Aliases for ENTPD1 Gene
External Ids for ENTPD1 Gene
Previous HGNC Symbols for ENTPD1 Gene
Previous GeneCards Identifiers for ENTPD1 Gene
The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
GeneCards Summary for ENTPD1 Gene
ENTPD1 (Ectonucleoside Triphosphate Diphosphohydrolase 1) is a Protein Coding gene. Diseases associated with ENTPD1 include Spastic Paraplegia 64, Autosomal Recessive and Spastic Paraplegia 64. Among its related pathways are Pyrimidine metabolism (KEGG) and Epstein-Barr virus infection. GO annotations related to this gene include hydrolase activity and nucleoside-diphosphatase activity. An important paralog of this gene is ENSG00000282889.
UniProtKB/Swiss-Prot for ENTPD1 Gene
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.