Aliases for ENPP7 Gene
External Ids for ENPP7 Gene
Previous GeneCards Identifiers for ENPP7 Gene
The protein encoded by this gene is an intestinal alkaline sphingomyelin phosphodiesterase that converts sphingomyelin to ceramide and phosphocholine. The encoded protein is anchored in the cell membrane, and it may function to protect the intestinal mucosa from inflammation and tumorigenesis. This protein is glycosylated and also exhibits lysophosphatidylcholine hydrolase activity. [provided by RefSeq, Oct 2016]
GeneCards Summary for ENPP7 Gene
ENPP7 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 7) is a Protein Coding gene. Diseases associated with ENPP7 include Colorectal Cancer. Among its related pathways are Sphingolipid metabolism and sphingomyelin metabolism/ceramide salvage. GO annotations related to this gene include sphingomyelin phosphodiesterase activity. An important paralog of this gene is ENPP5.
UniProtKB/Swiss-Prot for ENPP7 Gene
Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity.