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Aliases for ENTPD7 Gene

Aliases for ENTPD7 Gene

  • Ectonucleoside Triphosphate Diphosphohydrolase 7 2 3 5
  • Lysosomal Apyrase-Like Protein 1 3 4
  • NTPDase 7 3 4
  • LALP1 3 4
  • EC 63
  • EC 3.6.1.- 4
  • EC 3.6.1 63

External Ids for ENTPD7 Gene

Previous GeneCards Identifiers for ENTPD7 Gene

  • GC10P101084
  • GC10P101409
  • GC10P095046

Summaries for ENTPD7 Gene

GeneCards Summary for ENTPD7 Gene

ENTPD7 (Ectonucleoside Triphosphate Diphosphohydrolase 7) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ENTPD3.

UniProtKB/Swiss-Prot for ENTPD7 Gene

  • Preferentially hydrolyzes nucleoside 5-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENTPD7 Gene

Genomics for ENTPD7 Gene

Regulatory Elements for ENTPD7 Gene

Enhancers for ENTPD7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ENTPD7 on UCSC Golden Path with GeneCards custom track

Promoters for ENTPD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ENTPD7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ENTPD7 Gene

99,659,506 bp from pter
99,711,245 bp from pter
51,740 bases
Plus strand

Genomic View for ENTPD7 Gene

Genes around ENTPD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENTPD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENTPD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENTPD7 Gene

Proteins for ENTPD7 Gene

  • Protein details for ENTPD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 7
    Protein Accession:
    Secondary Accessions:
    • B2RB83
    • B3KP21
    • D3DR64

    Protein attributes for ENTPD7 Gene

    604 amino acids
    Molecular mass:
    68960 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for ENTPD7 Gene

Proteomics data for ENTPD7 Gene at MOPED

Post-translational modifications for ENTPD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ENTPD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ENTPD7 Gene

Protein Domains for ENTPD7 Gene

Suggested Antigen Peptide Sequences for ENTPD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GDA1/CD39 NTPase family.
  • Belongs to the GDA1/CD39 NTPase family.
genes like me logo Genes that share domains with ENTPD7: view

No data available for Gene Families for ENTPD7 Gene

Function for ENTPD7 Gene

Molecular function for ENTPD7 Gene

UniProtKB/Swiss-Prot Function:
Preferentially hydrolyzes nucleoside 5-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP.

Enzyme Numbers (IUBMB) for ENTPD7 Gene

genes like me logo Genes that share phenotypes with ENTPD7: view

Animal Models for ENTPD7 Gene

MGI Knock Outs for ENTPD7:

Animal Model Products

  • Taconic Biosciences Mouse Models for ENTPD7

CRISPR Products

miRNA for ENTPD7 Gene

miRTarBase miRNAs that target ENTPD7

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ENTPD7 Gene

Localization for ENTPD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENTPD7 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localizes to intracellular vesicular compartments. {ECO:0000269 PubMed:11278936}.

Subcellular locations from

Jensen Localization Image for ENTPD7 Gene COMPARTMENTS Subcellular localization image for ENTPD7 gene
Compartment Confidence
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ENTPD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ENTPD7: view

Pathways & Interactions for ENTPD7 Gene

SuperPathways for ENTPD7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ENTPD7 Gene


No data available for Pathways by source and SIGNOR curated interactions for ENTPD7 Gene

Drugs & Compounds for ENTPD7 Gene

(2) Drugs for ENTPD7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
calcium Nutra 0
genes like me logo Genes that share compounds with ENTPD7: view

Transcripts for ENTPD7 Gene

mRNA/cDNA for ENTPD7 Gene

Unigene Clusters for ENTPD7 Gene

Ectonucleoside triphosphate diphosphohydrolase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -

Relevant External Links for ENTPD7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ENTPD7 Gene

mRNA expression in normal human tissues for ENTPD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ENTPD7 Gene

SOURCE GeneReport for Unigene cluster for ENTPD7 Gene Hs.744948

genes like me logo Genes that share expression patterns with ENTPD7: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ENTPD7 Gene

Orthologs for ENTPD7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ENTPD7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100300490 35
  • 92.57 (n)
  • 95.64 (a)
  • 94 (a)
(Canis familiaris)
Mammalia ENTPD7 35
  • 93.16 (n)
  • 96.69 (a)
  • 97 (a)
(Mus musculus)
Mammalia Entpd7 35
  • 87.2 (n)
  • 92.38 (a)
Entpd7 16
Entpd7 36
  • 92 (a)
(Pan troglodytes)
Mammalia ENTPD7 35
  • 99.67 (n)
  • 99.5 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Entpd7 35
  • 87.31 (n)
  • 93.81 (a)
(Monodelphis domestica)
Mammalia ENTPD7 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia ENTPD7 36
  • 85 (a)
(Gallus gallus)
Aves ENTPD7 35
  • 69.48 (n)
  • 74.7 (a)
  • 72 (a)
(Anolis carolinensis)
Reptilia ENTPD7 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia entpd7 35
  • 69.36 (n)
  • 70.54 (a)
(Caenorhabditis elegans)
Secernentea ntp-1 35
  • 48.03 (n)
  • 39.68 (a)
mig-23 36
  • 32 (a)
ntp-1 36
  • 34 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13662g 35
  • 45.15 (n)
  • 36.52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YND1 35
  • 46.63 (n)
  • 37.26 (a)
YND1 36
  • 26 (a)
YND1 38
(Oryza sativa)
Liliopsida Os03g0378000 35
  • 45.28 (n)
  • 34.5 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08027 35
  • 46.59 (n)
  • 36.02 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ynd1 35
  • 48.93 (n)
  • 40.36 (a)
Species with no ortholog for ENTPD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ENTPD7 Gene

Gene Tree for ENTPD7 (if available)
Gene Tree for ENTPD7 (if available)

Paralogs for ENTPD7 Gene

Paralogs for ENTPD7 Gene

(1) SIMAP similar genes for ENTPD7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ENTPD7: view

Variants for ENTPD7 Gene

Sequence variations from dbSNP and Humsavar for ENTPD7 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11190245 - 99,691,502(+) CTCTG(C/T)CCTTC reference, missense
rs3047437 -- 99,692,542(+) TTTTT(-/T/TT)GCAGA intron-variant
rs3047439 -- 99,692,871(+) TTTTG(-/TGA)TGATG intron-variant
rs3740078 -- 99,685,834(-) TCCAG(G/T)GGTAA reference, synonymous-codon
rs3740079 -- 99,679,495(-) AGAGA(C/T)TGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENTPD7 Gene

Variant ID Type Subtype PubMed ID
esv2659605 CNV Deletion 23128226
nsv7516 CNV Loss 18451855
esv24363 CNV Loss 19812545
esv2675100 CNV Deletion 23128226

Variation tolerance for ENTPD7 Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.81; 79.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ENTPD7 Gene

Disorders for ENTPD7 Gene

Relevant External Links for ENTPD7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ENTPD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENTPD7 Gene

Publications for ENTPD7 Gene

  1. Molecular cloning and characterization of a novel mammalian endo- apyrase (LALP1). (PMID: 11278936) Shi J.-D. … She J.-X. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PMID: 22412388) Kenny E.E. … Peter I. (PLoS Genet. 2012) 3
  4. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. (PMID: 20534741) Corneveaux J.J. … Huentelman M.J. (Hum. Mol. Genet. 2010) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ENTPD7 Gene

Sources for ENTPD7 Gene