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Aliases for ENOSF1 Gene

Aliases for ENOSF1 Gene

  • Enolase Superfamily Member 1 2 3
  • Antisense RNA To Thymidylate Synthase 3 4
  • L-Fuconate Dehydratase 3 4
  • TYMSAS 3 4
  • RTS 3 4
  • EC 4.2.1.68 4
  • HSRTSBETA 3

External Ids for ENOSF1 Gene

Summaries for ENOSF1 Gene

Entrez Gene Summary for ENOSF1 Gene

  • This gene was originally identified as a naturally occurring antisense transcript to the human thymidylate synthase gene. Alternate splice variants have been described, one of which (named rTSalpha) represents an alternate 3'UTR that is complementary to the 3'UTR and terminal intron of the thymidylate synthase (TS) RNA and down-regulates TS expression. Other transcript variants (rTSbeta and rTSgamma) do not overlap the TS locus. The function of this gene appears to be primarily to regulate expression of the TS locus both via the antisense transcript as well as through the encoded proteins. [provided by RefSeq, Mar 2010]

GeneCards Summary for ENOSF1 Gene

ENOSF1 (Enolase Superfamily Member 1) is a Protein Coding gene. Among its related pathways are Fructose and mannose metabolism. GO annotations related to this gene include magnesium ion binding and L-fuconate dehydratase activity.

UniProtKB/Swiss-Prot for ENOSF1 Gene

  • Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion (PubMed:24697329).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENOSF1 Gene

Genomics for ENOSF1 Gene

Regulatory Elements for ENOSF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ENOSF1 Gene

Chromosome:
18
Start:
670,324 bp from pter
End:
712,676 bp from pter
Size:
42,353 bases
Orientation:
Minus strand

Genomic View for ENOSF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ENOSF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENOSF1 Gene

Proteins for ENOSF1 Gene

  • Protein details for ENOSF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L5Y1-ENOF1_HUMAN
    Recommended name:
    Mitochondrial enolase superfamily member 1
    Protein Accession:
    Q7L5Y1
    Secondary Accessions:
    • A6NMP3
    • A8K9R5
    • B3KSL6
    • B3KXE4
    • D3DUH0
    • Q15407
    • Q15594
    • Q15595
    • Q6ZS08
    • Q9HAS5
    • Q9HAS6

    Protein attributes for ENOSF1 Gene

    Size:
    443 amino acids
    Molecular mass:
    49786 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG29537.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA47471.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ENOSF1 Gene

    Alternative splice isoforms for ENOSF1 Gene

neXtProt entry for ENOSF1 Gene

Proteomics data for ENOSF1 Gene at MOPED

Post-translational modifications for ENOSF1 Gene

Antibody Products

No data available for DME Specific Peptides for ENOSF1 Gene

Domains & Families for ENOSF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q7L5Y1

UniProtKB/Swiss-Prot:

ENOF1_HUMAN :
  • Belongs to the mandelate racemase/muconate lactonizing enzyme family. ENOSF1 subfamily.
Family:
  • Belongs to the mandelate racemase/muconate lactonizing enzyme family. ENOSF1 subfamily.
genes like me logo Genes that share domains with ENOSF1: view

No data available for Gene Families for ENOSF1 Gene

Function for ENOSF1 Gene

Molecular function for ENOSF1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.2 mM for L-fuconate {ECO:0000269 PubMed:24697329}; KM=3.0 mM for L-galactonate {ECO:0000269 PubMed:24697329}; KM=2.0 mM for D-arabinonate {ECO:0000269 PubMed:24697329}; KM=4.0 mM for L-arabinonate {ECO:0000269 PubMed:24697329}; KM=0.4 mM for D-ribonate {ECO:0000269 PubMed:24697329}; Note=kcat is 0.5 sec(-1) for L-fuconate. kcat is 0.3 sec(-1) for L-galactonate. kcat is 0.3 sec(-1) for L-arabinonate. kcat is 0.04 sec(-1) for D-arabinonate. kcat is 0.002 sec(-1) for D- ribonate.;
UniProtKB/Swiss-Prot CatalyticActivity:
L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H(2)O.
UniProtKB/Swiss-Prot Function:
Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion (PubMed:24697329).

Enzyme Numbers (IUBMB) for ENOSF1 Gene

Gene Ontology (GO) - Molecular Function for ENOSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 24697329
GO:0003824 catalytic activity --
GO:0016853 isomerase activity IEA --
GO:0050023 L-fuconate dehydratase activity IDA 24697329
genes like me logo Genes that share ontologies with ENOSF1: view

Phenotypes for ENOSF1 Gene

GenomeRNAi human phenotypes for ENOSF1:
genes like me logo Genes that share phenotypes with ENOSF1: view

Animal Model Products

CRISPR Products

miRNA for ENOSF1 Gene

miRTarBase miRNAs that target ENOSF1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENOSF1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ENOSF1 Gene

Localization for ENOSF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENOSF1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ENOSF1 Gene COMPARTMENTS Subcellular localization image for ENOSF1 gene
Compartment Confidence
mitochondrion 3

Gene Ontology (GO) - Cellular Components for ENOSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ENOSF1: view

Pathways & Interactions for ENOSF1 Gene

genes like me logo Genes that share pathways with ENOSF1: view

Pathways by source for ENOSF1 Gene

1 KEGG pathway for ENOSF1 Gene

Interacting Proteins for ENOSF1 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000345974%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000365534%0d%0a9606.ENSP00000286621%0d%0a9606.ENSP00000306817%0d%0a
Selected Interacting proteins: ENSP00000345974 for ENOSF1 Gene via STRING

Gene Ontology (GO) - Biological Process for ENOSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0009063 cellular amino acid catabolic process IEA --
GO:0044275 cellular carbohydrate catabolic process IDA 24697329
genes like me logo Genes that share ontologies with ENOSF1: view

No data available for SIGNOR curated interactions for ENOSF1 Gene

Drugs & Compounds for ENOSF1 Gene

(4) Drugs for ENOSF1 Gene - From: HMDB and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Capecitabine Approved, Investigational Pharma RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1179
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1387
Paclitaxel Approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 2505
Magnesium Nutra 0
genes like me logo Genes that share compounds with ENOSF1: view

Transcripts for ENOSF1 Gene

Unigene Clusters for ENOSF1 Gene

Enolase superfamily member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ENOSF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENOSF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d ^
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7: - - - - - - - - -
SP8: -
SP9:
SP10:
SP11: - - -
SP12:
SP13: -
SP14: - -

ExUns: 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17
SP1: -
SP2: - -
SP3: - - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ENOSF1 Gene

GeneLoc Exon Structure for
ENOSF1
ECgene alternative splicing isoforms for
ENOSF1

Expression for ENOSF1 Gene

mRNA expression in normal human tissues for ENOSF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ENOSF1 Gene

This gene is overexpressed in Gallbladder (16.8) and Liver (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ENOSF1 Gene



SOURCE GeneReport for Unigene cluster for ENOSF1 Gene Hs.731510

genes like me logo Genes that share expression patterns with ENOSF1: view

Protein tissue co-expression partners for ENOSF1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ENOSF1 Gene

Orthologs for ENOSF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENOSF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ENOSF1 35
  • 86.31 (n)
  • 88.71 (a)
ENOSF1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ENOSF1 35
  • 88.41 (n)
  • 91.2 (a)
ENOSF1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ENOSF1 35
  • 99.25 (n)
  • 99.1 (a)
ENOSF1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ENOSF1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ENOSF1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ENOSF1 36
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.22084 35
enosf1 35
  • 68.41 (n)
  • 73.02 (a)
enosf1 36
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007421 35
  • 55.3 (n)
  • 56.56 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1598 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07064 35
  • 57.6 (n)
  • 52.96 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToOne
Species with no ortholog for ENOSF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ENOSF1 Gene

ENSEMBL:
Gene Tree for ENOSF1 (if available)
TreeFam:
Gene Tree for ENOSF1 (if available)

Paralogs for ENOSF1 Gene

No data available for Paralogs for ENOSF1 Gene

Variants for ENOSF1 Gene

Sequence variations from dbSNP and Humsavar for ENOSF1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs8423 -- 674,012(-) CTGTA(A/C)TTTGA intron-variant, utr-variant-3-prime, nc-transcript-variant
rs495139 -- 676,008(+) AGGAA(C/G)CAAAC intron-variant
rs499305 -- 679,374(+) tggct(A/T)atttt intron-variant
rs500224 -- 679,469(+) ctccc(A/C)aagtg intron-variant
rs519208 -- 701,717(-) tacag(G/T)ggcgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ENOSF1 Gene

Variant ID Type Subtype PubMed ID
nsv909287 CNV Gain 21882294
nsv909288 CNV Loss 21882294
nsv909289 CNV Loss 21882294
nsv833577 CNV Gain+Loss 17160897
nsv528169 CNV Loss 19592680
dgv1006e1 CNV Complex 17122850
esv2664396 CNV Deletion 23128226
nsv527894 CNV Loss 19592680
nsv523729 CNV Loss 19592680
esv2716656 CNV Deletion 23290073
nsv131646 CNV Loss 16902084
esv1238079 CNV Insertion 17803354

Variation tolerance for ENOSF1 Gene

Residual Variation Intolerance Score: 63.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.35; 76.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ENOSF1 Gene

HapMap Linkage Disequilibrium report
ENOSF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENOSF1 Gene

Disorders for ENOSF1 Gene

Relevant External Links for ENOSF1

Genetic Association Database (GAD)
ENOSF1
Human Genome Epidemiology (HuGE) Navigator
ENOSF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ENOSF1
genes like me logo Genes that share disorders with ENOSF1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENOSF1 Gene

Publications for ENOSF1 Gene

  1. Association of thymidylate synthase gene with endometrial cancer risk in a Chinese population. (PMID: 19190136) Xu W.H. … Shu X.O. (Cancer Epidemiol. Biomarkers Prev. 2009) 23 67
  2. Evolution of enzymatic activities in the enolase superfamily: L-fuconate dehydratase from Xanthomonas campestris. (PMID: 17144652) Yew W.S. … Gerlt J.A. (Biochemistry 2006) 23 67
  3. Comparative genomic analysis reveals a novel mitochondrial isoform of human rTS protein and unusual phylogenetic distribution of the rTS gene. (PMID: 16162288) Liang P. … Dolnick B.J. (BMC Genomics 2005) 23 67
  4. A novel function for the rTS gene. (PMID: 14508106) Dolnick B.J. … Sufrin J.R. (Cancer Biol. Ther. 2003) 2 67
  5. [Study of differential expressed genes in vascular endothelial cell line ECV304 induced by low density lipoprotein]. (PMID: 11372378) Zhang K. … Wu G. (Zhonghua Yi Xue Za Zhi 2000) 23 67

Products for ENOSF1 Gene

Sources for ENOSF1 Gene

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