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Aliases for ENTPD3 Gene

Aliases for ENTPD3 Gene

  • Ectonucleoside Triphosphate Diphosphohydrolase 3 2 3
  • Ecto-ATP Diphosphohydrolase 3 3 4
  • CD39 Antigen-Like 3 3 4
  • Ecto-ATPDase 3 3 4
  • Ecto-Apyrase 3 3 4
  • Ecto-ATPase 3 3 4
  • EC 4 63
  • NTPDase 3 3 4
  • CD39L3 3 4
  • HB6 3 4
  • NTPDase-3 3
  • EC 3.6.1 63

External Ids for ENTPD3 Gene

Previous HGNC Symbols for ENTPD3 Gene

  • CD39L3

Previous GeneCards Identifiers for ENTPD3 Gene

  • GC03P039737
  • GC03P039656
  • GC03P040241
  • GC03P040389

Summaries for ENTPD3 Gene

Entrez Gene Summary for ENTPD3 Gene

  • This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014]

GeneCards Summary for ENTPD3 Gene

ENTPD3 (Ectonucleoside Triphosphate Diphosphohydrolase 3) is a Protein Coding gene. Among its related pathways are Epstein-Barr virus infection and Pyrimidine metabolism (KEGG). GO annotations related to this gene include hydrolase activity and nucleoside-diphosphatase activity. An important paralog of this gene is ENTPD4.

UniProtKB/Swiss-Prot for ENTPD3 Gene

  • Has a threefold preference for the hydrolysis of ATP over ADP

Tocris Summary for ENTPD3 Gene

  • Ectonucleotidases (also known as NTPDases, Ecto-ATPases, ectonucleoside triphosphate diphosphohydrolase) are constitutively expressed ectoenzymes that hydrolyze extracellular nucleotides. There are four known major families of ectonucleotidases.

Gene Wiki entry for ENTPD3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENTPD3 Gene

Genomics for ENTPD3 Gene

Regulatory Elements for ENTPD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ENTPD3 Gene

40,387,156 bp from pter
40,428,626 bp from pter
41,471 bases
Plus strand

Genomic View for ENTPD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ENTPD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENTPD3 Gene

Proteins for ENTPD3 Gene

  • Protein details for ENTPD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 3
    Protein Accession:
    Secondary Accessions:
    • B2R8D0
    • G5E9N0
    • O60495
    • Q8N6K2

    Protein attributes for ENTPD3 Gene

    529 amino acids
    Molecular mass:
    59105 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ENTPD3 Gene


neXtProt entry for ENTPD3 Gene

Proteomics data for ENTPD3 Gene at MOPED

Selected DME Specific Peptides for ENTPD3 Gene

Post-translational modifications for ENTPD3 Gene

  • Glycosylation at Asn 81, Asn 149, Asn 238, Asn 381, Asn 392, Asn 402, and Asn 454
  • Modification sites at PhosphoSitePlus

Other Protein References for ENTPD3 Gene

Antibody Products

  • R&D Systems Antibodies for ENTPD3 (CD39L3/ENTPD3)

Domains & Families for ENTPD3 Gene

Protein Domains for ENTPD3 Gene

Suggested Antigen Peptide Sequences for ENTPD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GDA1/CD39 NTPase family.
  • Belongs to the GDA1/CD39 NTPase family.
genes like me logo Genes that share domains with ENTPD3: view

No data available for Gene Families for ENTPD3 Gene

Function for ENTPD3 Gene

Molecular function for ENTPD3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A nucleoside 5-triphosphate + 2 H(2)O = a nucleoside 5-phosphate + 2 phosphate
UniProtKB/Swiss-Prot Function:
Has a threefold preference for the hydrolysis of ATP over ADP

Enzyme Numbers (IUBMB) for ENTPD3 Gene

Gene Ontology (GO) - Molecular Function for ENTPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity --
GO:0017110 nucleoside-diphosphatase activity IEA --
GO:0017111 nucleoside-triphosphatase activity IEA --
genes like me logo Genes that share ontologies with ENTPD3: view

Phenotypes for ENTPD3 Gene

GenomeRNAi human phenotypes for ENTPD3:
genes like me logo Genes that share phenotypes with ENTPD3: view

Animal Model Products

miRNA for ENTPD3 Gene

miRTarBase miRNAs that target ENTPD3

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ENTPD3 Gene

Localization for ENTPD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENTPD3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ENTPD3 Gene COMPARTMENTS Subcellular localization image for ENTPD3 gene
Compartment Confidence
extracellular 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ENTPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ENTPD3: view

Pathways & Interactions for ENTPD3 Gene

genes like me logo Genes that share pathways with ENTPD3: view

Pathways by source for ENTPD3 Gene

1 GeneGo (Thomson Reuters) pathway for ENTPD3 Gene

Gene Ontology (GO) - Biological Process for ENTPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0009134 nucleoside diphosphate catabolic process IEA --
GO:0009143 nucleoside triphosphate catabolic process IEA --
genes like me logo Genes that share ontologies with ENTPD3: view

No data available for SIGNOR curated interactions for ENTPD3 Gene

Drugs & Compounds for ENTPD3 Gene

(15) Drugs for ENTPD3 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
5-Thymidylic acid Experimental Pharma 0
CDP Experimental Pharma 0
Cytidine triphosphate Experimental Pharma 0

(15) Additional Compounds for ENTPD3 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
  • 5'-IDP
  • IDP
  • Inosine 5'-(trihydrogen diphosphate)
  • Inosine 5'-(trihydrogen pyrophosphate)
  • Inosine 5'-diphosphate
inosine triphosphate
  • 2'-Inosine-5'-triphosphate
  • 5'-ITP
  • 5-ITP
  • Inosine 5
  • Inosine 5'-(tetrahydrogen triphosphate)
genes like me logo Genes that share compounds with ENTPD3: view

Transcripts for ENTPD3 Gene

Unigene Clusters for ENTPD3 Gene

Ectonucleoside triphosphate diphosphohydrolase 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENTPD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -

Relevant External Links for ENTPD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ENTPD3 Gene

mRNA expression in normal human tissues for ENTPD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENTPD3 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x7.2) and Brain - Caudate (basal ganglia) (x5.3).

Protein differential expression in normal tissues from HIPED for ENTPD3 Gene

This gene is overexpressed in Milk (45.8) and Amniocyte (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ENTPD3 Gene

SOURCE GeneReport for Unigene cluster for ENTPD3 Gene Hs.441145

mRNA Expression by UniProt/SwissProt for ENTPD3 Gene

Tissue specificity: Expressed in adult brain, pancreas, spleen and prostate. Moderate or low expression is seen in most tissues. Not expressed in liver and peripheral blood leukocytes
genes like me logo Genes that share expression patterns with ENTPD3: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ENTPD3 Gene

Orthologs for ENTPD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENTPD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ENTPD3 35
  • 86.09 (n)
  • 79.75 (a)
  • 76 (a)
(Canis familiaris)
Mammalia ENTPD3 35
  • 86.7 (n)
  • 82.61 (a)
  • 83 (a)
(Mus musculus)
Mammalia Entpd3 35
  • 83.3 (n)
  • 81.1 (a)
Entpd3 16
Entpd3 36
  • 81 (a)
(Pan troglodytes)
Mammalia ENTPD3 35
  • 99.62 (n)
  • 99.81 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Entpd3 35
  • 82.86 (n)
  • 81.66 (a)
(Monodelphis domestica)
Mammalia ENTPD3 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia ENTPD3 36
  • 73 (a)
(Gallus gallus)
Aves ENTPD3 35
  • 68.01 (n)
  • 64.26 (a)
  • 62 (a)
(Anolis carolinensis)
Reptilia ENTPD3 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia entpd3 35
  • 64.35 (n)
  • 63.5 (a)
(Danio rerio)
Actinopterygii entpd3 35
  • 57.61 (n)
  • 53.26 (a)
entpd3 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea mig-23 36
  • 19 (a)
ntp-1 36
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YND1 36
  • 17 (a)
Species with no ortholog for ENTPD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENTPD3 Gene

Gene Tree for ENTPD3 (if available)
Gene Tree for ENTPD3 (if available)

Paralogs for ENTPD3 Gene

Paralogs for ENTPD3 Gene

(12) SIMAP similar genes for ENTPD3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ENTPD3: view

Variants for ENTPD3 Gene

Sequence variations from dbSNP and Humsavar for ENTPD3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2305521 -- 40,387,692(+) CTGAA(A/G)AAAAG intron-variant
rs2305522 -- 40,387,867(+) ACATG(A/G)AATTT intron-variant
rs3774805 -- 40,388,585(+) ACACA(C/G)ACACA intron-variant
rs3774806 -- 40,388,642(+) CCCCG(A/C/G/T)CTGCC intron-variant
rs3774807 -- 40,388,732(+) TTACC(A/T)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENTPD3 Gene

Variant ID Type Subtype PubMed ID
nsv520025 CNV Loss 19592680
nsv876716 CNV Gain 21882294
esv2671271 CNV Deletion 23128226
nsv818137 CNV Loss 17921354

Variation tolerance for ENTPD3 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENTPD3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENTPD3 Gene

Disorders for ENTPD3 Gene

Relevant External Links for ENTPD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ENTPD3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENTPD3 Gene

Publications for ENTPD3 Gene

  1. Differential ectonucleotidase expression in human bladder cancer cell lines. (PMID: 19372055) Stella J. … Oliveira Battastini A.M. (Urol. Oncol. 2010) 23 67
  2. Cystic fibrosis remodels the regulation of purinergic signaling by NTPDase1 (CD39) and NTPDase3. (PMID: 20190036) Fausther M. … Picher M. (Am. J. Physiol. Lung Cell Mol. Physiol. 2010) 23 67
  3. Conserved polar residues stabilize transmembrane domains and promote oligomerization in human nucleoside triphosphate diphosphohydrolase 3. (PMID: 19743837) Gaddie K.J. … Kirley T.L. (Biochemistry 2009) 23 67
  4. Trafficking and intracellular ATPase activity of human ecto-nucleotidase NTPDase3 and the effect of ER-targeted NTPDase3 on protein folding. (PMID: 18693757) Ivanenkov V.V. … Kirley T.L. (Biochemistry 2008) 23 67
  5. Characterization of an alternative splice variant of human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): a possible modulator of nucleotidase activity and purinergic signaling. (PMID: 17126282) Crawford P.A. … Kirley T.L. (Arch. Biochem. Biophys. 2007) 23 67

Products for ENTPD3 Gene

Sources for ENTPD3 Gene

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