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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ENSG00000235657 Gene

protein-coding   GIFtS: 20
GCID: GC06Pk29899          (predicted)

ENSG00000235657


Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Aw-683     MHC Class I Antigen A*23
Aw-693     MHC Class I Antigen A*683
HLAA3     MHC Class I Antigen A*693
HLA Class I Histocompatibility Antigen, A-28 Alpha Chain3     

External Ids:    Ensembl: ENSG000002356577   UniProtKB: P018913   UniProtKB: P018923   UniProtKB: P103163   

Export aliases for ENSG00000235657 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ENSG00000235657 Gene: 
ENSG00000235657 is a protein-coding gene. Diseases associated with ENSG00000235657 include influenza, and t-cell leukemia.

UniProtKB/Swiss-Prot: 1A68_HUMAN, P01891 (see all)
Function: Involved in the presentation of foreign antigens to the immune system




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ENSG00000235657
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ENSG00000235657

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENSG00000235657


Genomic Location:
Chromosome:6   

Ensembl cytogenetic band:  HSCHR6_MHC_DBBp22.1   

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06Pk29899:       (about GC identifiers)

Start:
29,899,000 bp from pter      End:
29,903,640 bp from pter
Size:
4,641 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 1A68_HUMAN, P01891 (See protein sequence)
Recommended Name: HLA class I histocompatibility antigen, A-68 alpha chain precursor  
Size: 365 amino acids; 40909 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
3 PDB 3D structures from and Proteopedia for ENSG00000235657:
1HSB (3D)        1TMC (3D)        2HLA (3D)    
Secondary accessions: O19673 O19695 O19794 O19795 O43907 O77938 O98010 P10315 P79505 Q9MYA5
Q9MYC4 Q9TQG7 Q9TQN5 Q9UIN2

UniProtKB/Swiss-Prot: 1A02_HUMAN, P01892 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-2 alpha chain precursor  
Size: 365 amino acids; 40922 Da
Subunit: Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1
protein. Interacts with HTLV-1 accessory protein p12I
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=CAA41022.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown
extensively;
6/178 PDB 3D structures from and Proteopedia for ENSG00000235657 (see all 178):
1AKJ (3D)        1AO7 (3D)        1AQD (3D)        1B0G (3D)        1B0R (3D)        1BD2 (3D)    
Secondary accessions: O19619 P06338 P10313 P30444 P30445 P30446 P30514 Q29680 Q29837 Q29899
Q95352 Q95380 Q9TPX8 Q9TPX9 Q9TPY0 Q9TQH5 Q9TQI3

UniProtKB/Swiss-Prot: 1A69_HUMAN, P10316 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, A-69 alpha chain precursor  
Size: 365 amino acids; 40977 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8
MIR1 protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: B1PKZ3

Explore the universe of human proteins at neXtProt for ENSG00000235657: NX_P10316

Explore proteomics data for ENSG00000235657 at MOPED 

Post-translational modifications:

  • UniProtKB: Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the
    protein for rapid degradation via the ubiquitin system (By similarity)
  • UniProtKB: Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1 protein. This targets
    the protein for rapid degradation via the ubiquitin system
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P10316

  • ENSG00000235657 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ENSG00000235657 Protein Expression

    ENSEMBL proteins: 
     ENSP00000403575   ENSP00000388526   ENSP00000392547   ENSP00000447962  
    Reactome Protein details: P01891 P10316 P01892
    Human Recombinant Protein Products for ENSG00000235657: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ----
    GO:0005886plasma membrane ----
    GO:0012507ER to Golgi transport vesicle membrane ----
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    ENSG00000235657 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro protein domains (see all 8):
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS
     IPR011161 MHC_I-like_Ag-recog
     IPR011162 MHC_I/II-like_Ag-recog
     IPR001039 MHC_I_a_a1/a2

    Graphical View of Domain Structure for InterPro Entry P01891
    Graphical View of Domain Structure for InterPro Entry P01892
    Graphical View of Domain Structure for InterPro Entry P10316

    ProtoNet protein and cluster: P01891

    3 Blocks protein domains:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type
    IPB010579 MHC_I


    UniProtKB/Swiss-Prot: 1A68_HUMAN, P01891
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A02_HUMAN, P01892
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 1A69_HUMAN, P10316
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    ENSG00000235657 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
    UniProtKB/Swiss-Prot Summary: 1A68_HUMAN, P01891 (see all)
    Function: Involved in the presentation of foreign antigens to the immune system

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005515protein binding ----
         
    ENSG00000235657 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    Pathways by sourceSee SuperPaths
    Show all pathways


    5/18        Reactome Pathways for ENSG00000235657 (see all 18)
        Endosomal/Vacuolar pathway
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Interferon alpha/beta signaling
    The role of Nef in HIV-1 replication and disease pathogenesis
    ER-Phagosome pathway



    ENSG00000235657 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ENSG00000235657

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/165 Interacting proteins for ENSG00000235657 (P018912 ENSP000003885264 P018922, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 165)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-DRB1P042292, ENSP000003530994MINT-8407259 MINT-8407185 STRING: ENSP00000353099
    PDIA3P301012, ENSP000003002894MINT-4653981 STRING: ENSP00000300289
    ANXA6P081332MINT-8407259 MINT-8407185
    B2MP617692, ENSP000003408584MINT-24957 STRING: ENSP00000340858
    CD81P600332MINT-8407259 MINT-8407185
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I ----
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent ----
    GO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent ----
    GO:0006955immune response ----
    GO:0016032viral process ----

    ENSG00000235657 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ENSG00000235657 (1A69)

    Search CenterWatch for drugs/clinical trials and news about ENSG00000235657 / 1A69

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000457879(uc011fur.2) ENST00000438861 ENST00000468666(uc011fut.2 uc011fuk.2)
    ENST00000453975 ENST00000487534(uc011fup.2 uc011fuq.2) ENST00000460542(uc021zmw.1 uc011fus.1)
    ENST00000470534 ENST00000547271
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ENSG00000235657 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ENSG00000235657 Expression
    About this image


    See ENSG00000235657 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for ENSG00000235657
    Primer
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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ENSG00000235657

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ENSG00000235657 (if available)
    TreeFam Gene Tree for ENSG00000235657 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ENSG00000235657 gene

    ENSG00000235657 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ENSG00000235657
    PGOHUM00000261435


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: 1A69_HUMAN, P10316
    Polymorphism: The following alleles of A-68 are known: A*68:01 (Aw68.1), A*68:02, A*68:03. A*68:04, A*68:05,
    A*68:06, A*68:07, A*68:08, A*68:09, A*68:10, A*68:16 and A*68:17. The sequence shown is that of A*68:01
    Polymorphism: The following alleles of A-2 are known: A*02:01, A*02:02, A*02:03, A*02:04, A*02:05, A*02:06
    (A2.4A), A*02:07, A*02:08, A*02:09, A*02:10, A*02:11 (A2.5), A*02:12, A*02:13 (A*02SLU), A*02:16, A*02:17,
    A*02:18 (A2K), A*02:19, A*02:20, A*02:21, A*02:31, A*02:34 (A*AAT), A*02:35, A*02:36 and A*02:37. The sequence
    shown is that of A*02:01
    Polymorphism: The only allele of A-69 known is A*69:01 which is shown here

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for ENSG00000235657:    About MalaCards
    influenza    t-cell leukemia    leukemia


    ENSG00000235657 for disorders           About GeneDecksing


    Export disorders for ENSG00000235657 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ENSG00000235657 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ENSG00000235657)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    2. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    3. Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (2008)
    4. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    5. Exon shuffling in vivo can generate novel HLA class I molecules. (PubMed id 3877632)2 Holmes N. and Parham P. (1985)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Ensembl:ENSG00000235657

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ENSG00000235657 gene:
    Search GeneIP for patents involving ENSG00000235657

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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