ENTPD5 Gene

Aliases
for ENTPD5 gene

Previous GC identifers: GC14M071938 GC14M068228 GC14M072414 GC14M072423 GC14M073502 GC14M074433 GC14M054600

Summaries
for ENTPD5 gene

Genomic Views
for ENTPD5 gene

RefSeq DNA sequence:

NC_000014.8  NC_018925.1  NT_026437.12  

SwitchGear Promoter luciferase reporter plasmid: ENTPD5 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENTPD5

ENTPD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M074424:  view genomic region     (about GC identifiers)

Proteins
for ENTPD5 gene

Explore the universe of human proteins at neXtProt for ENTPD5: NX_O75356

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for ENTPD5 (CD39L4/ENTPD5)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: ENTPD5 OriGene Protein Over-expression Lysate: ENTPD5 OriGene Custom Protein Services for ENTPD5
	GenScript Custom Purified and Recombinant Proteins Services for ENTPD5
	Novus Biologicals ENTPD5 Proteins Novus Biologicals ENTPD5 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ENTPD5

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for ENTPD5 (CD39L4/ENTPD5)
	OriGene Antibodies (see all 3): ENTPD5 OriGene Custom Antibody Services for ENTPD5
	GenScript Custom Superior Antibodies Services for ENTPD5
	Novus Biologicals ENTPD5 Antibodies
	Abcam antibodies for ENTPD5
	Uscn Antibodies for ENTPD5
	ThermoFisher Antibodies for ENTPD5

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ENTPD5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ENTPD5

Protein Domains /
Families
for ENTPD5 gene

ProtoNet protein and cluster: O75356

Function
for ENTPD5 gene

     Enzyme Numbers (IUBMB): EC 3.6.1.6^{1 2} EC 3.6.1² EC 3.6.1.42¹

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Entpd5)

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ENTPD5

miRNA Products:		OriGene 3'-UTR Clone: ENTPD5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ENTPD5
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate ENTPD5:
		hsa-miR-576-3p hsa-miR-9 hsa-miR-659 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-1827 hsa-miR-23c
		SwitchGear 3'UTR luciferase reporter plasmid: ENTPD5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ENTPD5 (see all 7) OriGene shRNA RFP: ENTPD5 OriGene siRNA: ENTPD5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ENTPD5
		Sirion Biotech Custom design and validation of potent shRNA sequences against ENTPD5

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ENTPD5
			Sirion Biotech Customized adenovirus for overexpression of ENTPD5  Sirion Biotech Customized adenovirus for potent knockdown of ENTPD5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ENTPD5 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ENTPD5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ENTPD5 (NM_001249)
		Sino Biological Human cDNA Clone for ENTPD5
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENTPD5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENTPD5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ENTPD5
		Search LifeMap BioReagents cell lines for ENTPD5
		Sirion Biotech Customized stable knockdown cell line services for ENTPD5  Sirion Biotech Customized inducible knockdown cell line services for ENTPD5 Sirion Biotech Customized stable overexpressing cell line services for ENTPD5 Sirion Biotech Customized inducible overexpressing cell line services for ENTPD5

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENTPD5

Pathways & Interactions
for ENTPD5 gene

	Super-pathway	contained gene-specific pathways
1	Purine metabolism	Purine metabolism 1.00 Pyrimidine metabolism 0.38

2         Kegg Pathways  (Kegg details for ENTPD5)

	Purine metabolism
	Pyrimidine metabolism

ENTPD5 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ENTPD5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/71 Interacting proteins for ENTPD5 (O75356^{2, 3} ENSP00000335246⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 71)

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

Drugs & Compounds
for ENTPD5 gene

Transcripts
for ENTPD5 gene

Expression
for ENTPD5 gene

ENTPD5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCTCAGCT

About this image

ENTPD5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	KidneyProximal TubuleProximal Tubule Cells			Kidney
	KidneyEpithelial Tubule			Kidney
	KidneyMetanephros			Kidney
	KidneyProximal Tubule			Kidney
	Reproductive SystemMesonephros			Reproductive System
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ENTPD5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ENTPD5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ENTPD5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENTPD5

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENTPD5

Orthologs
for ENTPD5 gene

Paralogs
for ENTPD5 gene

Paralogs for ENTPD5 gene

ENTPD6²  

1 SIMAP similar gene for ENTPD5 using alignment to 5 protein entries:     ENTP5_HUMAN (see all proteins):

ENTPD6

ENTPD5 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for ENTPD5
PGOHUM00000261845 PGOHUM00000234294

Genomic Variants
for ENTPD5 gene

10/1117 NCBI SNPs in ENTPD5 are shown (see all 1117)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1911651161,2		--	74432945(+)	AAAGGC/TAGGCT	1	--	int1		0	--	--	--	--
rs757053341,2		--	74432985(+)	TGTCCC/GCAGAG	1	--	int1		0	--	--	--	--
rs1818214371,2		--	74433015(+)	TAAGGC/TTGTAA	1	--	int1		0	--	--	--	--
rs1440218951,2		--	74433042(+)	AGTTAC/TTCTCT	1	--	int1		0	--	--	--	--
rs1486749951,2		--	74433112(+)	ATCATA/GCAGAT	1	--	int1		0	--	--	--	--
rs1865085751,2		--	74433125(+)	TGACAC/TGGTCC	1	--	int1		0	--	--	--	--
rs71610371,2	C,F	--	74433129(+)	ATGGTC/ACCATT	1	--	int1		5		NA EA	246
rs116249461,2	C,F,A,H	--	74433138(+)	TTTTGT/CGTTGT	1	--	int1		22		NS EA NA WA CSA	2338
rs727237761,2	C	--	74433141(+)	TGCGTT/CGTTGA	1	--	int1		4		NA WA EA	360
rs358355141,2	C	--	74433172(+)	CCAGG-/TTTTTT	1	--	ut31		1		NA	2

HapMap Linkage Disequilibrium report for ENTPD5 (74424713 - 74486102 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ENTPD5
     1 Indel: 25431

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ENTPD5

DNA2.0 Custom Variant and Variant Library Synthesis for ENTPD5

Disorders / Diseases
for ENTPD5 gene

Publications
for ENTPD5 gene

PubMed articles for ENTPD5 gene, integrated from 9 sources (see all 41): (articles sorted by number of sources associating them with ENTPD5)

Utopia: connect your pdf to the dynamic world of online information

1. The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster. (PubMed id 9676430)^{1, 2, 3} Chadwick B.P. and Frischauf A.M. (1998)
2. The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. (PubMed id 21074248)^{1, 2} Fang M.... Wang X. (2010)
3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
4. The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells. (PubMed id 10708485)^{1, 2} Recio J.A....Notario V. (2000)
5. Cloning and mapping of a human and mouse gene with homology to ecto- ATPase genes. (PubMed id 9271669)^{1, 3} Chadwick B.P. and Frischauf A.-M. (1997)
6. PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism. (PubMed id 18006831)^{1, 9} Villar J....Notario V. (2007)
7. PCPH/ENTPD5 expression confers to prostate cancer cells resistance against cisplatin-induced apoptosis through protein kinase Calpha-mediated Bcl-2 stabilization. (PubMed id 19117992)^{1, 9} Villar J....Notario V. (2009)
8. CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates. (PubMed id 10400613)^{1, 9} Mulero J.J....Ford J.E. (1999)
9. Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase. (PubMed id 15698960)^{1, 9} Murphy-Piedmonte D.M....Kirley T.L. (2005)
10. ENTPD5-mediated modulation of ATP results in altered m etabolism and decreased survival in gliomablastoma multiforme. (PubMed id 22992974)¹ Zadran S....Zadran H. (2012)

External Searches for ENTPD5 gene

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Products
for ENTPD5 gene