Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ENTPD3 Gene

Aliases for ENTPD3 Gene

  • Ectonucleoside Triphosphate Diphosphohydrolase 3 2 3
  • CD39L3 3 4 6
  • Ecto-ATP Diphosphohydrolase 3 3 4
  • CD39 Antigen-Like 3 3 4
  • Ecto-ATPDase 3 3 4
  • Ecto-Apyrase 3 3 4
  • Ecto-ATPase 3 3 4
  • EC 3.6.1.5 4 63
  • NTPDase 3 3 4
  • HB6 3 4
  • NTPDase-3 3
  • EC 3.6.1 63

External Ids for ENTPD3 Gene

Previous HGNC Symbols for ENTPD3 Gene

  • CD39L3

Previous GeneCards Identifiers for ENTPD3 Gene

  • GC03P039737
  • GC03P039656
  • GC03P040241
  • GC03P040389

Summaries for ENTPD3 Gene

Entrez Gene Summary for ENTPD3 Gene

  • This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014]

GeneCards Summary for ENTPD3 Gene

ENTPD3 (Ectonucleoside Triphosphate Diphosphohydrolase 3) is a Protein Coding gene. Diseases associated with ENTPD3 include mucocutaneous leishmaniasis. Among its related pathways are Epstein-Barr virus infection and Purine metabolism (KEGG). GO annotations related to this gene include nucleoside-triphosphatase activity and nucleoside-diphosphatase activity. An important paralog of this gene is ENTPD4.

UniProtKB/Swiss-Prot for ENTPD3 Gene

  • Has a threefold preference for the hydrolysis of ATP over ADP

Tocris Summary for ENTPD3 Gene

  • Ectonucleotidases (also known as NTPDases, Ecto-ATPases, ectonucleoside triphosphate diphosphohydrolase) are ectoenymzes that hydrolyze extracellular nucleotides. There are four major families of ectonucleotidases: CD39/NTPDases (ecto-nucleotide triphosphate diphosphohydrolases); ecto-nucleotide pyrophosphatase phosphodiesterases (E-NPPs); alkaline phosphatases; and ecto-5'-nucleotidases/CD73

Gene Wiki entry for ENTPD3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENTPD3 Gene

Genomics for ENTPD3 Gene

Regulatory Elements for ENTPD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ENTPD3 Gene

Start:
40,387,156 bp from pter
End:
40,428,619 bp from pter
Size:
41,464 bases
Orientation:
Plus strand

Genomic View for ENTPD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ENTPD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENTPD3 Gene

Proteins for ENTPD3 Gene

  • Protein details for ENTPD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75355-ENTP3_HUMAN
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 3
    Protein Accession:
    O75355
    Secondary Accessions:
    • B2R8D0
    • G5E9N0
    • O60495
    • Q8N6K2

    Protein attributes for ENTPD3 Gene

    Size:
    529 amino acids
    Molecular mass:
    59105 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ENTPD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENTPD3 Gene

Proteomics data for ENTPD3 Gene at MOPED

Selected DME Specific Peptides for ENTPD3 Gene

Post-translational modifications for ENTPD3 Gene

  • Glycosylation at Asn81, Asn149, Asn238, Asn381, Asn392, Asn402, and Asn454
  • Modification sites at PhosphoSitePlus

Other Protein References for ENTPD3 Gene

Antibody Products

  • R&D Systems Antibodies for ENTPD3 (CD39L3/ENTPD3)

Domains for ENTPD3 Gene

Protein Domains for ENTPD3 Gene

Suggested Antigen Peptide Sequences for ENTPD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75355

UniProtKB/Swiss-Prot:

ENTP3_HUMAN :
  • O75355
Family:
  • Belongs to the GDA1/CD39 NTPase family.
genes like me logo Genes that share domains with ENTPD3: view

No data available for Gene Families for ENTPD3 Gene

Function for ENTPD3 Gene

Molecular function for ENTPD3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: A nucleoside 5-triphosphate + 2 H(2)O = a nucleoside 5-phosphate + 2 phosphate
UniProtKB/Swiss-Prot Function: Has a threefold preference for the hydrolysis of ATP over ADP

Enzyme Numbers (IUBMB) for ENTPD3 Gene

Gene Ontology (GO) - Molecular Function for ENTPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity --
GO:0017110 nucleoside-diphosphatase activity IEA --
GO:0017111 nucleoside-triphosphatase activity IEA --
genes like me logo Genes that share ontologies with ENTPD3: view

Animal Model Products

CRISPR Products

miRNA for ENTPD3 Gene

miRTarBase miRNAs that target ENTPD3

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ENTPD3 Gene

Localization for ENTPD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENTPD3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ENTPD3 Gene COMPARTMENTS Subcellular localization image for ENTPD3 gene
Compartment Confidence
plasma membrane 3
extracellular 2
golgi apparatus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ENTPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ENTPD3: view

Pathways for ENTPD3 Gene

genes like me logo Genes that share pathways with ENTPD3: view

Pathways by source for ENTPD3 Gene

1 GeneGo (Thomson Reuters) pathway for ENTPD3 Gene

Gene Ontology (GO) - Biological Process for ENTPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0009134 nucleoside diphosphate catabolic process IEA --
GO:0009143 nucleoside triphosphate catabolic process IEA --
genes like me logo Genes that share ontologies with ENTPD3: view

Compounds for ENTPD3 Gene

(5) Tocris Compounds for ENTPD3 Gene

Compound Action Cas Number
Adenosine 5'-(alpha,beta-methylene)diphosphate sodium salt Ecto-5'-nucleotidase/ CD73 inhibitor [89016-30-8]
ARL 67156 trisodium salt Ecto-ATPase inhibitor [1021868-83-6]
POM 1 Inhibitor of E-NTPDases [12141-67-2]
PSB 06126 NTPDase 3 inhibitor [1052089-16-3]
PSB 069 Non-selective NTPDase inhibitor [78510-31-3]

(23) HMDB Compounds for ENTPD3 Gene

Compound Synonyms Cas Number PubMed IDs
5-Thymidylic acid
  • 2'-Deoxythymidine 5'-monophosphate
365-07-1
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2

(1) Novoseek inferred chemical compound relationships for ENTPD3 Gene

Compound -log(P) Hits PubMed IDs
atp 46.2 3
genes like me logo Genes that share compounds with ENTPD3: view

Transcripts for ENTPD3 Gene

Unigene Clusters for ENTPD3 Gene

Ectonucleoside triphosphate diphosphohydrolase 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENTPD3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ENTPD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2:
SP3:

Relevant External Links for ENTPD3 Gene

GeneLoc Exon Structure for
ENTPD3
ECgene alternative splicing isoforms for
ENTPD3

Expression for ENTPD3 Gene

mRNA expression in normal human tissues for ENTPD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENTPD3 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (7.2) and Brain - Caudate (basal ganglia) (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ENTPD3 Gene

SOURCE GeneReport for Unigene cluster for ENTPD3 Gene Hs.441145

mRNA Expression by UniProt/SwissProt for ENTPD3 Gene

O75355-ENTP3_HUMAN
Tissue specificity: Expressed in adult brain, pancreas, spleen and prostate. Moderate or low expression is seen in most tissues. Not expressed in liver and peripheral blood leukocytes
genes like me logo Genes that share expressions with ENTPD3: view

In Situ Assay Products

Orthologs for ENTPD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENTPD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ENTPD3 35
  • 99.62 (n)
  • 99.81 (a)
ENTPD3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ENTPD3 35
  • 86.09 (n)
  • 79.75 (a)
ENTPD3 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ENTPD3 35
  • 86.7 (n)
  • 82.61 (a)
ENTPD3 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Entpd3 35
  • 83.3 (n)
  • 81.1 (a)
Entpd3 16
Entpd3 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ENTPD3 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ENTPD3 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Entpd3 35
  • 82.86 (n)
  • 81.66 (a)
chicken
(Gallus gallus)
Aves ENTPD3 35
  • 68.01 (n)
  • 64.26 (a)
ENTPD3 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ENTPD3 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia entpd3 35
  • 64.35 (n)
  • 63.5 (a)
zebrafish
(Danio rerio)
Actinopterygii entpd3 35
  • 57.61 (n)
  • 53.26 (a)
entpd3 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mig-23 36
  • 19 (a)
ManyToMany
ntp-1 36
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YND1 36
  • 17 (a)
OneToMany
Species with no ortholog for ENTPD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENTPD3 Gene

ENSEMBL:
Gene Tree for ENTPD3 (if available)
TreeFam:
Gene Tree for ENTPD3 (if available)

Paralogs for ENTPD3 Gene

Paralogs for ENTPD3 Gene

Selected SIMAP similar genes for ENTPD3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ENTPD3: view

Variants for ENTPD3 Gene

Sequence variations from dbSNP and Humsavar for ENTPD3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2305521 -- 40,387,692(+) CTGAA(A/G)AAAAG intron-variant
rs2305522 -- 40,387,867(+) ACATG(A/G)AATTT intron-variant
rs3774805 -- 40,388,585(+) ACACA(C/G)ACACA intron-variant
rs3774806 -- 40,388,642(+) CCCCG(A/C/G/T)CTGCC intron-variant
rs3774807 -- 40,388,732(+) TTACC(A/T)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENTPD3 Gene

Variant ID Type Subtype PubMed ID
nsv520025 CNV Loss 19592680
nsv876716 CNV Gain 21882294
esv2671271 CNV Deletion 23128226
nsv818137 CNV Loss 17921354

Relevant External Links for ENTPD3 Gene

HapMap Linkage Disequilibrium report
ENTPD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENTPD3 Gene

Disorders for ENTPD3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ENTPD3 Gene including...

Search for ENTPD3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ENTPD3 Gene

genes like me logo Genes that share disorders with ENTPD3: view

No data available for UniProtKB/Swiss-Prot for ENTPD3 Gene

Publications for ENTPD3 Gene

  1. Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling. (PMID: 15966724) Ivanenkov V.V. … Kirley T.L. (Biochemistry 2005) 3 4 23
  2. The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster. (PMID: 9676430) Chadwick B.P. … Frischauf A.-M. (Genomics 1998) 2 3 4
  3. Mutagenesis of two conserved tryptophan residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto- NTPase. (PMID: 10231536) Smith T.M. … Kirley T.L. (Biochemistry 1999) 3 4
  4. Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions. (PMID: 11300774) Yang F. … Kirley T.L. (Biochemistry 2001) 3 4
  5. Conserved polar residues stabilize transmembrane domains and promote oligomerization in human nucleoside triphosphate diphosphohydrolase 3. (PMID: 19743837) Gaddie K.J. … Kirley T.L. (Biochemistry 2009) 3 23

Products for ENTPD3 Gene

Sources for ENTPD3 Gene

Back to Top

Content