Aliases for ENTPD7 Gene
External Ids for ENTPD7 Gene
Previous GeneCards Identifiers for ENTPD7 Gene
This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. [provided by RefSeq, Mar 2017]
GeneCards Summary for ENTPD7 Gene
ENTPD7 (Ectonucleoside Triphosphate Diphosphohydrolase 7) is a Protein Coding gene. Among its related pathways are Purine metabolism (REACTOME) and Metabolism. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ENTPD4.
UniProtKB/Swiss-Prot for ENTPD7 Gene
Preferentially hydrolyzes nucleoside 5-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP.