Aliases for ENOX2 Gene
External Ids for ENOX2 Gene
Previous HGNC Symbols for ENOX2 Gene
Previous GeneCards Identifiers for ENOX2 Gene
This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for ENOX2 Gene
ENOX2 (Ecto-NOX Disulfide-Thiol Exchanger 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and protein disulfide oxidoreductase activity. An important paralog of this gene is ENOX1.
UniProtKB/Swiss-Prot for ENOX2 Gene
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.