Aliases for ENPP2 Gene
External Ids for ENPP2 Gene
Previous HGNC Symbols for ENPP2 Gene
Previous GeneCards Identifiers for ENPP2 Gene
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]
GeneCards Summary for ENPP2 Gene
ENPP2 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) is a Protein Coding gene. Diseases associated with ENPP2 include intrahepatic cholestasis and obesity. Among its related pathways are NAD metabolism and Acyl chain remodelling of PC. GO annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is ENPP3.
UniProtKB/Swiss-Prot for ENPP2 Gene
Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.
Autotaxin (also known as nucleotide pyrophosphatase-phosphodiesterase 2, NPP2) is a secreted enzyme with lysophospholipase D activity and is the primary enzyme responsible for generating lysophosphatidic acid (LPA).