ENPP4 Gene
protein-coding GIFtS : 43
GCID: GC06 P046144
ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
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Aliasesfor ENPP4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (Putative) 1 2 E-NPP 42 3 NPP41 2 3 Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (Putative Function)2 KIAA08791 3 Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 42 NPP-42 3 EC 3.1.-.-3
Export aliases for ENPP4 gene to outside databases Previous GC identifers: GC06P046099 GC06P046205 GC06P045820
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Summariesfor ENPP4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor ENPP4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_007592.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ENPP4 gene promoter: E2F-4 E2F-3a E2F-5 C/EBPbeta RFX1 YY1 GATA-1 Egr-2 E2F E2F-1 Other transcription factors Search SABiosciences Chromatin IP Primers for ENPP4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENPP4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p12.3 ENPP4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P046144: view genomic region
(about GC identifiers )
Start:
46,097,701 bp from pter
End:
46,114,436 bp from pter
Size:
16,736 bases
Orientation:
plus strand
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Proteinsfor ENPP4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ENPP4_HUMAN, Q9Y6X5 (See
protein sequence )Recommended Name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 4 precursor Size : 453 amino acids; 51641 Da
Subcellular location : Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions : A8K5G1 Q7L2N1Explore the universe of human proteins at neXtProt for ENPP4: NX_Q9Y6X5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9Y6X5 ENPP4 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_055751.1 ENSEMBL proteins: ENSP00000360454 ENSP00000318066 Human Recombinant Protein Products for ENPP4: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
ENPP4 for ontologies About GeneDecksing ENPP4 Antibody Products: Assay Products for ENPP4:
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Protein
Domains / Familiesfor ENPP4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ENPP4 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9Y6X5 ProtoNet protein and cluster: Q9Y6X5
UniProtKB/Swiss-Prot: ENPP4_HUMAN, Q9Y6X5 Similarity : Belongs to the nucleotide pyrophosphatase/phosphodiesterase family
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Functionfor ENPP4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Enzyme Number (IUBMB): EC 3.1.-.- 1 Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016787 hydrolase activity
IEA --
ENPP4 for ontologies About GeneDecksing Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ENPP4 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ENPP4OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ENPP4 (NM_014936 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ENPP4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ENPP4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENPP4
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Pathways & Interactionsfor ENPP4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ENPP4
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Drugs & Compoundsfor ENPP4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ENPP4 Search CenterWatch for drugs/clinical trials and news about ENPP4
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Transcriptsfor ENPP4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ENPP4 gene: NM_014936.4 Unigene Cluster for ENPP4:
Ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) Hs.643497 [show with all ESTs ] Unigene Representative Sequence: NM_014936 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000371401 ENST00000321037 (uc003oxy.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ENPP4 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ENPP4OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ENPP4 (NM_014936 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ENPP4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ENPP4
Additional cDNA sequence: AB020686.1 AJ420515.1 AK291276.1 BC018054.1
3 DOTS entries : DT.314485 DT.95298965
DT.121319420 24/122 AceView cDNA sequences (see all 122 ):
BI467324 AI890958 AI453683 BI020429 AW572074 AW628034 BG656458 AW089437 AI889993 W32322 AA280236 AL708571 AA494120 AI923781 H65004 AA569130 AW270089 AB020686 AA811403 AA716267 AW473562 AI474880 AI571059 AW304705 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for ENPP4 About this scheme ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 SP1 :     -           SP2 :              
ECgene alternative splicing isoforms for ENPP4
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Expression for ENPP4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ENPP4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATTTTTAAAAAbout this image ENPP4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See ENPP4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ENPP4 SOURCE GeneReport for Unigene cluster: Hs.643497 SABiosciences Custom PCR Arrays for ENPP4 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ENPP4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ENPP4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ENPP4 Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENPP4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENPP4
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Orthologsfor ENPP4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for ENPP4 gene from 9/22 species (see all 22 ) About this table
ENSEMBL Gene Tree for ENPP4 (if available)TreeFam Gene Tree for ENPP4 (if available)
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Paralogsfor ENPP4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ENPP4 gene ENPP3 2 ENPP6 2 ENPP1 2 ENPP5 2 ENPP7 2 ENPP2 2 6 SIMAP similar genes for ENPP4 using alignment to 2 protein entries: ENPP4_HUMAN (see all proteins ):ENPP5 ENPP3 ENPP1 ENPP6 ENPP7 ENPP2
ENPP4 for paralogs About GeneDecksing
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Genomic Variantsfor ENPP4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ENPP4 (46097701 - 46114436 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ENPP4: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ENPP4
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Disorders
/ Diseasesfor ENPP4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor ENPP4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ENPP4 gene integrated from 9 sources : (articles sorted by number of sources associating them with ENPP4) Utopia : connect your pdf to the dynamic world of online information
Structural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatases. (PubMed id 11027689) 1 , 2 , 3 Gijsbers R.... Bollen M. (2001) Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485) 1 , 2 Nagase T....Ohara O. (1998) NPP4 is a procoagulant enzyme on the surface of vascul ar endothelium. (PubMed id 22995898) 1 Albright R.A....Braddock D.T. (2012) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 2 Mungall A.J.... Beck S. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ENPP4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ENPP4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ENPP4 gene
(According to HUGE )
About This Section
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Specialized Databases showing ENPP4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ENPP4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ENPP4 gene: Search GeneIP for patents involving ENPP4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ENPP4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ENPP4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ENPP4 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ENPP4 OriGene 3'-UTR Clone for ENPP4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ENPP4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ENPP4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ENPP4 OriGene Custom Protein Services for ENPP4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ENPP4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ENPP4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENPP4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ENPP4 Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENPP4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ENPP4
Search Tocris compounds for ENPP4
ENPP4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENPP4
Search ThermoFisher Antibodies for ENPP4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ENPP4
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Aliases for ENPP4
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Expression for ENPP4
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Genomic Views for ENPP4
Intellectual Property for ENPP4
Orthologs for ENPP4
Paralogs for ENPP4
Pathways / Interactions for ENPP4
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