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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ENSG00000224501 Gene

protein-coding   GIFtS: 17
GCID: GC06Pj31782          (predicted)

ENSG00000224501


  Search for ENSG00000224501
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
HSP70-1/HSP70-23
HSP70.1/HSP70.23
HSPA13
Heat Shock 70 KDa Protein 1/23

External Ids:    Ensembl: ENSG000002245017   UniProtKB: P081073   

Export aliases for ENSG00000224501 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ENSG00000224501 Gene: 
ENSG00000224501 is a protein-coding gene.

UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
chaperones participate in all these processes through their ability to recognize nonnative conformations of other
proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection,
serves as a post-attachment receptor for the virus to facilitate entry into the cell




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ENSG00000224501
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ENSG00000224501

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENSG00000224501


Genomic Location:
Chromosome:6   

Ensembl cytogenetic band:  HSCHR6_MHC_COXp21.33   

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06Pj31782:       (about GC identifiers)

Start:
31,782,890 bp from pter      End:
31,785,413 bp from pter
Size:
2,524 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107 (See protein sequence)
Recommended Name: Heat shock 70 kDa protein 1A/1B  
Size: 641 amino acids; 70052 Da
Subunit: Component of the CatSper complex (By similarity). Identified in a mRNP granule complex, at least composed
of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1,
ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and
untranslated mRNAs. Interacts with TSC2. Interacts with IRAK1BP1. Interacts with TERT; the interaction occurs in
the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with DNAJC7.
Interacts with CHCHD3. Interacts with TRIM5 (via B30.2/SPRY domain)
Subcellular location: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
6/14 PDB 3D structures from and Proteopedia for ENSG00000224501 (see all 14):
1HJO (3D)        1S3X (3D)        1XQS (3D)        2E88 (3D)        2E8A (3D)        2LMG (3D)    
Secondary accessions: B4E3B6 P19790 Q5JQI4 Q5SP17 Q9UQL9 Q9UQM0
Alternative splicing: 2 isoforms:  P08107-1   P08107-2   

Explore the universe of human proteins at neXtProt for ENSG00000224501: NX_P08107

Explore proteomics data for ENSG00000224501 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08107

  • ENSG00000224501 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ENSG00000224501 Protein Expression

    ENSEMBL proteins: 
     ENSP00000375391  
    Reactome Protein details: P08107
    Human Recombinant Protein Products for ENSG00000224501: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ----
    GO:0005783endoplasmic reticulum ----
    GO:0005829cytosol ----

    ENSG00000224501 for ontologies           About GeneDecksing



    ENSG00000224501 Antibody Products: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P08107

    ProtoNet protein and cluster: P08107

    1 Blocks protein domain: IPB001023 Heat shock protein Hsp70

    UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
    Similarity: Belongs to the heat shock protein 70 family


    ENSG00000224501 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSP71_HUMAN, P08107
    Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
    mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
    chaperones participate in all these processes through their ability to recognize nonnative conformations of other
    proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
    translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection,
    serves as a post-attachment receptor for the virus to facilitate entry into the cell
    Induction: By heat shock

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005524ATP binding ----
    GO:0031625ubiquitin protein ligase binding ----
    GO:0044183protein binding involved in protein folding ----
    GO:0047485protein N-terminus binding ----
         
    ENSG00000224501 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    Pathways by sourceSee SuperPaths
    Show all pathways


    5        Reactome Pathways for ENSG00000224501
        Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
    Destabilization of mRNA by AUF1 (hnRNP D0)
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression



    ENSG00000224501 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ENSG00000224501

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/571 Interacting proteins for ENSG00000224501 (P081071, 2, 3 ENSP000003753914) via UniProtKB, MINT, STRING, and/or I2D (see all 571)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNCAP378402, 3MINT-7557217 MINT-7555062 MINT-7556887 MINT-8211515 MINT-8211560 MINT-7556911 MINT-7556921 MINT-7556901 MINT-8211605 I2D: score=2 
    STUB1Q9UNE71, 2, 3EBI-629985,EBI-357085 MINT-7903424 I2D: score=4 
    AIFM1O958312, 3MINT-13840 MINT-13841 MINT-8079030 I2D: score=7 
    BAG1Q999332, 3MINT-45860 MINT-45859 MINT-7264729 I2D: score=4 
    HSP90AB1P082382, 3MINT-72641 MINT-8378890 MINT-8086576 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0006402mRNA catabolic process ----
    GO:0006986response to unfolded protein ----
    GO:0008285negative regulation of cell proliferation ----
    GO:0010467gene expression ----

    ENSG00000224501 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for ENSG00000224501:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ENSG00000224501 (HSP71)

    Search CenterWatch for drugs/clinical trials and news about ENSG00000224501 / HSP71

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000391548(uc011fhy.1)
    miRNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENSG00000224501

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See ENSG00000224501 Protein Expression from SPIRE MOPED and PaxDB

    UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
    Tissue specificity: HSPA1B is testis-specific

        SABiosciences Custom PCR Arrays for ENSG00000224501
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    In Situ
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    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ENSG00000224501

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ENSG00000224501 (if available)
    TreeFam Gene Tree for ENSG00000224501 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ENSG00000224501 gene

    ENSG00000224501 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ENSG00000224501
    PGOHUM00000259622


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ENSG00000224501
    DNA2.0 Custom Variant and Variant Library Synthesis for ENSG00000224501

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ENSG00000224501 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with ENSG00000224501)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)2 Cloutier P.... Coulombe B. (2013)
    2. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. (PubMed id 21081504)2 Darshi M.... Taylor S.S. (2011)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    5. Hsp70 interacts with the retroviral restriction facto r TRIM5alpha and assists the folding of TRIM5alpha. (PubMed id 20053985)2 Hwang C.Y....Song B. (2010)
    6. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    7. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    8. Role of the cochaperone Tpr2 in Hsp90 chaperoning. (PubMed id 18620420)2 Moffatt N.S.... Toft D. (2008)
    9. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    10. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)2 Joeson L.... Nielsen F.C. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Ensembl:ENSG00000224501

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hspa1a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ENSG00000224501 gene:
    Search GeneIP for patents involving ENSG00000224501

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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