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EP300 Gene

protein-coding   GIFtS: 73
GCID: GC22P041487

E1A Binding Protein P300

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
E1A Binding Protein P3001 2     KAT3B2
Histone Acetyltransferase P3001 2     E1A-Binding Protein, 300kD2
E1A-Associated Protein P3002 3     p3002
P300 HAT2 3     P3003
EC 2.3.1.483 8     EC 2.3.18
RSTS22 5     

External Ids:    HGNC: 33731   Entrez Gene: 20332   Ensembl: ENSG000001003937   OMIM: 6027005   UniProtKB: Q094723   

Export aliases for EP300 gene to outside databases

Previous GC identifers: GC22P038102 GC22P039730 GC22P039812 GC22P024453


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EP300 Gene:
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions
as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the
processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to
phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible
factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this
gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. (provided by RefSeq,
Jul 2008)

GeneCards Summary for EP300 Gene:
EP300 (E1A binding protein p300) is a protein-coding gene. Diseases associated with EP300 include ep300-related rubinstein-taybi syndrome, and rubinstein-taybi syndrome 2. GO annotations related to this gene include transcription coactivator activity and chromatin binding. An important paralog of this gene is BRDT.

UniProtKB/Swiss-Prot: EP300_HUMAN, Q09472
Function: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates
all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional
activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates
acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone
octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of
histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates
'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to
indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2
deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a
TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of
NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in
the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression.
Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1
infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help
inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity.
Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional
repressor activity

Gene Wiki entry for EP300 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EP300 gene promoter:
         MEF-2A   PPAR-alpha   AP-1   ATF-2   c-Jun   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): EP300 promoter sequence
   Search Chromatin IP Primers for EP300

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EP300


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

EP300 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EP300 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P041487:  view genomic region     (about GC identifiers)

Start:
41,487,790 bp from pter      End:
41,576,081 bp from pter
Size:
88,292 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EP300_HUMAN, Q09472 (See protein sequence)
Recommended Name: Histone acetyltransferase p300  
Size: 2414 amino acids; 264161 Da
Subunit: Interacts with phosphorylated CREB1 (By similarity). Interacts with HIF1A; the interaction is stimulated
in response to hypoxia and inhibited by CITED2. Interacts (via N-terminus) with TFAP2A (via N-terminus); the
interaction requires CITED2. Interacts (via CH1 domain) with CITED2 (via C-terminus). Interacts with CITED1
(unphosphorylated form preferentially and via C-terminus). Interacts with ESR1; the interaction is
estrogen-dependent and enhanced by CITED1. Interacts with DTX1, EID1, ELF3, FEN1, LEF1, NCOA1, NCOA6, NR3C1,
PCAF, PELP1, PRDM6, SP1, SP3, SPIB, SRY, TCF7L2, TP53, DDX5, DDX17, SATB1, SRCAP, TTC5, JMY and TRERF1. The
TAZ-type 1 domain interacts with HIF1A. Probably part of a complex with HIF1A and CREBBP. Part of a complex
containing CARM1 and NCOA2/GRIP1. Interacts with ING4 and this interaction may be indirect. Interacts with ING5.
Interacts with the C-terminal region of CITED4. Interacts with HTLV-1 Tax and p30II. Interacts with and
acetylates HIV-1 Tat. Non-sumoylated EP300 preferentially interacts with SENP3. Interacts with SS18L1/CREST.
Interacts with ALX1 (via homeobox domain). Interacts with NEUROD1; the interaction is inhibited by NR0B2.
Interacts with TCF3. Interacts (via CREB-binding domain) with MYOCD (via C-terminus) (By similarity). Binds to
HIPK2 (By similarity). Interacts with ROCK2 and PPARG. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and
GATA4 that stimulates hypertrophy in cardiomyocytes. Interacts with IRF1 and this interaction enhances
acetylation of p53/TP53 and stimulation of its activity. Interacts with FOXO1; the interaction acetylates FOXO1
and enhances its transcriptional activity. Interacts with ALKBH4 and DDIT3/CHOP. Interacts with KLF15
Selected PDB 3D structures from and Proteopedia for EP300 (see all 9):
1L3E (3D)        1P4Q (3D)        2K8F (3D)        3BIY (3D)        3I3J (3D)        3IO2 (3D)    
Secondary accessions: B1AKC2

Explore the universe of human proteins at neXtProt for EP300: NX_Q09472

Explore proteomics data for EP300 at MOPED

Post-translational modifications: 

  • Acetylated on Lys at up to 17 positions by intermolecular autocatalysis. Deacetylated in the transcriptional
    repression domain (CRD1) by SIRT1, preferentially at Lys-10201
  • Citrullinated at Arg-2142 by PADI4, which impairs methylation by CARM1 and promotes interaction with NCOA2/GRIP11
  • Methylated at Arg-580 and Arg-604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB
    signaling and activates apoptotic response. Also methylated at Arg-2142 by CARM1, which impairs interaction with
    NCOA2/GRIP11
  • Sumoylated; sumoylation in the transcriptional repression domain (CRD1) mediates transcriptional repression.
    Desumoylated by SENP3 through the removal of SUMO2 and SUMO31
  • Probable target of ubiquitination by FBXO3, leading to rapid proteasome-dependent degradation1
  • Phosphorylated by HIPK2 in a RUNX1-dependent manner. This phosphorylation that activates EP300 happens when RUNX1
    is associated with DNA and CBFB. Phosphorylated by ROCK2 and this enhances its activity. Phosphorylation at
    Ser-89 by AMPK reduces interaction with nuclear receptors, such as PPARG1
  • Ubiquitination2 at Lys1637
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for EP300 (Q09472)
     PTPHHTP  LIGYLEY  PNQRRVY  VYHEILIGYL 


    See EP300 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001420.2  
    ENSEMBL proteins: 
     ENSP00000263253  
    Reactome Protein details: Q09472

    EP300 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant EP300 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for EP300
    OriGene Purified Protein for EP300
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for EP300
    OriGene Custom Protein Services for EP300
    GenScript Custom Purified and Recombinant Proteins Services for EP300
    Novus Biologicals EP300 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EP300

    EP300 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of EP300
    R&D Systems Antibodies for EP300 (p300)
    Cell Signaling Technology (CST) Antibodies for EP300  (p300)
    OriGene Antibodies for EP300
    OriGene Custom Antibody Services for EP300
    Novus Biologicals EP300 Antibodies
    Abcam antibodies for EP300
    Cloud-Clone Corp. Antibodies for EP300
    ThermoFisher Antibody for EP300
    LSBio Antibodies in human, mouse, rat for EP300

    EP300 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of EP300
    OriGene Custom Assay Services for EP300
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EP300
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EP300
    Cloud-Clone Corp. CLIAs for EP300


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KAT: Chromatin-modifying enzymes / K-acetyltransferases

    Selected InterPro protein domains (see all 9):
     IPR010303 DUF902_CREBbp
     IPR009110 Nuc_rcpt_coact
     IPR018359 Bromodomain_CS
     IPR001487 Bromodomain
     IPR003101 KIX_dom

    Graphical View of Domain Structure for InterPro Entry Q09472

    ProtoNet protein and cluster: Q09472

    5 Blocks protein domains:
    IPB000197 TAZ finger
    IPB000433 Zn-finger
    IPB001487 Bromodomain signature
    IPB003101 Coactivator CBP
    IPB009255 Transcriptional coactivation


    UniProtKB/Swiss-Prot: EP300_HUMAN, Q09472
    Domain: The CRD1 domain (cell cycle regulatory domain 1) mediates transcriptional repression of a subset of p300
    responsive genes; it can be de-repressed by CDKN1A/p21WAF1 at least at some promoters. It conatins sumoylation
    and acetylation sites and the same lysine residues may be targeted for the respective modifications. It is
    proposed that deacetylation by SIRT1 allows sumoylation leading to suppressed activity
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 KIX domain
    Similarity: Contains 2 TAZ-type zinc fingers
    Similarity: Contains 1 ZZ-type zinc finger


    EP300 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EP300_HUMAN, Q09472
    Function: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates
    all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional
    activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates
    acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone
    octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of
    histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates
    'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to
    indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2
    deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a
    TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of
    NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in
    the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression.
    Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1
    infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help
    inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity.
    Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional
    repressor activity
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

         Genatlas biochemistry entry for EP300:
    cellular protein p300,component with CREBBP of a coactivator complex connecting the basal transcriptional
    machinery to various DNA binding factors,i.e. binding the promoter of FTH1 and contributing to its tissue
    specific expression,target of adenoviral E1A oncoprotein,structurally and putatively preventing the G0/G1
    transition in cell cycle,also acting as an histone acetyltransferase for the four core histones in
    nucleosome,involved in acute myeloid leukemia with translocation t(11;22)(q23;q13)

         Enzyme Numbers (IUBMB): EC 2.3.1.481 2 EC 2.3.12

         Gene Ontology (GO): Selected molecular function terms (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA--
    GO:0001047core promoter binding IDA17641689
    GO:0001085RNA polymerase II transcription factor binding ----
    GO:0001102RNA polymerase II activating transcription factor binding IPI--
    GO:0001159core promoter proximal region DNA binding ----
         
    EP300 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for EP300:
     Decreased G3BP1 protein expres  Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 
     Increased G1 DNA content 

         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Ep300) (see all 16):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     muscle  nervous system  renal/urinary system  respiratory system  tumorigenesis 

    EP300 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ep300tm1Dli for EP300

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EP300
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EP300

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EP300
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EP300

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for EP300 (see all 534):
    ABCG4,  ABHD1,  ABHD13,  ACSL5,  ACSS1,  ACTR6,  ACTRT2,  ACVR2B,  ADAM33,  AGBL5

    miRNA
    Products:
        
    miRTarBase miRNAs that target EP300:
    hsa-mir-25-3p (MIRT050220), hsa-mir-194-5p (MIRT003603), hsa-mir-200b-3p (MIRT003599), hsa-mir-181b-5p (MIRT047254), hsa-mir-30c-5p (MIRT047948), hsa-mir-149-5p (MIRT045469), hsa-mir-9-5p (MIRT021346), hsa-mir-23b-3p (MIRT046334), hsa-mir-181d-5p (MIRT041181), hsa-mir-26b-5p (MIRT003604), hsa-mir-140-5p (MIRT045823), hsa-mir-429 (MIRT003600), hsa-mir-30a-3p (MIRT049923), hsa-mir-92a-3p (MIRT049743), hsa-mir-374a-5p (MIRT004566), hsa-mir-182-5p (MIRT003601), hsa-mir-615-3p (MIRT039708), hsa-mir-130b-5p (MIRT038305), hsa-let-7b-5p (MIRT051995), hsa-mir-200c-3p (MIRT003598), hsa-mir-193b-3p (MIRT041490), hsa-mir-150-5p (MIRT007087)

    Block miRNA regulation of human, mouse, rat EP300 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EP300 (see all 55):
    hsa-miR-548j hsa-miR-429 hsa-miR-1245 hsa-miR-574-3p hsa-miR-624 hsa-miR-342-3p hsa-miR-29b-1* hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidEP300 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EP300
    Predesigned siRNA for gene silencing in human, mouse, rat EP300

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EP300

    Clone
    Products:
         
    OriGene clones in human, mouse for EP300 (see all 5)
    OriGene ORF clones in mouse, rat for EP300
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EP300 (NM_001429)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EP300
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EP300

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EP300
    Browse ESI BIO Cell Lines and PureStem Progenitors for EP300 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EP300


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EP300_HUMAN, Q09472: Cytoplasm. Nucleus. Note=In the presence of ALX1 relocalizes from the cytoplasm to the
    nucleus. Colocalizes with ROCK2 in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000123histone acetyltransferase complex IEA--
    GO:0000785chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--

    EP300 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EP300 About   (see all 117)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Immune response IFN gamma signaling pathway
    IFN-gamma pathway0.43
    Immune response IFN gamma signaling pathway0.43
    3Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    4Glioma
    Prostate cancer0.39
    Signaling Pathways in Glioblastoma0.36
    5Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Delta-Notch Signaling Pathway0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for EP300
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways
    Notch Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EP300 (see all 33)
        Nuclear Receptor Activation by Vitamin-A
    Calcium Mediated T-Cell Apoptosis
    LT-BetaR Pathway
    Nur77 Signaling in T-Cell
    Androgen Signaling

    2 Cell Signaling Technology (CST) Pathways for EP300
        Chromatin Regulation / Acetylation
    Angiogenesis

    Selected GeneGo (Thomson Reuters) Pathways for EP300 (see all 18)
        Immune response MIF in innate immunity response
    Transcription P53 signaling pathway
    Development TGF-beta receptor signaling
    Transcription Sin3 and NuRD in transcription regulation
    Development NOTCH1-mediated pathway for NF-KB activity modulation

    Selected BioSystems Pathways for EP300 (see all 39)
        Cell cycle
    TGF Beta Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    SIDS Susceptibility Pathways
    Integrated Breast Cancer Pathway

    Selected Reactome Pathways for EP300 (see all 20)
        NOTCH1 Intracellular Domain Regulates Transcription
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    Transcriptional regulation of white adipocyte differentiation
    HATs acetylate histones
    LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production


    Selected Kegg Pathways  (Kegg details for EP300) (see all 23):
        HIF-1 signaling pathway
    FoxO signaling pathway
    Cell cycle
    Wnt signaling pathway
    Notch signaling pathway


    EP300 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EP300 (see all 15): 
              Neurogenesis in human mouse rat
              HIV Host Response in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EP300

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EP300 (Q094721, 2, 3 ENSP000002632534) via UniProtKB, MINT, STRING, and/or I2D (see all 729)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIF1AQ166651, 2, 3, ENSP000003380184EBI-447295,EBI-447269 MINT-6802121 MINT-7943730 MINT-7943746 MINT-4791678 MINT-4791660 MINT-6802156 MINT-4652938 MINT-4791632 I2D: score=7 STRING: ENSP00000338018
    TP53P046371, 2, 3, ENSP000002693054EBI-447295,EBI-366083 MINT-69507 MINT-8152513 MINT-8152530 MINT-8392126 MINT-2830826 MINT-7263630 MINT-6628507 MINT-8152544 I2D: score=7 STRING: ENSP00000269305
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST4H4P628053, ENSP000003507674I2D: score=2 STRING: ENSP00000350767
    HIST1H4BP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 70):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA10733570
    GO:0000278mitotic cell cycle TAS--
    GO:0001666response to hypoxia IDA15261140
    GO:0001756somitogenesis IEA--

    EP300 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for EP300
      Browse compounds at ApexBio 

    Browse Tocris compounds for EP300

    3 HMDB Compounds for EP300    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    Selected Novoseek inferred chemical compound relationships for EP300 gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    helenalin 62.3 1 19717552 (1)
    lysine 57.4 39 18753126 (3), 18655826 (3), 11279135 (2), 19949111 (2) (see all 27)
    polypropylene glycol 50.9 6 17486071 (2), 8290250 (1), 15220443 (1), 16862175 (1)
    retinoic acid 48.5 50 16581781 (5), 7628451 (5), 10780452 (3), 10475063 (3) (see all 21)
    curcumin 45.8 17 16638200 (4), 16787365 (3), 17927689 (2), 18227124 (1) (see all 9)
    retinoid 43.8 8 12205093 (1), 15731352 (1), 12646247 (1), 11641790 (1) (see all 6)
    steroid 43.5 35 12456802 (3), 12697832 (2), 12586842 (2), 12656669 (1) (see all 24)
    estrogen 43.2 24 11010967 (2), 10567538 (2), 19188451 (2), 9450928 (1) (see all 18)
    ly294002 36.8 4 15224190 (1), 20333651 (1), 12808085 (1), 17299794 (1)
    butyrate 35.7 8 10899165 (3), 12456802 (2), 12840224 (1), 10207071 (1) (see all 5)



    EP300 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for EP300 gene: 
    NM_001429.3  

    Unigene Cluster for EP300:

    E1A binding protein p300
    Hs.517517  [show with all ESTs]
    Unigene Representative Sequence: U01877
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000263253(uc003azl.4)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EP300 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EP300 (see all 55):
    hsa-miR-548j hsa-miR-429 hsa-miR-1245 hsa-miR-574-3p hsa-miR-624 hsa-miR-342-3p hsa-miR-29b-1* hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidEP300 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat EP300

    Additional mRNA sequence: 

    AK125679.1 BC053889.1 U01877.1 

    14 DOTS entries:

    DT.317177  DT.120670575  DT.75185151  DT.305170  DT.40110251  DT.92047060  DT.92436790  DT.95250753 
    DT.317172  DT.40306607  DT.92412601  DT.95206497  DT.120670582  DT.75165804 

    Selected AceView cDNA sequences (see all 283):

    BQ881188 AA371383 BU682772 BE351044 CB128649 BI051150 H55463 AI079333 
    AI339236 AI290302 BQ070795 BC053889 NM_001429 AA236852 AK125679 AW662556 
    BX098158 AI860087 BQ434736 BM836491 AA234896 BQ054587 BM905974 BG011505 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EP300 expression in normal human tissues (normalized intensities)      EP300 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EP300 Expression
    About this image


    EP300 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Bone (Muscoskeletal System)
             Bone Marrow
    EP300 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EP300 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517517
        Pathway & Disease-focused RT2 Profiler PCR Arrays including EP300 (see all 15): 
              Neurogenesis in human mouse rat
              HIV Host Response in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              WNT Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EP300

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EP300 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ep3001 , 5 E1A binding protein p3001, 5 89.26(n)1
    93.35(a)1
      15 (38.16 cM)5
    3285721  NM_177821.61  NP_808489.41 
     815862145 
    chicken
    (Gallus gallus)
    Aves EP3001 E1A binding protein p300 80.48(n)
    85.44(a)
      418000  XM_004937710.1  XP_004937767.1 
    lizard
    (Anolis carolinensis)
    Reptilia EP3006
    E1A binding protein p300
    81(a)
    1 ↔ 1
    5(26109584-26191087)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.108122 Transcribed sequence with moderate similarity to protein more 79.73(n)    142024812 
    zebrafish
    (Danio rerio)
    Actinopterygii ep300a1 E1A binding protein p300 a 72.9(n)
    81.57(a)
      559273  XM_005156176.1  XP_005156233.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nej3 synaptic vesicle transport
    transcription co-activator
    59(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea F40F12.73   -- 62(a)   III(9986290-9987354)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BDF16
    BDF26
    Protein involved in transcription initiation at TA...
    Protein involved in transcription initiation at TA...
    22(a)
    22(a)
    many ↔ many
    many ↔ many
    XII(919536-921596) YLR399C
    IV(331024-332940) YDL070W
    rice
    (Oryza sativa)
    Liliopsida Os.151222 Oryza sativa (japonica cultivar-group) putative CREB-binding more 73.51(n)    NM_188761.1 


    ENSEMBL Gene Tree for EP300 (if available)
    TreeFam Gene Tree for EP300 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for EP300 gene
    BRDT2  BRD42  CREBBP2  BRD22  BRD32  
    6 SIMAP similar genes for EP300 using alignment to 2 protein entries:     EP300_HUMAN (see all proteins):
    CREBBP    CBP    CREB-binding protein    MORF/CBP    MOZ/CBP    BRDT

    EP300 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EP300 (see all 2278)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289375781,2,,4
    CA colorectal cancer sample4 other125489250(+) CCCACA/CACAGC 2 Q P mis1 ese30--------
    VAR_0144294
    A breast cancer sample4--see VAR_0144292 E G mis40--------
    VAR_0144304
    A pancreatic cancer sample4--see VAR_0144302 S Y mis40--------
    VAR_0144284
    A breast cancer sample4--see VAR_0144282 L P mis40--------
    rs676965351,2
    C--24455629(+) GTAAT-/T/TTT 
            
    TTTTT
    2 -- int1 cds10--------
    rs350555511,2
    C,F--24464363(+) AAGATC/-CCATG 1 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs1461497591,2
    C--24473547(+) GGATT-/C/CC  
            
    CCACC
    1 -- int10--------
    rs105291101,2
    C--24473550(+) ttcCA-/C/CC/ 
    CCC
    /CCCC
    CCCCC
    2 -- int1 cds1 trp31NA 2
    rs348681211,2
    C--24479192(+) AGGGG-/A/A   
       A
    /AAA
    AAAAA
    2 -- int1 cds10--------
    rs2015717301,2
    --24479201(+) AAAAA-/AAAAG 
            
    AACCT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for EP300 (41487790 - 41576081 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for EP300:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3636CNV Insertion18451855
    nsv915116CNV Loss21882294
    nsv524585CNV Loss19592680

    Human Gene Mutation Database (HGMD): EP300
    Locus Specific Mutation Databases (LSDB): EP300

    2 Site Specific Mutation Identification with PCR Assays for EP300:
    Cosmic IdAA Change
    97816p.C1385F
    88777p.S507G
    SeqTarget long-range PCR primers for resequencing EP300
    DNA2.0 Custom Variant and Variant Library Synthesis for EP300

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602700   
    OMIM disorders: 613684  114500  
    UniProtKB/Swiss-Prot: EP300_HUMAN, Q09472
  • Note=Defects in EP300 may play a role in epithelial cancer
  • Note=Chromosomal aberrations involving EP300 may be a cause of acute myeloid leukemias. Translocation
    t(8;22)(p11;q13) with KAT6A
  • Rubinstein-Taybi syndrome 2 (RSTS2) [MIM:613684]: A disorder characterized by craniofacial abnormalities,
    postnatal growth deficiency, broad thumbs, broad big toes, mental retardation and a propensity for development of
    malignancies. Some individuals with RSTS2 have less severe mental impairment, more severe microcephaly, and a
    greater degree of changes in facial bone structure than RSTS1 patients. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for EP300 (see all 102):    About MalaCards
    ep300-related rubinstein-taybi syndrome    rubinstein-taybi syndrome 2    rubinstein-taybi syndrome    neonatal leukemia
    acute monocytic leukemia    rothmund-thomson syndrome    hypoxia    prosopagnosia
    mn1    monocytic leukemia    weaver syndrome    colorectal cancer, somatic
    ewing's family of tumors    sotos syndrome    hepatic encephalopathy    hepatitis e
    acute myeloid leukemia    tauopathy    cockayne syndrome    short stature

    1 disease from the University of Copenhagen DISEASES database for EP300:
    Rubinstein-Taybi syndrome

    EP300 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for EP300 gene (see all 57)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rubinstein-taybi syndrome 81.3 13 17299436 (2), 19353645 (2), 11962765 (1), 15706485 (1) (see all 10)
    leukemia t-cell 60.5 6 11264182 (1), 18815299 (1), 10744749 (1), 9528808 (1) (see all 5)
    retinoblastoma 53.4 21 8331729 (2), 2143024 (1), 7523245 (1), 15741165 (1) (see all 17)
    leukemogenesis 51.4 8 18695000 (2), 18809579 (1), 10824998 (1), 15312679 (1) (see all 7)
    promyelocytic leukemia 44 2 10893273 (1), 15964811 (1)
    tumors 43.8 76 18459105 (4), 20097195 (3), 17725108 (3), 19047049 (3) (see all 52)
    cancer 30.7 42 12696060 (6), 10700188 (4), 14732695 (3), 17965222 (2) (see all 20)
    prostate cancer 29.1 31 17409453 (5), 15705864 (4), 15994976 (4), 10344722 (3) (see all 15)
    mental retardation 25.3 1 17299436 (1)
    breast cancer 22.2 12 16867872 (5), 20097195 (2), 19183483 (1), 16928824 (1) (see all 6)

    GeneTests: EP300
    GeneReviews: EP300
    Genetic Association Database (GAD): EP300
    Human Genome Epidemiology (HuGE) Navigator: EP300 (15 documents)

    Export disorders for EP300 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EP300 gene, integrated from 10 sources (see all 1287):
    (articles sorted by number of sources associating them with EP300)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional analysis of the adenovirus E1A- associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. (PubMed id 7523245)1, 2, 3, 9 Eckner R.... Livingston D.M. (Genes Dev. 1994)
    2. Acetylation of Sirt2 by p300 attenuates its deacetylase activity. (PubMed id 18722353)1, 2, 9 Han Y....Lee K.Y. (Biochem. Biophys. Res. Commun. 2008)
    3. A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation. (PubMed id 10733570)1, 2, 9 Snowden A.W.... Perkins N.D. (Mol. Cell. Biol. 2000)
    4. HIV-1 tat transcriptional activity is regulated by acetylation. (PubMed id 10545121)1, 2, 9 Kiernan R.E....Van Lint C. (EMBO J. 1999)
    5. Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300. (PubMed id 9528808)1, 2, 9 Bex F.... Gaynor R.B. (Mol. Cell. Biol. 1998)
    6. Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation. (PubMed id 19217391)1, 2, 9 Feng H.... Bai Y. (Structure 2009)
    7. Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86. (PubMed id 15075319)1, 2, 9 Wang H.... Oettgen P. (J. Biol. Chem. 2004)
    8. Interferon regulatory factor 1 binding to p300 stimulates DNA- dependent acetylation of p53. (PubMed id 15509808)1, 2, 9 Dornan D....Ball K.L. (Mol. Cell. Biol. 2004)
    9. Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. (PubMed id 15186775)1, 2, 9 An W.... Roeder R.G. (Cell 2004)
    10. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. (PubMed id 12750254)1, 2, 9 Shiseki M....Harris C.C. (Cancer Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2033 HGNC: 3373 AceView: EP300 Ensembl:ENSG00000100393 euGenes: HUgn2033
    ECgene: EP300 Kegg: 2033 H-InvDB: EP300

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EP300 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EP300 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=EP300[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/P300/CBP

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EP300 gene:
    Search GeneIP for patents involving EP300

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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