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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ENSG00000230514 Gene

protein-coding   GIFtS: 17
GCID: GC06Mm32225          (predicted)

ENSG00000230514


  Search for ENSG00000230514
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAGE3
Receptor For Advanced Glycosylation End Products3

External Ids:    Ensembl: ENSG000002305147   UniProtKB: Q151093   

Export aliases for ENSG00000230514 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ENSG00000230514 Gene: 
ENSG00000230514 is a protein-coding gene.

UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109
Function: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically
glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts
as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in
particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the
production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction
with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with
generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role
in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta
peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the
extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially
stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system
delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ENSG00000230514
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ENSG00000230514 promoter sequence
   Search SABiosciences Chromatin IP Primers for ENSG00000230514

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENSG00000230514


Genomic Location:
Chromosome:6   

Ensembl cytogenetic band:  HSCHR6_MHC_MCFp21.32   

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06Mm32225:       (about GC identifiers)

Start:
32,225,175 bp from pter      End:
32,228,531 bp from pter
Size:
3,357 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109 (See protein sequence)
Recommended Name: Advanced glycosylation end product-specific receptor precursor  
Size: 404 amino acids; 42803 Da
Subunit: Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
6/11 PDB 3D structures from and Proteopedia for ENSG00000230514 (see all 11):
1PWI (3D)        2BJP (3D)        2E5E (3D)        2ENS (3D)        2L7U (3D)        2LE9 (3D)    
Secondary accessions: A2BFI7 A6NKF0 B0V176 Q15279 Q3L1R7 Q86SN1 Q9H2X7 Q9Y3R3
Alternative splicing: 4 isoforms:  Q15109-1   Q15109-2   Q15109-3   Q15109-4   

Explore the universe of human proteins at neXtProt for ENSG00000230514: NX_Q15109

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15109

  • ENSG00000230514 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

    ENSEMBL proteins: 
     ENSP00000397777   ENSP00000403322   ENSP00000415144   ENSP00000388041   ENSP00000397350  
     ENSP00000448142   ENSP00000449754   ENSP00000446533   ENSP00000446660   ENSP00000449731  
     ENSP00000449997  
    Reactome Protein details: Q15109
    Human Recombinant Protein Products for ENSG00000230514: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane ----
    GO:0016020membrane ----

    ENSG00000230514 for ontologies           About GeneDecksing



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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR013162 CD80_C2-set
     IPR003006 Ig/MHC_CS
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q15109

    ProtoNet protein and cluster: Q15109

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    ENSG00000230514 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAGE_HUMAN, Q15109
    Function: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically
    glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts
    as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in
    particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the
    production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction
    with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with
    generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role
    in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta
    peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the
    extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially
    stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system
    delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0004888transmembrane signaling receptor activity ----
    GO:0005515protein binding ----
    GO:0044548S100 protein binding ----
         
    ENSG00000230514 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ENSG00000230514 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    Pathways by sourceSee SuperPaths
    Show all pathways


    3        Reactome Pathways for ENSG00000230514
        Advanced glycosylation endproduct receptor signaling
    Immune System
    Innate Immune System



    ENSG00000230514 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ENSG00000230514

    5/14 Interacting proteins for ENSG00000230514 (Q151091, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    S100BP042712, 3MINT-5224202 MINT-5224259 MINT-5224222 MINT-5224235 I2D: score=2 
    TTRP027662, 3MINT-2635425 MINT-2635447 I2D: score=2 
    RHOAP615862, 3MINT-7301186 MINT-7301204 I2D: score=1 
    S100PP258151, 3EBI-1646426,EBI-743700 I2D: score=3 
    GRB2P629931, 3EBI-1646426,EBI-401755 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response ----
    GO:0007166cell surface receptor signaling pathway ----
    GO:0009611response to wounding ----
    GO:0031175neuron projection development ----
    GO:0045087innate immune response ----

    ENSG00000230514 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ENSG00000230514 (RAGE)

    Search CenterWatch for drugs/clinical trials and news about ENSG00000230514 / RAGE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484341 ENST00000476747 ENST00000485739 ENST00000448768 ENST00000452945(uc011hym.2 uc011hyi.2 uc021zsm.1 uc011hyr.2 uc011hyq.2 uc011hyh.2)
    ENST00000467684(uc021zsh.1 uc021zsi.1 uc021zsj.1 uc021zsk.1 uc021zsl.1 uc011hyf.2 uc011hye.2 uc011hyd.2)
    ENST00000426138(uc011hyk.2 uc011hyn.2 uc011hyp.2 uc011hyl.2 uc011hyj.2 uc011hyg.2 uc011hyo.2)
    ENST00000436653 ENST00000412794 ENST00000552209 ENST00000546535 ENST00000550441
    ENST00000552891 ENST00000549227 ENST00000548009
    miRNA
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    Inhib. RNA
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      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENSG00000230514

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    UniProtKB/Swiss-Prot: RAGE_HUMAN, Q15109
    Tissue specificity: Endothelial cells

        SABiosciences Custom PCR Arrays for ENSG00000230514
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    In Situ
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    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ENSG00000230514

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ENSG00000230514 (if available)
    TreeFam Gene Tree for ENSG00000230514 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ENSG00000230514
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ENSG00000230514 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ENSG00000230514)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. S100A14 stimulates cell proliferation and induces cel l apoptosis at different concentrations via receptor for advanced glycation end products (RAGE). (PubMed id 21559403)2 Jin Q....Liu Z. (2011)
    2. Advanced glycation end product recognition by the rec eptor for AGEs. (PubMed id 21565706)2 Xue J....Shekhtman A. (2011)
    3. The 1.5 A8 crystal structure of human receptor for adv anced glycation endproducts (RAGE) ectodomains reveals unique features determin ing ligand binding. (PubMed id 20943659)2 Park H. and Boyington J.C. (2010)
    4. Structural basis for ligand recognition and activatio n of RAGE. (PubMed id 20947022)2 Koch M....Fritz G. (2010)
    5. Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function. (PubMed id 19386136)2 Moroz O.V....Bronstein I.B. (2009)
    6. RAGE-dependent signaling in microglia contributes to neuroinflammation, A{beta} accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. (PubMed id 19906677)2 Fang F.... Yan S.S. (2009)
    7. Identification, classification, and expression of RAGE gene splice variants. (PubMed id 18089847)2 Hudson B.I.... Schmidt A.M. (2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    10. Novel splice variants of the receptor for advanced glycation end- products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. (PubMed id 12495433)2 Yonekura H.... Yamamoto H. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Ensembl:ENSG00000230514

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for ENSG00000230514 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ENSG00000230514 gene:
    Search GeneIP for patents involving ENSG00000230514

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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