRD in transcription regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation

    5/39 BioSystems Pathways for EP300 (see all 39)
        TGF Beta Signaling Pathway
    Cell cycle
    Wnt Signaling Pathway and Pluripotency
    SIDS Susceptibility Pathways
    Integrated Breast Cancer Pathway

    5/29        Reactome Pathways for EP300 (see all 29)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    Developmental Biology
    LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
    Transcriptional Regulation of White Adipocyte Differentiation


    5/21         Kegg Pathways  (Kegg details for EP300) (see all 21):
        HIF-1 signaling pathway
    Cell cycle
    Wnt signaling pathway
    Notch signaling pathway
    TGF-beta signaling pathway


    EP300 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EP300

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/668 Interacting proteins for EP300 (Q094721, 2, 3 ENSP000002632534) via UniProtKB, MINT, STRING, and/or I2D (see all 668)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIF1AQ166651, 2, 3, ENSP000003380184EBI-447295,EBI-447269 MINT-6802121 MINT-7943730 MINT-7943746 MINT-4791660 MINT-4791678 MINT-6802156 MINT-4652938 MINT-4791632 I2D: score=7 STRING: ENSP00000338018
    TP53P046371, 2, 3, ENSP000002693054EBI-447295,EBI-366083 MINT-69507 MINT-8152513 MINT-8152530 MINT-8392126 MINT-2830826 MINT-7263630 MINT-8152544 MINT-6628507 I2D: score=7 STRING: ENSP00000269305
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST4H4P628053, ENSP000003507674I2D: score=2 STRING: ENSP00000350767
    HIST1H4BP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA10733570
    GO:0001666response to hypoxia IDA15261140
    GO:0001756somitogenesis IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA15261140

    EP300 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EP300 for compounds           About GeneDecksing

    EMD Millipore small molecules for EP300:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for EP300

    Browse Tocris compounds for EP300

    3 HMDB Compounds for EP300    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    10/59 Novoseek inferred chemical compound relationships for EP300 gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    helenalin 62.3 1 19717552 (1)
    lysine 57.4 39 18753126 (3), 18655826 (3), 11279135 (2), 19949111 (2) (see all 27)
    polypropylene glycol 50.9 6 17486071 (2), 8290250 (1), 15220443 (1), 16862175 (1)
    retinoic acid 48.5 50 16581781 (5), 7628451 (5), 10780452 (3), 10475063 (3) (see all 21)
    curcumin 45.8 17 16638200 (4), 16787365 (3), 17927689 (2), 18227124 (1) (see all 9)
    retinoid 43.8 8 12205093 (1), 15731352 (1), 12646247 (1), 11641790 (1) (see all 6)
    steroid 43.5 35 12456802 (3), 12697832 (2), 12586842 (2), 12656669 (1) (see all 24)
    estrogen 43.2 24 11010967 (2), 10567538 (2), 19188451 (2), 9450928 (1) (see all 18)
    ly294002 36.8 4 15224190 (1), 20333651 (1), 12808085 (1), 17299794 (1)
    butyrate 35.7 8 10899165 (3), 12456802 (2), 12840224 (1), 10207071 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about EP300

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EP300 gene: 
    NM_001429.3  

    Unigene Cluster for EP300:

    E1A binding protein p300
    Hs.517517  [show with all ESTs]
    Unigene Representative Sequence: U01877
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000263253(uc003azl.4)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate EP300 (see all 55):
    hsa-miR-548j hsa-miR-429 hsa-miR-1245 hsa-miR-574-3p hsa-miR-624 hsa-miR-342-3p hsa-miR-29b-1* hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidEP300 3' UTR sequence
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    Additional mRNA sequence: 

    AK125679.1 BC053889.1 U01877.1 

    14 DOTS entries:

    DT.317177  DT.120670575  DT.75185151  DT.305170  DT.40110251  DT.92047060  DT.92436790  DT.95250753 
    DT.317172  DT.40306607  DT.92412601  DT.95206497  DT.120670582  DT.75165804 

    24/283 AceView cDNA sequences (see all 283):

    AA236852 BQ334732 NM_001429 BQ432084 BQ431464 BU677921 CB155618 AA371383 
    AI079333 AW662556 AK125679 BQ881188 BI029208 BM905974 BF895883 BU169989 
    BQ070795 H55463 AW172862 BQ054587 AA234896 AI609739 N58429 AI860087 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EP300 expression in normal human tissues (normalized intensities)      EP300 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EP300 Expression
    About this image


    EP300 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             bone marrow cd34+   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             seminal vesicle ; glandular cells   

    See EP300 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EP300

    SOURCE GeneReport for Unigene cluster: Hs.517517
        SABiosciences Expression via Pathway-Focused PCR Arrays including EP300 (see all 15): 
              Neurogenesis in human mouse rat
              HIV Host Response in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EP300 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ep3001 , 5 E1A binding protein p3001, 5 89.83(n)1
    94.26(a)1
      15 (38.16 cM)5
    3285721  NM_177821.61  NP_808489.41 
     815862145 
    chicken
    (Gallus gallus)
    Aves EP3001 E1A binding protein p300 81(n)
    86.4(a)
      418000  XM_001233887.2  XP_001233888.2 
    lizard
    (Anolis carolinensis)
    Reptilia EP3006
    E1A binding protein p300
    81(a)
    1 ↔ 1
    5(26109584-26191087)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.108122 Transcribed sequence with moderate similarity to protein more 79.73(n)    142024812 
    zebrafish
    (Danio rerio)
    Actinopterygii ep300b1 E1A binding protein p300 b 62.94(n)
    66.13(a)
      565612  XM_003198098.1  XP_003198146.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nej1 , 3 synaptic vesicle transport
    transcription co-activator3
    nejire1
    59(a)3
    50.74(n)1
    46.46(a)1
      438561  NM_001201647.11  NP_001188576.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F40F12.73
    cbp-11
    Protein CBP-11 62(a)3
    49.75(n)1
    44.27(a)1
      III(9986290-9987354)3
    1763801  NM_066760.41  NP_499161.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BDF26
    BDF16
    Protein involved in transcription initiation at TA...
    Protein involved in transcription initiation at TA...
    13(a)
    12(a)
    many ↔ many
    many ↔ many
    IV(331024-332940)
    XII(919536-921596)
    rice
    (Oryza sativa)
    Liliopsida Os.151222 Oryza sativa (japonica cultivar-group) putative CREB-binding more 73.51(n)    NM_188761.1 


    ENSEMBL Gene Tree for EP300 (if available)
    TreeFam Gene Tree for EP300 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EP300 gene
    BRDT2  BRD42  CREBBP2  BRD22  BRD32  
    6 SIMAP similar genes for EP300 using alignment to 2 protein entries:     EP300_HUMAN (see all proteins):
    CREBBP    CBP    CREB-binding protein    MORF/CBP    MOZ/CBP    BRDT

    EP300 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2278 SNPs in EP300 are shown (see all 2278)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0144294
    A breast cancer sample4--see VAR_0144292 E G mis40--------
    VAR_0144304
    A pancreatic cancer sample4--see VAR_0144302 S Y mis40--------
    VAR_0144284
    A breast cancer sample4--see VAR_0144282 L P mis40--------
    rs289375781,2,4
    CA colorectal cancer sample4 other125489250(+) CCCACA/CACAGC 2 Q P mis1 ese30--------
    rs676965351,2
    C--24455629(+) GTAAT-/T/TTT 
            
    TTTTT
    2 -- int1 cds10--------
    rs350555511,2
    C,F--24464363(+) AAGATC/-CCATG 1 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs1461497591,2
    C--24473547(+) GGATT-/C/CC  
            
    CCACC
    1 -- int10--------
    rs105291101,2
    C--24473550(+) ttcCA-/C/CC/ 
    CCC
    /CCCC
    CCCCC
    2 -- int1 cds1 trp31NA 2
    rs348681211,2
    C--24479192(+) AGGGG-/A/A   
       A
    /AAA
    AAAAA
    2 -- int1 cds10--------
    rs2015717301,2
    --24479201(+) AAAAA-/AAAAG 
            
    AACCT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for EP300 (41487790 - 41576081 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for EP300:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3636CNV Insertion18451855
    nsv915116CNV Loss21882294
    nsv524585CNV Loss19592680


    Human Gene Mutation Database (HGMD): EP300

    Locus Specific Mutation Databases (LSDB): EP300
    2 SABiosciences Cancer Mutation PCR Assays for EP300:
    Cosmic IdAA Change
    97816p.C1385F
    88777p.S507G
    SeqTarget long-range PCR primers for resequencing EP300
    DNA2.0 Custom Variant and Variant Library Synthesis for EP300

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602700   
    OMIM disorders: 114500  613684  
    UniProtKB/Swiss-Prot: EP300_HUMAN, Q09472
  • Note=Defects in EP300 may play a role in epithelial cancer
  • Note=Chromosomal aberrations involving EP300 may be a cause of acute myeloid leukemias. Translocation
    t(8;22)(p11;q13) with KAT6A
  • Rubinstein-Taybi syndrome 2 (RSTS2) [MIM:613684]: A disorder characterized by craniofacial abnormalities,
    postnatal growth deficiency, broad thumbs, broad big toes, mental retardation and a propensity for development of
    malignancies. Some individuals with RSTS2 have less severe mental impairment, more severe microcephaly, and a
    greater degree of changes in facial bone structure than RSTS1 patients. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 20/90 diseases for EP300 (see all 90):    About MalaCards
    mn1    ep300-related rubinstein-taybi syndrome    rubinstein-taybi syndrome 2    rubinstein-taybi syndrome
    neonatal leukemia    rothmund-thomson syndrome    hypoxia    acute monocytic leukemia
    prosopagnosia    acute myeloid leukemia with t translocation    weaver syndrome    monocytic leukemia
    craniofacial abnormalities    sotos syndrome    ewing's family of tumors    hepatic encephalopathy
    hepatitis e    tauopathy    short stature    myelofibrosis

    1 disease from the University of Copenhagen DISEASES database for EP300:
    Rubinstein-Taybi syndrome

    EP300 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/57 Novoseek inferred disease relationships for EP300 gene (see all 57)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rubinstein-taybi syndrome 81.3 13 17299436 (2), 19353645 (2), 11962765 (1), 15706485 (1) (see all 10)
    leukemia t-cell 60.5 6 11264182 (1), 18815299 (1), 10744749 (1), 9528808 (1) (see all 5)
    retinoblastoma 53.4 21 8331729 (2), 2143024 (1), 7523245 (1), 15741165 (1) (see all 17)
    leukemogenesis 51.4 8 18695000 (2), 18809579 (1), 10824998 (1), 15312679 (1) (see all 7)
    promyelocytic leukemia 44 2 10893273 (1), 15964811 (1)
    tumors 43.8 76 18459105 (4), 20097195 (3), 17725108 (3), 19047049 (3) (see all 52)
    cancer 30.7 42 12696060 (6), 10700188 (4), 14732695 (3), 17965222 (2) (see all 20)
    prostate cancer 29.1 31 17409453 (5), 15705864 (4), 15994976 (4), 10344722 (3) (see all 15)
    mental retardation 25.3 1 17299436 (1)
    breast cancer 22.2 12 16867872 (5), 20097195 (2), 19183483 (1), 16928824 (1) (see all 6)

    GeneTests: EP300
    GeneReviews: EP300
    Genetic Association Database (GAD): EP300
    Human Genome Epidemiology (HuGE) Navigator: EP300 (15 documents)

    Export disorders for EP300 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EP300 gene, integrated from 9 sources (see all 1267):
    (articles sorted by number of sources associating them with EP300)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional analysis of the adenovirus E1A- associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. (PubMed id 7523245)1, 2, 3, 9 Eckner R.... Livingston D.M. (1994)
    2. Acetylation of Sirt2 by p300 attenuates its deacetylase activity. (PubMed id 18722353)1, 2, 9 Han Y....Lee K.Y. (2008)
    3. A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation. (PubMed id 10733570)1, 2, 9 Snowden A.W....Perkins N.D. (2000)
    4. HIV-1 tat transcriptional activity is regulated by acetylation. (PubMed id 10545121)1, 2, 9 Kiernan R.E....Van Lint C. (1999)
    5. Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300. (PubMed id 9528808)1, 2, 9 Bex F.... Gaynor R.B. (1998)
    6. Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation. (PubMed id 19217391)1, 2, 9 Feng H.... Bai Y. (2009)
    7. Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86. (PubMed id 15075319)1, 2, 9 Wang H.... Oettgen P. (2004)
    8. Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53. (PubMed id 15509808)1, 2, 9 Dornan D....Ball K.L. (2004)
    9. Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. (PubMed id 15186775)1, 2, 9 An W.... Roeder R.G. (2004)
    10. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. (PubMed id 12750254)1, 2, 9 Shiseki M....Harris C.C. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2033 HGNC: 3373 AceView: EP300 Ensembl:ENSG00000100393 euGenes: HUgn2033
    ECgene: EP300 Kegg: 2033 H-InvDB: EP300

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EP300 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EP300 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/EP300
    Wikipedia http://en.wikipedia.org/wiki/P300/CBP

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EP300 gene:
    Search GeneIP for patents involving EP300

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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