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ENSG00000137345 Gene

protein-coding   GIFtS: 16
GCID: GC06Pn29624          (predicted)

ENSG00000137345


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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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External Ids:    Ensembl: ENSG000001373457   UniProtKB: Q166533   

Export aliases for ENSG00000137345 gene to outside databases

Previous GC identifer: GC06Pf29767


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ENSG00000137345 Gene:
ENSG00000137345 is a protein-coding gene.

UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653
Function: Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be
involved in completion and/or maintenance of the myelin sheath and in cell-cell communication




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for ENSG00000137345
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ENSG00000137345

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ENSG00000137345


Genomic Location:
Chromosome:6   

Ensembl cytogenetic band:  HSCHR6_MHC_QBLp22.1   

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06Pn29624:       (about GC identifiers)

Start:
29,624,680 bp from start of contig ALT_REF_LOCI_6      End:
29,640,072 bp from start of contig ALT_REF_LOCI_6
Size:
15,393 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653 (See protein sequence)
Recommended Name: Myelin-oligodendrocyte glycoprotein precursor  
Size: 247 amino acids; 28193 Da
Subunit: Homodimer (By similarity). May form heterodimers between the different isoforms
Caution: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG)
1 PDB 3D structure from and Proteopedia for ENSG00000137345:
1Q70 (3D)    
Secondary accessions: A6NDR4 A6NNJ9 A8MY31 B0UZR9 E9PGF0 F8W9D5 O00713 O00714 O00715 Q13054
Q13055 Q14855 Q29ZN8 Q56UY0 Q5JNX7 Q5JNY1 Q5JNY2 Q5JNY4 Q5SSB5 Q5SSB6 Q5STL9 Q5STM0 Q5STM1
Q5STM5 Q5SUK7 Q5SUK8 Q5SUK9 Q5SUL0 Q5SUL1 Q92891 Q92892 Q92893 Q92894 Q92895 Q93053 Q96KU9
Q96KV0 Q96KV1 Q99605
Alternative splicing: 12 isoforms:  Q16653-1   Q16653-2   Q16653-3   Q16653-4   Q16653-5   Q16653-6   Q16653-7   Q16653-8   
Q16653-9   Q16653-10   Q16653-11   Q16653-12   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ENSG00000137345: NX_Q16653

Explore proteomics data for ENSG00000137345 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ENSG00000137345 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000373126   ENSP00000259891   ENSP00000373127   ENSP00000352534   ENSP00000383526  
     ENSP00000394156   ENSP00000414146   ENSP00000383528   ENSP00000383525   ENSP00000449845  
     ENSP00000449213   ENSP00000448441   ENSP00000446956  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR016663 Myelin-oligodendrocyte_glycop
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q16653

    ProtoNet protein and cluster: Q16653

    1 Blocks protein domain: IPB003596 Immunoglobulin V-type

    UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with ENSG00000137345           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOG_HUMAN, Q16653
    Function: Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be
    involved in completion and/or maintenance of the myelin sheath and in cell-cell communication

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ENSG00000137345           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MOG_HUMAN, Q16653: Isoform 1: Cell membrane; Multi-pass membrane protein (Potential)
    MOG_HUMAN, Q16653: Isoform 5: Cell membrane; Multi-pass membrane protein (Potential)
    MOG_HUMAN, Q16653: Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential)
    MOG_HUMAN, Q16653: Isoform 3: Cell membrane; Single-pass type I membrane protein (Potential)
    MOG_HUMAN, Q16653: Isoform 4: Cell membrane; Single-pass type I membrane protein (Potential)
    MOG_HUMAN, Q16653: Isoform 6: Cell membrane; Single-pass type I membrane protein (Potential)
    MOG_HUMAN, Q16653: Isoform 7: Cell membrane; Single-pass type I membrane protein (Potential)
    MOG_HUMAN, Q16653: Isoform 8: Cell membrane; Single-pass type I membrane protein (Potential)
    MOG_HUMAN, Q16653: Isoform 9: Cell membrane; Single-pass type I membrane protein (Potential)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with ENSG00000137345           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ENSG00000137345
    Interactions:

        Search GeneGlobe Interaction Network for ENSG00000137345

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for ENSG00000137345 (Q166533 ENSP000002598914) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRNPP041563I2D: score=3 
    GRB2P629933I2D: score=2 
    OTUD4Q018043I2D: score=2 
    DLG4P783523I2D: score=1 
    GRIN2BQ132243I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion ----
    GO:0007417central nervous system development ----
    GO:0034126positive regulation of MyD88-dependent toll-like receptor signaling pathway ----

    Find genes that share ontologies with ENSG00000137345           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ENSG00000137345 (MOG)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000383630 ENST00000492471 ENST00000259891(uc011iez.2) ENST00000465504
    ENST00000383631 ENST00000359539 ENST00000400688 ENST00000415631 ENST00000442444
    ENST00000400691 ENST00000400687 ENST00000461235 ENST00000484234 ENST00000548951(uc011ifm.2)
    ENST00000547083(uc011ife.2 uc011ifd.2 uc011ifi.2 uc011ifk.2 uc011ifj.2 uc011ifl.2)
    ENST00000552767 ENST00000549967(uc011iew.2 uc011iex.2 uc011iey.2 uc011ifc.2 uc011ifb.2 uc011ifg.2 uc011ifh.2)

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    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ENSG00000137345    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
    SP1:              -                           
    SP2:                                          
    SP3:                                          



    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    ENSG00000137345 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ENSG00000137345 Protein Expression

    UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653
    Tissue specificity: Found exclusively in the CNS, where it is localized on the surface of myelin and
    oligodendrocyte cytoplasmic membranes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for ENSG00000137345 (if available)
    TreeFam Gene Tree for ENSG00000137345 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653
  • Narcolepsy 7 (NRCLP7) [MIM:614250]: Neurological disabling sleep disorder, characterized by excessive
    daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy,
    hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions,
    which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a
    sporadically occurring disorder but familial clustering has been observed. Note=The disease is caused by
    mutations affecting the gene represented in this entry


  • Find genes that share disorders with ENSG00000137345           About GenesLikeMe


    Export disorders for ENSG00000137345 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ENSG00000137345 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ENSG00000137345)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A missense mutation in myelin oligodendrocyte glycoprotein as a cause of familial narcolepsy with cataplexy. (PubMed id 21907016)2 Hor H....Peraita-Adrados R. (Am. J. Hum. Genet. 2011)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)
    4. A conformational study of the human and rat encephalitogenic myelin oligodendrocyte glycoprotein peptides 35-55. (PubMed id 9210466)2 Albouz-Abo S.... von Itzstein M. (Eur. J. Biochem. 1997)
    5. Myelin/oligodendrocyte glycoprotein is alternatively spliced in humans but not mice. (PubMed id 8915905)2 Ballenthin P.A. and Gardinier M.V. (J. Neurosci. Res. 1996)
    6. The human myelin oligodendrocyte glycoprotein (MOG) gene: complete nucleotide sequence and structural characterization. (PubMed id 8530032)2 Roth M.-P.... Coppin H. (Genomics 1995)
    7. Structure of the human myelin/oligodendrocyte glycoprotein gene and multiple alternative spliced isoforms. (PubMed id 8666381)2 Pham-Dinh D.... Dautigny A. (Genomics 1995)
    8. Characterization of cDNA and genomic clones encoding human myelin oligodendrocyte glycoprotein. (PubMed id 7790876)2 Hilton A.A.... Bernard C.C.A. (J. Neurochem. 1995)
    9. Characterization and expression of the cDNA coding for the human myelin/oligodendrocyte glycoprotein. (PubMed id 7964757)2 Pham-Dinh D.... Dautigny A. (J. Neurochem. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Ensembl:ENSG00000137345

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    Wikipedia http://en.wikipedia.org/wiki/Myelin_oligodendrocyte_glycoprotein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ENSG00000137345 gene:
    Search GeneIP for patents involving ENSG00000137345

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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