Aliases for ENSG00000268173 Gene
Previous GeneCards Identifiers for ENSG00000268173 Gene
GeneCards Summary for ENSG00000268173 Gene
ENSG00000268173 is a Protein Coding gene. Diseases associated with ENSG00000268173 include Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 and Megalencephaly. An important paralog of this gene is PIK3R2.
UniProtKB/Swiss-Prot for ENSG00000268173 Gene
Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).