Aliases for ENTPD3 Gene
External Ids for ENTPD3 Gene
Previous Symbols for ENTPD3 Gene
This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014]
GeneCards Summary for ENTPD3 Gene
ENTPD3 (Ectonucleoside Triphosphate Diphosphohydrolase 3) is a Protein Coding gene. Diseases associated with ENTPD3 include mucocutaneous leishmaniasis. Among its related pathways are Epstein-Barr virus infection and Purine metabolism (KEGG). GO annotations related to this gene include nucleoside-triphosphatase activity and nucleoside-diphosphatase activity. An important paralog of this gene is ENTPD4.
UniProtKB/Swiss-Prot for ENTPD3 Gene
Has a threefold preference for the hydrolysis of ATP over ADP
Ectonucleotidases (also known as NTPDases, Ecto-ATPases, ectonucleoside triphosphate diphosphohydrolase) are ectoenymzes that hydrolyze extracellular nucleotides. There are four major families of ectonucleotidases: CD39/NTPDases (ecto-nucleotide triphosphate diphosphohydrolases); ecto-nucleotide pyrophosphatase phosphodiesterases (E-NPPs); alkaline phosphatases; and ecto-5-nucleotidases/CD73.