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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ENSA Gene

protein-coding   GIFtS: 55
GCID: GC01M150574

endosulfine alpha
 Explore 3 diseases affiliated with
ENSA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ENSA    

Aliases
for ENSA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Endosulfine Alpha1 2
ARPP-19e1 2 3
MGC43191
MGC785631
MGC83941
Alpha-Endosulfine1

External Ids:    HGNC: 33601   Entrez Gene: 20292   Ensembl: ENSG000001434207   OMIM: 6030615   UniProtKB: O437683   

Export aliases for ENSA gene to outside databases

Previous GC identifers: GC01M148437 GC01M146342 GC01M147368 GC01M147811 GC01M147408 GC01M148840 GC01M148861 GC01M121972


Summaries
for ENSA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ENSA:
The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This
protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory
subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta
cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be
an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin
secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2
diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ENSA_HUMAN, O43768
Function: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When
phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity,
leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By
similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby
preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents

Gene Wiki entry for ENSA


Genomic Views
for ENSA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ENSA gene promoter:
         HOXA9   HOXA9B   p53   AML1a   CP2   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ENSA promoter sequence
   Search SABiosciences Chromatin IP Primers for ENSA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENSA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

ENSA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ENSA gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M150574:  view genomic region     (about GC identifiers)

Start:
 150,573,327 bp from pter      End:
 150,602,098 bp from pter
Size:
 28,772 bases      Orientation:
 minus strand

Proteins
for ENSA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ENSA_HUMAN, O43768 (See protein sequence)
Recommended Name: Alpha-endosulfine  
Size: 121 amino acids; 13389 Da
Subunit: Interacts (when phosphorylated at Ser-67) with PPP2R2D (By similarity). Interacts with ABCC8. Interacts with
SNCA; interaction is disrupted when phosphorylated at Ser-109
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: A8K1Z9 E9PB69 Q5T5H2 Q68D48 Q6FHW0 Q6IAM4 Q6NUL2 Q6VUC6 Q6VUC7 Q6VUC8 Q6VUC9
Q6VUD0 Q6VUD1 Q9NRZ0
Alternative splicing: 9 isoforms:  O43768-1   O43768-2   O43768-3   O43768-4   O43768-5   O43768-6   O43768-7   O43768-8   
O43768-9   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ENSA: NX_O43768

Post-translational modifications:

  • Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent
    • inactivation of PP2A (By similarity). Phosphorylated by PKA1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43768

    • ENSA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (8 alternative transcripts): 
    NP_004427.1  NP_996925.1  NP_996926.1  NP_996927.1  NP_996928.1  NP_996929.1  NP_996930.1  NP_997051.1  

    ENSEMBL proteins: 
     ENSP00000358012   ENSP00000358010   ENSP00000354835   ENSP00000355239   ENSP00000426110  
     ENSP00000341743   ENSP00000271690   ENSP00000348921   ENSP00000426952   ENSP00000422343  
     ENSP00000421458   ENSP00000424242   ENSP00000355220   ENSP00000358005  
    Reactome Protein details: O43768
    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): ENSA
    OriGene Protein Over-expression Lysate (see all 3): ENSA
    OriGene Custom Protein Services for ENSA 
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    Novus Biologicals ENSA Proteins
    Novus Biologicals ENSA Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for ENSA
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--


    ENSA for ontologies           About GeneDecksing



    ENSA Antibody Products: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for ENSA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ENSA for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR006760 Endosulphine

    Graphical View of Domain Structure for InterPro Entry O43768

    ProtoNet protein and cluster: O43768

    1 Blocks protein family: IPB006760 cAMP-regulated phosphoprotein/endosulfine conserved region

    UniProtKB/Swiss-Prot: ENSA_HUMAN, O43768
    Similarity: Belongs to the endosulfine family


    Function
    for ENSA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ENSA_HUMAN, O43768
    Function: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When
    phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity,
    leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By
    similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby
    preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents

         Genatlas biochemistry entry for ENSA:
    alpha endosulfine,endogenous regulator of the beta-cell K (ATP) channel,inhibiting sulfonylurea binding to beta cell
    membranes and stimulating insulin secretion

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ENSA
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate ENSA (see all 31):
    hsa-miR-136 hsa-miR-331-3p hsa-miR-374a hsa-miR-486-3p hsa-miR-138-2* hsa-miR-410 hsa-miR-766 hsa-miR-103a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ENSA (see all 7)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ENSA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ENSA

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ENSA (see all 12)
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    Cell Line
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    Search LifeMap BioReagents cell lines for ENSA

    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004864protein phosphatase inhibitor activity IEA--
    GO:0005102receptor binding TAS9653196
    GO:0008200ion channel inhibitor activity TAS9653196
    GO:0008601protein phosphatase type 2A regulator activity ISS--
    GO:0019212phosphatase inhibitor activity ISS--


    ENSA for ontologies           About GeneDecksing



    Pathways & Interactions
    for ENSA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1M Phase
    		M Phase1.00
    		Mitotic M-M/G1 phases0.88
    2Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84
    3Cell Cycle / Checkpoint Control
    		Cell Cycle / Checkpoint Control1.00
    4Clearance of Nuclear Envelope Membranes from Chromatin
    		Mitotic Prophase0.26
    5ERK/MAPK targets
    		MASTL Facilitates Mitotic Progression0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ENSA
        Cell Cycle / Checkpoint Control

    5/6        Reactome Pathways for ENSA (see all 6)
        Mitotic Prophase
    Cell Cycle
    M Phase
    MASTL Facilitates Mitotic Progression
    Mitotic M-M/G1 phases



    ENSA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ENSA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/13 Interacting proteins for ENSA (O437681, 2, 3 ENSP000003417434) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARIH2O953762, 3MINT-63298 I2D: score=5 
    ENO2P091042, 3MINT-63435 I2D: score=4 
    KCTD15Q96SI12, 3MINT-65372 I2D: score=4 
    MCM3P252051, 3, ENSP000002298544EBI-714511,EBI-355153 I2D: score=2 STRING: ENSP00000229854
    ABCC8Q094283, ENSP000003744674I2D: score=2 STRING: ENSP00000374467
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle ISS--
    GO:0006810transport TAS9653196
    GO:0007067mitosis ISS--
    GO:0007584response to nutrient TAS9653196
    GO:0009749response to glucose stimulus IEA--


    ENSA for ontologies           About GeneDecksing



    Drugs & Compounds
    for ENSA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ENSA
    Search CenterWatch for drugs/clinical trials and news about ENSA 

    Transcripts
    for ENSA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ENSA gene (8 alternative transcripts): 
    NM_004436.2  NM_207042.1  NM_207043.1  NM_207044.1  NM_207045.1  NM_207046.1  NM_207047.1  NM_207168.1  

    Unigene Cluster for ENSA:

    Endosulfine alpha
    Hs.632456  [show with all ESTs]
    Unigene Representative Sequence: NM_207043
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369016 ENST00000369014(uc001evb.3 uc001evc.3 uc001evd.3 uc001eve.3)
    ENST00000361532 ENST00000361631 ENST00000509582 ENST00000339643 ENST00000271690(uc001evf.3 uc001evg.3 uc001evh.3)
    ENST00000356527(uc009wly.3) ENST00000502246 ENST00000513281 ENST00000505321
    ENST00000503345 ENST00000354702 ENST00000503241 ENST00000362052(uc001evi.3)
    ENST00000369009(uc009wlz.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ENSA
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate ENSA (see all 31):
    hsa-miR-136 hsa-miR-331-3p hsa-miR-374a hsa-miR-486-3p hsa-miR-138-2* hsa-miR-410 hsa-miR-766 hsa-miR-103a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse OriGene siRNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 8): ENSA (NM_207045)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENSA

    Additional cDNA sequence: 

    AF067170.1 AF157509.1 AF157510.1 AK001981.1 AK290064.1 BC000436.2 BC004461.1 BC068544.1 
    BC069208.1 CR457130.1 CR536578.1 CR749580.1 X99906.1 

    24/34 DOTS entries (see all 34):

    DT.100742886  DT.100742910  DT.443946  DT.95277346  DT.102837884  DT.102837898  DT.102837897  DT.100742893 
    DT.100742888  DT.100742899  DT.312768  DT.99927234  DT.102837882  DT.101958053  DT.99926499  DT.100724588 
    DT.120787261  DT.95283642  DT.97760222  DT.100642581  DT.100847016  DT.100860474  DT.121360926  DT.121361000 

    24/766 AceView cDNA sequences (see all 766):

    AK001981 BC004461 CB155540 AA099687 BQ889046 W79109 AA806496 BX956144 
    AA349184 AA046152 AI670760 BX646398 BM793890 BU679472 AW166163 BM725831 
    BQ005654 BX646321 AA343584 BU726992 AA953841 AA320402 AA357544 BQ052650 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ENSA (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b · 6c · 6d
    SP1:                                -     -     -                 -     -                       -     -     -     -                           
    SP2:                                -     -     -                       -                       -     -     -     -                           
    SP3:                                            -                 -     -                       -     -     -     -                           
    SP4:                                -     -     -                 -     -     -                 -     -     -     -                           
    SP5:                                -     -     -                 -     -                                                                     


    ECgene alternative splicing isoforms for ENSA

    Expression
    for ENSA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ENSA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAAAACCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ENSA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ENSA

    SOURCE GeneReport for Unigene cluster: Hs.632456

    UniProtKB/Swiss-Prot: ENSA_HUMAN, O43768
    Tissue specificity: Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas

        SABiosciences Custom PCR Arrays for ENSA
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    In Situ
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    Orthologs
    for ENSA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ENSA gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ENSA1 endosulfine alpha 80.37(n)
    89.72(a)    		   425073  NM_001007965.1  NP_001007966.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ENSA6
    		 --
    		 76(a)
    		 1 ↔ 1
    		 GL343779.1(157796-166014)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC685642 hypothetical protein MGC68564 79.61(n)    BC063723.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ensab1 endosulfine alpha b 73.51(n)
    83.04(a)    		   100317933  XM_002664912.1  XP_002664958.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta endos6
    		 endosulfine
    		 41(a)
    		 1 → many
    		 3L(14022679-14024806)
    worm
    (Caenorhabditis elegans)    		 Secernentea ensa-16
    		 Protein ENSA-1
    		 22(a)
    		 1 → many
    		 I(9850011-9851784)


    ENSEMBL Gene Tree for ENSA (if available)
    TreeFam Gene Tree for ENSA (if available) 

    Paralogs
    for ENSA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ENSA gene
    ARPP192  
    13 SIMAP similar genes for ENSA using alignment to 5 protein entries:     ENSA_HUMAN (see all proteins):
    NF2    AURA2    ZNF564    FAM175A    LINC00596    TMEM14B
    ARPP19    MYB    DNAPTP3    EIF3L    GLT8D2    HMGA2
    SH3PXD2A

    ENSA for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ENSA
    PGOHUM00000247876 PGOHUM00000247449 PGOHUM00000241105


    Genomic Variants
    for ENSA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/176 NCBI SNPs in ENSA are shown (see all 176)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1124077521,2
    		C,--121971985(+) ATTGGC/TACATC 4 -- ds50011Minor allele frequency- T:0.50NA 2
    rs66821361,2
    		C,F,H,--121972852(+) AATTCA/GTACTC 4 -- ut315Minor allele frequency- G:0.08NS EA WA 536
    rs115819021,2
    		H--121972920(+) TATTTC/GTCCCA 4 -- ut314Minor allele frequency- G:0.00NS EA 418
    rs120322591,2
    		H--121973023(+) GGCTTC/TTGCCT 4 -- ut314Minor allele frequency- T:0.00NS EA 408
    rs8851,2
    		--121973654(+) TTGGAA/GTGACC 7 -- int1 ut310--------
    rs8831,2
    		C,--121973658(+) AATGAC/TCACTC 7 -- int1 ut310--------
    rs1164379461,2
    		C,F,--121973695(+) GCTGTG/AGAAAC 7 -- int1 ut311Minor allele frequency- A:0.03WA 118
    rs8821,2
    		F,--121973701(+) GAAACT/CGGCAA 7 -- int1 ut311Minor allele frequency- C:0.40MN 184
    rs120233001,2
    		--121973717(+) GAATGA/TAGCTT 7 -- int1 ut310--------
    rs49709671,2
    		--121973721(+) GTAGCC/TTGTTT 7 -- int1 ut310--------

    HapMap Linkage Disequilibrium report for ENSA (150573327 - 150602098 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ENSA
         1 CNV: 64911
    Human Gene Mutation Database (HGMD): ENSA

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ENSA
    DNA2.0 Custom Variant and Variant Library Synthesis for ENSA

    Disorders / Diseases
    for ENSA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ENSA for disorders           About GeneDecksing

    OMIM gene information: 603061    OMIM disorders: --

    3 diseases for ENSA:    About MalaCards
    pancreatitis    down syndrome    nephropathy


    Export disorders for ENSA gene to outside databases

    Publications
    for ENSA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ENSA gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with ENSA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human alpha-endosulfine, a possible regulator of sulfonylurea- sensitive K(ATP) channel: molecular cloning, expression and biological properties. (PubMed id 9653196)1, 2, 3 Heron L.... Bataille D. (1998)
    2. The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians. (PubMed id 14728987)1, 2, 9 Thameem F....Prochazka M. (2004)
    3. Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta- cell K(ATP) channels. (PubMed id 10480622)1, 2, 9 Heron L.... Bataille D. (1999)
    4. Membrane-induced folding of the cAMP-regulated phospho protein endosulfine-alpha. (PubMed id 18973346)1, 2 Boettcher J.M....Rienstra C.M. (2008)
    5. Conformation-specific binding of alpha-synuclein to no vel protein partners detected by phage display and NMR spectroscopy. (PubMed id 17893145)1, 2 Woods W.S....George J.M. (2007)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Interactome mapping suggests new mechanistic details u nderlying Alzheimer's disease. (PubMed id 21163940)1 Soler-Lopez M....Aloy P. (2011)

    External Searches for ENSA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ENSA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2029 HGNC: 3360 AceView: ENSA Ensembl:ENSG00000143420 euGenes: HUgn2029
    ECgene: ENSA H-InvDB: ENSA

    Other Databases showing ENSA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ENSA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ENSA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ENSA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ENSA gene:
    Search GeneIP for patents involving ENSA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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