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Aliases for ENTPD7 Gene

Aliases for ENTPD7 Gene

  • Ectonucleoside Triphosphate Diphosphohydrolase 7 2 3 5
  • Lysosomal Apyrase-Like Protein 1 3 4
  • NTPDase 7 3 4
  • LALP1 3 4
  • EC 3.6.1.6 61
  • EC 3.6.1.- 4
  • EC 3.6.1 61

External Ids for ENTPD7 Gene

Previous GeneCards Identifiers for ENTPD7 Gene

  • GC10P101084
  • GC10P101409
  • GC10P095046

Summaries for ENTPD7 Gene

GeneCards Summary for ENTPD7 Gene

ENTPD7 (Ectonucleoside Triphosphate Diphosphohydrolase 7) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ENTPD4.

UniProtKB/Swiss-Prot for ENTPD7 Gene

  • Preferentially hydrolyzes nucleoside 5-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENTPD7 Gene

Genomics for ENTPD7 Gene

Regulatory Elements for ENTPD7 Gene

Enhancers for ENTPD7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ENTPD7 on UCSC Golden Path with GeneCards custom track

Promoters for ENTPD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ENTPD7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ENTPD7 Gene

Chromosome:
10
Start:
99,659,506 bp from pter
End:
99,711,245 bp from pter
Size:
51,740 bases
Orientation:
Plus strand

Genomic View for ENTPD7 Gene

Genes around ENTPD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENTPD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENTPD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENTPD7 Gene

Proteins for ENTPD7 Gene

  • Protein details for ENTPD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQZ7-ENTP7_HUMAN
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 7
    Protein Accession:
    Q9NQZ7
    Secondary Accessions:
    • B2RB83
    • B3KP21
    • D3DR64

    Protein attributes for ENTPD7 Gene

    Size:
    604 amino acids
    Molecular mass:
    68960 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for ENTPD7 Gene

Post-translational modifications for ENTPD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ENTPD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ENTPD7 Gene

Protein Domains for ENTPD7 Gene

Suggested Antigen Peptide Sequences for ENTPD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQZ7

UniProtKB/Swiss-Prot:

ENTP7_HUMAN :
  • Belongs to the GDA1/CD39 NTPase family.
Family:
  • Belongs to the GDA1/CD39 NTPase family.
genes like me logo Genes that share domains with ENTPD7: view

No data available for Gene Families for ENTPD7 Gene

Function for ENTPD7 Gene

Molecular function for ENTPD7 Gene

UniProtKB/Swiss-Prot Function:
Preferentially hydrolyzes nucleoside 5-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP.

Enzyme Numbers (IUBMB) for ENTPD7 Gene

Gene Ontology (GO) - Molecular Function for ENTPD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ENTPD7: view
genes like me logo Genes that share phenotypes with ENTPD7: view

Animal Models for ENTPD7 Gene

MGI Knock Outs for ENTPD7:

Animal Model Products

  • Taconic Biosciences Mouse Models for ENTPD7

CRISPR Products

miRNA for ENTPD7 Gene

miRTarBase miRNAs that target ENTPD7

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ENTPD7 Gene

Localization for ENTPD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENTPD7 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localizes to intracellular vesicular compartments. {ECO:0000269 PubMed:11278936}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ENTPD7 Gene COMPARTMENTS Subcellular localization image for ENTPD7 gene
Compartment Confidence
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ENTPD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with ENTPD7: view

Pathways & Interactions for ENTPD7 Gene

SuperPathways for ENTPD7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ENTPD7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ENTPD7 Gene

Drugs & Compounds for ENTPD7 Gene

(2) Drugs for ENTPD7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
calcium Nutra 0
genes like me logo Genes that share compounds with ENTPD7: view

Transcripts for ENTPD7 Gene

mRNA/cDNA for ENTPD7 Gene

Unigene Clusters for ENTPD7 Gene

Ectonucleoside triphosphate diphosphohydrolase 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2:
SP3:

Relevant External Links for ENTPD7 Gene

GeneLoc Exon Structure for
ENTPD7
ECgene alternative splicing isoforms for
ENTPD7

Expression for ENTPD7 Gene

mRNA expression in normal human tissues for ENTPD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ENTPD7 Gene



NURSA nuclear receptor signaling pathways regulating expression of ENTPD7 Gene:

ENTPD7

SOURCE GeneReport for Unigene cluster for ENTPD7 Gene:

Hs.744948
genes like me logo Genes that share expression patterns with ENTPD7: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ENTPD7 Gene

Orthologs for ENTPD7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ENTPD7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100300490 34
  • 92.57 (n)
  • 95.64 (a)
ENTPD7 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ENTPD7 34
  • 93.16 (n)
  • 96.69 (a)
ENTPD7 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Entpd7 34
  • 87.2 (n)
  • 92.38 (a)
Entpd7 16
Entpd7 35
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ENTPD7 34
  • 99.67 (n)
  • 99.5 (a)
ENTPD7 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Entpd7 34
  • 87.31 (n)
  • 93.81 (a)
oppossum
(Monodelphis domestica)
Mammalia ENTPD7 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ENTPD7 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ENTPD7 34
  • 69.48 (n)
  • 74.7 (a)
ENTPD7 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ENTPD7 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia entpd7 34
  • 69.36 (n)
  • 70.54 (a)
worm
(Caenorhabditis elegans)
Secernentea ntp-1 34
  • 48.03 (n)
  • 39.68 (a)
mig-23 35
  • 32 (a)
ManyToMany
ntp-1 35
  • 34 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13662g 34
  • 45.15 (n)
  • 36.52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YND1 34
  • 46.63 (n)
  • 37.26 (a)
YND1 35
  • 26 (a)
OneToMany
YND1 37
rice
(Oryza sativa)
Liliopsida Os03g0378000 34
  • 45.28 (n)
  • 34.5 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08027 34
  • 46.59 (n)
  • 36.02 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ynd1 34
  • 48.93 (n)
  • 40.36 (a)
Species where no ortholog for ENTPD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ENTPD7 Gene

ENSEMBL:
Gene Tree for ENTPD7 (if available)
TreeFam:
Gene Tree for ENTPD7 (if available)

Paralogs for ENTPD7 Gene

Paralogs for ENTPD7 Gene

(1) SIMAP similar genes for ENTPD7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ENTPD7: view

Variants for ENTPD7 Gene

Sequence variations from dbSNP and Humsavar for ENTPD7 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11190245 - 99,691,502(+) CTCTG(C/T)CCTTC reference, missense
rs2013255 -- 99,693,309(-) CTTGG(A/G)TATCT intron-variant
rs2013269 -- 99,693,504(-) GTCCC(A/G)CTTGT intron-variant
rs2078260 -- 99,692,455(-) TGCAA(A/G)CTAAG intron-variant
rs3740078 -- 99,685,834(-) TCCAG(G/T)GGTAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ENTPD7 Gene

Variant ID Type Subtype PubMed ID
esv24363 CNV loss 19812545
esv2659605 CNV deletion 23128226
esv2675100 CNV deletion 23128226
esv3624350 CNV loss 21293372
esv3624351 CNV loss 21293372
nsv7516 CNV deletion 18451855

Variation tolerance for ENTPD7 Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.81; 79.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENTPD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ENTPD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENTPD7 Gene

Disorders for ENTPD7 Gene

Relevant External Links for ENTPD7

Genetic Association Database (GAD)
ENTPD7
Human Genome Epidemiology (HuGE) Navigator
ENTPD7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ENTPD7

No disorders were found for ENTPD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENTPD7 Gene

Publications for ENTPD7 Gene

  1. Molecular cloning and characterization of a novel mammalian endo- apyrase (LALP1). (PMID: 11278936) Shi J.-D. … She J.-X. (J. Biol. Chem. 2001) 2 3 4 22 65
  2. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. (PMID: 20534741) Corneveaux J.J. … Huentelman M.J. (Hum. Mol. Genet. 2010) 3 46 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for ENTPD7 Gene

Sources for ENTPD7 Gene

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