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Aliases for ENTPD4 Gene

Aliases for ENTPD4 Gene

  • Ectonucleoside Triphosphate Diphosphohydrolase 4 2 3 5
  • Lysosomal Apyrase-Like Protein Of 70 KDa 3 4
  • Lysosomal Apyrase-Like 1 2 3
  • Uridine-Diphosphatase 3 4
  • EC 4 58
  • LYSAL1 3 4
  • LALP70 3 4
  • UDPase 3 4
  • Guanosine-Diphosphatase Like Protein 3
  • Golgi Luminal UDPase 3
  • NTPDase-4 3
  • NTPDase 4 4
  • KIAA0392 4
  • LAP70 3

External Ids for ENTPD4 Gene

Previous HGNC Symbols for ENTPD4 Gene

  • LYSAL1

Previous GeneCards Identifiers for ENTPD4 Gene

  • GC00U990801
  • GC08M021834
  • GC08M023243

Summaries for ENTPD4 Gene

Entrez Gene Summary for ENTPD4 Gene

  • This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011]

GeneCards Summary for ENTPD4 Gene

ENTPD4 (Ectonucleoside Triphosphate Diphosphohydrolase 4) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism. GO annotations related to this gene include hydrolase activity and uridine-diphosphatase activity. An important paralog of this gene is ENTPD7.

UniProtKB/Swiss-Prot for ENTPD4 Gene

  • Hydrolyzes preferentially nucleoside 5-diphosphates, nucleoside 5-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP.

Additional gene information for ENTPD4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENTPD4 Gene

Genomics for ENTPD4 Gene

Regulatory Elements for ENTPD4 Gene

Enhancers for ENTPD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H023159 1.7 FANTOM5 ENCODE dbSUPER 31.4 +295.3 295343 5.1 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ENSG00000253200 ENTPD4 C8orf58 POLR3D CCAR2 BIN3 CHMP7 TNFRSF10A LOC389641 ENSG00000250714
GH08H023538 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.4 -83.2 -83188 5.5 SIN3A FEZF1 ZNF766 ZNF143 FOS DEK SREBF1 NFIL3 ATF4 SMARCA4 ENTPD4 ENSG00000253390 SLC25A37 STC1 TNFRSF10B TNFRSF10C GC08M023551
GH08H023409 1.4 Ensembl ENCODE dbSUPER 21 +46.9 46887 3.4 HDAC1 PKNOX1 RB1 ZSCAN4 ARID4B SIN3A ZNF2 RAD21 RARA EGR1 ENTPD4 ENSG00000253390 R3HCC1 CHMP7 LOXL2 SLC25A37 RHOBTB2 PIR45078
GH08H023496 1.3 ENCODE dbSUPER 21.5 -36.6 -36632 0.2 PKNOX1 ARNT YBX1 ZNF766 ZC3H11A REST SMARCB1 ZNF592 MEF2D SMARCA4 ENTPD4 ENSG00000253200 C8orf58 CCAR2 SLC25A37 ENSG00000253390 NKX3-1 BIN3 CHMP7 LOC105379327
GH08H023557 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.8 -102.4 -102362 4.8 ELF3 FOXA2 ZSCAN9 RAD21 RARA YY1 RCOR1 FOS ETV6 IKZF2 SLC25A37 ENTPD4 ENSG00000253390 NKX3-1 RNU4-71P ENSG00000253200 EGR3 TNFRSF10C TNFRSF10B GC08M023551
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ENTPD4 on UCSC Golden Path with GeneCards custom track

Promoters for ENTPD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000222227 131 1601 PKNOX1 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF766 GLIS2 ZNF143

Genomic Locations for ENTPD4 Gene

Genomic Locations for ENTPD4 Gene
71,949 bases
Minus strand

Genomic View for ENTPD4 Gene

Genes around ENTPD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENTPD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENTPD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENTPD4 Gene

Proteins for ENTPD4 Gene

  • Protein details for ENTPD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 4
    Protein Accession:
    Secondary Accessions:
    • D3DSS3
    • O15092

    Protein attributes for ENTPD4 Gene

    616 amino acids
    Molecular mass:
    70255 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ENTPD4 Gene


neXtProt entry for ENTPD4 Gene

Selected DME Specific Peptides for ENTPD4 Gene


Post-translational modifications for ENTPD4 Gene

  • Glycosylation at isoforms=2404 and posLast=407407
  • Modification sites at PhosphoSitePlus

Other Protein References for ENTPD4 Gene

Domains & Families for ENTPD4 Gene

Gene Families for ENTPD4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ENTPD4 Gene

Suggested Antigen Peptide Sequences for ENTPD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GDA1/CD39 NTPase family.
  • Belongs to the GDA1/CD39 NTPase family.
genes like me logo Genes that share domains with ENTPD4: view

Function for ENTPD4 Gene

Molecular function for ENTPD4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A nucleoside diphosphate + H(2)O = a nucleoside phosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes preferentially nucleoside 5-diphosphates, nucleoside 5-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP.

Enzyme Numbers (IUBMB) for ENTPD4 Gene

Phenotypes From GWAS Catalog for ENTPD4 Gene

Gene Ontology (GO) - Molecular Function for ENTPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0017110 nucleoside-diphosphatase activity EXP 9556635
GO:0017111 nucleoside-triphosphatase activity EXP 9556635
GO:0045134 uridine-diphosphatase activity IEA,IDA 9556635
genes like me logo Genes that share ontologies with ENTPD4: view
genes like me logo Genes that share phenotypes with ENTPD4: view

miRNA for ENTPD4 Gene

miRTarBase miRNAs that target ENTPD4

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENTPD4 Gene

Localization for ENTPD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENTPD4 Gene

Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Note=Localizes in the Golgi and autophagic vacuoles/lysosomes.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENTPD4 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ENTPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0000421 autophagosome membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ENTPD4: view

Pathways & Interactions for ENTPD4 Gene

genes like me logo Genes that share pathways with ENTPD4: view

Pathways by source for ENTPD4 Gene

Gene Ontology (GO) - Biological Process for ENTPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006256 UDP catabolic process IDA 9556635
GO:0034656 nucleobase-containing small molecule catabolic process TAS --
genes like me logo Genes that share ontologies with ENTPD4: view

No data available for SIGNOR curated interactions for ENTPD4 Gene

Drugs & Compounds for ENTPD4 Gene

(12) Drugs for ENTPD4 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
CDP Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0

(4) Additional Compounds for ENTPD4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
  • 5'-IDP
  • IDP
  • Inosine 5'-(trihydrogen diphosphate)
  • Inosine 5'-(trihydrogen pyrophosphate)
  • Inosine 5'-diphosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with ENTPD4: view

Transcripts for ENTPD4 Gene

Unigene Clusters for ENTPD4 Gene

Ectonucleoside triphosphate diphosphohydrolase 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^
SP1: - - - - - - - -
SP2: - - - - -
SP3: -
SP4: -
SP5: -
SP7: -

ExUns: 17 ^ 18
SP1: -

Relevant External Links for ENTPD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ENTPD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ENTPD4 Gene

Protein differential expression in normal tissues from HIPED for ENTPD4 Gene

This gene is overexpressed in Cervix (61.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ENTPD4 Gene

Protein tissue co-expression partners for ENTPD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ENTPD4 Gene:


SOURCE GeneReport for Unigene cluster for ENTPD4 Gene:


mRNA Expression by UniProt/SwissProt for ENTPD4 Gene:

Tissue specificity: Ubiquitous. Highest expression in testis and lowest in bladder.

Evidence on tissue expression from TISSUES for ENTPD4 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ENTPD4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENTPD4 Gene

Orthologs for ENTPD4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENTPD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ENTPD4 34 33
  • 99.57 (n)
(Bos Taurus)
Mammalia ENTPD4 34
  • 94 (a)
(Mus musculus)
Mammalia Entpd4 34
  • 93 (a)
Gm21685 33
  • 86.13 (n)
Entpd4b 16
(Canis familiaris)
Mammalia ENTPD4 34 33
  • 90.53 (n)
(Monodelphis domestica)
Mammalia ENTPD4 34
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia ENTPD4 34
  • 89 (a)
(Rattus norvegicus)
Mammalia Entpd4 33
  • 85.28 (n)
(Gallus gallus)
Aves ENTPD4 33 34
  • 78.35 (n)
(Anolis carolinensis)
Reptilia ENTPD4 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia entpd4 33
  • 70.92 (n)
Str.13999 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33899 33
(Danio rerio)
Actinopterygii entpd4 33 34
  • 68.53 (n)
wufd44h12 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7450 33
(Caenorhabditis elegans)
Secernentea ntp-1 34
  • 33 (a)
mig-23 34
  • 32 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR006W 33
  • 45.89 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YND1 34
  • 25 (a)
Species where no ortholog for ENTPD4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENTPD4 Gene

Gene Tree for ENTPD4 (if available)
Gene Tree for ENTPD4 (if available)

Paralogs for ENTPD4 Gene

Paralogs for ENTPD4 Gene

(1) SIMAP similar genes for ENTPD4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ENTPD4: view

Variants for ENTPD4 Gene

Sequence variations from dbSNP and Humsavar for ENTPD4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000114003 -- 23,457,462(+) CGGCC(C/G)GCTCG intron-variant
rs1000184773 -- 23,455,961(+) GATGA(C/G)CACAG intron-variant
rs1000206855 -- 23,438,048(+) AGATG(C/T)CCTGT intron-variant
rs1000214253 -- 23,443,209(+) TGATA(C/T)TTTTT intron-variant
rs1000235128 -- 23,457,612(+) ATCAC(A/G)GCCAG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ENTPD4 Gene

Variant ID Type Subtype PubMed ID
nsv831268 CNV gain 17160897
nsv610779 CNV gain 21841781
nsv508499 CNV deletion 20534489
nsv470206 CNV gain 18288195
nsv1119172 CNV deletion 24896259
nsv1026345 CNV gain 25217958
nsv1017570 CNV gain 25217958
dgv7140n100 CNV gain 25217958
dgv7139n100 CNV loss 25217958

Variation tolerance for ENTPD4 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENTPD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENTPD4 Gene

Disorders for ENTPD4 Gene

Relevant External Links for ENTPD4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ENTPD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENTPD4 Gene

Publications for ENTPD4 Gene

  1. A human intracellular apyrase-like protein, LALP70, localizes to lysosomal/autophagic vacuoles. (PMID: 10393803) Biederbick A … Elsässer HP (Journal of cell science 1999) 2 3 4 22 60
  2. Golgi localization and functional expression of human uridine diphosphatase. (PMID: 9556635) Wang TF … Guidotti G (The Journal of biological chemistry 1998) 3 4 22 60
  3. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 60
  4. An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia. (PMID: 20537721) Saito A … Akiyama K (Psychiatry research 2011) 3 45 60
  5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 45 60

Products for ENTPD4 Gene

Sources for ENTPD4 Gene

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