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Aliases for ENOX2 Gene

Aliases for ENOX2 Gene

  • Ecto-NOX Disulfide-Thiol Exchanger 2 2 3
  • Cytosolic Ovarian Carcinoma Antigen 1 2 3 4
  • Tumor-Associated Hydroquinone Oxidase 3 4
  • APK1 Antigen 3 4
  • COVA1 3 4
  • TNOX 3 4
  • APK1 3

External Ids for ENOX2 Gene

Previous HGNC Symbols for ENOX2 Gene

  • COVA1

Previous GeneCards Identifiers for ENOX2 Gene

  • GC0XM129586
  • GC0XM129757
  • GC0XM119153

Summaries for ENOX2 Gene

Entrez Gene Summary for ENOX2 Gene

  • This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for ENOX2 Gene

ENOX2 (Ecto-NOX Disulfide-Thiol Exchanger 2) is a Protein Coding gene. Diseases associated with ENOX2 include cervical cancer, somatic. GO annotations related to this gene include nucleic acid binding and protein disulfide oxidoreductase activity. An important paralog of this gene is ENOX1.

UniProtKB/Swiss-Prot for ENOX2 Gene

  • May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.

Gene Wiki entry for ENOX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENOX2 Gene

Genomics for ENOX2 Gene

Regulatory Elements for ENOX2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ENOX2 Gene

Chromosome:
X
Start:
130,623,369 bp from pter
End:
130,903,317 bp from pter
Size:
279,949 bases
Orientation:
Minus strand

Genomic View for ENOX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ENOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENOX2 Gene

Proteins for ENOX2 Gene

  • Protein details for ENOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16206-ENOX2_HUMAN
    Recommended name:
    Ecto-NOX disulfide-thiol exchanger 2
    Protein Accession:
    Q16206
    Secondary Accessions:
    • A8K197
    • A8K1C2
    • Q5VTJ1
    • Q5VTJ2
    • Q8WUX0
    • Q9NTP6
    • Q9UH82

    Protein attributes for ENOX2 Gene

    Size:
    610 amino acids
    Molecular mass:
    70082 Da
    Cofactor:
    Name=Cu cation; Xref=ChEBI:CHEBI:23378;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Has several properties associated with prions including resistance to proteases, resistance to cyanogen bromide digestion, and the ability to form amyloid filaments resembling those of spongiform encephalopathies
    SequenceCaution:
    • Sequence=AAB30428.1; Type=Frameshift; Positions=302, 357; Evidence={ECO:0000305};

    Alternative splice isoforms for ENOX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENOX2 Gene

Proteomics data for ENOX2 Gene at MOPED

Post-translational modifications for ENOX2 Gene

Other Protein References for ENOX2 Gene

No data available for DME Specific Peptides for ENOX2 Gene

Domains & Families for ENOX2 Gene

Gene Families for ENOX2 Gene

Protein Domains for ENOX2 Gene

Suggested Antigen Peptide Sequences for ENOX2 Gene

Graphical View of Domain Structure for InterPro Entry

Q16206

UniProtKB/Swiss-Prot:

ENOX2_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the ENOX family.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the ENOX family.
genes like me logo Genes that share domains with ENOX2: view

Function for ENOX2 Gene

Molecular function for ENOX2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the antitumor sulfonylurea LY181984, the vabilloid capsaicin, and retinoids.
UniProtKB/Swiss-Prot Function:
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.

Gene Ontology (GO) - Molecular Function for ENOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0015035 protein disulfide oxidoreductase activity IDA 1888291
genes like me logo Genes that share ontologies with ENOX2: view

Phenotypes for ENOX2 Gene

genes like me logo Genes that share phenotypes with ENOX2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENOX2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ENOX2 Gene

Localization for ENOX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENOX2 Gene

Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ENOX2 Gene COMPARTMENTS Subcellular localization image for ENOX2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for ENOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005829 cytosol TAS 8150545
GO:0009897 external side of plasma membrane IDA 11488599
genes like me logo Genes that share ontologies with ENOX2: view

Pathways & Interactions for ENOX2 Gene

SuperPathways for ENOX2 Gene

No Data Available

SIGNOR curated interactions for ENOX2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ENOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007624 ultradian rhythm IDA 12356293
GO:0016049 cell growth NAS 9932650
GO:0040008 regulation of growth IEA --
GO:0055114 oxidation-reduction process IDA 11888291
genes like me logo Genes that share ontologies with ENOX2: view

No data available for Pathways by source for ENOX2 Gene

Drugs & Compounds for ENOX2 Gene

(8) Drugs for ENOX2 Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenoxodiol Investigational Pharma Target Caspase activator, XIAP inhibitor, FLIP suppressor, and TOPO II inhibitor 0
Copper Pharma 143
NAD Pharma Agonist, Activator 0
Capsaicin Pharma Activator 138
Hydroquinone Pharma 33

(6) Additional Compounds for ENOX2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2,4-dichlorophenoxyacetic acid
  • (2, 4-Dichlorophenoxy)acetic acid
  • (2,4-Dichloor-fenoxy)-azijnzuur
  • (2,4-Dichloor-fenoxy)-azijnzuur (DUTCH)
  • (2,4-Dichlor-phenoxy)-essigsaeure
  • (2,4-Dichlor-phenoxy)-essigsaeure (GERMAN)
94-75-7
EGCG
989-51-5
nad+
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Quinone
  • 1,4-Benzoquine
  • 1,4-Benzoquinone
  • 1,4-Cyclohexadiene dioxide
  • 1,4-Cyclohexadienedione
  • 1,4-Diossibenzene
106-51-4
genes like me logo Genes that share compounds with ENOX2: view

Transcripts for ENOX2 Gene

Unigene Clusters for ENOX2 Gene

Ecto-NOX disulfide-thiol exchanger 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENOX2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENOX2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for ENOX2 Gene

GeneLoc Exon Structure for
ENOX2
ECgene alternative splicing isoforms for
ENOX2

Expression for ENOX2 Gene

mRNA expression in normal human tissues for ENOX2 Gene

Protein differential expression in normal tissues from HIPED for ENOX2 Gene

This gene is overexpressed in Plasma (48.8) and Stomach (20.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ENOX2 Gene



SOURCE GeneReport for Unigene cluster for ENOX2 Gene Hs.171458

mRNA Expression by UniProt/SwissProt for ENOX2 Gene

Q16206-ENOX2_HUMAN
Tissue specificity: Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells
genes like me logo Genes that share expression patterns with ENOX2: view

Protein tissue co-expression partners for ENOX2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ENOX2 Gene

Orthologs for ENOX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ENOX2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ENOX2 35
  • 92.92 (n)
  • 97.98 (a)
ENOX2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Enox2 35
  • 90.36 (n)
  • 94.49 (a)
Enox2 16
Enox2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ENOX2 35
  • 97.03 (n)
  • 96.05 (a)
ENOX2 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Enox2 35
  • 90.76 (n)
  • 94.79 (a)
oppossum
(Monodelphis domestica)
Mammalia ENOX2 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ENOX2 35
  • 78.43 (n)
  • 87.44 (a)
ENOX2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ENOX2 36
  • 83 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii enox2 35
  • 70.93 (n)
  • 76.32 (a)
AL929322.1 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10948 36
  • 27 (a)
OneToMany
Species with no ortholog for ENOX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ENOX2 Gene

ENSEMBL:
Gene Tree for ENOX2 (if available)
TreeFam:
Gene Tree for ENOX2 (if available)

Paralogs for ENOX2 Gene

Paralogs for ENOX2 Gene

(1) SIMAP similar genes for ENOX2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ENOX2: view

Variants for ENOX2 Gene

Sequence variations from dbSNP and Humsavar for ENOX2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs10496 -- 130,624,134(-) GAGGA(A/T)GGAGG utr-variant-3-prime
rs739000 -- 130,735,707(-) tattc(A/C)taatt intron-variant
rs761417 -- 130,851,030(+) CTTTG(C/T)CTGTT intron-variant
rs1535062 -- 130,874,976(+) ACTCA(C/G)GAATA intron-variant
rs1546932 -- 130,659,694(+) CAAAA(A/C)TGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENOX2 Gene

Variant ID Type Subtype PubMed ID
esv2740477 CNV Deletion 23290073
nsv527144 CNV Gain 19592680
esv28068 CNV Gain 19812545
esv2669990 CNV Deletion 23128226
esv2740478 CNV Deletion 23290073

Variation tolerance for ENOX2 Gene

Residual Variation Intolerance Score: 11.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 26.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENOX2 Gene

HapMap Linkage Disequilibrium report
ENOX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENOX2 Gene

Disorders for ENOX2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ENOX2 Gene - From: DISEASES and NovoSeek

Disorder Aliases PubMed IDs
cervical cancer, somatic
  • cervical cancer
- elite association
Search ENOX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ENOX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ENOX2
genes like me logo Genes that share disorders with ENOX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ENOX2 Gene

Publications for ENOX2 Gene

  1. ECTO-NOX target for the anticancer isoflavene phenoxodiol. (PMID: 17518268) MorrAc D.J. … MorrAc D.M. (Oncol. Res. 2007) 23 25 67
  2. Molecular cloning and characterization of a tumor-associated, growth- related, and time-keeping hydroquinone (NADH) oxidase (tNOX) of the HeLa cell surface. (PMID: 11888291) Chueh P.-J. … Morre D.J. (Biochemistry 2002) 2 23 67
  3. Early developmental expression of a normally tumor-associated and drug-inhibited cell surface-located NADH oxidase (ENOX2) in non-cancer cells. (PMID: 18704408) Cho N. … MorrAc D.J. (Cancer Immunol. Immunother. 2009) 23 67
  4. Supplementation with CoQ10 lowers age-related (ar) NOX levels in healthy subjects. (PMID: 19096119) MorrAc D.M. … Kern D. (Biofactors 2008) 23 67
  5. Cancer type-specific tNOX isoforms: A putative family of redox protein splice variants with cancer diagnostic and prognostic potential. (PMID: 19734121) MorrAc D.J. … MorrAc D.M. (Biofactors 2008) 23 67

Products for ENOX2 Gene

Sources for ENOX2 Gene

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