Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ENSG00000188223 Gene

Aliases for ENSG00000188223 Gene

  • AD000671.1 5

External Ids for ENSG00000188223 Gene

Previous GeneCards Identifiers for ENSG00000188223 Gene

  • GC19P040937
  • GC19P036237
  • GC19P035775
  • GC19P035825
  • GC19P035854
  • GC19P036009
  • GC19P036172
  • GC19P036248

Summaries for ENSG00000188223 Gene

GeneCards Summary for ENSG00000188223 Gene

ENSG00000188223 is a Protein Coding gene. Diseases associated with ENSG00000188223 include Anal Canal Squamous Cell Carcinoma and Dowling-Degos Disease. An important paralog of this gene is PSENEN.

Additional gene information for ENSG00000188223 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENSG00000188223 Gene

Genomics for ENSG00000188223 Gene

Regulatory Elements for ENSG00000188223 Gene

Enhancers for ENSG00000188223 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H035743 1.1 ENCODE 0.7 +0.9 885 5.9 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF302 U2AF1L4 PROSER3 TMEM147-AS1 KMT2B ZNF567 ZNF566 RBM42 HAUS5 ENSG00000267049 ZNF792
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ENSG00000188223 on UCSC Golden Path with GeneCards custom track

Promoters for ENSG00000188223 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109059 -78 1601 HDGF ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF207 ZNF143 SP3 ZHX2

Genomic Locations for ENSG00000188223 Gene

Genomic Locations for ENSG00000188223 Gene
8,842 bases
Plus strand

Genomic View for ENSG00000188223 Gene

Genes around ENSG00000188223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENSG00000188223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENSG00000188223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for ENSG00000188223 Gene

Proteins for ENSG00000188223 Gene

  • Protein details for ENSG00000188223 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein
    Protein Accession:

    Protein attributes for ENSG00000188223 Gene

    55 amino acids
    Molecular mass:
    6639 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ENSG00000188223 Gene

Post-translational modifications for ENSG00000188223 Gene

No Post-translational modifications

Other Protein References for ENSG00000188223 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ENSG00000188223 Gene

Domains & Families for ENSG00000188223 Gene

Protein Domains for ENSG00000188223 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ENSG00000188223: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ENSG00000188223 Gene

Function for ENSG00000188223 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENSG00000188223 Gene

Localization for ENSG00000188223 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENSG00000188223 gene
Compartment Confidence
nucleus 3
plasma membrane 2
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ENSG00000188223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070765 gamma-secretase complex IBA --
genes like me logo Genes that share ontologies with ENSG00000188223: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ENSG00000188223 Gene

Pathways & Interactions for ENSG00000188223 Gene

SuperPathways for ENSG00000188223 Gene

No Data Available

Interacting Proteins for ENSG00000188223 Gene

Gene Ontology (GO) - Biological Process for ENSG00000188223 Gene


No data available for Pathways by source and SIGNOR curated interactions for ENSG00000188223 Gene

Drugs & Compounds for ENSG00000188223 Gene

No Compound Related Data Available

Transcripts for ENSG00000188223 Gene

mRNA/cDNA for ENSG00000188223 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ENSG00000188223 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a ·
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: - -
SP8: - -
SP9: - -

ExUns: 12b ^ 13 ^ 14

Relevant External Links for ENSG00000188223 Gene

GeneLoc Exon Structure for

Expression for ENSG00000188223 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENSG00000188223 Gene

Orthologs for ENSG00000188223 Gene

This gene was present in the common ancestor of animals.

Orthologs for ENSG00000188223 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PSENEN 34
  • 54 (a)
(Canis familiaris)
Mammalia PSENEN 34
  • 54 (a)
(Bos Taurus)
Mammalia PSENEN 34
  • 53 (a)
(Mus musculus)
Mammalia Psenen 34
  • 53 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
(Danio rerio)
Actinopterygii psenen 34
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta pen-2 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea pen-2 34
  • 23 (a)
Species where no ortholog for ENSG00000188223 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ENSG00000188223 Gene

Gene Tree for ENSG00000188223 (if available)
Gene Tree for ENSG00000188223 (if available)

Paralogs for ENSG00000188223 Gene

Paralogs for ENSG00000188223 Gene

genes like me logo Genes that share paralogs with ENSG00000188223: view

Variants for ENSG00000188223 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for ENSG00000188223 Gene

Disorders for ENSG00000188223 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ENSG00000188223 Gene - From: DISEASES

Disorder Aliases PubMed IDs
anal canal squamous cell carcinoma
  • squamous cell carcinoma of the anal canal
dowling-degos disease
  • dark dot disease
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ENSG00000188223: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for ENSG00000188223 Gene

Publications for ENSG00000188223 Gene

No publications were found for ENSG00000188223 Gene.

Products for ENSG00000188223 Gene

Sources for ENSG00000188223 Gene

Loading form....