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Aliases for ENTPD4 Gene

Aliases for ENTPD4 Gene

  • Ectonucleoside Triphosphate Diphosphohydrolase 4 2 3 5
  • Lysosomal Apyrase-Like Protein Of 70 KDa 3 4
  • Lysosomal Apyrase-Like 1 2 3
  • Uridine-Diphosphatase 3 4
  • EC 4 63
  • LYSAL1 3 4
  • LALP70 3 4
  • UDPase 3 4
  • Guanosine-Diphosphatase Like Protein 3
  • Golgi Luminal UDPase 3
  • NTPDase-4 3
  • NTPDase 4 4
  • KIAA0392 4
  • LAP70 3

External Ids for ENTPD4 Gene

Previous HGNC Symbols for ENTPD4 Gene

  • LYSAL1

Previous GeneCards Identifiers for ENTPD4 Gene

  • GC00U990801
  • GC08M021834
  • GC08M023243

Summaries for ENTPD4 Gene

Entrez Gene Summary for ENTPD4 Gene

  • This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011]

GeneCards Summary for ENTPD4 Gene

ENTPD4 (Ectonucleoside Triphosphate Diphosphohydrolase 4) is a Protein Coding gene. Among its related pathways are Lysosome and Pyrimidine metabolism (KEGG). GO annotations related to this gene include hydrolase activity and uridine-diphosphatase activity. An important paralog of this gene is ENTPD3.

UniProtKB/Swiss-Prot for ENTPD4 Gene

  • Hydrolyzes preferentially nucleoside 5-diphosphates, nucleoside 5-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENTPD4 Gene

Genomics for ENTPD4 Gene

Regulatory Elements for ENTPD4 Gene

Enhancers for ENTPD4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ENTPD4 on UCSC Golden Path with GeneCards custom track

Promoters for ENTPD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ENTPD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ENTPD4 Gene

23,385,783 bp from pter
23,457,731 bp from pter
71,949 bases
Minus strand

Genomic View for ENTPD4 Gene

Genes around ENTPD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENTPD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENTPD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENTPD4 Gene

Proteins for ENTPD4 Gene

  • Protein details for ENTPD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 4
    Protein Accession:
    Secondary Accessions:
    • D3DSS3
    • O15092

    Protein attributes for ENTPD4 Gene

    616 amino acids
    Molecular mass:
    70255 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ENTPD4 Gene


neXtProt entry for ENTPD4 Gene

Proteomics data for ENTPD4 Gene at MOPED

Selected DME Specific Peptides for ENTPD4 Gene

Post-translational modifications for ENTPD4 Gene

  • Glycosylation at Asn 404 and Asn 407
  • Modification sites at PhosphoSitePlus

Other Protein References for ENTPD4 Gene

Domains & Families for ENTPD4 Gene

Protein Domains for ENTPD4 Gene

Suggested Antigen Peptide Sequences for ENTPD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GDA1/CD39 NTPase family.
  • Belongs to the GDA1/CD39 NTPase family.
genes like me logo Genes that share domains with ENTPD4: view

No data available for Gene Families for ENTPD4 Gene

Function for ENTPD4 Gene

Molecular function for ENTPD4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A nucleoside diphosphate + H(2)O = a nucleoside phosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes preferentially nucleoside 5-diphosphates, nucleoside 5-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP.

Enzyme Numbers (IUBMB) for ENTPD4 Gene

Phenotypes for ENTPD4 Gene

genes like me logo Genes that share phenotypes with ENTPD4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ENTPD4

miRNA for ENTPD4 Gene

miRTarBase miRNAs that target ENTPD4

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENTPD4 Gene

Localization for ENTPD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENTPD4 Gene

Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Note=Localizes in the Golgi and autophagic vacuoles/lysosomes.

Subcellular locations from

Jensen Localization Image for ENTPD4 Gene COMPARTMENTS Subcellular localization image for ENTPD4 gene
Compartment Confidence
golgi apparatus 5
vacuole 4
plasma membrane 3
endoplasmic reticulum 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ENTPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with ENTPD4: view

Pathways & Interactions for ENTPD4 Gene

genes like me logo Genes that share pathways with ENTPD4: view

Pathways by source for ENTPD4 Gene

3 KEGG pathways for ENTPD4 Gene

Interacting Proteins for ENTPD4 Gene

Gene Ontology (GO) - Biological Process for ENTPD4 Gene


No data available for SIGNOR curated interactions for ENTPD4 Gene

Drugs & Compounds for ENTPD4 Gene

(10) Drugs for ENTPD4 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CDP Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Inosinic acid Experimental Pharma 0

(6) Additional Compounds for ENTPD4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
  • 5'-IDP
  • IDP
  • Inosine 5'-(trihydrogen diphosphate)
  • Inosine 5'-(trihydrogen pyrophosphate)
  • Inosine 5'-diphosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
genes like me logo Genes that share compounds with ENTPD4: view

Transcripts for ENTPD4 Gene

Unigene Clusters for ENTPD4 Gene

Ectonucleoside triphosphate diphosphohydrolase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^
SP1: - - - - - - - -
SP2: - - - - -
SP3: -
SP4: -
SP5: -
SP7: -

ExUns: 17 ^ 18
SP1: -

Relevant External Links for ENTPD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ENTPD4 Gene

mRNA expression in normal human tissues for ENTPD4 Gene

Protein differential expression in normal tissues from HIPED for ENTPD4 Gene

This gene is overexpressed in Cervix (61.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ENTPD4 Gene

SOURCE GeneReport for Unigene cluster for ENTPD4 Gene Hs.444389

mRNA Expression by UniProt/SwissProt for ENTPD4 Gene

Tissue specificity: Ubiquitous. Highest expression in testis and lowest in bladder.
genes like me logo Genes that share expression patterns with ENTPD4: view

Protein tissue co-expression partners for ENTPD4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ENTPD4 Gene

Orthologs for ENTPD4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENTPD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ENTPD4 35
  • 90.53 (n)
  • 94.81 (a)
  • 95 (a)
(Mus musculus)
Mammalia Gm21685 35
  • 86.13 (n)
  • 93.47 (a)
Gm21685 16
Entpd4 36
  • 93 (a)
(Pan troglodytes)
Mammalia ENTPD4 35
  • 99.57 (n)
  • 99.84 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Entpd4 35
  • 85.28 (n)
  • 93.06 (a)
(Bos Taurus)
Mammalia ENTPD4 36
  • 94 (a)
(Monodelphis domestica)
Mammalia ENTPD4 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia ENTPD4 36
  • 89 (a)
(Gallus gallus)
Aves ENTPD4 35
  • 78.35 (n)
  • 86.2 (a)
  • 86 (a)
(Anolis carolinensis)
Reptilia ENTPD4 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia entpd4 35
  • 70.92 (n)
  • 77.78 (a)
Str.13999 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33899 35
(Danio rerio)
Actinopterygii entpd4 35
  • 68.53 (n)
  • 71.55 (a)
wufd44h12 35
entpd4 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7450 35
(Caenorhabditis elegans)
Secernentea mig-23 36
  • 32 (a)
ntp-1 36
  • 33 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR006W 35
  • 45.89 (n)
  • 35.99 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YND1 36
  • 25 (a)
Species with no ortholog for ENTPD4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENTPD4 Gene

Gene Tree for ENTPD4 (if available)
Gene Tree for ENTPD4 (if available)

Paralogs for ENTPD4 Gene

Paralogs for ENTPD4 Gene

(1) SIMAP similar genes for ENTPD4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ENTPD4: view

Variants for ENTPD4 Gene

Sequence variations from dbSNP and Humsavar for ENTPD4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2272641 - 23,437,248(-) TGGGT(A/G)AACAG reference, missense
VAR_064711 -
rs2272640 -- 23,444,651(-) TGTTA(C/T)AGCTA intron-variant
rs2272642 -- 23,436,899(-) ATGCT(C/T)TTGAG intron-variant
rs2272643 -- 23,436,879(-) TGGAC(A/G)GTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENTPD4 Gene

Variant ID Type Subtype PubMed ID
nsv831268 CNV Gain 17160897
nsv470206 CNV Gain 18288195
nsv508499 CNV Loss 20534489

Variation tolerance for ENTPD4 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ENTPD4 Gene

Disorders for ENTPD4 Gene

Relevant External Links for ENTPD4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ENTPD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENTPD4 Gene

Publications for ENTPD4 Gene

  1. A human intracellular apyrase-like protein, LALP70, localizes to lysosomal/autophagic vacuoles. (PMID: 10393803) Biederbick A. … Elsaesser H.-P. (J. Cell Sci. 1999) 2 3 4 23 67
  2. The VSFASSQQ motif confers calcium sensitivity to the intracellular apyrase LALP70. (PMID: 15200686) Biederbick A. … ElsAosser H.P. (BMC Biochem. 2004) 3 23
  3. Golgi localization and functional expression of human uridine diphosphatase. (PMID: 9556635) Wang T.-F. … Guidotti G. (J. Biol. Chem. 1998) 3 23
  4. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ENTPD4 Gene

Sources for ENTPD4 Gene