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Aliases for ENPP3 Gene

Aliases for ENPP3 Gene

  • Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 2 3
  • PDNP3 3 4 6
  • Phosphodiesterase I/Nucleotide Pyrophosphatase 3 3 4
  • PD-IBETA 3 4
  • Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 3
  • DJ1005H11.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3) 3
  • DJ914N13.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3) 3
  • Phosphodiesterase-I Beta 3
  • Phosphodiesterase I Beta 4
  • CD203c Antigen 4
  • Gp130RB13-6 3
  • E-NPP 3 4
  • CD203c 3
  • NPP3 3
  • B10 3

External Ids for ENPP3 Gene

Previous Symbols for ENPP3 Gene

  • PDNP3

Summaries for ENPP3 Gene

Entrez Gene Summary for ENPP3 Gene

  • The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for ENPP3 Gene

ENPP3 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 3) is a Protein Coding gene. Diseases associated with ENPP3 include sm-ahnmd and bile duct disease. Among its related pathways are Metabolism and Nicotinate and nicotinamide metabolism. GO annotations related to this gene include nucleic acid binding and polysaccharide binding. An important paralog of this gene is ENPP1.

UniProtKB/Swiss-Prot for ENPP3 Gene

  • Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD.

Gene Wiki entry for ENPP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENPP3 Gene

Genomics for ENPP3 Gene

Genomic Location for ENPP3 Gene

Start:
131,628,442 bp from pter
End:
131,747,418 bp from pter
Size:
118,977 bases
Orientation:
Plus strand

Genomic View for ENPP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ENPP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENPP3 Gene

Regulatory Elements for ENPP3 Gene

Proteins for ENPP3 Gene

  • Protein details for ENPP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14638-ENPP3_HUMAN
    Recommended name:
    Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
    Protein Accession:
    O14638
    Secondary Accessions:
    • Q5JTL3

    Protein attributes for ENPP3 Gene

    Size:
    875 amino acids
    Molecular mass:
    100124 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD05192.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ENPP3 Gene

Proteomics data for ENPP3 Gene at MOPED

Post-translational modifications for ENPP3 Gene

  • N-glycosylation is necessary for correct trafficking to the apical surface, but is not the apical targeting signal.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn236, Asn279, Asn290, Asn426, Asn533, Asn582, Asn594, Asn687, Asn699, and Asn789

Other Protein References for ENPP3 Gene

No data available for DME Specific Peptides for ENPP3 Gene

Domains for ENPP3 Gene

Gene Families for ENPP3 Gene

HGNC:
  • CD :CD molecules

UniProtKB/Swiss-Prot:

ENPP3_HUMAN
Domain:
  • Contains 2 SMB (somatomedin-B) domains.:
    • O14638
Family:
  • Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.:
    • O14638
genes like me logo Genes that share domains with ENPP3: view

Function for ENPP3 Gene

Molecular function for ENPP3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Hydrolytically removes 5-nucleotides successively from the 3-hydroxy termini of 3-hydroxy-terminated oligonucleotides
UniProtKB/Swiss-Prot CatalyticActivity: A dinucleotide + H(2)O = 2 mononucleotides
UniProtKB/Swiss-Prot EnzymeRegulation: At low concentrations of ATP, a phosphorylated active site intermediate is formed which inhibits further ATP hydrolysis
UniProtKB/Swiss-Prot Function: Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD.
UniProtKB/Swiss-Prot Induction: Up-regulated by stimulation by allergen or by cross-linking with IgE. The IgE-mediated activation is enhanced by tetradecanoyl phorbol acetate (TPA), a stimulator of the PKC pathway, and inhibited by the P13 kinase inhibitors, LY294002 and wortmannin. Up-regulated in invasive bile duct cancers.

Gene Ontology (GO) - Molecular Function for ENPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003824 catalytic activity --
GO:0004528 phosphodiesterase I activity IEA --
GO:0004551 nucleotide diphosphatase activity TAS 9344668
GO:0005044 scavenger receptor activity IEA --
genes like me logo Genes that share ontologies with ENPP3: view

Phenotypes for ENPP3 Gene

GenomeRNAi human phenotypes for ENPP3:
genes like me logo Genes that share phenotypes with ENPP3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ENPP3 Gene

Localization for ENPP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENPP3 Gene

Membrane; Single-pass type II membrane protein. Secreted. Note=Located to the apical surface in intestinal and kidney epithelial cells. Located to the cell surface of basophils, and to the apical plasma membrane of bile duct cells. Secreted in serum, and in lumen of epithelial cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ENPP3 Gene COMPARTMENTS Subcellular localization image for ENPP3 gene
Compartment Confidence
extracellular 5
plasma membrane 4
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ENPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9344668
GO:0048471 perinuclear region of cytoplasm IDA 10513816
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ENPP3: view

Pathways for ENPP3 Gene

genes like me logo Genes that share pathways with ENPP3: view

Pathways by source for ENPP3 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for ENPP3 Gene

Interacting Proteins for ENPP3 Gene

Gene Ontology (GO) - Biological Process for ENPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process IDA 10513816
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006955 immune response IEA --
GO:0008152 metabolic process --
GO:0009143 nucleoside triphosphate catabolic process IDA 10513816
genes like me logo Genes that share ontologies with ENPP3: view

Compounds for ENPP3 Gene

(17) HMDB Compounds for ENPP3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Adenosine monophosphate
  • 5'-AMP
61-19-8
Dephospho-CoA
  • 3'-O-dephosphono-Coenzyme A
3633-59-8
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Flavin Mononucleotide
  • FMN
146-17-8

(3) Novoseek inferred chemical compound relationships for ENPP3 Gene

Compound -log(P) Hits PubMed IDs
histamine 65.1 16
allergens 55.5 6
wortmannin 39.1 1
genes like me logo Genes that share compounds with ENPP3: view

Transcripts for ENPP3 Gene

Unigene Clusters for ENPP3 Gene

Ectonucleotide pyrophosphatase/phosphodiesterase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ENPP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: - - -
SP2: - - - -
SP3: -
SP4: -

ExUns: 26 ^ 27 ^ 28a · 28b
SP1:
SP2:
SP3:
SP4:

Relevant External Links for ENPP3 Gene

GeneLoc Exon Structure for
ENPP3
ECgene alternative splicing isoforms for
ENPP3

Expression for ENPP3 Gene

mRNA expression in normal human tissues for ENPP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENPP3 Gene

This gene is overexpressed in Minor Salivary Gland (6.9), Colon - Transverse (6.1), and Adrenal Gland (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ENPP3 Gene

SOURCE GeneReport for Unigene cluster for ENPP3 Gene Hs.486489

mRNA Expression by UniProt/SwissProt for ENPP3 Gene

O14638-ENPP3_HUMAN
Tissue specificity: Expressed in bile ducts, prostate, uterus and colon. Exclusively expressed on basophils, mast cells and their progenitors.
genes like me logo Genes that share expressions with ENPP3: view

Orthologs for ENPP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ENPP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ENPP3 36
  • 99.54 (n)
  • 99.31 (a)
ENPP3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ENPP3 36
  • 85.96 (n)
  • 81.92 (a)
ENPP3 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ENPP3 36
  • 86.96 (n)
  • 85.24 (a)
ENPP3 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Enpp3 36
  • 82.02 (n)
  • 80.99 (a)
Enpp3 16
Enpp3 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ENPP3 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 50 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
-- 37
  • 57 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Enpp3 36
  • 81.58 (n)
  • 81.58 (a)
chicken
(Gallus gallus)
Aves ENPP3 36
  • 68.84 (n)
  • 66.82 (a)
ENPP3 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ENPP3 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia enpp3 36
  • 65.2 (n)
  • 63.28 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01103847.1 37
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F13H10.5 37
  • 20 (a)
OneToMany
C27A7.3 38
  • 31 (a)
C27A7.1 38
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPP1 37
  • 20 (a)
ManyToMany
NPP2 37
  • 25 (a)
ManyToMany
NPP2 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G29700 36
  • 51.75 (n)
  • 42.82 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2772 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToMany
Species with no ortholog for ENPP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENPP3 Gene

ENSEMBL:
Gene Tree for ENPP3 (if available)
TreeFam:
Gene Tree for ENPP3 (if available)

Paralogs for ENPP3 Gene

Paralogs for ENPP3 Gene

Selected SIMAP similar genes for ENPP3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ENPP3: view

Variants for ENPP3 Gene

Sequence variations from dbSNP and Humsavar for ENPP3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs364964 -- 131,692,716(-) atata(A/C)tatat intron-variant
rs365475 -- 131,734,481(-) CTTTC(A/G)TTAAA intron-variant
rs378697 -- 131,722,209(-) AAAAT(A/T)AGTTC intron-variant
rs404179 -- 131,718,748(-) AAAGC(A/C)GTAAG intron-variant
rs449441 -- 131,720,743(+) GGCCC(A/G)GCTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENPP3 Gene

Variant ID Type Subtype PubMed ID
nsv7968 CNV Loss 18304495
dgv88n68 CNV Loss 17160897
nsv886669 CNV Gain 21882294
esv24430 CNV Gain+Loss 19812545
nsv821228 CNV Duplication 20802225
nsv471444 CNV Duplication 19718026
esv2637208 CNV Insertion 19546169
esv1329374 CNV Insertion 17803354

Relevant External Links for ENPP3 Gene

HapMap Linkage Disequilibrium report
ENPP3

Disorders for ENPP3 Gene

(2) MalaCards Diseases for ENPP3 Gene

Search for ENPP3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ENPP3 Gene

(5) Novoseek inferred disease relationships for ENPP3 Gene

Disease -log(P) Hits PubMed IDs
idiopathic urticaria 74.4 4
allergy 60.5 16
anaphylaxis 33.6 2
tumors 0 3
cancer 0 3

Relevant External Links for ENPP3

Genetic Association Database (GAD)
ENPP3
Human Genome Epidemiology (HuGE) Navigator
ENPP3
genes like me logo Genes that share disorders with ENPP3: view

No data available for UniProtKB/Swiss-Prot for ENPP3 Gene

Publications for ENPP3 Gene

  1. Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes. (PMID: 9344668) Piao J.-H. … Sano K. (Genomics 1997) 2 3 4 23
  2. The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3. (PMID: 11342463) Buehring H.J. … Sano K. (Blood 2001) 3 4 23
  3. The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis. (PMID: 15031605) Buehring H.J. … Valent P. (Int. Arch. Allergy Immunol. 2004) 3 4 23
  4. Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-1 (E-NPP1/PC-1) and -3 (E- NPP3/CD203c/PD-Ibeta/B10/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases. (PMID: 15072822) Yano Y. … Kasuga M. (Cancer Lett. 2004) 3 4 23
  5. Flow cytometry for basophil activation markers: the measurement of CD203c up-regulation is as reliable as CD63 expression in the diagnosis of cat allergy. (PMID: 17275019) Ocmant A. … SchandenAc L. (J. Immunol. Methods 2007) 3 23

Products for ENPP3 Gene

Sources for ENPP3 Gene

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