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ENSG00000237022 Gene

protein-coding   GIFtS: 13
GCID: GC06Ml31280          (predicted)

ENSG00000237022


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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HLAC3
MHC Class I Antigen Cw*13
MHC Class I Antigen Cw*143
MHC Class I Antigen Cw*163

External Ids:    Ensembl: ENSG000002370227   UniProtKB: P305103   UniProtKB: Q299603   UniProtKB: P304993   

Export aliases for ENSG00000237022 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ENSG00000237022 Gene:
ENSG00000237022 is a protein-coding gene.

UniProtKB/Swiss-Prot: 1C14_HUMAN, P30510 (see all)
Function: Involved in the presentation of foreign antigens to the immune system




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for ENSG00000237022
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ENSG00000237022


Genomic Location:
Chromosome:6   

Ensembl cytogenetic band:  HSCHR6_MHC_MANNp22.1   

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06Ml31280:       (about GC identifiers)

Start:
31,280,024 bp from start of contig ALT_REF_LOCI_4      End:
31,283,395 bp from start of contig ALT_REF_LOCI_4
Size:
3,372 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: 1C14_HUMAN, P30510 (See protein sequence)
Recommended Name: HLA class I histocompatibility antigen, Cw-14 alpha chain precursor  
Size: 366 amino acids; 40838 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O62879 O78178 Q29641 Q30192 Q9MY35 Q9TQJ5

UniProtKB/Swiss-Prot: 1C16_HUMAN, Q29960 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-16 alpha chain precursor  
Size: 366 amino acids; 40753 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O78091 O78202 Q29862 Q29959 Q9MY74 Q9MYI3 Q9TNZ8
Alternative splicing: 2 isoforms:  Q29960-1   Q29960-2   

UniProtKB/Swiss-Prot: 1C01_HUMAN, P30499 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, Cw-1 alpha chain precursor  
Size: 366 amino acids; 40965 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Secondary accessions: O02865 O19676 P30500 Q29986 Q9UQS9
Alternative splicing: 2 isoforms:  Q29960-1   Q29960-2   

Explore the universe of human proteins at neXtProt for ENSG00000237022: NX_P30499

Explore proteomics data for ENSG00000237022 at MOPED

Post-translational modifications: 

  • Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the
    protein for rapid degradation via the ubiquitin system (By similarity)1
  • Modification sites at neXtProt

  • See ENSG00000237022 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000388708   ENSP00000390282   ENSP00000390860   ENSP00000431347   ENSP00000393374  
     ENSP00000407494   ENSP00000448156  
    Reactome Protein details: P30499 Q29960 P30510

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS
     IPR011161 MHC_I-like_Ag-recog
     IPR011162 MHC_I/II-like_Ag-recog
     IPR001039 MHC_I_a_a1/a2

    Graphical View of Domain Structure for InterPro Entry P30510
    Graphical View of Domain Structure for InterPro Entry Q29960
    Graphical View of Domain Structure for InterPro Entry P30499

    ProtoNet protein and cluster: P30510

    3 Blocks protein domains:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type
    IPB010579 MHC_I


    UniProtKB/Swiss-Prot: 1C14_HUMAN, P30510
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C16_HUMAN, Q29960
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1C01_HUMAN, P30499
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Find genes that share domains with ENSG00000237022           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
    UniProtKB/Swiss-Prot Summary: 1C14_HUMAN, P30510 (see all)
    Function: Involved in the presentation of foreign antigens to the immune system

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042605peptide antigen binding ----
         
    Find genes that share ontologies with ENSG00000237022           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ENSG00000237022

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    1C14_HUMAN, P30510: Membrane; Single-pass type I membrane protein
    1C16_HUMAN, Q29960: Isoform 1: Cell membrane; Single-pass type I membrane protein
    1C16_HUMAN, Q29960: Isoform 2: Secreted
    1C01_HUMAN, P30499: Membrane; Single-pass type I membrane protein

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ----
    GO:0005576extracellular region ----
    GO:0005886plasma membrane ----
    GO:0005887integral component of plasma membrane ----
    GO:0012507ER to Golgi transport vesicle membrane ----

    Find genes that share ontologies with ENSG00000237022           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Find genes that share SuperPaths with ENSG00000237022           About GenesLikeMe

    Pathways by sourceSee SuperPaths
    Show all pathways


    Selected Reactome Pathways for ENSG00000237022 (see all 6)
        Endosomal/Vacuolar pathway
    Interferon alpha/beta signaling
    Interferon gamma signaling
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ENSG00000237022
    Interactions:

        Search GeneGlobe Interaction Network for ENSG00000237022

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ENSG00000237022 (ENSP000003902824) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B2MENSP000003408584STRING: ENSP00000340858
    GMPSENSP000004198514STRING: ENSP00000419851
    ENSG00000206435ENSP000003729754STRING: ENSP00000372975
    ENSG00000206452ENSP000003832454STRING: ENSP00000383245
    ENSG00000206493ENSP000003730914STRING: ENSP00000373091
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916positive regulation of T cell mediated cytotoxicity ----
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I ----
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent ----
    GO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent ----
    GO:0006955immune response ----

    Find genes that share ontologies with ENSG00000237022           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for ENSG00000237022 (1C01)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487551 ENST00000459694 ENST00000465497 ENST00000453809 ENST00000414249
    ENST00000419590 ENST00000488273 ENST00000438171(uc011gwq.2 uc011gwr.2 uc011gws.2)
    ENST00000495898 ENST00000437368(uc011gww.1) ENST00000480429(uc011gwv.1)
    ENST00000495207 ENST00000552865(uc011gwt.1)
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    ENSG00000237022 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ENSG00000237022 Protein Expression
        Custom PCR Arrays for ENSG00000237022
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for ENSG00000237022 (if available)
    TreeFam Gene Tree for ENSG00000237022 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    1C14_HUMAN, P30510: The following alleles of Cw-14 are known: Cw*14:02 (CB-1), Cw*14:03 (CX44) and Cw*14:04. The
    sequence shown is that of Cw*14:02
    1C16_HUMAN, Q29960: The following alleles of Cw-16 are known: Cw*16:01, Cw*16:02 (CW*CL10V) and Cw*16:04. The sequence
    shown is that of Cw*16:01
    1C01_HUMAN, P30499: The following alleles of Cw-1 are known: Cw*01:01 (Cw1.1), Cw*01:02 (Cw1.2), Cw*01:03 and Cw*01:04.
    The sequence shown is that of Cw*01:01

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ENSG00000237022 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ENSG00000237022)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cw*0103, a new allele encoding for a novel HLA-Cw1 split in the Japanese population. (PubMed id 9672159)2 Wang H.... Juji T. (Tissue Antigens 1998)
    2. HLA class I alleles of LCL 721 and 174 x CEM.T2 (T2). (PubMed id 7871529)2 Steinle A. and Schendel D.J. (Tissue Antigens 1994)
    3. The molecular basis for reactivity of anti-Cw1 and anti-Cw3 alloantisera with HLA-B46 haplotypes. (PubMed id 1384166)2 Zemmour J.... Parham P. (Tissue Antigens 1992)
    4. Complete nucleotide sequence of a unique HLA class I C locus product expressed on the human choriocarcinoma cell line BeWo. (PubMed id 2708822)2 Ellis S.A.... McMichael A.J. (J. Immunol. 1989)
    5. Isolation, expression, and the primary structure of HLA-Cw1 and HLA- Cw2 genes: evolutionary aspects. (PubMed id 3032784)2 Gussow D.... Ploegh H.L. (Immunogenetics 1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Ensembl:ENSG00000237022

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ENSG00000237022 gene:
    Search GeneIP for patents involving ENSG00000237022

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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