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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ENSG00000236759 Gene

protein-coding   GIFtS: 15
GCID: GC06Mj31835          (predicted)

ENSG00000236759


  Search for ENSG00000236759
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BAT83     Euchromatic Histone-Lysine N-Methyltransferase 23
C6orf303     H3-K9-HMTase 33
EC 2.1.1.-3     Histone H3-K9 Methyltransferase 33
EC 2.1.1.433     HLA-B-Associated Transcript 83
G9A3     Lysine N-Methyltransferase 1C3
KMT1C3     Protein G9a3
NG363     

External Ids:    Ensembl: ENSG000002367597   UniProtKB: Q96KQ73   

Export aliases for ENSG00000236759 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ENSG00000236759 Gene: 
ENSG00000236759 is a protein-coding gene.

UniProtKB/Swiss-Prot: EHMT2_HUMAN, Q96KQ7
Function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and
H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression
by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3
(H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA
replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the
histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities
function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX
and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates
non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1,
HDAC1, ERCC6, KLF12 and itself




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ENSG00000236759
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ENSG00000236759

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENSG00000236759


Genomic Location:
Chromosome:6   

Ensembl cytogenetic band:  HSCHR6_MHC_COXp21.33   

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06Mj31835:       (about GC identifiers)

Start:
31,835,086 bp from pter      End:
31,853,014 bp from pter
Size:
17,929 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EHMT2_HUMAN, Q96KQ7 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase EHMT2  
Size: 1210 amino acids; 132370 Da
Subunit: Heterodimer; heterodimerizes with EHMT1/GLP. Interacts with GFI1B and WIZ. Part of the E2F6.com-1 complex
in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EHMT1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Part of a
complex composed of TRIM28, HDAC1, HDAC2 and EHMT2. Interacts with UHRF1
Subcellular location: Nucleus. Chromosome. Note=Associates with euchromatic regions. Does not associate with
heterochromatin
Caution: While NG36 and G9a were originally thought to derive from 2 separate genes, all G9A transcripts also
contain the in frame coding sequence of NG36 (PubMed:11707778)
Caution: It is uncertain whether Met-1 or Met-21 is the initiator methionine
Sequence caution: Sequence=AAD21811.1; Type=Erroneous gene model prediction; Sequence=AAD21812.1; Type=Erroneous
gene model prediction; Sequence=AAH02686.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH09351.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH18718.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH20970.2; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=BAB63294.1; Type=Erroneous gene model prediction;
Sequence=BAB63295.1; Type=Erroneous gene model prediction; Sequence=CAA49491.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
4 PDB 3D structures from and Proteopedia for ENSG00000236759:
2O8J (3D)        3DM1 (3D)        3K5K (3D)        3RJW (3D)    
Secondary accessions: B0UZY2 Q14349 Q5JP83 Q5JQ92 Q5JQA1 Q5JQG3 Q6PK06 Q96MH5 Q96QD0 Q9UQL8
Q9Y331
Alternative splicing: 3 isoforms:  Q96KQ7-1   Q96KQ7-2   Q96KQ7-3   

Explore the universe of human proteins at neXtProt for ENSG00000236759: NX_Q96KQ7

Explore proteomics data for ENSG00000236759 at MOPED 

Post-translational modifications:

  • UniProtKB: Methylated at Lys-185; automethylated
  • View neXtProt modification sites for NX_Q96KQ7

  • ENSG00000236759 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ENSG00000236759 Protein Expression

    ENSEMBL proteins: 
     ENSP00000398286   ENSP00000403402   ENSP00000411035   ENSP00000392305   ENSP00000416771  
     ENSP00000446581  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005694chromosome ----

    ENSG00000236759 for ontologies           About GeneDecksing



    ENSG00000236759 Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR001214 SET_dom
     IPR003616 Post-SET_dom
     IPR020683 Ankyrin_rpt-contain_dom
     IPR003606 Pre-SET_Zn-bd_sub
     IPR007728 Pre-SET_dom

    Graphical View of Domain Structure for InterPro Entry Q96KQ7

    ProtoNet protein and cluster: Q96KQ7

    4 Blocks protein domains:
    IPB001214 Nuclear protein SET
    IPB002110 Ankyrin repeat signature
    IPB003606 Nuclear protein Zn2+-binding
    IPB003616 SET-related region


    UniProtKB/Swiss-Prot: EHMT2_HUMAN, Q96KQ7
    Domain: The SET domain mediates interaction with WIZ
    Domain: The ANK repeats bind H3K9me1 and H3K9me2
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine
    methyltransferase family. Suvar3-9 subfamily
    Similarity: Contains 7 ANK repeats
    Similarity: Contains 1 post-SET domain
    Similarity: Contains 1 pre-SET domain
    Similarity: Contains 1 SET domain


    ENSG00000236759 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EHMT2_HUMAN, Q96KQ7
    Function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and
    H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression
    by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3
    (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA
    replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the
    histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities
    function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX
    and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates
    non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1,
    HDAC1, ERCC6, KLF12 and itself
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

         Enzyme Numbers (IUBMB): EC 2.1.1.431 EC 2.1.1.-1

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding ----
    GO:0005515protein binding ----
    GO:0008270zinc ion binding ----
    GO:0016279protein-lysine N-methyltransferase activity ----
    GO:0018024histone-lysine N-methyltransferase activity ----
         
    ENSG00000236759 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ENSG00000236759

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/99 Interacting proteins for ENSG00000236759 (Q96KQ71, 2, 3 ENSP000003982864) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313I2D: score=1 
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ----
    GO:0006275regulation of DNA replication ----
    GO:0006306DNA methylation ----
    GO:0007130synaptonemal complex assembly ----
    GO:0007286spermatid development ----

    ENSG00000236759 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ENSG00000236759 (EHMT2)

    Search CenterWatch for drugs/clinical trials and news about ENSG00000236759 / EHMT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481372 ENST00000479567 ENST00000477385(uc011fio.2) ENST00000497104(uc011fip.2)
    ENST00000436403 ENST00000443951(uc011fiq.2) ENST00000420874 ENST00000450075(uc011fir.2 uc011fis.2)
    ENST00000420623 ENST00000459733 ENST00000495133 ENST00000495902(uc011fit.1)
    ENST00000552339
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene RNAi
    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ENSG00000236759
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See ENSG00000236759 Protein Expression from SPIRE MOPED and PaxDB

    UniProtKB/Swiss-Prot: EHMT2_HUMAN, Q96KQ7
    Tissue specificity: Expressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen
    and peripheral blood leukocytes and lower level in bone marrow

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    In Situ
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    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ENSG00000236759

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ENSG00000236759 (if available)
    TreeFam Gene Tree for ENSG00000236759 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ENSG00000236759
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ENSG00000236759 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with ENSG00000236759)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Histone H3 lysine 56 methylation regulates DNA replication through its interaction wwith PCNA. (PubMed id 22387026)2 Yu Y.... Grunstein M. (2012)
    2. Maintenance of silent chromatin through replication r equires SWI/SNF-like chromatin remodeler SMARCAD1. (PubMed id 21549307)2 Rowbotham S.P....Mermoud J.E. (2011)
    3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    4. G9a and Glp methylate lysine 373 in the tumor suppres sor p53. (PubMed id 20118233)2 Huang J....Berger S.L. (2010)
    5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    6. Structural biology of human H3K9 methyltransferases. (PubMed id 20084102)2 Wu H....Schapira M. (2010)
    7. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells. (PubMed id 19056828)2 Kim J.K....Pradhan S. (2009)
    10. Protein lysine methyltransferase G9a acts on non-histone targets. (PubMed id 18438403)2 Rathert P.... Jeltsch A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Ensembl:ENSG00000236759

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ENSG00000236759 gene:
    Search GeneIP for patents involving ENSG00000236759

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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