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Aliases for ENTPD8 Gene

Aliases for ENTPD8 Gene

  • Ectonucleoside Triphosphate Diphosphohydrolase 8 2 3
  • E-NTPDase 8 3 4
  • EC 3.6.1.5 4 63
  • GLSR2492 2 3
  • Liver Ecto-ATP-Diphosphohydrolase 3
  • E-NTPDase 3
  • NTPDase-8 3
  • NTPDase 8 4
  • NTPDase8 4
  • EC 3.6.1 63
  • UNQ2492 3

External Ids for ENTPD8 Gene

Previous GeneCards Identifiers for ENTPD8 Gene

  • GC17M077585
  • GC09M137604
  • GC09M139448
  • GC09M140328
  • GC09M109793

Summaries for ENTPD8 Gene

GeneCards Summary for ENTPD8 Gene

ENTPD8 (Ectonucleoside Triphosphate Diphosphohydrolase 8) is a Protein Coding gene. Among its related pathways are Epstein-Barr virus infection and Pyrimidine metabolism (KEGG). GO annotations related to this gene include hydrolase activity and nucleoside-diphosphatase activity. An important paralog of this gene is ENTPD4.

UniProtKB/Swiss-Prot for ENTPD8 Gene

  • Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENTPD8 Gene

Genomics for ENTPD8 Gene

Regulatory Elements for ENTPD8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ENTPD8 Gene

Chromosome:
9
Start:
137,434,364 bp from pter
End:
137,441,816 bp from pter
Size:
7,453 bases
Orientation:
Minus strand

Genomic View for ENTPD8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ENTPD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENTPD8 Gene

Proteins for ENTPD8 Gene

  • Protein details for ENTPD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MY95-ENTP8_HUMAN
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 8
    Protein Accession:
    Q5MY95
    Secondary Accessions:
    • A2BG17
    • Q6UVZ0

    Protein attributes for ENTPD8 Gene

    Size:
    495 amino acids
    Molecular mass:
    53904 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Ca(2+) or Mg(2+). Has lower efficiency with Mg(2+).;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ENTPD8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENTPD8 Gene

Proteomics data for ENTPD8 Gene at MOPED

Selected DME Specific Peptides for ENTPD8 Gene

Post-translational modifications for ENTPD8 Gene

Other Protein References for ENTPD8 Gene

Antibody Products

Domains & Families for ENTPD8 Gene

Protein Domains for ENTPD8 Gene

Suggested Antigen Peptide Sequences for ENTPD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5MY95

UniProtKB/Swiss-Prot:

ENTP8_HUMAN :
  • The transmembranous domains are involved in regulation of enzyme activity.
  • Belongs to the GDA1/CD39 NTPase family.
Domain:
  • The transmembranous domains are involved in regulation of enzyme activity.
Family:
  • Belongs to the GDA1/CD39 NTPase family.
genes like me logo Genes that share domains with ENTPD8: view

No data available for Gene Families for ENTPD8 Gene

Function for ENTPD8 Gene

Molecular function for ENTPD8 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=81 uM for ATP {ECO:0000269 PubMed:17095758}; KM=137 uM for ADP {ECO:0000269 PubMed:17095758}; KM=480 uM for UTP {ECO:0000269 PubMed:17095758}; KM=241 uM for UDP {ECO:0000269 PubMed:17095758}; Vmax=790 nmol/min/mg enzyme with ATP as substrate {ECO:0000269 PubMed:17095758}; Vmax=163 nmol/min/mg enzyme with ADP as substrate {ECO:0000269 PubMed:17095758}; Vmax=1100 nmol/min/mg enzyme with UTP as substrate {ECO:0000269 PubMed:17095758}; Vmax=110 nmol/min/mg enzyme with UDP as substrate {ECO:0000269 PubMed:17095758};
UniProtKB/Swiss-Prot CatalyticActivity:
A nucleoside 5-triphosphate + 2 H(2)O = a nucleoside 5-phosphate + 2 phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Not inhibited by ARL 67156.
UniProtKB/Swiss-Prot Function:
Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP.

Enzyme Numbers (IUBMB) for ENTPD8 Gene

Gene Ontology (GO) - Molecular Function for ENTPD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity --
GO:0017110 nucleoside-diphosphatase activity IEA --
GO:0017111 nucleoside-triphosphatase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ENTPD8: view

Phenotypes for ENTPD8 Gene

genes like me logo Genes that share phenotypes with ENTPD8: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENTPD8

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENTPD8 Gene

Localization for ENTPD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENTPD8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ENTPD8 Gene COMPARTMENTS Subcellular localization image for ENTPD8 gene
Compartment Confidence
plasma membrane 3
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ENTPD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ENTPD8: view

Pathways & Interactions for ENTPD8 Gene

genes like me logo Genes that share pathways with ENTPD8: view

Pathways by source for ENTPD8 Gene

Interacting Proteins for ENTPD8 Gene

Gene Ontology (GO) - Biological Process for ENTPD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0009124 nucleoside monophosphate biosynthetic process IEA --
GO:0009133 nucleoside diphosphate biosynthetic process IEA --
genes like me logo Genes that share ontologies with ENTPD8: view

No data available for SIGNOR curated interactions for ENTPD8 Gene

Drugs & Compounds for ENTPD8 Gene

(13) Drugs for ENTPD8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
5-Thymidylic acid Experimental Pharma 0
CDP Experimental Pharma 0
Cytidine triphosphate Experimental Pharma 0

(10) Additional Compounds for ENTPD8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
63-37-6
dTDP
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
491-97-4
IDP
  • 5'-IDP
  • IDP
  • Inosine 5'-(trihydrogen diphosphate)
  • Inosine 5'-(trihydrogen pyrophosphate)
  • Inosine 5'-diphosphate
86-04-4
inosine triphosphate
  • 2'-Inosine-5'-triphosphate
  • 5'-ITP
  • 5-ITP
  • Inosine 5
  • Inosine 5'-(tetrahydrogen triphosphate)
132-06-9
genes like me logo Genes that share compounds with ENTPD8: view

Transcripts for ENTPD8 Gene

Unigene Clusters for ENTPD8 Gene

Ectonucleoside triphosphate diphosphohydrolase 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENTPD8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD8 Gene

No ASD Table

Relevant External Links for ENTPD8 Gene

GeneLoc Exon Structure for
ENTPD8
ECgene alternative splicing isoforms for
ENTPD8

Expression for ENTPD8 Gene

mRNA expression in normal human tissues for ENTPD8 Gene

mRNA differential expression in normal tissues according to GTEx for ENTPD8 Gene

This gene is overexpressed in Colon - Transverse (x20.4), Small Intestine - Terminal Ileum (x10.4), and Liver (x5.7).

Protein differential expression in normal tissues from HIPED for ENTPD8 Gene

This gene is overexpressed in Pancreatic juice (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ENTPD8 Gene



SOURCE GeneReport for Unigene cluster for ENTPD8 Gene Hs.512562

genes like me logo Genes that share expression patterns with ENTPD8: view

Protein tissue co-expression partners for ENTPD8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ENTPD8 Gene

Orthologs for ENTPD8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ENTPD8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ENTPD8 35
  • 81.04 (n)
  • 77.33 (a)
ENTPD8 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ENTPD8 35
  • 79.74 (n)
  • 74.39 (a)
ENTPD8 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Entpd8 35
  • 78.61 (n)
  • 74.49 (a)
Entpd8 16
Entpd8 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ENTPD8 35
  • 99.19 (n)
  • 98.59 (a)
ENTPD8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Entpd8 35
  • 79.82 (n)
  • 75.1 (a)
oppossum
(Monodelphis domestica)
Mammalia ENTPD8 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ENTPD8 36
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves ENTPD8L 35
  • 62.72 (n)
  • 54.55 (a)
-- 36
  • 50 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
ENTPD8 36
  • 52 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ENTPD8 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia entpd8 35
  • 62.93 (n)
  • 54.26 (a)
zebrafish
(Danio rerio)
Actinopterygii entpd8 35
  • 53.41 (n)
  • 48.17 (a)
entpd8 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mig-23 36
  • 19 (a)
ManyToMany
ntp-1 36
  • 20 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YND1 36
  • 17 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G19180 35
  • 41.38 (n)
  • 31.83 (a)
rice
(Oryza sativa)
Liliopsida Os10g0350500 35
  • 39.58 (n)
  • 31.39 (a)
Species with no ortholog for ENTPD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENTPD8 Gene

ENSEMBL:
Gene Tree for ENTPD8 (if available)
TreeFam:
Gene Tree for ENTPD8 (if available)

Paralogs for ENTPD8 Gene

Paralogs for ENTPD8 Gene

(3) SIMAP similar genes for ENTPD8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ENTPD8: view

Variants for ENTPD8 Gene

Sequence variations from dbSNP and Humsavar for ENTPD8 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs6606582 - 137,438,026(+) TCGCC(A/G)GCCAC missense, reference, intron-variant
rs9414731 -- 137,437,381(+) AAGAC(A/G)TGACC intron-variant
rs9695611 -- 137,439,088(+) CCTAG(A/G)AAGCC intron-variant, upstream-variant-2KB
rs9722391 -- 137,439,407(+) GTCCC(A/G)GCACC intron-variant, upstream-variant-2KB
rs11507673 -- 137,441,903(+) AGGCG(C/T)GGAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ENTPD8 Gene

Variant ID Type Subtype PubMed ID
nsv894387 CNV Gain 21882294
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
dgv8445n71 CNV Loss 21882294
dgv8454n71 CNV Gain 21882294
dgv8455n71 CNV Gain+Loss 21882294
nsv894645 CNV Loss 21882294
dgv2428e1 CNV Complex 17122850
nsv894653 CNV Gain 21882294
dgv8460n71 CNV Loss 21882294
nsv894657 CNV Loss 21882294
nsv894658 CNV Loss 21882294
nsv894659 CNV Loss 21882294
nsv894660 CNV Loss 21882294
nsv6771 CNV Insertion 18451855
dgv8461n71 CNV Loss 21882294
esv2739446 CNV Deletion 23290073
esv2739447 CNV Deletion 23290073
esv2657589 CNV Deletion 23128226
esv26196 CNV Loss 19812545
esv2739448 CNV Deletion 23290073

Variation tolerance for ENTPD8 Gene

Residual Variation Intolerance Score: 78.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.11; 61.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENTPD8 Gene

HapMap Linkage Disequilibrium report
ENTPD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENTPD8 Gene

Disorders for ENTPD8 Gene

Relevant External Links for ENTPD8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ENTPD8
genes like me logo Genes that share disorders with ENTPD8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENTPD8 Gene

Publications for ENTPD8 Gene

  1. The stability of chicken nucleoside triphosphate diphosphohydrolase 8 requires both of its transmembrane domains. (PMID: 20000380) Li C.S. … Knowles A.F. (Biochemistry 2010) 23 67
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 67
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  4. Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8. (PMID: 17095758) Fausther M. … Sevigny J. (Am. J. Physiol. 2007) 67
  5. Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists. (PMID: 17727821) Munkonda M.N. … SAcvigny J. (Biochem. Pharmacol. 2007) 67

Products for ENTPD8 Gene

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