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Aliases for ENPEP Gene

Aliases for ENPEP Gene

  • Glutamyl Aminopeptidase (Aminopeptidase A) 2 3
  • Differentiation Antigen Gp160 3 4
  • Aminopeptidase A 3 4
  • EC 4 63
  • AP-A 3 4
  • EAP 3 4
  • CD249 Antigen 4
  • EC 3.4.11 63
  • CD249 3
  • Gp160 3
  • APA 3

External Ids for ENPEP Gene

Previous GeneCards Identifiers for ENPEP Gene

  • GC04P111803
  • GC04P111679
  • GC04P111856
  • GC04P111754
  • GC04P111397
  • GC04P111286
  • GC04P107128

Summaries for ENPEP Gene

GeneCards Summary for ENPEP Gene

ENPEP (Glutamyl Aminopeptidase (Aminopeptidase A)) is a Protein Coding gene. Diseases associated with ENPEP include neurogenic hypertension and syphilitic meningitis. Among its related pathways are Transport to the Golgi and subsequent modification and Peptide hormone metabolism. GO annotations related to this gene include peptidase activity and aminopeptidase activity. An important paralog of this gene is ERAP1.

UniProtKB/Swiss-Prot for ENPEP Gene

  • Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENPEP Gene

Genomics for ENPEP Gene

Regulatory Elements for ENPEP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ENPEP Gene

110,365,733 bp from pter
110,565,285 bp from pter
199,553 bases
Plus strand

Genomic View for ENPEP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for ENPEP Gene

Proteins for ENPEP Gene

  • Protein details for ENPEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutamyl aminopeptidase
    Protein Accession:
    Secondary Accessions:
    • Q504U2

    Protein attributes for ENPEP Gene

    957 amino acids
    Molecular mass:
    109244 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Homodimer; disulfide-linked

    Three dimensional structures from OCA and Proteopedia for ENPEP Gene

neXtProt entry for ENPEP Gene

Proteomics data for ENPEP Gene at MOPED

Post-translational modifications for ENPEP Gene

  • Glycosylation at Asn 124, Asn 197, Asn 324, Asn 340, Asn 554, Asn 589, Asn 597, Asn 607, Asn 678, Asn 763, Asn 773, Asn 801, and Asn 828
  • Modification sites at PhosphoSitePlus

Other Protein References for ENPEP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ENPEP (Aminopeptidase A/ENPEP)
  • Cloud-Clone Corp. Antibodies for ENPEP

Domains & Families for ENPEP Gene

Gene Families for ENPEP Gene

Protein Domains for ENPEP Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M1 family.
  • Belongs to the peptidase M1 family.
genes like me logo Genes that share domains with ENPEP: view

Function for ENPEP Gene

Molecular function for ENPEP Gene

GENATLAS Biochemistry:
glutamyl aminopeptidase,homolog of murine B-lymphocyte differentiation antigen BP-1/6C3
UniProtKB/Swiss-Prot CatalyticActivity:
Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide
UniProtKB/Swiss-Prot Function:
Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells

Enzyme Numbers (IUBMB) for ENPEP Gene

Gene Ontology (GO) - Molecular Function for ENPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IDA 8244382
GO:0008233 peptidase activity --
GO:0008237 metallopeptidase activity EXP --
GO:0008270 zinc ion binding IBA --
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with ENPEP: view

Phenotypes for ENPEP Gene

MGI mutant phenotypes for ENPEP:
inferred from 1 alleles
GenomeRNAi human phenotypes for ENPEP:
genes like me logo Genes that share phenotypes with ENPEP: view

Animal Models for ENPEP Gene

MGI Knock Outs for ENPEP:

miRNA for ENPEP Gene

miRTarBase miRNAs that target ENPEP

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENPEP

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ENPEP Gene

Localization for ENPEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENPEP Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for ENPEP Gene COMPARTMENTS Subcellular localization image for ENPEP gene
Compartment Confidence
extracellular 5
lysosome 5
plasma membrane 5
vacuole 5
endoplasmic reticulum 2
golgi apparatus 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ENPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 8244382
GO:0005903 brush border ISS --
GO:0009897 external side of plasma membrane ISS --
genes like me logo Genes that share ontologies with ENPEP: view

Pathways & Interactions for ENPEP Gene

genes like me logo Genes that share pathways with ENPEP: view

Pathways by source for ENPEP Gene

Gene Ontology (GO) - Biological Process for ENPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS --
GO:0002003 angiotensin maturation TAS --
GO:0002005 angiotensin catabolic process in blood NAS 19608358
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin NAS 8346219
GO:0006508 proteolysis IBA --
genes like me logo Genes that share ontologies with ENPEP: view

No data available for SIGNOR curated interactions for ENPEP Gene

Drugs & Compounds for ENPEP Gene

(9) Drugs for ENPEP Gene - From: NovoSeek, HMDB, ApexBio, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
Losartan Approved Pharma Antagonist 265
Bestatin Experimental Pharma Inhibition, Inhibitor Aminopeptidase inhibitor 0
L-Glutamic Acid Nutra Full agonist, Agonist, Target 0
Calcium Nutra 0

(7) Additional Compounds for ENPEP Gene - From: NovoSeek

genes like me logo Genes that share compounds with ENPEP: view

Drug Products

Transcripts for ENPEP Gene

Unigene Clusters for ENPEP Gene

Glutamyl aminopeptidase (aminopeptidase A):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENPEP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENPEP Gene

No ASD Table

Relevant External Links for ENPEP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ENPEP Gene

mRNA expression in normal human tissues for ENPEP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENPEP Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x10.5), Kidney - Cortex (x10.2), and Liver (x4.2).

Protein differential expression in normal tissues from HIPED for ENPEP Gene

This gene is overexpressed in Pancreatic juice (24.4) and Urine (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ENPEP Gene

SOURCE GeneReport for Unigene cluster for ENPEP Gene Hs.435765

mRNA Expression by UniProt/SwissProt for ENPEP Gene

Tissue specificity: Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues
genes like me logo Genes that share expression patterns with ENPEP: view

Protein tissue co-expression partners for ENPEP Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for ENPEP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENPEP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ENPEP 35
  • 86.86 (n)
  • 83.74 (a)
  • 83 (a)
(Canis familiaris)
Mammalia ENPEP 35
  • 85.99 (n)
  • 82.91 (a)
  • 83 (a)
(Mus musculus)
Mammalia Enpep 35
  • 80.47 (n)
  • 78.6 (a)
Enpep 16
Enpep 36
  • 78 (a)
(Pan troglodytes)
Mammalia ENPEP 35
  • 99.55 (n)
  • 99.48 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Enpep 35
  • 80.54 (n)
  • 79.24 (a)
(Monodelphis domestica)
Mammalia ENPEP 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
-- 36
  • 72 (a)
(Gallus gallus)
Aves ENPEP 35
  • 69.7 (n)
  • 68.42 (a)
  • 67 (a)
(Anolis carolinensis)
Reptilia ENPEP 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia enpep 35
  • 64.88 (n)
  • 61.51 (a)
(Danio rerio)
Actinopterygii enpep 35
  • 62.29 (n)
  • 60.04 (a)
enpep 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta BG:DS00365.1 37
  • 28 (a)
CG11951 37
  • 35 (a)
CG14516 37
  • 31 (a)
CG2111 37
  • 26 (a)
CG4467 37
  • 24 (a)
CG5849 37
  • 28 (a)
CG6071 37
  • 25 (a)
CG8773 37
  • 37 (a)
CG8774 37
  • 33 (a)
sda 37
  • 30 (a)
CG32473 35
  • 49.56 (n)
  • 41.26 (a)
CG32473 36
  • 35 (a)
CG8773 36
  • 36 (a)
CG8774 36
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003077 35
  • 48.16 (n)
  • 41.65 (a)
(Caenorhabditis elegans)
Secernentea AC3.5 37
  • 23 (a)
R03G8.4 37
  • 26 (a)
R03G8.6 37
  • 28 (a)
T07F10.1 37
  • 29 (a)
T16G12.1 37
  • 28 (a)
Y42A5A.1 37
  • 28 (a)
Y67D8C.9 37
  • 32 (a)
AC3.5 36
  • 19 (a)
R03G8.4 36
  • 24 (a)
T12E12.6 36
  • 22 (a)
T16G12.1 36
  • 12 (a)
Y42A5A.1 36
  • 20 (a)
Y53F4B.20 36
  • 16 (a)
Y67D8C.9 36
  • 19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAP1 36
  • 31 (a)
APE2 36
  • 29 (a)
Species with no ortholog for ENPEP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENPEP Gene

Gene Tree for ENPEP (if available)
Gene Tree for ENPEP (if available)

Paralogs for ENPEP Gene

Paralogs for ENPEP Gene Pseudogenes for ENPEP Gene

genes like me logo Genes that share paralogs with ENPEP: view

Variants for ENPEP Gene

Sequence variations from dbSNP and Humsavar for ENPEP Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_030359 -
VAR_030360 -
VAR_036047 A breast cancer sample
VAR_057056 -
VAR_057057 -

Structural Variations from Database of Genomic Variants (DGV) for ENPEP Gene

Variant ID Type Subtype PubMed ID
nsv830036 CNV Gain 17160897
nsv507187 CNV Insertion 20534489
nsv518506 CNV Loss 19592680

Variation tolerance for ENPEP Gene

Residual Variation Intolerance Score: 57.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENPEP Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENPEP Gene

Disorders for ENPEP Gene

MalaCards: The human disease database

(5) MalaCards diseases for ENPEP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neurogenic hypertension
syphilitic meningitis
  • syphilitic aseptic meningitis
gestational choriocarcinoma
  • gestational chorionepithelioma
human immunodeficiency virus infectious disease
hypertension, essential
  • hypertension, essential 3
- elite association
Search ENPEP in MalaCards View complete list of genes associated with diseases

Relevant External Links for ENPEP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ENPEP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ENPEP Gene

Publications for ENPEP Gene

  1. Comparison of vaginal aminopeptidase enzymatic activities in various animals and in humans. (PMID: 11732752) AcartA1rk F. … SaracoA9lu O.F. (J. Pharm. Pharmacol. 2001) 23 25 26 67
  2. High-resolution genetic map of the human glutamyl aminopeptidase gene (ENPEP). (PMID: 9268642) Li L. … Cooper M.D. (Genomics 1997) 2 23 67
  3. tRNA gene sequences are required for transcriptional silencing in Entamoeba histolytica. (PMID: 20023072) Irmer H. … Tannich E. (Eukaryotic Cell 2010) 23 67
  4. Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide. (PMID: 19187443) Sevalle J. … Checler F. (J. Neurochem. 2009) 23 67
  5. The effect of recombinant aminopeptidase A (APA) on hypertension in pregnant spontaneously hypertensive rats (SHRs). (PMID: 19608358) Ishii M. … Mizutani S. (Early Hum. Dev. 2009) 23 67

Products for ENPEP Gene

Sources for ENPEP Gene

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