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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ENSG00000206306 Gene

protein-coding   GIFtS: 17
GCID: GC06Mn32480          (predicted)

ENSG00000206306
 Explore 2 diseases affiliated with
ENSG00000206306 via
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Biological research products
for ENSG00000206306    

Aliases
for ENSG00000206306 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
DR-123     DRw113
DR-133     DRw83
DR-143     Clone P2-Beta-33
DR-53     MHC Class II Antigen DRB1*113
DR-83     MHC Class II Antigen DRB1*123
DR123     MHC Class II Antigen DRB1*133
DR133     MHC Class II Antigen DRB1*143
DR143     MHC Class II Antigen DRB1*33
DR53     MHC Class II Antigen DRB1*83
DR83     

External Ids:    Ensembl: ENSG000002063067   UniProtKB: Q5Y7A73   UniProtKB: Q9GIY33   UniProtKB: P200393   UniProtKB: Q95IE33   
UniProtKB: P019123   UniProtKB: Q301343   

Export aliases for ENSG00000206306 gene to outside databases

Previous GC identifer: GC06Mf32625


Summaries
for ENSG00000206306 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/: 2B1D_HUMAN, Q5Y7A7 (see all)
Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and
presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides
of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins
that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous
antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and
for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their
way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal
compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a
source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition
to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74
and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an
antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the
ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen
processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a
small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM
via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules
until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported
to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by
HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the
regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and
efficient peptide loading




Genomic Views
for ENSG00000206306 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ENSG00000206306
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ENSG00000206306

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENSG00000206306


Genomic Location:
Chromosome:6   

Ensembl cytogenetic band:  HSCHR6_MHC_QBLp21.32   

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06Mn32480:  view genomic region     (about GC identifiers)

Start:
 32,481,203 bp from pter      End:
 32,511,820 bp from pter
Size:
 30,618 bases      Orientation:
 minus strand

Proteins
for ENSG00000206306 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: 2B1D_HUMAN, Q5Y7A7 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen, DRB1-13 beta chain precursor  
Size: 266 amino acids; 30008 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Sequence caution: Sequence=CAB40418.1; Type=Erroneous gene model prediction;
Secondary accessions: A0MWF2 A2ICT1 A4ZXA5 A4ZXA6 A7UHG2 A7X5K7 A8YQE9 B0BK85 B3VTQ3 B5A8Y2 B5A8Y3
B5B9V6 B5QSK8 C0LAB5 O02930 O62889 O78047 P79545 Q14280 Q14QT2 Q19K86 Q1G0Z9 Q1KLJ6 Q29673 Q29720
Q29722 Q29806 Q29833 Q29874 Q29886 Q2MF40 Q2YHQ2 Q30112 Q3LA93 Q3LA94 Q3LA95 Q3LA96 Q3LA97 Q3LA98
Q3LA99 Q3LAA0 Q3LAA1 Q3LAA2 Q3MQ60 Q53IG1 Q56FP2 Q56FP3 Q58F52 Q5K3W2 Q5UBA2 Q5W3L4 Q6REE2 Q6U387
Q701T1 Q70Q85 Q768U2 Q7YP03 Q7YQ26 Q7YQA3 Q860E5 Q860H8 Q860Z3 Q861G6 Q861H0 Q861H4 Q8HWQ6 Q8WMA0
Q95389 Q95HL1 Q96HZ9 Q9BCP5 Q9BD21 Q9GIP3 Q9GJ25 Q9GJ60 Q9GJF8 Q9GJF9 Q9GJG0 Q9MY45 Q9MY56 Q9TPW3
Q9TPW9 Q9TPX4 Q9UBY1 Q9UIN0 Q9XRX1 Q9Y453

UniProtKB/Swiss-Prot: 2B1E_HUMAN, Q9GIY3 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-14 beta chain precursor  
Size: 266 amino acids; 30139 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Sequence caution: Sequence=CAB45249.1; Type=Erroneous gene model prediction;
Secondary accessions: A0N0W1 A2TGX3 A4ZY86 A5H000 A5HKN8 A7DZP9 A7X5B1 A7X5B7 A7X5E0 A7X5E6 A7X5H8
A9JPG0 B1GWE7 B2CR03 B2LVF9 B2NJ29 B2ZCY1 B3VTP8 B5B8U0 B5B9V5 B5LZ25 B6VEL9 B9VRA4 B9X248 O02876
O46793 O77969 O78210 Q0PQ39 Q155F7 Q1AP33 Q1JRP3 Q27PR6 Q27PR7 Q29734 Q29770 Q29772 Q29800 Q2A120
Q2HZE5 Q2LE76 Q2MJA6 Q2VQU1 Q307W5 Q31636 Q3LA87 Q3LA88 Q3LA89 Q3LA90 Q3LA91 Q3LA92 Q3T919 Q4PRC3
Q4PRC5 Q4VZY7 Q56FP1 Q5BM92 Q5U9W6 Q683P7 Q70GL2 Q7YNY9 Q7YQA5 Q860D8 Q860D9 Q860S0 Q861H5 Q861H7
Q8MH59 Q8MH60 Q8WLU3 Q95348 Q95HK1 Q95HL0 Q95IG2 Q9GIL5 Q9GIL6 Q9GIY0 Q9GIY1 Q9GIY2 Q9GJ56 Q9GJ57
Q9GJ58 Q9TPB6 Q9TPW1 Q9XRY4 Q9Y4H7

UniProtKB/Swiss-Prot: 2B1B_HUMAN, P20039 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-11 beta chain precursor  
Size: 266 amino acids; 30160 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Secondary accessions: Q30006 Q9GIX8

UniProtKB/Swiss-Prot: 2B1C_HUMAN, Q95IE3 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-12 beta chain precursor  
Size: 266 amino acids; 29878 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Secondary accessions: A7LA26 B0LUZ6 B6VCX2 B7UDB2 O19585 Q19AF2 Q29771 Q2L9H4 Q2MZ92 Q5EER6 Q5NDB9
Q5UT58 Q5Y7G0 Q768U4 Q7YP04 Q861H8 Q95IT6 Q9BD40

UniProtKB/Swiss-Prot: 2B13_HUMAN, P01912 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-3 chain precursor  
Size: 266 amino acids; 30120 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
1 PDB 3D structure from and Proteopedia for ENSG00000206306:
1A6A (3D)    

UniProtKB/Swiss-Prot: 2B18_HUMAN, Q30134 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-8 beta chain precursor  
Size: 266 amino acids; 30004 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Secondary accessions: O19718 O19788 Q29968 Q30108 Q30115 Q9BCP0 Q9BCP1 Q9BCP2 Q9BD33 Q9TQ37 Q9UIM9

Explore the universe of human proteins at neXtProt for ENSG00000206306: NX_Q30134

Post-translational modifications:

  • Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC
    • class II (Probable)1
  • View neXtProt modification sites for NX_Q30134

    • ENSG00000206306 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).


    ENSEMBL proteins: 
     ENSP00000331343   ENSP00000412168  
    Reactome Protein details: Q95IE3 P01912 Q5Y7A7 Q30134 Q9GIY3 P20039
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for ENSG00000206306 
    GenScript Custom Purified and Recombinant Proteins Services for ENSG00000206306
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane ----
    GO:0005789endoplasmic reticulum membrane ----
    GO:0005794Golgi apparatus ----
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane ----


    ENSG00000206306 for ontologies           About GeneDecksing



    ENSG00000206306 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ENSG00000206306
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ENSG00000206306 
    GenScript Custom Superior Antibodies Services for ENSG00000206306
    Search for Antibodies for ENSG00000206306 at Abcam  
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for ENSG00000206306

    Assay Products for ENSG00000206306: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ENSG00000206306
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for ENSG00000206306 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ENSG00000206306 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR007110 Ig-like_dom
     IPR013783 Ig-like_fold
     IPR014745 MHC_II_a/b_N
     IPR003006 Ig/MHC_CS
     IPR011162 MHC_I/II-like_Ag-recog

    Graphical View of Domain Structure for InterPro Entry Q5Y7A7
    Graphical View of Domain Structure for InterPro Entry Q9GIY3
    Graphical View of Domain Structure for InterPro Entry P20039
    Graphical View of Domain Structure for InterPro Entry Q95IE3
    Graphical View of Domain Structure for InterPro Entry P01912
    Graphical View of Domain Structure for InterPro Entry Q30134

    ProtoNet protein and cluster: Q5Y7A7

    2 Blocks protein families:
    IPB000353 Class II histocompatibility antigen
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: 2B1D_HUMAN, Q5Y7A7
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1E_HUMAN, Q9GIY3
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1B_HUMAN, P20039
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1C_HUMAN, Q95IE3
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B13_HUMAN, P01912
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B18_HUMAN, Q30134
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Function
    for ENSG00000206306 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
    UniProtKB/: 2B1D_HUMAN, Q5Y7A7 (see all)
    Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and
    presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides
    of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins
    that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous
    antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and
    for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their
    way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal
    compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a
    source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition
    to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74
    and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an
    antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the
    ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen
    processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a
    small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM
    via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules
    until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported
    to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by
    HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the
    regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and
    efficient peptide loading

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ENSG00000206306
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ENSG00000206306
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    Inhib. RNA
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ENSG00000206306

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENSG00000206306
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    Cell Line
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    Search LifeMap BioReagents cell lines for ENSG00000206306

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENSG00000206306

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032395MHC class II receptor activity ----


    ENSG00000206306 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ENSG00000206306 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/20        Reactome Pathways for ENSG00000206306 (see all 20)
        Internalization of MHC II:Ii clathrin coated vesicle
    Costimulation by the CD28 family
    Transport of MHC II:Ii complex along Golgi to TGN
    Transport of MHC II:Ii complex to plasma membrane
    Transport of antigen loaded MHC II molecules to surface



    ENSG00000206306 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ENSG00000206306

    2 Interacting proteins for ENSG00000206306 (P019122, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-DRAP019032MINT-24910
    --uniprotid: Q9GIY33I2D: score= 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002381immunoglobulin production involved in immunoglobulin mediated immune response ----
    GO:0002455humoral immune response mediated by circulating immunoglobulin ----
    GO:0002504antigen processing and presentation of peptide or polysaccharide antigen via MHC class II ----
    GO:0019221cytokine-mediated signaling pathway ----
    GO:0031295T cell costimulation ----


    ENSG00000206306 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ENSG00000206306 gene

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    Transcripts
    for ENSG00000206306 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328980(uc021zuy.1 uc011ixc.1 uc021zuz.1 uc011ixe.1)
    ENST00000415796

    miRNA
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    GeneLoc Exon Structure


    Expression
    for ENSG00000206306 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ENSG00000206306 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ENSG00000206306 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for ENSG00000206306
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    Orthologs
    for ENSG00000206306 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    		   --

    ENSEMBL Gene Tree for ENSG00000206306 (if available)
    TreeFam Gene Tree for ENSG00000206306 (if available) 

    Paralogs
    for ENSG00000206306 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ENSG00000206306 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: 2B18_HUMAN, Q30134
    Polymorphism: The following alleles of DRB1-13 are known: DRB1*13:01, DRB1*13:02, DRB1*13:03, DRB1*13:04, DRB1*13:05,
    DRB1*13:06, DRB1*13:07, DRB1*13:08, DRB1*13:09, DRB1*13:10, DRB1*13:11, DRB1*13:12, DRB1*13:13, DRB1*13:14,
    DRB1*13:15, DRB1*13:16, DRB1*13:17, DRB1*13:18, DRB1*13:19, DRB1*13:20, DRB1*13:21, DRB1*13:22, DRB1*13:23,
    DRB1*13:24, DRB1*13:25, DRB1*13:26, DRB1*13:27, DRB1*13:28, DRB1*13:29, DRB1*13:30, DRB1*13:31, DRB1*13:32,
    DRB1*13:33, DRB1*13:34, DRB1*13:35, DRB1*13:36, DRB1*13:37, DRB1*13:38, DRB1*13:39, DRB1*13:40, DRB1*13:41,
    DRB1*13:42, DRB1*13:43, DRB1*13:44, DRB1*13:45, DRB1*13:46, DRB1*13:47, DRB1*13:48, DRB1*13:49, DRB1*13:50,
    DRB1*13:51, DRB1*13:52, DRB1*13:53, DRB1*13:54, DRB1*13:55, DRB1*13:56, DRB1*13:57, DRB1*13:58, DRB1*13:59,
    DRB1*13:60, DRB1*13:61, DRB1*13:62, DRB1*13:63, DRB1*13:64, DRB1*13:65, DRB1*13:66, DRB1*13:67, DRB1*13:68,
    DRB1*13:69, DRB1*13:70, DRB1*13:71, DRB1*13:72, DRB1*13:73, DRB1*13:74, DRB1*13:75, DRB1*13:76, DRB1*13:77,
    DRB1*13:78, DRB1*13:79, DRB1*13:80, DRB1*13:81, DRB1*13:82, DRB1*13:83, DRB1*13:84, DRB1*13:85, DRB1*13:86, DRB1*13:87
    and DRB1*13:88. The sequence shown is that of DRB1*13:01
    Polymorphism: The following alleles of DRB1-14 are known: DRB1*14:01, DRB1*14:02, DRB1*14:03, DRB1*14:04, DRB1*14:05,
    DRB1*14:06, DRB1*14:07, DRB1*14:08, DRB1*14:09, DRB1*14:10, DRB1*14:11, DRB1*14:12, DRB1*14:13, DRB1*14:14,
    DRB1*14:15, DRB1*14:16, DRB1*14:17, DRB1*14:18, DRB1*14:19, DRB1*14:20, DRB1*14:21, DRB1*14:22, DRB1*14:23,
    DRB1*14:24, DRB1*14:25, DRB1*14:26, DRB1*14:27, DRB1*14:28, DRB1*14:29, DRB1*14:30, DRB1*14:31, DRB1*14:32,
    DRB1*14:33, DRB1*14:34, DRB1*14:35, DRB1*14:36, DRB1*14:37, DRB1*14:38, DRB1*14:39, DRB1*14:40, DRB1*14:41,
    DRB1*14:42, DRB1*14:43, DRB1*14:44, DRB1*14:45, DRB1*14:46, DRB1*14:47, DRB1*14:48, DRB1*14:49, DRB1*14:50,
    DRB1*14:51, DRB1*14:52, DRB1*14:53, DRB1*14:54, DRB1*14:55, DRB1*14:56, DRB1*14:57, DRB1*14:58, DRB1*14:59,
    DRB1*14:60, DRB1*14:61, DRB1*14:62, DRB1*14:63, DRB1*14:64, DRB1*14:65, DRB1*14:67, DRB1*14:68, DRB1*14:69,
    DRB1*14:70, DRB1*14:71, DRB1*14:72, DRB1*14:73, DRB1*14:74, DRB1*14:75, DRB1*14:76, DRB1*14:77, DRB1*14:78,
    DRB1*14:79, DRB1*14:80, DRB1*14:81, DRB1*14:82, DRB1*14:83, DRB1*14:84 and DRB1*14:85. The sequence shown is that of
    DRB1*14:01
    Polymorphism: The following alleles of DRB1-11 are known: DRB1*11:01, DRB1*11:03, DRB1*11:04, DRB1*11:05, DRB1*11:06,
    DRB1*11:07, DRB1*11:08, DRB1*11:09, DRB1*11:10, DRB1*11:11, DRB1*11:12, DRB1*11:13, DRB1*11:14, DRB1*11:15,
    DRB1*11:16, DRB1*11:17, DRB1*11:18, DRB1*11:19, DRB1*11:20, DRB1*11:21, DRB1*11:22, DRB1*11:23, DRB1*11:24,
    DRB1*11:25, DRB1*11:26, DRB1*11:27, DRB1*11:28, DRB1*11:29, DRB1*11:30, DRB1*11:31, DRB1*11:32, DRB1*11:33,
    DRB1*11:34, DRB1*11:35, DRB1*11:36, DRB1*11:37, DRB1*11:38, DRB1*11:39, DRB1*11:40, DRB1*11:41, DRB1*11:42,
    DRB1*11:43, DRB1*11:44, DRB1*11:45, DRB1*11:46, DRB1*11:47, DRB1*11:48, DRB1*11:49, DRB1*11:50, DRB1*11:51,
    DRB1*11:52, DRB1*11:53, DRB1*11:54, DRB1*11:55, DRB1*11:56, DRB1*11:57, DRB1*11:58, DRB1*11:59, DRB1*11:60,
    DRB1*11:61, DRB1*11:62, DRB1*11:63, DRB1*11:64, DRB1*11:65, DRB1*11:66, DRB1*11:67, DRB1*11:68, DRB1*11:69, DRB1*11:70
    and DRB1*11:72. The sequence shown is that of DRB1*11:01
    Polymorphism: Allele DRB1*11:01 is associated with self-limiting hepatitis C virus (HCV) infections [MIM:609532]
    Polymorphism: The following alleles of DRB1-12 are known: DRB1*12:01, DRB1*12:02, DRB1*12:03, DRB1*12:04, DRB1*12:05,
    DRB1*12:06, DRB1*12:07, DRB1*12:08, DRB1*12:09, DRB1*12:10, DRB1*12:11, DRB1*12:12, DRB1*12:13, DRB1*12:14,
    DRB1*12:15, DRB1*12:16, DRB1*12:17, DRB1*12:18 and DRB1*12:19. The sequence shown is that of DRB1*12:01
    Polymorphism: The following alleles of DRB1-3 are known: DRB1*03:01; DRB1*03:02; DRB1*03:03; DRB1*03:04; DRB1*03:05;
    DRB1*03:06; DRB1*03:07; DRB1*03:08; DRB1*03:09; DRB1*03:10; DRB1*03:11; DRB1*03:12; DRB1*03:13; DRB1*03:14;
    DRB1*03:15; DRB1*03:16; DRB1*03:17; DRB1*03:18; DRB1*03:19; DRB1*03:20; DRB1*03:21; DRB1*03:22; DRB1*03:23;
    DRB1*03:24; DRB1*03:25; DRB1*03:26; DRB1*03:27; DRB1*03:28; DRB1*03:29; DRB1*03:30; DRB1*03:31; DRB1*03:32;
    DRB1*03:33; DRB1*03:34; DRB1*03:35; DRB1*03:36; DRB1*03:37; DRB1*03:38; DRB1*03:39; DRB1*03:40 and DRB1*03:41. The
    sequence shown is that of DRB1*03:01
    Polymorphism: The following alleles of DRB1-8 are known: DRB1*08:01 (Dw8.1), DRB1*08:02 (Dw8.2; DRB1L), DRB1*08:03
    (Dw8.3); DRB1*08:04; DRB1*08:05, DRB1*08:06, DRB1*08:07, DRB1*08:08, DRB1*08:09, DRB1*08:10, DRB1*08:11, DRB1*08:12,
    DRB1*08:13, DRB1*08:14, DRB1*08:15, DRB1*08:16, DRB1*08:17, DRB1*08:18, DRB1*08:19, DRB1*08:20, DRB1*08:21,
    DRB1*08:22, DRB1*08:23, DRB1*08:24, DRB1*08:25, DRB1*08:26, DRB1*08:27, DRB1*08:28, DRB1*08:29, DRB1*08:30,
    DRB1*08:31, DRB1*08:32, DRB1*08:33, DRB1*08:34, DRB1*08:35 and DRB1*08:36. The sequence shown is that of DRB1*08:01

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    Disorders / Diseases
    for ENSG00000206306 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ENSG00000206306 for disorders           About GeneDecksing

    2 diseases for ENSG00000206306:    About MalaCards
    hepatitis c    hepatitis


    Export disorders for ENSG00000206306 gene to outside databases

    Publications
    for ENSG00000206306 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ENSG00000206306 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ENSG00000206306)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract. (PubMed id 19533806)2 Beswick E.J. and Reyes V.E. (2009)
    2. MHC class II transport at a glance. (PubMed id 19092054)2 Berger A.C. and Roche P.A. (2009)
    3. MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. (PubMed id 18305173)2 De Gassart A....Gatti E. (2008)
    4. MHC class II molecules on the move for successful antigen presentation. (PubMed id 18046453)2 Rocha N. and Neefjes J. (2008)
    5. Autophagy in MHC class II presentation: sampling from within. (PubMed id 17241953)2 Menendez-Benito V. and Neefjes J. (2007)
    6. Presentation of antigens by MHC class II molecules: getting the most out of them. (PubMed id 11684289)2 Villadangos J.A. (2001)
    7. Invariant chain structure and MHC class II function. (PubMed id 8598037)2 Cresswell P. (1996)
    8. Analysis of HLA class II haplotypes in the Cayapa Indians of Ecuador: a novel DRB1 allele reveals evidence for convergent evolution and balancing selection at position 86. (PubMed id 8023844)2 Titus-Trachtenberg E.A.... Erlich H.A. (1994)
    9. The different level of expression of HLA-DRB1 and -DRB3 genes is controlled by conserved isotypic differences in promoter sequence. (PubMed id 8106268)2 Emery P.... Reith W. (1993)
    10. A distinct HLA-DRw8 haplotype characterizes patients with juvenile rheumatoid arthritis. (PubMed id 1979063)2 Van Kerckhove C.... Glass D.N. (1990)

    External Searches for ENSG00000206306 gene

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    Genome Databases showing ENSG00000206306 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Ensembl:ENSG00000206306

    Other Databases showing ENSG00000206306 gene

    (According to HUGE)
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    Specialized Databases showing ENSG00000206306 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    Intellectual Property
    for ENSG00000206306 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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