ENSG00000206435 Gene
protein-coding GIFtS: 20
GCID: GC06Mo31229 (predicted)
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ENSG00000206435
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Aliases
for ENSG00000206435 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| D6S2043 | | MHC Class I Antigen Cw*173 | | HLA-JY33 | | MHC Class I Antigen Cw*43 | | HLAC3 | | MHC Class I Antigen Cw*53 | | MHC Class I Antigen Cw*153 | | MHC Class I Antigen Cw*83 |
Export aliases for ENSG00000206435 gene to outside databasesPrevious GC identifer: GC06Mc31374 |
Summaries
for ENSG00000206435 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/: 1C17_HUMAN, Q95604 (see all)Function: Involved in the presentation of foreign antigens to the immune system
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Genomic Views
for ENSG00000206435 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ENSG00000206435
Other transcription factors
Search SABiosciences Chromatin IP Primers for ENSG00000206435
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENSG00000206435 |
Genomic Location:
Chromosome:6
Ensembl cytogenetic band: HSCHR6_MHC_SSTOp21.33 GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06Mo31229: view genomic region
(about GC identifiers)
Start:
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31,229,147 bp from pter |
End:
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31,232,539 bp from pter |
Size:
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3,393 bases |
Orientation:
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minus strand |
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Proteins
for ENSG00000206435 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: 1C17_HUMAN, Q95604 (See
protein sequence)Recommended Name: HLA class I histocompatibility antigen, Cw-17 alpha chain precursor Size: 372 amino acids; 41238 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02864 O02958 Q29643 Q9MY30UniProtKB/Swiss-Prot: 1C15_HUMAN, Q07000 (See
protein sequence) Recommended Name: HLA class I histocompatibility antigen, Cw-15 alpha chain precursor Size: 366 amino acids; 40863 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O78165 Q29864 Q29991 Q31605 Q9BD28 Q9GJ33 Q9MY49UniProtKB/Swiss-Prot: 1C05_HUMAN, Q9TNN7 (See
protein sequence) Recommended Name: HLA class I histocompatibility antigen, Cw-5 alpha chain precursor Size: 366 amino acids; 40912 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O02866 O62888 Q9TPV8 Q9TPX2UniProtKB/Swiss-Prot: 1C04_HUMAN, P30504 (See
protein sequence) Recommended Name: HLA class I histocompatibility antigen, Cw-4 alpha chain precursor Size: 366 amino acids; 40995 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1protein (By similarity). Interacts with HTLV-1 p12I accessory protein
Subcellular location: Membrane; Single-pass type I membrane protein
2 PDB 3D structures from  and Proteopedia  for ENSG00000206435:1IM9 (3D)
1QQD (3D)
Secondary accessions: O78067 O78072 O78090 O78149 Q29921 Q9UM42UniProtKB/Swiss-Prot: 1C08_HUMAN, P30505 (See
protein sequence) Recommended Name: HLA class I histocompatibility antigen, Cw-8 alpha chain precursor Size: 366 amino acids; 40773 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1protein (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: P30506 P30507Explore the universe of human proteins at neXtProt for ENSG00000206435: NX_P30505
Post-translational modifications:
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets theprotein for rapid degradation via the ubiquitin system (By similarity)1
View neXtProt modification sites for NX_P30505
ENSG00000206435 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000372979 ENSP00000372975 ENSP00000403541 ENSP00000431141 ENSP00000383195 ENSP00000436842 ENSP00000411867 Reactome Protein details: P30505 Q95604 Q07000 Q9TNN7 P30504
Human Recombinant Protein Products for ENSG00000206435:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
ENSG00000206435 for ontologies About GeneDecksing
ENSG00000206435 Antibody Products:
Assay Products for ENSG00000206435: |
Protein
Domains /
Families
for ENSG00000206435 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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ENSG00000206435 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q95604Graphical View of Domain Structure for InterPro Entry Q07000Graphical View of Domain Structure for InterPro Entry Q9TNN7Graphical View of Domain Structure for InterPro Entry P30504Graphical View of Domain Structure for InterPro Entry P30505ProtoNet protein and cluster: Q95604 3 Blocks protein families: IPB001039 MHC class I signature IPB003597 Immunoglobulin C-type IPB010579 MHC_I
UniProtKB/Swiss-Prot: 1C17_HUMAN, Q95604Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1C15_HUMAN, Q07000Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1C05_HUMAN, Q9TNN7Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1C04_HUMAN, P30504Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 1C08_HUMAN, P30505Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain |
Function
for ENSG00000206435 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Molecular Function:
UniProtKB/ Summary: 1C17_HUMAN, Q95604 (see all)Function: Involved in the presentation of foreign antigens to the immune systemAnimal Models:
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Pathways & Interactions
for ENSG00000206435 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Pathway sources
See GeneCards unified pathways
Show all pathways
5/21 
Reactome Pathways for ENSG00000206435 (see all 21)
ENSG00000206435 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ENSG00000206435
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/164 Interacting proteins for ENSG00000206435 (P305042, 3 ENSP000003729754) via UniProtKB, MINT, STRING, and/or I2D (see all 164)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I |
-- | -- | | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
-- | -- | | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent |
-- | -- | | GO:0006955 | immune response |
-- | -- | | GO:0019221 | cytokine-mediated signaling pathway |
-- | -- |
ENSG00000206435 for ontologies About GeneDecksing
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Drugs & Compounds
for ENSG00000206435 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for ENSG00000206435
Search CenterWatch for drugs/clinical trials and news about ENSG00000206435 / 1C08 
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Transcripts
for ENSG00000206435 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
12 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000488240 ENST00000486729 ENST00000461470 ENST00000383487 ENST00000383483
ENST00000458668 ENST00000485321 ENST00000400341(uc011jhy.2 uc011jia.2 uc011jib.2)
ENST00000461937 ENST00000449884 ENST00000470176(uc011jig.1) ENST00000464623
GeneLoc Exon Structure
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Expression
for ENSG00000206435 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ENSG00000206435 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ENSG00000206435 Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for ENSG00000206435
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ENSG00000206435 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ENSG00000206435 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENSG00000206435 |
Orthologs
for ENSG00000206435 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ENSG00000206435 (if available)
TreeFam Gene Tree for ENSG00000206435 (if available) |
Paralogs
for ENSG00000206435 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ENSG00000206435 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: 1C08_HUMAN, P30505Polymorphism: The following alleles of Cw-17 are known: Cw*17:01, Cw*17:02 and Cw*17:03. The sequence shown is that ofCw*17:01Polymorphism: The following alleles of Cw-15 are known: Cw*15:02, Cw*15:03, Cw*15:04, Cw*15:05, Cw*15:10 and Cw*15:11.The sequence shown is that of Cw*15:02Polymorphism: The following alleles of Cw-5 are known: Cw*05:01 Cw*0502, Cw*05:03 and Cw*05:04. The sequence shown isthat of Cw*05:01Polymorphism: The following alleles of Cw-4 are known: Cw*04:01 Cw*04:03, Cw*04:04, Cw*04:05 and Cw*04:06. The sequenceshown is that of Cw*04:01Polymorphism: The following alleles of Cw-8 are known: Cw*08:01 (Cw8.1), Cw*08:02 (Cw8.2) and Cw*08:03. The sequenceshown is that of Cw*08:01
| SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for ENSG00000206435 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ENSG00000206435 for disorders About GeneDecksing
3  diseases for ENSG00000206435: About MalaCardst-cell leukemia immunodeficiency leukemia
Export disorders for ENSG00000206435 gene to outside databases
|
Publications
for ENSG00000206435 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ENSG00000206435 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ENSG00000206435) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Unusual HLA-B alleles in two tribes of Brazilian Indians. (PubMed id 1317015)2 Belich M.P.... Parham P. (1992)
- The molecular basis for reactivity of anti-Cw1 and anti-Cw3 alloantisera with HLA-B46 haplotypes. (PubMed id 1384166)2 Zemmour J.... Parham P. (1992)
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External Searches for ENSG00000206435 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ENSG00000206435 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ENSG00000206435 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ENSG00000206435 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ENSG00000206435 gene:
Search GeneIP for patents involving ENSG00000206435
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ENSG00000206435 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ENSG00000206435 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ENSG00000206435 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENSG00000206435 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ENSG00000206435 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENSG00000206435 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ENSG00000206435 |
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