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Aliases for ENOX1 Gene

Aliases for ENOX1 Gene

  • Ecto-NOX Disulfide-Thiol Exchanger 1 2 3 5
  • Candidate Growth-Related And Time Keeping Constitutive Hydroquinone [NADH] Oxidase 3 4
  • Cell Proliferation-Inducing Gene 38 Protein 3 4
  • Constitutive Ecto-NOX 3 4
  • CCNOX 3 4
  • CNOX 3 4
  • Candidate Growth-Related And Time Keeping Constitutive Hydroquinone (NADH) Oxidase 3
  • BA64J21.1 3
  • PIG38 3

External Ids for ENOX1 Gene

Previous GeneCards Identifiers for ENOX1 Gene

  • GC13M042687
  • GC13M043787
  • GC13M024589

Summaries for ENOX1 Gene

Entrez Gene Summary for ENOX1 Gene

  • Electron transport pathways are generally associated with mitochondrial membranes, but non-mitochondrial pathways are also biologically significant. Plasma membrane electron transport pathways are involved in functions as diverse as cellular defense, intracellular redox homeostasis, and control of cell growth and survival. Members of the ecto-NOX family, such as CNOX, or ENOX1, are involved in plasma membrane transport pathways. These enzymes exhibit both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity in series, with each activity cycling every 22 to 26 minutes (Scarlett et al., 2005 [PubMed 15882838]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ENOX1 Gene

ENOX1 (Ecto-NOX Disulfide-Thiol Exchanger 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and oxidoreductase activity. An important paralog of this gene is ENOX2.

UniProtKB/Swiss-Prot for ENOX1 Gene

  • Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENOX1 Gene

Genomics for ENOX1 Gene

Regulatory Elements for ENOX1 Gene

Promoters for ENOX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ENOX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ENOX1 Gene

Chromosome:
13
Start:
43,213,130 bp from pter
End:
43,786,980 bp from pter
Size:
573,851 bases
Orientation:
Minus strand

Genomic View for ENOX1 Gene

Genes around ENOX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENOX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENOX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENOX1 Gene

Proteins for ENOX1 Gene

  • Protein details for ENOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC92-ENOX1_HUMAN
    Recommended name:
    Ecto-NOX disulfide-thiol exchanger 1
    Protein Accession:
    Q8TC92
    Secondary Accessions:
    • A4GU15
    • A6NMH9
    • B7Z5K1
    • Q2TU81
    • Q5VT11
    • Q9NWE0

    Protein attributes for ENOX1 Gene

    Size:
    643 amino acids
    Molecular mass:
    73348 Da
    Cofactor:
    Name=Cu cation; Xref=ChEBI:CHEBI:23378;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ENOX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENOX1 Gene

Proteomics data for ENOX1 Gene at MOPED

Post-translational modifications for ENOX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ENOX1 Gene

No data available for DME Specific Peptides for ENOX1 Gene

Domains & Families for ENOX1 Gene

Gene Families for ENOX1 Gene

Protein Domains for ENOX1 Gene

Suggested Antigen Peptide Sequences for ENOX1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TC92

UniProtKB/Swiss-Prot:

ENOX1_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the ENOX family.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the ENOX family.
genes like me logo Genes that share domains with ENOX1: view

Function for ENOX1 Gene

Molecular function for ENOX1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Not inhibited by the antitumor sulfonylurea LY181984, the vabilloid capsaicin, and retinoids.
UniProtKB/Swiss-Prot Function:
Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.

Gene Ontology (GO) - Molecular Function for ENOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with ENOX1: view
genes like me logo Genes that share phenotypes with ENOX1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ENOX1

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENOX1 Gene

Localization for ENOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENOX1 Gene

Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ENOX1 Gene COMPARTMENTS Subcellular localization image for ENOX1 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytosol 2
nucleus 2
cytoskeleton 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ENOX1 Gene

Pathways & Interactions for ENOX1 Gene

SuperPathways for ENOX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ENOX1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ENOX1 Gene

Drugs & Compounds for ENOX1 Gene

(2) Drugs for ENOX1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Pharma 158
NAD Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with ENOX1: view

Transcripts for ENOX1 Gene

mRNA/cDNA for ENOX1 Gene

(13) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ENOX1 Gene

Ecto-NOX disulfide-thiol exchanger 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ENOX1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7:
SP8:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ENOX1 Gene

GeneLoc Exon Structure for
ENOX1
ECgene alternative splicing isoforms for
ENOX1

Expression for ENOX1 Gene

mRNA expression in normal human tissues for ENOX1 Gene

Protein differential expression in normal tissues from HIPED for ENOX1 Gene

This gene is overexpressed in Stomach (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ENOX1 Gene



SOURCE GeneReport for Unigene cluster for ENOX1 Gene Hs.128258

mRNA Expression by UniProt/SwissProt for ENOX1 Gene

Q8TC92-ENOX1_HUMAN
Tissue specificity: Expressed in lymphocyte cells, breast and breast cancer (at protein level). Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Found also in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells.
genes like me logo Genes that share expression patterns with ENOX1: view

Protein tissue co-expression partners for ENOX1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ENOX1 Gene

Orthologs for ENOX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ENOX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ENOX1 36
  • 100 (a)
OneToOne
ENOX1 35
  • 99.9 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia ENOX1 35
  • 89.63 (n)
  • 98.13 (a)
ENOX1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ENOX1 36
  • 90 (a)
OneToOne
ENOX1 35
  • 92.68 (n)
  • 97.98 (a)
mouse
(Mus musculus)
Mammalia Enox1 16
Enox1 36
  • 98 (a)
OneToOne
Enox1 35
  • 89.74 (n)
  • 97.67 (a)
oppossum
(Monodelphis domestica)
Mammalia ENOX1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ENOX1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Enox1 35
  • 89.32 (n)
  • 97.98 (a)
chicken
(Gallus gallus)
Aves ENOX1 35
  • 85.18 (n)
  • 93.26 (a)
ENOX1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ENOX1 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia enox1 35
  • 77.34 (n)
  • 83.81 (a)
Str.674 35
zebrafish
(Danio rerio)
Actinopterygii enox1 35
  • 70.85 (n)
  • 72.76 (a)
enox1 36
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011541 35
  • 50.39 (n)
  • 42.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10948 35
  • 51.85 (n)
  • 45.56 (a)
CG10948 36
  • 27 (a)
OneToMany
Species with no ortholog for ENOX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ENOX1 Gene

ENSEMBL:
Gene Tree for ENOX1 (if available)
TreeFam:
Gene Tree for ENOX1 (if available)

Paralogs for ENOX1 Gene

Paralogs for ENOX1 Gene

(1) SIMAP similar genes for ENOX1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ENOX1: view

Variants for ENOX1 Gene

Sequence variations from dbSNP and Humsavar for ENOX1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs7338624 - 43,412,867(+) GGAAG(C/G)TCCTG intron-variant, reference, missense
rs393632 -- 43,700,594(-) Aagtt(C/T)cctgg intron-variant
rs394223 -- 43,678,007(-) CTCAC(C/T)AATTC intron-variant
rs396274 -- 43,718,383(-) tccct(C/T)tccca intron-variant
rs406731 -- 43,698,262(+) CCTTT(A/G)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENOX1 Gene

Variant ID Type Subtype PubMed ID
esv33538 CNV Gain 17666407
dgv1575n71 CNV Gain 21882294
esv2751145 CNV Gain 17911159
nsv832594 CNV Gain+Loss 17160897
nsv516197 CNV Gain 19592680
esv2751146 CNV Gain 17911159
dgv1577n71 CNV Gain 21882294
nsv518904 CNV Gain 19592680
esv2667272 CNV Deletion 23128226
nsv526810 CNV Loss 19592680
esv26544 CNV Loss 19812545
esv2662839 CNV Deletion 23128226
nsv900029 CNV Loss 21882294
nsv516714 CNV Loss 19592680
nsv1019 CNV Insertion 18451855
esv2747324 CNV Deletion 23290073
nsv900030 CNV Loss 21882294
esv271752 CNV Insertion 20981092
nsv528539 CNV Loss 19592680
nsv826632 CNV Loss 20364138
esv275158 CNV Loss 21479260
nsv832595 CNV Gain 17160897
esv2747325 CNV Deletion 23290073

Variation tolerance for ENOX1 Gene

Residual Variation Intolerance Score: 8.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.99; 60.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENOX1 Gene

HapMap Linkage Disequilibrium report
ENOX1
Human Gene Mutation Database (HGMD)
ENOX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENOX1 Gene

Disorders for ENOX1 Gene

Relevant External Links for ENOX1

Genetic Association Database (GAD)
ENOX1
Human Genome Epidemiology (HuGE) Navigator
ENOX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ENOX1

No disorders were found for ENOX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENOX1 Gene

Publications for ENOX1 Gene

  1. A drug-unresponsive and protease-resistant CNOX protein from human sera. (PMID: 11360993) Sedlak D. … Moore D.J. (Arch. Biochem. Biophys. 2001) 2 3 4 67
  2. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. (PMID: 23377640) (Am J Psychiatry 2013) 3
  5. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PMID: 22491018) Wang J. … Platt A. (Pharmacogenomics J. 2013) 3

Products for ENOX1 Gene

Sources for ENOX1 Gene

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