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Aliases for ENSG00000207217 Gene

Subcategory (RNA class) for ENSG00000207217 Gene

snoRNA

Quality Score for this RNA gene is

3

Aliases for ENSG00000207217 Gene

  • Small Nucleolar RNA SNORA42/SNORA80 Family 5
  • SNORA42 5

External Ids for ENSG00000207217 Gene

ORGUL Members for ENSG00000207217 Gene

Previous GeneCards Identifiers for ENSG00000207217 Gene

  • GC07P006023
  • GC07P006056

Summaries for ENSG00000207217 Gene

GeneCards Summary for ENSG00000207217 Gene

ENSG00000207217 is an RNA Gene, and is affiliated with the snoRNA class.

fRNAdb sequence ontologies for ENSG00000207217 Gene - the ORGUL cluster for this gene includes several descriptions:

  • H_ACA_box_snoRNA: Members of the box H/ACA family contain an ACA triplet, exactly 3 nt upstream from the 3' end and an H-box in a hinge region that links two structurally similar functional domains of the molecule. Both boxes are important for snoRNA biosynthesis and function. A few box H/ACA snoRNAs are involved in rRNA processing; most others are known or predicted to participate in selection of uridine nucleosides in rRNA to be converted to pseudouridines. Site selection is mediated by direct base pairing of the snoRNA with rRNA through one or both targeting domains.

  • Small nucleolar RNA SNORA42/SNORA80 family: The members of this family belong to the H/ACA class of snoRNAs that guide the sites of modification of uridines to pseudouridines [1]. Human ACA42 (SNORA42) was cloned from HeLa cells by immunoprecipitation with anti-GAR1 antibody [1]. Its is predicted to guide the pseudouridylation of residues U109 and U572 of 18S rRNA [3]. ACA42 shares the same host gene with ACA26, ACA46, ACA50 [1]. This family also includes mammalian snoRNA ACA67 (SNORA80) which was identified by computational screening and its expression in mouse experimentally verified by Northern blot and primer extension analysis [2]. ACA67 is proposed to guide the pseudouridylation of the same 18S rRNA residues as ACA42 [3].

  • Small nucleolar RNA SNORA42/SNORA80 family: The members of this family belong to the H/ACA class of snoRNAs that guide the sites of modification of uridines to pseudouridines [1]. Human ACA42 (SNORA42) was cloned from HeLa cells by immunoprecipitation with anti-GAR1 antibody [1]. Its is predicted to guide the pseudouridylation of residues U109 and U572 of 18S rRNA [3]. ACA42 shares the same host gene with ACA26, ACA46, ACA50 [1]. This family also includes mammalian snoRNA ACA67 (SNORA80) which was identified by computational screening and its expression in mouse experimentally verified by Northern blot and primer extension analysis [2]. ACA67 is proposed to guide the pseudouridylation of the same 18S rRNA residues as ACA42 [3].

View fRNAdb secondary structures for ENSG00000207217

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for ENSG00000207217 Gene

Genomics for ENSG00000207217 Gene

Regulatory Elements for ENSG00000207217 Gene

Enhancers for ENSG00000207217 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G006198 0.9 ENCODE 11.1 +182.2 182161 0.9 ELF3 FOXA2 MLX ARID4B RARA FOS CREM THAP11 MIXL1 SP5 ENSG00000207217 EIF2AK1 GC07M006206 GC07M006175
GH07G006202 0.5 ENCODE 11.1 +185.4 185448 0.2 ZBTB33 PRDM10 ZNF18 ENSG00000207217 GC07M006206 GC07M006175
GH07G006338 0.4 ENCODE 11 +322.2 322248 1.4 PRDM10 RAC1 DAGLB EIF2AK1 ENSG00000207217 FAM220A GC07P006327
GH07G006014 1.3 Ensembl ENCODE 0.7 -0.5 -484 3.1 FOXA2 PKNOX1 ARNT SIN3A ARID4B DMAP1 ZNF766 FOS KLF13 JUNB EIF2AK1 PMS2 PMS2CL ENSG00000198580 CCZ1 RSPH10B ZDHHC4 ENSG00000207217 AIMP2
GH07G006019 1.1 ENCODE 0.7 +3.1 3144 1.0 HDGF HNRNPUL1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 ZNF207 EIF2AK1 RSPH10B CCZ1 ENSG00000207217 ANKRD61
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ENSG00000207217 on UCSC Golden Path with GeneCards custom track

Genomic Location for ENSG00000207217 Gene

Chromosome:
7
Start:
6,016,877 bp from pter
End:
6,017,011 bp from pter
Size:
135 bases
Orientation:
Plus strand

Genomic View for ENSG00000207217 Gene

Genes around ENSG00000207217 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENSG00000207217 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENSG00000207217 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

ORGUL Member Location for ENSG00000207217 Gene

ORGUL Member Location for ENSG00000207217 gene

No data available for RefSeq DNA sequence for ENSG00000207217 Gene

Proteins for ENSG00000207217 Gene

Post-translational modifications for ENSG00000207217 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ENSG00000207217 Gene

Domains & Families for ENSG00000207217 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ENSG00000207217 Gene

Function for ENSG00000207217 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENSG00000207217 Gene

Localization for ENSG00000207217 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ENSG00000207217 Gene

Pathways & Interactions for ENSG00000207217 Gene

SuperPathways for ENSG00000207217 Gene

No Data Available

Interacting Proteins for ENSG00000207217 Gene

Gene Ontology (GO) - Biological Process for ENSG00000207217 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ENSG00000207217 Gene

Drugs & Compounds for ENSG00000207217 Gene

No Compound Related Data Available

Transcripts for ENSG00000207217 Gene

fRNAdb Secondary structures for ENSG00000207217 Gene

  • RF00406;SNORA42;ADDF014847913.1/346-253
  • RF00406;SNORA42;AEKP01199961.1/111-1

mRNA/cDNA for ENSG00000207217 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ENSG00000207217 Gene

No ASD Table

Relevant External Links for ENSG00000207217 Gene

GeneLoc Exon Structure for
ENSG00000207217

Expression for ENSG00000207217 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ENSG00000207217 Gene

mRNA differential expression in normal tissues according to GTEx for ENSG00000207217 Gene

This gene is overexpressed in Brain - Cerebellum (x6.2) and Brain - Cerebellar Hemisphere (x5.8).
genes like me logo Genes that share expression patterns with ENSG00000207217: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENSG00000207217 Gene

Orthologs for ENSG00000207217 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ENSG00000207217 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORA42 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm26205 35
  • 83 (a)
ManyToMany
Gm23317 35
  • 56 (a)
ManyToMany
Gm24937 35
  • 54 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia SNORA42 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNORA42 35 35 35
  • 71 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia SNORA42 35
  • 66 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia SNORA42 35
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SNORA42 35
  • 68 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii SNORA42 35
  • 57 (a)
OneToMany
Species where no ortholog for ENSG00000207217 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ENSG00000207217 Gene

ENSEMBL:
Gene Tree for ENSG00000207217 (if available)
TreeFam:
Gene Tree for ENSG00000207217 (if available)

Paralogs for ENSG00000207217 Gene

No data available for Paralogs for ENSG00000207217 Gene

Variants for ENSG00000207217 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for ENSG00000207217 Gene

Disorders for ENSG00000207217 Gene

No disorders were found for ENSG00000207217 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for ENSG00000207217 Gene

Publications for ENSG00000207217 Gene

  1. A computational screen for mammalian pseudouridylation guide H/ACA RNAs. (PMID: 16373490) Schattner P. … Lowe T.M. (RNA 2006) 1
  2. Human box H/ACA pseudouridylation guide RNA machinery. (PMID: 15199136) Kiss A.M. … Kiss T. (Mol. Cell. Biol. 2004) 1

Products for ENSG00000207217 Gene

Sources for ENSG00000207217 Gene

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