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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ENPEP Gene

protein-coding   GIFtS: 64
GCID: GC04P111286

glutamyl aminopeptidase (aminopeptidase A)
 Explore 38 diseases affiliated with
ENPEP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ENPEP    

Aliases
for ENPEP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Glutamyl Aminopeptidase (Aminopeptidase A)1 2     EAP2 3
CD2491 2     EC 3.4.11.73 8
Gp1601     APA2
Aminopeptidase A2 3     Glutamyl Aminopeptidase2
Differentiation Antigen Gp1602 3     CD249 Antigen3
AP-A2 3     EC 3.4.118

External Ids:    HGNC: 33551   Entrez Gene: 20282   Ensembl: ENSG000001387927   OMIM: 1382975   UniProtKB: Q070753   

Export aliases for ENPEP gene to outside databases

Previous GC identifers: GC04P111803 GC04P111679 GC04P111856 GC04P111754 GC04P111397 GC04P107128


Summaries
for ENPEP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: AMPE_HUMAN, Q07075
Function: Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in
regulating growth and differentiation of early B-lineage cells




Genomic Views
for ENPEP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ENPEP gene promoter:
         GR   FOXF2   FOXD3   NF-AT   HNF-1A   NF-AT4   NF-AT2   HNF-1   GR-alpha   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ENPEP promoter sequence
   Search SABiosciences Chromatin IP Primers for ENPEP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENPEP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

ENPEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ENPEP gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P111286:  view genomic region     (about GC identifiers)

Start:
 111,286,889 bp from pter      End:
 111,486,441 bp from pter
Size:
 199,553 bases      Orientation:
 plus strand

Proteins
for ENPEP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AMPE_HUMAN, Q07075 (See protein sequence)
Recommended Name: Glutamyl aminopeptidase  
Size: 957 amino acids; 109244 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homodimer; disulfide-linked
Subcellular location: Membrane; Single-pass type II membrane protein
Secondary accessions: Q504U2

Explore the universe of human proteins at neXtProt for ENPEP: NX_Q07075

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q07075

    • 4/17 DME Specific Peptides for ENPEP (Q07075) (see all 17)
     WLNEGFA  GFYRVNY  GAMENWG  NAKTSDFW 

    ENPEP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001968.3  
    ENSEMBL proteins: 
     ENSP00000265162   ENSP00000426265  
    Reactome Protein details: Q07075
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ENPEP (Aminopeptidase A/ENPEP)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ENPEP
    OriGene Protein Over-expression Lysate: ENPEP
    OriGene Custom Protein Services for ENPEP 
    GenScript Custom Purified and Recombinant Proteins Services for ENPEP
    Novus Biologicals ENPEP Lysate
    Sino Biological Recombinant Protein for ENPEP
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane NAS8244382
    GO:0005903brush border ISS--
    GO:0009897external side of plasma membrane ISS--
    GO:0016324apical plasma membrane ISS--
    GO:0031410cytoplasmic vesicle ISS--


    ENPEP for ontologies           About GeneDecksing



    ENPEP Antibody Products: 
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    Novus Biologicals ENPEP Antibodies
    Abcam antibodies for ENPEP 
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    ThermoFisher Antibodies for ENPEP

    Assay Products for ENPEP: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for ENPEP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ENPEP for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR014782 Peptidase_M1_N
     IPR024571 DUF3358
     IPR001930 Peptidase_M1

    Graphical View of Domain Structure for InterPro Entry Q07075

    ProtoNet protein and cluster: Q07075

    1 Blocks protein family: IPB001930 Membrane alanyl dipeptidase (M1) family signature

    UniProtKB/Swiss-Prot: AMPE_HUMAN, Q07075
    Similarity: Belongs to the peptidase M1 family


    Function
    for ENPEP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AMPE_HUMAN, Q07075
    Function: Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in
    regulating growth and differentiation of early B-lineage cells
    Catalytic activity: Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide

         Genatlas biochemistry entry for ENPEP:
    glutamyl aminopeptidase,homolog of murine B-lymphocyte differentiation antigen BP-1/6C3

    Enzyme Numbers (IUBMB): EC 3.4.11.71 2 EC 3.4.112

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ENPEP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ENPEP
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate ENPEP (see all 50):
    hsa-miR-548j hsa-miR-376b hsa-miR-548k hsa-miR-513a-5p hsa-miR-548l hsa-miR-9 hsa-miR-133a hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmid: ENPEP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ENPEP (see all 7)
    OriGene shRNA RFP: ENPEP
    OriGene siRNA: ENPEP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ENPEP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ENPEP

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ENPEP (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ENPEP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ENPEP (NM_001977)
    Sino Biological Human cDNA Clone for ENPEP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENPEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENPEP 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ENPEP
    Search LifeMap BioReagents cell lines for ENPEP

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENPEP

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IDA8244382
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008233peptidase activity ----
    GO:0008270zinc ion binding IEA--
    GO:0070006metalloaminopeptidase activity NAS8244382


    ENPEP for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Enpeptm1Mdc for ENPEP
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Enpep):
     immune system 

    ENPEP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ENPEP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Renin-angiotensin system
    		Renin-angiotensin system1.00
    		Metabolism of Angiotensinogen to Angiotensins0.48
    2Insulin Processing
    		Peptide hormone metabolism0.39
    3Asparagine N-linked glycosylation
    		Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for ENPEP
        Metabolism of Angiotensinogen to Angiotensins
    Metabolism of proteins
    Peptide hormone metabolism


    1         Kegg Pathway  (Kegg details for ENPEP):
        Renin-angiotensin system


    ENPEP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ENPEP

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ENPEP (Q070753 ENSP000002651624) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGTP010193, ENSP000003556274I2D: score=1 STRING: ENSP00000355627
    CCKP063073, ENSP000003356574I2D: score=1 STRING: ENSP00000335657
    ANPEPENSP000003000604STRING: ENSP00000300060
    ATP6AP2ENSP000003676974STRING: ENSP00000367697
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ISS--
    GO:0002005angiotensin catabolic process in blood NAS19608358
    GO:0003081regulation of systemic arterial blood pressure by renin-angiotensin NAS8346219
    GO:0006508proteolysis IEA--
    GO:0007267cell-cell signaling NAS8346219


    ENPEP for ontologies           About GeneDecksing



    Drugs & Compounds
    for ENPEP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ENPEP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for ENPEP

    Browse Tocris compounds for ENPEP

    2 HMDB Compounds for ENPEP    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    ZincZinc (see all 2)7440-66-6--

    1 DrugBank Compound for ENPEP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--7448199 11732752 17139284 17016423 8568030

    10/14 Novoseek chemical compound relationships for ENPEP gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amastatin 89.8 15 8004400 (2), 10692253 (1), 12612435 (1), 2331601 (1) (see all 11)
    bestatin 65.7 2 2227802 (1)
    ang ii 63.9 11 11994381 (3), 10557335 (2), 15187414 (1), 15507845 (1)
    leucine 47.5 20 12614948 (2), 16769060 (2), 12361682 (2), 12685816 (2) (see all 10)
    losartan 40 3 10985964 (1), 18293706 (1)
    zinc 35.2 11 14674752 (1), 10653662 (1), 8550619 (1), 11724556 (1) (see all 9)
    aspartate 30.2 9 18726831 (1), 1982017 (1), 9681597 (1), 7909847 (1)
    glutamate 22.4 9 12685816 (1), 11724556 (1), 20023072 (1), 1982017 (1) (see all 6)
    sodium 16.9 6 8781481 (2), 8277502 (1), 7920260 (1), 1376904 (1)
    arginine 12.4 4 12685816 (1), 12361682 (1), 11732752 (1)

    Search CenterWatch for drugs/clinical trials and news about ENPEP / AMPE 

    Transcripts
    for ENPEP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ENPEP gene: 
    NM_001977.3  

    Unigene Cluster for ENPEP:

    Glutamyl aminopeptidase (aminopeptidase A)
    Hs.435765  [show with all ESTs]
    Unigene Representative Sequence: NM_001977
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510961 ENST00000265162(uc003iab.4) ENST00000509344 ENST00000502711
    ENST00000504100

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ENPEP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ENPEP
    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate ENPEP (see all 50):
    hsa-miR-548j hsa-miR-376b hsa-miR-548k hsa-miR-513a-5p hsa-miR-548l hsa-miR-9 hsa-miR-133a hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmid: ENPEP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ENPEP (see all 7)
    OriGene shRNA RFP: ENPEP
    OriGene siRNA: ENPEP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ENPEP
    Clone
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    GenScript: all cDNA clones in your preferred vector: ENPEP (NM_001977)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ENPEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ENPEP 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ENPEP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ENPEP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ENPEP

    Additional cDNA sequence: 

    AK313412.1 AM888273.1 AM888274.1 AM888275.1 AM888276.1 AM888277.1 AM888278.1 AM888279.1 
    AM888280.1 AM888281.1 AM888282.1 AM888283.1 BC094770.1 BX641012.1 L12468.1 L14721.1 

    11 DOTS entries:

    DT.212653  DT.92427418  DT.121249716  DT.121249721  DT.75140787  DT.92427419  DT.92427420  DT.102828585 
    DT.75182340  DT.91759774  DT.91759773 

    24/125 AceView cDNA sequences (see all 125):

    AW000915 BG431081 AI640493 AU077305 AU100285 L12468 BX641012 AI307818 
    CF593778 AI935775 AI288822 BG166498 AW451569 BG400415 AL548997 AU139354 
    AL709252 BG413393 AW139905 BG219862 AI670907 AL541184 NM_001977 BU753576 

    GeneLoc Exon Structure


    Expression
    for ENPEP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ENPEP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCTGGAATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ENPEP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyProximal TubuleProximal Tubule CellsKidney
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    HeartCardiac CrescentCardiac Crescent CellsMyocardium
    KidneyPodocyte LayerPodocytesKidney
    Reproductive SystemMesonephrosMesonephric cellsReproductive System
    KidneyMetanephrosKidney
    KidneyRenal VesicleKidney
    KidneyS-shaped BodyKidney
    Reproductive SystemMesonephrosReproductive System
    TestisTestis InterstitiumTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    Adult human kidney epithelial cells (Primary Cell)Kidney
    Parietal epithelial cells (PEC) (Adult Stem / Progenitor Cell)Epithelium, Kidney
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Primitive gut tube-like cells (A scalable, suspensi...)
    Parietal epithelial cells (PEC) (Adult Stem / Progenitor Cell)Epithelium, Kidney

    See ENPEP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ENPEP

    SOURCE GeneReport for Unigene cluster: Hs.435765

    UniProtKB/Swiss-Prot: AMPE_HUMAN, Q07075
    Tissue specificity: Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also
    found in a variety of other tissues

        SABiosciences Custom PCR Arrays for ENPEP
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ENPEP

    Orthologs
    for ENPEP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ENPEP gene from 5/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ENPEP1 glutamyl aminopeptidase (aminopeptidase A) 69.74(n)
    68.49(a)    		   428771  XM_426327.2  XP_426327.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ENPEP6
    		 --
    		 63(a)
    		 1 ↔ 1
    		 5(144020126-144065792)
    zebrafish
    (Danio rerio)    		 Actinopterygii enpep1 glutamyl aminopeptidase 62.29(n)
    60.04(a)    		   504088  NM_001199731.1  NP_001186660.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG87733
    CG324731    		 glutamyl aminopeptidase3
    CG324731    		 37(a)
    (best of 10)3
    49.47(n)1
    40.99(a)1    		   87E43
    416361  NM_169503.21  NP_731786.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y67D8C.93   -- 32(a)
    (best of 7)    		   IV(3077664-3086852)   --


    ENSEMBL Gene Tree for ENPEP (if available)
    TreeFam Gene Tree for ENPEP (if available) 

    Paralogs
    for ENPEP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ENPEP gene
    LNPEP2  ANPEP2  TRHDE2  ERAP12  AQPEP2  NPEPPS2  ENSG000001740932  ERAP22  
    10 SIMAP similar genes for ENPEP using alignment to 14 protein entries:     AMPE_HUMAN (see all proteins):
    TBC1D3    NPEPPSL1    ANPEP    ERAP2    ERAP1    NPEPPS
    TRHDE    LNPEP    AQPEP    FLJ90650

    ENPEP for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ENPEP
    PGOHUM00000242698 PGOHUM00000233313


    Genomic Variants
    for ENPEP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ENPEP
    DNA2.0 Custom Variant and Variant Library Synthesis for ENPEP

    Disorders / Diseases
    for ENPEP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ENPEP for disorders           About GeneDecksing

    OMIM gene information: 138297    OMIM disorders: --

    20/38 diseases for ENPEP (see all 38):    About MalaCards
    cervical intraepithelial neoplasia    focal segmental glomerulosclerosis    human immunodeficiency virus infectious disease    long qt syndrome
    pre-eclampsia    clear cell renal cell carcinoma    non-hodgkin lymphoma    neurogenic hypertension
    glomerulosclerosis    atrial fibrillation    gestational choriocarcinoma    renal cell carcinoma
    hodgkin's lymphoma    alcohol dependence    choriocarcinoma    antiphospholipid syndrome
    glanders    eclampsia    squamous cell carcinoma    cervicitis

    2 diseases from the University of Copenhagen DISEASES database for ENPEP:
    Hypertension     Antiphospholipid syndrome

    10/16 Novoseek disease relationships for ENPEP gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 43.3 12 10692253 (5), 12915695 (3), 11718570 (1)
    systemic hypertension 36.3 1 18206321 (1)
    preeclampsia 34.8 2 15893965 (1), 10985964 (1)
    neoplastic transformation 32.9 5 10838501 (4)
    renal cancer 32.6 2 16985214 (1), 9664120 (1)
    glomerulosclerosis 29.9 4 18206321 (2)
    carcinoma renal cell 24.1 2 9486416 (1), 8346219 (1)
    cervical intraepithelial neoplasia 19.2 2 15048132 (1)
    neovascularization 5.3 2 8869294 (2)
    carcinoma squamous cell 0 2 15048132 (1)

    Human Genome Epidemiology (HuGE) Navigator: ENPEP (3 documents)

    Export disorders for ENPEP gene to outside databases

    Publications
    for ENPEP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ENPEP gene, integrated from 9 sources (see all 147):
    (articles sorted by number of sources associating them with ENPEP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human kidney differentiation antigen gp160: human aminopeptidase A. (PubMed id 8346219)1, 2, 9 Nanus D.M.... Albino A.P. (1993)
    2. cDNA cloning and expression of human glutamyl aminopeptidase (aminopeptidase A). (PubMed id 8244382)1, 2, 9 Li L.... Cooper M.D. (1993)
    3. High-resolution genetic map of the human glutamyl aminopeptidase gene (ENPEP). (PubMed id 9268642)1, 3, 9 Li L....Cooper M.D. (1997)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Regulation of aminopeptidase A expression in cervical carcinoma: role of tumor-stromal interaction and vascular endothelial growth factor. (PubMed id 15048132)1, 9 Suganuma T....Mizutani S. (2004)
    7. Receptor-mediated induction of aminopeptidase A (APA) of human glomerular epithelial cells (HGEC) by glucocorticoids. (PubMed id 1756856)1, 9 Stefanovic V....Ardaillou R. (1991)
    8. Functional genetic variation in aminopeptidase A (ENPEP): lack of clear association with focal and segmental glomerulosclerosis (FSGS). (PubMed id 18206321)1, 9 Tonna S....Pollak M.R. (2008)
    9. The effect of recombinant aminopeptidase A (APA) on h ypertension in pregnant spontaneously hypertensive rats (SHRs). (PubMed id 19608358)1, 9 Ishii M....Mizutani S. (2009)
    10. Aminopeptidase A is a functional target in angiogenic blood vessels. (PubMed id 14998491)1, 9 Marchio S....Arap W. (2004)

    External Searches for ENPEP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ENPEP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2028 HGNC: 3355 AceView: ENPEP Ensembl:ENSG00000138792 euGenes: HUgn2028
    ECgene: ENPEP Kegg: 2028 H-InvDB: ENPEP

    Other Databases showing ENPEP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ENPEP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ENPEP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ENPEP Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ENPEP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ENPEP gene:
    Search GeneIP for patents involving ENPEP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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