Aliases for ENSA Gene
Aliases for ENSA Gene
External Ids for ENSA Gene
- HGNC: 3360
- Entrez Gene: 2029
- Ensembl: ENSG00000143420
- OMIM: 603061
- UniProtKB: O43768
Previous GeneCards Identifiers for ENSA Gene
- GC01M148437
- GC01M146342
- GC01M147368
- GC01M147811
- GC01M147408
- GC01M148840
- GC01M148861
- GC01M150574
- GC01M121972
- GC01M150577
- GC01M150595
- GC01M150601
- GC01M150606
- GC01M150611
- GC01M150614
- GC01M150617
- GC01M150621
Summaries for ENSA Gene
-
The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
GeneCards Summary for ENSA Gene
ENSA (Endosulfine Alpha) is a Protein Coding gene. Diseases associated with ENSA include Type 1 Diabetes Mellitus 11. Among its related pathways are Mitotic Prophase and DNA Damage. Gene Ontology (GO) annotations related to this gene include receptor binding. An important paralog of this gene is ARPP19.
UniProtKB/Swiss-Prot for ENSA Gene
-
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENSA Gene
Genomics for ENSA Gene
GeneHancer (GH) Regulatory Elements for ENSA Gene
Regulatory Element Products
Genomic Locations for ENSA Gene
- chr1:150,600,851-150,629,622
- (GRCh38/hg38)
- Size:
- 28,772 bases
- Orientation:
- Minus strand
- chr1:150,573,327-150,602,098
- (GRCh37/hg19)
Genomic View for ENSA Gene
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC


RefSeq DNA sequence for ENSA Gene
Proteins for ENSA Gene
-
Protein details for ENSA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43768-ENSA_HUMAN
- Recommended name:
- Alpha-endosulfine
- Protein Accession:
- O43768
- A8K1Z9
- E9PB69
- Q5T5H2
- Q68D48
- Q6FHW0
- Q6IAM4
- Q6NUL2
- Q6VUC6
- Q6VUC7
- Q6VUC8
- Q6VUC9
- Q6VUD0
- Q6VUD1
- Q9NRZ0
Protein attributes for ENSA Gene
- Size:
- 121 amino acids
- Molecular mass:
- 13389 Da
- Quaternary structure:
-
- Interacts (when phosphorylated at Ser-67) with PPP2R2D (By similarity). Interacts with ABCC8. Interacts with SNCA; interaction is disrupted when phosphorylated at Ser-109.
Protein Expression for ENSA Gene
Post-translational modifications for ENSA Gene
- Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA.
Other Protein References for ENSA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for ENSA (ENSA)
-
Custom Antibody ServicesOriGene Antibodies for ENSA
- Novus Biologicals Antibodies for ENSA
-
Abcam antibodies for ENSA
- Invitrogen Antibodies for ENSA
- GeneTex ENSA antibody for ENSA
-
Santa Cruz Biotechnology (SCBT) Antibodies for ENSA
- Sino Biological Antibodies for ENSA
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ENSA
- Origene Custom Protein Services for ENSA
- Sino Biological Recombinant Proteins for ENSA
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for ENSA
- Search GeneTex for Proteins for ENSA
-
ProSci Proteins for ENSA
-
Abcam proteins for ENSA
Assay Products
- antibodies-online: Search results for 11 available Ensa Elisa Kits ranked by validation data
- Compare Top Ensa Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ENSA Gene
Domains & Families for ENSA Gene
Gene Families for ENSA Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ENSA Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ENSA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O43768- Family:
-
- Belongs to the endosulfine family.
Function for ENSA Gene
Molecular function for ENSA Gene
- GENATLAS Biochemistry:
- alpha endosulfine,endogenous regulator of the beta-cell K (ATP) channel,inhibiting sulfonylurea binding to beta cell membranes and stimulating insulin secretion
- UniProtKB/Swiss-Prot Function:
- Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
Phenotypes From GWAS Catalog for ENSA Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004864 | protein phosphatase inhibitor activity | IBA | -- |
GO:0005102 | receptor binding | IDA | 9653196 |
GO:0005515 | protein binding | IPI | 21044950 |
GO:0008200 | ion channel inhibitor activity | TAS | 9653196 |
GO:0019212 | phosphatase inhibitor activity | ISS | -- |
Phenotypes for ENSA Gene
- GenomeRNAi human phenotypes for ENSA:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased shRNA abundance
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ENSA
-
- Search ViGene Biosciences for ENSA
CRISPR Products
-
OriGene CRISPR knockouts for ENSA
- genomics-online: gRNA clones - Search results for 206 available Ensa gene related products
- Overview of 206 available Ensa gene related products
-
Recommended
- Applied Biological Materials CRISPR for ENSA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ENSA
- GenScript: Design CRISPR guide RNA sequences for ENSA
miRNA for ENSA Gene
- miRTarBase miRNAs that target ENSA
-
- hsa-mir-877-3p (MIRT036994)
- hsa-let-7e-5p (MIRT051695)
- hsa-mir-4668-5p (MIRT560470)
- hsa-mir-6077 (MIRT560471)
- hsa-mir-7-5p (MIRT560472)
- hsa-mir-6124 (MIRT560473)
- hsa-mir-873-3p (MIRT560474)
- hsa-mir-5584-5p (MIRT560475)
- hsa-mir-4463 (MIRT560476)
- hsa-mir-6873-5p (MIRT560477)
- hsa-mir-4428 (MIRT560478)
- hsa-mir-6836-3p (MIRT636572)
- hsa-mir-5001-3p (MIRT636573)
- hsa-mir-4284 (MIRT636574)
- hsa-mir-6829-3p (MIRT636575)
- hsa-mir-6791-3p (MIRT636576)
- hsa-mir-6778-3p (MIRT636577)
- hsa-mir-4638-5p (MIRT636578)
- hsa-mir-1307-3p (MIRT636579)
- hsa-mir-1304-3p (MIRT636580)
- hsa-mir-6741-3p (MIRT636581)
- hsa-mir-6890-3p (MIRT636582)
- hsa-mir-6848-3p (MIRT676871)
- hsa-mir-6843-3p (MIRT676872)
- hsa-mir-6878-3p (MIRT676873)
- hsa-mir-640 (MIRT676874)
- hsa-mir-378a-5p (MIRT676875)
- hsa-mir-6744-3p (MIRT676876)
- hsa-mir-4757-5p (MIRT676877)
- hsa-mir-6821-3p (MIRT676878)
- hsa-mir-6790-3p (MIRT676879)
- hsa-mir-3663-5p (MIRT676880)
- hsa-mir-3653-5p (MIRT676881)
- hsa-mir-372-5p (MIRT676882)
- hsa-mir-371a-5p (MIRT676883)
- hsa-mir-616-5p (MIRT676884)
- hsa-mir-373-5p (MIRT676885)
- hsa-mir-371b-5p (MIRT676886)
- hsa-mir-212-5p (MIRT676887)
- hsa-mir-1224-3p (MIRT676888)
- hsa-mir-6513-3p (MIRT676889)
- hsa-mir-8079 (MIRT676890)
- hsa-mir-1245a (MIRT676891)
- hsa-mir-6813-3p (MIRT676892)
miRNA Products
- Search ViGene Biosciences for ENSA
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ENSA
- Browse OriGene Inhibitory RNA Products For ENSA
- genomics-online: shRNA clones - Search results for 206 available Ensa gene related products
- Overview of 206 available Ensa gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for ENSA
- RG209655
- RC209655L2
- RC209655L1
- RC209655
- RG219133
- RC219133L2
- RC219133L1
- RC219133
- RG220539
- RC220539L2
- RC220539L1
- RC220539
- RG220497
- RC220497L2
- RC220497L1
- RC220497
- RG209836
- RC209836L2
- RC209836L1
- RC209836
- RG214225
- RC214225L2
- RC214225L1
- RC214225
- RG220441
- RC220441L2
- RC220441L1
- RC220441
- RG201350
- RC201350L2
- RC201350L1
- RC201350
- RC209655L2V
- RC209655L1V
- RC219133L2V
- RC219133L1V
- RC220539L2V
- RC220539L1V
- RC220497L2V
- RC220497L1V
- RC209836L2V
- RC209836L1V
- RC214225L2V
- RC214225L1V
- RC220441L2V
- RC220441L1V
- RC201350L2V
- RC201350L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ENSA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ENSA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ENSA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 206 available Ensa gene related products
- Overview of 206 available Ensa gene related products
-
Recommended
- orf clones - Search results for 206 available Ensa gene related products
- Overview of 206 available Ensa gene related products
-
Recommended
- Applied Biological Materials Clones for ENSA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ENSA
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENSA Gene
Localization for ENSA Gene
Subcellular locations from UniProtKB/Swiss-Prot for ENSA Gene
- Cytoplasm.
- Cytosol (2)
- Microtubules (2)
- Nucleoli (2)
- Nucleus (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA | -- |
Pathways & Interactions for ENSA Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell Cycle, Mitotic |
.83
|
.60
|
2 | Mitotic Prophase |
.57
|
|
3 | DNA Damage |
Pathways by source for ENSA Gene
1 Cell Signaling Technology pathway for ENSA Gene
5 Reactome pathways for ENSA Gene
Interacting Proteins for ENSA Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000086 | G2/M transition of mitotic cell cycle | ISS | -- |
GO:0000278 | mitotic cell cycle | ISS | -- |
GO:0006810 | transport | TAS | 9653196 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007584 | response to nutrient | TAS | 9653196 |
No data available for SIGNOR curated interactions for ENSA Gene
Transcripts for ENSA Gene
mRNA/cDNA for ENSA Gene
- (8) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (766) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ENSA
- genomics-online: gRNA clones - Search results for 206 available Ensa gene related products
- Overview of 206 available Ensa gene related products
-
Recommended
- Applied Biological Materials CRISPR for ENSA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ENSA
- GenScript: Design CRISPR guide RNA sequences for ENSA
miRNA Products
- Search ViGene Biosciences for ENSA
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ENSA
- Browse OriGene Inhibitory RNA Products For ENSA
- genomics-online: shRNA clones - Search results for 206 available Ensa gene related products
- Overview of 206 available Ensa gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for ENSA
- RG209655
- RC209655L2
- RC209655L1
- RC209655
- RG219133
- RC219133L2
- RC219133L1
- RC219133
- RG220539
- RC220539L2
- RC220539L1
- RC220539
- RG220497
- RC220497L2
- RC220497L1
- RC220497
- RG209836
- RC209836L2
- RC209836L1
- RC209836
- RG214225
- RC214225L2
- RC214225L1
- RC214225
- RG220441
- RC220441L2
- RC220441L1
- RC220441
- RG201350
- RC201350L2
- RC201350L1
- RC201350
- RC209655L2V
- RC209655L1V
- RC219133L2V
- RC219133L1V
- RC220539L2V
- RC220539L1V
- RC220497L2V
- RC220497L1V
- RC209836L2V
- RC209836L1V
- RC214225L2V
- RC214225L1V
- RC220441L2V
- RC220441L1V
- RC201350L2V
- RC201350L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ENSA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ENSA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ENSA
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 206 available Ensa gene related products
- Overview of 206 available Ensa gene related products
-
Recommended
- orf clones - Search results for 206 available Ensa gene related products
- Overview of 206 available Ensa gene related products
-
Recommended
- Applied Biological Materials Clones for ENSA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | ^ | 6a | · | 6b | · | 6c | · | 6d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - |
Expression for ENSA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ENSA Gene
NURSA nuclear receptor signaling pathways regulating expression of ENSA Gene:
ENSASOURCE GeneReport for Unigene cluster for ENSA Gene:
Hs.632456mRNA Expression by UniProt/SwissProt for ENSA Gene:
O43768-ENSA_HUMANEvidence on tissue expression from TISSUES for ENSA Gene
- Nervous system(4.9)
- Lung(4.8)
- Liver(4.3)
- Eye(3)
- Pancreas(3)
- Intestine(2.5)
- Muscle(2.1)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs for ENSA
-
OriGene qPCR primer pairs and template standards for ENSA
- genomics-online: primer clones - Search results for 206 available Ensa gene related products
- Overview of 206 available Ensa gene related products
-
Recommended
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENSA Gene
Orthologs for ENSA Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ENSA 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | ENSA 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | ENSA 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | ENSA 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Ensa 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Ensa 33 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | ENSA 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | ENSA 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | ENSA 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | ensa 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | MGC68564 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | ensab 33 34 |
|
||
ensaa 34 |
|
OneToMany | |||
fruit fly (Drosophila melanogaster) |
Insecta | endos 34 |
|
OneToMany |
- Species where no ortholog for ENSA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ENSA Gene
(14) SIMAP similar genes for ENSA Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for ENSA Gene
Variants for ENSA Gene
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000223236 | -- | 150,630,035(-) | G/C | upstream_transcript_variant | |
rs1000836365 | -- | 150,629,556(-) | T/G | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
rs1001396202 | -- | 150,622,307(-) | A/G | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
rs1001562095 | -- | 150,626,707(-) | CC/CCCC | downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant | |
rs1001779737 | -- | 150,629,829(-) | C/G | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv24209 | CNV | loss | 19812545 |
nsv1006838 | CNV | gain | 25217958 |
Additional Variant Information for ENSA Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENSA Gene
Disorders for ENSA Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
type 1 diabetes mellitus 11 |
|
|
Additional Disease Information for ENSA
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ENSA Gene
Publications for ENSA Gene
- The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians. (PMID: 14728987) Thameem F … Prochazka M (Molecular genetics and metabolism 2004) 3 4 22 58
- Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels. (PMID: 10480622) Héron L … Bataille D (Diabetes 1999) 3 4 22 58
- Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties. (PMID: 9653196) Heron L … Bataille D (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 58
- Membrane-induced folding of the cAMP-regulated phosphoprotein endosulfine-alpha. (PMID: 18973346) Boettcher JM … Rienstra CM (Biochemistry 2008) 3 4 58
- Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy. (PMID: 17893145) Woods WS … George JM (The Journal of biological chemistry 2007) 3 4 58
Products for ENSA Gene
- Browse R&D Systems for Antibodies
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ENSA
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ENSA
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for ENSA
- Browse OriGene Inhibitory RNA Products For ENSA
- OriGene qPCR primer pairs and template standards for ENSA
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- OriGene ORF clones in human for ENSA
- RC201350L1V
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ENSA
- GenScript: Next-day shipping of latest version cDNA ORF clones for ENSA in any vector
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- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
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- Cell Signaling Technology (CST) Antibodies for ENSA (ENSA)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for ENSA
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ENSA
- Novus Biologicals lysates and proteins for ENSA
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- Abcam antibodies for ENSA
- Abcam proteins for ENSA
- Find your target
- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for ENSA
- Browse Antibodies at Cloud-Clone Corp.
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- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for ENSA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for ENSA
- VectorBuilder custom plasmid, inducible vectors for ENSA
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ENSA
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 65 available Ensa Antibodies ranked by validation data
- Compare Top Ensa Antibodies
- antibodies-online: Search results for 11 available Ensa Elisa Kits ranked by validation data
- Compare Top Ensa Elisa Kits
- Quality Products:
- antibodies-online: Search results for 27 available Ensa Proteins ranked by validation data
- Compare Top Ensa Proteins
- GeneTex ENSA antibody for ENSA
- Search GeneTex for Proteins for ENSA
- Search ViGene Biosciences for ENSA
- Santa Cruz Biotechnology (SCBT) Antibodies for ENSA
- Search Santa Cruz Biotechnology (SCBT) for ENSA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ENSA
- Search for ENSA Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for ENSA
- Horizon Cell Lines for ENSA
- genomics-online: cdna clones - Search results for 206 available Ensa gene related products
- Overview of 206 available Ensa gene related products
- Recommended
- orf clones - Search results for 206 available Ensa gene related products
- Overview of 206 available Ensa gene related products
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- genomics-online: gRNA clones - Search results for 206 available Ensa gene related products
- Overview of 206 available Ensa gene related products
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- genomics-online: primer clones - Search results for 206 available Ensa gene related products
- Overview of 206 available Ensa gene related products
- Recommended
- genomics-online: shRNA clones - Search results for 206 available Ensa gene related products
- Overview of 206 available Ensa gene related products
- Recommended
Sources for ENSA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew