Aliases for ENTPD7 Gene
External Ids for ENTPD7 Gene
Previous GeneCards Identifiers for ENTPD7 Gene
This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. [provided by RefSeq, Mar 2017]
GeneCards Summary for ENTPD7 Gene
ENTPD7 (Ectonucleoside Triphosphate Diphosphohydrolase 7) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ENTPD4.
UniProtKB/Swiss-Prot for ENTPD7 Gene
Preferentially hydrolyzes nucleoside 5-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP.