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ENTPD3 Gene

protein-coding   GIFtS: 63
GCID: GC03P040403

Ectonucleoside Triphosphate Diphosphohydrolase 3


(Previous symbol: CD39L3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ectonucleoside Triphosphate Diphosphohydrolase 31 2     CD39 Antigen-Like 32 3
CD39L31 2 3 5     NTPDase 32 3
Ecto-Apyrase 32 3     EC 3.6.1.53 8
Ecto-ATP Diphosphohydrolase 32 3     NTPDase-32
Ecto-ATPase 32 3     CD39-Like 32
Ecto-ATPDase 32 3     EC 3.6.18
HB62 3     

External Ids:    HGNC: 33651   Entrez Gene: 9562   Ensembl: ENSG000001680327   OMIM: 6031615   UniProtKB: O753553   

Export aliases for ENTPD3 gene to outside databases

Previous GC identifers: GC03P039737 GC03P039656 GC03P040241 GC03P040389


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ENTPD3 Gene:
ENTPD3 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular
nucleotides. ENTPD3 contains 4 apyrase-conserved regions which is characteristic of NTPases. (provided by RefSeq,
Jul 2008)

GeneCards Summary for ENTPD3 Gene:
ENTPD3 (ectonucleoside triphosphate diphosphohydrolase 3) is a protein-coding gene. Diseases associated with ENTPD3 include mucocutaneous leishmaniasis, and labyrinthitis. GO annotations related to this gene include nucleoside-triphosphatase activity and nucleoside-diphosphatase activity. An important paralog of this gene is ENTPD1.

UniProtKB/Swiss-Prot: ENTP3_HUMAN, O75355
Function: Has a threefold preference for the hydrolysis of ATP over ADP

summary for ENTPD3 Gene:
Ectonucleotidases (also known as NTPDases, Ecto-ATPases, ectonucleoside triphosphate diphosphohydrolase) are
ectoenymzes that hydrolyze extracellular nucleotides. There are four major families of ectonucleotidases:
CD39/NTPDases (ecto-nucleotide triphosphate diphosphohydrolases); ecto-nucleotide pyrophosphatase
phosphodiesterases (E-NPPs); alkaline phosphatases; and ecto-5'-nucleotidases/CD73.

Gene Wiki entry for ENTPD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ENTPD3 gene promoter:
         AML1a   p300   Pax-6   Pax-2   FOXD1   Pax-2a   POU2F1   Pax-2b   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidENTPD3 promoter sequence
   Search Chromatin IP Primers for ENTPD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ENTPD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p21.3

ENTPD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ENTPD3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P040403:  view genomic region     (about GC identifiers)

Start:
40,428,647 bp from pter      End:
40,470,110 bp from pter
Size:
41,464 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ENTP3_HUMAN, O75355 (See protein sequence)
Recommended Name: Ectonucleoside triphosphate diphosphohydrolase 3  
Size: 529 amino acids; 59105 Da
Cofactor: Ca(2+) or Mg(2+)
Secondary accessions: B2R8D0 O60495

Explore the universe of human proteins at neXtProt for ENTPD3: NX_O75355

Explore proteomics data for ENTPD3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn81, Asn149, Asn238, Asn381, Asn392, Asn402, Asn454
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for ENTPD3 (O75355)
     PFDFRGA  TAGMRLL  KYGIVLD  DLGGASTQ 


    See ENTPD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001239.2  
    ENSEMBL proteins: 
     ENSP00000301825   ENSP00000406555   ENSP00000401565   ENSP00000404671  

    ENTPD3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000407 GDA1_CD39_NTPase

    Graphical View of Domain Structure for InterPro Entry O75355

    ProtoNet protein and cluster: O75355

    1 Blocks protein domain: IPB000407 GDA1/CD39 family of nucleoside phosphatase

    UniProtKB/Swiss-Prot: ENTP3_HUMAN, O75355
    Similarity: Belongs to the GDA1/CD39 NTPase family


    ENTPD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ENTP3_HUMAN, O75355
    Function: Has a threefold preference for the hydrolysis of ATP over ADP
    Catalytic activity: A nucleoside 5'-triphosphate + 2 H(2)O = a nucleoside 5'-phosphate + 2 phosphate

         Enzyme Numbers (IUBMB): EC 3.6.1.51 2 EC 3.6.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0016787hydrolase activity ----
    GO:0017110nucleoside-diphosphatase activity IEA--
    GO:0017111nucleoside-triphosphatase activity IEA--
         
    ENTPD3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ENTPD3
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    miRNA
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    miRTarBase miRNAs that target ENTPD3:
    hsa-mir-335-5p (MIRT017511), hsa-mir-192-5p (MIRT004160)

    Block miRNA regulation of human, mouse, rat ENTPD3 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate ENTPD3:
    hsa-miR-4314 hsa-miR-1233 hsa-miR-125a-5p hsa-miR-544b hsa-miR-1276 hsa-miR-125b hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidENTPD3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ENTPD3

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    GenScript: all cDNA clones in your preferred vector: ENTPD3 (NM_001248)
    Sino Biological Human cDNA Clone for ENTPD3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENTPD3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENTPD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ENTP3_HUMAN, O75355: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    golgi apparatus2
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    ENTPD3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ENTPD3 About    
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (KEGG)
    Purine metabolism0.38
    ATP ITP metabolism0.31
    Pyrimidine metabolism0.38
    2Epstein-Barr virus infection
    Epstein-Barr virus infection

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ENTPD3
        ATP/ITP metabolism



    3 Kegg Pathways  (Kegg details for ENTPD3):
        Purine metabolism
    Pyrimidine metabolism
    Epstein-Barr virus infection


    ENTPD3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ENTPD3
    Interactions:

        Search GeneGlobe Interaction Network for ENTPD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ENTPD3 (ENSP000003018254) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADKENSP000002866214STRING: ENSP00000286621
    AK2ENSP000003469214STRING: ENSP00000346921
    AK3ENSP000003712304STRING: ENSP00000371230
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009134nucleoside diphosphate catabolic process IEA--
    GO:0009143nucleoside triphosphate catabolic process IEA--

    ENTPD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ENTPD3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PSB 069Non-selective NTPDase inhibitor[78510-31-3]
    POM 1Inhibitor of E-NTPDases[12141-67-2]
    ARL 67156 trisodium saltEcto-ATPase inhibitor[160928-38-1]
    PSB 06126NTPDase 3 inhibitor[1052089-16-3]

    Selected HMDB Compounds for ENTPD3 (see all 23)    About this table
    CompoundSynonyms CAS #PubMed Ids
    5-Thymidylic acid2'-Deoxythymidine 5'-monophosphate (see all 28)365-07-1--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CDPCDP (see all 3)63-38-7--
    CalciumCa (see all 2)7440-70-2--
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    Cytidine triphosphatecytidine 5'-(tetrahydrogen triphosphate) (see all 15)65-47-4--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--

    1 Novoseek inferred chemical compound relationship for ENTPD3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 46.2 6 18693757 (2), 20190036 (1)



    ENTPD3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ENTPD3 gene: 
    NM_001248.2  

    Unigene Cluster for ENTPD3:

    Ectonucleoside triphosphate diphosphohydrolase 3
    Hs.441145  [show with all ESTs]
    Unigene Representative Sequence: AF034840
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301825(uc003ckd.4 uc010hhy.3) ENST00000439533 ENST00000456402
    ENST00000445129
    miRNA
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    Block miRNA regulation of human, mouse, rat ENTPD3 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate ENTPD3:
    hsa-miR-4314 hsa-miR-1233 hsa-miR-125a-5p hsa-miR-544b hsa-miR-1276 hsa-miR-125b hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidENTPD3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ENTPD3 (NM_001248)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ENTPD3
      QuantiTect SYBR Green Assays in human, mouse, rat ENTPD3
      QuantiFast Probe-based Assays in human, mouse, rat ENTPD3

    Additional mRNA sequence: 

    AF034840.2 AF039917.1 AK313322.1 BC029869.1 

    3 DOTS entries:

    DT.310787  DT.100019007  DT.120874594 

    Selected AceView cDNA sequences (see all 55):

    BQ722360 AI811360 CK903433 BC029869 BQ130030 BQ478211 BM671417 BQ272574 
    BM983002 AI669604 AI804671 CD244176 BQ285966 BU730218 BE875697 BM263316 
    N58878 AA463700 CB242834 BQ269324 AI290905 BM809031 AW407199 CD610970 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -                                                                 -         
    SP2:                                                                                          
    SP3:                                                                                          


    ECgene alternative splicing isoforms for ENTPD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ENTPD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTATATAT
    ENTPD3 Expression
    About this image


    ENTPD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Chondrocytes Zeugopod Epiphyseal End
             Zeugopod Long Bone
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             Chondrocytes Tracheal Cartilage
             Stem Bronchi
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Zeugopod Epiphyseal End
             Tracheal Cartilage
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
    ENTPD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ENTPD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.441145

    UniProtKB/Swiss-Prot: ENTP3_HUMAN, O75355
    Tissue specificity: Expressed in adult brain, pancreas, spleen and prostate. Moderate or low expression is seen in
    most tissues. Not expressed in liver and peripheral blood leukocytes

        Custom PCR Arrays for ENTPD3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENTPD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ENTPD3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Entpd31 , 5 ectonucleoside triphosphate diphosphohydrolase 31, 5 83.3(n)1
    81.1(a)1
      9 (71.71 cM)5
    2154461  NM_178676.41  NP_848791.21 
     1205398185 
    chicken
    (Gallus gallus)
    Aves ENTPD31 ectonucleoside triphosphate diphosphohydrolase 3 68.01(n)
    64.26(a)
      428447  XM_426007.3  XP_426007.3 
    lizard
    (Anolis carolinensis)
    Reptilia ENTPD36
    ectonucleoside triphosphate diphosphohydrolase 3
    66(a)
    1 ↔ 1
    6(36042512-36090024)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia entpd31 ectonucleoside triphosphate diphosphohydrolase 3 64.35(n)
    63.5(a)
      100125010  NM_001102938.1  NP_001096408.1 
    zebrafish
    (Danio rerio)
    Actinopterygii entpd31 ectonucleoside triphosphate diphosphohydrolase 3 57.61(n)
    53.26(a)
      100005551  NM_001083581.1  NP_001077050.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ntp-16
    mig-236
    Protein MIG-23 (mig-23) mRNA, complete cds
    22(a)
    19(a)
    many ↔ many
    many ↔ many
    IV(7792349-7794809) WBGene00016380
    X(5945821-5948869) WBGene00003254
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YND16
    Apyrase with wide substrate specificity, helps pre...
    17(a)
    1 → many
    V(160550-162442) YER005W


    ENSEMBL Gene Tree for ENTPD3 (if available)
    TreeFam Gene Tree for ENTPD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ENTPD3 gene
    ENTPD12  ENTPD72  ENTPD82  ENTPD22  ENTPD42  
    12 SIMAP similar genes for ENTPD3 using alignment to 3 protein entries:     ENTP3_HUMAN (see all proteins):
    SIPA1L3    DNAPTP3    KIAA1651    FLJ20555    FAM138C    OK/SW-cl.41
    ZNF195    FP6651    ENTPD2    ENTPD1    ENTPD8    ZNF843

    ENTPD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ENTPD3 (see all 109)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1397672771,2
    --40426688(+) CTTTTG/TTGTTC 1 -- us2k10--------
    rs1923458421,2
    --40426716(+) ATTCCC/TGTGCC 1 -- us2k10--------
    rs1847318171,2
    --40426785(+) AATCTG/TTATTA 1 -- us2k10--------
    rs1887539481,2
    --40426786(+) ATCTGC/TATTAT 1 -- us2k10--------
    rs3770821301,2
    C--40426834(+) TGTGT-/TGGTGTG 1 -- us2k10--------
    rs1813610191,2
    --40426854(+) TCTTGA/CATGTG 1 -- us2k10--------
    rs1445473571,2
    --40426858(+) GCATGC/TGGAAG 1 -- us2k10--------
    rs728616771,2
    C--40426911(+) AGCTGC/AAAAGG 1 -- us2k13Minor allele frequency- A:0.21WA 122
    rs794414821,2
    C,F--40427003(+) AGGAGG/ACTGAT 1 -- us2k11Minor allele frequency- A:0.15EA 120
    rs1150904161,2
    C,F--40427159(+) TGGGGA/GTGCTA 1 -- us2k11Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for ENTPD3 (40428647 - 40470110 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ENTPD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671271CNV Deletion23128226
    nsv818137CNV Loss17921354
    nsv520025CNV Loss19592680
    nsv876716CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ENTPD3
    DNA2.0 Custom Variant and Variant Library Synthesis for ENTPD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603161    OMIM disorders: --

    8 diseases for ENTPD3:    
    About MalaCards
    mucocutaneous leishmaniasis    labyrinthitis    primary ciliary dyskinesia    leishmaniasis
    cystic fibrosis    retinitis    cerebritis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ENTPD3:
    Mucocutaneous leishmaniasis

    ENTPD3 for disorders           About GeneDecksing


    Export disorders for ENTPD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ENTPD3 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with ENTPD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster. (PubMed id 9676430)1, 2, 3 Chadwick B.P. and Frischauf A.-M. (Genomics 1998)
    2. Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling. (PubMed id 15966724)1, 2, 9 Ivanenkov V.V....Kirley T.L. (Biochemistry 2005)
    3. Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions. (PubMed id 11300774)1, 2 Yang F.... Kirley T.L. (Biochemistry 2001)
    4. Mutagenesis of two conserved tryptophan residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto- NTPase. (PubMed id 10231536)1, 2 Smith T.M.... Kirley T.L. (Biochemistry 1999)
    5. Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases. (PubMed id 9675246)1, 2 Smith T.M. and Kirley T.L. (Biochim. Biophys. Acta 1998)
    6. Cystic fibrosis remodels the regulation of purinergic signaling by NTPDase1 (CD39) and NTPDase3. (PubMed id 20190036)1, 9 Fausther M....Picher M. (Am. J. Physiol. Lung Cell Mol. Physiol. 2010)
    7. Conserved polar residues stabilize transmembrane domains and promote oligomerization in human nucleoside triphosphate diphosphohydrolase 3. (PubMed id 19743837)1, 9 Gaddie K.J. and Kirley T.L. (Biochemistry 2009)
    8. Ectonucleotidase NTPDase3 is abundant in pancreatic I^-cells and regulates glucose-induced insulin secretion. (PubMed id 24085034)1 Syed S.K....Efanov A.M. (Am. J. Physiol. Endocrinol. Metab. 2013)
    9. Characterization of a monoclonal antibody as the first specific inhibitor of human NTP diphosphohydrolase-3 : partial characterization of the inhibitory epitope and potential applications. (PubMed id 19120451)1 Munkonda M.N....SAcvigny J. (FEBS J. 2009)
    10. Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists. (PubMed id 17727821)1 Munkonda M.N....SAcvigny J. (Biochem. Pharmacol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 956 HGNC: 3365 AceView: ENTPD3 Ensembl:ENSG00000168032 euGenes: HUgn956
    ECgene: ENTPD3 Kegg: 956 H-InvDB: ENTPD3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ENTPD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ENTPD3 gene:
    Search GeneIP for patents involving ENTPD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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