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ENPP4 Gene

protein-coding   GIFtS: 50
GCID: GC06P046144

Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (Putative)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (Putative)1 2     E-NPP 42 3
Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 42 3     Bis(5'-Adenosyl)-Triphosphatase ENPP42
AP3Aase2 3     Ectonucleotide Pyrophosphatase/Phosphodiesterase 4 (Putative Function)2
NPP-42 3     EC 3.6.1.293
NPP42 3     KIAA08793
AP3A Hydrolase2 3     

External Ids:    HGNC: 33591   Entrez Gene: 228752   Ensembl: ENSG000000015617   UniProtKB: Q9Y6X53   

Export aliases for ENPP4 gene to outside databases

Previous GC identifers: GC06P046099 GC06P046205 GC06P045820


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ENPP4 Gene:
ENPP4 (ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)) is a protein-coding gene. GO annotations related to this gene include bis(5'-adenosyl)-triphosphatase activity. An important paralog of this gene is ENPP6.

UniProtKB/Swiss-Prot: ENPP4_HUMAN, Q9Y6X5
Function: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine
polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating
platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ENPP4 gene promoter:
         E2F-4   E2F-3a   E2F-5   C/EBPbeta   RFX1   YY1   GATA-1   Egr-2   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidENPP4 promoter sequence
   Search Chromatin IP Primers for ENPP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ENPP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p12.3

ENPP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ENPP4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P046144:  view genomic region     (about GC identifiers)

Start:
46,097,701 bp from pter      End:
46,114,436 bp from pter
Size:
16,736 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ENPP4_HUMAN, Q9Y6X5 (See protein sequence)
Recommended Name: Bis(5'-adenosyl)-triphosphatase ENPP4 precursor  
Size: 453 amino acids; 51641 Da
Cofactor: Binds 2 zinc ions per subunit
2 PDB 3D structures from and Proteopedia for ENPP4:
4LQY (3D)        4LR2 (3D)    
Secondary accessions: A8K5G1 Q7L2N1

Explore the universe of human proteins at neXtProt for ENPP4: NX_Q9Y6X5

Explore proteomics data for ENPP4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn155, Asn166, Asn202, Asn276, Asn386
  • Modification sites at PhosphoSitePlus

  • See ENPP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055751.1  
    ENSEMBL proteins: 
     ENSP00000318066  

    ENPP4 Human Recombinant Protein Products:

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    Novus Biologicals ENPP4 Protein
    Novus Biologicals ENPP4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ENPP4

     
    Search eBioscience for Proteins for ENPP4 

    ENPP4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for ENPP4
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    LSBio Antibodies in human, mouse, rat for ENPP4

    ENPP4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ENPP4
    Cloud-Clone Corp. CLIAs for ENPP4
    Search eBioscience for ELISAs for ENPP4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR002591 Phosphodiest/P_Trfase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR024873 E-NPP
     IPR017850 Alkaline_phosphatase_core

    Graphical View of Domain Structure for InterPro Entry Q9Y6X5

    ProtoNet protein and cluster: Q9Y6X5

    UniProtKB/Swiss-Prot: ENPP4_HUMAN, Q9Y6X5
    Similarity: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family


    Find genes that share domains with ENPP4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ENPP4_HUMAN, Q9Y6X5
    Function: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine
    polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating
    platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors
    Catalytic activity: P(1)-P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP

         Enzyme Number (IUBMB): EC 3.6.1.291

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0008484sulfuric ester hydrolase activity ----
    GO:0046872metal ion binding IEA--
    GO:0047710bis(5'-adenosyl)-triphosphatase activity IDA--
         
    Find genes that share ontologies with ENPP4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ENPP4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ENPP4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ENPP4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ENPP4

    miRNA
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    miRTarBase miRNAs that target ENPP4:
    hsa-mir-192-5p (MIRT026249), hsa-mir-16-5p (MIRT031579), hsa-mir-103a-3p (MIRT027007), hsa-mir-215-5p (MIRT024537)

    Block miRNA regulation of human, mouse, rat ENPP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ENPP4 (see all 32):
    hsa-miR-579 hsa-miR-3685 hsa-miR-24-1* hsa-miR-301a hsa-miR-519a hsa-miR-3171 hsa-miR-183* hsa-miR-124
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ENPP4
    Predesigned siRNA for gene silencing in human, mouse, rat ENPP4

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ENPP4

    Clone
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    OriGene ORF clones in mouse, rat for ENPP4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ENPP4 (NM_014936)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENPP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENPP4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ENPP4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENPP4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ENPP4_HUMAN, Q9Y6X5: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    peroxisome2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with ENPP4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ENPP4
    Interactions:

        Search GeneGlobe Interaction Network for ENPP4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ENPP4 (ENSP000003180664) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIGMAR1ENSP000002770104STRING: ENSP00000277010
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation IEA--
    GO:0008152metabolic process ----
    GO:0030194positive regulation of blood coagulation IDA--
    GO:0046130purine ribonucleoside catabolic process IDA--

    Find genes that share ontologies with ENPP4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ENPP4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ENPP4 gene: 
    NM_014936.4  

    Unigene Cluster for ENPP4:

    Ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
    Hs.643497  [show with all ESTs]
    Unigene Representative Sequence: NM_014936
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000321037(uc003oxy.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat ENPP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ENPP4 (see all 32):
    hsa-miR-579 hsa-miR-3685 hsa-miR-24-1* hsa-miR-301a hsa-miR-519a hsa-miR-3171 hsa-miR-183* hsa-miR-124
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ENPP4
    Predesigned siRNA for gene silencing in human, mouse, rat ENPP4
    Clone
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    OriGene clones in human, mouse for ENPP4 (see all 7)
    OriGene ORF clones in mouse, rat for ENPP4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ENPP4 (NM_014936)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENPP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENPP4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ENPP4
    OriGene qSTAR qPCR primer pairs in human, mouse for ENPP4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ENPP4
      QuantiTect SYBR Green Assays in human, mouse, rat ENPP4
      Search QuantiFast Probe-based Assays in human, mouse, rat ENPP4

    Additional mRNA sequence: 

    AB020686.1 AJ420515.1 AK291276.1 BC018054.1 

    3 DOTS entries:

    DT.314485  DT.95298965  DT.121319420 

    Selected AceView cDNA sequences (see all 122):

    BG656458 AI520733 AI890958 BM986807 AI474880 AW089437 AI923781 BI020429 
    AW304705 AA281112 BI467324 W32322 AA716267 AA281210 AW572074 AL708571 
    AA569130 AW628034 AW473562 AB020686 AI889993 AW270089 AI571059 AA811403 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ENPP4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4
    SP1:              -                           
    SP2:                                          


    ECgene alternative splicing isoforms for ENPP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ENPP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTTAAAA
    ENPP4 Expression
    About this image


    ENPP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Conventional Dendritic Cells I Spleen
     
     Gonad
             Primordial Germ Cells Allantois
     
     Placenta (Extraembryonic Tissues)
             Primordial Germ Cells Allantois
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    ENPP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ENPP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643497

    UniProtKB/Swiss-Prot: ENPP4_HUMAN, Q9Y6X5
    Tissue specificity: Expressed on the surface of vascular endothelia

        Custom PCR Arrays for ENPP4
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    Search QuantiFast Probe-based Assays in human, mouse, rat ENPP4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENPP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ENPP4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Enpp41 , 5 ectonucleotide pyrophosphatase/phosphodiesterase 41, 5 84(n)1
    82.52(a)1
      17 (20.34 cM)5
    2247941  NM_199016.21  NP_950181.21 
     440963085 
    chicken
    (Gallus gallus)
    Aves ENPP41 ectonucleotide pyrophosphatase/phosphodiesterase 4 more 68.09(n)
    65.65(a)
      422055  NM_001006422.1  NP_001006422.1 
    lizard
    (Anolis carolinensis)
    Reptilia ENPP46
    ectonucleotide pyrophosphatase/phosphodiesterase 4...
    72(a)
    1 ↔ 1
    1(138637671-138643392)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.33572 Xenopus laevis transcribed sequence with weak similarity more 78.49(n)    48053842 
    zebrafish
    (Danio rerio)
    Actinopterygii enpp41 ectonucleotide pyrophosphatase/phosphodiesterase 4 60.82(n)
    58.43(a)
      550586  NM_001017887.1  NP_001017887.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C01B10.93
    CELE_C01B10.91
    CELE_C01B10.91 30(a)3
    46.07(n)1
    33.41(a)1
      IV(6632384-6633565)3
    1774301  NM_068622.51  NP_501023.31 


    ENSEMBL Gene Tree for ENPP4 (if available)
    TreeFam Gene Tree for ENPP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ENPP4 gene
    ENPP62  ENPP32  ENPP12  ENPP52  ENPP72  ENPP22  
    6 SIMAP similar genes for ENPP4 using alignment to 2 protein entries:     ENPP4_HUMAN (see all proteins):
    ENPP5    ENPP3    ENPP1    ENPP6    ENPP7    ENPP2

    Find genes that share paralogs with ENPP4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ENPP4 (see all 396)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1157008381,2
    F--46095741(+) AAATCG/ATTGAG 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs737357081,2
    C,F--46095758(+) ACTCAA/TCCAGT 1 -- us2k12Minor allele frequency- T:0.04WA 120
    rs37568021,2
    C,F,A,H--46095836(+) TTTTGG/ATTGTG 1 -- us2k1 tfbs314Minor allele frequency- A:0.43NS EA NA WA CSA 768
    rs1456194931,2
    --46095864(+) ATAGAA/GGATAA 1 -- us2k10--------
    rs93695991,2
    C,F,A--46095892(+) AGGTCC/TTTATG 1 -- us2k1 tfbs313Minor allele frequency- T:0.43NA WA CSA EA 514
    rs1157701141,2
    C,F--46095925(+) TGACCA/GCTTTA 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1482813711,2
    C--46096012(+) GAGAGA/TCCTCT 1 -- us2k10--------
    rs109482821,2
    C,F--46096018(+) CCTCTC/TCTGAT 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs37568031,2
    C,F,A,H--46096038(+) GCTGCT/CATCTT 1 -- us2k1 tfbs317Minor allele frequency- C:0.42NA EA WA CSA 868
    rs1826421131,2
    --46096349(+) GAGGTC/TGGTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ENPP4 (46097701 - 46114436 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ENPP4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ENPP4
    DNA2.0 Custom Variant and Variant Library Synthesis for ENPP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ENPP4           About GenesLikeMe

    Genetic Association Database (GAD): ENPP4

    Export disorders for ENPP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ENPP4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ENPP4)
        Utopia: connect your pdf to the dynamic
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    1. Structural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatases. (PubMed id 11027689)1, 2, 3 Gijsbers R.... Bollen M. (J. Biol. Chem. 2001)
    2. NPP4 is a procoagulant enzyme on the surface of vascular endothelium. (PubMed id 22995898)1, 2 Albright R.A.... Braddock D.T. (Blood 2012)
    3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    4. The molecular basis of purinergic signal metabolism by ecto- nucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke. (PubMed id 24338010)2 Albright R.A.... Braddock D.T. (J. Biol. Chem. 2013)
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22875 HGNC: 3359 AceView: ENPP4 Ensembl:ENSG00000001561 euGenes: HUgn22875
    ECgene: ENPP4 H-InvDB: ENPP4

    (According to HUGE)
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    HUGE: KIAA0879

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ENPP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ENPP4 gene:
    Search GeneIP for patents involving ENPP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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