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ENTPD5 Gene

protein-coding   GIFtS: 62
GCID: GC14M074424

Ectonucleoside Triphosphate Diphosphohydrolase 5

(Previous name: proto-oncogene CPH)
(Previous symbols: CD39L4, PCPH)
  Search for ENTPD5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ectonucleoside Triphosphate Diphosphohydrolase 51 2     GDPase ENTPD52 3
CD39L41 2 3 5     NTPDase 52 3
PCPH1 2 3     UDPase ENTPD52 3
Proto-Oncogene CPH1 2     EC 3.6.1.63 8
Guanosine-Diphosphatase ENTPD52 3     NTPDase-52
Nucleoside Diphosphatase2 3     CD39-Like 42
Uridine-Diphosphatase ENTPD52 3     Pcph Proto-Oncogene Protein2
ER-UDPase2 3     EC 3.6.1.423
CD39 Antigen-Like 42 3     EC 3.6.18

External Ids:    HGNC: 33671   Entrez Gene: 9572   Ensembl: ENSG000001870977   OMIM: 6031625   UniProtKB: O753563   
ORGUL members:         

Export aliases for ENTPD5 gene to outside databases

Previous GC identifers: GC14M071938 GC14M068228 GC14M072414 GC14M072423 GC14M073502 GC14M074433 GC14M054600


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ENTPD5 Gene:
The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such
as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is
characteristic of NTPases. (provided by RefSeq, Jan 2009)

GeneCards Summary for ENTPD5 Gene:
ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5) is a protein-coding gene. GO annotations related to this gene include guanosine-diphosphatase activity and uridine-diphosphatase activity. An important paralog of this gene is ENTPD6.

UniProtKB/Swiss-Prot: ENTP5_HUMAN, O75356
Function: Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP
hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP
consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP
hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The
nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates,
nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in
proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling

Gene Wiki entry for ENTPD5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ENTPD5 gene promoter:
         RFX1   AP-1   ATF-2   c-Jun   POU3F2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidENTPD5 promoter sequence
   Search Chromatin IP Primers for ENTPD5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ENTPD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24

ENTPD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ENTPD5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M074424:  view genomic region     (about GC identifiers)

Start:
74,424,713 bp from pter      End:
74,486,102 bp from pter
Size:
61,390 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ENTP5_HUMAN, O75356 (See protein sequence)
Recommended Name: Ectonucleoside triphosphate diphosphohydrolase 5 precursor  
Size: 428 amino acids; 47517 Da
Cofactor: Ca(2+) or Mg(2+)
Subunit: Exists both as a monomer and a disulfide-linked homodimer, the dimers are enzymatically inactive
Miscellaneous: May mediate some of the cancer-related phenotypes associated with AKT1 activation: its
up-regulation by AKT1 leads to the elevation of aerobic glycolysis seen in tumor cells, a phenomenon known as the
Warburg effect (PubMed:21074248)
Secondary accessions: A1L4C5 Q96RX0

Explore the universe of human proteins at neXtProt for ENTPD5: NX_O75356

Explore proteomics data for ENTPD5 at MOPED

Post-translational modifications: 

  • N-glycosylated; high-mannose type (By similarity). Glycosylation is not essential for enzymatic activity1
  • Glycosylation2 at Asn232, Asn368
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for ENTPD5 (O75356)
     DLGGASTQ  GGASTQITF  FYAFSYYYD 


    See ENTPD5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001240.1  
    ENSEMBL proteins: 
     ENSP00000451810   ENSP00000451499   ENSP00000335246   ENSP00000451591   ENSP00000451483  

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    Search eBioscience for ELISAs for ENTPD5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000407 GDA1_CD39_NTPase

    Graphical View of Domain Structure for InterPro Entry O75356

    ProtoNet protein and cluster: O75356

    UniProtKB/Swiss-Prot: ENTP5_HUMAN, O75356
    Similarity: Belongs to the GDA1/CD39 NTPase family


    Find genes that share domains with ENTPD5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ENTP5_HUMAN, O75356
    Function: Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP
    hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP
    consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP
    hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The
    nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates,
    nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in
    proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling
    Catalytic activity: GDP + H(2)O = GMP + phosphate
    Catalytic activity: A nucleoside diphosphate + H(2)O = a nucleoside phosphate + phosphate
    Induction: Up-regulated in cell lines and primary tumor samples with active AKT1

         Enzyme Numbers (IUBMB): EC 3.6.1.61 2 EC 3.6.12 EC 3.6.1.421

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004382guanosine-diphosphatase activity ISS--
    GO:0016787hydrolase activity ----
    GO:0045134uridine-diphosphatase activity ISS--
         
    Find genes that share ontologies with ENTPD5           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Entpd5):
     cardiovascular system  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  reproductive system  tumorigenesis 

    Find genes that share phenotypes with ENTPD5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Entpd5tm1Rre for ENTPD5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ENTPD5
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    miRNA
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    hsa-miR-576-3p hsa-miR-9 hsa-miR-659 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-1827 hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidENTPD5 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for ENTPD5
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENTPD5

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENTPD5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ENTP5_HUMAN, O75356: Endoplasmic reticulum (By similarity). Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    golgi apparatus3
    extracellular2
    plasma membrane2
    cytoskeleton1
    cytosol1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005783endoplasmic reticulum ISS--
    GO:0005789endoplasmic reticulum membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with ENTPD5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ENTPD5 About    
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (KEGG)
    Purine metabolism0.38
    Pyrimidine metabolism0.38


    Find genes that share SuperPaths with ENTPD5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for ENTPD5):
        Purine metabolism
    Pyrimidine metabolism

    UniProtKB/Swiss-Prot: ENTP5_HUMAN, O75356
    Pathway: Protein modification; protein glycosylation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ENTPD5
    Interactions:

        Search GeneGlobe Interaction Network for ENTPD5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ENTPD5 (O753562, 3 ENSP000003352464) via UniProtKB, MINT, STRING, and/or I2D (see all 81)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCAP172523, ENSP000002843844I2D: score=1 STRING: ENSP00000284384
    ENTPD5O753562MINT-8216400
    AK3ENSP000003712304STRING: ENSP00000371230
    AMPD1ENSP000003165204STRING: ENSP00000316520
    APRTENSP000003676154STRING: ENSP00000367615
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006096glycolytic process IEA--
    GO:0006487protein N-linked glycosylation ISS--
    GO:0008283cell proliferation ISS--
    GO:0014066regulation of phosphatidylinositol 3-kinase signaling ISS--
    GO:0016049cell growth ISS--

    Find genes that share ontologies with ENTPD5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ENTPD5 (ENTP5)

    Selected HMDB Compounds for ENTPD5 (see all 14)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    CDPCDP (see all 3)63-38-7--
    CalciumCa (see all 2)7440-70-2--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    IDP5'-IDP (see all 10)86-04-4--
    Inosinic acid5'-IMP (see all 9)131-99-7--
    MagnesiumMagnesium (see all 2)7439-95-4--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Thiamine pyrophosphateTPP (see all 11)154-87-0--

    2 Novoseek inferred chemical compound relationships for ENTPD5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nucleoside 75.7 18 1851361 (2), 11042118 (2), 10369669 (2), 1304218 (1) (see all 14)
    magnesium 16.8 1 10400613 (1)



    Find genes that share compounds with ENTPD5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ENTPD5 gene: 
    NM_001249.2  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557325(uc001xpi.3) ENST00000555829 ENST00000334696(uc010tuo.2)
    ENST00000553284 ENST00000556242 ENST00000554664 ENST00000556108 ENST00000557681

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    8 qRT-PCR Assays for microRNAs that regulate ENTPD5:
    hsa-miR-576-3p hsa-miR-9 hsa-miR-659 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-1827 hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidENTPD5 3' UTR sequence
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    Selected AceView cDNA sequences (see all 138):

    AV660733 AI394646 AV660716 CB163434 BF431510 AW675693 BM683721 AI962548 
    AI473129 BC020966 AI432153 BX109410 AI927632 AI672090 AI832534 BM785699 
    CB129529 CB135509 AI758388 CB851801 AI754441 AI017442 BM969338 CB132043 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD5 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                          -     -     -     -     -     -           -                                                                           
    SP2:                                                                    -                                                                           
    SP3:                          -     -     -     -     -     -                                                                                       
    SP4:                                                  -     -           -                                                                           
    SP5:              -           -     -                                                                                                               


    ECgene alternative splicing isoforms for ENTPD5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ENTPD5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCTCAGCT
    ENTPD5 Expression
    About this image


    ENTPD5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Proximal Tubule Cells Proximal Tubule
             Metanephros
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Epithelial Cells
             Proximal Tubule Cells Proximal Tubule
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
    ENTPD5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ENTPD5 Protein Expression

    UniProtKB/Swiss-Prot: ENTP5_HUMAN, O75356
    Tissue specificity: Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other
    tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENTPD5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ENTPD5 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Entpd51 , 5 ectonucleoside triphosphate diphosphohydrolase 51, 5 87.48(n)1
    88.5(a)1
      12 (39.18 cM)5
    124991  NM_007647.31  NP_031673.21 
     843738755 
    chicken
    (Gallus gallus)
    Aves ENTPD51 ectonucleoside triphosphate diphosphohydrolase 5 73.91(n)
    72.2(a)
      423343  XM_004941781.1  XP_004941838.1 
    lizard
    (Anolis carolinensis)
    Reptilia ENTPD56
    ectonucleoside triphosphate diphosphohydrolase 5
    72(a)
    1 ↔ 1
    1(23761929-23777774)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia entpd51 ectonucleoside triphosphate diphosphohydrolase 5 59.64(n)
    55.45(a)
      677734  NM_001199602.1  NP_001186531.1 
    zebrafish
    (Danio rerio)
    Actinopterygii entpd5b1 ectonucleoside triphosphate diphosphohydrolase 5b 61.26(n)
    58.64(a)
      100334492  XM_005170231.1  XP_005170288.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NTPase1 , 3 nucleoside diphosphatase3
    NTPase1
    39(a)3
    49.63(n)1
    43.33(a)1
      2 23B73
    334951  NM_001273043.11  NP_001259972.11 
    worm
    (Caenorhabditis elegans)
    Secernentea K08H10.43
    uda-11
    GDA1/CD39 (nucleoside phosphatase)
    family3
    uda-11
    35(a)3
    46.76(n)1
    38.38(a)1
      V(10007557-10009848)3
    1793951  NM_073172.31  NP_505573.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GDA11 GDA1 47.45(n)
    39.55(a)
      856669   NP_010872.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons APY21 APY2 45.02(n)
    34.79(a)
      831946  NM_121833.6  NP_197329.4 
    rice
    (Oryza sativa)
    Liliopsida Os07g06828001 Os07g0682800 47.81(n)
    36.97(a)
      4344315  NM_001067198.1  NP_001060663.1 


    ENSEMBL Gene Tree for ENTPD5 (if available)
    TreeFam Gene Tree for ENTPD5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ENTPD5 gene
    ENTPD62  
    1 SIMAP similar gene for ENTPD5 using alignment to 5 protein entries:     ENTP5_HUMAN (see all proteins):
    ENTPD6

    Find genes that share paralogs with ENTPD5           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ENTPD5
    PGOHUM00000261845 PGOHUM00000234294


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ENTPD5 (see all 1252)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1911651161,2
    --74432945(+) AAAGGC/TAGGCT 1 -- int10--------
    rs757053341,2
    --74432985(+) TGTCCC/GCAGAG 1 -- int10--------
    rs1818214371,2
    --74433015(+) TAAGGC/TTGTAA 1 -- int10--------
    rs1440218951,2
    --74433042(+) AGTTAC/TTCTCT 1 -- int10--------
    rs1486749951,2
    --74433112(+) ATCATA/GCAGAT 1 -- int10--------
    rs1865085751,2
    --74433125(+) TGACAC/TGGTCC 1 -- int10--------
    rs71610371,2
    C,F--74433129(+) ATGGTC/ACCATT 1 -- int15Minor allele frequency- A:0.26NA EA 246
    rs116249461,2
    C,F,A,H--74433138(+) TTTTGT/CGTTGT 1 -- int122Minor allele frequency- C:0.38NS EA NA WA CSA 2338
    rs727237761,2
    C,F--74433141(+) TGCGTT/CGTTGA 1 -- int14Minor allele frequency- C:0.15NA WA EA 360
    rs1412811141,2
    C--74433171(+) CCAGG-/TGTTTT 1 -- spd10--------

    HapMap Linkage Disequilibrium report for ENTPD5 (74424713 - 74486102 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ENTPD5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671078CNV Deletion23128226
    esv1198173CNV Deletion17803354
    nsv1352CNV Loss18451855
    nsv456339CNV Loss19166990
    nsv524396CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ENTPD5
    DNA2.0 Custom Variant and Variant Library Synthesis for ENTPD5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603162    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for ENTPD5:
    Scrapie

    Find genes that share disorders with ENTPD5           About GenesLikeMe

    Genetic Association Database (GAD): ENTPD5
    Human Genome Epidemiology (HuGE) Navigator: ENTPD5 (1 document)

    Export disorders for ENTPD5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ENTPD5 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with ENTPD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster. (PubMed id 9676430)1, 2, 3 Chadwick B.P. and Frischauf A.-M. (Genomics 1998)
    2. CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates. (PubMed id 10400613)1, 2, 9 Mulero J.J....Ford J.E. (J. Biol. Chem. 1999)
    3. Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase. (PubMed id 15698960)1, 2, 9 Murphy-Piedmonte D.M....Kirley T.L. (Biochim. Biophys. Acta 2005)
    4. Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. (PubMed id 20601676)1, 4 Fransen K....Weersma R.K. (Hum. Mol. Genet. 2010)
    5. The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. (PubMed id 21074248)1, 2 Fang M.... Wang X. (Cell 2010)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    7. The human PCPH proto-oncogene: cDNA identification, primary structure, chromosomal mapping, and expression in normal and tumor cells. (PubMed id 10708485)1, 2 Recio J.A....Notario V. (Mol. Carcinog. 2000)
    8. Biochemical characterization of CD39L4. (PubMed id 11041857)1, 2 Mulero J.J....Ford J.E. (Biochemistry 2000)
    9. Cloning and mapping of a human and mouse gene with homology to ecto- ATPase genes. (PubMed id 9271669)1, 3 Chadwick B.P. and Frischauf A.-M. (Mamm. Genome 1997)
    10. PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism. (PubMed id 18006831)1, 9 Villar J....Notario V. (Cancer Res. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 957 HGNC: 3367 AceView: ENTPD5 Ensembl:ENSG00000187097 euGenes: HUgn957
    ECgene: ENTPD5 Kegg: 957 H-InvDB: ENTPD5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ENTPD5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ENTPD5 gene:
    Search GeneIP for patents involving ENTPD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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