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Aliases for ENTPD2 Gene

Aliases for ENTPD2 Gene

  • Ectonucleoside Triphosphate Diphosphohydrolase 2 2 3 5
  • Ecto-ATP Diphosphohydrolase 2 3 4
  • CD39 Antigen-Like 1 3 4
  • Ecto-ATPDase 2 3 4
  • Ecto-ATPase 2 3 4
  • NTPDase 2 3 4
  • CD39L1 3 4
  • CD39-Like-1 2
  • Ecto-ATPase 2
  • EC 63
  • EC 3.6.1.- 4
  • NTPDase-2 3
  • EC 3.6.1 63

External Ids for ENTPD2 Gene

Previous HGNC Symbols for ENTPD2 Gene

  • CD39L1

Previous GeneCards Identifiers for ENTPD2 Gene

  • GC09M131164
  • GC09M131632
  • GC09M133383
  • GC09M135299
  • GC09M135300
  • GC09M137218
  • GC09M139062
  • GC09M139942
  • GC09M109402

Summaries for ENTPD2 Gene

Entrez Gene Summary for ENTPD2 Gene

  • The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for ENTPD2 Gene

ENTPD2 (Ectonucleoside Triphosphate Diphosphohydrolase 2) is a Protein Coding gene. Diseases associated with ENTPD2 include Cholera and Dentin Sensitivity. Among its related pathways are Pyrimidine metabolism (KEGG) and Taste transduction. GO annotations related to this gene include hydrolase activity and nucleoside-diphosphatase activity. An important paralog of this gene is ENTPD3.

UniProtKB/Swiss-Prot for ENTPD2 Gene

  • In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.

Tocris Summary for ENTPD2 Gene

  • Ectonucleotidases (also known as NTPDases, Ecto-ATPases, ectonucleoside triphosphate diphosphohydrolase) are constitutively expressed ectoenzymes that hydrolyze extracellular nucleotides. There are four known major families of ectonucleotidases.

Gene Wiki entry for ENTPD2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENTPD2 Gene

Genomics for ENTPD2 Gene

Regulatory Elements for ENTPD2 Gene

Enhancers for ENTPD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ENTPD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ENTPD2 Gene

137,048,098 bp from pter
137,054,069 bp from pter
5,972 bases
Minus strand

Genomic View for ENTPD2 Gene

Genes around ENTPD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENTPD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENTPD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENTPD2 Gene

Proteins for ENTPD2 Gene

  • Protein details for ENTPD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 2
    Protein Accession:
    Secondary Accessions:
    • O15464
    • Q5SPY6
    • Q5SPY7

    Protein attributes for ENTPD2 Gene

    495 amino acids
    Molecular mass:
    53665 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ENTPD2 Gene


neXtProt entry for ENTPD2 Gene

Proteomics data for ENTPD2 Gene at MOPED

Selected DME Specific Peptides for ENTPD2 Gene

Post-translational modifications for ENTPD2 Gene

  • Glycosylation at Asn 64, Asn 129, Asn 294, Asn 378, and Asn 443
  • Modification sites at PhosphoSitePlus

Other Protein References for ENTPD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ENTPD2 Gene

Protein Domains for ENTPD2 Gene

Suggested Antigen Peptide Sequences for ENTPD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GDA1/CD39 NTPase family.
  • Belongs to the GDA1/CD39 NTPase family.
genes like me logo Genes that share domains with ENTPD2: view

No data available for Gene Families for ENTPD2 Gene

Function for ENTPD2 Gene

Molecular function for ENTPD2 Gene

UniProtKB/Swiss-Prot Function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.

Enzyme Numbers (IUBMB) for ENTPD2 Gene

genes like me logo Genes that share phenotypes with ENTPD2: view

Animal Models for ENTPD2 Gene

MGI Knock Outs for ENTPD2:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ENTPD2 Gene

Localization for ENTPD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENTPD2 Gene

Isoform Long: Cell membrane; Multi-pass membrane protein.
Isoform Short: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Isoform gamma: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ENTPD2 Gene COMPARTMENTS Subcellular localization image for ENTPD2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
plasma membrane 5
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ENTPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031253 cell projection membrane IEA --
GO:0044297 cell body IEA --
genes like me logo Genes that share ontologies with ENTPD2: view

Pathways & Interactions for ENTPD2 Gene

genes like me logo Genes that share pathways with ENTPD2: view

Pathways by source for ENTPD2 Gene

2 KEGG pathways for ENTPD2 Gene
1 GeneGo (Thomson Reuters) pathway for ENTPD2 Gene

Gene Ontology (GO) - Biological Process for ENTPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009181 purine ribonucleoside diphosphate catabolic process IEA --
GO:0051260 protein homooligomerization IEA --
GO:0071222 cellular response to lipopolysaccharide IEA --
GO:0071356 cellular response to tumor necrosis factor IEA --
genes like me logo Genes that share ontologies with ENTPD2: view

No data available for SIGNOR curated interactions for ENTPD2 Gene

Drugs & Compounds for ENTPD2 Gene

(7) Drugs for ENTPD2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Guanosine triphosphate Experimental Pharma 0
calcium Nutra 0
Magnesium Nutra 0

(13) Additional Compounds for ENTPD2 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
Adenosine 5'-(alpha,beta-methylene)diphosphate sodium salt

(5) Tocris Compounds for ENTPD2 Gene

Compound Action Cas Number
Adenosine 5'-(alpha,beta-methylene)diphosphate sodium salt Ecto-5'-nucleotidase/ CD73 inhibitor 89016-30-8
ARL 67156 trisodium salt Ecto-ATPase inhibitor 1021868-83-6
POM 1 Inhibitor of E-NTPDases 12141-67-2
PSB 06126 NTPDase 3 inhibitor 1052089-16-3
PSB 069 Non-selective NTPDase inhibitor 78510-31-3
genes like me logo Genes that share compounds with ENTPD2: view

Transcripts for ENTPD2 Gene

Unigene Clusters for ENTPD2 Gene

Ectonucleoside triphosphate diphosphohydrolase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - -
SP2: -

Relevant External Links for ENTPD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ENTPD2 Gene

mRNA expression in normal human tissues for ENTPD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENTPD2 Gene

This gene is overexpressed in Nerve - Tibial (x5.3).

Protein differential expression in normal tissues from HIPED for ENTPD2 Gene

This gene is overexpressed in Spinal cord (50.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ENTPD2 Gene

SOURCE GeneReport for Unigene cluster for ENTPD2 Gene Hs.123036

mRNA Expression by UniProt/SwissProt for ENTPD2 Gene

Tissue specificity: Brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas. No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with ENTPD2: view

Protein tissue co-expression partners for ENTPD2 Gene

Primer Products

Orthologs for ENTPD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENTPD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ENTPD2 35
  • 85.25 (n)
  • 86.38 (a)
  • 87 (a)
(Canis familiaris)
Mammalia ENTPD2 35
  • 83.97 (n)
  • 82.22 (a)
  • 82 (a)
(Mus musculus)
Mammalia Entpd2 35
  • 83.1 (n)
  • 83.43 (a)
Entpd2 16
Entpd2 36
  • 83 (a)
(Pan troglodytes)
Mammalia ENTPD2 35
  • 98.65 (n)
  • 97.74 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Entpd2 35
  • 82.42 (n)
  • 82.42 (a)
(Monodelphis domestica)
Mammalia ENTPD2 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia ENTPD2 36
  • 55 (a)
(Gallus gallus)
Aves ENTPD2 35
  • 65.15 (n)
  • 59.23 (a)
  • 37 (a)
(Anolis carolinensis)
Reptilia ENTPD2 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia entpd2 35
  • 64.16 (n)
  • 60.5 (a)
Str.5534 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1360 35
(Danio rerio)
Actinopterygii entpd2a.1 35
  • 57.65 (n)
  • 52.52 (a)
entpd2a.1 36
  • 48 (a)
entpd2a.2 36
  • 50 (a)
entpd2b 36
  • 45 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.992 35
(Caenorhabditis elegans)
Secernentea mig-23 36
  • 17 (a)
ntp-1 36
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YND1 36
  • 17 (a)
Species with no ortholog for ENTPD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENTPD2 Gene

Gene Tree for ENTPD2 (if available)
Gene Tree for ENTPD2 (if available)

Paralogs for ENTPD2 Gene

Paralogs for ENTPD2 Gene

(3) SIMAP similar genes for ENTPD2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ENTPD2: view

Variants for ENTPD2 Gene

Sequence variations from dbSNP and Humsavar for ENTPD2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_050307 -
rs7848899 -- 137,050,200(+) CGCCT(A/G)TCCCT intron-variant
rs1568352 -- 137,055,524(+) CCCCC(A/C)CACAC upstream-variant-2KB
rs7860436 -- 137,050,172(+) CCTAC(C/T)CACGA intron-variant
rs113080211 -- 137,050,276(+) TGCCC(C/T)TACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENTPD2 Gene

Variant ID Type Subtype PubMed ID
nsv469918 CNV Loss 18288195
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8415n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
nsv894483 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894503 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8425n71 CNV Loss 21882294
nsv894514 CNV Loss 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
dgv8433n71 CNV Gain 21882294
nsv894550 CNV Gain 21882294
dgv8437n71 CNV Gain 21882294
dgv8438n71 CNV Loss 21882294
dgv8439n71 CNV Loss 21882294
dgv8440n71 CNV Loss 21882294
nsv894570 CNV Loss 21882294
dgv8441n71 CNV Loss 21882294
dgv8442n71 CNV Loss 21882294
dgv8443n71 CNV Loss 21882294
dgv8444n71 CNV Loss 21882294
nsv831761 CNV Loss 17160897
esv2520970 CNV Insertion 19546169

Variation tolerance for ENTPD2 Gene

Residual Variation Intolerance Score: 75.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ENTPD2 Gene

Disorders for ENTPD2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ENTPD2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • cholera - vibrio cholerae
dentin sensitivity
  • sensitive dentin
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ENTPD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ENTPD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ENTPD2 Gene

Publications for ENTPD2 Gene

  1. Cloning and mapping of a human and mouse gene with homology to ecto- ATPase genes. (PMID: 9271669) Chadwick B.P. … Frischauf A.-M. (Mamm. Genome 1997) 2 3 4 23 67
  2. Inhibition of human NTPDase 2 by modification of an intramembrane cysteine by p-chloromercuriphenylsulfonate and oxidative cross-linking of the transmembrane domains. (PMID: 18656957) Chiang W.C. … Knowles A.F. (Biochemistry 2008) 3 23
  3. Mutagenesis of lysine 62, asparagine 64, and conserved region 1 reduces the activity of human ecto-ATPase (NTPDase 2). (PMID: 17489562) Javed R. … Knowles A.F. (Biochemistry 2007) 3 23
  4. Regulation of P2Y1 receptor-mediated signaling by the ectonucleoside triphosphate diphosphohydrolase isozymes NTPDase1 and NTPDase2. (PMID: 15496502) Alvarado-Castillo C. … Boyer J.L. (Mol. Pharmacol. 2005) 3 23
  5. Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis. (PMID: 15651265) Dranoff J.A. … SAcvigny J. (J. Investig. Med. 2004) 3 23

Products for ENTPD2 Gene

Sources for ENTPD2 Gene