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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EOMES Gene

protein-coding   GIFtS: 59
GCID: GC03M027757

eomesodermin

(Previous name: eomesodermin (Xenopus laevis) homolog )
 Explore 10 diseases affiliated with
EOMES via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for EOMES    

Aliases
for EOMES gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Eomesodermin1     Eomesodermin (Xenopus Laevis) Homolog1
TBR21 2 3 5     Eomesodermin Homolog2
T-Brain-21     T Box, Brain, 22
TBR-22 3     T-Box Brain22
T-Box Brain Protein 22 3     

External Ids:    HGNC: 33721   Entrez Gene: 83202   Ensembl: ENSG000001635087   OMIM: 6046155   UniProtKB: O959363   

Export aliases for EOMES gene to outside databases

Previous GC identifers: GC03M027209 GC03M027607 GC03M027732 GC03M027700


Summaries
for EOMES gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EOMES:
This gene encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box
genes encode transcription factors involved in the regulation of developmental processes. A similiar gene disrupted in
mice is shown to be essential during trophoblast development and gastrulation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: EOMES_HUMAN, O95936
Function: Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast
differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a
role in brain development being required for the specification and the proliferation of the intermediate progenitor
cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune
response regulating the expression of lytic effector genes

Gene Wiki entry for EOMES (Eomesodermin)


Genomic Views
for EOMES gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EOMES gene promoter:
         STAT1   p53   AP-1   ATF-2   STAT1beta   c-Jun   Pax-4a   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EOMES promoter sequence
   Search SABiosciences Chromatin IP Primers for EOMES

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EOMES


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.1   Ensembl cytogenetic band:  3p24.1   HGNC cytogenetic band: 3p24.1

EOMES Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EOMES gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M027757:  view genomic region     (about GC identifiers)

Start:
 27,757,440 bp from pter      End:
 27,764,206 bp from pter
Size:
 6,767 bases      Orientation:
 minus strand

Proteins
for EOMES gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EOMES_HUMAN, O95936 (See protein sequence)
Recommended Name: Eomesodermin homolog  
Size: 686 amino acids; 72732 Da
Subcellular location: Nucleus (Probable)
Developmental stage: Detected at 7 weeks of development in the forebrain floorplate of the CNS. Expressed within the
mantle layer and migrating neuroblasts of the telencephalon at 12.5 weeks of development
Secondary accessions: B7Z4I2 Q8TAZ2 Q9UPM7
Alternative splicing: 2 isoforms:  O95936-1   O95936-2   

Explore the universe of human proteins at neXtProt for EOMES: NX_O95936

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95936

    • EOMES Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005433.2  
    ENSEMBL proteins: 
     ENSP00000295743   ENSP00000388620   ENSP00000442097  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: EOMES
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    Novus Biologicals EOMES Proteins
    Novus Biologicals EOMES Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EOMES

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--


    EOMES for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for EOMES

    Protein Domains /
    Families
    for EOMES gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EOMES for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001699 TF_T-box
     IPR008967 p53-like_TF_DNA-bd
     IPR018186 TF_T-box_CS

    Graphical View of Domain Structure for InterPro Entry O95936

    ProtoNet protein and cluster: O95936

    1 Blocks protein family: IPB001699 Transcription factor

    UniProtKB/Swiss-Prot: EOMES_HUMAN, O95936
    Similarity: Contains 1 T-box DNA-binding domain


    Function
    for EOMES gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EOMES_HUMAN, O95936
    Function: Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast
    differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a
    role in brain development being required for the specification and the proliferation of the intermediate progenitor
    cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune
    response regulating the expression of lytic effector genes
    Induction: Up-regulated in CD8+ T-cells simultaneously stimulated with TGFB1 and IL4/interleukin-4

         Genatlas biochemistry entry for EOMES:
    eomesodermin,expressed in forebrain and T lymphocyte (T,brachyury,TBR1 subfamily),involved in developmental regulation

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EOMES
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate EOMES (see all 22):
    hsa-miR-25 hsa-miR-1271 hsa-miR-3190 hsa-miR-103a hsa-miR-1184 hsa-miR-3613-3p hsa-miR-92b hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmid: EOMES 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EOMES (see all 4)
    OriGene shRNA RFP: EOMES
    OriGene siRNA: EOMES
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EOMES

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for EOMES

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EOMES (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: EOMES (NM_005442)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EOMES
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat EOMES 

    Cell Line
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    Search LifeMap BioReagents cell lines for EOMES

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EOMES

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IEA--
    GO:0001102RNA polymerase II activating transcription factor binding ISS--
    GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription ISS--
    GO:0003677DNA binding ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--


    EOMES for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for EOMES:
     Decreased Hepatitis C virus re 

    Animal Models:
         Mouse knock-outs for EOMES: Eomestm1.1Rob Eomestm1.1Whk Eomestm1Jrt
         13 MGI mutant phenotypes (inferred from 10 alleles) (MGI details for Eomes):
     behavior/neurological  cellular  embryogenesis  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  nervous system  no phenotypic analysis  normal 
     reproductive system  tumorigenesis  vision/eye 

    EOMES for phenotypes           About GeneDecksing


    Pathways & Interactions
    for EOMES gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Selected targets of Oct-3/4
    		Selected targets of Oct-3/41.00
    2Transcriptional Regulatory Network in Embryonic Stem Cell
    		Transcriptional Regulatory Network in Embryonic Stem Cell1.00
    3Downstream signaling in naive CD8+ T cells
    		Downstream signaling in naive CD8+ T cells1.00
    4Immune response IL-12-induced IFN-gamma production
    		IL12-mediated signaling events0.33

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for EOMES
        Selected targets of Oct-3/4

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for EOMES
        Transcriptional Regulatory Network in Embryonic Stem Cell

    2 BioSystems Pathways for EOMES 
        Downstream signaling in naive CD8+ T cells
    IL12-mediated signaling events



    EOMES for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EOMES

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/17 Interacting proteins for EOMES (O959362, 3 ENSP000002957434) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PFDN1O609252, 3MINT-8265808 I2D: score=2 
    CD247ENSP000003547824STRING: ENSP00000354782
    CD3DENSP000003006924STRING: ENSP00000300692
    CD3EENSP000003545664STRING: ENSP00000354566
    CD3GENSP000002921444STRING: ENSP00000292144
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001706endoderm formation ISS--
    GO:0001707mesoderm formation ISS--
    GO:0001714endodermal cell fate specification IEA--
    GO:0001824blastocyst development ----


    EOMES for ontologies           About GeneDecksing



    Drugs & Compounds
    for EOMES gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EOMES
    Search CenterWatch for drugs/clinical trials and news about EOMES 

    Transcripts
    for EOMES gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EOMES gene: 
    NM_005442.2  

    Unigene Cluster for EOMES:

    Eomesodermin
    Hs.591663  [show with all ESTs]
    Unigene Representative Sequence: BC037568
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295743(uc003cdx.3) ENST00000449599(uc003cdy.3 uc010hfn.2)
    ENST00000461503 ENST00000537516(uc011axc.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: EOMES
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EOMES
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate EOMES (see all 22):
    hsa-miR-25 hsa-miR-1271 hsa-miR-3190 hsa-miR-103a hsa-miR-1184 hsa-miR-3613-3p hsa-miR-92b hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmid: EOMES 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EOMES (see all 4)
    OriGene shRNA RFP: EOMES
    OriGene siRNA: EOMES
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EOMES
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EOMES (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EOMES
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: EOMES (NM_005442)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EOMES
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat EOMES 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EOMES
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EOMES
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EOMES
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EOMES

    Additional cDNA sequence: 

    AB031038.1 AK297389.1 AK297461.1 AK299499.1 AK299695.1 AK316166.1 BC025363.1 BC037568.1 
    BC131712.1 

    4 DOTS entries:

    DT.100017509  DT.310429  DT.120840460  DT.120840453 

    24/32 AceView cDNA sequences (see all 32):

    BX090438 BM720063 BX096900 NM_005442 BC025363 AA332234 AA331172 AA323074 
    AA325492 AA083564 CA440210 AA361385 AA331789 AA333545 AA331173 BC037568 
    AW002985 BI838165 AI206727 AA333532 AA083565 AW963541 AA961425 AW795410 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for EOMES    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:                                                      
    SP2:                                            -         
    SP3:        -                                             


    ECgene alternative splicing isoforms for EOMES

    Expression
    for EOMES gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EOMES expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTGCCCTAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    EOMES expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/16 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 16) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    ChorionChorion BilayerChorionic Ectoderm CellsExtraembryonic Tissues, Placenta
    EyeGanglion Cell LayerMature Ganglion CellsGanglion, Retina
    TrophoblastExtraembryonic EctodermExtraembryonic Ectoderm CellsExtraembryonic Tissues, Placenta
    TrophoblastTrophoblastTrophoblast CellsExtraembryonic Tissues
    TrophoblastTrophoblastTrophoblast CellsExtraembryonic Tissues
    Inner Cell MassInner Cell MassInner Cell Mass CellsEarly Embryo
    Early Embryo (Zygote)Morula8-Cell EmbryoEarly Embryo
    Early Embryo (Zygote)MorulaMorula CellsEarly Embryo
    Early Embryo (Zygote)MorulaMorula CellsEarly Embryo
    Early Embryo (Zygote)Zygote2-Cell EmbryoEarly Embryo
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10 LifeMap Cells 
    NameCategory
    Extra-embryonic endoderm cells (Fetal Stem / Progenitor Cell)Extraembryonic Tissues
    Definitive endoderm-like cells (Generation and expan...)
    Mesendoderm-like cells (A scalable, suspensi...)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Primitive streak-like cells (Generation of endode...)
    Endoderm-like cells (Generation of hepato...)
    Endoderm-like cells (Functional hepatocyt...)
    Mesendoderm-like cells (Generation of mesend...)
    Definitive endoderm-like cells (Generation of mesend...)
    Definitive Endoderm (Generation of beta c...)

    See EOMES Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EOMES

    SOURCE GeneReport for Unigene cluster: Hs.591663

    UniProtKB/Swiss-Prot: EOMES_HUMAN, O95936
    Tissue specificity: Expressed in CD8+ T-cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including EOMES: 
              Embryonic Stem Cells in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EOMES
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EOMES

    Orthologs
    for EOMES gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for EOMES gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves EOMES1 eomesodermin 77.72(n)
    83.41(a)    		   428443  XM_426003.3  XP_426003.3 
    lizard
    (Anolis carolinensis)    		 Reptilia EOMES6
    		 --
    		 84(a)
    		 1 ↔ 1
    		 1(196231881-196243975)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3980652 eomesodermin 76.2(n)    U75996.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii eomes2 eomesodermin homolog 75.5(n)   64603  AF329830.1 


    ENSEMBL Gene Tree for EOMES (if available)
    TreeFam Gene Tree for EOMES (if available) 

    Paralogs
    for EOMES gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EOMES gene
    TBX12  TBX222  TBX192  T2  TBX22  TBX62  TBX212  TBX32  
    TBX202  TBX52  TBX102  TBX42  TBX152  TBR12  TBX182  
    7 SIMAP similar genes for EOMES using alignment to 3 protein entries:     EOMES_HUMAN (see all proteins):
    TBR1    TBX18    TBX6    TBX10    TBX21    T
    TBX5

    EOMES for paralogs           About GeneDecksing



    Genomic Variants
    for EOMES gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/154 NCBI SNPs in EOMES are shown (see all 154)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1890990211,2
    		--27757381(+) GGAAGC/GAAAAT 1 -- ds50010--------
    rs10788481,2
    		C,F,H,--27757392(-) TTAAAG/TATCTC 1 -- ds500114Minor allele frequency- T:0.04NS EA NA CSA 1827
    rs1824888511,2
    		--27757448(+) GTTCCA/CTTACT 1 -- ds50010--------
    rs1388594511,2
    		--27757533(+) GTATCA/TGGTTT 1 -- ds50010--------
    rs1871658561,2
    		--27757582(+) CGCAAC/GAAGAG 1 -- ds50010--------
    rs1427923951,2
    		--27757717(+) TGCCCC/TTGCAG 1 -- ds50010--------
    rs748039851,2
    		C,--27757888(+) TTTTTG/TGTGAC 1 -- ut310--------
    rs1474954581,2
    		--27758120(+) TCTCCA/TTCTGA 1 -- ut310--------
    rs1920410661,2
    		--27758137(+) AGGCAC/GAGCCC 1 -- ut310--------
    rs1829128041,2
    		--27758227(+) TAACTC/GATCTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for EOMES (27757440 - 27764206 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for EOMES: --
    Human Gene Mutation Database (HGMD): EOMES

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EOMES
    DNA2.0 Custom Variant and Variant Library Synthesis for EOMES

    Disorders / Diseases
    for EOMES gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EOMES for disorders           About GeneDecksing

    OMIM gene information: 604615    OMIM disorders: --

    UniProtKB/Swiss-Prot: EOMES_HUMAN, O95936
  • Note=A translocation t(3;10)(p24;q23) located 215 kb 3' to the EOMES gene but leading to loss of its
    • expression was identified in a large consanguineous family. Homozygous silencing produces microcephaly associated with
    corpus callosum agenesis, bilateral polymicrogyria, ventricular dilatation and a small cerebellum

    10 diseases for EOMES:    About MalaCards
    corpus callosum agenesis    corpus callosum    polymicrogyria    embryonal carcinoma
    microcephaly    pharyngitis    colorectal cancer    cerebritis
    carcinoma    neuronitis


    Export disorders for EOMES gene to outside databases

    Publications
    for EOMES gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EOMES gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with EOMES)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19. (PubMed id 9888994)1, 2, 3, 9 Yi C.-H.... Brook J.D. (1999)
    2. The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer. (PubMed id 17566017)1, 2, 9 Atreya I....Neurath M.F. (2007)
    3. Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis. (PubMed id 17353897)1, 2, 9 Baala L.... Lyonnet S. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain. (PubMed id 10407135)1, 2 Kimura N.... Taga T. (1999)
    6. Genomic structure of TBX2 indicates conservation with distantly related T-box genes. (PubMed id 9434949)1, 3 Campbell C.E....Goodrich K. (1998)
    7. [Role of transcription factor T-bet and Eomes in IFN- gamma secretion of different human T cell subsets] (PubMed id 20056084)1, 9 Wang H.T....Li B.Q. (2010)
    8. Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B). (PubMed id 18523274)1, 9 Araki Y....Weng N.P. (2008)
    9. Human Th1 cells that express CD300a are polyfunctiona l and after stimulation up-regulate the T-box transcription factor eomesodermin . (PubMed id 20498708)1, 9 Narayanan S....Borrego F. (2010)
    10. Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic eff ectors. (PubMed id 22490682)1 Ribeiro-dos-Santos P....Rocha B. (2012)

    External Searches for EOMES gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing EOMES gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8320 HGNC: 3372 AceView: EOMES Ensembl:ENSG00000163508 euGenes: HUgn8320
    ECgene: EOMES H-InvDB: EOMES

    Other Databases showing EOMES gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing EOMES gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EOMES Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for EOMES gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for EOMES gene:
    Search GeneIP for patents involving EOMES

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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