Aliases for ENSA Gene
Aliases for ENSA Gene
External Ids for ENSA Gene
- HGNC: 3360
- Entrez Gene: 2029
- Ensembl: ENSG00000143420
- OMIM: 603061
- UniProtKB: O43768
Previous GeneCards Identifiers for ENSA Gene
- GC01M148437
- GC01M146342
- GC01M147368
- GC01M147811
- GC01M147408
- GC01M148840
- GC01M148861
- GC01M150574
- GC01M121972
- GC01M150577
- GC01M150595
- GC01M150601
- GC01M150606
- GC01M150611
- GC01M150614
Summaries for ENSA Gene
-
The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
GeneCards Summary for ENSA Gene
ENSA (Endosulfine Alpha) is a Protein Coding gene. Diseases associated with ENSA include Diabetes Mellitus, Insulin-Dependent, 11. Among its related pathways are Mitotic Prophase and Cell Cycle, Mitotic. GO annotations related to this gene include receptor binding. An important paralog of this gene is ARPP19.
UniProtKB/Swiss-Prot for ENSA Gene
-
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENSA Gene
Genomics for ENSA Gene
Regulatory Elements for ENSA Gene
Enhancers for ENSA Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ENSA on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ENSA gene promoter:
Regulatory Element Products
Genomic Location for ENSA Gene
- Chromosome:
- 1
- Start:
- 150,600,851 bp from pter
- End:
- 150,629,622 bp from pter
- Size:
- 28,772 bases
- Orientation:
- Minus strand
Genomic View for ENSA Gene
Genes around ENSA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
ENSA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ENSA Gene
Proteins for ENSA Gene
-
Protein details for ENSA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43768-ENSA_HUMAN
- Recommended name:
- Alpha-endosulfine
- Protein Accession:
- O43768
- A8K1Z9
- E9PB69
- Q5T5H2
- Q68D48
- Q6FHW0
- Q6IAM4
- Q6NUL2
- Q6VUC6
- Q6VUC7
- Q6VUC8
- Q6VUC9
- Q6VUD0
- Q6VUD1
- Q9NRZ0
Protein attributes for ENSA Gene
- Size:
- 121 amino acids
- Molecular mass:
- 13389 Da
- Quaternary structure:
-
- Interacts (when phosphorylated at Ser-67) with PPP2R2D (By similarity). Interacts with ABCC8. Interacts with SNCA; interaction is disrupted when phosphorylated at Ser-109.
Protein Expression for ENSA Gene
Post-translational modifications for ENSA Gene
- Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ENSA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for ENSA (ENSA)
-
Custom Antibody ServicesOriGene Antibodies for ENSA
- Novus Biologicals Antibodies for ENSA
- Invitrogen Antibodies for ENSA
- antibodies-online Antibodies for ENSA: See all 60
- GeneTex ENSA antibody for ENSA
-
Santa Cruz Biotechnology (SCBT) Antibodies for ENSA
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ENSA
- Origene Custom Protein Services for ENSA
- Sino Biological Recombinant Proteins for ENSA
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for ENSA
- antibodies-online Proteins for ENSA: See all 29
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ENSA
-
ProSci Proteins for ENSA
Assay Products
- antibodies-online Kits for ENSA: See all 12
No data available for DME Specific Peptides for ENSA Gene
Domains & Families for ENSA Gene
Protein Domains for ENSA Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ENSA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O43768- Family:
-
- Belongs to the endosulfine family.
No data available for Gene Families for ENSA Gene
Function for ENSA Gene
Molecular function for ENSA Gene
- GENATLAS Biochemistry:
- alpha endosulfine,endogenous regulator of the beta-cell K (ATP) channel,inhibiting sulfonylurea binding to beta cell membranes and stimulating insulin secretion
- UniProtKB/Swiss-Prot Function:
- Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004864 | protein phosphatase inhibitor activity | IBA,IEA | -- |
| GO:0005102 | receptor binding | IDA | 9653196 |
| GO:0005515 | protein binding | IPI | 21044950 |
| GO:0008200 | ion channel inhibitor activity | TAS | 9653196 |
| GO:0019212 | phosphatase inhibitor activity | ISS | -- |
Phenotypes for ENSA Gene
- GenomeRNAi human phenotypes for ENSA:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased shRNA abundance
Animal Model Products
-
Taconic Biosciences Mouse Models for ENSA
- Cyagen custom Knockout/knockin (KOKI) mouse models for ENSA
-
- Search ViGene Biosciences for ENSA
CRISPR Products
-
OriGene CRISPR knockouts for ENSA
-
Santa Cruz Biotechnology (SCBT) CRISPR for ENSA
- GenScript: Design CRISPR guide RNA sequences for ENSA
miRNA for ENSA Gene
- miRTarBase miRNAs that target ENSA
-
- hsa-mir-877-3p (MIRT036994)
- hsa-let-7e-5p (MIRT051695)
- hsa-mir-4668-5p (MIRT560470)
- hsa-mir-6077 (MIRT560471)
- hsa-mir-7-5p (MIRT560472)
- hsa-mir-6124 (MIRT560473)
- hsa-mir-873-3p (MIRT560474)
- hsa-mir-5584-5p (MIRT560475)
- hsa-mir-4463 (MIRT560476)
- hsa-mir-6873-5p (MIRT560477)
- hsa-mir-4428 (MIRT560478)
- hsa-mir-6836-3p (MIRT636572)
- hsa-mir-5001-3p (MIRT636573)
- hsa-mir-4284 (MIRT636574)
- hsa-mir-6829-3p (MIRT636575)
- hsa-mir-6791-3p (MIRT636576)
- hsa-mir-6778-3p (MIRT636577)
- hsa-mir-4638-5p (MIRT636578)
- hsa-mir-1307-3p (MIRT636579)
- hsa-mir-1304-3p (MIRT636580)
- hsa-mir-6741-3p (MIRT636581)
- hsa-mir-6890-3p (MIRT636582)
- hsa-mir-6848-3p (MIRT676871)
- hsa-mir-6843-3p (MIRT676872)
- hsa-mir-6878-3p (MIRT676873)
- hsa-mir-640 (MIRT676874)
- hsa-mir-378a-5p (MIRT676875)
- hsa-mir-6744-3p (MIRT676876)
- hsa-mir-4757-5p (MIRT676877)
- hsa-mir-6821-3p (MIRT676878)
- hsa-mir-6790-3p (MIRT676879)
- hsa-mir-3663-5p (MIRT676880)
- hsa-mir-3653-5p (MIRT676881)
- hsa-mir-372-5p (MIRT676882)
- hsa-mir-371a-5p (MIRT676883)
- hsa-mir-616-5p (MIRT676884)
- hsa-mir-373-5p (MIRT676885)
- hsa-mir-371b-5p (MIRT676886)
- hsa-mir-212-5p (MIRT676887)
- hsa-mir-1224-3p (MIRT676888)
- hsa-mir-6513-3p (MIRT676889)
- hsa-mir-8079 (MIRT676890)
- hsa-mir-1245a (MIRT676891)
- hsa-mir-6813-3p (MIRT676892)
miRNA Products
- Search ViGene Biosciences for ENSA
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ENSA
- Browse OriGene Inhibitory RNA Products For ENSA
Clone Products
-
OriGene ORF clones in human for ENSA
- RC219133L1
- RC219133L2
- RG219133
- RC209655
- RG209655
- RC209655L2
- RC209655L1
- RC219133
- RG220539
- RC220539L2
- RC220539L1
- RC220539
- RG220497
- RC220497L2
- RC220497L1
- RC220497
- RG209836
- RC209836L2
- RC209836L1
- RC209836
- RG214225
- RC214225L2
- RC214225L1
- RC214225
- RG220441
- RC220441L2
- RC220441L1
- RC220441
- RG201350
- RC201350L2
- RC201350L1
- RC201350
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ENSA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ENSA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ENSA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ENSA
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENSA Gene
Localization for ENSA Gene
Subcellular locations from UniProtKB/Swiss-Prot for ENSA Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| cytoskeleton | 2 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA,IEA | -- |
Pathways & Interactions for ENSA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell Cycle, Mitotic |
.83
|
.60
|
| 2 | Mitotic Prophase |
.57
|
|
| 3 | DNA Damage | ||
Pathways by source for ENSA Gene
1 Cell Signaling Technology pathway for ENSA Gene
5 Reactome pathways for ENSA Gene
Interacting Proteins for ENSA Gene
Selected Interacting proteins:
O43768-ENSA_HUMAN
ENSP00000341743
for ENSA Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | ISS | -- |
| GO:0000278 | mitotic cell cycle | ISS | -- |
| GO:0006810 | transport | TAS | 9653196 |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007067 | mitotic nuclear division | ISS | -- |
No data available for SIGNOR curated interactions for ENSA Gene
Transcripts for ENSA Gene
mRNA/cDNA for ENSA Gene
- (8) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (766) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ENSA
-
Santa Cruz Biotechnology (SCBT) CRISPR for ENSA
- GenScript: Design CRISPR guide RNA sequences for ENSA
miRNA Products
- Search ViGene Biosciences for ENSA
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ENSA
- Browse OriGene Inhibitory RNA Products For ENSA
Clone Products
-
OriGene ORF clones in human for ENSA
- RC219133L1
- RC219133L2
- RG219133
- RC209655
- RG209655
- RC209655L2
- RC209655L1
- RC219133
- RG220539
- RC220539L2
- RC220539L1
- RC220539
- RG220497
- RC220497L2
- RC220497L1
- RC220497
- RG209836
- RC209836L2
- RC209836L1
- RC209836
- RG214225
- RC214225L2
- RC214225L1
- RC214225
- RG220441
- RC220441L2
- RC220441L1
- RC220441
- RG201350
- RC201350L2
- RC201350L1
- RC201350
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ENSA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ENSA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ENSA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | ^ | 6a | · | 6b | · | 6c | · | 6d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - |
Expression for ENSA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Lavage (23.6) and Nasal epithelium (14.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ENSA Gene
NURSA nuclear receptor signaling pathways regulating expression of ENSA Gene:
ENSASOURCE GeneReport for Unigene cluster for ENSA Gene:
Hs.632456mRNA Expression by UniProt/SwissProt for ENSA Gene:
O43768-ENSA_HUMAN
Tissue specificity:
Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas.
Evidence on tissue expression from TISSUES for ENSA Gene
- Nervous system(4.9)
- Lung(4.8)
- Liver(4.3)
- Eye(3)
- Pancreas(3)
- Intestine(2.5)
- Muscle(2.1)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs for ENSA
-
OriGene qPCR primer pairs and template standards for ENSA
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENSA Gene
Orthologs for ENSA Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ENSA 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ENSA 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ENSA 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ENSA 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ensa 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ensa 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ENSA 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ENSA 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ENSA 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ensa 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68564 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ensab 34 35 |
|
||
| ensaa 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | endos 35 |
|
OneToMany |
- Species where no ortholog for ENSA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ENSA Gene
(14) SIMAP similar genes for ENSA Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for ENSA Gene
Variants for ENSA Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000223236 | -- | 150,630,035(+) | GCGCG(C/G)TGCCT | upstream-variant-2KB | |
| rs1000836365 | -- | 150,629,556(+) | TGCGC(G/T)GCTGC | upstream-variant-2KB, utr-variant-5-prime | |
| rs1001396202 | -- | 150,622,307(+) | TCTCA(A/G)CTAGC | utr-variant-3-prime | |
| rs1001562095 | -- | 150,626,706(+) | GCCCG(-/CC)CCACC | intron-variant, downstream-variant-500B | |
| rs1001779737 | -- | 150,629,829(+) | TGCAG(C/G)TTTGG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv24209 | CNV | loss | 19812545 |
| nsv1006838 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
47.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.35;
7.75% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ENSA Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENSA Gene
Disorders for ENSA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diabetes mellitus, insulin-dependent, 11 |
|
|
Search ENSA in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ENSA
No data available for UniProtKB/Swiss-Prot and Genatlas for ENSA Gene
Publications for ENSA Gene
- The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians. (PMID: 14728987) Thameem F. … Prochazka M. (Mol. Genet. Metab. 2004) 3 4 22 64
- Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta- cell K(ATP) channels. (PMID: 10480622) Heron L. … Bataille D. (Diabetes 1999) 3 4 22 64
- Human alpha-endosulfine, a possible regulator of sulfonylurea- sensitive K(ATP) channel: molecular cloning, expression and biological properties. (PMID: 9653196) Heron L. … Bataille D. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 64
- Membrane-induced folding of the cAMP-regulated phosphoprotein endosulfine-alpha. (PMID: 18973346) Boettcher J.M. … Rienstra C.M. (Biochemistry 2008) 3 4 64
- Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy. (PMID: 17893145) Woods W.S. … George J.M. (J. Biol. Chem. 2007) 3 4 64
Products for ENSA Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ENSA
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ENSA
- Origene Custom Protein Services for ENSA
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ENSA
- Browse OriGene Inhibitory RNA Products For ENSA
- OriGene qPCR primer pairs and template standards for ENSA
- OriGene qPCR primer pairs for ENSA
- OriGene CRISPR knockouts for ENSA
- OriGene ORF clones in human for ENSA
- RC201350
- RC201350L1
- RC201350L2
- RG201350
- RC220441
- RC220441L1
- RC220441L2
- RG220441
- RC214225
- RC214225L1
- RC214225L2
- RG214225
- RC209836
- RC209836L1
- RC209836L2
- RG209836
- RC220497
- RC220497L1
- RC220497L2
- RG220497
- RC220539
- RC220539L1
- RC220539L2
- RG220539
- RC219133
- RC219133L1
- RC219133L2
- RG219133
- RC209655
- RC209655L1
- RC209655L2
- RG209655
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ENSA
- GenScript: Next-day shipping cDNA ORF clone for ENSA in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ENSA
- GenScript Custom Assay Services for ENSA
- GenScript Custom overexpressing Cell Line Services for ENSA
- GenScript: Design CRISPR guide RNA sequences for ENSA
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ENSA
- Cell Signaling Technology (CST) Antibodies for ENSA (ENSA)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for ENSA
- Sino Biological Recombinant Proteins for ENSA
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for ENSA
- Novus Biologicals proteins and lysates for ENSA
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for ENSA
- Taconic Biosciences Mouse Models for ENSA
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for ENSA: See all 60
- antibodies-online Kits for ENSA: See all 12
- antibodies-online Proteins for ENSA: See all 29
- Search antibodies-online for peptides
- GeneTex ENSA antibody for ENSA
- Search GeneTex for Proteins for ENSA
- Search ViGene Biosciences for ENSA
- Santa Cruz Biotechnology (SCBT) Antibodies for ENSA
- Search Santa Cruz Biotechnology (SCBT) for ENSA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ENSA
- Search for ENSA Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for ENSA
- Horizon Cell Lines for ENSA
- Cyagen custom Knockout/knockin (KOKI) mouse models for ENSA
- VectorBuilder custom plasmid, inducible vectors for ENSA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ENSA
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ENSA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer