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EOMES Gene

protein-coding   GIFtS: 60
GCID: GC03M027757

Eomesodermin

(Previous name: eomesodermin (Xenopus laevis) homolog)
  See EOMES-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
eomesodermin1 2     T-Box Brain21
TBR22 3 5     Eomesodermin Homolog2
T-Box Brain Protein 22 3     T-brain-23
Eomesodermin (Xenopus Laevis) Homolog1     TBR-23

External Ids:    HGNC: 33721   Entrez Gene: 83202   Ensembl: ENSG000001635087   OMIM: 6046155   UniProtKB: O959363   

Export aliases for EOMES gene to outside databases

Previous GC identifers: GC03M027209 GC03M027607 GC03M027732 GC03M027700


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EOMES Gene:
This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding
T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of
mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation
of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice
is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, May 2013)

GeneCards Summary for EOMES Gene:
EOMES (eomesodermin) is a protein-coding gene. Diseases associated with EOMES include microcephaly - polymicrogyria - corpus callosum agenesis, and corpus callosum agenesis. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TBR1.

UniProtKB/Swiss-Prot: EOMES_HUMAN, O95936
Function: Functions as a transcriptional activator playing a crucial role during development. Functions in
trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm
specification. Plays a role in brain development being required for the specification and the proliferation of
the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation
of CD8+ T-cells during immune response regulating the expression of lytic effector genes

Gene Wiki entry for EOMES (Eomesodermin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EOMES gene promoter:
         STAT1   p53   AP-1   ATF-2   STAT1beta   c-Jun   Pax-4a   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEOMES promoter sequence
   Search Chromatin IP Primers for EOMES

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EOMES


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.1   Ensembl cytogenetic band:  3p24.1   HGNC cytogenetic band: 3p24.1

EOMES Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EOMES gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M027757:  view genomic region     (about GC identifiers)

Start:
27,757,440 bp from pter      End:
27,764,206 bp from pter
Size:
6,767 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EOMES_HUMAN, O95936 (See protein sequence)
Recommended Name: Eomesodermin homolog  
Size: 686 amino acids; 72732 Da
Developmental stage: Detected at 7 weeks of development in the forebrain floorplate of the CNS. Expressed within
the mantle layer and migrating neuroblasts of the telencephalon at 12.5 weeks of development
Secondary accessions: B7Z4I2 Q8TAZ2 Q9UPM7
Alternative splicing: 2 isoforms:  O95936-1   O95936-2   

Explore the universe of human proteins at neXtProt for EOMES: NX_O95936

Explore proteomics data for EOMES at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See EOMES Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001265111.1  NP_001265112.1  NP_005433.2  

    ENSEMBL proteins: 
     ENSP00000295743   ENSP00000388620   ENSP00000442097  

    EOMES Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for EOMES
    OriGene Custom MassSpec
    OriGene Custom Protein Services for EOMES
    GenScript Custom Purified and Recombinant Proteins Services for EOMES
    Novus Biologicals EOMES Proteins
    Novus Biologicals EOMES Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EOMES

     
    Search eBioscience for Proteins for EOMES 

    EOMES Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals EOMES Antibodies
    Abcam antibodies for EOMES
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    ThermoFisher Antibodies for EOMES
    LSBio Antibodies in human, mouse, rat for EOMES

    EOMES Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EOMES
    Cloud-Clone Corp. CLIAs for EOMES
    Search eBioscience for ELISAs for EOMES 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TBX: T-boxes

    3 InterPro protein domains:
     IPR001699 TF_T-box
     IPR008967 p53-like_TF_DNA-bd
     IPR018186 TF_T-box_CS

    Graphical View of Domain Structure for InterPro Entry O95936

    ProtoNet protein and cluster: O95936

    1 Blocks protein domain: IPB001699 Transcription factor

    UniProtKB/Swiss-Prot: EOMES_HUMAN, O95936
    Similarity: Contains 1 T-box DNA-binding domain


    Find genes that share domains with EOMES           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EOMES_HUMAN, O95936
    Function: Functions as a transcriptional activator playing a crucial role during development. Functions in
    trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm
    specification. Plays a role in brain development being required for the specification and the proliferation of
    the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation
    of CD8+ T-cells during immune response regulating the expression of lytic effector genes
    Induction: Up-regulated in CD8+ T-cells simultaneously stimulated with TGFB1 and IL4/interleukin-4

         Genatlas biochemistry entry for EOMES:
    eomesodermin,expressed in forebrain and T lymphocyte (T,brachyury,TBR1 subfamily),involved in developmental
    regulation

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IEA--
    GO:0001102RNA polymerase II activating transcription factor binding ISS--
    GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription ISS--
    GO:0003677DNA binding ISS--
    GO:0003682chromatin binding IEA--
         
    Find genes that share ontologies with EOMES           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for EOMES:
     Decreased Hepatitis C virus re 

         13 MGI mutant phenotypes (inferred from 11 alleles(MGI details for Eomes):
     behavior/neurological  cellular  embryogenesis  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  nervous system  no phenotypic analysis  normal 
     reproductive system  tumorigenesis  vision/eye 

    Find genes that share phenotypes with EOMES           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for EOMES: Eomestm1.1Rob Eomestm1.1Whk Eomestm1Jrt

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EOMES
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EOMES

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EOMES
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EOMES

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  ATTAACACCT 

    miRNA
    Products:
        
    miRTarBase miRNAs that target EOMES:
    hsa-mir-106b-5p (MIRT006568)

    Block miRNA regulation of human, mouse, rat EOMES using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EOMES (see all 22):
    hsa-miR-25 hsa-miR-1271 hsa-miR-3190 hsa-miR-103a hsa-miR-1184 hsa-miR-3613-3p hsa-miR-92b hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidEOMES 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EOMES
    Predesigned siRNA for gene silencing in human, mouse, rat EOMES

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EOMES

    Clone
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    OriGene clones in human, mouse for EOMES (see all 7)
    OriGene ORF clones in mouse, rat for EOMES
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EOMES (NM_005442)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EOMES
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat EOMES

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for EOMES 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EOMES

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA4-13421) for EOMES 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EOMES_HUMAN, O95936: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with EOMES           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EOMES About    
    See pathways by source

    SuperPathContained pathways About
    1IL12-mediated signaling events
    IL12-mediated signaling events0.33
    2Transcriptional Regulatory Network in Embryonic Stem Cell
    Transcriptional Regulatory Network in Embryonic Stem Cell
    3Selected targets of Oct 3 4
    Selected targets of Oct 3 4
    4Downstream signaling in naive CD8+ T cells
    Downstream signaling in naive CD8+ T cells

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for EOMES
        Transcriptional Regulatory Network in Embryonic Stem Cell

    2 BioSystems Pathways for EOMES
        IL12-mediated signaling events
    Downstream signaling in naive CD8+ T cells


        Pathway & Disease-focused RT2 Profiler PCR Arrays including EOMES: 
              Embryonic Stem Cells in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for EOMES

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for EOMES (O959362, 3 ENSP000002957434) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PFDN1O609252, 3MINT-8265808 I2D: score=2 
    CD247ENSP000003547824STRING: ENSP00000354782
    CD3DENSP000003006924STRING: ENSP00000300692
    CD3EENSP000003545664STRING: ENSP00000354566
    CD3GENSP000002921444STRING: ENSP00000292144
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001706endoderm formation ISS--
    GO:0001707mesoderm formation ISS--
    GO:0001714endodermal cell fate specification IEA--
    GO:0001824blastocyst development ----

    Find genes that share ontologies with EOMES           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EOMES



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EOMES gene (3 alternative transcripts): 
    NM_001278182.1  NM_001278183.1  NM_005442.3  

    Unigene Cluster for EOMES:

    Eomesodermin
    Hs.591663  [show with all ESTs]
    Unigene Representative Sequence: BC037568
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295743(uc003cdx.3) ENST00000449599(uc003cdy.3 uc010hfn.2)
    ENST00000461503 ENST00000537516(uc011axc.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EOMES using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EOMES (see all 22):
    hsa-miR-25 hsa-miR-1271 hsa-miR-3190 hsa-miR-103a hsa-miR-1184 hsa-miR-3613-3p hsa-miR-92b hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidEOMES 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EOMES
    Clone
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    OriGene ORF clones in mouse, rat for EOMES
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EOMES (NM_005442)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EOMES
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat EOMES
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for EOMES
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EOMES
      QuantiTect SYBR Green Assays in human, mouse, rat EOMES
      QuantiFast Probe-based Assays in human, mouse, rat EOMES
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA4-13421) for EOMES 

    Additional mRNA sequence: 

    AB031038.1 AK297389.1 AK297461.1 AK299499.1 AK299695.1 AK316166.1 BC025363.1 BC037568.1 
    BC131712.1 

    4 DOTS entries:

    DT.100017509  DT.310429  DT.120840460  DT.120840453 

    Selected AceView cDNA sequences (see all 32):

    AA323074 NM_005442 AA332234 AA325492 BX096900 AA331172 BC025363 BM720063 
    BX090438 AA331173 AA331789 AI206727 BI838165 CA440210 BC037568 AA333545 
    AW002985 AA361385 AA083564 AA083565 AW795410 AW965242 AW963541 AA333532 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for EOMES    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:                                                      
    SP2:                                            -         
    SP3:        -                                             


    ECgene alternative splicing isoforms for EOMES

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    EOMES expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGCCCTAG
    EOMES Expression
    About this image


    EOMES expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 9 entries
             Trophoblast Cells Trophoblast
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 7 entries
             2-Cell Embryo Zygote
     
     Zygote (Early Embryonic Tissues)    fully expand to see all 6 entries
             2-Cell Embryo Zygote
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 8 entries
             Primitive Streak Cells Anterior Primitive Streak
             Mesendoderm-like cells
     
     Epiblast (Early Embryo)    fully expand to see all 5 entries
             Primitive Streak Cells Anterior Primitive Streak
             Epiblast Stem Cell line 5
    EOMES Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EOMES Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591663

    UniProtKB/Swiss-Prot: EOMES_HUMAN, O95936
    Tissue specificity: Expressed in CD8+ T-cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EOMES: 
              Embryonic Stem Cells in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for EOMES
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EOMES
    QuantiTect SYBR Green Assays in human, mouse, rat EOMES
    QuantiFast Probe-based Assays in human, mouse, rat EOMES
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EOMES

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for EOMES gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eomes1 , 5 eomesodermin homolog (Xenopus laevis)1, 5 86.99(n)1
    91.54(a)1
      9 (70.21 cM)5
    138131  NM_010136.31  NP_034266.21 
     1184782125 
    chicken
    (Gallus gallus)
    Aves EOMES1 eomesodermin 77.26(n)
    81.33(a)
      428443  XM_004939419.1  XP_004939476.1 
    lizard
    (Anolis carolinensis)
    Reptilia EOMES6
    eomesodermin
    84(a)
    1 ↔ 1
    1(196231800-196243975)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980652 eomesodermin 76.2(n)    U75996.1 
    zebrafish
    (Danio rerio)
    Actinopterygii eomes2 eomesodermin homolog 75.5(n)   64603  AF329830.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tbx-93 Brachyury 41(a)
    (best of 2)
      III(10411723-10415490)   --


    ENSEMBL Gene Tree for EOMES (if available)
    TreeFam Gene Tree for EOMES (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EOMES gene
    TBR12  TBX212  MGA2  
    6 SIMAP similar genes for EOMES using alignment to 3 protein entries:     EOMES_HUMAN (see all proteins):
    TBR1    TBX18    TBX6    TBX10    TBX21    T

    Find genes that share paralogs with EOMES           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EOMES (see all 220)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360694
    A breast cancer sample4--see VAR_0360692 E Q mis40--------
    rs23711081,2
    C,F--27757018(+) GATGGG/TTGGCC 3 -- ds50018Minor allele frequency- T:0.49NA CSA WA EA 368
    rs28879431,2
    C,H--27757152(+) GCAATC/TTTCCC 3 -- ds50012Minor allele frequency- T:0.00NS NA 228
    rs1890990211,2
    --27757381(+) GGAAGC/GAAAAT 3 -- ds50010--------
    rs10788481,2
    C,F,H--27757392(-) TTAAAG/TATCTC 3 -- ds500114Minor allele frequency- T:0.04NS EA NA CSA 1827
    rs1824888511,2
    --27757448(+) GTTCCA/CTTACT 3 -- ut310--------
    rs1388594511,2
    --27757533(+) GTATCA/TGGTTT 3 -- ut310--------
    rs1871658561,2
    --27757582(+) CGCAAC/GAAGAG 3 -- ut310--------
    rs1427923951,2
    --27757717(+) TGCCCC/TTGCAG 3 -- ut310--------
    rs113752601,2
    C--27757867(+) CTCCC-/TTTTTT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for EOMES (27757440 - 27764206 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for EOMES: --
    Human Gene Mutation Database (HGMD): EOMES
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EOMES
    DNA2.0 Custom Variant and Variant Library Synthesis for EOMES

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604615    OMIM disorders: --

    UniProtKB/Swiss-Prot: EOMES_HUMAN, O95936
  • Note=A translocation t(3;10)(p24;q23) located 215 kb 3' to the EOMES gene but leading to loss of its
    expression was identified in a large consanguineous family. Homozygous silencing produces microcephaly associated
    with corpus callosum agenesis, bilateral polymicrogyria, ventricular dilatation and a small cerebellum

  • 2 diseases for EOMES:    
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    microcephaly - polymicrogyria - corpus callosum agenesis    corpus callosum agenesis


    Find genes that share disorders with EOMES           About GenesLikeMe

    Genetic Association Database (GAD): EOMES

    Export disorders for EOMES gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EOMES gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with EOMES)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19. (PubMed id 9888994)1, 2, 3, 9 Yi C.-H.... Brook J.D. (Genomics 1999)
    2. The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer. (PubMed id 17566017)1, 2, 9 Atreya I.... Neurath M.F. (Gut 2007)
    3. Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis. (PubMed id 17353897)1, 2, 9 Baala L.... Lyonnet S. (Nat. Genet. 2007)
    4. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. (PubMed id 22190364)1, 4 Patsopoulos N.A....de Bakker P.I. (Ann. Neurol. 2011)
    5. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (Nature 2011)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain. (PubMed id 10407135)1, 2 Kimura N.... Taga T. (Brain Res. Dev. Brain Res. 1999)
    8. [Role of transcription factor T-bet and Eomes in IFN-gamma secretion of different human T cell subsets]. (PubMed id 20056084)1, 9 Wang H.T....Li B.Q. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010)
    9. Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B). (PubMed id 18523274)1, 9 Araki Y....Weng N.P. (J. Immunol. 2008)
    10. Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin. (PubMed id 20498708)1, 9 Narayanan S....Borrego F. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8320 HGNC: 3372 AceView: EOMES Ensembl:ENSG00000163508 euGenes: HUgn8320
    ECgene: EOMES H-InvDB: EOMES

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EOMES Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EOMES gene:
    Search GeneIP for patents involving EOMES

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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