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Aliases for ENPP4 Gene

Aliases for ENPP4 Gene

  • Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (Putative) 2 3
  • Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 4 3 4
  • AP3A Hydrolase 3 4
  • E-NPP 4 3 4
  • AP3Aase 3 4
  • NPP-4 3 4
  • NPP4 3 4
  • Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (Putative Function) 3
  • EC 3.6.1.29 4
  • KIAA0879 4

External Ids for ENPP4 Gene

Previous GeneCards Identifiers for ENPP4 Gene

  • GC06P046099
  • GC06P046144
  • GC06P046205
  • GC06P045820

Summaries for ENPP4 Gene

GeneCards Summary for ENPP4 Gene

ENPP4 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (Putative)) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG). GO annotations related to this gene include sulfuric ester hydrolase activity and bis(5-adenosyl)-triphosphatase activity. An important paralog of this gene is ENPP3.

UniProtKB/Swiss-Prot for ENPP4 Gene

  • Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENPP4 Gene

Genomics for ENPP4 Gene

Regulatory Elements for ENPP4 Gene

Genomic Location for ENPP4 Gene

Chromosome:
6
Start:
46,129,964 bp from pter
End:
46,146,699 bp from pter
Size:
16,736 bases
Orientation:
Plus strand

Genomic View for ENPP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ENPP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENPP4 Gene

Proteins for ENPP4 Gene

  • Protein details for ENPP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6X5-ENPP4_HUMAN
    Recommended name:
    Bis(5-adenosyl)-triphosphatase ENPP4
    Protein Accession:
    Q9Y6X5
    Secondary Accessions:
    • A8K5G1
    • Q7L2N1

    Protein attributes for ENPP4 Gene

    Size:
    453 amino acids
    Molecular mass:
    51641 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ENPP4 Gene

neXtProt entry for ENPP4 Gene

Proteomics data for ENPP4 Gene at MOPED

Post-translational modifications for ENPP4 Gene

  • Glycosylation at Asn 155, Asn 166, Asn 202, Asn 276, and Asn 386
  • Modification sites at PhosphoSitePlus

Other Protein References for ENPP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ENPP4 Gene

Domains & Families for ENPP4 Gene

Protein Domains for ENPP4 Gene

Suggested Antigen Peptide Sequences for ENPP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6X5

UniProtKB/Swiss-Prot:

ENPP4_HUMAN :
  • Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
Family:
  • Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
genes like me logo Genes that share domains with ENPP4: view

No data available for Gene Families for ENPP4 Gene

Function for ENPP4 Gene

Molecular function for ENPP4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
P(1)-P(3)-bis(5-adenosyl) triphosphate + H(2)O = ADP + AMP.
UniProtKB/Swiss-Prot Function:
Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.

Enzyme Numbers (IUBMB) for ENPP4 Gene

Gene Ontology (GO) - Molecular Function for ENPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0046872 metal ion binding IEA --
GO:0047710 bis(5-adenosyl)-triphosphatase activity IDA 22995898
genes like me logo Genes that share ontologies with ENPP4: view

Phenotypes for ENPP4 Gene

GenomeRNAi human phenotypes for ENPP4:
genes like me logo Genes that share phenotypes with ENPP4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENPP4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ENPP4 Gene

Localization for ENPP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENPP4 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ENPP4 Gene COMPARTMENTS Subcellular localization image for ENPP4 gene
Compartment Confidence
extracellular 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ENPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ENPP4: view

Pathways & Interactions for ENPP4 Gene

SuperPathways for ENPP4 Gene

Superpath Contained pathways
1 Pyrimidine metabolism (KEGG)
genes like me logo Genes that share pathways with ENPP4: view

Pathways by source for ENPP4 Gene

1 KEGG pathway for ENPP4 Gene

Interacting Proteins for ENPP4 Gene

Gene Ontology (GO) - Biological Process for ENPP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation IEA --
GO:0008152 metabolic process --
GO:0030194 positive regulation of blood coagulation IDA 22995898
GO:0046130 purine ribonucleoside catabolic process IDA 22995898
genes like me logo Genes that share ontologies with ENPP4: view

No data available for SIGNOR curated interactions for ENPP4 Gene

Drugs & Compounds for ENPP4 Gene

No Compound Related Data Available

Transcripts for ENPP4 Gene

mRNA/cDNA for ENPP4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(122) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ENPP4 Gene

Ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENPP4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENPP4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4
SP1: -
SP2:

Relevant External Links for ENPP4 Gene

GeneLoc Exon Structure for
ENPP4
ECgene alternative splicing isoforms for
ENPP4

Expression for ENPP4 Gene

mRNA expression in normal human tissues for ENPP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ENPP4 Gene

This gene is overexpressed in Nasal epithelium (37.5) and NK cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ENPP4 Gene



SOURCE GeneReport for Unigene cluster for ENPP4 Gene Hs.643497

mRNA Expression by UniProt/SwissProt for ENPP4 Gene

Q9Y6X5-ENPP4_HUMAN
Tissue specificity: Expressed on the surface of vascular endothelia.
genes like me logo Genes that share expression patterns with ENPP4: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ENPP4 Gene

Orthologs for ENPP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ENPP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ENPP4 35
  • 86.24 (n)
  • 86.98 (a)
ENPP4 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ENPP4 35
  • 90.93 (n)
  • 90.04 (a)
ENPP4 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Enpp4 35
  • 84 (n)
  • 82.52 (a)
Enpp4 16
Enpp4 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ENPP4 35
  • 99.93 (n)
  • 99.78 (a)
ENPP4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Enpp4 35
  • 84 (n)
  • 82.74 (a)
oppossum
(Monodelphis domestica)
Mammalia ENPP4 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ENPP4 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ENPP4 35
  • 68.09 (n)
  • 65.65 (a)
ENPP4 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ENPP4 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia enpp4 35
  • 62.25 (n)
  • 60.45 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3357 35
zebrafish
(Danio rerio)
Actinopterygii enpp4 35
  • 60.82 (n)
  • 58.43 (a)
enpp4 36
  • 55 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C01B10.9 37
  • 30 (a)
CELE_C01B10.9 35
  • 46.07 (n)
  • 33.41 (a)
C01B10.9 36
  • 24 (a)
OneToMany
Species with no ortholog for ENPP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENPP4 Gene

ENSEMBL:
Gene Tree for ENPP4 (if available)
TreeFam:
Gene Tree for ENPP4 (if available)

Paralogs for ENPP4 Gene

Paralogs for ENPP4 Gene

(6) SIMAP similar genes for ENPP4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ENPP4: view

Variants for ENPP4 Gene

Sequence variations from dbSNP and Humsavar for ENPP4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs9763 -- 46,146,118(-) CTTAA(C/T)TCAAA utr-variant-3-prime
rs761396 -- 46,137,319(-) ATCAG(C/T)AAATA intron-variant
rs872859 -- 46,138,164(-) TGAAG(A/T)TTAGT intron-variant
rs910179 -- 46,137,760(-) CTGAA(A/T)GTGGT intron-variant
rs1048072 -- 46,143,937(+) ATACT(A/T)CCTCT utr-variant-3-prime

Variation tolerance for ENPP4 Gene

Residual Variation Intolerance Score: 68.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.55; 91.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENPP4 Gene

HapMap Linkage Disequilibrium report
ENPP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ENPP4 Gene

Disorders for ENPP4 Gene

Relevant External Links for ENPP4

Genetic Association Database (GAD)
ENPP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ENPP4
genes like me logo Genes that share disorders with ENPP4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENPP4 Gene

Publications for ENPP4 Gene

  1. Structural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatases. (PMID: 11027689) Gijsbers R. … Bollen M. (J. Biol. Chem. 2001) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. The molecular basis of purinergic signal metabolism by ecto- nucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke. (PMID: 24338010) Albright R.A. … Braddock D.T. (J. Biol. Chem. 2013) 67
  4. NPP4 is a procoagulant enzyme on the surface of vascular endothelium. (PMID: 22995898) Albright R.A. … Braddock D.T. (Blood 2012) 67
  5. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 67

Products for ENPP4 Gene

Sources for ENPP4 Gene

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