Aliases for ENY2 Gene
External Ids for ENY2 Gene
Previous GeneCards Identifiers for ENY2 Gene
GeneCards Summary for ENY2 Gene
ENY2 (ENY2, Transcription And Export Complex 2 Subunit) is a Protein Coding gene. Diseases associated with ENY2 include Warsaw Breakage Syndrome. Among its related pathways are Chromatin organization. GO annotations related to this gene include transcription coactivator activity and ligand-dependent nuclear receptor transcription coactivator activity.
UniProtKB/Swiss-Prot for ENY2 Gene
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.