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ENPEP Gene

protein-coding   GIFtS: 68
GCID: GC04P111286

Glutamyl Aminopeptidase (Aminopeptidase A)

  See ENPEP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glutamyl Aminopeptidase (Aminopeptidase A)1 2     APA2
Aminopeptidase A2 3     CD2492
Differentiation Antigen Gp1602 3     Glutamyl Aminopeptidase2
AP-A2 3     gp1602
EAP2 3     CD249 Antigen3
EC 3.4.11.73 8     EC 3.4.118

External Ids:    HGNC: 33551   Entrez Gene: 20282   Ensembl: ENSG000001387927   OMIM: 1382975   UniProtKB: Q070753   

Export aliases for ENPEP gene to outside databases

Previous GC identifers: GC04P111803 GC04P111679 GC04P111856 GC04P111754 GC04P111397 GC04P107128


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ENPEP Gene:
ENPEP (glutamyl aminopeptidase (aminopeptidase A)) is a protein-coding gene. Diseases associated with ENPEP include neurogenic hypertension, and gestational choriocarcinoma. GO annotations related to this gene include metalloaminopeptidase activity and aminopeptidase activity. An important paralog of this gene is LNPEP.

UniProtKB/Swiss-Prot: AMPE_HUMAN, Q07075
Function: Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role
in regulating growth and differentiation of early B-lineage cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ENPEP gene promoter:
         GR   FOXF2   FOXD3   NF-AT   HNF-1A   NF-AT4   NF-AT2   HNF-1   GR-alpha   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidENPEP promoter sequence
   Search Chromatin IP Primers for ENPEP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ENPEP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

ENPEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ENPEP gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P111286:  view genomic region     (about GC identifiers)

Start:
111,286,889 bp from pter      End:
111,486,441 bp from pter
Size:
199,553 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AMPE_HUMAN, Q07075 (See protein sequence)
Recommended Name: Glutamyl aminopeptidase  
Size: 957 amino acids; 109244 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homodimer; disulfide-linked
Selected PDB 3D structures from and Proteopedia for ENPEP (see all 7):
4KX7 (3D)        4KX8 (3D)        4KX9 (3D)        4KXA (3D)        4KXB (3D)        4KXC (3D)    
Secondary accessions: Q504U2

Explore the universe of human proteins at neXtProt for ENPEP: NX_Q07075

Explore proteomics data for ENPEP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn124, Asn197, Asn324, Asn340, Asn554, Asn589, Asn597, Asn607, Asn678, Asn763,
                                 Asn773, Asn801, Asn828
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ENPEP (Q07075) (see all 17)
     WLNEGFA  GFYRVNY  GAMENWG  NAKTSDFW 


    See ENPEP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001968.3  
    ENSEMBL proteins: 
     ENSP00000265162   ENSP00000426265  
    Reactome Protein details: Q07075

    ENPEP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ENPEP (Aminopeptidase A/ENPEP)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ENPEP
    OriGene Protein Over-expression Lysate for ENPEP
    OriGene MassSpec for ENPEP
    OriGene Custom Protein Services for ENPEP
    GenScript Custom Purified and Recombinant Proteins Services for ENPEP
    Novus Biologicals ENPEP Lysate
    Sino Biological Recombinant Protein for ENPEP
    Sino Biological Cell Lysate for ENPEP
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ENPEP 

     
    antibodies-online proteins for ENPEP (2 products) 

     
    antibodies-online peptides for ENPEP

    ENPEP Antibody Products:

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    Novus Biologicals ENPEP Antibodies
    Abcam antibodies for ENPEP
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for ENPEP
    antibodies-online antibodies for ENPEP (68 products) 

    ENPEP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ENPEP
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ENPEP 
    antibodies-online kits for ENPEP (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: Glutamyl aminopeptidase
    Aminopeptidases

    3 InterPro protein domains:
     IPR014782 Peptidase_M1_N
     IPR024571 ERAP1-like_C_dom
     IPR001930 Peptidase_M1

    Graphical View of Domain Structure for InterPro Entry Q07075

    ProtoNet protein and cluster: Q07075

    1 Blocks protein domain: IPB001930 Membrane alanyl dipeptidase (M1) family signature

    UniProtKB/Swiss-Prot: AMPE_HUMAN, Q07075
    Similarity: Belongs to the peptidase M1 family


    Find genes that share domains with ENPEP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMPE_HUMAN, Q07075
    Function: Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role
    in regulating growth and differentiation of early B-lineage cells
    Catalytic activity: Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide

         Genatlas biochemistry entry for ENPEP:
    glutamyl aminopeptidase,homolog of murine B-lymphocyte differentiation antigen BP-1/6C3

         Enzyme Numbers (IUBMB): EC 3.4.11.71 2 EC 3.4.112

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IDA8244382
    GO:0008233peptidase activity ----
    GO:0008237metallopeptidase activity EXP--
    GO:0008270zinc ion binding IEA--
    GO:0070006metalloaminopeptidase activity NAS8244382
         
    Find genes that share ontologies with ENPEP           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Enpep):
     immune system 

    Find genes that share phenotypes with ENPEP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Enpeptm1Mdc for ENPEP

       genOway: Develop your customized and physiologically relevant rodent model for ENPEP

    miRNA
    Products:
        
    miRTarBase miRNAs that target ENPEP:
    hsa-mir-320a (MIRT044621)

    Block miRNA regulation of human, mouse, rat ENPEP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ENPEP (see all 50):
    hsa-miR-548j hsa-miR-376b hsa-miR-548k hsa-miR-513a-5p hsa-miR-548l hsa-miR-9 hsa-miR-133a hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidENPEP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ENPEP
    Predesigned siRNA for gene silencing in human, mouse, rat ENPEP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ENPEP

    Clone
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    OriGene clones in human, mouse for ENPEP (see all 7)
    OriGene ORF clones in mouse, rat for ENPEP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ENPEP (NM_001977)
    Sino Biological Human cDNA Clone for ENPEP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENPEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENPEP

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ENPEP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENPEP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AMPE_HUMAN, Q07075: Membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS8244382
    GO:0005903brush border ISS--
    GO:0009897external side of plasma membrane ISS--

    Find genes that share ontologies with ENPEP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ENPEP About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Metabolism of Angiotensinogen to Angiotensins0.00
    2Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Renin-angiotensin system0.37
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with ENPEP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for ENPEP
        Metabolism of Angiotensinogen to Angiotensins


    1 Kegg Pathway  (Kegg details for ENPEP):
        Renin-angiotensin system

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ENPEP
    Interactions:

        GeneGlobe Interaction Network for ENPEP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for ENPEP (Q070753 ENSP000002651624) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGTP010193, ENSP000003556274I2D: score=1 STRING: ENSP00000355627
    CCKP063073, ENSP000003356574I2D: score=1 STRING: ENSP00000335657
    ATP6AP2ENSP000003676974STRING: ENSP00000367697
    ORC2ENSP000002342964STRING: ENSP00000234296
    OXLD1ENSP000003638734STRING: ENSP00000363873
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ISS--
    GO:0002003angiotensin maturation TAS--
    GO:0002005angiotensin catabolic process in blood NAS19608358
    GO:0003081regulation of systemic arterial blood pressure by renin-angiotensin NAS8346219
    GO:0006508proteolysis ----

    Find genes that share ontologies with ENPEP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ENPEP
      Browse compounds at ApexBio 

    Browse Tocris compounds for ENPEP (AMPE)

    2 HMDB Compounds for ENPEP    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ZincZinc (see all 2)7440-66-6--

    1 DrugBank Compound for ENPEP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--7448199 11732752 17139284 17016423 8568030

    Selected Novoseek inferred chemical compound relationships for ENPEP gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amastatin 89.8 15 8004400 (2), 10692253 (1), 12612435 (1), 2331601 (1) (see all 11)
    bestatin 65.7 2 2227802 (1)
    ang ii 63.9 11 11994381 (3), 10557335 (2), 15187414 (1), 15507845 (1)
    leucine 47.5 20 12614948 (2), 16769060 (2), 12361682 (2), 12685816 (2) (see all 10)
    losartan 40 3 10985964 (1), 18293706 (1)
    zinc 35.2 11 14674752 (1), 10653662 (1), 8550619 (1), 11724556 (1) (see all 9)
    aspartate 30.2 9 18726831 (1), 1982017 (1), 9681597 (1), 7909847 (1)
    glutamate 22.4 9 12685816 (1), 11724556 (1), 20023072 (1), 1982017 (1) (see all 6)
    sodium 16.9 6 8781481 (2), 8277502 (1), 7920260 (1), 1376904 (1)
    arginine 12.4 4 12685816 (1), 12361682 (1), 11732752 (1)



    Find genes that share compounds with ENPEP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ENPEP gene: 
    NM_001977.3  

    Unigene Cluster for ENPEP:

    Glutamyl aminopeptidase (aminopeptidase A)
    Hs.435765  [show with all ESTs]
    Unigene Representative Sequence: NM_001977
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510961 ENST00000265162(uc003iab.4) ENST00000509344 ENST00000502711
    ENST00000504100
    miRNA
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    Block miRNA regulation of human, mouse, rat ENPEP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ENPEP (see all 50):
    hsa-miR-548j hsa-miR-376b hsa-miR-548k hsa-miR-513a-5p hsa-miR-548l hsa-miR-9 hsa-miR-133a hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidENPEP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ENPEP
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ENPEP (NM_001977)
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ENPEP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ENPEP
      QuantiTect SYBR Green Assays in human, mouse, rat ENPEP
      QuantiFast Probe-based Assays in human, mouse, rat ENPEP

    Additional mRNA sequence: 

    AK313412.1 AM888273.1 AM888274.1 AM888275.1 AM888276.1 AM888277.1 AM888278.1 AM888279.1 
    AM888280.1 AM888281.1 AM888282.1 AM888283.1 BC094770.1 BX641012.1 L12468.1 L14721.1 

    9 DOTS entries:

    DT.212653  DT.92427418  DT.121249716  DT.121249721  DT.75140787  DT.92427419  DT.92427420  DT.102828585 
    DT.75182340 

    Selected AceView cDNA sequences (see all 125):

    AA873549 AL548997 AU139354 BG413393 BG219862 AW139905 AA778054 AI670907 
    AL709252 AL541184 NM_001977 BU753576 AI288822 BG431081 BX641012 AW000915 
    BG400415 AW451569 BG166498 AI935775 AU100285 CF593778 AI307818 AI640493 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ENPEP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGGAATT
    ENPEP Expression
    About this image


    ENPEP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Kidney (Urinary System)    fully expand to see all 7 entries
             Proximal Tubule Cells Proximal Tubule
             Metanephros
             Adult human kidney epithelial cells
     
     Epithelial Cells
             Proximal Tubule Cells Proximal Tubule
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Testicular Interstitial Cells Testis Interstitium
             Testis Interstitium
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
    ENPEP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ENPEP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435765

    UniProtKB/Swiss-Prot: AMPE_HUMAN, Q07075
    Tissue specificity: Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron.
    Also found in a variety of other tissues

        Custom PCR Arrays for ENPEP
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    QuantiFast Probe-based Assays in human, mouse, rat ENPEP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENPEP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ENPEP gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Enpep1 , 5 glutamyl aminopeptidase1, 5 80.47(n)1
    78.6(a)1
      3 (57.92 cM)5
    138091  NM_007934.31  NP_031960.11 
     1292691755 
    chicken
    (Gallus gallus)
    Aves ENPEP1 glutamyl aminopeptidase (aminopeptidase A) 69.7(n)
    68.42(a)
      428771  XM_426327.3  XP_426327.3 
    lizard
    (Anolis carolinensis)
    Reptilia ENPEP6
    glutamyl aminopeptidase (aminopeptidase A)
    63(a)
    1 ↔ 1
    5(144017983-144065792)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia enpep1 glutamyl aminopeptidase (aminopeptidase A) 64.88(n)
    61.51(a)
      100494326  XM_002934249.2  XP_002934295.1 
    zebrafish
    (Danio rerio)
    Actinopterygii enpep1 glutamyl aminopeptidase 62.29(n)
    60.04(a)
      504088  NM_001199731.1  NP_001186660.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG87733
    CG324731
    glutamyl aminopeptidase3
    CG324731
    37(a)
    (best of 10)3
    49.56(n)1
    41.26(a)1
      87E43
    416361  NM_169503.31  NP_731786.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y67D8C.93   -- 32(a)
    (best of 7)
      IV(3077664-3086852)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AAP16
    APE26
    Arginine/alanine aminopeptidase, overproduction st...
    Aminopeptidase yscII; may have a role in obtaining...
    31(a)
    29(a)
    many ↔ many
    many ↔ many
    VIII(198740-201310) YHR047C
    XI(154991-158232) YKL157W


    ENSEMBL Gene Tree for ENPEP (if available)
    TreeFam Gene Tree for ENPEP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ENPEP gene
    LNPEP2  TRHDE2  ANPEP2  LOC1010602122  ERAP12  NPEPPS2  AQPEP2  ERAP22  
    10 SIMAP similar genes for ENPEP using alignment to 14 protein entries:     AMPE_HUMAN (see all proteins):
    LOC100510707    NPEPPSL1    ANPEP    ERAP2    ERAP1    NPEPPS
    TRHDE    LNPEP    AQPEP    FLJ90650

    Find genes that share paralogs with ENPEP           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ENPEP
    PGOHUM00000242698 PGOHUM00000233313


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ENPEP (see all 1725)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360474
    A breast cancer sample4--see VAR_0360472 R T mis40--------
    rs1839426191,2
    --111395288(+) GTTTAA/TCATAA 1 -- us2k10--------
    rs65335221,2
    C,F,H--111395523(+) TTAGGA/GTTGCT 1 -- us2k113Minor allele frequency- G:0.10NA WA CSA EA 377
    rs1884261501,2
    --111395590(+) CTTTTC/TCCTTT 1 -- us2k10--------
    rs1931679671,2
    --111395718(+) GAACCA/GTTTGA 1 -- us2k10--------
    rs37759591,2
    C,F,H--111395839(-) GCCTCC/TCAGAG 1 -- us2k123Minor allele frequency- T:0.11NS EA NA WA CSA 2173
    rs1850021081,2
    --111395971(+) CTGGGG/TAAATA 1 -- us2k10--------
    rs1430506641,2
    --111396016(+) TTATCC/TTCCTC 1 -- us2k10--------
    rs1512155971,2
    C--111396053(+) CGATCA/GTTGAT 1 -- us2k10--------
    rs1423855741,2
    C--111396069(+) ACTTT-/AAATTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ENPEP (111286889 - 111486441 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ENPEP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507187CNV Insertion20534489
    nsv518506CNV Loss19592680
    nsv830036CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ENPEP
    DNA2.0 Custom Variant and Variant Library Synthesis for ENPEP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138297    OMIM disorders: --

    3 diseases for ENPEP:    
    About MalaCards
    neurogenic hypertension    gestational choriocarcinoma    choriocarcinoma

    2 diseases from the University of Copenhagen DISEASES database for ENPEP:
    Hypertension     Antiphospholipid syndrome

    Find genes that share disorders with ENPEP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ENPEP gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 43.3 12 10692253 (5), 12915695 (3), 11718570 (1)
    systemic hypertension 36.3 1 18206321 (1)
    preeclampsia 34.8 2 15893965 (1), 10985964 (1)
    neoplastic transformation 32.9 5 10838501 (4)
    renal cancer 32.6 2 16985214 (1), 9664120 (1)
    glomerulosclerosis 29.9 4 18206321 (2)
    carcinoma renal cell 24.1 2 9486416 (1), 8346219 (1)
    cervical intraepithelial neoplasia 19.2 2 15048132 (1)
    neovascularization 5.3 2 8869294 (2)
    carcinoma squamous cell 0 2 15048132 (1)

    Genetic Association Database (GAD): ENPEP
    Human Genome Epidemiology (HuGE) Navigator: ENPEP (3 documents)

    Export disorders for ENPEP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ENPEP gene, integrated from 10 sources (see all 150):
    (articles sorted by number of sources associating them with ENPEP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human kidney differentiation antigen gp160: human aminopeptidase A. (PubMed id 8346219)1, 2, 9 Nanus D.M.... Albino A.P. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    2. cDNA cloning and expression of human glutamyl aminopeptidase (aminopeptidase A). (PubMed id 8244382)1, 2, 9 Li L.... Cooper M.D. (Genomics 1993)
    3. High-resolution genetic map of the human glutamyl aminopeptidase gene (ENPEP). (PubMed id 9268642)1, 3, 9 Li L....Cooper M.D. (Genomics 1997)
    4. Functional genetic variation in aminopeptidase A (ENPEP): lack of clear association with focal and segmental glomerulosclerosis (FSGS). (PubMed id 18206321)1, 4, 9 Tonna S....Pollak M.R. (Gene 2008)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    7. Variants conferring risk of atrial fibrillation on chromosome 4q25. (PubMed id 17603472)1, 4 Gudbjartsson D.F....Stefansson K. (Nature 2007)
    8. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Regulation of aminopeptidase A expression in cervical carcinoma: role of tumor-stromal interaction and vascular endothelial growth factor. (PubMed id 15048132)1, 9 Suganuma T....Mizutani S. ( a journal of technical methods and pathology 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2028 HGNC: 3355 AceView: ENPEP Ensembl:ENSG00000138792 euGenes: HUgn2028
    ECgene: ENPEP Kegg: 2028 H-InvDB: ENPEP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ENPEP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ENPEP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ENPEP gene:
    Search GeneIP for patents involving ENPEP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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