Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ENTPD6 Gene

Aliases for ENTPD6 Gene

  • Ectonucleoside Triphosphate Diphosphohydrolase 6 (Putative) 2 3 5
  • Interleukin 6 Signal Transducer-2 2 3
  • CD39 Antigen-Like 2 3 4
  • NTPDase 6 3 4
  • CD39L2 3 4
  • IL6ST2 3 4
  • Ectonucleoside Triphosphate Diphosphohydrolase 6 3
  • DJ738P15.3 3
  • EC 3.6.1.6 4
  • NTPDase-6 3
  • IL-6SAG 3

External Ids for ENTPD6 Gene

Previous HGNC Symbols for ENTPD6 Gene

  • CD39L2
  • IL6ST2

Previous GeneCards Identifiers for ENTPD6 Gene

  • GC20P025164
  • GC20P025171

Summaries for ENTPD6 Gene

Entrez Gene Summary for ENTPD6 Gene

  • ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

GeneCards Summary for ENTPD6 Gene

ENTPD6 (Ectonucleoside Triphosphate Diphosphohydrolase 6 (Putative)) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG). GO annotations related to this gene include hydrolase activity and nucleoside-diphosphatase activity. An important paralog of this gene is ENTPD5.

UniProtKB/Swiss-Prot for ENTPD6 Gene

  • Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5-diphosphates, nucleoside 5-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP (By similarity).

Gene Wiki entry for ENTPD6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENTPD6 Gene

Genomics for ENTPD6 Gene

Regulatory Elements for ENTPD6 Gene

Enhancers for ENTPD6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ENTPD6 on UCSC Golden Path with GeneCards custom track

Promoters for ENTPD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ENTPD6 Gene

Chromosome:
20
Start:
25,195,670 bp from pter
End:
25,226,729 bp from pter
Size:
31,060 bases
Orientation:
Plus strand

Genomic View for ENTPD6 Gene

Genes around ENTPD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENTPD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENTPD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENTPD6 Gene

Proteins for ENTPD6 Gene

  • Protein details for ENTPD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75354-ENTP6_HUMAN
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 6
    Protein Accession:
    O75354
    Secondary Accessions:
    • A6NCX6
    • D3DW49
    • Q5QPJ2
    • Q5QPJ5
    • Q7Z5B5
    • Q8N3H3
    • Q8TAS7
    • Q9UJD1

    Protein attributes for ENTPD6 Gene

    Size:
    484 amino acids
    Molecular mass:
    53246 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ENTPD6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENTPD6 Gene

Post-translational modifications for ENTPD6 Gene

  • Glycosylation at Ser 89, Asn 220, and Asn 284
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for ENTPD6 (CD39L2/ENTPD6)

No data available for DME Specific Peptides for ENTPD6 Gene

Domains & Families for ENTPD6 Gene

Protein Domains for ENTPD6 Gene

Graphical View of Domain Structure for InterPro Entry

O75354

UniProtKB/Swiss-Prot:

ENTP6_HUMAN :
  • Belongs to the GDA1/CD39 NTPase family.
Family:
  • Belongs to the GDA1/CD39 NTPase family.
genes like me logo Genes that share domains with ENTPD6: view

No data available for Gene Families for ENTPD6 Gene

Function for ENTPD6 Gene

Molecular function for ENTPD6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A nucleoside diphosphate + H(2)O = a nucleoside phosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5-diphosphates, nucleoside 5-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP (By similarity).

Enzyme Numbers (IUBMB) for ENTPD6 Gene

Gene Ontology (GO) - Molecular Function for ENTPD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008894 guanosine-5-triphosphate,3-diphosphate diphosphatase activity IEA --
GO:0017110 nucleoside-diphosphatase activity IEA --
GO:0017111 nucleoside-triphosphatase activity IEA --
GO:0045134 uridine-diphosphatase activity IEA --
genes like me logo Genes that share ontologies with ENTPD6: view
genes like me logo Genes that share phenotypes with ENTPD6: view

Animal Models for ENTPD6 Gene

MGI Knock Outs for ENTPD6:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ENTPD6 Gene

Localization for ENTPD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENTPD6 Gene

Golgi apparatus membrane; Single-pass type II membrane protein. Secreted. Note=But also occurs in a soluble extracellular form.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ENTPD6 Gene COMPARTMENTS Subcellular localization image for ENTPD6 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ENTPD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005615 extracellular space IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with ENTPD6: view

Pathways & Interactions for ENTPD6 Gene

genes like me logo Genes that share pathways with ENTPD6: view

Pathways by source for ENTPD6 Gene

2 KEGG pathways for ENTPD6 Gene
1 GeneGo (Thomson Reuters) pathway for ENTPD6 Gene

Gene Ontology (GO) - Biological Process for ENTPD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032026 response to magnesium ion IEA --
GO:0051592 response to calcium ion IEA --
genes like me logo Genes that share ontologies with ENTPD6: view

No data available for SIGNOR curated interactions for ENTPD6 Gene

Drugs & Compounds for ENTPD6 Gene

(10) Drugs for ENTPD6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
CDP Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0

(5) Additional Compounds for ENTPD6 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dTDP
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
491-97-4
IDP
  • 5'-IDP
  • IDP
  • Inosine 5'-(trihydrogen diphosphate)
  • Inosine 5'-(trihydrogen pyrophosphate)
  • Inosine 5'-diphosphate
86-04-4
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with ENTPD6: view

Transcripts for ENTPD6 Gene

Unigene Clusters for ENTPD6 Gene

Ectonucleoside triphosphate diphosphohydrolase 6 (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5:
SP6:
SP7: - - - - - - - -
SP8: - - -
SP9: - - - - - - -
SP10:
SP11: - - - - - -
SP12:
SP13: - - - -
SP14: - - -
SP15: - - -
SP16: - - - - - - - - - -
SP17: - - - - - - - - - - - -
SP18: - - - -
SP19: - - - - - - - - - -
SP20: - - - -
SP21:
SP22:
SP23: - -
SP24:
SP25:
SP26:

ExUns: 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b · 22c ^ 23a · 23b · 23c · 23d
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3:
SP4:
SP5: -
SP6: - - - - - - - - -
SP7:
SP8:
SP9:
SP10: - - - - - - -
SP11:
SP12: - - - - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22: - - -
SP23:
SP24: -
SP25:
SP26:

Relevant External Links for ENTPD6 Gene

GeneLoc Exon Structure for
ENTPD6
ECgene alternative splicing isoforms for
ENTPD6

Expression for ENTPD6 Gene

mRNA expression in normal human tissues for ENTPD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ENTPD6 Gene

This gene is overexpressed in Lung (27.2), Liver, secretome (25.9), and Fetal Brain (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ENTPD6 Gene



NURSA nuclear receptor signaling pathways regulating expression of ENTPD6 Gene:

ENTPD6

SOURCE GeneReport for Unigene cluster for ENTPD6 Gene:

Hs.500375

mRNA Expression by UniProt/SwissProt for ENTPD6 Gene:

O75354-ENTP6_HUMAN
Tissue specificity: Expressed in most tissues, but predominantly in heart.
genes like me logo Genes that share expression patterns with ENTPD6: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ENTPD6 Gene

Orthologs for ENTPD6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ENTPD6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ENTPD6 34
  • 82.97 (n)
  • 82.89 (a)
ENTPD6 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ENTPD6 34
  • 85.35 (n)
  • 86.59 (a)
ENTPD6 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Entpd6 34
  • 84.21 (n)
  • 87.89 (a)
Entpd6 16
Entpd6 35
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ENTPD6 34
  • 99.31 (n)
  • 99.17 (a)
ENTPD6 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Entpd6 34
  • 83.63 (n)
  • 87 (a)
oppossum
(Monodelphis domestica)
Mammalia ENTPD6 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ENTPD6 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves ENTPD6 35
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 50 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia entpd6 34
  • 58.22 (n)
  • 56.91 (a)
zebrafish
(Danio rerio)
Actinopterygii entpd6 34
  • 58.43 (n)
  • 54.92 (a)
entpd6 35
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NTPase 36
  • 39 (a)
NTPase 35
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K08H10.4 36
  • 34 (a)
uda-1 35
  • 26 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR362C 34
  • 45.47 (n)
  • 37.47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GDA1 35
  • 26 (a)
OneToMany
GDA1 37
rice
(Oryza sativa)
Liliopsida Os11g0125900 34
  • 46.42 (n)
  • 44.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToMany
Species where no ortholog for ENTPD6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENTPD6 Gene

ENSEMBL:
Gene Tree for ENTPD6 (if available)
TreeFam:
Gene Tree for ENTPD6 (if available)

Paralogs for ENTPD6 Gene

Paralogs for ENTPD6 Gene

genes like me logo Genes that share paralogs with ENTPD6: view

Variants for ENTPD6 Gene

Sequence variations from dbSNP and Humsavar for ENTPD6 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1044567 - 25,209,884(+) AAGCA(C/G)TGAAG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs2076559 - 25,206,577(+) AACGA(A/G)CTACA intron-variant, nc-transcript-variant, reference, missense
rs6050446 - 25,214,873(+) TGAAA(A/G)AAGTA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs6138541 - 25,221,256(+) GGTCA(A/G)CCCTT intron-variant, nc-transcript-variant, reference, missense
rs34007133 - 25,213,279(-) GTTCC(C/T)GGATT intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ENTPD6 Gene

Variant ID Type Subtype PubMed ID
dgv4290n100 CNV gain 25217958
dgv779e214 CNV gain 21293372
esv2020215 CNV deletion 18987734
esv3567929 CNV loss 25503493
esv3645578 CNV gain 21293372
nsv3340 CNV deletion 18451855
nsv522873 CNV gain 19592680
nsv585746 CNV gain 21841781

Variation tolerance for ENTPD6 Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.03; 80.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENTPD6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ENTPD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENTPD6 Gene

Disorders for ENTPD6 Gene

Relevant External Links for ENTPD6

Genetic Association Database (GAD)
ENTPD6
Human Genome Epidemiology (HuGE) Navigator
ENTPD6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ENTPD6

No disorders were found for ENTPD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENTPD6 Gene

Publications for ENTPD6 Gene

  1. CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart. (PMID: 11041856) Yeung G. … Ford J.E. (Biochemistry 2000) 3 4 22 65
  2. The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster. (PMID: 9676430) Chadwick B.P. … Frischauf A.-M. (Genomics 1998) 2 3 4 65
  3. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. (PMID: 22036096) Ramasamy A. … Jarvis D.L. (J. Allergy Clin. Immunol. 2011) 3 46 65
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for ENTPD6 Gene

Sources for ENTPD6 Gene

Content
Loading form....