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Aliases for EOMES Gene

Aliases for EOMES Gene

  • Eomesodermin 2 3 5
  • T-Box Brain Protein 2 3 4
  • TBR2 3 4
  • Eomesodermin (Xenopus Laevis) Homolog 2
  • Eomesodermin Homolog 3
  • T-Box Brain2 2
  • T-Brain-2 4
  • TBR-2 4

External Ids for EOMES Gene

Previous GeneCards Identifiers for EOMES Gene

  • GC03M027209
  • GC03M027607
  • GC03M027732
  • GC03M027757
  • GC03M027700

Summaries for EOMES Gene

Entrez Gene Summary for EOMES Gene

  • This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for EOMES Gene

EOMES (Eomesodermin) is a Protein Coding gene. Diseases associated with EOMES include Microcephaly-Polymicrogyria-Corpus Callosum Agenesis Syndrome and Microcephaly With Polymicrogyria. Among its related pathways are Mesodermal Commitment Pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is TBR1.

UniProtKB/Swiss-Prot for EOMES Gene

  • Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.

Gene Wiki entry for EOMES Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EOMES Gene

Genomics for EOMES Gene

Regulatory Elements for EOMES Gene

Enhancers for EOMES Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G027712 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.8 +7.4 7440 5.9 HDGF PKNOX1 FOXA2 WRNIP1 SIN3A RAD21 ZNF143 FOS RELB IKZF2 LINC02084 EOMES GC03P027722
GH03G027756 0.7 ENCODE 11.7 -34.8 -34806 2.9 TBP ZNF263 CTCF PKNOX1 JUN CEBPB DPF2 RAD21 EP300 RFX5 EOMES GC03M027768
GH03G028008 0.8 FANTOM5 7.7 -285.7 -285650 0.4 CTCF TBP MTA2 NR2F1 BACH1 CHD1 GATAD2B DPF2 TBX21 ATF2 EOMES CMC1 LINC01967 GC03P027916
GH03G028009 0.7 FANTOM5 5.5 -286.9 -286872 0.4 PKNOX1 FOXA2 NFIA NFIB MTA2 BHLHE40 HLF GATA3 NFIC JUND EOMES CMC1 LINC01967 GC03P027916
GH03G028134 0.6 FANTOM5 6 -411.9 -411876 0.2 NFIC RAD51 MXI1 NFIB TBX21 EOMES CMC1 GC03M028132 LOC105377008
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EOMES on UCSC Golden Path with GeneCards custom track

Promoters for EOMES Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000150031 715 801 TBP NFXL1 RAD21 GLIS2 ZNF366 ZNF143 RELB IKZF2 ZNF263 ZNF654

Genomic Location for EOMES Gene

Chromosome:
3
Start:
27,715,949 bp from pter
End:
27,722,715 bp from pter
Size:
6,767 bases
Orientation:
Minus strand

Genomic View for EOMES Gene

Genes around EOMES on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EOMES Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EOMES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EOMES Gene

Proteins for EOMES Gene

  • Protein details for EOMES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95936-EOMES_HUMAN
    Recommended name:
    Eomesodermin homolog
    Protein Accession:
    O95936
    Secondary Accessions:
    • B7Z4I2
    • B7ZA51
    • G3XAI5
    • Q8TAZ2
    • Q9UPM7

    Protein attributes for EOMES Gene

    Size:
    686 amino acids
    Molecular mass:
    72732 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EOMES Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EOMES Gene

Post-translational modifications for EOMES Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EOMES Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EOMES (EOMES)
  • Cloud-Clone Corp. Antibodies for EOMES
  • Santa Cruz Biotechnology (SCBT) Antibodies for EOMES

No data available for DME Specific Peptides for EOMES Gene

Domains & Families for EOMES Gene

Gene Families for EOMES Gene

Protein Domains for EOMES Gene

Suggested Antigen Peptide Sequences for EOMES Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EOMES: view

No data available for UniProtKB/Swiss-Prot for EOMES Gene

Function for EOMES Gene

Molecular function for EOMES Gene

GENATLAS Biochemistry:
eomesodermin,expressed in forebrain and T lymphocyte (T,brachyury,TBR1 subfamily),involved in developmental regulation
UniProtKB/Swiss-Prot Function:
Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.
UniProtKB/Swiss-Prot Induction:
Up-regulated in CD8+ T-cells simultaneously stimulated with TGFB1 and IL4/interleukin-4.

Gene Ontology (GO) - Molecular Function for EOMES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001102 RNA polymerase II activating transcription factor binding ISS --
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding ISS --
GO:0003677 DNA binding ISS --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with EOMES: view
genes like me logo Genes that share phenotypes with EOMES: view

Animal Models for EOMES Gene

MGI Knock Outs for EOMES:

Animal Model Products

CRISPR Products

miRNA for EOMES Gene

miRTarBase miRNAs that target EOMES
Targeted motifs for EOMES Gene
HOMER Transcription Factor Regulatory Elements motif EOMES
  • Consensus sequence: ATTAACACCT Submotif: canonical Cell Type: H9 GEO ID: GSE26097

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for EOMES Gene

Localization for EOMES Gene

Subcellular locations from UniProtKB/Swiss-Prot for EOMES Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EOMES gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for EOMES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with EOMES: view

Pathways & Interactions for EOMES Gene

genes like me logo Genes that share pathways with EOMES: view

Gene Ontology (GO) - Biological Process for EOMES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001706 endoderm formation ISS --
GO:0001707 mesoderm formation ISS --
GO:0001714 endodermal cell fate specification IEA --
GO:0001824 blastocyst development IEA --
genes like me logo Genes that share ontologies with EOMES: view

No data available for SIGNOR curated interactions for EOMES Gene

Transcripts for EOMES Gene

Unigene Clusters for EOMES Gene

Eomesodermin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EOMES Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3: -

Relevant External Links for EOMES Gene

GeneLoc Exon Structure for
EOMES
ECgene alternative splicing isoforms for
EOMES

Expression for EOMES Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EOMES Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EOMES Gene

This gene is overexpressed in Whole Blood (x12.8), Brain - Cerebellar Hemisphere (x11.7), Brain - Cerebellum (x11.4), and Spleen (x6.4).

Protein differential expression in normal tissues from HIPED for EOMES Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (63.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EOMES Gene



Protein tissue co-expression partners for EOMES Gene

NURSA nuclear receptor signaling pathways regulating expression of EOMES Gene:

EOMES

SOURCE GeneReport for Unigene cluster for EOMES Gene:

Hs.591663

mRNA Expression by UniProt/SwissProt for EOMES Gene:

O95936-EOMES_HUMAN
Tissue specificity: Expressed in CD8+ T-cells.

Evidence on tissue expression from TISSUES for EOMES Gene

  • Nervous system(4.6)
  • Blood(2.4)
  • Spleen(2)
genes like me logo Genes that share expression patterns with EOMES: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for EOMES Gene

Orthologs for EOMES Gene

This gene was present in the common ancestor of animals.

Orthologs for EOMES Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EOMES 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia EOMES 34 35
  • 93.24 (n)
cow
(Bos Taurus)
Mammalia EOMES 34 35
  • 91.54 (n)
rat
(Rattus norvegicus)
Mammalia Eomes 34
  • 88.37 (n)
mouse
(Mus musculus)
Mammalia Eomes 34 16 35
  • 86.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EOMES 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EOMES 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves EOMES 34 35
  • 77.26 (n)
lizard
(Anolis carolinensis)
Reptilia EOMES 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eomes 34
  • 70.42 (n)
Str.14985 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398065 34
zebrafish
(Danio rerio)
Actinopterygii eomesa 34 35
  • 64.37 (n)
eomesb 35
  • 58 (a)
OneToMany
eomes 34
worm
(Caenorhabditis elegans)
Secernentea tbx-9 36 35
  • 41 (a)
tbx-8 36 35
  • 38 (a)
tbx-37 35
  • 26 (a)
ManyToMany
tbx-38 35
  • 24 (a)
ManyToMany
tbx-43 35
  • 24 (a)
ManyToMany
tbx-11 35
  • 23 (a)
ManyToMany
tbx-34 35
  • 20 (a)
ManyToMany
tbx-35 35
  • 20 (a)
ManyToMany
tbx-30 35
  • 17 (a)
ManyToMany
tbx-42 35
  • 17 (a)
ManyToMany
tbx-40 35
  • 16 (a)
ManyToMany
tbx-39 35
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7001 35
  • 16 (a)
OneToMany
Species where no ortholog for EOMES was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EOMES Gene

ENSEMBL:
Gene Tree for EOMES (if available)
TreeFam:
Gene Tree for EOMES (if available)

Paralogs for EOMES Gene

Paralogs for EOMES Gene

(6) SIMAP similar genes for EOMES Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with EOMES: view

Variants for EOMES Gene

Sequence variations from dbSNP and Humsavar for EOMES Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_036069 A breast cancer sample
rs34467870 Likely benign 27,721,914(+) CAGCC(-/GCG/GCGGCG)GCGGC intron-variant, cds-indel
rs200215171 Uncertain significance 27,721,859(+) CTGGA(A/G)GTAGT intron-variant, reference, missense
rs1874198 Benign 27,721,936(+) CGGCG(C/G)CTGCA intron-variant, reference, missense
rs6783101 Benign 27,717,265(+) GAAGG(A/C/G)GGTGT reference, synonymous-codon, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EOMES Gene

Variant ID Type Subtype PubMed ID
esv3575558 CNV gain 25503493

Variation tolerance for EOMES Gene

Residual Variation Intolerance Score: 20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EOMES Gene

Human Gene Mutation Database (HGMD)
EOMES
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EOMES

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EOMES Gene

Disorders for EOMES Gene

MalaCards: The human disease database

(5) MalaCards diseases for EOMES Gene - From: GeneTests, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search EOMES in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

EOMES_HUMAN
  • Note=A translocation t(3;10)(p24;q23) located 215 kb 3 to the EOMES gene but leading to loss of its expression was identified in a large consanguineous family. Homozygous silencing produces microcephaly associated with corpus callosum agenesis, bilateral polymicrogyria, ventricular dilatation and a small cerebellum.

Relevant External Links for EOMES

Genetic Association Database (GAD)
EOMES
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EOMES
genes like me logo Genes that share disorders with EOMES: view

No data available for Genatlas for EOMES Gene

Publications for EOMES Gene

  1. Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19. (PMID: 9888994) Yi C.-H. … Brook J.D. (Genomics 1999) 2 3 4 22 64
  2. Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis. (PMID: 17353897) Baala L. … Lyonnet S. (Nat. Genet. 2007) 3 4 22 64
  3. The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer. (PMID: 17566017) Atreya I. … Neurath M.F. (Gut 2007) 3 4 22 64
  4. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 46 64
  5. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. (PMID: 22190364) Patsopoulos N.A. … de Bakker P.I. (Ann. Neurol. 2011) 3 46 64

Products for EOMES Gene

Sources for EOMES Gene

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