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Aliases for EOMES Gene

Aliases for EOMES Gene

  • Eomesodermin 2 3
  • TBR2 3 4 6
  • T-Box Brain Protein 2 3 4
  • Eomesodermin (Xenopus Laevis) Homolog 2
  • Eomesodermin Homolog 3
  • T-Box Brain2 2
  • T-Brain-2 4
  • TBR-2 4

External Ids for EOMES Gene

Summaries for EOMES Gene

Entrez Gene Summary for EOMES Gene

  • This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for EOMES Gene

EOMES (Eomesodermin) is a Protein Coding gene. Diseases associated with EOMES include microcephaly - polymicrogyria - corpus callosum agenesis. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and Downstream signaling in naive CD8+ T cells. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is MGA.

UniProtKB/Swiss-Prot for EOMES Gene

  • Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.

Gene Wiki entry for EOMES Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EOMES Gene

Genomics for EOMES Gene

Genomic Location for EOMES Gene

Start:
27,715,949 bp from pter
End:
27,722,715 bp from pter
Size:
6,767 bases
Orientation:
Minus strand

Genomic View for EOMES Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EOMES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EOMES Gene

Regulatory Elements for EOMES Gene

Proteins for EOMES Gene

  • Protein details for EOMES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95936-EOMES_HUMAN
    Recommended name:
    Eomesodermin homolog
    Protein Accession:
    O95936
    Secondary Accessions:
    • B7Z4I2
    • B7ZA51
    • G3XAI5
    • Q8TAZ2
    • Q9UPM7

    Protein attributes for EOMES Gene

    Size:
    686 amino acids
    Molecular mass:
    72732 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EOMES Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EOMES Gene

Proteomics data for EOMES Gene at MOPED

Post-translational modifications for EOMES Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EOMES Gene

No data available for DME Specific Peptides for EOMES Gene

Domains for EOMES Gene

Gene Families for EOMES Gene

HGNC:

Protein Domains for EOMES Gene

UniProtKB/Swiss-Prot:

EOMES_HUMAN
Domain:
  • Contains 1 T-box DNA-binding domain.:
    • O95936
genes like me logo Genes that share domains with EOMES: view

Function for EOMES Gene

Molecular function for EOMES Gene

GENATLAS Biochemistry: eomesodermin,expressed in forebrain and T lymphocyte (T,brachyury,TBR1 subfamily),involved in developmental regulation
UniProtKB/Swiss-Prot Function: Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.
UniProtKB/Swiss-Prot Induction: Up-regulated in CD8+ T-cells simultaneously stimulated with TGFB1 and IL4/interleukin-4.

Gene Ontology (GO) - Molecular Function for EOMES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001102 RNA polymerase II activating transcription factor binding ISS --
GO:0001191 RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription ISS --
GO:0003677 DNA binding ISS --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with EOMES: view
genes like me logo Genes that share phenotypes with EOMES: view

Animal Models for EOMES Gene

MGI Knock Outs for EOMES:

miRNA for EOMES Gene

miRTarBase miRNAs that target EOMES
Targeting motifs for EOMES Gene
HOMER Transcription Factor Regulatory Elements motif EOMES
  • Consensus sequence: ATTAACACCT Submotif: canonical Cell Type: H9 GeoId: GSE26097

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for EOMES Gene

Localization for EOMES Gene

Subcellular locations from UniProtKB/Swiss-Prot for EOMES Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EOMES Gene COMPARTMENTS Subcellular localization image for EOMES gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for EOMES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with EOMES: view

Pathways for EOMES Gene

genes like me logo Genes that share pathways with EOMES: view

Pathways by source for EOMES Gene

Gene Ontology (GO) - Biological Process for EOMES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001706 endoderm formation ISS --
GO:0001707 mesoderm formation ISS --
GO:0001714 endodermal cell fate specification IEA --
GO:0001824 blastocyst development --
genes like me logo Genes that share ontologies with EOMES: view

Transcripts for EOMES Gene

Unigene Clusters for EOMES Gene

Eomesodermin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EOMES Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3: -

Relevant External Links for EOMES Gene

GeneLoc Exon Structure for
EOMES
ECgene alternative splicing isoforms for
EOMES

Expression for EOMES Gene

mRNA expression in normal human tissues for EOMES Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EOMES Gene

This gene is overexpressed in Whole Blood (12.8), Brain - Cerebellar Hemisphere (11.7), Brain - Cerebellum (11.4), and Spleen (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EOMES Gene

SOURCE GeneReport for Unigene cluster for EOMES Gene Hs.591663

mRNA Expression by UniProt/SwissProt for EOMES Gene

O95936-EOMES_HUMAN
Tissue specificity: Expressed in CD8+ T-cells.
genes like me logo Genes that share expressions with EOMES: view

Orthologs for EOMES Gene

This gene was present in the common ancestor of animals.

Orthologs for EOMES Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EOMES 36
  • 99.75 (n)
  • 99.81 (a)
EOMES 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EOMES 36
  • 91.54 (n)
  • 95.75 (a)
EOMES 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EOMES 36
  • 93.24 (n)
  • 96.74 (a)
EOMES 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eomes 36
  • 86.99 (n)
  • 91.54 (a)
Eomes 16
Eomes 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EOMES 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EOMES 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eomes 36
  • 88.37 (n)
  • 95.37 (a)
chicken
(Gallus gallus)
Aves EOMES 36
  • 77.26 (n)
  • 81.33 (a)
EOMES 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EOMES 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398065 36
tropical clawed frog
(Silurana tropicalis)
Amphibia eomes 36
  • 70.42 (n)
  • 72.11 (a)
Str.14985 36
zebrafish
(Danio rerio)
Actinopterygii eomes 36
eomesa 36
  • 64.37 (n)
  • 66.35 (a)
eomesa 37
  • 62 (a)
OneToMany
eomesb 37
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tbx-11 37
  • 23 (a)
ManyToMany
tbx-30 37
  • 17 (a)
ManyToMany
tbx-34 37
  • 20 (a)
ManyToMany
tbx-35 37
  • 20 (a)
ManyToMany
tbx-37 37
  • 26 (a)
ManyToMany
tbx-38 37
  • 24 (a)
ManyToMany
tbx-39 37
  • 15 (a)
ManyToMany
tbx-40 37
  • 16 (a)
ManyToMany
tbx-42 37
  • 17 (a)
ManyToMany
tbx-43 37
  • 24 (a)
ManyToMany
tbx-8 37
  • 27 (a)
ManyToMany
tbx-9 37
  • 30 (a)
ManyToMany
tbx-9 38
  • 41 (a)
tbx-8 38
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7001 37
  • 16 (a)
OneToMany
Species with no ortholog for EOMES:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EOMES Gene

ENSEMBL:
Gene Tree for EOMES (if available)
TreeFam:
Gene Tree for EOMES (if available)

Paralogs for EOMES Gene

Paralogs for EOMES Gene

Selected SIMAP similar genes for EOMES Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EOMES: view

Variants for EOMES Gene

Sequence variations from dbSNP and Humsavar for EOMES Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs751718 -- 27,723,804(+) GGAGA(A/T)GCCTG upstream-variant-2KB
rs1078848 -- 27,715,901(-) TTAAA(G/T)ATCTC downstream-variant-500B
rs1874198 Benign 27,721,936(+) CGGCG(C/G)CTGCA reference, missense, intron-variant
rs2371108 -- 27,715,527(+) GATGG(G/T)TGGCC downstream-variant-500B
rs2371109 -- 27,716,783(+) TTGAA(G/T)GGTTA utr-variant-3-prime

Relevant External Links for EOMES Gene

HapMap Linkage Disequilibrium report
EOMES
Human Gene Mutation Database (HGMD)
EOMES

No data available for Structural Variations from Database of Genomic Variants (DGV) for EOMES Gene

Disorders for EOMES Gene

UniProtKB/Swiss-Prot

EOMES_HUMAN
  • Note=A translocation t(3;10)(p24;q23) located 215 kb 3 to the EOMES gene but leading to loss of its expression was identified in a large consanguineous family. Homozygous silencing produces microcephaly associated with corpus callosum agenesis, bilateral polymicrogyria, ventricular dilatation and a small cerebellum.

Relevant External Links for EOMES

Genetic Association Database (GAD)
EOMES
genes like me logo Genes that share disorders with EOMES: view

Publications for EOMES Gene

  1. Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19. (PMID: 9888994) Yi C.-H. … Brook J.D. (Genomics 1999) 2 3 4 23
  2. Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis. (PMID: 17353897) Baala L. … Lyonnet S. (Nat. Genet. 2007) 3 4 23
  3. The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer. (PMID: 17566017) Atreya I. … Neurath M.F. (Gut 2007) 3 4 23
  4. [Role of transcription factor T-bet and Eomes in IFN-gamma secretion of different human T cell subsets]. (PMID: 20056084) Wang H.T. … Li B.Q. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for EOMES Gene

Sources for EOMES Gene

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