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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ENTPD5 Gene

protein-coding   GIFtS: 64
GCID: GC14M074424

Ectonucleoside Triphosphate Diphosphohydrolase 5

(Previous name: proto-oncogene CPH)
(Previous symbols: CD39L4, PCPH)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ectonucleoside Triphosphate Diphosphohydrolase 51 2     GDPase ENTPD52 3
CD39L41 2 3 5     NTPDase 52 3
PCPH1 2 3     UDPase ENTPD52 3
Proto-Oncogene CPH1 2     EC 3.6.1.63 8
Guanosine-Diphosphatase ENTPD52 3     NTPDase-52
Nucleoside Diphosphatase2 3     CD39-Like 42
Uridine-Diphosphatase ENTPD52 3     Pcph Proto-Oncogene Protein2
ER-UDPase2 3     EC 3.6.1.423
CD39 Antigen-Like 42 3     EC 3.6.18

External Ids:    HGNC: 33671   Entrez Gene: 9572   Ensembl: ENSG000001870977   OMIM: 6031625   UniProtKB: O753563   

Export aliases for ENTPD5 gene to outside databases

Previous GC identifers: GC14M071938 GC14M068228 GC14M072414 GC14M072423 GC14M073502 GC14M074433 GC14M054600


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ENTPD5 Gene:
The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such
as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is
characteristic of NTPases. (provided by RefSeq, Jan 2009)

GeneCards Summary for ENTPD5 Gene: 
ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5) is a protein-coding gene. Diseases associated with ENTPD5 include scrapie, and proliferative vitreoretinopathy, and among its related super-pathways are Pyrimidine metabolism. GO annotations related to this gene include guanosine-diphosphatase activity and uridine-diphosphatase activity. An important paralog of this gene is ENTPD6.

UniProtKB/Swiss-Prot: ENTP5_HUMAN, O75356
Function: Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP
hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP
consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP
hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. Also
hydrolyzes GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate.
Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to
phosphoinositide 3-kinase (PI3K) signaling (By similarity)

Gene Wiki entry for ENTPD5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ENTPD5 gene promoter:
         RFX1   AP-1   ATF-2   c-Jun   POU3F2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidENTPD5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ENTPD5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENTPD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24

ENTPD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ENTPD5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M074424:  view genomic region     (about GC identifiers)

Start:
74,424,713 bp from pter      End:
74,486,102 bp from pter
Size:
61,390 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ENTP5_HUMAN, O75356 (See protein sequence)
Recommended Name: Ectonucleoside triphosphate diphosphohydrolase 5  
Size: 428 amino acids; 47517 Da
Cofactor: Calcium (By similarity)
Cofactor: Magnesium (By similarity)
Subcellular location: Endoplasmic reticulum membrane (By similarity); Single-pass type II membrane protein (By
similarity)
Miscellaneous: May mediate some of the cancer-related phenotypes associated with AKT1 activation: its
up-regulation by AKT1 leads to the elevation of aerobic glycolysis seen in tumor cells, a phenomenon known as the
Warburg effect (PubMed:21074248)
Secondary accessions: A1L4C5 Q96RX0

Explore the universe of human proteins at neXtProt for ENTPD5: NX_O75356

Explore proteomics data for ENTPD5 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated; high-mannose type (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75356

  • 3 DME Specific Peptides for ENTPD5 (O75356)
     DLGGASTQ  GGASTQITF  FYAFSYYYD 

    ENTPD5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ENTPD5 Protein Expression
    REFSEQ proteins: NP_001240.1  
    ENSEMBL proteins: 
     ENSP00000451810   ENSP00000451499   ENSP00000335246   ENSP00000451591   ENSP00000451483  

    Human Recombinant Protein Products for ENTPD5: 
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    Novus Biologicals ENTPD5 Proteins
    Novus Biologicals ENTPD5 Lysate
    Sino Biological Recombinant Protein for ENTPD5
    Sino Biological Cell Lysate for ENTPD5 
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    Cloud-Clone Corp. Proteins for ENTPD5 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ISS--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    ENTPD5 for ontologies           About GeneDecksing



    ENTPD5 Antibody Products: 
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    Assay Products for ENTPD5: 
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    Cloud-Clone Corp. ELISAs for ENTPD5 
    Cloud-Clone Corp. CLIAs for ENTPD5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000407 GDA1_CD39_NTPase

    Graphical View of Domain Structure for InterPro Entry O75356

    ProtoNet protein and cluster: O75356

    UniProtKB/Swiss-Prot: ENTP5_HUMAN, O75356
    Similarity: Belongs to the GDA1/CD39 NTPase family


    ENTPD5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ENTP5_HUMAN, O75356
    Function: Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP
    hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP
    consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP
    hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. Also
    hydrolyzes GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate.
    Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to
    phosphoinositide 3-kinase (PI3K) signaling (By similarity)
    Catalytic activity: GDP + H(2)O = GMP + phosphate
    Catalytic activity: A nucleoside diphosphate + H(2)O = a nucleoside phosphate + phosphate
    Induction: Up-regulated in cell lines and primary tumor samples with active AKT1

         Enzyme Numbers (IUBMB): EC 3.6.1.61 2 EC 3.6.12 EC 3.6.1.421

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004382guanosine-diphosphatase activity ISS--
    GO:0016787hydrolase activity ----
    GO:0045134uridine-diphosphatase activity ISS--
         
    ENTPD5 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Entpd5):
     cardiovascular system  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  reproductive system  tumorigenesis 

    ENTPD5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Entpd5tm1Rre for ENTPD5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ENTPD5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ENTPD5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ENTPD5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ENTPD5 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ENTPD5
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate ENTPD5:
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    SwitchGear 3'UTR luciferase reporter plasmidENTPD5 3' UTR sequence
    Inhib. RNA
    Products:
        
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                         Customized lentivirus expression plasmids for stable overexpression of ENTPD5 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENTPD5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ENTPD5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Purine metabolism
    Purine metabolism0.38
    Pyrimidine metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2         Kegg Pathways  (Kegg details for ENTPD5):
        Purine metabolism
    Pyrimidine metabolism

    UniProtKB/Swiss-Prot: ENTP5_HUMAN, O75356
    Pathway: Protein modification; protein glycosylation


    ENTPD5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ENTPD5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/71 Interacting proteins for ENTPD5 (O753562, 3 ENSP000003352464) via UniProtKB, MINT, STRING, and/or I2D (see all 71)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCAP172523, ENSP000002843844I2D: score=1 STRING: ENSP00000284384
    ENTPD5O753562MINT-8216400
    APRTENSP000003676154STRING: ENSP00000367615
    ENTPD1ENSP000003602484STRING: ENSP00000360248
    ENTPD3ENSP000003018254STRING: ENSP00000301825
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006096glycolysis ISS--
    GO:0006487protein N-linked glycosylation ISS--
    GO:0008283cell proliferation ISS--
    GO:0014066regulation of phosphatidylinositol 3-kinase cascade ISS--
    GO:0016049cell growth ISS--

    ENTPD5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ENTPD5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ENTPD5 (ENTP5)

    10/14 HMDB Compounds for ENTPD5 (see all 14)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    CDPCDP (see all 3)63-38-7--
    CalciumCa (see all 2)7440-70-2--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    IDP5'-IDP (see all 10)86-04-4--
    Inosinic acid5'-IMP (see all 9)131-99-7--
    MagnesiumMagnesium (see all 2)7439-95-4--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Thiamine pyrophosphateTPP (see all 11)154-87-0--

    2 Novoseek inferred chemical compound relationships for ENTPD5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nucleoside 75.7 18 1851361 (2), 11042118 (2), 10369669 (2), 1304218 (1) (see all 14)
    magnesium 16.8 1 10400613 (1)

    Search CenterWatch for drugs/clinical trials and news about ENTPD5 / ENTP5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ENTPD5 gene: 
    NM_001249.2  

    Unigene Cluster for ENTPD5:

    Ectonucleoside triphosphate diphosphohydrolase 5
    Hs.720540  [show with all ESTs]
    Unigene Representative Sequence: NM_001249
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557325(uc001xpi.3) ENST00000555829 ENST00000334696(uc010tuo.2)
    ENST00000553284 ENST00000556242 ENST00000554664 ENST00000556108 ENST00000557681


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    hsa-miR-576-3p hsa-miR-9 hsa-miR-659 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-1827 hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidENTPD5 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENTPD5

    Additional mRNA sequence: 

    AF039918.1 AF136572.1 AY430094.1 BC107878.1 BC130485.1 BC130487.1 

    12 DOTS entries:

    DT.109444  DT.91652412  DT.70103907  DT.120749967  DT.92419972  DT.100682964  DT.97767993  DT.99934721 
    DT.91754474  DT.95151267  DT.40128897  DT.87017010 

    24/138 AceView cDNA sequences (see all 138):

    CB132877 AI832534 CB135509 CB851801 AV660733 BX109410 BC020966 AW675693 
    AI962548 AI432153 CB132043 BM785699 AI394646 AW117747 BM924818 BF431510 
    AI754441 AV660716 AI758388 CB163434 AI911588 AI473129 CB164104 BM969338 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD5 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                          -     -     -     -     -     -           -                                                                           
    SP2:                                                                    -                                                                           
    SP3:                          -     -     -     -     -     -                                                                                       
    SP4:                                                  -     -           -                                                                           
    SP5:              -           -     -                                                                                                               


    ECgene alternative splicing isoforms for ENTPD5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ENTPD5 expression in normal human tissues (normalized intensities)      ENTPD5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCTCAGCT
    ENTPD5 Expression
    About this image


    ENTPD5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Kidney (Urinary System)    fully expand to see all 6 entries
             Proximal Tubule Cells Proximal Tubule
             Proximal Tubule
             kidney ; cells in tubules   
             visceral organ/metanephros/renal cortex   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 5 entries
             colon ; peripheral nerve/ganglion   
             colonic mucosal (ibs)   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 4 entries
             urinary bladder ; urothelial cells   
             visceral organ/urogenital sinus/primitive bladder   
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             nasopharynx ; respiratory epithelial cells   
             sensory organ/nose/nasal cavity   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 3 entries
             small intestine ; glandular cells   
             small intestine   

    See ENTPD5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ENTPD5

    SOURCE GeneReport for Unigene cluster: Hs.720540

    UniProtKB/Swiss-Prot: ENTP5_HUMAN, O75356
    Tissue specificity: Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other
    tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ENTPD5 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Entpd51 , 5 ectonucleoside triphosphate diphosphohydrolase 51, 5 87.48(n)1
    88.5(a)1
      12 (39.18 cM)5
    124991  NM_007647.21  NP_031673.21 
     843738755 
    chicken
    (Gallus gallus)
    Aves ENTPD51 ectonucleoside triphosphate diphosphohydrolase 5 73.91(n)
    72.2(a)
      423343  XM_421258.2  XP_421258.2 
    lizard
    (Anolis carolinensis)
    Reptilia ENTPD56
    Uncharacterized protein
    72(a)
    1 ↔ 1
    1(23761929-23777774)
    zebrafish
    (Danio rerio)
    Actinopterygii entpd5b6
    ENTPD5 (1 of 2)6
    ectonucleoside triphosphate diphosphohydrolase 5
    51(a)
    50(a)
    1 ↔ many
    1 ↔ many
    20(54699213-54719744)
    17(45196774-45206530)
    fruit fly
    (Drosophila melanogaster)
    Insecta NTPase1 , 3 nucleoside diphosphatase3
    CD39-like NTPase1
    39(a)3
    49.63(n)1
    43.33(a)1
      2 23B73
    334951  NM_164513.31  NP_722860.11 
    worm
    (Caenorhabditis elegans)
    Secernentea K08H10.43
    uda-11
    GDA1/CD39 (nucleoside phosphatase)
    family3
    Protein UDA-11
    35(a)3
    46.47(n)1
    37.8(a)1
      V(10007557-10009848)3
    1793951  NM_073172.21  NP_505573.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GDA11 Gda1p 46.98(n)
    38.46(a)
      856669   NP_010872.1 


    ENSEMBL Gene Tree for ENTPD5 (if available)
    TreeFam Gene Tree for ENTPD5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ENTPD5 gene
    ENTPD62  
    1 SIMAP similar gene for ENTPD5 using alignment to 5 protein entries:     ENTP5_HUMAN (see all proteins):
    ENTPD6

    ENTPD5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ENTPD5
    PGOHUM00000261845 PGOHUM00000234294


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1252 SNPs in ENTPD5 are shown (see all 1252)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1911651161,2
    --74432945(+) AAAGGC/TAGGCT 1 -- int10--------
    rs757053341,2
    --74432985(+) TGTCCC/GCAGAG 1 -- int10--------
    rs1818214371,2
    --74433015(+) TAAGGC/TTGTAA 1 -- int10--------
    rs1440218951,2
    --74433042(+) AGTTAC/TTCTCT 1 -- int10--------
    rs1486749951,2
    --74433112(+) ATCATA/GCAGAT 1 -- int10--------
    rs1865085751,2
    --74433125(+) TGACAC/TGGTCC 1 -- int10--------
    rs71610371,2
    C,F--74433129(+) ATGGTC/ACCATT 1 -- int15Minor allele frequency- A:0.26NA EA 246
    rs116249461,2
    C,F,A,H--74433138(+) TTTTGT/CGTTGT 1 -- int122Minor allele frequency- C:0.38NS EA NA WA CSA 2338
    rs727237761,2
    C,F--74433141(+) TGCGTT/CGTTGA 1 -- int14Minor allele frequency- C:0.15NA WA EA 360
    rs1412811141,2
    C--74433171(+) CCAGG-/TGTTTT 1 -- spd10--------

    HapMap Linkage Disequilibrium report for ENTPD5 (74424713 - 74486102 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ENTPD5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2671078CNV Deletion23128226
    esv1198173CNV Deletion17803354
    nsv1352CNV Loss18451855
    nsv456339CNV Loss19166990
    nsv524396CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603162    OMIM disorders: --

    9 diseases for ENTPD5:    About MalaCards
    scrapie    proliferative vitreoretinopathy    germ cell tumors    crohn's disease
    laryngitis    multiple sclerosis    alzheimer's disease    prostate cancer
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ENTPD5:
    Scrapie

    ENTPD5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ENTPD5
    Human Genome Epidemiology (HuGE) Navigator: ENTPD5 (1 document)

    Export disorders for ENTPD5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ENTPD5 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with ENTPD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster. (PubMed id 9676430)1, 2, 3 Chadwick B.P. and Frischauf A.M. (1998)
    2. Analysis of SNPs with an effect on gene expression id entifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. (PubMed id 20601676)1, 4 Fransen K....Weersma R.K. (2010)
    3. The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. (PubMed id 21074248)1, 2 Fang M.... Wang X. (2010)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    5. The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells. (PubMed id 10708485)1, 2 Recio J.A....Notario V. (2000)
    6. Cloning and mapping of a human and mouse gene with homology to ecto- ATPase genes. (PubMed id 9271669)1, 3 Chadwick B.P. and Frischauf A.-M. (1997)
    7. PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism. (PubMed id 18006831)1, 9 Villar J....Notario V. (2007)
    8. PCPH/ENTPD5 expression confers to prostate cancer cells resistance against cisplatin-induced apoptosis through protein kinase Calpha-mediated Bcl-2 stabilization. (PubMed id 19117992)1, 9 Villar J....Notario V. (2009)
    9. CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates. (PubMed id 10400613)1, 9 Mulero J.J....Ford J.E. (1999)
    10. Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase. (PubMed id 15698960)1, 9 Murphy-Piedmonte D.M....Kirley T.L. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 957 HGNC: 3367 AceView: ENTPD5 Ensembl:ENSG00000187097 euGenes: HUgn957
    ECgene: ENTPD5 Kegg: 957 H-InvDB: ENTPD5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ENTPD5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ENTPD5 gene:
    Search GeneIP for patents involving ENTPD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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