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Aliases for ENPEP Gene

Aliases for ENPEP Gene

  • Glutamyl Aminopeptidase (Aminopeptidase A) 2 3
  • Differentiation Antigen Gp160 3 4
  • Aminopeptidase A 3 4
  • EC 3.4.11.7 4 64
  • AP-A 3 4
  • EAP 3 4
  • Glutamyl Aminopeptidase 3
  • CD249 Antigen 4
  • EC 3.4.11 64
  • CD249 3
  • Gp160 3
  • APA 3

External Ids for ENPEP Gene

Summaries for ENPEP Gene

GeneCards Summary for ENPEP Gene

ENPEP (Glutamyl Aminopeptidase (Aminopeptidase A)) is a Protein Coding gene. Diseases associated with ENPEP include neurogenic hypertension and gestational choriocarcinoma. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Peptide hormone metabolism. GO annotations related to this gene include aminopeptidase activity and metalloaminopeptidase activity. An important paralog of this gene is ERAP1.

UniProtKB/Swiss-Prot for ENPEP Gene

  • Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENPEP Gene

Genomics for ENPEP Gene

Genomic Location for ENPEP Gene

Start:
110,365,733 bp from pter
End:
110,565,285 bp from pter
Size:
199,553 bases
Orientation:
Plus strand

Genomic View for ENPEP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ENPEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENPEP Gene

Regulatory Elements for ENPEP Gene

Proteins for ENPEP Gene

  • Protein details for ENPEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07075-AMPE_HUMAN
    Recommended name:
    Glutamyl aminopeptidase
    Protein Accession:
    Q07075
    Secondary Accessions:
    • Q504U2

    Protein attributes for ENPEP Gene

    Size:
    957 amino acids
    Molecular mass:
    109244 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Homodimer; disulfide-linked

    Three dimensional structures from OCA and Proteopedia for ENPEP Gene

neXtProt entry for ENPEP Gene

Proteomics data for ENPEP Gene at MOPED

Post-translational modifications for ENPEP Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn124, Asn197, Asn324, Asn340, Asn554, Asn589, Asn597, Asn607, Asn678, Asn763, Asn773, Asn801, and Asn828

Other Protein References for ENPEP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ENPEP Gene

Gene Families for ENPEP Gene

HGNC:
  • CD :CD molecules
IUPHAR :

Protein Domains for ENPEP Gene

UniProtKB/Swiss-Prot:

AMPE_HUMAN
Family:
  • Belongs to the peptidase M1 family.:
    • Q07075
genes like me logo Genes that share domains with ENPEP: view

Function for ENPEP Gene

Molecular function for ENPEP Gene

GENATLAS Biochemistry: glutamyl aminopeptidase,homolog of murine B-lymphocyte differentiation antigen BP-1/6C3
UniProtKB/Swiss-Prot CatalyticActivity: Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide
UniProtKB/Swiss-Prot Function: Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells

Enzyme Numbers (IUBMB) for ENPEP Gene

Gene Ontology (GO) - Molecular Function for ENPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IDA 8244382
GO:0008233 peptidase activity --
GO:0008237 metallopeptidase activity EXP --
GO:0008270 zinc ion binding IEA --
GO:0070006 metalloaminopeptidase activity NAS 8244382
genes like me logo Genes that share ontologies with ENPEP: view

Phenotypes for ENPEP Gene

MGI mutant phenotypes for ENPEP:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ENPEP: view

Animal Models for ENPEP Gene

MGI Knock Outs for ENPEP:

miRNA for ENPEP Gene

miRTarBase miRNAs that target ENPEP

No data available for Transcription Factor Targeting and HOMER Transcription for ENPEP Gene

Localization for ENPEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENPEP Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ENPEP Gene COMPARTMENTS Subcellular localization image for ENPEP gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ENPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 8244382
GO:0005903 brush border ISS --
GO:0009897 external side of plasma membrane ISS --
genes like me logo Genes that share ontologies with ENPEP: view

Pathways for ENPEP Gene

genes like me logo Genes that share pathways with ENPEP: view

Pathways by source for ENPEP Gene

Gene Ontology (GO) - Biological Process for ENPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS --
GO:0002003 angiotensin maturation TAS --
GO:0002005 angiotensin catabolic process in blood NAS 19608358
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin NAS 8346219
GO:0006508 proteolysis --
genes like me logo Genes that share ontologies with ENPEP: view

Compounds for ENPEP Gene

(2) HMDB Compounds for ENPEP Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Zinc
  • Zinc
7440-66-6

(1) Drugbank Compounds for ENPEP Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target

(14) Novoseek inferred chemical compound relationships for ENPEP Gene

Compound -log(P) Hits PubMed IDs
amastatin 89.8 12
bestatin 65.7 1
ang ii 63.9 7
leucine 47.5 15
losartan 40 2
genes like me logo Genes that share compounds with ENPEP: view

Transcripts for ENPEP Gene

Unigene Clusters for ENPEP Gene

Glutamyl aminopeptidase (aminopeptidase A):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ENPEP Gene

No ASD Table

Relevant External Links for ENPEP Gene

GeneLoc Exon Structure for
ENPEP
ECgene alternative splicing isoforms for
ENPEP

Expression for ENPEP Gene

mRNA expression in normal human tissues for ENPEP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENPEP Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (10.5), Kidney - Cortex (10.2), and Liver (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ENPEP Gene

SOURCE GeneReport for Unigene cluster for ENPEP Gene Hs.435765

mRNA Expression by UniProt/SwissProt for ENPEP Gene

Q07075-AMPE_HUMAN
Tissue specificity: Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues
genes like me logo Genes that share expressions with ENPEP: view

Orthologs for ENPEP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENPEP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ENPEP 36
  • 99.55 (n)
  • 99.48 (a)
ENPEP 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ENPEP 36
  • 86.86 (n)
  • 83.74 (a)
ENPEP 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ENPEP 36
  • 85.99 (n)
  • 82.91 (a)
ENPEP 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Enpep 36
  • 80.47 (n)
  • 78.6 (a)
Enpep 16
Enpep 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ENPEP 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 76 (a)
OneToMany
-- 37
  • 72 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Enpep 36
  • 80.54 (n)
  • 79.24 (a)
chicken
(Gallus gallus)
Aves ENPEP 36
  • 69.7 (n)
  • 68.42 (a)
ENPEP 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ENPEP 37
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia enpep 36
  • 64.88 (n)
  • 61.51 (a)
zebrafish
(Danio rerio)
Actinopterygii enpep 36
  • 62.29 (n)
  • 60.04 (a)
enpep 37
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003077 36
  • 48.16 (n)
  • 41.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32473 36
  • 49.56 (n)
  • 41.26 (a)
CG32473 37
  • 35 (a)
OneToMany
CG8773 37
  • 36 (a)
OneToMany
CG8774 37
  • 36 (a)
OneToMany
BG:DS00365.1 38
  • 28 (a)
CG6071 38
  • 25 (a)
CG11951 38
  • 35 (a)
sda 38
  • 30 (a)
CG5849 38
  • 28 (a)
CG2111 38
  • 26 (a)
CG8774 38
  • 33 (a)
CG14516 38
  • 31 (a)
CG8773 38
  • 37 (a)
CG4467 38
  • 24 (a)
worm
(Caenorhabditis elegans)
Secernentea AC3.5 37
  • 19 (a)
ManyToMany
R03G8.4 37
  • 24 (a)
ManyToMany
T12E12.6 37
  • 22 (a)
ManyToMany
T16G12.1 37
  • 12 (a)
ManyToMany
Y42A5A.1 37
  • 20 (a)
ManyToMany
Y53F4B.20 37
  • 16 (a)
ManyToMany
Y67D8C.9 37
  • 19 (a)
ManyToMany
R03G8.4 38
  • 26 (a)
T07F10.1 38
  • 29 (a)
Y42A5A.1 38
  • 28 (a)
T16G12.1 38
  • 28 (a)
AC3.5 38
  • 23 (a)
R03G8.6 38
  • 28 (a)
Y67D8C.9 38
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAP1 37
  • 31 (a)
ManyToMany
APE2 37
  • 29 (a)
ManyToMany
Species with no ortholog for ENPEP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENPEP Gene

ENSEMBL:
Gene Tree for ENPEP (if available)
TreeFam:
Gene Tree for ENPEP (if available)

Paralogs for ENPEP Gene

Paralogs for ENPEP Gene

Pseudogenes.org Pseudogenes for ENPEP Gene

genes like me logo Genes that share paralogs with ENPEP: view

Variants for ENPEP Gene

Sequence variations from dbSNP and Humsavar for ENPEP Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs17138 -- 110,525,483(-) GGAAC(A/G)GGTGA intron-variant
rs471035 -- 110,525,204(-) CATAC(A/G)AAAAT intron-variant
rs471486 -- 110,534,066(-) GTCCT(C/T)AAACA intron-variant
rs475907 -- 110,533,620(-) CTATC(C/T)TTAGC intron-variant
rs478454 -- 110,542,121(+) TAAAT(C/T)GGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENPEP Gene

Variant ID Type Subtype PubMed ID
nsv830036 CNV Gain 17160897
nsv507187 CNV Insertion 20534489
nsv518506 CNV Loss 19592680

Relevant External Links for ENPEP Gene

HapMap Linkage Disequilibrium report
ENPEP

Disorders for ENPEP Gene

(2) University of Copenhagen DISEASES for ENPEP Gene

(16) Novoseek inferred disease relationships for ENPEP Gene

Disease -log(P) Hits PubMed IDs
choriocarcinoma 43.3 9
systemic hypertension 36.3 1
preeclampsia 34.8 2
neoplastic transformation 32.9 4
renal cancer 32.6 2

Relevant External Links for ENPEP

Genetic Association Database (GAD)
ENPEP
Human Genome Epidemiology (HuGE) Navigator
ENPEP
genes like me logo Genes that share disorders with ENPEP: view

No data available for UniProtKB/Swiss-Prot for ENPEP Gene

Publications for ENPEP Gene

  1. Molecular cloning of the human kidney differentiation antigen gp160: human aminopeptidase A. (PMID: 8346219) Nanus D.M. … Albino A.P. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4 23
  2. High-resolution genetic map of the human glutamyl aminopeptidase gene (ENPEP). (PMID: 9268642) Li L. … Cooper M.D. (Genomics 1997) 2 3 23
  3. cDNA cloning and expression of human glutamyl aminopeptidase (aminopeptidase A). (PMID: 8244382) Li L. … Cooper M.D. (Genomics 1993) 3 4 23
  4. Functional genetic variation in aminopeptidase A (ENPEP): lack of clear association with focal and segmental glomerulosclerosis (FSGS). (PMID: 18206321) Tonna S. … Pollak M.R. (Gene 2008) 3 23 49
  5. Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei. (PMID: 18410507) de Mota N. … Llorens-Cortes C. (J. Neurochem. 2008) 3 23

Products for ENPEP Gene

Sources for ENPEP Gene

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