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Aliases for ENY2 Gene

Aliases for ENY2 Gene

  • Enhancer Of Yellow 2 Homolog (Drosophila) 2 3 5
  • Enhancer Of Yellow 2 Transcription Factor Homolog 3 4
  • E(Y)2 3
  • Sus1 3
  • DC6 3

External Ids for ENY2 Gene

Previous GeneCards Identifiers for ENY2 Gene

  • GC08P110416
  • GC08P110417
  • GC08P110346
  • GC08P105668

Summaries for ENY2 Gene

GeneCards Summary for ENY2 Gene

ENY2 (Enhancer Of Yellow 2 Homolog (Drosophila)) is a Protein Coding gene. Among its related pathways are Chromatin organization. GO annotations related to this gene include transcription coactivator activity and ligand-dependent nuclear receptor transcription coactivator activity.

UniProtKB/Swiss-Prot for ENY2 Gene

  • Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENY2 Gene

Genomics for ENY2 Gene

Regulatory Elements for ENY2 Gene

Enhancers for ENY2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ENY2 on UCSC Golden Path with GeneCards custom track

Promoters for ENY2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ENY2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ENY2 Gene

Chromosome:
8
Start:
109,334,323 bp from pter
End:
109,345,960 bp from pter
Size:
11,638 bases
Orientation:
Plus strand

Genomic View for ENY2 Gene

Genes around ENY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENY2 Gene

Proteins for ENY2 Gene

  • Protein details for ENY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPA8-ENY2_HUMAN
    Recommended name:
    Transcription and mRNA export factor ENY2
    Protein Accession:
    Q9NPA8
    Secondary Accessions:
    • B2RE52
    • G3V117

    Protein attributes for ENY2 Gene

    Size:
    101 amino acids
    Molecular mass:
    11529 Da
    Quaternary structure:
    • Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II.

    Three dimensional structures from OCA and Proteopedia for ENY2 Gene

    Alternative splice isoforms for ENY2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENY2 Gene

Proteomics data for ENY2 Gene at MOPED

Post-translational modifications for ENY2 Gene

  • Ubiquitination at Lys 19 and Lys 74
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ENY2 Gene

Domains & Families for ENY2 Gene

Gene Families for ENY2 Gene

Protein Domains for ENY2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ENY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPA8

UniProtKB/Swiss-Prot:

ENY2_HUMAN :
  • Belongs to the ENY2 family.
Family:
  • Belongs to the ENY2 family.
genes like me logo Genes that share domains with ENY2: view

Function for ENY2 Gene

Molecular function for ENY2 Gene

UniProtKB/Swiss-Prot Function:
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
genes like me logo Genes that share phenotypes with ENY2: view

Animal Model Products

miRNA for ENY2 Gene

miRTarBase miRNAs that target ENY2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENY2 Gene

Localization for ENY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENY2 Gene

Nucleus, nucleoplasm. Nucleus, nuclear pore complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ENY2 Gene COMPARTMENTS Subcellular localization image for ENY2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ENY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IDA 18206972
GO:0071819 DUBm complex IEA,IBA --
genes like me logo Genes that share ontologies with ENY2: view

Pathways & Interactions for ENY2 Gene

genes like me logo Genes that share pathways with ENY2: view

Pathways by source for ENY2 Gene

Gene Ontology (GO) - Biological Process for ENY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter IEA --
GO:0006406 mRNA export from nucleus IEA --
GO:0016578 histone deubiquitination IEA,IDA 18206972
genes like me logo Genes that share ontologies with ENY2: view

No data available for SIGNOR curated interactions for ENY2 Gene

Drugs & Compounds for ENY2 Gene

No Compound Related Data Available

Transcripts for ENY2 Gene

Unigene Clusters for ENY2 Gene

Enhancer of yellow 2 homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ENY2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10: - - - -
SP11: - - - -
SP12: - - - -
SP13: -
SP14: -

Relevant External Links for ENY2 Gene

GeneLoc Exon Structure for
ENY2
ECgene alternative splicing isoforms for
ENY2

Expression for ENY2 Gene

mRNA expression in normal human tissues for ENY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ENY2 Gene

This gene is overexpressed in Tlymphocyte (9.4), Peripheral blood mononuclear cells (6.9), Ovary (6.8), and Bone (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ENY2 Gene



SOURCE GeneReport for Unigene cluster for ENY2 Gene Hs.492555

genes like me logo Genes that share expression patterns with ENY2: view

Protein tissue co-expression partners for ENY2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ENY2 Gene

Orthologs for ENY2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ENY2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ENY2 35
  • 99.01 (n)
  • 100 (a)
ENY2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ENY2 35
  • 99.34 (n)
  • 100 (a)
ENY2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eny2 35
  • 98.02 (n)
  • 100 (a)
Eny2 16
Eny2 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ENY2 35
  • 99.67 (n)
  • 100 (a)
ENY2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eny2 35
  • 98.02 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia ENY2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ENY2 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ENY2 35
  • 88.54 (n)
  • 95.83 (a)
ENY2 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 94 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia eny2 35
  • 78.12 (n)
  • 93.75 (a)
Str.821 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8036 35
zebrafish
(Danio rerio)
Actinopterygii eny2 35
  • 74.74 (n)
  • 85.26 (a)
eny2 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta e(y)2 36
  • 41 (a)
OneToMany
e(y)2b 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G27100 35
  • 59.85 (n)
  • 56.82 (a)
rice
(Oryza sativa)
Liliopsida Os01g0920200 35
  • 56.38 (n)
  • 58.51 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4647 35
Species with no ortholog for ENY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ENY2 Gene

ENSEMBL:
Gene Tree for ENY2 (if available)
TreeFam:
Gene Tree for ENY2 (if available)

Paralogs for ENY2 Gene

Pseudogenes.org Pseudogenes for ENY2 Gene

genes like me logo Genes that share paralogs with ENY2: view

No data available for Paralogs for ENY2 Gene

Variants for ENY2 Gene

Sequence variations from dbSNP and Humsavar for ENY2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs9297424 -- 109,345,080(+) TTTCT(C/G)ATATG nc-transcript-variant, utr-variant-3-prime
rs2926239 -- 109,346,443(-) GGCAG(A/G)TTCAT downstream-variant-500B
rs2926240 -- 109,345,839(-) TCTCA(C/G)CACTA nc-transcript-variant, utr-variant-3-prime
rs2926241 -- 109,344,503(-) CCATA(C/G)CAGTT nc-transcript-variant, utr-variant-3-prime
rs2926242 -- 109,337,586(-) CTAAA(A/C)TATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENY2 Gene

Variant ID Type Subtype PubMed ID
dgv7843n71 CNV Loss 21882294
nsv891280 CNV Loss 21882294
esv270816 CNV Insertion 20981092
esv273620 CNV Insertion 20981092

Variation tolerance for ENY2 Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENY2 Gene

HapMap Linkage Disequilibrium report
ENY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENY2 Gene

Disorders for ENY2 Gene

Relevant External Links for ENY2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ENY2

No disorders were found for ENY2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENY2 Gene

Publications for ENY2 Gene

  1. The novel transcription factor e(y)2 interacts with TAF(II)40 and potentiates transcription activation on chromatin templates. (PMID: 11438676) Georgieva S. … Soldatov A. (Mol. Cell. Biol. 2001) 2 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for ENY2 Gene

Sources for ENY2 Gene

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