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Aliases for ENTPD5 Gene

Aliases for ENTPD5 Gene

  • Ectonucleoside Triphosphate Diphosphohydrolase 5 2 3
  • CD39L4 3 4 6
  • Guanosine-Diphosphatase ENTPD5 3 4
  • Uridine-Diphosphatase ENTPD5 3 4
  • Nucleoside Diphosphatase 3 4
  • CD39 Antigen-Like 4 3 4
  • Proto-Oncogene CPH 2 3
  • GDPase ENTPD5 3 4
  • UDPase ENTPD5 3 4
  • EC 3.6.1.6 4 63
  • NTPDase 5 3 4
  • ER-UDPase 3 4
  • PCPH 3 4
  • Pcph Proto-Oncogene Protein 3
  • CD39-Like 4 3
  • EC 3.6.1.42 4
  • NTPDase-5 3
  • EC 3.6.1 63

External Ids for ENTPD5 Gene

Previous HGNC Symbols for ENTPD5 Gene

  • CD39L4
  • PCPH

Previous GeneCards Identifiers for ENTPD5 Gene

  • GC14M071938
  • GC14M068228
  • GC14M072414
  • GC14M072423
  • GC14M073502
  • GC14M074433
  • GC14M054600
  • GC14M074424

Summaries for ENTPD5 Gene

Entrez Gene Summary for ENTPD5 Gene

  • The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]

GeneCards Summary for ENTPD5 Gene

ENTPD5 (Ectonucleoside Triphosphate Diphosphohydrolase 5) is a Protein Coding gene. Among its related pathways are Purine metabolism (KEGG) and Purine metabolism (KEGG). GO annotations related to this gene include uridine-diphosphatase activity and guanosine-diphosphatase activity. An important paralog of this gene is ENTPD6.

UniProtKB/Swiss-Prot for ENTPD5 Gene

  • Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.

Gene Wiki entry for ENTPD5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENTPD5 Gene

Genomics for ENTPD5 Gene

Regulatory Elements for ENTPD5 Gene

Genomic Location for ENTPD5 Gene

Start:
73,958,010 bp from pter
End:
74,019,399 bp from pter
Size:
61,390 bases
Orientation:
Minus strand

Genomic View for ENTPD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ENTPD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENTPD5 Gene

Proteins for ENTPD5 Gene

  • Protein details for ENTPD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75356-ENTP5_HUMAN
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 5
    Protein Accession:
    O75356
    Secondary Accessions:
    • A1L4C5
    • Q96RX0

    Protein attributes for ENTPD5 Gene

    Size:
    428 amino acids
    Molecular mass:
    47517 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Exists both as a monomer and a disulfide-linked homodimer, the dimers are enzymatically inactive.
    Miscellaneous:
    • May mediate some of the cancer-related phenotypes associated with AKT1 activation: its up-regulation by AKT1 leads to the elevation of aerobic glycolysis seen in tumor cells, a phenomenon known as the Warburg effect.

neXtProt entry for ENTPD5 Gene

Proteomics data for ENTPD5 Gene at MOPED

Selected DME Specific Peptides for ENTPD5 Gene

Post-translational modifications for ENTPD5 Gene

  • N-glycosylated; high-mannose type (By similarity). Glycosylation is not essential for enzymatic activity.
  • Glycosylation at Asn232 and Asn368
  • Modification sites at PhosphoSitePlus

Other Protein References for ENTPD5 Gene

Domains for ENTPD5 Gene

Protein Domains for ENTPD5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ENTPD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75356

UniProtKB/Swiss-Prot:

ENTP5_HUMAN :
  • O75356
Family:
  • Belongs to the GDA1/CD39 NTPase family.
genes like me logo Genes that share domains with ENTPD5: view

No data available for Gene Families for ENTPD5 Gene

Function for ENTPD5 Gene

Molecular function for ENTPD5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: GDP + H(2)O = GMP + phosphate
UniProtKB/Swiss-Prot CatalyticActivity: A nucleoside diphosphate + H(2)O = a nucleoside phosphate + phosphate
UniProtKB/Swiss-Prot Function: Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.
UniProtKB/Swiss-Prot Induction: Up-regulated in cell lines and primary tumor samples with active AKT1.

Enzyme Numbers (IUBMB) for ENTPD5 Gene

Gene Ontology (GO) - Molecular Function for ENTPD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004382 guanosine-diphosphatase activity ISS --
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity --
GO:0045134 uridine-diphosphatase activity ISS --
genes like me logo Genes that share ontologies with ENTPD5: view
genes like me logo Genes that share phenotypes with ENTPD5: view

Animal Models for ENTPD5 Gene

MGI Knock Outs for ENTPD5:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ENTPD5 Gene

Localization for ENTPD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENTPD5 Gene

Endoplasmic reticulum. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ENTPD5 Gene COMPARTMENTS Subcellular localization image for ENTPD5 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
extracellular 2
plasma membrane 2
cytoskeleton 1
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ENTPD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ENTPD5: view

Pathways for ENTPD5 Gene

SuperPathways for ENTPD5 Gene

Superpath Contained pathways
1 Purine metabolism (KEGG)
genes like me logo Genes that share pathways with ENTPD5: view

Pathways by source for ENTPD5 Gene

2 KEGG pathways for ENTPD5 Gene

UniProtKB/Swiss-Prot O75356-ENTP5_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for ENTPD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006487 protein N-linked glycosylation ISS --
GO:0008152 metabolic process --
GO:0008283 cell proliferation ISS --
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling ISS --
GO:0016049 cell growth ISS --
genes like me logo Genes that share ontologies with ENTPD5: view

Compounds for ENTPD5 Gene

(14) HMDB Compounds for ENTPD5 Gene

Compound Synonyms Cas Number PubMed IDs
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
CDP
  • CDP
63-38-7
dTDP
  • Deoxy-tdp
491-97-4
Guanosine diphosphate
  • 5'-GDP
146-91-8

(2) Novoseek inferred chemical compound relationships for ENTPD5 Gene

Compound -log(P) Hits PubMed IDs
nucleoside 75.7 17
magnesium 16.8 1
genes like me logo Genes that share compounds with ENTPD5: view

Transcripts for ENTPD5 Gene

Unigene Clusters for ENTPD5 Gene

Ectonucleoside triphosphate diphosphohydrolase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - - - - - -
SP2: -
SP3: - - - - - -
SP4: - - -
SP5: - - -
SP6: -
SP7:
SP8:

Relevant External Links for ENTPD5 Gene

GeneLoc Exon Structure for
ENTPD5
ECgene alternative splicing isoforms for
ENTPD5

Expression for ENTPD5 Gene

mRNA expression in normal human tissues for ENTPD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENTPD5 Gene

This gene is overexpressed in Liver (6.3) and Colon - Transverse (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ENTPD5 Gene

SOURCE GeneReport for Unigene cluster for ENTPD5 Gene Hs.720540

mRNA Expression by UniProt/SwissProt for ENTPD5 Gene

O75356-ENTP5_HUMAN
Tissue specificity: Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues.
genes like me logo Genes that share expressions with ENTPD5: view

Orthologs for ENTPD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ENTPD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ENTPD5 35
  • 99.69 (n)
  • 99.53 (a)
ENTPD5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ENTPD5 35
  • 91.12 (n)
  • 92.29 (a)
ENTPD5 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ENTPD5 35
  • 93.54 (n)
  • 92.76 (a)
ENTPD5 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Entpd5 35
  • 87.48 (n)
  • 88.5 (a)
Entpd5 16
Entpd5 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ENTPD5 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Entpd5 35
  • 87.09 (n)
  • 86.15 (a)
chicken
(Gallus gallus)
Aves ENTPD5 35
  • 73.91 (n)
  • 72.2 (a)
ENTPD5 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ENTPD5 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia entpd5 35
  • 59.64 (n)
  • 55.45 (a)
zebrafish
(Danio rerio)
Actinopterygii entpd5a 36
  • 52 (a)
OneToMany
entpd5b 35
  • 61.26 (n)
  • 58.64 (a)
entpd5b 36
  • 52 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009265 35
  • 48.95 (n)
  • 42.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta NTPase 35
  • 49.63 (n)
  • 43.33 (a)
NTPase 36
  • 29 (a)
OneToMany
NTPase 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea uda-1 35
  • 46.76 (n)
  • 38.38 (a)
uda-1 36
  • 28 (a)
OneToMany
K08H10.4 37
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GDA1 35
  • 47.45 (n)
  • 39.55 (a)
GDA1 36
  • 25 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F16863g 35
  • 46.55 (n)
  • 39.39 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons APY2 35
  • 45.02 (n)
  • 34.79 (a)
rice
(Oryza sativa)
Liliopsida Os07g0682800 35
  • 47.81 (n)
  • 36.97 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03713 35
  • 45.41 (n)
  • 37.06 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gda1 35
  • 47.53 (n)
  • 39.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for ENTPD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENTPD5 Gene

ENSEMBL:
Gene Tree for ENTPD5 (if available)
TreeFam:
Gene Tree for ENTPD5 (if available)

Paralogs for ENTPD5 Gene

Paralogs for ENTPD5 Gene

Selected SIMAP similar genes for ENTPD5 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ENTPD5 Gene

genes like me logo Genes that share paralogs with ENTPD5: view

Variants for ENTPD5 Gene

Sequence variations from dbSNP and Humsavar for ENTPD5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs13743 -- 73,966,849(-) ACTAG(A/T)CTGGG utr-variant-3-prime, intron-variant
rs730505 -- 73,974,071(+) TCACC(A/T)TGGGG intron-variant
rs758240 -- 73,974,642(-) CTTTA(A/C)GAATA intron-variant
rs1029704 -- 73,963,744(-) GTGAC(A/G/T)AGACC intron-variant
rs1044591 -- 73,964,474(-) GGGAA(G/T)ATGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENTPD5 Gene

Variant ID Type Subtype PubMed ID
nsv1352 CNV Loss 18451855
nsv456339 CNV Loss 19166990
nsv524396 CNV Gain 19592680
esv1198173 CNV Deletion 17803354
esv2671078 CNV Deletion 23128226

Relevant External Links for ENTPD5 Gene

HapMap Linkage Disequilibrium report
ENTPD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENTPD5 Gene

Disorders for ENTPD5 Gene

(1) University of Copenhagen DISEASES for ENTPD5 Gene

Relevant External Links for ENTPD5

Genetic Association Database (GAD)
ENTPD5
Human Genome Epidemiology (HuGE) Navigator
ENTPD5
genes like me logo Genes that share disorders with ENTPD5: view

No data available for UniProtKB/Swiss-Prot for ENTPD5 Gene

Publications for ENTPD5 Gene

  1. CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates. (PMID: 10400613) Mulero J.J. … Ford J.E. (J. Biol. Chem. 1999) 3 4 23
  2. The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster. (PMID: 9676430) Chadwick B.P. … Frischauf A.-M. (Genomics 1998) 2 3 4
  3. Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase. (PMID: 15698960) Murphy-Piedmonte D.M. … Kirley T.L. (Biochim. Biophys. Acta 2005) 3 4 23
  4. PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism. (PMID: 18006831) Villar J. … Notario V. (Cancer Res. 2007) 3 23
  5. Cloning and mapping of a human and mouse gene with homology to ecto- ATPase genes. (PMID: 9271669) Chadwick B.P. … Frischauf A.-M. (Mamm. Genome 1997) 2 3

Products for ENTPD5 Gene

Sources for ENTPD5 Gene

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