Aliases for ENTPD6 Gene
External Ids for ENTPD6 Gene
Previous HGNC Symbols for ENTPD6 Gene
Previous GeneCards Identifiers for ENTPD6 Gene
ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
GeneCards Summary for ENTPD6 Gene
ENTPD6 (Ectonucleoside Triphosphate Diphosphohydrolase 6 (Putative)) is a Protein Coding gene. Among its related pathways are Purine metabolism (REACTOME) and Purine metabolism (KEGG). GO annotations related to this gene include hydrolase activity and nucleoside-diphosphatase activity. An important paralog of this gene is ENTPD5.
UniProtKB/Swiss-Prot for ENTPD6 Gene
Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5-diphosphates, nucleoside 5-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP (By similarity).