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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EOMES Gene

protein-coding   GIFtS: 59
GCID: GC03M027757

Eomesodermin

(Previous name: eomesodermin (Xenopus laevis) homolog)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
eomesodermin1 2     T-Box Brain21
TBR22 3 5     Eomesodermin Homolog2
T-Box Brain Protein 22 3     T-brain-23
Eomesodermin (Xenopus Laevis) Homolog1     TBR-23

External Ids:    HGNC: 33721   Entrez Gene: 83202   Ensembl: ENSG000001635087   OMIM: 6046155   UniProtKB: O959363   

Export aliases for EOMES gene to outside databases

Previous GC identifers: GC03M027209 GC03M027607 GC03M027732 GC03M027700


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EOMES Gene:
This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding
T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of
mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation
of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice
is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, May 2013)

GeneCards Summary for EOMES Gene: 
EOMES (eomesodermin) is a protein-coding gene. Diseases associated with EOMES include microcephaly - polymicrogyria - corpus callosum agenesis, and bilateral polymicrogyria, and among its related super-pathways are Immune response IL-12-induced IFN-gamma production. GO annotations related to this gene include RNA polymerase II activating transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TBX1.

UniProtKB/Swiss-Prot: EOMES_HUMAN, O95936
Function: Functions as a transcriptional activator playing a crucial role during development. Functions in
trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm
specification. Plays a role in brain development being required for the specification and the proliferation of
the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation
of CD8+ T-cells during immune response regulating the expression of lytic effector genes

Gene Wiki entry for EOMES (Eomesodermin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EOMES gene promoter:
         STAT1   p53   AP-1   ATF-2   STAT1beta   c-Jun   Pax-4a   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEOMES promoter sequence
   Search SABiosciences Chromatin IP Primers for EOMES

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EOMES


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.1   Ensembl cytogenetic band:  3p24.1   HGNC cytogenetic band: 3p24.1

EOMES Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EOMES gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M027757:  view genomic region     (about GC identifiers)

Start:
27,757,440 bp from pter      End:
27,764,206 bp from pter
Size:
6,767 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EOMES_HUMAN, O95936 (See protein sequence)
Recommended Name: Eomesodermin homolog  
Size: 686 amino acids; 72732 Da
Subcellular location: Nucleus (Probable)
Developmental stage: Detected at 7 weeks of development in the forebrain floorplate of the CNS. Expressed within
the mantle layer and migrating neuroblasts of the telencephalon at 12.5 weeks of development
Secondary accessions: B7Z4I2 Q8TAZ2 Q9UPM7
Alternative splicing: 2 isoforms:  O95936-1   O95936-2   

Explore the universe of human proteins at neXtProt for EOMES: NX_O95936

Explore proteomics data for EOMES at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95936

  • EOMES Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EOMES Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001265111.1  NP_001265112.1  NP_005433.2  

    ENSEMBL proteins: 
     ENSP00000295743   ENSP00000388620   ENSP00000442097  

    Human Recombinant Protein Products for EOMES: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for EOMES
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for EOMES
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    Novus Biologicals EOMES Proteins
    Novus Biologicals EOMES Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EOMES 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    EOMES for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for EOMES 
    Cloud-Clone Corp. CLIAs for EOMES


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TBX: T-boxes

    3 InterPro protein domains:
     IPR001699 TF_T-box
     IPR008967 p53-like_TF_DNA-bd
     IPR018186 TF_T-box_CS

    Graphical View of Domain Structure for InterPro Entry O95936

    ProtoNet protein and cluster: O95936

    1 Blocks protein domain: IPB001699 Transcription factor

    UniProtKB/Swiss-Prot: EOMES_HUMAN, O95936
    Similarity: Contains 1 T-box DNA-binding domain


    EOMES for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EOMES_HUMAN, O95936
    Function: Functions as a transcriptional activator playing a crucial role during development. Functions in
    trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm
    specification. Plays a role in brain development being required for the specification and the proliferation of
    the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation
    of CD8+ T-cells during immune response regulating the expression of lytic effector genes
    Induction: Up-regulated in CD8+ T-cells simultaneously stimulated with TGFB1 and IL4/interleukin-4

         Genatlas biochemistry entry for EOMES:
    eomesodermin,expressed in forebrain and T lymphocyte (T,brachyury,TBR1 subfamily),involved in developmental
    regulation

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IEA--
    GO:0001102RNA polymerase II activating transcription factor binding ISS--
    GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription ISS--
    GO:0003677DNA binding ISS--
    GO:0003682chromatin binding IEA--
         
    EOMES for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for EOMES:
     Decreased Hepatitis C virus re 

         13 MGI mutant phenotypes (inferred from 11 alleles(MGI details for Eomes):
     behavior/neurological  cellular  embryogenesis  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  nervous system  no phenotypic analysis  normal 
     reproductive system  tumorigenesis  vision/eye 

    EOMES for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for EOMES: Eomestm1.1Rob Eomestm1.1Whk Eomestm1Jrt

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EOMES 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EOMES

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EOMES 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EOMES 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EOMES
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate EOMES (see all 22):
    hsa-miR-25 hsa-miR-1271 hsa-miR-3190 hsa-miR-103a hsa-miR-1184 hsa-miR-3613-3p hsa-miR-92b hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidEOMES 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EOMES
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                         Customized lentivirus expression plasmids for stable overexpression of EOMES 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EOMES


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EOMES About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune response IL-12-induced IFN-gamma production
    IL12-mediated signaling events0.33
    2Transcriptional Regulatory Network in Embryonic Stem Cell
    Transcriptional Regulatory Network in Embryonic Stem Cell
    3Selected targets of Oct-3/4
    Selected targets of Oct-3/4
    4Downstream signaling in naive CD8+ T cells
    Downstream signaling in naive CD8+ T cells

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for EOMES
        Selected targets of Oct-3/4

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for EOMES
        Transcriptional Regulatory Network in Embryonic Stem Cell

    2 BioSystems Pathways for EOMES
        Downstream signaling in naive CD8+ T cells
    IL12-mediated signaling events



    EOMES for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EOMES

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/17 Interacting proteins for EOMES (O959362, 3 ENSP000002957434) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PFDN1O609252, 3MINT-8265808 I2D: score=2 
    CD247ENSP000003547824STRING: ENSP00000354782
    CD3DENSP000003006924STRING: ENSP00000300692
    CD3EENSP000003545664STRING: ENSP00000354566
    CD3GENSP000002921444STRING: ENSP00000292144
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001706endoderm formation ISS--
    GO:0001707mesoderm formation ISS--
    GO:0001714endodermal cell fate specification IEA--
    GO:0001824blastocyst development ----

    EOMES for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EOMES

    Search CenterWatch for drugs/clinical trials and news about EOMES

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EOMES gene (3 alternative transcripts): 
    NM_001278182.1  NM_001278183.1  NM_005442.3  

    Unigene Cluster for EOMES:

    Eomesodermin
    Hs.591663  [show with all ESTs]
    Unigene Representative Sequence: BC037568
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295743(uc003cdx.3) ENST00000449599(uc003cdy.3 uc010hfn.2)
    ENST00000461503 ENST00000537516(uc011axc.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EOMES
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate EOMES (see all 22):
    hsa-miR-25 hsa-miR-1271 hsa-miR-3190 hsa-miR-103a hsa-miR-1184 hsa-miR-3613-3p hsa-miR-92b hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidEOMES 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for EOMES
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EOMES
    Clone
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    OriGene clones in human, mouse for EOMES (see all 8)
    OriGene ORF clones in mouse, rat for EOMES
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EOMES (NM_005442)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EOMES
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat EOMES
    Sirion Biotech Customized lentivirus for stable overexpression of EOMES 
                         Customized lentivirus expression plasmids for stable overexpression of EOMES 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EOMES
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EOMES

    Additional mRNA sequence: 

    AB031038.1 AK297389.1 AK297461.1 AK299499.1 AK299695.1 AK316166.1 BC025363.1 BC037568.1 
    BC131712.1 

    4 DOTS entries:

    DT.100017509  DT.310429  DT.120840460  DT.120840453 

    24/32 AceView cDNA sequences (see all 32):

    AA323074 BC025363 NM_005442 BM720063 AA332234 BX096900 AA331172 AA325492 
    BX090438 AA331789 AW002985 AA361385 BI838165 AA083564 AA333545 CA440210 
    BC037568 AA331173 AI206727 AB031038 AW963541 AA083565 AW795410 AA333532 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for EOMES    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:                                                      
    SP2:                                            -         
    SP3:        -                                             


    ECgene alternative splicing isoforms for EOMES

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EOMES expression in normal human tissues (normalized intensities)      EOMES embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGCCCTAG
    EOMES Expression
    About this image


    EOMES expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/19 selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 22 entries
             Thalamus
             Stria terminalis   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 9 entries
             Inner Cell Mass Cells Inner Cell Mass
             Line H9 (WA09)
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 9 entries
             Trophoblast Cells Trophoblast
     
     Zygote (Early Embryonic Tissues)    fully expand to see all 6 entries
             Morula Cells Morula
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 5 entries
             Primitive Streak Cells Primitive Streak
             Primitive streak-like cells ( Generation of endoderm cells and pancreatic progenitor...

    See EOMES Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EOMES

    SOURCE GeneReport for Unigene cluster: Hs.591663

    UniProtKB/Swiss-Prot: EOMES_HUMAN, O95936
    Tissue specificity: Expressed in CD8+ T-cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including EOMES: 
              Embryonic Stem Cells in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EOMES
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EOMES

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for EOMES gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eomes1 , 5 eomesodermin homolog (Xenopus laevis)1, 5 86.53(n)1
    91.45(a)1
      9 (70.21 cM)5
    138131  NM_010136.31  NP_034266.21 
     1184782125 
    chicken
    (Gallus gallus)
    Aves EOMES1 eomesodermin 77.72(n)
    83.41(a)
      428443  XM_426003.3  XP_426003.3 
    lizard
    (Anolis carolinensis)
    Reptilia EOMES6
    Uncharacterized protein
    84(a)
    1 ↔ 1
    1(196231800-196243975)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980652 eomesodermin 76.2(n)    U75996.1 
    zebrafish
    (Danio rerio)
    Actinopterygii eomes2 eomesodermin homolog 75.5(n)   64603  AF329830.1 


    ENSEMBL Gene Tree for EOMES (if available)
    TreeFam Gene Tree for EOMES (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EOMES gene
    TBX12  TBX222  TBX192  T2  TBX22  TBX62  TBX212  TBX202  
    TBX32  TBX52  TBX152  TBR12  TBX42  TBX102  TBX182  
    6 SIMAP similar genes for EOMES using alignment to 3 protein entries:     EOMES_HUMAN (see all proteins):
    TBR1    TBX18    TBX6    TBX10    TBX21    T

    EOMES for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/220 SNPs in EOMES are shown (see all 220)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360694
    A breast cancer sample4--see VAR_0360692 E Q mis40--------
    rs23711081,2
    C,F--27757018(+) GATGGG/TTGGCC 3 -- ds50018Minor allele frequency- T:0.49NA CSA WA EA 368
    rs28879431,2
    C,H--27757152(+) GCAATC/TTTCCC 3 -- ds50012Minor allele frequency- T:0.00NS NA 228
    rs1890990211,2
    --27757381(+) GGAAGC/GAAAAT 3 -- ds50010--------
    rs10788481,2
    C,F,H--27757392(-) TTAAAG/TATCTC 3 -- ds500114Minor allele frequency- T:0.04NS EA NA CSA 1827
    rs1824888511,2
    --27757448(+) GTTCCA/CTTACT 3 -- ut310--------
    rs1388594511,2
    --27757533(+) GTATCA/TGGTTT 3 -- ut310--------
    rs1871658561,2
    --27757582(+) CGCAAC/GAAGAG 3 -- ut310--------
    rs1427923951,2
    --27757717(+) TGCCCC/TTGCAG 3 -- ut310--------
    rs113752601,2
    C--27757867(+) CTCCC-/TTTTTT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for EOMES (27757440 - 27764206 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for EOMES: --

    Human Gene Mutation Database (HGMD): EOMES
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing EOMES
    DNA2.0 Custom Variant and Variant Library Synthesis for EOMES

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604615    OMIM disorders: --

    UniProtKB/Swiss-Prot: EOMES_HUMAN, O95936
  • Note=A translocation t(3;10)(p24;q23) located 215 kb 3' to the EOMES gene but leading to loss of its
    expression was identified in a large consanguineous family. Homozygous silencing produces microcephaly associated
    with corpus callosum agenesis, bilateral polymicrogyria, ventricular dilatation and a small cerebellum

  • 9 diseases for EOMES:    About MalaCards
    microcephaly - polymicrogyria - corpus callosum agenesis    bilateral polymicrogyria    corpus callosum agenesis    polymicrogyria
    microcephaly    cerebritis    colorectal cancer    multiple sclerosis
    neuronitis


    EOMES for disorders           About GeneDecksing

    Genetic Association Database (GAD): EOMES

    Export disorders for EOMES gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EOMES gene, integrated from 9 sources (see all 77):
    (articles sorted by number of sources associating them with EOMES)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19. (PubMed id 9888994)1, 2, 3, 9 Yi C.-H.... Brook J.D. (1999)
    2. The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer. (PubMed id 17566017)1, 2, 9 Atreya I....Neurath M.F. (2007)
    3. Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis. (PubMed id 17353897)1, 2, 9 Baala L.... Lyonnet S. (2007)
    4. Genome-wide meta-analysis identifies novel multiple sc lerosis susceptibility loci. (PubMed id 22190364)1, 4 Patsopoulos N.A....de Bakker P.I. (2011)
    5. Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (2011)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain. (PubMed id 10407135)1, 2 Kimura N.... Taga T. (1999)
    8. [Role of transcription factor T-bet and Eomes in IFN- gamma secretion of different human T cell subsets] (PubMed id 20056084)1, 9 Wang H.T....Li B.Q. (2010)
    9. Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B). (PubMed id 18523274)1, 9 Araki Y....Weng N.P. (2008)
    10. Human Th1 cells that express CD300a are polyfunctiona l and after stimulation up-regulate the T-box transcription factor eomesodermin . (PubMed id 20498708)1, 9 Narayanan S....Borrego F. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8320 HGNC: 3372 AceView: EOMES Ensembl:ENSG00000163508 euGenes: HUgn8320
    ECgene: EOMES H-InvDB: EOMES

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EOMES Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EOMES gene:
    Search GeneIP for patents involving EOMES

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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