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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ENSG00000230885 Gene

protein-coding   GIFtS: 14
GCID: GC06Pl29624          (predicted)

ENSG00000230885


  Search for ENSG00000230885
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section


External Ids:    Ensembl: ENSG000002308857   UniProtKB: Q166533   

Export aliases for ENSG00000230885 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ENSG00000230885 Gene: 
ENSG00000230885 is a protein-coding gene.

UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653
Function: Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be
involved in completion and/or maintenance of the myelin sheath and in cell-cell communication




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ENSG00000230885
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ENSG00000230885

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENSG00000230885


Genomic Location:
Chromosome:6   

Ensembl cytogenetic band:  HSCHR6_MHC_MANNp22.1   

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06Pl29624:       (about GC identifiers)

Start:
29,624,321 bp from pter      End:
29,639,709 bp from pter
Size:
15,389 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653 (See protein sequence)
Recommended Name: Myelin-oligodendrocyte glycoprotein precursor  
Size: 247 amino acids; 28193 Da
Subunit: Homodimer (By similarity). May form heterodimers between the different isoforms
Subcellular location: Isoform 1: Cell membrane; Multi-pass membrane protein (Potential)
Subcellular location: Isoform 5: Cell membrane; Multi-pass membrane protein (Potential)
Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 3: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 4: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 6: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 7: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 8: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 9: Cell membrane; Single-pass type I membrane protein (Potential)
Caution: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG)
1 PDB 3D structure from and Proteopedia for ENSG00000230885:
1Q70 (3D)    
Secondary accessions: A6NDR4 A8MY31 B0UZR9 E9PGF0 F8W9D5 O00713 O00714 O00715 Q13054 Q13055
Q14855 Q29ZN8 Q56UY0 Q5JNX7 Q5JNY1 Q5JNY4 Q5SSB5 Q5SSB6 Q5STL9 Q5STM0 Q5STM5 Q5SUK7 Q5SUK8
Q5SUK9 Q5SUL0 Q5SUL1 Q92891 Q92892 Q92893 Q92894 Q92895 Q93053 Q96KU9 Q96KV0 Q96KV1 Q99605
Alternative splicing: 12 isoforms:  Q16653-1   Q16653-2   Q16653-3   Q16653-4   Q16653-5   Q16653-6   Q16653-7   Q16653-8   
Q16653-9   Q16653-10   Q16653-11   Q16653-12   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ENSG00000230885: NX_Q16653

Explore proteomics data for ENSG00000230885 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16653

  • ENSG00000230885 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ENSG00000230885 Protein Expression

    ENSEMBL proteins: 
     ENSP00000414489   ENSP00000390632   ENSP00000410699   ENSP00000404362   ENSP00000409534  
     ENSP00000402139   ENSP00000390469   ENSP00000413370   ENSP00000407143   ENSP00000447214  
     ENSP00000446871   ENSP00000448164   ENSP00000448364  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0016021integral to membrane ----

    ENSG00000230885 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR016663 Myelin-oligodendrocyte_glycop
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q16653

    ProtoNet protein and cluster: Q16653

    1 Blocks protein domain: IPB003596 Immunoglobulin V-type

    UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    ENSG00000230885 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOG_HUMAN, Q16653
    Function: Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be
    involved in completion and/or maintenance of the myelin sheath and in cell-cell communication

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    ENSG00000230885 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ENSG00000230885

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/10 Interacting proteins for ENSG00000230885 (Q166533 ENSP000003906324) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRNPP041563I2D: score=3 
    GRB2P629933I2D: score=2 
    OTUD4Q018043I2D: score=2 
    DLG4P783523I2D: score=1 
    GRIN2BQ132243I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion ----
    GO:0007417central nervous system development ----
    GO:0034126positive regulation of MyD88-dependent toll-like receptor signaling pathway ----

    ENSG00000230885 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ENSG00000230885 (MOG)

    Search CenterWatch for drugs/clinical trials and news about ENSG00000230885 / MOG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427289 ENST00000482220 ENST00000423895(uc011gpd.2) ENST00000472743
    ENST00000426782 ENST00000421125 ENST00000440561 ENST00000457626 ENST00000444674
    ENST00000458179 ENST00000440073 ENST00000493966 ENST00000478704 ENST00000548521(uc011gpq.2)
    ENST00000551993(uc011gpi.2 uc011gph.2 uc011gpm.2 uc011gpo.2 uc011gpn.2 uc011gpp.2)
    ENST00000551326 ENST00000547293(uc011gpa.2 uc011gpb.2 uc011gpc.2 uc011gpg.2 uc011gpf.2 uc011gpk.2 uc011gpl.2)

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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See ENSG00000230885 Protein Expression from SPIRE MOPED and PaxDB

    UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653
    Tissue specificity: Found exclusively in the CNS, where it is localized on the surface of myelin and
    oligodendrocyte cytoplasmic membranes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ENSG00000230885 (if available)
    TreeFam Gene Tree for ENSG00000230885 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ENSG00000230885 for disorders           About MalaCards
    UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653
  • Narcolepsy 7 (NRCLP7) [MIM:614250]: Neurological disabling sleep disorder, characterized by excessive
    daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy,
    hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions,
    which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a
    sporadically occurring disorder but familial clustering has been observed. Note=The disease is caused by
    mutations affecting the gene represented in this entry


  • ENSG00000230885 for disorders           About GeneDecksing


    Export disorders for ENSG00000230885 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ENSG00000230885 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ENSG00000230885)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A missense mutation in myelin oligodendrocyte glycoprotein as a cause of familial narcolepsy with cataplexy. (PubMed id 21907016)2 Hor H....Peraita-Adrados R. (2011)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    3. A conformational study of the human and rat encephalitogenic myelin oligodendrocyte glycoprotein peptides 35-55. (PubMed id 9210466)2 Albouz-Abo S.... von Itzstein M. (1997)
    4. Myelin/oligodendrocyte glycoprotein is alternatively spliced in humans but not mice. (PubMed id 8915905)2 Ballenthin P.A. and Gardinier M.V. (1996)
    5. Structure of the human myelin/oligodendrocyte glycoprotein gene and multiple alternative spliced isoforms. (PubMed id 8666381)2 Pham-Dinh D.... Dautigny A. (1995)
    6. The human myelin oligodendrocyte glycoprotein (MOG) gene: complete nucleotide sequence and structural characterization. (PubMed id 8530032)2 Roth M.-P.... Coppin H. (1995)
    7. Characterization of cDNA and genomic clones encoding human myelin oligodendrocyte glycoprotein. (PubMed id 7790876)2 Hilton A.A.... Bernard C.C.A. (1995)
    8. Characterization and expression of the cDNA coding for the human myelin/oligodendrocyte glycoprotein. (PubMed id 7964757)2 Pham-Dinh D.... Dautigny A. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Ensembl:ENSG00000230885

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    Wikipedia http://en.wikipedia.org/wiki/Myelin_oligodendrocyte_glycoprotein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ENSG00000230885 gene:
    Search GeneIP for patents involving ENSG00000230885

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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