Aliases for ENTPD5 Gene
External Ids for ENTPD5 Gene
Previous HGNC Symbols for ENTPD5 Gene
Previous GeneCards Identifiers for ENTPD5 Gene
The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]
GeneCards Summary for ENTPD5 Gene
ENTPD5 (Ectonucleoside Triphosphate Diphosphohydrolase 5) is a Protein Coding gene. Among its related pathways are Purine metabolism (KEGG) and Purine metabolism (KEGG). GO annotations related to this gene include uridine-diphosphatase activity and guanosine-diphosphatase activity. An important paralog of this gene is ENTPD6.
UniProtKB/Swiss-Prot for ENTPD5 Gene
Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.